RF008


 16 16  0  0  0  0  0  0  0  0999 V2000
   43.9552  -70.0927   83.4156 C   0  0  0  0  0  0  0  0  0  0  0  0
   43.0174  -69.5699   82.6553 N   0  0  0  0  0  0  0  0  0  0  0  0
   41.7534  -69.7506   83.1872 N   0  0  0  0  0  0  0  0  0  0  0  0
   41.8062  -70.4237   84.3176 C   0  0  0  0  0  0  0  0  0  0  0  0
   43.3762  -70.8572   84.8251 S   0  0  0  0  0  0  0  0  0  0  0  0
   40.4465  -70.8716   85.3492 S   0  0  0  0  0  0  0  0  0  0  0  0
   40.3292  -72.3088   85.2487 O   0  0  0  0  0  0  0  0  0  0  0  0
   39.3646  -69.9736   85.0158 O   0  0  0  0  0  0  0  0  0  0  0  0
   40.8537  -70.5307   86.9503 N   0  0  0  0  0  0  0  0  0  0  0  0
   41.6362  -71.0820   87.2978 H   0  0  0  0  0  0  0  0  0  0  0  0
   40.8721  -69.5322   87.1493 H   0  0  0  0  0  0  0  0  0  0  0  0
   47.3594  -70.3126   81.9077 C   0  0  0  0  0  0  0  0  0  0  0  0
   45.8803  -70.6019   81.9787 C   0  0  0  0  0  0  0  0  0  0  0  0
   45.3426  -71.3065   81.1320 O   0  0  0  0  0  0  0  0  0  0  0  0
   45.2841  -70.0301   83.0781 N   0  0  0  0  0  0  0  0  0  0  0  0
   45.8493  -69.5375   83.7569 H   0  0  0  0  0  0  0  0  0  0  0  0
 12 13  1  0  0  0
 13 14  2  0  0  0
 13 15  1  0  0  0
 15  1  1  0  0  0
  1  2  2  0  0  0
  2  3  1  0  0  0
  3  4  2  0  0  0
  4  5  1  0  0  0
  4  6  1  0  0  0
  6  7  2  0  0  0
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  6  9  1  0  0  0
  5  1  1  0  0  0
 15 16  1  0  0  0
  9 10  1  0  0  0
  9 11  1  0  0  0
M  END
> <minimizedAffinity>
-6.61211

$$$$
RF008


 16 16  0  0  0  0  0  0  0  0999 V2000
   44.6774  -67.9368   86.3992 C   0  0  0  0  0  0  0  0  0  0  0  0
   44.1248  -67.0923   85.5552 N   0  0  0  0  0  0  0  0  0  0  0  0
   43.2100  -67.7107   84.7221 N   0  0  0  0  0  0  0  0  0  0  0  0
   43.1382  -69.0015   84.9714 C   0  0  0  0  0  0  0  0  0  0  0  0
   44.1428  -69.5476   86.2375 S   0  0  0  0  0  0  0  0  0  0  0  0
   42.0990  -70.1801   84.1685 S   0  0  0  0  0  0  0  0  0  0  0  0
   42.5954  -71.4794   84.5620 O   0  0  0  0  0  0  0  0  0  0  0  0
   41.9994  -69.7665   82.7875 O   0  0  0  0  0  0  0  0  0  0  0  0
   40.5429  -70.0441   84.8054 N   0  0  0  0  0  0  0  0  0  0  0  0
   40.4858  -70.2786   85.7948 H   0  0  0  0  0  0  0  0  0  0  0  0
   40.0668  -69.1946   84.5073 H   0  0  0  0  0  0  0  0  0  0  0  0
   46.6745  -66.9171   89.3795 C   0  0  0  0  0  0  0  0  0  0  0  0
   45.4136  -67.3323   88.6624 C   0  0  0  0  0  0  0  0  0  0  0  0
   44.3530  -67.4225   89.2703 O   0  0  0  0  0  0  0  0  0  0  0  0
   45.6158  -67.5377   87.3179 N   0  0  0  0  0  0  0  0  0  0  0  0
   46.5227  -67.3493   86.9116 H   0  0  0  0  0  0  0  0  0  0  0  0
 12 13  1  0  0  0
 13 14  2  0  0  0
 13 15  1  0  0  0
 15  1  1  0  0  0
  1  2  2  0  0  0
  2  3  1  0  0  0
  3  4  2  0  0  0
  4  5  1  0  0  0
  4  6  1  0  0  0
  6  7  2  0  0  0
  6  8  2  0  0  0
  6  9  1  0  0  0
  5  1  1  0  0  0
 15 16  1  0  0  0
  9 10  1  0  0  0
  9 11  1  0  0  0
M  END
> <minimizedAffinity>
-5.79106

$$$$
RF008


 16 16  0  0  0  0  0  0  0  0999 V2000
   41.8839  -70.5937   84.1141 C   0  0  0  0  0  0  0  0  0  0  0  0
   41.9954  -69.7602   83.1022 N   0  0  0  0  0  0  0  0  0  0  0  0
   43.3055  -69.6246   82.6798 N   0  0  0  0  0  0  0  0  0  0  0  0
   44.1190  -70.3527   83.4158 C   0  0  0  0  0  0  0  0  0  0  0  0
   43.3598  -71.2647   84.6414 S   0  0  0  0  0  0  0  0  0  0  0  0
   45.8677  -70.5012   83.2324 S   0  0  0  0  0  0  0  0  0  0  0  0
   46.4327  -69.3231   83.8509 O   0  0  0  0  0  0  0  0  0  0  0  0
   46.1078  -70.8503   81.8509 O   0  0  0  0  0  0  0  0  0  0  0  0
   46.3915  -71.8223   84.1411 N   0  0  0  0  0  0  0  0  0  0  0  0
   46.2436  -71.7122   85.1427 H   0  0  0  0  0  0  0  0  0  0  0  0
   46.1202  -72.7150   83.7330 H   0  0  0  0  0  0  0  0  0  0  0  0
   38.5177  -71.8378   85.1296 C   0  0  0  0  0  0  0  0  0  0  0  0
   39.7254  -71.7588   84.2286 C   0  0  0  0  0  0  0  0  0  0  0  0
   39.7732  -72.4129   83.1931 O   0  0  0  0  0  0  0  0  0  0  0  0
   40.6722  -70.8765   84.6934 N   0  0  0  0  0  0  0  0  0  0  0  0
   40.4836  -70.3270   85.5214 H   0  0  0  0  0  0  0  0  0  0  0  0
 12 13  1  0  0  0
 13 14  2  0  0  0
 13 15  1  0  0  0
 15  1  1  0  0  0
  1  2  2  0  0  0
  2  3  1  0  0  0
  3  4  2  0  0  0
  4  5  1  0  0  0
  4  6  1  0  0  0
  6  7  2  0  0  0
  6  8  2  0  0  0
  6  9  1  0  0  0
  5  1  1  0  0  0
 15 16  1  0  0  0
  9 10  1  0  0  0
  9 11  1  0  0  0
M  END
> <minimizedAffinity>
-5.32601

$$$$
RF008


 16 16  0  0  0  0  0  0  0  0999 V2000
   44.8704  -68.7066   85.3351 C   0  0  0  0  0  0  0  0  0  0  0  0
   43.7767  -68.0686   84.9777 N   0  0  0  0  0  0  0  0  0  0  0  0
   43.0654  -67.6012   86.0681 N   0  0  0  0  0  0  0  0  0  0  0  0
   43.6554  -67.9335   87.1973 C   0  0  0  0  0  0  0  0  0  0  0  0
   45.1126  -68.8029   87.0199 S   0  0  0  0  0  0  0  0  0  0  0  0
   43.1168  -67.5396   88.8307 S   0  0  0  0  0  0  0  0  0  0  0  0
   43.2077  -68.7690   89.5855 O   0  0  0  0  0  0  0  0  0  0  0  0
   41.8845  -66.7982   88.6894 O   0  0  0  0  0  0  0  0  0  0  0  0
   44.2248  -66.4685   89.5166 N   0  0  0  0  0  0  0  0  0  0  0  0
   45.1543  -66.8664   89.6383 H   0  0  0  0  0  0  0  0  0  0  0  0
   44.1750  -65.5354   89.1116 H   0  0  0  0  0  0  0  0  0  0  0  0
   46.6454  -70.6707   82.7080 C   0  0  0  0  0  0  0  0  0  0  0  0
   45.4910  -70.3591   83.6282 C   0  0  0  0  0  0  0  0  0  0  0  0
   44.4972  -71.0764   83.6446 O   0  0  0  0  0  0  0  0  0  0  0  0
   45.7267  -69.2551   84.4133 N   0  0  0  0  0  0  0  0  0  0  0  0
   46.6242  -68.7907   84.3709 H   0  0  0  0  0  0  0  0  0  0  0  0
 12 13  1  0  0  0
 13 14  2  0  0  0
 13 15  1  0  0  0
 15  1  1  0  0  0
  1  2  2  0  0  0
  2  3  1  0  0  0
  3  4  2  0  0  0
  4  5  1  0  0  0
  4  6  1  0  0  0
  6  7  2  0  0  0
  6  8  2  0  0  0
  6  9  1  0  0  0
  5  1  1  0  0  0
 15 16  1  0  0  0
  9 10  1  0  0  0
  9 11  1  0  0  0
M  END
> <minimizedAffinity>
-5.20126

$$$$
RF008


 16 16  0  0  0  0  0  0  0  0999 V2000
   45.2205  -70.4169   87.2698 C   0  0  0  0  0  0  0  0  0  0  0  0
   45.8719  -71.5420   87.0675 N   0  0  0  0  0  0  0  0  0  0  0  0
   46.0505  -71.8068   85.7217 N   0  0  0  0  0  0  0  0  0  0  0  0
   45.5012  -70.8703   84.9769 C   0  0  0  0  0  0  0  0  0  0  0  0
   44.7608  -69.6017   85.8447 S   0  0  0  0  0  0  0  0  0  0  0  0
   45.4947  -70.7854   83.2144 S   0  0  0  0  0  0  0  0  0  0  0  0
   45.0280  -72.0748   82.7571 O   0  0  0  0  0  0  0  0  0  0  0  0
   46.7719  -70.2331   82.8250 O   0  0  0  0  0  0  0  0  0  0  0  0
   44.3371  -69.6553   82.7367 N   0  0  0  0  0  0  0  0  0  0  0  0
   43.3852  -69.9161   82.9879 H   0  0  0  0  0  0  0  0  0  0  0  0
   44.6166  -68.6960   82.9334 H   0  0  0  0  0  0  0  0  0  0  0  0
   44.8276  -68.5852   90.4948 C   0  0  0  0  0  0  0  0  0  0  0  0
   45.3521  -68.7776   89.0932 C   0  0  0  0  0  0  0  0  0  0  0  0
   46.0956  -67.9448   88.5872 O   0  0  0  0  0  0  0  0  0  0  0  0
   44.9318  -69.9603   88.5315 N   0  0  0  0  0  0  0  0  0  0  0  0
   44.3856  -70.6111   89.0802 H   0  0  0  0  0  0  0  0  0  0  0  0
 12 13  1  0  0  0
 13 14  2  0  0  0
 13 15  1  0  0  0
 15  1  1  0  0  0
  1  2  2  0  0  0
  2  3  1  0  0  0
  3  4  2  0  0  0
  4  5  1  0  0  0
  4  6  1  0  0  0
  6  7  2  0  0  0
  6  8  2  0  0  0
  6  9  1  0  0  0
  5  1  1  0  0  0
 15 16  1  0  0  0
  9 10  1  0  0  0
  9 11  1  0  0  0
M  END
> <minimizedAffinity>
-5.19565

$$$$
RF008


 16 16  0  0  0  0  0  0  0  0999 V2000
   40.3216  -80.3008   86.5050 C   0  0  0  0  0  0  0  0  0  0  0  0
   41.1041  -81.1553   85.8817 N   0  0  0  0  0  0  0  0  0  0  0  0
   41.1561  -80.9179   84.5200 N   0  0  0  0  0  0  0  0  0  0  0  0
   40.3873  -79.9026   84.1858 C   0  0  0  0  0  0  0  0  0  0  0  0
   39.5766  -79.1540   85.4869 S   0  0  0  0  0  0  0  0  0  0  0  0
   40.1551  -79.2362   82.5685 S   0  0  0  0  0  0  0  0  0  0  0  0
   39.1216  -78.2338   82.6974 O   0  0  0  0  0  0  0  0  0  0  0  0
   40.0432  -80.3636   81.6717 O   0  0  0  0  0  0  0  0  0  0  0  0
   41.5626  -78.4236   82.1167 N   0  0  0  0  0  0  0  0  0  0  0  0
   41.7734  -77.6175   82.7022 H   0  0  0  0  0  0  0  0  0  0  0  0
   42.3345  -79.0551   81.9107 H   0  0  0  0  0  0  0  0  0  0  0  0
   40.3493  -79.9721   90.2200 C   0  0  0  0  0  0  0  0  0  0  0  0
   40.8623  -79.7083   88.8258 C   0  0  0  0  0  0  0  0  0  0  0  0
   41.8561  -79.0128   88.6495 O   0  0  0  0  0  0  0  0  0  0  0  0
   40.1228  -80.3527   87.8620 N   0  0  0  0  0  0  0  0  0  0  0  0
   39.3708  -80.9712   88.1356 H   0  0  0  0  0  0  0  0  0  0  0  0
 12 13  1  0  0  0
 13 14  2  0  0  0
 13 15  1  0  0  0
 15  1  1  0  0  0
  1  2  2  0  0  0
  2  3  1  0  0  0
  3  4  2  0  0  0
  4  5  1  0  0  0
  4  6  1  0  0  0
  6  7  2  0  0  0
  6  8  2  0  0  0
  6  9  1  0  0  0
  5  1  1  0  0  0
 15 16  1  0  0  0
  9 10  1  0  0  0
  9 11  1  0  0  0
M  END
> <minimizedAffinity>
-5.14298

$$$$
RF008


 16 16  0  0  0  0  0  0  0  0999 V2000
   45.2290  -70.8321   84.9870 C   0  0  0  0  0  0  0  0  0  0  0  0
   45.3534  -71.8297   85.8356 N   0  0  0  0  0  0  0  0  0  0  0  0
   44.3566  -71.8263   86.7946 N   0  0  0  0  0  0  0  0  0  0  0  0
   43.5412  -70.8060   86.6277 C   0  0  0  0  0  0  0  0  0  0  0  0
   43.9041  -69.8044   85.2952 S   0  0  0  0  0  0  0  0  0  0  0  0
   42.1236  -70.4116   87.6016 S   0  0  0  0  0  0  0  0  0  0  0  0
   42.2631  -69.0178   87.9586 O   0  0  0  0  0  0  0  0  0  0  0  0
   41.9961  -71.4619   88.5858 O   0  0  0  0  0  0  0  0  0  0  0  0
   40.7536  -70.5252   86.6240 N   0  0  0  0  0  0  0  0  0  0  0  0
   40.7405  -69.8508   85.8610 H   0  0  0  0  0  0  0  0  0  0  0  0
   40.5137  -71.4869   86.3901 H   0  0  0  0  0  0  0  0  0  0  0  0
   47.0678  -70.5468   81.7547 C   0  0  0  0  0  0  0  0  0  0  0  0
   45.8809  -70.8910   82.6203 C   0  0  0  0  0  0  0  0  0  0  0  0
   44.8669  -71.3689   82.1246 O   0  0  0  0  0  0  0  0  0  0  0  0
   46.1114  -70.6425   83.9530 N   0  0  0  0  0  0  0  0  0  0  0  0
   47.0232  -70.3249   84.2545 H   0  0  0  0  0  0  0  0  0  0  0  0
 12 13  1  0  0  0
 13 14  2  0  0  0
 13 15  1  0  0  0
 15  1  1  0  0  0
  1  2  2  0  0  0
  2  3  1  0  0  0
  3  4  2  0  0  0
  4  5  1  0  0  0
  4  6  1  0  0  0
  6  7  2  0  0  0
  6  8  2  0  0  0
  6  9  1  0  0  0
  5  1  1  0  0  0
 15 16  1  0  0  0
  9 10  1  0  0  0
  9 11  1  0  0  0
M  END
> <minimizedAffinity>
-5.05240

$$$$
RF008


 16 16  0  0  0  0  0  0  0  0999 V2000
   45.2906  -70.3262   87.2866 C   0  0  0  0  0  0  0  0  0  0  0  0
   45.8204  -71.5154   87.0968 N   0  0  0  0  0  0  0  0  0  0  0  0
   45.9312  -71.8290   85.7542 N   0  0  0  0  0  0  0  0  0  0  0  0
   45.4555  -70.8603   84.9999 C   0  0  0  0  0  0  0  0  0  0  0  0
   44.8715  -69.5035   85.8534 S   0  0  0  0  0  0  0  0  0  0  0  0
   45.4043  -70.8175   83.2366 S   0  0  0  0  0  0  0  0  0  0  0  0
   44.6825  -69.6141   82.8900 O   0  0  0  0  0  0  0  0  0  0  0  0
   44.9858  -72.1318   82.8057 O   0  0  0  0  0  0  0  0  0  0  0  0
   46.9771  -70.6207   82.6596 N   0  0  0  0  0  0  0  0  0  0  0  0
   47.4020  -69.7352   82.9288 H   0  0  0  0  0  0  0  0  0  0  0  0
   47.5476  -71.4566   82.7742 H   0  0  0  0  0  0  0  0  0  0  0  0
   44.3373  -69.5417   90.8060 C   0  0  0  0  0  0  0  0  0  0  0  0
   44.3207  -70.3656   89.5421 C   0  0  0  0  0  0  0  0  0  0  0  0
   43.6471  -71.3874   89.4742 O   0  0  0  0  0  0  0  0  0  0  0  0
   45.0869  -69.8128   88.5430 N   0  0  0  0  0  0  0  0  0  0  0  0
   45.5325  -68.9166   88.6891 H   0  0  0  0  0  0  0  0  0  0  0  0
 12 13  1  0  0  0
 13 14  2  0  0  0
 13 15  1  0  0  0
 15  1  1  0  0  0
  1  2  2  0  0  0
  2  3  1  0  0  0
  3  4  2  0  0  0
  4  5  1  0  0  0
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  6  7  2  0  0  0
  6  8  2  0  0  0
  6  9  1  0  0  0
  5  1  1  0  0  0
 15 16  1  0  0  0
  9 10  1  0  0  0
  9 11  1  0  0  0
M  END
> <minimizedAffinity>
-5.05226

$$$$
RF008


 16 16  0  0  0  0  0  0  0  0999 V2000
   41.8816  -72.1348   84.4310 C   0  0  0  0  0  0  0  0  0  0  0  0
   41.3298  -71.2322   83.6488 N   0  0  0  0  0  0  0  0  0  0  0  0
   41.8631  -69.9718   83.8494 N   0  0  0  0  0  0  0  0  0  0  0  0
   42.7800  -69.9895   84.7942 C   0  0  0  0  0  0  0  0  0  0  0  0
   43.0776  -71.5228   85.4805 S   0  0  0  0  0  0  0  0  0  0  0  0
   43.7327  -68.6215   85.3727 S   0  0  0  0  0  0  0  0  0  0  0  0
   45.0444  -68.7750   84.7849 O   0  0  0  0  0  0  0  0  0  0  0  0
   43.5193  -68.5465   86.7999 O   0  0  0  0  0  0  0  0  0  0  0  0
   43.0790  -67.2044   84.7322 N   0  0  0  0  0  0  0  0  0  0  0  0
   43.1378  -67.1512   83.7169 H   0  0  0  0  0  0  0  0  0  0  0  0
   42.1858  -66.9557   85.1535 H   0  0  0  0  0  0  0  0  0  0  0  0
   41.5436  -75.8362   84.1222 C   0  0  0  0  0  0  0  0  0  0  0  0
   42.2754  -74.5216   84.0095 C   0  0  0  0  0  0  0  0  0  0  0  0
   43.4212  -74.4823   83.5759 O   0  0  0  0  0  0  0  0  0  0  0  0
   41.5024  -73.4535   84.4001 N   0  0  0  0  0  0  0  0  0  0  0  0
   40.5364  -73.6012   84.6612 H   0  0  0  0  0  0  0  0  0  0  0  0
 12 13  1  0  0  0
 13 14  2  0  0  0
 13 15  1  0  0  0
 15  1  1  0  0  0
  1  2  2  0  0  0
  2  3  1  0  0  0
  3  4  2  0  0  0
  4  5  1  0  0  0
  4  6  1  0  0  0
  6  7  2  0  0  0
  6  8  2  0  0  0
  6  9  1  0  0  0
  5  1  1  0  0  0
 15 16  1  0  0  0
  9 10  1  0  0  0
  9 11  1  0  0  0
M  END
> <minimizedAffinity>
-4.96073

$$$$
