{"page_meta":{"limit":10,"next":null,"offset":0,"previous":null,"total_count":1},"targets":[{"cross_references":[],"organism":"Homo sapiens","pref_name":"Receptor tyrosine-protein kinase erbB-2","species_group_flag":false,"target_chembl_id":"CHEMBL1824","target_components":[{"accession":"P04626","component_description":"Receptor tyrosine-protein kinase erbB-2","component_id":120,"component_type":"PROTEIN","relationship":"SINGLE PROTEIN","target_component_synonyms":[{"component_synonym":"2.7.10.1","syn_type":"EC_NUMBER"},{"component_synonym":"CD_antigen=CD340","syn_type":"UNIPROT"},{"component_synonym":"ERBB2","syn_type":"GENE_SYMBOL"},{"component_synonym":"HER2","syn_type":"GENE_SYMBOL_OTHER"},{"component_synonym":"Metastatic lymph node gene 19 protein","syn_type":"UNIPROT"},{"component_synonym":"MLN 19","syn_type":"UNIPROT"},{"component_synonym":"MLN19","syn_type":"GENE_SYMBOL_OTHER"},{"component_synonym":"NEU","syn_type":"GENE_SYMBOL_OTHER"},{"component_synonym":"NGL","syn_type":"GENE_SYMBOL_OTHER"},{"component_synonym":"p185erbB2","syn_type":"UNIPROT"},{"component_synonym":"Proto-oncogene c-ErbB-2","syn_type":"UNIPROT"},{"component_synonym":"Proto-oncogene Neu","syn_type":"UNIPROT"},{"component_synonym":"Receptor tyrosine-protein kinase erbB-2","syn_type":"UNIPROT"},{"component_synonym":"Tyrosine kinase-type cell surface receptor HER2","syn_type":"UNIPROT"}],"target_component_xrefs":[{"xref_id":"P04626","xref_name":null,"xref_src_db":"AlphaFoldDB"},{"xref_id":"P04626","xref_name":null,"xref_src_db":"ExpressionAtlas"},{"xref_id":"GO:0002116","xref_name":"semaphorin receptor complex","xref_src_db":"GoComponent"},{"xref_id":"GO:0005634","xref_name":"nucleus","xref_src_db":"GoComponent"},{"xref_id":"GO:0005654","xref_name":"nucleoplasm","xref_src_db":"GoComponent"},{"xref_id":"GO:0005737","xref_name":"cytoplasm","xref_src_db":"GoComponent"},{"xref_id":"GO:0005768","xref_name":"endosome","xref_src_db":"GoComponent"},{"xref_id":"GO:0005769","xref_name":"early endosome","xref_src_db":"GoComponent"},{"xref_id":"GO:0005829","xref_name":"cytosol","xref_src_db":"GoComponent"},{"xref_id":"GO:0005886","xref_name":"plasma membrane","xref_src_db":"GoComponent"},{"xref_id":"GO:0009925","xref_name":"basal plasma membrane","xref_src_db":"GoComponent"},{"xref_id":"GO:0010008","xref_name":"endosome membrane","xref_src_db":"GoComponent"},{"xref_id":"GO:0016020","xref_name":"membrane","xref_src_db":"GoComponent"},{"xref_id":"GO:0016323","xref_name":"basolateral plasma membrane","xref_src_db":"GoComponent"},{"xref_id":"GO:0016324","xref_name":"apical plasma membrane","xref_src_db":"GoComponent"},{"xref_id":"GO:0031594","xref_name":"neuromuscular junction","xref_src_db":"GoComponent"},{"xref_id":"GO:0032587","xref_name":"ruffle membrane","xref_src_db":"GoComponent"},{"xref_id":"GO:0038143","xref_name":"ERBB3:ERBB2 complex","xref_src_db":"GoComponent"},{"xref_id":"GO:0042734","xref_name":"presynaptic membrane","xref_src_db":"GoComponent"},{"xref_id":"GO:0042995","xref_name":"cell projection","xref_src_db":"GoComponent"},{"xref_id":"GO:0043209","xref_name":"myelin sheath","xref_src_db":"GoComponent"},{"xref_id":"GO:0043235","xref_name":"receptor complex","xref_src_db":"GoComponent"},{"xref_id":"GO:0048471","xref_name":"perinuclear region of cytoplasm","xref_src_db":"GoComponent"},{"xref_id":"GO:0001042","xref_name":"RNA polymerase I core binding","xref_src_db":"GoFunction"},{"xref_id":"GO:0004714","xref_name":"transmembrane receptor protein tyrosine kinase activity","xref_src_db":"GoFunction"},{"xref_id":"GO:0004888","xref_name":"transmembrane signaling receptor activity","xref_src_db":"GoFunction"},{"xref_id":"GO:0005004","xref_name":"GPI-linked ephrin receptor activity","xref_src_db":"GoFunction"},{"xref_id":"GO:0005005","xref_name":"transmembrane-ephrin receptor activity","xref_src_db":"GoFunction"},{"xref_id":"GO:0005006","xref_name":"epidermal growth factor receptor activity","xref_src_db":"GoFunction"},{"xref_id":"GO:0005007","xref_name":"fibroblast growth factor receptor activity","xref_src_db":"GoFunction"},{"xref_id":"GO:0005008","xref_name":"hepatocyte growth factor receptor activity","xref_src_db":"GoFunction"},{"xref_id":"GO:0005009","xref_name":"insulin receptor activity","xref_src_db":"GoFunction"},{"xref_id":"GO:0005010","xref_name":"insulin-like growth factor receptor activity","xref_src_db":"GoFunction"},{"xref_id":"GO:0005011","xref_name":"macrophage colony-stimulating factor receptor activity","xref_src_db":"GoFunction"},{"xref_id":"GO:0005018","xref_name":"platelet-derived growth factor alpha-receptor activity","xref_src_db":"GoFunction"},{"xref_id":"GO:0005019","xref_name":"platelet-derived growth factor beta-receptor activity","xref_src_db":"GoFunction"},{"xref_id":"GO:0005020","xref_name":"stem cell factor receptor activity","xref_src_db":"GoFunction"},{"xref_id":"GO:0005021","xref_name":"vascular endothelial growth factor receptor activity","xref_src_db":"GoFunction"},{"xref_id":"GO:0005102","xref_name":"signaling receptor binding","xref_src_db":"GoFunction"},{"xref_id":"GO:0005515","xref_name":"protein binding","xref_src_db":"GoFunction"},{"xref_id":"GO:0005524","xref_name":"ATP binding","xref_src_db":"GoFunction"},{"xref_id":"GO:0008288","xref_name":"boss receptor activity","xref_src_db":"GoFunction"},{"xref_id":"GO:0015026","xref_name":"coreceptor activity","xref_src_db":"GoFunction"},{"xref_id":"GO:0019838","xref_name":"growth factor binding","xref_src_db":"GoFunction"},{"xref_id":"GO:0030971","xref_name":"receptor tyrosine kinase binding","xref_src_db":"GoFunction"},{"xref_id":"GO:0036332","xref_name":"placental growth factor receptor activity","xref_src_db":"GoFunction"},{"xref_id":"GO:0038062","xref_name":"protein tyrosine kinase collagen receptor activity","xref_src_db":"GoFunction"},{"xref_id":"GO:0042802","xref_name":"identical protein binding","xref_src_db":"GoFunction"},{"xref_id":"GO:0043125","xref_name":"ErbB-3 class receptor binding","xref_src_db":"GoFunction"},{"xref_id":"GO:0046982","xref_name":"protein heterodimerization activity","xref_src_db":"GoFunction"},{"xref_id":"GO:0060175","xref_name":"brain-derived neurotrophic factor receptor activity","xref_src_db":"GoFunction"},{"xref_id":"GO:0001934","xref_name":"positive regulation of protein phosphorylation","xref_src_db":"GoProcess"},{"xref_id":"GO:0006468","xref_name":"protein phosphorylation","xref_src_db":"GoProcess"},{"xref_id":"GO:0007165","xref_name":"signal transduction","xref_src_db":"GoProcess"},{"xref_id":"GO:0007166","xref_name":"cell surface receptor signaling pathway","xref_src_db":"GoProcess"},{"xref_id":"GO:0007167","xref_name":"enzyme-linked receptor protein signaling pathway","xref_src_db":"GoProcess"},{"xref_id":"GO:0007169","xref_name":"cell surface receptor protein tyrosine kinase signaling pathway","xref_src_db":"GoProcess"},{"xref_id":"GO:0007399","xref_name":"nervous system development","xref_src_db":"GoProcess"},{"xref_id":"GO:0007422","xref_name":"peripheral nervous system development","xref_src_db":"GoProcess"},{"xref_id":"GO:0007507","xref_name":"heart development","xref_src_db":"GoProcess"},{"xref_id":"GO:0007528","xref_name":"neuromuscular junction development","xref_src_db":"GoProcess"},{"xref_id":"GO:0008283","xref_name":"cell population proliferation","xref_src_db":"GoProcess"},{"xref_id":"GO:0008284","xref_name":"positive regulation of cell population proliferation","xref_src_db":"GoProcess"},{"xref_id":"GO:0008286","xref_name":"insulin receptor signaling pathway","xref_src_db":"GoProcess"},{"xref_id":"GO:0008543","xref_name":"fibroblast growth factor receptor signaling pathway","xref_src_db":"GoProcess"},{"xref_id":"GO:0010628","xref_name":"positive regulation of gene expression","xref_src_db":"GoProcess"},{"xref_id":"GO:0010646","xref_name":"regulation of cell communication","xref_src_db":"GoProcess"},{"xref_id":"GO:0014044","xref_name":"Schwann cell development","xref_src_db":"GoProcess"},{"xref_id":"GO:0018108","xref_name":"peptidyl-tyrosine phosphorylation","xref_src_db":"GoProcess"},{"xref_id":"GO:0022008","xref_name":"neurogenesis","xref_src_db":"GoProcess"},{"xref_id":"GO:0023051","xref_name":"regulation of signaling","xref_src_db":"GoProcess"},{"xref_id":"GO:0030182","xref_name":"neuron differentiation","xref_src_db":"GoProcess"},{"xref_id":"GO:0030307","xref_name":"positive regulation of cell growth","xref_src_db":"GoProcess"},{"xref_id":"GO:0031547","xref_name":"brain-derived neurotrophic factor receptor signaling pathway","xref_src_db":"GoProcess"},{"xref_id":"GO:0032886","xref_name":"regulation of microtubule-based process","xref_src_db":"GoProcess"},{"xref_id":"GO:0033080","xref_name":"immature T cell proliferation in thymus","xref_src_db":"GoProcess"},{"xref_id":"GO:0033088","xref_name":"negative regulation of immature T cell proliferation in thymus","xref_src_db":"GoProcess"},{"xref_id":"GO:0035025","xref_name":"positive regulation of Rho protein signal transduction","xref_src_db":"GoProcess"},{"xref_id":"GO:0035556","xref_name":"intracellular signal transduction","xref_src_db":"GoProcess"},{"xref_id":"GO:0035790","xref_name":"platelet-derived growth factor receptor-alpha signaling pathway","xref_src_db":"GoProcess"},{"xref_id":"GO:0035791","xref_name":"platelet-derived growth factor receptor-beta signaling pathway","xref_src_db":"GoProcess"},{"xref_id":"GO:0036323","xref_name":"vascular endothelial growth factor receptor-1 signaling pathway","xref_src_db":"GoProcess"},{"xref_id":"GO:0038063","xref_name":"collagen-activated tyrosine kinase receptor signaling pathway","xref_src_db":"GoProcess"},{"xref_id":"GO:0038084","xref_name":"vascular endothelial growth factor signaling pathway","xref_src_db":"GoProcess"},{"xref_id":"GO:0038109","xref_name":"Kit signaling pathway","xref_src_db":"GoProcess"},{"xref_id":"GO:0038127","xref_name":"ERBB signaling pathway","xref_src_db":"GoProcess"},{"xref_id":"GO:0038133","xref_name":"ERBB2-ERBB3 signaling pathway","xref_src_db":"GoProcess"},{"xref_id":"GO:0038134","xref_name":"ERBB2-EGFR signaling pathway","xref_src_db":"GoProcess"},{"xref_id":"GO:0038135","xref_name":"ERBB2-ERBB4 signaling pathway","xref_src_db":"GoProcess"},{"xref_id":"GO:0038145","xref_name":"macrophage colony-stimulating factor signaling pathway","xref_src_db":"GoProcess"},{"xref_id":"GO:0042127","xref_name":"regulation of cell population proliferation","xref_src_db":"GoProcess"},{"xref_id":"GO:0042552","xref_name":"myelination","xref_src_db":"GoProcess"},{"xref_id":"GO:0043066","xref_name":"negative regulation of apoptotic process","xref_src_db":"GoProcess"},{"xref_id":"GO:0043406","xref_name":"positive regulation of MAP kinase activity","xref_src_db":"GoProcess"},{"xref_id":"GO:0043410","xref_name":"positive regulation of MAPK cascade","xref_src_db":"GoProcess"},{"xref_id":"GO:0043491","xref_name":"phosphatidylinositol 3-kinase/protein kinase B signal transduction","xref_src_db":"GoProcess"},{"xref_id":"GO:0045727","xref_name":"positive regulation of translation","xref_src_db":"GoProcess"},{"xref_id":"GO:0045765","xref_name":"regulation of angiogenesis","xref_src_db":"GoProcess"},{"xref_id":"GO:0045785","xref_name":"positive regulation of cell adhesion","xref_src_db":"GoProcess"},{"xref_id":"GO:0045943","xref_name":"positive regulation of transcription by RNA polymerase I","xref_src_db":"GoProcess"},{"xref_id":"GO:0048009","xref_name":"insulin-like growth factor receptor signaling pathway","xref_src_db":"GoProcess"},{"xref_id":"GO:0048012","xref_name":"hepatocyte growth factor receptor signaling pathway","xref_src_db":"GoProcess"},{"xref_id":"GO:0048013","xref_name":"ephrin receptor signaling pathway","xref_src_db":"GoProcess"},{"xref_id":"GO:0048709","xref_name":"oligodendrocyte differentiation","xref_src_db":"GoProcess"},{"xref_id":"GO:0050679","xref_name":"positive regulation of epithelial cell proliferation","xref_src_db":"GoProcess"},{"xref_id":"GO:0070372","xref_name":"regulation of ERK1 and ERK2 cascade","xref_src_db":"GoProcess"},{"xref_id":"GO:0071526","xref_name":"semaphorin-plexin signaling pathway","xref_src_db":"GoProcess"},{"xref_id":"GO:0090314","xref_name":"positive regulation of protein targeting to membrane","xref_src_db":"GoProcess"},{"xref_id":"GO:0099645","xref_name":"neurotransmitter receptor localization to postsynaptic specialization membrane","xref_src_db":"GoProcess"},{"xref_id":"HGNC:3430","xref_name":"ERBB2","xref_src_db":"HGNC"},{"xref_id":"P04626","xref_name":null,"xref_src_db":"IntAct"},{"xref_id":"IPR000494","xref_name":"Rcpt_L-dom","xref_src_db":"InterPro"},{"xref_id":"IPR000719","xref_name":"Prot_kinase_dom","xref_src_db":"InterPro"},{"xref_id":"IPR001245","xref_name":"Ser-Thr/Tyr_kinase_cat_dom","xref_src_db":"InterPro"},{"xref_id":"IPR006211","xref_name":"Furin-like_Cys-rich_dom","xref_src_db":"InterPro"},{"xref_id":"IPR006212","xref_name":"Furin_repeat","xref_src_db":"InterPro"},{"xref_id":"IPR008266","xref_name":"Tyr_kinase_AS","xref_src_db":"InterPro"},{"xref_id":"IPR009030","xref_name":"Growth_fac_rcpt_cys_sf","xref_src_db":"InterPro"},{"xref_id":"IPR011009","xref_name":"Kinase-like_dom_sf","xref_src_db":"InterPro"},{"xref_id":"IPR016245","xref_name":"Tyr_kinase_EGF/ERB/XmrK_rcpt","xref_src_db":"InterPro"},{"xref_id":"IPR017441","xref_name":"Protein_kinase_ATP_BS","xref_src_db":"InterPro"},{"xref_id":"IPR020635","xref_name":"Tyr_kinase_cat_dom","xref_src_db":"InterPro"},{"xref_id":"IPR032778","xref_name":"GF_recep_IV","xref_src_db":"InterPro"},{"xref_id":"IPR036941","xref_name":"Rcpt_L-dom_sf","xref_src_db":"InterPro"},{"xref_id":"IPR049328","xref_name":"TM_ErbB1","xref_src_db":"InterPro"},{"xref_id":"IPR050122","xref_name":"RTK","xref_src_db":"InterPro"},{"xref_id":"PTHR24416","xref_name":"TYROSINE-PROTEIN KINASE RECEPTOR","xref_src_db":"PANTHER"},{"xref_id":"PTHR24416:SF137","xref_name":"RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2","xref_src_db":"PANTHER"},{"xref_id":"1MFG","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"1MFL","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"1MW4","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"1N8Z","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"1QR1","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"1S78","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"2A91","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"2JWA","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"2KS1","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"2L4K","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"2N2A","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"3BE1","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"3H3B","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"3MZW","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"3N85","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"3PP0","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"3RCD","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"3WLW","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"3WSQ","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"4GFU","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"4HRL","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"4HRM","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"4HRN","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"4NND","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"5K33","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"5KWG","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"5MY6","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"5O4G","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"5OB4","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"5TQS","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"6ATT","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"6BGT","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"6J71","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"6LBX","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"6OGE","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"7JXH","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"7MN5","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"7MN6","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"7MN8","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"7PCD","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"7QVK","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"8FFJ","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"8HGO","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"8HGP","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"8JYQ","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"8JYR","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"8PWH","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"8Q6J","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"8U4K","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"8U4L","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"8U8X","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"8VB5","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"8VQD","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"8VQE","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"9IUT","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"9L1S","xref_name":null,"xref_src_db":"PDB"},{"xref_id":"1MFG","xref_name":"A","xref_src_db":"PDBe"},{"xref_id":"1MFL","xref_name":"A","xref_src_db":"PDBe"},{"xref_id":"1N8Z","xref_name":"A","xref_src_db":"PDBe"},{"xref_id":"1QR1","xref_name":"A","xref_src_db":"PDBe"},{"xref_id":"1S78","xref_name":"A","xref_src_db":"PDBe"},{"xref_id":"2A91","xref_name":"A","xref_src_db":"PDBe"},{"xref_id":"3BE1","xref_name":"A","xref_src_db":"PDBe"},{"xref_id":"3H3B","xref_name":"A","xref_src_db":"PDBe"},{"xref_id":"3MZW","xref_name":"A","xref_src_db":"PDBe"},{"xref_id":"3N85","xref_name":"A","xref_src_db":"PDBe"},{"xref_id":"3PP0","xref_name":"A","xref_src_db":"PDBe"},{"xref_id":"3RCD","xref_name":"A","xref_src_db":"PDBe"},{"xref_id":"3WLW","xref_name":"A","xref_src_db":"PDBe"},{"xref_id":"3WSQ","xref_name":"A","xref_src_db":"PDBe"},{"xref_id":"4GFU","xref_name":"A","xref_src_db":"PDBe"},{"xref_id":"4HRL","xref_name":"A","xref_src_db":"PDBe"},{"xref_id":"4HRM","xref_name":"A","xref_src_db":"PDBe"},{"xref_id":"4HRN","xref_name":"A","xref_src_db":"PDBe"},{"xref_id":"4NND","xref_name":"A","xref_src_db":"PDBe"},{"xref_id":"5K33","xref_name":"A","xref_src_db":"PDBe"},{"xref_id":"5KWG","xref_name":"A","xref_src_db":"PDBe"},{"xref_id":"5MY6","xref_name":"A","xref_src_db":"PDBe"},{"xref_id":"5O4G","xref_name":"A","xref_src_db":"PDBe"},{"xref_id":"5TQS","xref_name":"A","xref_src_db":"PDBe"},{"xref_id":"6ATT","xref_name":"A","xref_src_db":"PDBe"},{"xref_id":"6BGT","xref_name":"A","xref_src_db":"PDBe"},{"xref_id":"6J71","xref_name":"A","xref_src_db":"PDBe"},{"xref_id":"6LBX","xref_name":"A","xref_src_db":"PDBe"},{"xref_id":"7JXH","xref_name":"A","xref_src_db":"PDBe"},{"xref_id":"7PCD","xref_name":"A","xref_src_db":"PDBe"},{"xref_id":"7QVK","xref_name":"A","xref_src_db":"PDBe"},{"xref_id":"8JYQ","xref_name":"A","xref_src_db":"PDBe"},{"xref_id":"8JYR","xref_name":"A","xref_src_db":"PDBe"},{"xref_id":"8U8X","xref_name":"A","xref_src_db":"PDBe"},{"xref_id":"8VB5","xref_name":"A","xref_src_db":"PDBe"},{"xref_id":"9IUT","xref_name":"A","xref_src_db":"PDBe"},{"xref_id":"PF00757","xref_name":"Furin-like","xref_src_db":"Pfam"},{"xref_id":"PF01030","xref_name":"Recep_L_domain","xref_src_db":"Pfam"},{"xref_id":"PF07714","xref_name":"PK_Tyr_Ser-Thr","xref_src_db":"Pfam"},{"xref_id":"PF14843","xref_name":"GF_recep_IV","xref_src_db":"Pfam"},{"xref_id":"PF21314","xref_name":"TM_ErbB1","xref_src_db":"Pfam"},{"xref_id":"PA27844","xref_name":"erb-b2 receptor tyrosine kinase 2","xref_src_db":"PharmGKB"},{"xref_id":"P04626","xref_name":null,"xref_src_db":"Pharos"},{"xref_id":"R-HSA-1227986","xref_name":"Signaling by ERBB2","xref_src_db":"Reactome"},{"xref_id":"R-HSA-1250196","xref_name":"SHC1 events in ERBB2 signaling","xref_src_db":"Reactome"},{"xref_id":"R-HSA-1251932","xref_name":"PLCG1 events in ERBB2 signaling","xref_src_db":"Reactome"},{"xref_id":"R-HSA-1257604","xref_name":"PIP3 activates AKT signaling","xref_src_db":"Reactome"},{"xref_id":"R-HSA-1306955","xref_name":"GRB7 events in ERBB2 signaling","xref_src_db":"Reactome"},{"xref_id":"R-HSA-1358803","xref_name":"Downregulation of ERBB2:ERBB3 signaling","xref_src_db":"Reactome"},{"xref_id":"R-HSA-1963640","xref_name":"GRB2 events in ERBB2 signaling","xref_src_db":"Reactome"},{"xref_id":"R-HSA-1963642","xref_name":"PI3K events in ERBB2 signaling","xref_src_db":"Reactome"},{"xref_id":"R-HSA-2219530","xref_name":"Constitutive Signaling by Aberrant PI3K in Cancer","xref_src_db":"Reactome"},{"xref_id":"R-HSA-416572","xref_name":"Sema4D induced cell migration and growth-cone collapse","xref_src_db":"Reactome"},{"xref_id":"R-HSA-5673001","xref_name":"RAF/MAP kinase cascade","xref_src_db":"Reactome"},{"xref_id":"R-HSA-6785631","xref_name":"ERBB2 Regulates Cell Motility","xref_src_db":"Reactome"},{"xref_id":"R-HSA-6811558","xref_name":"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling","xref_src_db":"Reactome"},{"xref_id":"R-HSA-8847993","xref_name":"ERBB2 Activates PTK6 Signaling","xref_src_db":"Reactome"},{"xref_id":"R-HSA-8863795","xref_name":"Downregulation of ERBB2 signaling","xref_src_db":"Reactome"},{"xref_id":"R-HSA-8866910","xref_name":"TFAP2 (AP-2) family regulates transcription of growth factors and their receptors","xref_src_db":"Reactome"},{"xref_id":"R-HSA-9634285","xref_name":"Constitutive Signaling by Overexpressed ERBB2","xref_src_db":"Reactome"},{"xref_id":"R-HSA-9652282","xref_name":"Drug-mediated inhibition of ERBB2 signaling","xref_src_db":"Reactome"},{"xref_id":"R-HSA-9664565","xref_name":"Signaling by ERBB2 KD Mutants","xref_src_db":"Reactome"},{"xref_id":"R-HSA-9665233","xref_name":"Resistance of ERBB2 KD mutants to trastuzumab","xref_src_db":"Reactome"},{"xref_id":"R-HSA-9665244","xref_name":"Resistance of ERBB2 KD mutants to sapitinib","xref_src_db":"Reactome"},{"xref_id":"R-HSA-9665245","xref_name":"Resistance of ERBB2 KD mutants to tesevatinib","xref_src_db":"Reactome"},{"xref_id":"R-HSA-9665246","xref_name":"Resistance of ERBB2 KD mutants to neratinib","xref_src_db":"Reactome"},{"xref_id":"R-HSA-9665247","xref_name":"Resistance of ERBB2 KD mutants to osimertinib","xref_src_db":"Reactome"},{"xref_id":"R-HSA-9665249","xref_name":"Resistance of ERBB2 KD mutants to afatinib","xref_src_db":"Reactome"},{"xref_id":"R-HSA-9665250","xref_name":"Resistance of ERBB2 KD mutants to AEE788","xref_src_db":"Reactome"},{"xref_id":"R-HSA-9665251","xref_name":"Resistance of ERBB2 KD mutants to lapatinib","xref_src_db":"Reactome"},{"xref_id":"R-HSA-9665348","xref_name":"Signaling by ERBB2 ECD mutants","xref_src_db":"Reactome"},{"xref_id":"R-HSA-9665686","xref_name":"Signaling by ERBB2 TMD/JMD mutants","xref_src_db":"Reactome"},{"xref_id":"R-HSA-9665737","xref_name":"Drug resistance in ERBB2 TMD/JMD mutants","xref_src_db":"Reactome"},{"xref_id":"R-HSA-9927432","xref_name":"Developmental Lineage of Mammary Gland Myoepithelial Cells","xref_src_db":"Reactome"},{"xref_id":"R-HSA-9938206","xref_name":"Developmental Lineage of Mammary Stem Cells","xref_src_db":"Reactome"},{"xref_id":"B2RZG3","xref_name":"Receptor tyrosine-protein kinase erbB-2","xref_src_db":"UniProt"},{"xref_id":"B4DHN3","xref_name":"Receptor tyrosine-protein kinase erbB-2","xref_src_db":"UniProt"},{"xref_id":"P04626","xref_name":"Receptor tyrosine-protein kinase erbB-2","xref_src_db":"UniProt"},{"xref_id":"Q14256","xref_name":"Receptor tyrosine-protein kinase erbB-2","xref_src_db":"UniProt"},{"xref_id":"Q6LDV1","xref_name":"Receptor tyrosine-protein kinase erbB-2","xref_src_db":"UniProt"},{"xref_id":"Q9UMK4","xref_name":"Receptor tyrosine-protein kinase erbB-2","xref_src_db":"UniProt"},{"xref_id":"X5D2V5","xref_name":"Receptor tyrosine-protein kinase erbB-2","xref_src_db":"UniProt"}]}],"target_type":"SINGLE PROTEIN","tax_id":9606}]}