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not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":null,"matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"CD47","interaction_id":"KCI-CHEMBL-16668997","measurement":{"activity_id":16668997,"assay_chembl_id":"CHEMBL3855090","assay_description":"Binding affinity to CD47 receptor in human NT.115-labeled MEC1 cell membranes after 5 mins by MST assay","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL3853322","document_year":2016,"pchembl_value":"5.52","relation":"=","type":"Kd","units":"nM","value":"3040.0"},"molecule":{"canonical_smiles":"CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCCCN)C(C)C)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)O","molecule_type":"Protein","preferred_name":null,"source_molecule_id":"CHEMBL3971661","standard_inchi":"InChI=1S/C68H105N17O12S/c1-40(2)56(65(94)79-51(30-35-98-5)61(90)83-55(38-44-39-76-48-22-10-9-20-46(44)48)63(92)78-49(23-12-15-32-70)59(88)80-52(67(96)97)24-13-16-33-71)85-66(95)57(41(3)4)84-64(93)54(37-43-26-28-45(86)29-27-43)82-62(91)53(36-42-18-7-6-8-19-42)81-60(89)50(25-17-34-75-68(73)74)77-58(87)47(72)21-11-14-31-69/h6-10,18-20,22,26-29,39-41,47,49-57,76,86H,11-17,21,23-25,30-38,69-72H2,1-5H3,(H,77,87)(H,78,92)(H,79,94)(H,80,88)(H,81,89)(H,82,91)(H,83,90)(H,84,93)(H,85,95)(H,96,97)(H4,73,74,75)/t47-,49+,50+,51+,52-,53+,54+,55+,56+,57+/m1/s1","standard_inchi_key":"XEMLJJZYMPZGBS-UEUNBRMZSA-N"},"query_ids":["CH-TARGET-Q08722","CH-ACT-CHEMBL3714583","CH-MOL-CHEMBL3971661"],"source":"ChEMBL","source_target_id":"CHEMBL3714583","target_id":"T-ENSG00000196776","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"Q08722"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":null,"matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"CD47","interaction_id":"KCI-CHEMBL-16668998","measurement":{"activity_id":16668998,"assay_chembl_id":"CHEMBL3855090","assay_description":"Binding affinity to CD47 receptor in human NT.115-labeled MEC1 cell membranes after 5 mins by MST assay","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL3853322","document_year":2016,"pchembl_value":"5.92","relation":"=","type":"Kd","units":"nM","value":"1200.0"},"molecule":{"canonical_smiles":"CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(C)=O)C(C)C)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O","molecule_type":"Protein","preferred_name":null,"source_molecule_id":"CHEMBL3891508","standard_inchi":"InChI=1S/C70H108N18O12S/c1-41(2)58(68(99)83-54(31-36-101-6)64(95)86-57(39-46-40-78-49-22-11-10-21-48(46)49)66(97)82-52(25-14-17-34-73)62(93)80-50(60(74)91)23-12-15-32-71)88-69(100)59(42(3)4)87-67(98)56(38-45-27-29-47(90)30-28-45)85-65(96)55(37-44-19-8-7-9-20-44)84-63(94)53(26-18-35-77-70(75)76)81-61(92)51(79-43(5)89)24-13-16-33-72/h7-11,19-22,27-30,40-42,50-59,78,90H,12-18,23-26,31-39,71-73H2,1-6H3,(H2,74,91)(H,79,89)(H,80,93)(H,81,92)(H,82,97)(H,83,99)(H,84,94)(H,85,96)(H,86,95)(H,87,98)(H,88,100)(H4,75,76,77)/t50-,51-,52-,53-,54-,55-,56-,57-,58-,59-/m0/s1","standard_inchi_key":"YSBLDQMUSOQJJY-PVGXKDMPSA-N"},"query_ids":["CH-TARGET-Q08722","CH-ACT-CHEMBL3714583","CH-MOL-CHEMBL3891508"],"source":"ChEMBL","source_target_id":"CHEMBL3714583","target_id":"T-ENSG00000196776","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"Q08722"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":null,"matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"CD47","interaction_id":"KCI-CHEMBL-16668999","measurement":{"activity_id":16668999,"assay_chembl_id":"CHEMBL3855090","assay_description":"Binding affinity to CD47 receptor in human NT.115-labeled MEC1 cell membranes after 5 mins by MST assay","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL3853322","document_year":2016,"pchembl_value":"5.64","relation":"=","type":"Kd","units":"nM","value":"2280.0"},"molecule":{"canonical_smiles":"CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCCN)C(C)C)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O","molecule_type":"Protein","preferred_name":null,"source_molecule_id":"CHEMBL3974452","standard_inchi":"InChI=1S/C68H105N17O12S/c1-40(2)56(65(94)79-51(30-35-98-5)61(90)83-55(38-44-39-76-48-22-10-9-20-46(44)48)63(92)78-49(23-12-15-32-70)59(88)80-52(67(96)97)24-13-16-33-71)85-66(95)57(41(3)4)84-64(93)54(37-43-26-28-45(86)29-27-43)82-62(91)53(36-42-18-7-6-8-19-42)81-60(89)50(25-17-34-75-68(73)74)77-58(87)47(72)21-11-14-31-69/h6-10,18-20,22,26-29,39-41,47,49-57,76,86H,11-17,21,23-25,30-38,69-72H2,1-5H3,(H,77,87)(H,78,92)(H,79,94)(H,80,88)(H,81,89)(H,82,91)(H,83,90)(H,84,93)(H,85,95)(H,96,97)(H4,73,74,75)/t47-,49-,50-,51-,52-,53-,54-,55-,56-,57-/m0/s1","standard_inchi_key":"XEMLJJZYMPZGBS-ITJFCMOYSA-N"},"query_ids":["CH-TARGET-Q08722","CH-ACT-CHEMBL3714583","CH-MOL-CHEMBL3974452"],"source":"ChEMBL","source_target_id":"CHEMBL3714583","target_id":"T-ENSG00000196776","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"Q08722"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":null,"matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"CD47","interaction_id":"KCI-CHEMBL-16669000","measurement":{"activity_id":16669000,"assay_chembl_id":"CHEMBL3855090","assay_description":"Binding affinity to CD47 receptor in human NT.115-labeled MEC1 cell membranes after 5 mins by MST assay","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL3853322","document_year":2016,"pchembl_value":"6.11","relation":"=","type":"Kd","units":"nM","value":"771.0"},"molecule":{"canonical_smiles":"CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(=N)N)NC(C)=O)C(C)C)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(N)=O","molecule_type":"Protein","preferred_name":null,"source_molecule_id":"CHEMBL3946082","standard_inchi":"InChI=1S/C58H84N14O10S/c1-33(2)48(56(81)67-44(25-28-83-6)52(77)70-47(31-38-32-64-41-18-11-10-17-40(38)41)54(79)66-42(50(60)75)19-12-13-26-59)72-57(82)49(34(3)4)71-55(80)46(30-37-21-23-39(74)24-22-37)69-53(78)45(29-36-15-8-7-9-16-36)68-51(76)43(65-35(5)73)20-14-27-63-58(61)62/h7-11,15-18,21-24,32-34,42-49,64,74H,12-14,19-20,25-31,59H2,1-6H3,(H2,60,75)(H,65,73)(H,66,79)(H,67,81)(H,68,76)(H,69,78)(H,70,77)(H,71,80)(H,72,82)(H4,61,62,63)/t42-,43-,44-,45-,46-,47-,48-,49-/m0/s1","standard_inchi_key":"FKPSPUPLFAWXTN-XJIZABAQSA-N"},"query_ids":["CH-TARGET-Q08722","CH-ACT-CHEMBL3714583","CH-MOL-CHEMBL3946082"],"source":"ChEMBL","source_target_id":"CHEMBL3714583","target_id":"T-ENSG00000196776","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"Q08722"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":"This target contains an intracellular catalytic domain; kinase/catalytic inhibitors must not be treated as extracellular surface-site evidence.","matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"MET","interaction_id":"KCI-CHEMBL-17688600","measurement":{"activity_id":17688600,"assay_chembl_id":"CHEMBL3705882","assay_description":"In Vitro Assay: A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward primer 5'-ATTGACGGATCCATGCTAAATCCAGAGCTGGTCCAGGCA-3' (SEQ ID NO. 1) and reverse primer 5'-ACAACAGAATTCAATACGGAGCGACACATTTTACGTT-3' (SEQ ID NO. 2). The PCR product is cloned into a modified pFastBac 1 expression vector (harboring the gene for S. japonicum glutathione S-transferase immediately upstream of the multiple cloning site) using standard molecular biological techniques. The GST-c-Met kinase domain fusion (GST-Met) gene is transposed into full-length baculovirus DNA using the BacToBac system (Invitrogen). High5 cells are infected with the recombinant baculovirus for 72 h at 27 C. The infected cells are harvested by centrifugation and the pellet is stored at -80 C. The pellet is resuspended in buffer A (50 mM HEPES, pH 8.0, 0.25 M NaCl, 10 mM 2-mercaptoethanol, 10% (w/v) glycerol, 0.5% (v/v) protease.","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL3639266","document_year":2015,"pchembl_value":"10.00","relation":"=","type":"Ki","units":"nM","value":"0.1"},"molecule":{"canonical_smiles":"Fc1cc(F)cc(-c2ccc3nnc(CNc4ccnc5cc(OCCn6cncn6)cnc45)n3n2)c1","molecule_type":"Small molecule","preferred_name":null,"source_molecule_id":"CHEMBL3668200","standard_inchi":"InChI=1S/C24H18F2N10O/c25-16-7-15(8-17(26)9-16)19-1-2-22-32-33-23(36(22)34-19)12-29-20-3-4-28-21-10-18(11-30-24(20)21)37-6-5-35-14-27-13-31-35/h1-4,7-11,13-14H,5-6,12H2,(H,28,29)","standard_inchi_key":"YWAKXUWRHLXYJM-UHFFFAOYSA-N"},"query_ids":["CH-TARGET-P08581","CH-ACT-CHEMBL3717","CH-MOL-CHEMBL3668200"],"source":"ChEMBL","source_target_id":"CHEMBL3717","target_id":"T-ENSG00000105976","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"P08581"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":null,"matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"CD47","interaction_id":"KCI-CHEMBL-19306596","measurement":{"activity_id":19306596,"assay_chembl_id":"CHEMBL4415101","assay_description":"Binding affinity to CD47 in biotinylated human MEC1 cell membranes by biolayer interferometry","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL4414552","document_year":2019,"pchembl_value":"6.72","relation":"=","type":"Kd","units":"nM","value":"190.0"},"molecule":{"canonical_smiles":"CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](CCCCN)NC(=O)CCCCn1cc(CN(Cc2cn(CCCCC(=O)N[C@H](CCCCN)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCC)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)O)C(C)C)C(C)C)nn2)Cc2cn(CCCCC(=O)N[C@H](CCCCN)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCC)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)O)C(C)C)C(C)C)nn2)nn1)C(C)C)C(C)C)C(=O)N[C@H](CN[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)O)Cc1c[nH]c2ccccc12","molecule_type":"Unknown","preferred_name":null,"source_molecule_id":"CHEMBL4522427","standard_inchi":"InChI=1S/C234H359N61O38/c1-19-22-76-172(204(303)257-158(130-155-133-253-168-79-37-34-73-165(155)168)136-256-171(82-40-52-109-235)203(302)266-180(229(328)329)88-46-58-115-241)263-220(319)197(143(4)5)280-223(322)200(146(10)11)277-214(313)186(127-152-97-103-162(296)104-98-152)269-209(308)183(124-149-67-28-25-29-68-149)274-217(316)191(91-64-118-250-232(244)245)289(16)226(325)177(85-43-55-112-238)258-194(299)94-49-61-121-293-140-159(283-286-293)137-292(138-160-141-294(287-284-160)122-62-50-95-195(300)259-178(86-44-56-113-239)227(326)290(17)192(92-65-119-251-233(246)247)218(317)275-184(125-150-69-30-26-31-70-150)210(309)270-187(128-153-99-105-163(297)106-100-153)215(314)278-201(147(12)13)224(323)281-198(144(6)7)221(320)264-173(77-23-20-2)207(306)272-189(131-156-134-254-169-80-38-35-74-166(156)169)212(311)261-175(83-41-53-110-236)205(304)267-181(230(330)331)89-47-59-116-242)139-161-142-295(288-285-161)123-63-51-96-196(301)260-179(87-45-57-114-240)228(327)291(18)193(93-66-120-252-234(248)249)219(318)276-185(126-151-71-32-27-33-72-151)211(310)271-188(129-154-101-107-164(298)108-102-154)216(315)279-202(148(14)15)225(324)282-199(145(8)9)222(321)265-174(78-24-21-3)208(307)273-190(132-157-135-255-170-81-39-36-75-167(157)170)213(312)262-176(84-42-54-111-237)206(305)268-182(231(332)333)90-48-60-117-243/h25-39,67-75,79-81,97-108,133-135,140-148,158,171-193,197-202,253-256,296-298H,19-24,40-66,76-78,82-96,109-132,136-139,235-243H2,1-18H3,(H,257,303)(H,258,299)(H,259,300)(H,260,301)(H,261,311)(H,262,312)(H,263,319)(H,264,320)(H,265,321)(H,266,302)(H,267,304)(H,268,305)(H,269,308)(H,270,309)(H,271,310)(H,272,306)(H,273,307)(H,274,316)(H,275,317)(H,276,318)(H,277,313)(H,278,314)(H,279,315)(H,280,322)(H,281,323)(H,282,324)(H,328,329)(H,330,331)(H,332,333)(H4,244,245,250)(H4,246,247,251)(H4,248,249,252)/t158-,171-,172-,173-,174-,175-,176-,177+,178+,179+,180+,181+,182+,183-,184-,185-,186-,187-,188-,189-,190-,191-,192-,193-,197-,198-,199-,200-,201-,202-/m0/s1","standard_inchi_key":"BFKUAGFDBTUEHS-MCZOLVINSA-N"},"query_ids":["CH-TARGET-Q08722","CH-ACT-CHEMBL3714583","CH-MOL-CHEMBL4522427"],"source":"ChEMBL","source_target_id":"CHEMBL3714583","target_id":"T-ENSG00000196776","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"Q08722"},{"claim_ceiling":"measured ChEMBL target activity; 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not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":"This target contains an intracellular catalytic domain; kinase/catalytic inhibitors must not be treated as extracellular surface-site evidence.","matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"ERBB2","interaction_id":"KCI-CHEMBL-24962907","measurement":{"activity_id":24962907,"assay_chembl_id":"CHEMBL5216307","assay_description":"Inhibition of HER2 (unknown origin) incubated for 1 hr in presence of ATP by Kinase-Glo Plus luminescence kinase assay","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL5214926","document_year":2022,"pchembl_value":"9.85","relation":"=","type":"IC50","units":"nM","value":"0.14"},"molecule":{"canonical_smiles":"N#Cc1c(NC(=O)CNc2n[nH]c3ncccc23)sc2c1CCCC2","molecule_type":null,"preferred_name":null,"source_molecule_id":"CHEMBL5221067","standard_inchi":"InChI=1S/C17H16N6OS/c18-8-12-10-4-1-2-6-13(10)25-17(12)21-14(24)9-20-16-11-5-3-7-19-15(11)22-23-16/h3,5,7H,1-2,4,6,9H2,(H,21,24)(H2,19,20,22,23)","standard_inchi_key":"IBVURLSKTNUMDI-UHFFFAOYSA-N"},"query_ids":["CH-TARGET-P04626","CH-ACT-CHEMBL1824","CH-MOL-CHEMBL5221067"],"source":"ChEMBL","source_target_id":"CHEMBL1824","target_id":"T-ENSG00000141736","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"P04626"},{"claim_ceiling":"measured ChEMBL target activity; 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not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":"This target contains an intracellular catalytic domain; kinase/catalytic inhibitors must not be treated as extracellular surface-site evidence.","matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"MET","interaction_id":"KCI-CHEMBL-25106956","measurement":{"activity_id":25106956,"assay_chembl_id":"CHEMBL5263705","assay_description":"Inhibition of c-Met (unknown origin) using poly(Glu-Tyr) at 4:1 ratio as substrate in presence of ATP incubated for 60 mins by ELISA","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL5260829","document_year":2018,"pchembl_value":"9.92","relation":"=","type":"IC50","units":"nM","value":"0.12"},"molecule":{"canonical_smiles":"COc1ccc2c(OCc3nnc4ncc(-c5ccccc5)nn34)ccnc2c1","molecule_type":"Small molecule","preferred_name":null,"source_molecule_id":"CHEMBL3797911","standard_inchi":"InChI=1S/C21H16N6O2/c1-28-15-7-8-16-17(11-15)22-10-9-19(16)29-13-20-24-25-21-23-12-18(26-27(20)21)14-5-3-2-4-6-14/h2-12H,13H2,1H3","standard_inchi_key":"DYQKJQPOOQEANS-UHFFFAOYSA-N"},"query_ids":["CH-TARGET-P08581","CH-ACT-CHEMBL3717","CH-MOL-CHEMBL3797911"],"source":"ChEMBL","source_target_id":"CHEMBL3717","target_id":"T-ENSG00000105976","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"P08581"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":null,"matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"EPCAM","interaction_id":"KCI-CHEMBL-26218781","measurement":{"activity_id":26218781,"assay_chembl_id":"CHEMBL5651366","assay_description":"Binding affinity to human EPCAM incubated for 45 mins by Kinobead based pull down assay","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL5649169","document_year":2018,"pchembl_value":"9.33","relation":"=","type":"Kd","units":"nM","value":"0.472"},"molecule":{"canonical_smiles":"Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12","molecule_type":null,"preferred_name":null,"source_molecule_id":"CHEMBL5653589","standard_inchi":"InChI=1S/C26H20F3N7O/c1-15-8-9-16(25(37)31-19-7-3-6-18(12-19)26(27,28)29)11-21(15)32-23-20-14-36(2)35-24(20)34-22(33-23)17-5-4-10-30-13-17/h3-14H,1-2H3,(H,31,37)(H,32,33,34,35)","standard_inchi_key":"MWKSRKSEWLRPBL-UHFFFAOYSA-N"},"query_ids":["CH-TARGET-P16422","CH-ACT-CHEMBL3580493","CH-MOL-CHEMBL5653589"],"source":"ChEMBL","source_target_id":"CHEMBL3580493","target_id":"T-ENSG00000119888","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"P16422"},{"claim_ceiling":"measured ChEMBL target activity; 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IC50 values were determined from four-parameter curve fitting.","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL5725954","document_year":2018,"pchembl_value":"10.22","relation":"=","type":"IC50","units":"nM","value":"0.06"},"molecule":{"canonical_smiles":"COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(C(=O)Nc3cc(C(=O)Nc4cc(C(=O)n5ccc6cc(N)ccc65)n(C)c4)n(C)c3)n1)N=C[C@@H]1Cc3ccccc3N1C2=O","molecule_type":null,"preferred_name":null,"source_molecule_id":"CHEMBL5939267","standard_inchi":"InChI=1S/C46H43N11O7/c1-53-23-29(18-36(53)43(59)49-30-19-37(54(2)24-30)46(62)56-14-13-27-16-28(47)11-12-34(27)56)50-44(60)42-52-40(25-55(42)3)51-41(58)10-7-15-64-39-21-33-32(20-38(39)63-4)45(61)57-31(22-48-33)17-26-8-5-6-9-35(26)57/h5-6,8-9,11-14,16,18-25,31H,7,10,15,17,47H2,1-4H3,(H,49,59)(H,50,60)(H,51,58)/t31-/m0/s1","standard_inchi_key":"GOCWFVHBXZZUFO-HKBQPEDESA-N"},"query_ids":["CH-TARGET-P04626","CH-ACT-CHEMBL1824","CH-MOL-CHEMBL5939267"],"source":"ChEMBL","source_target_id":"CHEMBL1824","target_id":"T-ENSG00000141736","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"P04626"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":"This target contains an intracellular catalytic domain; kinase/catalytic inhibitors must not be treated as extracellular surface-site evidence.","matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"ERBB2","interaction_id":"KCI-CHEMBL-27038405","measurement":{"activity_id":27038405,"assay_chembl_id":"CHEMBL5731752","assay_description":"SKBR3 Cell Viability Assay for Antibody-Polymer-Drug Conjugates: PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega Corp). 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After the buffer was formulated, an enzyme and a substrate were mixed with pre-diluted compounds of varying concentrations, and placed at room temperature for 15 minutes. The reaction was initiated by adding ATP and incubated at room temperature for 60 minutes (wherein negative and positive controls were set up). The 10 μL reaction system consisted of a 2.5 μL compound, a 5 μL mixture of enzyme and substrate, and 2.5 μL ATP. After the reaction was complete, antibodies were added to test, the detection was performed with Evnvision after incubation at room temperature for 60 minutes, and data were collected. Data analysis and simulation were performed using XLfit5 software.","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL5728542","document_year":2021,"pchembl_value":"10.80","relation":"=","type":"IC50","units":"nM","value":"0.016"},"molecule":{"canonical_smiles":"COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1N1CC2(CN(C)C2)OC1=O","molecule_type":null,"preferred_name":null,"source_molecule_id":"CHEMBL5790648","standard_inchi":"InChI=1S/C21H19ClFN5O3/c1-27-8-21(9-27)10-28(20(29)31-21)16-6-12-15(7-17(16)30-2)24-11-25-19(12)26-14-5-3-4-13(22)18(14)23/h3-7,11H,8-10H2,1-2H3,(H,24,25,26)","standard_inchi_key":"DZHGHOYCGHZFFE-UHFFFAOYSA-N"},"query_ids":["CH-TARGET-P00533","CH-ACT-CHEMBL203","CH-MOL-CHEMBL5790648"],"source":"ChEMBL","source_target_id":"CHEMBL203","target_id":"T-ENSG00000146648","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"P00533"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":null,"matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"NT5E","interaction_id":"KCI-CHEMBL-28697858","measurement":{"activity_id":28697858,"assay_chembl_id":"CHEMBL5738091","assay_description":"Enzyme Activity In Vitro Assay: I. Experimental Materials and Equipment1. Malachite green phosphate detection kit (R & D Systems, Cat #, DY996)2. Recombinant human 5′-nucleotidase (CD73) (R & D Systems, Cat #, 5795-EN)3. HEPES buffer (Gibco, Cat #, 15630-080)4. CMP (Sigma, Cat #, C1006)5. DMSO (Fisher Chemical, Cat #, D128-1)6. NaCl 5M (Boston Bioproducts, Cat #, BM-244)7.384-well plate (Fisher, Cat #, 5795-EN)8. TECAN plate reader (TECAN)II. Experimental ProcedureCompounds are first dissolved in DMSO to 10 mM as a stock solution. When determining the IC50 of the compound, prepare 3-fold serial dilutions with a highest concentration of 125 μM for a total of 12 concentration points and ensure each dilution containing equal amount of DMSO. In each well of 384-well plate, 0.34 nM of recombinant human 5′-nucleotidase (CD73) was pre-incubated at 37° C. for 2 hours with the compounds tested in assay buffer containing 20 mM HEPES buffer (pH 7.4), 137 mM NaCl, 0.001% Tween 20. The final reaction volume of the reaction in each well was 12 μL. The highest concentration of compound was 125 μM and the DMSO concentration was 1.25%. After pre-incubation, 3 μL of CMP dissolved in assay buffer was added to each reaction. The final CMP concentration was 45 μM. The reaction was incubated at 37° C. for 15 minutes. Then 3 μL of Malachite Green Reagent A was added to each reaction. Spin the plate briefly in centrifuge for 30 seconds. After incubation for additional 10 minutes at room temperature, 3 μL of malachite green Reagent B was added to each reaction. Spin the plate briefly in centrifuge for 30 seconds. After 20 minutes of incubation at room temperature, the signal was read on a TECAN reader at OD620.","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL5729111","document_year":2022,"pchembl_value":"10.89","relation":"=","type":"IC50","units":"nM","value":"0.013"},"molecule":{"canonical_smiles":"O=P(O)(O)COC[C@H]1O[C@@H](n2ncc3c(N4CC5(CCc6ccccc65)C4)nc(Cl)nc32)[C@H](O)[C@@H]1O","molecule_type":null,"preferred_name":null,"source_molecule_id":"CHEMBL5431118","standard_inchi":"InChI=1S/C22H25ClN5O7P/c23-21-25-18(27-9-22(10-27)6-5-12-3-1-2-4-14(12)22)13-7-24-28(19(13)26-21)20-17(30)16(29)15(35-20)8-34-11-36(31,32)33/h1-4,7,15-17,20,29-30H,5-6,8-11H2,(H2,31,32,33)/t15-,16-,17-,20-/m1/s1","standard_inchi_key":"NAHILNAHEKBGES-WOCWXWTJSA-N"},"query_ids":["CH-TARGET-P21589","CH-ACT-CHEMBL5957","CH-MOL-CHEMBL5431118"],"source":"ChEMBL","source_target_id":"CHEMBL5957","target_id":"T-ENSG00000135318","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"P21589"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":"This target contains an intracellular catalytic domain; kinase/catalytic inhibitors must not be treated as extracellular surface-site evidence.","matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"ERBB2","interaction_id":"KCI-CHEMBL-29092486","measurement":{"activity_id":29092486,"assay_chembl_id":"CHEMBL6083475","assay_description":"Inhibition of HER2 (unknown origin)","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL6083185","document_year":2024,"pchembl_value":"10.40","relation":"=","type":"IC50","units":"nM","value":"0.04"},"molecule":{"canonical_smiles":"COc1cc2c(Nc3ccc(Oc4ccn5ncnc5c4)c(C)c3)ncnc2cc1OCCCN1CCN(CCCCCCCNc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","molecule_type":null,"preferred_name":null,"source_molecule_id":"CHEMBL6132997","standard_inchi":"InChI=1S/C49H55N11O7/c1-32-25-34(10-13-41(32)67-35-15-19-59-44(27-35)52-31-54-59)55-46-38-28-42(65-2)43(29-39(38)51-30-53-46)66-24-8-18-58-22-20-57(21-23-58)17-7-5-3-4-6-16-50-33-9-11-36-37(26-33)49(64)60(48(36)63)40-12-14-45(61)56-47(40)62/h9-11,13,15,19,25-31,40,50H,3-8,12,14,16-18,20-24H2,1-2H3,(H,51,53,55)(H,56,61,62)","standard_inchi_key":"IQCKLHMMRZVWLF-UHFFFAOYSA-N"},"query_ids":["CH-TARGET-P04626","CH-ACT-CHEMBL1824","CH-MOL-CHEMBL6132997"],"source":"ChEMBL","source_target_id":"CHEMBL1824","target_id":"T-ENSG00000141736","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"P04626"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":null,"matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"FAP","interaction_id":"KCI-CHEMBL-29108075","measurement":{"activity_id":29108075,"assay_chembl_id":"CHEMBL6087936","assay_description":"Inhibition of recombinant human FAP extracted from S2 cells immobilized on plate surface using specific antibody assessed as inhibition constant measured after 2 hrs incubation by DNA-linked Inhibitor Antibody Assay (DIANA)","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL6087393","document_year":2024,"pchembl_value":"9.96","relation":"=","type":"Ki","units":"nM","value":"0.11"},"molecule":{"canonical_smiles":"COc1ccc(CNC(=O)C(=O)[C@@H]2CCCN2C(=O)CNC(=O)c2ccnc3ccc(OCCNC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])cc23)cc1OC","molecule_type":null,"preferred_name":null,"source_molecule_id":"CHEMBL6147832","standard_inchi":"InChI=1S/C48H68N8O16/c1-62-42-8-5-36(32-43(42)63-2)34-52-48(61)46(59)41-4-3-14-56(41)45(58)35-53-47(60)38-9-11-50-40-7-6-37(33-39(38)40)72-17-12-51-44(57)10-15-64-18-20-66-22-24-68-26-28-70-30-31-71-29-27-69-25-23-67-21-19-65-16-13-54-55-49/h5-9,11,32-33,41H,3-4,10,12-31,34-35H2,1-2H3,(H,51,57)(H,52,61)(H,53,60)/t41-/m0/s1","standard_inchi_key":"JZWUOXYHHOXDSG-RWYGWLOXSA-N"},"query_ids":["CH-TARGET-Q12884","CH-ACT-CHEMBL4683","CH-MOL-CHEMBL6147832"],"source":"ChEMBL","source_target_id":"CHEMBL4683","target_id":"T-ENSG00000078098","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"Q12884"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":"This target contains an intracellular catalytic domain; kinase/catalytic inhibitors must not be treated as extracellular surface-site evidence.","matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"EGFR","interaction_id":"KCI-CHEMBL-29113767","measurement":{"activity_id":29113767,"assay_chembl_id":"CHEMBL6089387","assay_description":"Inhibition of wild type EGFR (unknown origin)","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL6087440","document_year":2025,"pchembl_value":"11.00","relation":"=","type":"IC50","units":"nM","value":"0.01"},"molecule":{"canonical_smiles":"COc1cc(N2CCC(N(C)C)CC2)ccc1Nc1ncc(C(=O)Oc2ccccc2)c(-c2c[nH]c3ccccc23)n1","molecule_type":null,"preferred_name":null,"source_molecule_id":"CHEMBL5270693","standard_inchi":"InChI=1S/C33H34N6O3/c1-38(2)22-15-17-39(18-16-22)23-13-14-29(30(19-23)41-3)36-33-35-21-27(32(40)42-24-9-5-4-6-10-24)31(37-33)26-20-34-28-12-8-7-11-25(26)28/h4-14,19-22,34H,15-18H2,1-3H3,(H,35,36,37)","standard_inchi_key":"PTQTXSUYGYJJKM-UHFFFAOYSA-N"},"query_ids":["CH-TARGET-P00533","CH-ACT-CHEMBL203","CH-MOL-CHEMBL5270693"],"source":"ChEMBL","source_target_id":"CHEMBL203","target_id":"T-ENSG00000146648","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"P00533"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":null,"matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"NT5E","interaction_id":"KCI-CHEMBL-29220906","measurement":{"activity_id":29220906,"assay_chembl_id":"CHEMBL6125220","assay_description":"Inhibition of recombinant human CD73 preincubated for 15 mins followed by AMP addition measured after 10 mins by LC/MS analysis","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL6121027","document_year":2025,"pchembl_value":"10.70","relation":"=","type":"IC50","units":"nM","value":"0.02"},"molecule":{"canonical_smiles":"Cn1nc(O[C@H](c2ccnc(OCC(F)(F)F)c2)C(F)F)c2cc(-c3n[nH]c(=O)[nH]c3=O)nnc21","molecule_type":null,"preferred_name":null,"source_molecule_id":"CHEMBL6162112","standard_inchi":"InChI=1S/C18H13F5N8O4/c1-31-14-8(5-9(26-28-14)11-15(32)25-17(33)29-27-11)16(30-31)35-12(13(19)20)7-2-3-24-10(4-7)34-6-18(21,22)23/h2-5,12-13H,6H2,1H3,(H2,25,29,32,33)/t12-/m1/s1","standard_inchi_key":"BMQDPHODVMANDJ-GFCCVEGCSA-N"},"query_ids":["CH-TARGET-P21589","CH-ACT-CHEMBL5957","CH-MOL-CHEMBL6162112"],"source":"ChEMBL","source_target_id":"CHEMBL5957","target_id":"T-ENSG00000135318","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"P21589"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":null,"matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"NT5E","interaction_id":"KCI-CHEMBL-29220907","measurement":{"activity_id":29220907,"assay_chembl_id":"CHEMBL6125220","assay_description":"Inhibition of recombinant human CD73 preincubated for 15 mins followed by AMP addition measured after 10 mins by LC/MS analysis","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL6121027","document_year":2025,"pchembl_value":"10.70","relation":"=","type":"IC50","units":"nM","value":"0.02"},"molecule":{"canonical_smiles":"Cn1nc(O[C@H](c2ccnc(OCC(F)F)c2)C(F)F)c2cc(-c3n[nH]c(=O)[nH]c3=O)nnc21","molecule_type":null,"preferred_name":null,"source_molecule_id":"CHEMBL6152291","standard_inchi":"InChI=1S/C18H14F4N8O4/c1-30-15-8(5-9(25-27-15)12-16(31)24-18(32)28-26-12)17(29-30)34-13(14(21)22)7-2-3-23-11(4-7)33-6-10(19)20/h2-5,10,13-14H,6H2,1H3,(H2,24,28,31,32)/t13-/m1/s1","standard_inchi_key":"BXKYIBVFYXIQHU-CYBMUJFWSA-N"},"query_ids":["CH-TARGET-P21589","CH-ACT-CHEMBL5957","CH-MOL-CHEMBL6152291"],"source":"ChEMBL","source_target_id":"CHEMBL5957","target_id":"T-ENSG00000135318","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"P21589"}],"schema_version":"codex-surface-known-compound-interaction-collection/v0.1","selection_contract":{"bindingdb_cutoff_nM":10,"bindingdb_helper_max_items":10,"bindingdb_limit_note":"The REST endpoint is threshold-bounded rather than page-bounded. Full threshold-matched raw payloads are retained externally; only the five lowest numeric affinities per query enter this compact collection.","bindingdb_pdb_identity_percent":100,"bindingdb_unique_molecules_selected_per_query":5,"chembl_activity_page_limit":20,"chembl_order":"descending pChEMBL, then ascending standard value, then activity ID","chembl_target_resolution":"human SINGLE PROTEIN with exact UniProt component accession","chembl_unique_molecules_selected_per_target":5,"scope":"exactly the ten Structure-A targets"},"source_inputs":{"actionable_sites":{"bytes":272569,"name":"actionable-sites.json","sha256":"07f5d2921fdf8345e0540003b0cb9ad50d8d42c349c95b2ae1dc26b2763d2897"},"structures":{"bytes":228650,"name":"structures.json","sha256":"42015660cf5e51fb59cf5159077b29a3daae6012fca9fde8307e9487815ab72d"},"targets":{"bytes":2563163,"name":"targets.json","sha256":"c6e20ca44b161b182f2c298dde20afcfb384e382a71d0926f21461aec3fd29a4"}},"source_routes":{"bindingdb":{"base_url":"https://bindingdb.org","rest_script_sha256":"ebd7c860aee32c21897192bbfab676345dc3f595781fe7a36fc0e1610e1d126b","transport":"Rosalind BindingDB skill scripts/rest_request.py"},"chembl":{"base_url":"https://www.ebi.ac.uk/chembl/api/data","rest_script_sha256":"ebd7c860aee32c21897192bbfab676345dc3f595781fe7a36fc0e1610e1d126b","transport":"Rosalind ChEMBL skill scripts/rest_request.py"}},"target_coverage":[{"chembl_target_id":"CHEMBL3714583","claim_ceiling":"bounded evidence coverage; zero selected records is not evidence of no binding","gene_symbol":"CD47","interaction_ids":["KCI-CHEMBL-16668997","KCI-CHEMBL-16668998","KCI-CHEMBL-16668999","KCI-CHEMBL-16669000","KCI-CHEMBL-19306596"],"pdb_accessions_queried":["2JJS"],"query_ids":["BDB-PDB-2JJS","BDB-UNI-Q08722","CH-ACT-CHEMBL3714583","CH-MOL-CHEMBL3891508","CH-MOL-CHEMBL3946082","CH-MOL-CHEMBL3971661","CH-MOL-CHEMBL3974452","CH-MOL-CHEMBL4522427","CH-TARGET-Q08722"],"state":"represented","target_id":"T-ENSG00000196776","uniprot_accession":"Q08722"},{"chembl_target_id":"CHEMBL3712881","claim_ceiling":"bounded evidence coverage; zero selected records is not evidence of no binding","gene_symbol":"CEACAM5","interaction_ids":[],"pdb_accessions_queried":["8BW0"],"query_ids":["BDB-PDB-8BW0","BDB-UNI-P06731","CH-ACT-CHEMBL3712881","CH-TARGET-P06731"],"state":"queried-no-selected-records","target_id":"T-ENSG00000105388","uniprot_accession":"P06731"},{"chembl_target_id":"CHEMBL203","claim_ceiling":"bounded evidence coverage; zero selected records is not evidence of no binding","gene_symbol":"EGFR","interaction_ids":["KCI-BINDINGDB-45e84700f5818806","KCI-BINDINGDB-6208f22d1f1d6c16","KCI-BINDINGDB-8e6d653dad238487","KCI-BINDINGDB-9dd515e75e406f98","KCI-BINDINGDB-d0212c8a52918ef8","KCI-CHEMBL-1043415","KCI-CHEMBL-25098086","KCI-CHEMBL-28394585","KCI-CHEMBL-28394591","KCI-CHEMBL-29113767"],"pdb_accessions_queried":["1YY9"],"query_ids":["BDB-PDB-1YY9","BDB-UNI-P00533","CH-ACT-CHEMBL203","CH-MOL-CHEMBL176582","CH-MOL-CHEMBL4650319","CH-MOL-CHEMBL5270693","CH-MOL-CHEMBL5746224","CH-MOL-CHEMBL5790648","CH-TARGET-P00533"],"state":"represented","target_id":"T-ENSG00000146648","uniprot_accession":"P00533"},{"chembl_target_id":"CHEMBL3580493","claim_ceiling":"bounded evidence coverage; zero selected records is not evidence of no binding","gene_symbol":"EPCAM","interaction_ids":["KCI-BINDINGDB-5116757b4315b4d0","KCI-CHEMBL-26218781"],"pdb_accessions_queried":["6I07"],"query_ids":["BDB-PDB-6I07","BDB-UNI-P16422","CH-ACT-CHEMBL3580493","CH-MOL-CHEMBL5653589","CH-TARGET-P16422"],"state":"represented","target_id":"T-ENSG00000119888","uniprot_accession":"P16422"},{"chembl_target_id":"CHEMBL1824","claim_ceiling":"bounded evidence coverage; 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zero selected records is not evidence of no binding","gene_symbol":"GUCY2C","interaction_ids":[],"pdb_accessions_queried":["8GHP"],"query_ids":["BDB-PDB-8GHP","BDB-UNI-P25092","CH-ACT-CHEMBL1795197","CH-TARGET-P25092"],"state":"queried-no-selected-records","target_id":"T-ENSG00000070019","uniprot_accession":"P25092"},{"chembl_target_id":"CHEMBL3717","claim_ceiling":"bounded evidence coverage; zero selected records is not evidence of no binding","gene_symbol":"MET","interaction_ids":["KCI-BINDINGDB-07b5180568b7a80a","KCI-BINDINGDB-086ad40138f8ffc9","KCI-BINDINGDB-7e6ba957e80bed5b","KCI-BINDINGDB-e5a7cd86571d5244","KCI-BINDINGDB-e5c5966f67a1df06","KCI-CHEMBL-15614613","KCI-CHEMBL-17688600","KCI-CHEMBL-24687320","KCI-CHEMBL-24687321","KCI-CHEMBL-25106956"],"pdb_accessions_queried":["4K3J"],"query_ids":["BDB-PDB-4K3J","BDB-UNI-P08581","CH-ACT-CHEMBL3717","CH-MOL-CHEMBL3582305","CH-MOL-CHEMBL3668200","CH-MOL-CHEMBL3797911","CH-MOL-CHEMBL5174958","CH-MOL-CHEMBL5184459","CH-TARGET-P08581"],"state":"represented","target_id":"T-ENSG00000105976","uniprot_accession":"P08581"},{"chembl_target_id":"CHEMBL5957","claim_ceiling":"bounded evidence coverage; zero selected records is not evidence of no binding","gene_symbol":"NT5E","interaction_ids":["KCI-BINDINGDB-28c1c93d467d5e41","KCI-BINDINGDB-29aeb14112f4c59d","KCI-BINDINGDB-4ca4e279a02ca5b9","KCI-BINDINGDB-737fe486bdd27f84","KCI-BINDINGDB-fb5a19e615ed96ca","KCI-CHEMBL-22396873","KCI-CHEMBL-22396878","KCI-CHEMBL-28697858","KCI-CHEMBL-29220906","KCI-CHEMBL-29220907"],"pdb_accessions_queried":["7BBJ","9R0G"],"query_ids":["BDB-PDB-7BBJ","BDB-PDB-9R0G","BDB-UNI-P21589","CH-ACT-CHEMBL5957","CH-MOL-CHEMBL4471306","CH-MOL-CHEMBL4761506","CH-MOL-CHEMBL5431118","CH-MOL-CHEMBL6152291","CH-MOL-CHEMBL6162112","CH-TARGET-P21589"],"state":"represented","target_id":"T-ENSG00000135318","uniprot_accession":"P21589"},{"chembl_target_id":"CHEMBL3856163","claim_ceiling":"bounded evidence coverage; zero selected records is not evidence of no binding","gene_symbol":"TACSTD2","interaction_ids":[],"pdb_accessions_queried":["9PI9"],"query_ids":["BDB-PDB-9PI9","BDB-UNI-P09758","CH-ACT-CHEMBL3856163","CH-TARGET-P09758"],"state":"queried-no-selected-records","target_id":"T-ENSG00000184292","uniprot_accession":"P09758"}],"unresolved":[{"error":"Request failed for bindingdb-skill: HTTPError","gene_symbol":"GUCY2C","query_id":"BDB-PDB-8GHP","source":"BindingDB","state":"query-failed","target_id":"T-ENSG00000070019"},{"error":"Request failed for bindingdb-skill: HTTPError","gene_symbol":"CEACAM5","query_id":"BDB-PDB-8BW0","source":"BindingDB","state":"query-failed","target_id":"T-ENSG00000105388"},{"error":"Request failed for bindingdb-skill: HTTPError","gene_symbol":"EPCAM","query_id":"BDB-PDB-6I07","source":"BindingDB","state":"query-failed","target_id":"T-ENSG00000119888"},{"error":"Request failed for bindingdb-skill: HTTPError","gene_symbol":"NT5E","query_id":"BDB-PDB-7BBJ","source":"BindingDB","state":"query-failed","target_id":"T-ENSG00000135318"},{"error":"Request failed for bindingdb-skill: HTTPError","gene_symbol":"NT5E","query_id":"BDB-PDB-9R0G","source":"BindingDB","state":"query-failed","target_id":"T-ENSG00000135318"},{"error":"Request failed for bindingdb-skill: HTTPError","gene_symbol":"EGFR","query_id":"BDB-PDB-1YY9","source":"BindingDB","state":"query-failed","target_id":"T-ENSG00000146648"},{"error":"Request failed for bindingdb-skill: HTTPError","gene_symbol":"TACSTD2","query_id":"BDB-PDB-9PI9","source":"BindingDB","state":"query-failed","target_id":"T-ENSG00000184292"},{"error":"Request failed for bindingdb-skill: HTTPError","gene_symbol":"CD47","query_id":"BDB-PDB-2JJS","source":"BindingDB","state":"query-failed","target_id":"T-ENSG00000196776"}]},"preprints.json":{"atlas_id":"pmmr-mucinous-colon","claim_ceiling":"preprint-discovery-evidence","counts":{"cached_biorxiv_skill_calls_reused":13,"cached_europe_pmc_queries_reused":40,"completed_queries":40,"duplicate_query_memberships":4,"hydrated_query_memberships":10,"hydrated_unique_preprints":6,"non_10_1101_doi_records":10,"non_10_1101_duplicate_query_memberships":3,"non_10_1101_query_memberships":10,"normalized_unique_preprints":13,"raw_query_memberships":20,"records_missing_doi":0,"registered_queries":40,"server_counts":{"biorxiv":5,"medrxiv":1},"truncated_queries":0,"unique_10_1101_dois":6,"unique_non_10_1101_dois":7,"unresolved_unique_preprints":0},"coverage_state":"complete-with-explicit-query-cutoffs","discovery_transport":{"base_url":"https://www.ebi.ac.uk/europepmc/webservices/rest","limitation":"Each registered concept is limited to the top 100 Europe PMC results; a truncated query is not exhaustive beyond that cutoff.","per_query_record_cap":100,"publication_filter":"PUB_TYPE:Preprint","result_type":"core","source":"Europe PMC REST search"},"evidence_cutoff":"2026-09-04","generated_at":"2026-09-04","hydration_transport":{"base_url":"https://api.biorxiv.org","source":"bioRxiv/medRxiv API","transport":"life-sciences-literature:biorxiv-skill/scripts/rest_request.py"},"other_preprints":[{"canonical_url":"https://doi.org/10.21203/rs.3.rs-1861874/v1","claim_ceiling":"preprint-discovery-evidence","doi":"10.21203/rs.3.rs-1861874/v1","europe_pmc_metadata":{"abstractText":"Background:
The aim of this study was to develop comprehensive and effective nomograms for predicting overall survival (OS) and cancer-specific survival (CSS) rates in patients with colorectal mucinous adenocarcinoma (CRMA). MethodsA total of 4711 CRMA patients who underwent radical surgery between 2010 and 2018 from the Surveillance, Epidemiology, and End Results (SEER) database were collected and randomized into development (n=3,299) and validation (n=1,412) cohorts at a ratio of 7:3 for model development and validation. OS and CSS nomograms were developed using the prognostic factors from the development cohort after multivariable Cox regression analysis. The performance of the nomograms was evaluated using Harrell’s concordance index (C-index), calibration diagrams, receiver operating characteristic (ROC) curves, and decision curve analysis (DCA).ResultsThe study included 4,711 patients. Multivariate Cox regression analysis demonstrated that age, tumor size, grade, pT stage, pN stage, M stage, carcinoembryonic antigen, perineural invasion, tumor deposits, regional nodes examined, and chemotherapy were correlated with OS and CSS. Marital status was independently related to OS. In the development and validation cohorts, the C-index of OS was 0.766 and 0.744, respectively, and the C-index of CSS was 0.826 and 0.809, respectively. Calibration curves and ROC curves showed predictive accuracy. DCA showed that the nomograms had excellent potency over the 8th edition of TNM staging system with higher clinical net benefits. Significant differences in OS and CSS were observed among low-, medium-, and high-risk groups.ConclusionsNomograms were developed for the first time to predict personalized 1-, 3-, and 5-year OS and CSS in CRMA postoperative patients. External and internal validation confirmed the excellent discrimination and calibration ability of the nomograms. The nomograms can help clinicians design personalized treatment strategies and assist with clinical decisions.","authorString":"Wang P, Song Q, Lu M, Xia Q, Wang Z, Zhao Q, Ma X.","bookOrReportDetails":{"publisher":"Research Square","yearOfPublication":2022},"doi":"10.21203/rs.3.rs-1861874/v1","firstIndexDate":"2022-07-27","firstPublicationDate":"2022-07-26","hasEvaluations":"N","id":"PPR523941","pubTypeList":{"pubType":["Preprint"]},"source":"PPR","title":"Establishment and validation of a postoperative predictive model for patients with colorectal mucinous adenocarcinoma","versionList":{"version":[{"firstPublishDate":"2022-07-26","hasEvaluations":"N","id":"PPR523941","pubTypeList":{"pubType":["preprint"]},"source":"PPR","versionNumber":1}]},"versionNumber":1},"hydration_state":"not-requested-non-10.1101-doi","preprint_id":"DOI:10.21203/rs.3.rs-1861874/v1","query_memberships":[{"discovery_position":7,"query_family":"disease-association","query_id":"Q-BIORXIV-01","query_scope":"core-disease"}]},{"canonical_url":"https://doi.org/10.21203/rs.3.rs-21102/v2","claim_ceiling":"preprint-discovery-evidence","doi":"10.21203/rs.3.rs-21102/v2","europe_pmc_metadata":{"abstractText":"Abstract Background: The prognostic value of the mucinous adenocarcinoma histotype on the early stages especially for stage I colorectal cancer (CRC) is still unclear. This study determined the clinicopathologic characteristics and long-term outcome of stage I colorectal mucinous adenocarcinomas (MAC). Methods: Among the total of 503 patients with stage I CRC (56 having MAC and 447 having non-MAC) who underwent radical resection, the correlation between clinicopathological factors and MAC was analyzed. Multivariate analysis was performed to determine whether mucinous histotype itself was an independent prognostic impact in stage I patients. Results: MACs were observed more frequently located in the colon than rectum (p=0.046), more frequently displayed the microsatellite instability (MSI) phenotype (p=0.023) and had a greater frequency of T2 stage (p=0.001). The rate of recurrence was 13.5% and the cancer-specific mortality was 4.3% among all stage I CRC patients. There was no difference in disease-free survival and overall survival between MACs and non-MACs. On multivariate analysis, older age (p=0.030，hazard ratio: 2.62), rectal cancer (p=0.025, hazard ratio: 5.42), lymphovascular invasion (LVI) (p<0.001, hazard ratio: 9.74), and microsatellite stability (MSS) phenotypes (p=0.023, hazard ratio: 4.21) were independently associated to poor survival of stage I CRC. A high carcinoembryonic antigen (CEA) level (p=0.031, hazard ratio: 1.95), rectal cancer (p=0.045, hazard ratio: 1.64), LVI (p=0.002, hazard ratio: 3.95) and MSS phenotypes (p=0.012, hazard ratio: 2.98) were independently related to short disease-free survival of stage I CRC.Conclusions: Compared with non-MAC, MAC patients had more T2 patients and more MSI phenotypes in stage I CRC at presentation, but the mucinous histology is not a significant predictor of recurrence and prognosis in stage I CRC.
","authorString":"Huang L, Luo S, Lai S, Cai Y, Liu Z, Hu H, Zeng Z, Xian CJ, Dong J, Wang L, Kang L.","bookOrReportDetails":{"publisher":"Research Square","yearOfPublication":2020},"doi":"10.21203/rs.3.rs-21102/v2","firstIndexDate":"2020-06-23","firstPublicationDate":"2020-06-22","hasEvaluations":"N","id":"PPR178802","pubTypeList":{"pubType":["Preprint"]},"source":"PPR","title":"Survival after Curative Resection for Stage I Colorectal Mucinous Adenocarcinoma","versionList":{"version":[{"firstPublishDate":"2020-04-08","hasEvaluations":"N","id":"PPR147303","pubTypeList":{"pubType":["preprint"]},"source":"PPR","versionNumber":1},{"firstPublishDate":"2020-06-22","hasEvaluations":"N","id":"PPR178802","pubTypeList":{"pubType":["preprint"]},"source":"PPR","versionNumber":2}]},"versionNumber":2},"hydration_state":"not-requested-non-10.1101-doi","preprint_id":"DOI:10.21203/rs.3.rs-21102/v2","query_memberships":[{"discovery_position":8,"query_family":"disease-association","query_id":"Q-BIORXIV-01","query_scope":"core-disease"}]},{"canonical_url":"https://doi.org/10.21203/rs.3.rs-2255993/v1","claim_ceiling":"preprint-discovery-evidence","doi":"10.21203/rs.3.rs-2255993/v1","europe_pmc_metadata":{"abstractText":"Abstract There is currently an urgent need to identify factors predictive of immunogenicity in colorectal cancer (CRC). Mucinous CRC is a distinct histological subtype of CRC, associated with a poor response to chemotherapy. Recent evidence suggests the commensal facultative anaerobe Fusobacterium may be especially prevalent in mucinous CRC. The objectives of this study were to assess the impact of Fusobacterium prevalence on immune cell expression and prognosis in mucinous CRC. Our study included two independent colorectal cancer patient cohorts, The Cancer Genome Atlas (TCGA) cohort, and a cohort of rectal cancers from the Beaumont RCSI Cancer Centre (BRCC). Multiplexed immunofluorescence staining of a tumor microarray (TMA) from the BRCC cohort was undertaken using Cell DIVE technology. Our cohorts included 87 cases (13.3%) of mucinous and 565 cases (86.7%) of non-mucinous CRC. Mucinous CRC in the TCGA dataset was associated with increased CD8 + lymphocyte (p = 0.018), regulatory T-cell (p = 0.001) and M2 macrophage (p = 0.001) expression. Similarly in the BRCC cohort, mucinous RC was associated with enhanced CD8 + lymphocyte (p = 0.022), regulatory T-cell (p = 0.047), and B-cell (p = 0.025) counts. Elevated Fusobacterium expression was associated with increased CD4+ (p = 0.031) and M1 macrophage (p = 0.006) expression, whilst M2 macrophages (p = 0.043) were under-expressed in the TCGA cohort. Increased Fusobacterium relative abundance in mucinous CRC was associated with improved clinical outcomes in our TCGA cohort despite having no association with MSI status (DSS: likelihood ratio p = 0.04, logrank p = 0.052). Fusobacterium abundance is associated with improved outcomes in mucinous CRC, possibly due its modulatory effect on the host immune response.
","authorString":"Duggan WP, Salvucci M, Kisakol B, Lindner AU, Reynolds IS, Dussmann H, Fay J, O'Grady T, Longley DB, Ginty F, McDonough E, Slade DJ, Burke JP, Prehn JHM.","bookOrReportDetails":{"publisher":"Research Square","yearOfPublication":2022},"doi":"10.21203/rs.3.rs-2255993/v1","firstIndexDate":"2022-11-26","firstPublicationDate":"2022-11-23","hasEvaluations":"N","id":"PPR575984","pubTypeList":{"pubType":["Preprint"]},"source":"PPR","title":"Patients with Increased Levels of Fusobacterium Tumoral Abundance are Associated with Better Outcomes in Mucinous Colorectal Cancer.","versionList":{"version":[{"firstPublishDate":"2022-11-23","hasEvaluations":"N","id":"PPR575984","pubTypeList":{"pubType":["preprint"]},"source":"PPR","versionNumber":1}]},"versionNumber":1},"hydration_state":"not-requested-non-10.1101-doi","preprint_id":"DOI:10.21203/rs.3.rs-2255993/v1","query_memberships":[{"discovery_position":8,"query_family":"surface-identity","query_id":"Q-BIORXIV-11","query_scope":"core-disease"}]},{"canonical_url":"https://doi.org/10.21203/rs.3.rs-3033737/v1","claim_ceiling":"preprint-discovery-evidence","doi":"10.21203/rs.3.rs-3033737/v1","europe_pmc_metadata":{"abstractText":"Background:
Mucinous adenocarcinoma (MC) of colorectal cancer (CRC) differs from adenocarcinoma (AD) in clinical features and molecular characteristics. Current treatment of colorectal MC isn't precise enough and the molecular characteristics remain unclear. Methods We accessed the data of CRC patients from The Cancer Genome Atlas (TCGA) database, then we performed differential analysis and weighted gene co-expression network analysis (WGCNA) to identify the differential hub RNAs between colorectal MC and AD. Functional enrichment analysis, RNAs co-expression networks, risk score based on least absolute shrinkage and selection operator (LASSO) regression model and validation in Gene Expression Omnibus (GEO) database, survival analysis were also performed. Finally, differential hub lncRNAs and hub RNA of significant module were validated by quantitative real time PCR (qRT-PCR) among different colon cancer cell lines. Results In total, we found 1680 differential expressed RNAs (DERs) and 4 significant modules (darkred, magenta, lightstellblue1, tan) comparing colorectal MC (52, 13.3%) with AD (340, 86.7%). From the functional enrichment analysis and RNAs co-expression networks, the darkred module was considered as a mucin-associated module, while others may be associated with other features of colorectal MC. Construction of logistic regression model and calculation of risk score based on differential hub RNAs in darkred module showed acceptable result in both TCGA and GEO data. Survival analysis suggested that many differential hub RNAs were positive and correlated with better survival. Finally, 8 differential hub RNAs in the darkred module (CTD-2547H18.1, CTD-2589M5.4, RP11-234B24.2, LA16c-321D4.2, LINC00261, RP11-25K19.1, COLCA1 and CAPN9) were validated by qRT-PCR. Except for LA16c-321D4.2 and COLCA1, all other RNAs showed higher expression levels in mucin-producing colorectal cell lines (Ls174T, HT-29 and T84). Conclusion The study strengthens the findings of distinct molecular features between MC and AD in CRC and identifies potential marker RNAs making colorectal MC unique from AD. The genesis of colorectal MC may be related to the differentiation fate of intestinal goblet cells.","authorString":"Liu J, Qiu S, Fu X, Zhou B, Zu R, Lv Z, Li Y, Yang L, Zhou Z.","bookOrReportDetails":{"publisher":"Research Square","yearOfPublication":2023},"doi":"10.21203/rs.3.rs-3033737/v1","firstIndexDate":"2023-06-14","firstPublicationDate":"2023-06-12","hasEvaluations":"N","id":"PPR674705","pubTypeList":{"pubType":["Preprint"]},"source":"PPR","title":"Transcriptomic Landscape Of Colorectal Mucinous Adenocarcinoma Has Similarity With Intestinal Goblet Cells Differentiation","versionList":{"version":[{"firstPublishDate":"2023-06-12","hasEvaluations":"N","id":"PPR674705","pubTypeList":{"pubType":["preprint"]},"source":"PPR","versionNumber":1}]},"versionNumber":1},"hydration_state":"not-requested-non-10.1101-doi","preprint_id":"DOI:10.21203/rs.3.rs-3033737/v1","query_memberships":[{"discovery_position":6,"query_family":"disease-association","query_id":"Q-BIORXIV-01","query_scope":"core-disease"},{"discovery_position":7,"query_family":"surface-identity","query_id":"Q-BIORXIV-11","query_scope":"core-disease"}]},{"canonical_url":"https://doi.org/10.21203/rs.3.rs-3212530/v1","claim_ceiling":"preprint-discovery-evidence","doi":"10.21203/rs.3.rs-3212530/v1","europe_pmc_metadata":{"abstractText":"Background:
Mucinous adenocarcinoma (MC) of colorectal cancer (CRC) differs from adenocarcinoma (AD) in clinical features and molecular characteristics. Current treatment of colorectal MC isn't precise enough and the molecular characteristics remain unclear. The study aims to explore the difference between MC and AD of CRC on transcriptome level, for possibility of treating colorectal MC precisely. Methods We accessed the data of CRC patients from The Cancer Genome Atlas (TCGA) database, then we performed differential analysis and weighted gene co-expression network analysis (WGCNA) to identify the differential hub RNAs between colorectal MC and AD. Functional enrichment analysis, RNAs co-expression networks, risk score based on least absolute shrinkage and selection operator (LASSO) regression model and validation in Gene Expression Omnibus (GEO) database, survival analysis were also performed. Finally, differential hub lncRNAs and hub RNA of significant module were validated by quantitative real time PCR (qRT-PCR) among different colon cancer cell lines. Results In total, we found 1680 differential expressed RNAs (DERs) and 4 significant modules (darkred, magenta, lightstellblue1, tan) comparing colorectal MC (52, 13.3%) with AD (340, 86.7%). From the functional enrichment analysis and RNAs co-expression networks, the darkred module was considered as a mucin-associated module, while some others may be associated with unique immune progress. Construction of logistic regression model and calculation of risk score based on differential hub RNAs in darkred module showed acceptable result in both TCGA and GEO data. Survival analysis suggested that many differential hub RNAs were positive and correlated with better survival. Finally, 8 differential hub RNAs in the darkred module (CTD-2547H18.1, CTD-2589M5.4, RP11-234B24.2, LA16c-321D4.2, LINC00261, RP11-25K19.1, COLCA1 and CAPN9) were validated by qRT-PCR. Except for LA16c-321D4.2 and COLCA1, all other RNAs showed higher expression levels in mucin-producing colorectal cell lines (Ls174T, HT-29 and T84). Conclusion This study suggests that clinical treatments for colorectal MC should be differentiated from AD. Further exploration of enterocyte (goblet cell) differentiation with tumor genesis and the distinct immune progression of MC may help to identify key therapeutic targets for colorectal MC. Further research into the application of immunotherapy to colorectal MC is needed.","authorString":"Liu J, Qiu S, Fu X, Zhou B, Zu R, Lv Z, Li Y, Yang L, Zhou Z.","bookOrReportDetails":{"publisher":"Research Square","yearOfPublication":2023},"doi":"10.21203/rs.3.rs-3212530/v1","firstIndexDate":"2023-08-31","firstPublicationDate":"2023-08-23","hasEvaluations":"N","id":"PPR709776","pubTypeList":{"pubType":["Preprint"]},"source":"PPR","title":"Clinical Treatment Of Colorectal Mucinous Adenocarcinoma Could Be Discriminate From Adenocarcinoma: Genesis And Immune Microenvironment Differences On Transcript Level","versionList":{"version":[{"firstPublishDate":"2023-08-23","hasEvaluations":"N","id":"PPR709776","pubTypeList":{"pubType":["preprint"]},"source":"PPR","versionNumber":1}]},"versionNumber":1},"hydration_state":"not-requested-non-10.1101-doi","preprint_id":"DOI:10.21203/rs.3.rs-3212530/v1","query_memberships":[{"discovery_position":4,"query_family":"disease-association","query_id":"Q-BIORXIV-01","query_scope":"core-disease"},{"discovery_position":6,"query_family":"surface-identity","query_id":"Q-BIORXIV-11","query_scope":"core-disease"}]},{"canonical_url":"https://doi.org/10.21203/rs.3.rs-9746720/v1","claim_ceiling":"preprint-discovery-evidence","doi":"10.21203/rs.3.rs-9746720/v1","europe_pmc_metadata":{"abstractText":"Abstract Background: In recent years, only a few cases of mucinous adenocarcinoma with signet-ring cell carcinoma (MAC-SRC) have been reported, and detailed endoscopic imaging features remain poorly characterized. This is likely because these tumors are often already at an advanced stage at diagnosis, rendering endoscopic examination infeasible. We herein report a young Asian male diagnosed with sigmoid colon MAC-SRC (60% mucinous adenocarcinoma, 40% signet-ring cell carcinoma). Case presentation: A 27-year-old male presented with recurrent vomiting for 20 days. Abdominal computed tomography showed marked thickening of the sigmoid colon wall. Colonoscopy demonstrated luminal stenosis and rigidity, with extensive erosive lesions covered by abundant, difficult-to-irrigate white mucus; the lesion measured 8 cm in length. Biopsy confirmed mucinous adenocarcinoma. The patient underwent left hemicolectomy, and postoperative pathology verified MAC-SRC. Two months after initiating chemotherapy, the patient was in good condition, with occasional abdominal distension and a weight gain of 2.5 kg. Conclusions: Compared with conventional adenocarcinoma, MAC-SRC in young patients shows distinct clinical features and carries a high risk of missed diagnosis. Colonoscopy with adequate biopsy is essential. This patient initially presented with upper gastrointestinal symptoms, leading to a delay in diagnosis. Timely intervention was initiated following endoscopic detection of mucosal abnormalities and confirmatory biopsy findings. The endoscopic characteristics we describe provide diagnostic evidence for MAC-SRC and have important clinical implications.
","authorString":"Liu Y, Zeng W, Ma S, Cao H.","bookOrReportDetails":{"publisher":"Research Square","yearOfPublication":2026},"doi":"10.21203/rs.3.rs-9746720/v1","firstIndexDate":"2026-06-03","firstPublicationDate":"2026-05-31","hasEvaluations":"N","id":"PPR1242577","pubTypeList":{"pubType":["Preprint"]},"source":"PPR","title":"Colorectal mucinous adenocarcinoma with signet-ring cells: a case report","versionList":{"version":[{"firstPublishDate":"2026-05-31","hasEvaluations":"N","id":"PPR1242577","pubTypeList":{"pubType":["preprint"]},"source":"PPR","versionNumber":1}]},"versionNumber":1},"hydration_state":"not-requested-non-10.1101-doi","preprint_id":"DOI:10.21203/rs.3.rs-9746720/v1","query_memberships":[{"discovery_position":2,"query_family":"surface-identity","query_id":"Q-BIORXIV-11","query_scope":"core-disease"}]},{"canonical_url":"https://doi.org/10.64898/2026.03.02.709044","claim_ceiling":"preprint-discovery-evidence","doi":"10.64898/2026.03.02.709044","europe_pmc_metadata":{"abstractText":"Mucinous colorectal carcinoma (CRC) is a distinct histomorphological subtype characterized by abundant extracellular mucin that may promote immune evasion and chemoresistance. We describe a metastatic mucinous CRC case integrating digital pathology and proteomics to investigate disease progression and therapy resistance. Formalin-fixed paraffin-embedded samples from the primary tumor, peritoneal metastasis, and hepatoduodenal ligament metastasis of a 56-year-old patient were analyzed. Whole-slide imaging with QuPath-based AI enabled detailed histological annotation, while data-independent acquisition mass spectrometry identified over 6,000 proteins. Digital pathology revealed extensive mucin pools, architectural evolution from heterogeneous glandular patterns in the primary tumor to cribriform morphology in advanced metastases, and immune cell exclusion from mucin-rich regions. Proteomics revealed metabolic reprogramming, suppressed antigen presentation, and stage-specific activation of inflammatory, angiogenic, EMT, and PI3K/AKT/mTOR–MYC signaling pathways, consistent with proliferative and therapy-resistant phenotypes.Integration of AI-assisted histopathology with spatial proteomics highlighted the mucin barrier as a key mediator of immune evasion and chemoresistance. These findings support a personalized therapeutic framework targeting mucin-associated mechanisms alongside pathway-directed inhibitors, suggesting that spatial multi-omics may guide precision management strategies for aggressive mucinous colorectal cancer.","authorString":"Fülöp L, Szigeti B, Guedes J, Woldmar N, Oskolás H, Marko-Varga M, Appelqvist R, Wieslander E, Pawlowski K, Szadai L, Christersson L, Malm J, Németh IB, Szasz MA, Gil J, Marko-Varga G.","bookOrReportDetails":{"publisher":"bioRxiv","yearOfPublication":2026},"doi":"10.64898/2026.03.02.709044","firstIndexDate":"2026-05-19","firstPublicationDate":"2026-03-04","hasEvaluations":"N","id":"PPR1221412","pubTypeList":{"pubType":["Preprint"]},"source":"PPR","title":"Proteomics-Enhanced AI-Digital Pathology in Metastatic Mucinous Colorectal Carcinoma: A Case 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15% of colorectal cancers (CRC) cells exhibit a mucin hypersecretory phenotype, which is suggested to provide resistance to immune surveillance and chemotherapy. We now formally show that colorectal cancer cells build a barrier to chemotherapeutics by increasing mucins’ secretion. We show that low levels of KChIP3, a negative regulator of mucin secretion (Cantero-Recasens et al ., 2018), is a risk factor for CRC patients’ relapse in subset of untreated tumours. Our results also reveal that cells depleted of KChIP3 are four times more resistant (measured as cell viability and DNA damage) to chemotherapeutics 5-Fluorouracil plus Irinotecan (5-FU+iri.) compared to control cells, whereas KChIP3 overexpressing cells are 10 times more sensitive to killing by chemotherapeutics. Similar increase in tumour cell death is observed upon chemical inhibition of mucin secretion by the sodium/calcium exchanger (NCX) blockers (Mitrovic et al ., 2013). Finally, sensitivity of CRC patient-derived organoids to 5-FU+iri increases 40-fold upon mucin secretion inhibition. Reducing mucin secretion thus provides a means to control chemoresistance of mucinous colorectal cancer cells and other mucinous tumours.","authorString":"Cantero-Recasens G, Alonso-Marañón J, Lobo-Jarne T, Garrido M, Iglesias M, Espinosa L, Malhotra V.","bookOrReportDetails":{"publisher":"bioRxiv","yearOfPublication":2021},"doi":"10.1101/2021.09.17.460827","firstIndexDate":"2021-09-20","firstPublicationDate":"2021-09-19","hasEvaluations":"Y","id":"PPR396484","pubTypeList":{"pubType":["Preprint"]},"source":"PPR","title":"Reversing chemorefraction in colorectal cancer cells by controlling mucin secretion"},"hydration":{"latest_version":{"abstract":"15% of colorectal cancers (CRC) cells exhibit a mucin hypersecretory phenotype, which is suggested to provide resistance to immune surveillance and chemotherapy. We now formally show that colorectal cancer cells build a barrier to chemotherapeutics by increasing mucins secretion. We show that low levels of KChIP3, a negative regulator of mucin secretion (Cantero-Recasens et al., 2018), is a risk factor for CRC patients relapse in subset of untreated tumours. Our results also reveal that cells depleted of KChIP3 are four times more resistant (measured as cell viability and DNA damage) to chemotherapeutics 5-Fluorouracil plus Irinotecan (5-FU+iri.) compared to control cells, whereas KChIP3 overexpressing cells are 10 times more sensitive to killing by chemotherapeutics. Similar increase in tumour cell death is observed upon chemical inhibition of mucin secretion by the sodium/calcium exchanger (NCX) blockers (Mitrovic et al., 2013). Finally, sensitivity of CRC patient-derived organoids to 5-FU+iri increases 40-fold upon mucin secretion inhibition. 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We now formally show that colorectal cancer cells build a barrier to chemotherapeutics by increasing mucins secretion. We show that low levels of KChIP3, a negative regulator of mucin secretion (Cantero-Recasens et al., 2018), is a risk factor for CRC patients relapse in subset of untreated tumours. Our results also reveal that cells depleted of KChIP3 are four times more resistant (measured as cell viability and DNA damage) to chemotherapeutics 5-Fluorouracil plus Irinotecan (5-FU+iri.) compared to control cells, whereas KChIP3 overexpressing cells are 10 times more sensitive to killing by chemotherapeutics. Similar increase in tumour cell death is observed upon chemical inhibition of mucin secretion by the sodium/calcium exchanger (NCX) blockers (Mitrovic et al., 2013). Finally, sensitivity of CRC patient-derived organoids to 5-FU+iri increases 40-fold upon mucin secretion inhibition. Reducing mucin secretion thus provides a means to control chemoresistance of mucinous colorectal cancer cells and other mucinous tumours.","author_corresponding":"Gerard Cantero-Recasens","author_corresponding_institution":"Vall d'Hebron Research Institute","authors":"Cantero-Recasens, G.; Alonso-Maranon, J.; Lobo-Jarne, T.; Garrido, M.; Iglesias, M.; Espinosa, L.; Malhotra, V.","category":"cell biology","date":"2021-09-19","doi":"10.1101/2021.09.17.460827","jatsxml":"https://www.biorxiv.org/content/early/2021/09/19/2021.09.17.460827.source.xml","license":"cc_by","published":"10.7554/eLife.73926","server":"bioRxiv","title":"Reversing chemorefraction in colorectal cancer cells by controlling mucin secretion","type":"new results","version":"1"}]},"preprint_id":"DOI:10.1101/2021.09.17.460827","query_memberships":[{"discovery_position":9,"query_family":"surface-identity","query_id":"Q-BIORXIV-11","query_scope":"core-disease"}]},{"canonical_url":"https://doi.org/10.1101/2022.12.22.521159","claim_ceiling":"preprint-discovery-evidence","doi":"10.1101/2022.12.22.521159","europe_pmc_metadata":{"abstractText":"Colorectal cancer (CRC) progression is characterised by a remarkable increase in plasticity and cellular heterogeneity 1,2 . The ability of cells to shift states and adopt mixed lineage potential exacerbates during metastasis and associates with poor patient survival 3 . How these atypical differentiated states emerge and drive cancer progression however has remained unclear. Here, we investigate this issue for BRAF-mutant CRC that commonly arise via the serrated pathway 4 and are linked to poor prognosis via incompletely understood progression steps. Using patient-derived organoids, gene editing and murine tumour models, we show that mutations in RNF43, a regulator of WNT receptor abundance 5 , endow BRAF-mutant CRC with metastatic capacity by driving a non-dividing tumour-intrinsic niche cell (TINC) state that provides growth factor self-sufficiency to the cancer tissue. TINCs are enriched in RNF43 -mutant, mucinous and metastatic samples of human CRC, and ablation of TINCs lead to re-acquired external growth factor dependency during CRC organoid outgrowth. 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The ability of cells to shift states and adopt mixed lineage potential exacerbates during metastasis and associates with poor patient survival. How these atypical differentiated states emerge and drive cancer progression however has remained unclear. Here, we investigate this issue for BRAF-mutant CRC that commonly arise via the serrated pathway and are linked to poor prognosis via incompletely understood progression steps. Using patient-derived organoids, gene editing and murine tumour models, we show that mutations in RNF43, a regulator of WNT receptor abundance, endow BRAF-mutant CRC with metastatic capacity by driving a non-dividing tumour-intrinsic niche cell (TINC) state that provides growth factor self-sufficiency to the cancer tissue. TINCs are enriched in RNF43-mutant, mucinous and metastatic samples of human CRC, and ablation of TINCs lead to re-acquired external growth factor dependency during CRC organoid outgrowth. 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M.","category":"cancer biology","date":"2022-12-23","doi":"10.1101/2022.12.22.521159","jatsxml":"https://www.biorxiv.org/content/early/2022/12/23/2022.12.22.521159.source.xml","license":"cc_by_nc_nd","published":"NA","server":"bioRxiv","title":"RNF43 mutations facilitate mucinous colorectal cancer metastasis via formation of a tumour-intrinsic niche","type":"new results","version":"1"},{"abstract":"Colorectal cancer (CRC) progression is characterised by a remarkable increase in plasticity and cellular heterogeneity. The ability of cells to shift states and adopt mixed lineage potential exacerbates during metastasis and associates with poor patient survival. How these atypical differentiated states emerge and drive cancer progression however has remained unclear. Here, we investigate this issue for BRAF-mutant CRC that commonly arise via the serrated pathway and are linked to poor prognosis via incompletely understood progression steps. Using patient-derived organoids, gene editing and murine tumour models, we show that mutations in RNF43, a regulator of WNT receptor abundance, endow BRAF-mutant CRC with metastatic capacity by driving a non-dividing tumour-intrinsic niche cell (TINC) state that provides growth factor self-sufficiency to the cancer tissue. TINCs are enriched in RNF43-mutant, mucinous and metastatic samples of human CRC, and ablation of TINCs lead to re-acquired external growth factor dependency during CRC organoid outgrowth. Together, our findings uncover a mechanism by which tumours leverage cellular plasticity to mediate self-organised stem- and niche-cell interactions. Our results argue that formation of a tumour-intrinsic niche is a prerequisite for BRAF-mutant CRC seeding to distant organs and that interference with niche formation may help avoid metastatic relapse.","author_corresponding":"Madelon M. Maurice","author_corresponding_institution":"Oncode Institute and Centre for Molecular Medicine, UMC Utrecht, the Netherlands","authors":"Bugter, J. M.; El Bouazzaoui, L.; Kucukkose, E.; Hong, Y.; Sprangers, J.; Jordens, I.; Fenderico, N.; Gonzalez, D. M.; van Boxtel, R.; Suijkerbuijk, S. J. E.; Tejpar, S.; Snippert, H. J. G.; Kranenburg, O.; Maurice, M. M.","category":"cancer biology","date":"2023-04-15","doi":"10.1101/2022.12.22.521159","jatsxml":"https://www.biorxiv.org/content/early/2023/04/15/2022.12.22.521159.source.xml","license":"cc_by_nc_nd","published":"NA","server":"bioRxiv","title":"RNF43 mutations facilitate colorectal cancer metastasis via formation of a tumour-intrinsic niche","type":"new results","version":"2"},{"abstract":"Colorectal cancer (CRC) progression is characterised by a remarkable increase in plasticity and cellular heterogeneity. The ability of cells to shift states and adopt mixed lineage potential exacerbates during metastasis and associates with poor patient survival. How these atypical differentiated states emerge and drive cancer progression however has remained unclear. Here, we investigate this issue for BRAF-mutant CRC that commonly arise via the serrated pathway and are linked to poor prognosis via incompletely understood progression steps. Using patient-derived organoids, gene editing and murine tumour models, we show that mutations in RNF43, a regulator of WNT receptor abundance, endow BRAF-mutant CRC with metastatic capacity by driving a non-dividing tumour-intrinsic niche cell (TINC) state that provides growth factor self-sufficiency to the cancer tissue. TINCs are enriched in RNF43-mutant, mucinous and metastatic samples of human CRC, and ablation of TINCs lead to re-acquired external growth factor dependency during CRC organoid outgrowth. Together, our findings uncover a mechanism by which tumours leverage cellular plasticity to mediate self-organised stem- and niche-cell interactions. Our results argue that formation of a tumour-intrinsic niche is a prerequisite for BRAF-mutant CRC seeding to distant organs and that interference with niche formation may help avoid metastatic relapse.","author_corresponding":"Madelon M. Maurice","author_corresponding_institution":"Oncode Institute and Centre for Molecular Medicine, UMC Utrecht, the Netherlands","authors":"Bugter, J. M.; El Bouazzaoui, L.; Kucukkose, E.; Mills, M. L.; Hong, Y.; Sprangers, J.; Jordens, I.; Kokkinidi, D.; Plugge, S.; Venhuizen, A.; Bosman, S.; Hageman, J.; Fenderico, N.; Gilroy, K.; Montiel Gonzalez, D.; van Boxtel, R.; Suijkerbuijk, S. J. E.; Tejpar, S.; Campbell, A. D.; Sansom, O. J.; Snippert, H. J. G.; Kranenburg, O.; Maurice, M. M.","category":"cancer biology","date":"2026-08-20","doi":"10.1101/2022.12.22.521159","jatsxml":"https://www.biorxiv.org/content/early/2026/08/20/2022.12.22.521159.source.xml","license":"cc_by_nc_nd","published":"NA","server":"bioRxiv","title":"Mutation-induced phenotypic plasticity drives formation of a pro-metastatic tumour-intrinsic niche","type":"new results","version":"3"}]},"preprint_id":"DOI:10.1101/2022.12.22.521159","query_memberships":[{"discovery_position":9,"query_family":"disease-association","query_id":"Q-BIORXIV-01","query_scope":"core-disease"},{"discovery_position":10,"query_family":"surface-identity","query_id":"Q-BIORXIV-11","query_scope":"core-disease"},{"discovery_position":1,"query_family":"intervention","query_id":"Q-BIORXIV-31","query_scope":"core-disease"}]},{"canonical_url":"https://doi.org/10.1101/2024.02.01.578409","claim_ceiling":"preprint-discovery-evidence","doi":"10.1101/2024.02.01.578409","europe_pmc_metadata":{"abstractText":"Neuroendocrine cells have been implicated in therapeutic resistance and worse overall survival in many cancer types. Mucinous colorectal cancer (mCRC) is uniquely enriched for enteroendocrine cells (EECs), the neuroendocrine cell of the normal colon epithelium, as compared to non-mucinous CRC. Therefore, targeting EEC differentiation may have clinical value in mCRC. Here, single cell multi-omics was used to uncover epigenetic alterations that accompany EEC differentiation, identify STAT3 as a novel regulator of EEC specification, and discover a rare cancer-specific cell type with enteric neuron-like characteristics. Further experiments demonstrated that lysine-specific demethylase 1 (LSD1) and CoREST2 mediate STAT3 demethylation and regulate STAT3 chromatin binding. Knockdown of CoREST2 in an orthotopic xenograft mouse model resulted in decreased primary tumor growth and lung metastases. In culmination, these results provide rationale for new LSD1 inhibitors that target the interaction between LSD1 with STAT3 or CoREST2, which may improve clinical outcomes for patients with mCRC.","authorString":"Ladaika CA, Ghobashi AH, Boulton WC, Miller SA, O’Hagan HM.","bookOrReportDetails":{"publisher":"bioRxiv","yearOfPublication":2024},"doi":"10.1101/2024.02.01.578409","firstIndexDate":"2024-02-07","firstPublicationDate":"2024-02-05","hasEvaluations":"N","id":"PPR801524","pubTypeList":{"pubType":["Preprint"]},"source":"PPR","title":"Single-cell multi-omics reveals insights into differentiation of rare cell types in mucinous colorectal cancer"},"hydration":{"latest_version":{"abstract":"Neuroendocrine cells have been implicated in therapeutic resistance and worse overall survival in many cancer types. Mucinous colorectal cancer (mCRC) is uniquely enriched for enteroendocrine cells (EECs), the neuroendocrine cell of the normal colon epithelium, as compared to non-mucinous CRC. Therefore, targeting EEC differentiation may have clinical value in mCRC. Here, single cell multi-omics was used to uncover epigenetic alterations that accompany EEC differentiation, identify STAT3 as a novel regulator of EEC specification, and discover a rare cancer-specific cell type with enteric neuron-like characteristics. Further experiments demonstrated that lysine-specific demethylase 1 (LSD1) and CoREST2 mediate STAT3 demethylation and regulate STAT3 chromatin binding. Knockdown of CoREST2 in an orthotopic xenograft mouse model resulted in decreased primary tumor growth and lung metastases. In culmination, these results provide rationale for new LSD1 inhibitors that target the interaction between LSD1 with STAT3 or CoREST2, which may improve clinical outcomes for patients with mCRC.","author_corresponding":"Heather M O'Hagan","author_corresponding_institution":"Indiana University School of Medicine","authors":"Ladaika, C. A.; Ghobashi, A. H.; Boulton, W. C.; Miller, S. A.; O'Hagan, H. M.","category":"cancer biology","date":"2024-02-05","doi":"10.1101/2024.02.01.578409","jatsxml":"https://www.biorxiv.org/content/early/2024/02/05/2024.02.01.578409.source.xml","license":"cc_no","published":"NA","server":"bioRxiv","title":"Single-cell multi-omics reveals insights into differentiation of rare cell types in mucinous colorectal cancer","type":"new results","version":"1"},"publication_links":[],"server":"biorxiv","source_identity_state":"europe-pmc-explicit-biorxiv","source_refs":[{"operation":"details","raw_snapshot":{"bytes":1797,"format":"json","sha256":"8e7fed63c00c6d6f351191941dffd444032d9bf83c99d7b4aaeabec1c19d8f19","storage":"external-artifact-root"},"result_count":1,"server":"biorxiv","status":"complete"},{"operation":"pubs","raw_snapshot":{"bytes":122,"format":"json","sha256":"1dca0f3e1ea71752045116116268aadc693878519e3896bc6c2f0990acdbe150","storage":"external-artifact-root"},"result_count":0,"server":"biorxiv","status":"complete"}],"versions":[{"abstract":"Neuroendocrine cells have been implicated in therapeutic resistance and worse overall survival in many cancer types. Mucinous colorectal cancer (mCRC) is uniquely enriched for enteroendocrine cells (EECs), the neuroendocrine cell of the normal colon epithelium, as compared to non-mucinous CRC. Therefore, targeting EEC differentiation may have clinical value in mCRC. Here, single cell multi-omics was used to uncover epigenetic alterations that accompany EEC differentiation, identify STAT3 as a novel regulator of EEC specification, and discover a rare cancer-specific cell type with enteric neuron-like characteristics. Further experiments demonstrated that lysine-specific demethylase 1 (LSD1) and CoREST2 mediate STAT3 demethylation and regulate STAT3 chromatin binding. Knockdown of CoREST2 in an orthotopic xenograft mouse model resulted in decreased primary tumor growth and lung metastases. In culmination, these results provide rationale for new LSD1 inhibitors that target the interaction between LSD1 with STAT3 or CoREST2, which may improve clinical outcomes for patients with mCRC.","author_corresponding":"Heather M O'Hagan","author_corresponding_institution":"Indiana University School of Medicine","authors":"Ladaika, C. A.; Ghobashi, A. H.; Boulton, W. C.; Miller, S. A.; O'Hagan, H. M.","category":"cancer biology","date":"2024-02-05","doi":"10.1101/2024.02.01.578409","jatsxml":"https://www.biorxiv.org/content/early/2024/02/05/2024.02.01.578409.source.xml","license":"cc_no","published":"NA","server":"bioRxiv","title":"Single-cell multi-omics reveals insights into differentiation of rare cell types in mucinous colorectal cancer","type":"new results","version":"1"}]},"preprint_id":"DOI:10.1101/2024.02.01.578409","query_memberships":[{"discovery_position":3,"query_family":"disease-association","query_id":"Q-BIORXIV-01","query_scope":"core-disease"},{"discovery_position":5,"query_family":"surface-identity","query_id":"Q-BIORXIV-11","query_scope":"core-disease"}]},{"canonical_url":"https://doi.org/10.1101/2024.09.16.613285","claim_ceiling":"preprint-discovery-evidence","doi":"10.1101/2024.09.16.613285","europe_pmc_metadata":{"abstractText":"Many cancers are characterized by altered mucin expression and glycosylation, although the mechanistic relationship between tumor glycosylation and disease progression is not well-defined. Herein, our goal was to map specific mucin glycoforms in diseased tissue, enabling correlation of the tumor glycan profile with malignant features. To this end, we developed a workflow implementing on-tissue digestion with mucinase StcE, followed by matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI) and liquid chromatography coupled to mass spectrometry (LC-MS). To optimize our workflow, we analyzed four different mucinous carcinomas derived from colon, esophageal, and salivary gland tissue. Using this technique, we deduced the spatial distribution of StcE-generated O-glycopeptides within mucinous tumors using MALDI-IMS. Subsequent LC-MS analyses revealed the identity of different species detected in imaging experiments, in addition to comprehensively characterizing the mucinome and proteome of each tissue. Our coupled MS approach unveiled a striking mucin 2 (MUC2) expression pattern in two colorectal mucinous adenocarcinomas, in which different glycoforms clearly stratified regions within the tumor. Notably, our LC-MS experiments obtained near-complete sequence coverage over the mucin domains of MUC2, enabling glycoproteomic mapping of this canonical mucin in unprecedented depth. MUC2 glycosylation was dominated by the T and Tn antigens, with surprisingly little sialylation detected. However, O-glycans containing mono- and di-O-acetylated sialic acid were detected in low abundance. Finally, we obtained spectral evidence for an endogenous O-acetylated GalNAc, an O-glycan structure not previously reported in the literature. Overall, this proof-of-concept work underscores the potential of this technique to generate new research avenues in oncology and beyond. Significance Statement
Aberrant mucin expression and glycosylation are hallmarks of cancer, but how these changes promote malignant processes are not well understood. Solid tumors are highly heterogeneous in their cellular and molecular composition, and many advanced spatial techniques have emerged in recent years to study the tumor microenvironment (TME) for better understanding disease progression. Spatially resolved glycoprotein analyses typically detect either the protein or glycan components, but not both. We developed a workflow using a dual mass spectrometry approach to map the location of intact glycopeptides in mucinous tumors, enabled by on-tissue digestion with the mucin-specific protease StcE. Future applications of this method on larger patient cohorts will enhance our understanding of glycans in malignancy, identify disease biomarkers, and define therapeutic targets.","authorString":"Lowery SC, Tran IP, Grimsley G, Stubler R, Mahoney KE, Lucas TM, Charkoftaki G, Santos-Neto A, Varki N, Vasiliou V, Drake RR, Malaker SA.","bookOrReportDetails":{"publisher":"bioRxiv","yearOfPublication":2024},"doi":"10.1101/2024.09.16.613285","firstIndexDate":"2024-09-21","firstPublicationDate":"2024-09-20","hasEvaluations":"N","id":"PPR912172","pubTypeList":{"pubType":["Preprint"]},"source":"PPR","title":"Glycosite Mapping and in situ Mass Spectrometry Imaging of MUC2 Glycopeptides via On-slide Digestion with Mucinase StcE"},"hydration":{"latest_version":{"abstract":"Many cancers are characterized by altered mucin expression and glycosylation, although the mechanistic relationship between tumor glycosylation and disease progression is not well-defined. Herein, our goal was to map specific mucin glycoforms in diseased tissue, enabling correlation of the tumor glycan profile with malignant features. To this end, we developed a workflow implementing on-tissue digestion with mucinase StcE, followed by matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI) and liquid chromatography coupled to mass spectrometry (LC-MS). To optimize our workflow, we analyzed four different mucinous carcinomas derived from colon, esophageal, and salivary gland tissue.\n\nUsing this technique, we deduced the spatial distribution of StcE-generated O-glycopeptides within mucinous tumors using MALDI-IMS. Subsequent LC-MS analyses revealed the identity of different species detected in imaging experiments, in addition to comprehensively characterizing the mucinome and proteome of each tissue. Our coupled MS approach unveiled a striking mucin 2 (MUC2) expression pattern in two colorectal mucinous adenocarcinomas, in which different glycoforms clearly stratified regions within the tumor. Notably, our LC-MS experiments obtained near-complete sequence coverage over the mucin domains of MUC2, enabling glycoproteomic mapping of this canonical mucin in unprecedented depth. MUC2 glycosylation was dominated by the T and Tn antigens, with surprisingly little sialylation detected. However, O-glycans containing mono- and di-O-acetylated sialic acid were detected in low abundance. Finally, we obtained spectral evidence for an endogenous O-acetylated GalNAc, an O-glycan structure not previously reported in the literature. Overall, this proof-of-concept work underscores the potential of this technique to generate new research avenues in oncology and beyond.\n\nSignificance StatementAberrant mucin expression and glycosylation are hallmarks of cancer, but how these changes promote malignant processes are not well understood. Solid tumors are highly heterogeneous in their cellular and molecular composition, and many advanced spatial techniques have emerged in recent years to study the tumor microenvironment (TME) for better understanding disease progression. Spatially resolved glycoprotein analyses typically detect either the protein or glycan components, but not both. We developed a workflow using a dual mass spectrometry approach to map the location of intact glycopeptides in mucinous tumors, enabled by on-tissue digestion with the mucin-specific protease StcE. Future applications of this method on larger patient cohorts will enhance our understanding of glycans in malignancy, identify disease biomarkers, and define therapeutic targets.","author_corresponding":"Stacy A Malaker","author_corresponding_institution":"Yale University","authors":"Lowery, S. C.; Tran, I. P.; Grimsley, G.; Stubler, R.; Mahoney, K. E.; Lucas, T. M.; Charkoftaki, G.; Santos-Neto, A.; Varki, N.; Vasiliou, V.; Drake, R. R.; Malaker, S. A.","category":"cancer biology","date":"2024-09-20","doi":"10.1101/2024.09.16.613285","jatsxml":"https://www.biorxiv.org/content/early/2024/09/20/2024.09.16.613285.source.xml","license":"cc_by_nc_nd","published":"NA","server":"bioRxiv","title":"Glycosite Mapping and in situ Mass Spectrometry Imaging of MUC2 Glycopeptides via On-slide Digestion with Mucinase StcE","type":"new results","version":"1"},"publication_links":[],"server":"biorxiv","source_identity_state":"europe-pmc-explicit-biorxiv","source_refs":[{"operation":"details","raw_snapshot":{"bytes":3590,"format":"json","sha256":"2876f9bdc524b9ef8631781e3b2e4753d59aed15714524f62eb46027613a8a4b","storage":"external-artifact-root"},"result_count":1,"server":"biorxiv","status":"complete"},{"operation":"pubs","raw_snapshot":{"bytes":122,"format":"json","sha256":"2ec23b6333191504c62e1d57fad2dd7bf1e4043209225755bab35ee40695c946","storage":"external-artifact-root"},"result_count":0,"server":"biorxiv","status":"complete"}],"versions":[{"abstract":"Many cancers are characterized by altered mucin expression and glycosylation, although the mechanistic relationship between tumor glycosylation and disease progression is not well-defined. Herein, our goal was to map specific mucin glycoforms in diseased tissue, enabling correlation of the tumor glycan profile with malignant features. To this end, we developed a workflow implementing on-tissue digestion with mucinase StcE, followed by matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI) and liquid chromatography coupled to mass spectrometry (LC-MS). To optimize our workflow, we analyzed four different mucinous carcinomas derived from colon, esophageal, and salivary gland tissue.\n\nUsing this technique, we deduced the spatial distribution of StcE-generated O-glycopeptides within mucinous tumors using MALDI-IMS. Subsequent LC-MS analyses revealed the identity of different species detected in imaging experiments, in addition to comprehensively characterizing the mucinome and proteome of each tissue. Our coupled MS approach unveiled a striking mucin 2 (MUC2) expression pattern in two colorectal mucinous adenocarcinomas, in which different glycoforms clearly stratified regions within the tumor. Notably, our LC-MS experiments obtained near-complete sequence coverage over the mucin domains of MUC2, enabling glycoproteomic mapping of this canonical mucin in unprecedented depth. MUC2 glycosylation was dominated by the T and Tn antigens, with surprisingly little sialylation detected. However, O-glycans containing mono- and di-O-acetylated sialic acid were detected in low abundance. Finally, we obtained spectral evidence for an endogenous O-acetylated GalNAc, an O-glycan structure not previously reported in the literature. Overall, this proof-of-concept work underscores the potential of this technique to generate new research avenues in oncology and beyond.\n\nSignificance StatementAberrant mucin expression and glycosylation are hallmarks of cancer, but how these changes promote malignant processes are not well understood. Solid tumors are highly heterogeneous in their cellular and molecular composition, and many advanced spatial techniques have emerged in recent years to study the tumor microenvironment (TME) for better understanding disease progression. Spatially resolved glycoprotein analyses typically detect either the protein or glycan components, but not both. We developed a workflow using a dual mass spectrometry approach to map the location of intact glycopeptides in mucinous tumors, enabled by on-tissue digestion with the mucin-specific protease StcE. Future applications of this method on larger patient cohorts will enhance our understanding of glycans in malignancy, identify disease biomarkers, and define therapeutic targets.","author_corresponding":"Stacy A Malaker","author_corresponding_institution":"Yale University","authors":"Lowery, S. C.; Tran, I. P.; Grimsley, G.; Stubler, R.; Mahoney, K. E.; Lucas, T. M.; Charkoftaki, G.; Santos-Neto, A.; Varki, N.; Vasiliou, V.; Drake, R. R.; Malaker, S. A.","category":"cancer biology","date":"2024-09-20","doi":"10.1101/2024.09.16.613285","jatsxml":"https://www.biorxiv.org/content/early/2024/09/20/2024.09.16.613285.source.xml","license":"cc_by_nc_nd","published":"NA","server":"bioRxiv","title":"Glycosite Mapping and in situ Mass Spectrometry Imaging of MUC2 Glycopeptides via On-slide Digestion with Mucinase StcE","type":"new results","version":"1"}]},"preprint_id":"DOI:10.1101/2024.09.16.613285","query_memberships":[{"discovery_position":5,"query_family":"disease-association","query_id":"Q-BIORXIV-01","query_scope":"core-disease"}]},{"canonical_url":"https://doi.org/10.1101/2024.11.20.624298","claim_ceiling":"preprint-discovery-evidence","doi":"10.1101/2024.11.20.624298","europe_pmc_metadata":{"abstractText":"Mucinous colorectal carcinoma (MUC CRC) dissemination into the tumor stroma and metastasis to multiple organs, including the peritoneum, is associated with poor prognosis. Disseminating MUC CRCs exhibit either a conventional ‘apical-in’ or an inverted ‘apical-out’ polarity phenotype that influence patient outcome. Identifying the mechanisms controlling MUC CRC polarity is critical to understand disease progression. Here, we analyze patient-derived MUC CRC xenografts, with apical-in or apical-out polarity, ex vivo or within collagen gels to mimic the peritumoral stroma. Single-cell analyses reveal α2β1-integrin as a key collagen-binding receptor in these models. Collagen–α2β1-integrin interaction activates Src and ERK/MAPK signaling and upregulates the expression of SorLA, an endosomal sorting receptor. SorLA supports apical-in polarity and carcinoma-stroma interactions by promoting integrin recycling to the plasma membrane and HER2/HER3 expression through a positive feedback mechanism. Accordingly, we observe positive correlation between HER2, HER3 and SorLA in patient samples with the highest HER2 expression in apical-in-presenting tissues. Treatment of tumor spheres with clinically relevant HER2/HER3-targeting antibodies reverts sphere polarity and impedes collagen remodeling and adhesion to mouse peritoneum. This SorLA—integrin—HER2/HER3 signaling axis may represent a basis for MUC CRC-patient stratification and shed light on other carcinomas with similar apical-out phenotypes.","authorString":"Pasquier N, Isomursu A, Hamidi H, Mathieu JR, Härkönen J, Follain G, Desterke C, Fusilier Z, Solis J, Belaya I, Kankaanpää P, Barresi V, Cartry J, Bedja S, Jaulin F, Ivaska J.","bookOrReportDetails":{"publisher":"bioRxiv","yearOfPublication":2024},"doi":"10.1101/2024.11.20.624298","firstIndexDate":"2024-11-23","firstPublicationDate":"2024-11-21","hasEvaluations":"N","id":"PPR944052","pubTypeList":{"pubType":["Preprint"]},"source":"PPR","title":"Signaling downstream of tumor-stroma interaction regulates mucinous colorectal adenocarcinoma apicobasal polarity"},"hydration":{"latest_version":{"abstract":"Mucinous colorectal carcinoma (MUC CRC) dissemination into the tumor stroma and metastasis to multiple organs, including the peritoneum, is associated with poor prognosis. Disseminating MUC CRCs exhibit either a conventional apical-in or an inverted apical-out polarity phenotype that influence patient outcome. Identifying the mechanisms controlling MUC CRC polarity is critical to understand disease progression. Here, we analyze patient-derived MUC CRC xenografts, with apical-in or apical-out polarity, ex vivo or within collagen gels to mimic the peritumoral stroma. Single-cell analyses reveal 2{beta}1-integrin as a key collagen-binding receptor in these models. Collagen-2{beta}1-integrin interaction activates Src and ERK/MAPK signaling and upregulates the expression of SorLA, an endosomal sorting receptor. SorLA supports apical-in polarity and carcinoma-stroma interactions by promoting integrin recycling to the plasma membrane and HER2/HER3 expression through a positive feedback mechanism. Accordingly, we observe positive correlation between HER2, HER3 and SorLA in patient samples with the highest HER2 expression in apical-in-presenting tissues. Treatment of tumor spheres with clinically relevant HER2/HER3-targeting antibodies reverts sphere polarity and impedes collagen remodeling and adhesion to mouse peritoneum. This SorLA--integrin--HER2/HER3 signaling axis may represent a basis for MUC CRC-patient stratification and shed light on other carcinomas with similar apical-out phenotypes.","author_corresponding":"Johanna Ivaska","author_corresponding_institution":"University of Turku","authors":"Pasquier, N.; Isomursu, A.; Hamidi, H.; Mathieu, J. R. R.; Härkönen, J.; Follain, G.; Desterke, C.; Fusilier, Z.; Solis, J.; Belaya, I.; Kankaanpää, P.; Barresi, V.; Cartry, J.; Bedja, S.; Jaulin, F.; Ivaska, J.","category":"cancer biology","date":"2024-11-21","doi":"10.1101/2024.11.20.624298","jatsxml":"https://www.biorxiv.org/content/early/2024/11/21/2024.11.20.624298.source.xml","license":"cc_by_nc_nd","published":"10.1038/s41467-026-75127-0","server":"bioRxiv","title":"Signaling downstream of tumor-stroma interaction regulates mucinous colorectal adenocarcinoma apicobasal polarity","type":"new results","version":"1"},"publication_links":[{"preprint_doi":"10.1101/2024.11.20.624298","published_doi":"10.1038/s41467-026-75127-0"}],"server":"biorxiv","source_identity_state":"europe-pmc-explicit-biorxiv","source_refs":[{"operation":"details","raw_snapshot":{"bytes":2388,"format":"json","sha256":"9bb59179b022bd9eb3bfd5a99ff36c366caca045d62b336b25a7fde4d2830f74","storage":"external-artifact-root"},"result_count":1,"server":"biorxiv","status":"complete"},{"operation":"pubs","raw_snapshot":{"bytes":2361,"format":"json","sha256":"d17a5d0f08dc219419da7ad59168d655ab099389fe324fbab7af35bbc25bfbe1","storage":"external-artifact-root"},"result_count":1,"server":"biorxiv","status":"complete"}],"versions":[{"abstract":"Mucinous colorectal carcinoma (MUC CRC) dissemination into the tumor stroma and metastasis to multiple organs, including the peritoneum, is associated with poor prognosis. Disseminating MUC CRCs exhibit either a conventional apical-in or an inverted apical-out polarity phenotype that influence patient outcome. Identifying the mechanisms controlling MUC CRC polarity is critical to understand disease progression. Here, we analyze patient-derived MUC CRC xenografts, with apical-in or apical-out polarity, ex vivo or within collagen gels to mimic the peritumoral stroma. Single-cell analyses reveal 2{beta}1-integrin as a key collagen-binding receptor in these models. Collagen-2{beta}1-integrin interaction activates Src and ERK/MAPK signaling and upregulates the expression of SorLA, an endosomal sorting receptor. SorLA supports apical-in polarity and carcinoma-stroma interactions by promoting integrin recycling to the plasma membrane and HER2/HER3 expression through a positive feedback mechanism. Accordingly, we observe positive correlation between HER2, HER3 and SorLA in patient samples with the highest HER2 expression in apical-in-presenting tissues. Treatment of tumor spheres with clinically relevant HER2/HER3-targeting antibodies reverts sphere polarity and impedes collagen remodeling and adhesion to mouse peritoneum. This SorLA--integrin--HER2/HER3 signaling axis may represent a basis for MUC CRC-patient stratification and shed light on other carcinomas with similar apical-out phenotypes.","author_corresponding":"Johanna Ivaska","author_corresponding_institution":"University of Turku","authors":"Pasquier, N.; Isomursu, A.; Hamidi, H.; Mathieu, J. R. R.; Härkönen, J.; Follain, G.; Desterke, C.; Fusilier, Z.; Solis, J.; Belaya, I.; Kankaanpää, P.; Barresi, V.; Cartry, J.; Bedja, S.; Jaulin, F.; Ivaska, J.","category":"cancer biology","date":"2024-11-21","doi":"10.1101/2024.11.20.624298","jatsxml":"https://www.biorxiv.org/content/early/2024/11/21/2024.11.20.624298.source.xml","license":"cc_by_nc_nd","published":"10.1038/s41467-026-75127-0","server":"bioRxiv","title":"Signaling downstream of tumor-stroma interaction regulates mucinous colorectal adenocarcinoma apicobasal polarity","type":"new results","version":"1"}]},"preprint_id":"DOI:10.1101/2024.11.20.624298","query_memberships":[{"discovery_position":2,"query_family":"disease-association","query_id":"Q-BIORXIV-01","query_scope":"core-disease"},{"discovery_position":3,"query_family":"surface-identity","query_id":"Q-BIORXIV-11","query_scope":"core-disease"}]},{"canonical_url":"https://doi.org/10.1101/2025.04.21.25326138","claim_ceiling":"preprint-discovery-evidence","doi":"10.1101/2025.04.21.25326138","europe_pmc_metadata":{"abstractText":"Background
Early-onset bowel cancer incidence (age <50 years) has increased worldwide and is highest in Australia, but how this varies across histology and anatomical site remains unclear. We aimed to investigate appendiceal, proximal colon, distal colon, rectal, and anal cancer incidence trends by age and histology in Australia. Methods
Cancer incidence rate data were obtained from all Australian cancer registries (1990-2020 period). Birth cohort-specific incidence rate ratios (IRRs) and annual percentage change in rates were estimated using age-period-cohort modelling and joinpoint regression. Findings
After excluding neuroendocrine neoplasms, early-onset cancer incidence rose 5-9% annually, yielding 5,341 excess cases (2 per 100,000 person-years; 12% appendix, 45% colon, 36% rectum, 7% anus; 20-214% relative increase). Trends varied by site, period, and age: appendiceal cancer rose from 1990-2020 in 30-49-year-olds; colorectal cancers rose from around 1990-2010 in 20-29-year-olds and from 2010-2020 in 30-39-year-olds; anal cancer rose from 1990-2009 in 40-49-year-olds. Across all sites, IRRs increased with successive birth cohorts since 1960. Notably, adenocarcinoma incidence in the 1990s versus 1950s birth cohort was 2-3-fold for colorectum and 7-fold for appendix. The greatest subtype-specific increases occurred for appendiceal mucinous adenocarcinoma, colorectal non-mucinous adenocarcinoma, and anal squamous cell carcinoma. Only later-onset (age ≥50) colorectal and anal adenocarcinoma rates declined. Appendiceal tumours, neuroendocrine neoplasms (all sites), anorectal squamous cell carcinomas, and colon signet ring cell carcinomas rose across early-onset and later-onset strata. Interpretation
Appendiceal, colorectal, and anal cancer incidence is rising in Australia with variation across age and histology, underscoring the need to identify factors driving these trends. Funding
ALM is supported by an Australian Government Research Training Program Scholarship, Rowden White Scholarship, and WP Greene Scholarship. DDB is supported by a National Health and Medical Research Council of Australia (NHMRC) Investigator grant (GNT1194896), a University of Melbourne Dame Kate Campbell Fellowship, and by funding awarded to The Colon Cancer Family Registry (CCFR, www.coloncfr.org ) from the National Cancer Institute (NCI), National Institutes of Health (NIH) [award U01 CA167551]. MAJ is supported by an NHMRC Investigator grant (GNT1195099), a University of Melbourne Dame Kate Campbell Fellowship, and by funding awarded to the CCFR from NCI, NIH [award U01 CA167551].","authorString":"Meyers AL, Dowty JG, Mahmood K, Macrae FA, Rosty C, Buchanan DD, Jenkins MA.","bookOrReportDetails":{"publisher":"medRxiv","yearOfPublication":2025},"doi":"10.1101/2025.04.21.25326138","firstIndexDate":"2025-04-26","firstPublicationDate":"2025-04-24","hasEvaluations":"N","id":"PPR1009623","pubTypeList":{"pubType":["Preprint"]},"source":"PPR","title":"Age-specific trends in colorectal, appendiceal, and anal tumour incidence by histological subtype in Australia from 1990 to 2020: a population-based time-series analysis"},"hydration":{"latest_version":{"abstract":"BackgroundEarly-onset bowel cancer incidence (age <50 years) has increased worldwide and is highest in Australia, but how this varies across histology and anatomical site remains unclear. We aimed to investigate appendiceal, proximal colon, distal colon, rectal, and anal cancer incidence trends by age and histology in Australia.\n\nMethodsCancer incidence rate data were obtained from all Australian cancer registries (1990-2020 period). Birth cohort-specific incidence rate ratios (IRRs) and annual percentage change in rates were estimated using age-period-cohort modelling and joinpoint regression.\n\nFindingsAfter excluding neuroendocrine neoplasms, early-onset cancer incidence rose 5-9% annually, yielding 5,341 excess cases (2 per 100,000 person-years; 12% appendix, 45% colon, 36% rectum, 7% anus; 20-214% relative increase). Trends varied by site, period, and age: appendiceal cancer rose from 1990-2020 in 30-49-year-olds; colorectal cancers rose from around 1990-2010 in 20-29-year-olds and from 2010-2020 in 30-39-year-olds; anal cancer rose from 1990-2009 in 40-49-year-olds. Across all sites, IRRs increased with successive birth cohorts since 1960. Notably, adenocarcinoma incidence in the 1990s versus 1950s birth cohort was 2-3-fold for colorectum and 7-fold for appendix. The greatest subtype-specific increases occurred for appendiceal mucinous adenocarcinoma, colorectal non-mucinous adenocarcinoma, and anal squamous cell carcinoma. Only later-onset (age [≥]50) colorectal and anal adenocarcinoma rates declined. Appendiceal tumours, neuroendocrine neoplasms (all sites), anorectal squamous cell carcinomas, and colon signet ring cell carcinomas rose across early-onset and later-onset strata.\n\nInterpretationAppendiceal, colorectal, and anal cancer incidence is rising in Australia with variation across age and histology, underscoring the need to identify factors driving these trends.\n\nFundingALM is supported by an Australian Government Research Training Program Scholarship, Rowden White Scholarship, and WP Greene Scholarship. DDB is supported by a National Health and Medical Research Council of Australia (NHMRC) Investigator grant (GNT1194896), a University of Melbourne Dame Kate Campbell Fellowship, and by funding awarded to The Colon Cancer Family Registry (CCFR, www.coloncfr.org) from the National Cancer Institute (NCI), National Institutes of Health (NIH) [award U01 CA167551]. MAJ is supported by an NHMRC Investigator grant (GNT1195099), a University of Melbourne Dame Kate Campbell Fellowship, and by funding awarded to the CCFR from NCI, NIH [award U01 CA167551].","author_corresponding":"Aaron L Meyers","author_corresponding_institution":"Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, Victoria, Australia.","authors":"Meyers, A. L.; Dowty, J. G.; Mahmood, K.; Macrae, F. A.; Rosty, C.; Buchanan, D. D.; Jenkins, M. 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We aimed to investigate appendiceal, proximal colon, distal colon, rectal, and anal cancer incidence trends by age and histology in Australia.\n\nMethodsCancer incidence rate data were obtained from all Australian cancer registries (1990-2020 period). Birth cohort-specific incidence rate ratios (IRRs) and annual percentage change in rates were estimated using age-period-cohort modelling and joinpoint regression.\n\nFindingsAfter excluding neuroendocrine neoplasms, early-onset cancer incidence rose 5-9% annually, yielding 5,341 excess cases (2 per 100,000 person-years; 12% appendix, 45% colon, 36% rectum, 7% anus; 20-214% relative increase). Trends varied by site, period, and age: appendiceal cancer rose from 1990-2020 in 30-49-year-olds; colorectal cancers rose from around 1990-2010 in 20-29-year-olds and from 2010-2020 in 30-39-year-olds; anal cancer rose from 1990-2009 in 40-49-year-olds. Across all sites, IRRs increased with successive birth cohorts since 1960. Notably, adenocarcinoma incidence in the 1990s versus 1950s birth cohort was 2-3-fold for colorectum and 7-fold for appendix. The greatest subtype-specific increases occurred for appendiceal mucinous adenocarcinoma, colorectal non-mucinous adenocarcinoma, and anal squamous cell carcinoma. Only later-onset (age [≥]50) colorectal and anal adenocarcinoma rates declined. Appendiceal tumours, neuroendocrine neoplasms (all sites), anorectal squamous cell carcinomas, and colon signet ring cell carcinomas rose across early-onset and later-onset strata.\n\nInterpretationAppendiceal, colorectal, and anal cancer incidence is rising in Australia with variation across age and histology, underscoring the need to identify factors driving these trends.\n\nFundingALM is supported by an Australian Government Research Training Program Scholarship, Rowden White Scholarship, and WP Greene Scholarship. DDB is supported by a National Health and Medical Research Council of Australia (NHMRC) Investigator grant (GNT1194896), a University of Melbourne Dame Kate Campbell Fellowship, and by funding awarded to The Colon Cancer Family Registry (CCFR, www.coloncfr.org) from the National Cancer Institute (NCI), National Institutes of Health (NIH) [award U01 CA167551]. MAJ is supported by an NHMRC Investigator grant (GNT1195099), a University of Melbourne Dame Kate Campbell Fellowship, and by funding awarded to the CCFR from NCI, NIH [award U01 CA167551].","author_corresponding":"Aaron L Meyers","author_corresponding_institution":"Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, Victoria, Australia.","authors":"Meyers, A. L.; Dowty, J. G.; Mahmood, K.; Macrae, F. A.; Rosty, C.; Buchanan, D. D.; Jenkins, M. 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/evidence=\"ECO:0000269|PubMed:10373415, ECO:0000269|PubMed:11341784\"","subcellular_location":"SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:11118479, ECO:0000269|PubMed:12832415, ECO:0000269|PubMed:12939402, ECO:0000269|PubMed:15471854, ECO:0000269|PubMed:15972891, ECO:0000269|PubMed:16507569, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:17545600}; Single-pass type I membrane protein {ECO:0000269|PubMed:11118479, ECO:0000269|PubMed:12832415, ECO:0000269|PubMed:12939402, ECO:0000269|PubMed:15471854, ECO:0000269|PubMed:15972891, ECO:0000269|PubMed:16507569, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:17545600}. Note=Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis, internalized and recycled to the cell membrane. Located to microvilli and to the tips of long filopodial protusions.; SUBCELLULAR LOCATION: [Isoform 5]: Secreted.; SUBCELLULAR LOCATION: [Isoform Y]: Secreted.; SUBCELLULAR LOCATION: [Isoform 9]: Secreted.; SUBCELLULAR LOCATION: [Mucin-1 subunit beta]: Cell membrane. Cytoplasm. Nucleus. Note=On EGF and PDGFRB stimulation, transported to the nucleus through interaction with CTNNB1, a process which is stimulated by phosphorylation. On HRG stimulation, colocalizes with JUP/gamma-catenin at the nucleus.","topological_domain":"TOPO_DOM 24..1158; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 1182..1255; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 1159..1181; /note=\"Helical\"; /evidence=\"ECO:0000255\""},"signal_peptides":[{"description":null,"end":23,"evidence":"ECO:0000269|PubMed:10373415, ECO:0000269|PubMed:11341784","source_location":"SIGNAL 1..23; /evidence=\"ECO:0000269|PubMed:10373415, ECO:0000269|PubMed:11341784\"","start":1}],"state":"available","topological_domains":[{"description":"Extracellular","end":1158,"evidence":"ECO:0000255","source_location":"TOPO_DOM 24..1158; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":24},{"description":"Cytoplasmic","end":1255,"evidence":"ECO:0000255","source_location":"TOPO_DOM 1182..1255; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":1182}],"transmembrane_segments":[{"description":"Helical","end":1181,"evidence":"ECO:0000255","source_location":"TRANSMEM 1159..1181; 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Endoplasmic reticulum membrane {ECO:0000269|PubMed:27153536}; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Endosome {ECO:0000269|PubMed:17182860, ECO:0000269|PubMed:27153536}. Endosome membrane. Nucleus {ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:20551055, ECO:0000269|PubMed:20674546}. Note=In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER (PubMed:17909029, PubMed:20674546). Endocytosed upon activation by ligand (PubMed:17182860, PubMed:17909029, PubMed:27153536, PubMed:2790960). 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Cell membrane {ECO:0000269|PubMed:23704991}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:20375010}. 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Multi-pass membrane protein {ECO:0000255}. Melanosome {ECO:0000269|PubMed:17081065}. Photoreceptor inner segment {ECO:0000250|UniProtKB:P17809}. Note=Localizes primarily at the cell surface (PubMed:18245775, PubMed:19449892, PubMed:23219802, PubMed:24847886, PubMed:25982116). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). {ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:18245775, ECO:0000269|PubMed:19449892, ECO:0000269|PubMed:23219802, ECO:0000269|PubMed:24847886, ECO:0000269|PubMed:25982116}.","topological_domain":"TOPO_DOM 1..11; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:24847886\"; TOPO_DOM 34..66; /note=\"Extracellular\"; /evidence=\"ECO:0000269|PubMed:24847886\"; TOPO_DOM 88..90; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:24847886\"; TOPO_DOM 113..120; /note=\"Extracellular\"; /evidence=\"ECO:0000269|PubMed:24847886\"; TOPO_DOM 145..155; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:24847886\"; TOPO_DOM 177..185; /note=\"Extracellular\"; /evidence=\"ECO:0000269|PubMed:24847886\"; TOPO_DOM 207..271; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:24847886\"; TOPO_DOM 294..306; /note=\"Extracellular\"; /evidence=\"ECO:0000269|PubMed:24847886\"; TOPO_DOM 329..334; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:24847886\"; TOPO_DOM 356..365; /note=\"Extracellular\"; /evidence=\"ECO:0000269|PubMed:24847886\"; TOPO_DOM 389..401; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:24847886\"; TOPO_DOM 423..429; /note=\"Extracellular\"; /evidence=\"ECO:0000269|PubMed:24847886\"; TOPO_DOM 451..492; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:24847886\"","transmembrane":"TRANSMEM 12..33; /note=\"Helical; Name=1\"; TRANSMEM 67..87; /note=\"Helical; Name=2\"; TRANSMEM 91..112; /note=\"Helical; Name=3\"; TRANSMEM 121..144; /note=\"Helical; Name=4\"; TRANSMEM 156..176; /note=\"Helical; Name=5\"; TRANSMEM 186..206; /note=\"Helical; Name=6\"; TRANSMEM 272..293; /note=\"Helical; Name=7\"; TRANSMEM 307..328; /note=\"Helical; Name=8\"; TRANSMEM 335..355; /note=\"Helical; Name=9\"; TRANSMEM 366..388; /note=\"Helical; Name=10\"; TRANSMEM 402..422; /note=\"Helical; Name=11\"; TRANSMEM 430..450; /note=\"Helical; Name=12\""},"signal_peptides":[],"state":"available","topological_domains":[{"description":"Cytoplasmic","end":11,"evidence":"ECO:0000269|PubMed:24847886","source_location":"TOPO_DOM 1..11; 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/note=\"Extracellular\"; /evidence=\"ECO:0000269|PubMed:24847886\"","start":423},{"description":"Cytoplasmic","end":492,"evidence":"ECO:0000269|PubMed:24847886","source_location":"TOPO_DOM 451..492; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:24847886\"","start":451}],"transmembrane_segments":[{"description":"Helical; Name=1","end":33,"evidence":null,"source_location":"TRANSMEM 12..33; /note=\"Helical; Name=1\"","start":12},{"description":"Helical; Name=2","end":87,"evidence":null,"source_location":"TRANSMEM 67..87; /note=\"Helical; Name=2\"","start":67},{"description":"Helical; Name=3","end":112,"evidence":null,"source_location":"TRANSMEM 91..112; /note=\"Helical; Name=3\"","start":91},{"description":"Helical; Name=4","end":144,"evidence":null,"source_location":"TRANSMEM 121..144; /note=\"Helical; Name=4\"","start":121},{"description":"Helical; Name=5","end":176,"evidence":null,"source_location":"TRANSMEM 156..176; /note=\"Helical; Name=5\"","start":156},{"description":"Helical; 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/evidence=\"ECO:0000269|PubMed:8119947\"","subcellular_location":"SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.","topological_domain":"TOPO_DOM 19..1126; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 1148..1179; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 1127..1147; /note=\"Helical\"; /evidence=\"ECO:0000255\""},"signal_peptides":[{"description":null,"end":18,"evidence":"ECO:0000269|PubMed:8119947","source_location":"SIGNAL 1..18; /evidence=\"ECO:0000269|PubMed:8119947\"","start":1}],"state":"available","topological_domains":[{"description":"Extracellular","end":1126,"evidence":"ECO:0000255","source_location":"TOPO_DOM 19..1126; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":19},{"description":"Cytoplasmic","end":1179,"evidence":"ECO:0000255","source_location":"TOPO_DOM 1148..1179; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":1148}],"transmembrane_segments":[{"description":"Helical","end":1147,"evidence":"ECO:0000255","source_location":"TRANSMEM 1127..1147; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":1127}]},"uniprot_accession":"P38570"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000105976","evidence_rank":23,"extracellular_segments":{"records":[{"basis":"reviewed-uniprot-topological-domain","end":932,"evidence_class":"source-annotated-topology","length":908,"sequence":"ECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSALGAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLDAQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRSAMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGWCHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEFAVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFT","sequence_sha256":"6069a4885da6c3cf4cf37f6bfb3f22e9fc5ce1c79f4477e63f1cba2a8a75c2d1","start":25}],"state":"source-annotated"},"gene_symbol":"MET","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSALGAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLDAQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRSAMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGWCHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEFAVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVDTRPASFWETS","length":1390,"sha256":"cc24e8701a5717fd1fa418174adb3b6cbaeae8a76f78b33a995f44c5bb394056","state":"available"},"source_refs":[{"artifact":{"bytes":11795,"format":"json","sha256":"01bdedbc1ee4289b1b17ddb453a556699e897c7a0d75eb5a83c7fd639154e022","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/P08581"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"P08581","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"structure-a","target_id":"T-ENSG00000105976","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":1390},"entry_name":"MET_HUMAN","gene_names":"MET","lipidation_sites":[],"protein_names":"Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)","raw_fields":{"lipidation":"","signal_peptide":"SIGNAL 1..24; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted.","topological_domain":"TOPO_DOM 25..932; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 956..1390; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 933..955; /note=\"Helical\"; /evidence=\"ECO:0000255\""},"signal_peptides":[{"description":null,"end":24,"evidence":"ECO:0000255","source_location":"SIGNAL 1..24; /evidence=\"ECO:0000255\"","start":1}],"state":"available","topological_domains":[{"description":"Extracellular","end":932,"evidence":"ECO:0000255","source_location":"TOPO_DOM 25..932; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":25},{"description":"Cytoplasmic","end":1390,"evidence":"ECO:0000255","source_location":"TOPO_DOM 956..1390; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":956}],"transmembrane_segments":[{"description":"Helical","end":955,"evidence":"ECO:0000255","source_location":"TRANSMEM 933..955; 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/evidence=\"ECO:0000269|PubMed:15340161\"","subcellular_location":"SUBCELLULAR LOCATION: Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:17081065}.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:25957687}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453}. Photoreceptor inner segment {ECO:0000250|UniProtKB:P18572}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:P18572}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:11992541, ECO:0000269|PubMed:15688292, ECO:0000269|PubMed:15946952, ECO:0000269|PubMed:17127621, ECO:0000269|PubMed:21536654, ECO:0000269|PubMed:25825981, ECO:0000269|PubMed:26195724, ECO:0000269|PubMed:28409866, ECO:0000269|PubMed:29739904}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453}. Endosome {ECO:0000269|PubMed:29739904}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:15688292}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453}. Basolateral cell membrane {ECO:0000269|PubMed:17267690}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453}.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane {ECO:0000269|PubMed:21536654}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453}.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane {ECO:0000269|PubMed:21536654}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453}.","topological_domain":"TOPO_DOM 138..325; /note=\"Extracellular\"; /evidence=\"ECO:0000269|PubMed:34625749, ECO:0000269|PubMed:38364890, ECO:0007744|PDB:7DCE, ECO:0007744|PDB:8XEJ\"; TOPO_DOM 345..385; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:34625749, ECO:0000269|PubMed:38364890, ECO:0007744|PDB:7DCE, ECO:0007744|PDB:8XEJ\"","transmembrane":"TRANSMEM 326..344; /note=\"Helical\"; /evidence=\"ECO:0000269|PubMed:34625749, ECO:0000269|PubMed:38364890, ECO:0007744|PDB:7DCE, ECO:0007744|PDB:8XEJ\""},"signal_peptides":[{"description":null,"end":21,"evidence":"ECO:0000269|PubMed:15340161","source_location":"SIGNAL 1..21; /evidence=\"ECO:0000269|PubMed:15340161\"","start":1}],"state":"available","topological_domains":[{"description":"Extracellular","end":325,"evidence":"ECO:0000269|PubMed:34625749, ECO:0000269|PubMed:38364890, ECO:0007744|PDB:7DCE, ECO:0007744|PDB:8XEJ","source_location":"TOPO_DOM 138..325; /note=\"Extracellular\"; /evidence=\"ECO:0000269|PubMed:34625749, ECO:0000269|PubMed:38364890, ECO:0007744|PDB:7DCE, ECO:0007744|PDB:8XEJ\"","start":138},{"description":"Cytoplasmic","end":385,"evidence":"ECO:0000269|PubMed:34625749, ECO:0000269|PubMed:38364890, ECO:0007744|PDB:7DCE, ECO:0007744|PDB:8XEJ","source_location":"TOPO_DOM 345..385; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:34625749, ECO:0000269|PubMed:38364890, ECO:0007744|PDB:7DCE, ECO:0007744|PDB:8XEJ\"","start":345}],"transmembrane_segments":[{"description":"Helical","end":344,"evidence":"ECO:0000269|PubMed:34625749, ECO:0000269|PubMed:38364890, ECO:0007744|PDB:7DCE, ECO:0007744|PDB:8XEJ","source_location":"TRANSMEM 326..344; /note=\"Helical\"; /evidence=\"ECO:0000269|PubMed:34625749, ECO:0000269|PubMed:38364890, ECO:0007744|PDB:7DCE, ECO:0007744|PDB:8XEJ\"","start":326}]},"uniprot_accession":"P35613"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000019582","evidence_rank":28,"extracellular_segments":{"records":[{"basis":"reviewed-uniprot-topological-domain","end":296,"evidence_class":"source-annotated-topology","length":224,"sequence":"QQQGRLDKLTVTSQNLQLENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQKPTDAPPKVLTKCQEEVSHIPAVHPGSFRPKCDENGNYLPLQCYGSIGYCWCVFPNGTEVPNTRSRGHHNCSESLELEDPSSGLGVTKQDLGPVPM","sequence_sha256":"4c6a65f31114216087588bc2f5a42600f9a25cb2046733fe44f984338750b607","start":73}],"state":"source-annotated"},"gene_symbol":"CD74","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQKPTDAPPKVLTKCQEEVSHIPAVHPGSFRPKCDENGNYLPLQCYGSIGYCWCVFPNGTEVPNTRSRGHHNCSESLELEDPSSGLGVTKQDLGPVPM","length":296,"sha256":"f6909ab67f84bc41d8ef8976b6e5634ebcb9031613d297ac41e582c377b48728","state":"available"},"source_refs":[{"artifact":{"bytes":10084,"format":"json","sha256":"b1919afcf582e3b8305172693c73112cf13c60cd65f10a4c46f32fba84141e9d","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/P04233"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"P04233","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"retained-unmodeled","target_id":"T-ENSG00000019582","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":296},"entry_name":"HG2A_HUMAN","gene_names":"CD74 DHLAG","lipidation_sites":[],"protein_names":"HLA class II histocompatibility antigen gamma chain (HLA-DR antigens-associated invariant chain) (Ia antigen-associated invariant chain) (Ii) (CD antigen CD74) [Cleaved into: Class-II-associated invariant chain peptide (CLIP)]","raw_fields":{"lipidation":"","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. 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/evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane; Single-pass type I membrane protein.","topological_domain":"TOPO_DOM 21..417; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 439..913; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 418..438; /note=\"Helical\"; /evidence=\"ECO:0000255\""},"signal_peptides":[{"description":null,"end":18,"evidence":"ECO:0000255","source_location":"SIGNAL 1..18; /evidence=\"ECO:0000255\"","start":1}],"state":"available","topological_domains":[{"description":"Extracellular","end":417,"evidence":"ECO:0000255","source_location":"TOPO_DOM 21..417; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":21},{"description":"Cytoplasmic","end":913,"evidence":"ECO:0000255","source_location":"TOPO_DOM 439..913; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":439}],"transmembrane_segments":[{"description":"Helical","end":438,"evidence":"ECO:0000255","source_location":"TRANSMEM 418..438; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":418}]},"uniprot_accession":"Q08345"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000168003","evidence_rank":30,"extracellular_segments":{"records":[{"basis":"reviewed-uniprot-topological-domain","end":529,"evidence_class":"source-annotated-topology","length":425,"sequence":"DTEVDMKEVELNELEPEKQPMNAASGAAMSLAGAEKNGLVKIKVAEDEAEAAAAAKFTGLSKEELLKVAGSPGWVRTRWALLLLFWLGWLGMLAGAVVIIVRAPRCRELPAQKWWHTGALYRIGDLQAFQGHGAGNLAGLKGRLDYLSSLKVKGLVLGPIHKNQKDDVAQTDLLQIDPNFGSKEDFDSLLQSAKKKSIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAGVDGFQVRDIENLKDASSFLAEWQNITKGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLTSSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQLLRLYQLMLFTLPGTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLSLFRRLSDQ","sequence_sha256":"ba948df48c2715bfe650c4e1e165d0b4921f4e010e6d0e46b1ea0147220a21e5","start":105}],"state":"source-annotated"},"gene_symbol":"SLC3A2","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MELQPPEASIAVVSIPRQLPGSHSEAGVQGLSAGDDSELGSHCVAQTGLELLASGDPLPSASQNAEMIETGSDCVTQAGLQLLASSDPPALASKNAEVTGTMSQDTEVDMKEVELNELEPEKQPMNAASGAAMSLAGAEKNGLVKIKVAEDEAEAAAAAKFTGLSKEELLKVAGSPGWVRTRWALLLLFWLGWLGMLAGAVVIIVRAPRCRELPAQKWWHTGALYRIGDLQAFQGHGAGNLAGLKGRLDYLSSLKVKGLVLGPIHKNQKDDVAQTDLLQIDPNFGSKEDFDSLLQSAKKKSIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAGVDGFQVRDIENLKDASSFLAEWQNITKGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLTSSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQLLRLYQLMLFTLPGTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLSLFRRLSDQRSKERSLLHGDFHAFSAGPGLFSYIRHWDQNERFLVVLNFGDVGLSAGLQASDLPASASLPAKADLLLSTQPGREEGSPLELERLKLEPHEGLLLRFPYAA","length":630,"sha256":"a5e0be8a99958752bb23ac1ad9cc11d2f70a195a87ba9879108527e694222761","state":"available"},"source_refs":[{"artifact":{"bytes":13710,"format":"json","sha256":"73d2dd0844982b5c46b0c0f92154ae9823f164f9d6615530dcf74353620dd2de","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/P08195"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"P08195","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"retained-unmodeled","target_id":"T-ENSG00000168003","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":630},"entry_name":"4F2_HUMAN","gene_names":"SLC3A2 MDU1","lipidation_sites":[],"protein_names":"Amino acid transporter heavy chain SLC3A2 (4F2 cell-surface antigen heavy chain) (4F2hc) (4F2 heavy chain antigen) (Lymphocyte activation antigen 4F2 large subunit) (Solute carrier family 3 member 2) (CD antigen CD98)","raw_fields":{"lipidation":"","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:11742812}. Cell membrane {ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:15769744, ECO:0000269|PubMed:16496379, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:3476959, ECO:0000269|PubMed:3480538, ECO:0000269|PubMed:36028562, ECO:0000269|PubMed:37918808, ECO:0000269|PubMed:9829974}; Single-pass type II membrane protein {ECO:0000269|PubMed:30867591}. Cell junction {ECO:0000250|UniProtKB:P10852}. Lysosome membrane {ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:40280132}. Melanosome {ECO:0000269|PubMed:17081065}. Basolateral cell membrane {ECO:0000250|UniProtKB:P10852}. Note=Localized at the plasma membrane when associated with SLC7A5/LAT1 or SLC7A8/LAT2 (PubMed:11311135, PubMed:9751058). Localized to the apical membrane of placental syncytiotrophoblastic cells (PubMed:11742812). Recruited to lysosomes by LAPTM4B (PubMed:25998567). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Located selectively at cell-cell adhesion sites (By similarity). Colocalized with SLC7A8/LAT2 at the basolateral membrane of kidney proximal tubules and small intestine epithelia. Expressed in both luminal and abluminal membranes of brain capillary endothelial cells (By similarity). {ECO:0000250|UniProtKB:P10852, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:9751058}.","topological_domain":"TOPO_DOM 2..83; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:11121428, ECO:0000269|PubMed:30867591\"; TOPO_DOM 105..529; /note=\"Extracellular\"; /evidence=\"ECO:0000269|PubMed:11121428, ECO:0000269|PubMed:30867591\"","transmembrane":"TRANSMEM 84..104; /note=\"Helical; Signal-anchor for type II membrane protein\"; /evidence=\"ECO:0000269|PubMed:30867591\""},"signal_peptides":[],"state":"available","topological_domains":[{"description":"Cytoplasmic","end":83,"evidence":"ECO:0000269|PubMed:11121428, ECO:0000269|PubMed:30867591","source_location":"TOPO_DOM 2..83; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:11121428, ECO:0000269|PubMed:30867591\"","start":2},{"description":"Extracellular","end":529,"evidence":"ECO:0000269|PubMed:11121428, ECO:0000269|PubMed:30867591","source_location":"TOPO_DOM 105..529; 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/evidence=\"ECO:0000255\"","start":163},{"description":"Extracellular","end":207,"evidence":"ECO:0000255","source_location":"TOPO_DOM 198..207; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":198},{"description":"Cytoplasmic","end":235,"evidence":"ECO:0000255","source_location":"TOPO_DOM 229..235; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":229},{"description":"Extracellular","end":268,"evidence":"ECO:0000255","source_location":"TOPO_DOM 257..268; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":257},{"description":"Cytoplasmic","end":323,"evidence":"ECO:0000255","source_location":"TOPO_DOM 290..323; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":290}],"transmembrane_segments":[{"description":"Helical","end":162,"evidence":"ECO:0000255","source_location":"TRANSMEM 142..162; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":142},{"description":"Helical","end":197,"evidence":"ECO:0000255","source_location":"TRANSMEM 177..197; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":177},{"description":"Helical","end":228,"evidence":"ECO:0000255","source_location":"TRANSMEM 208..228; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":208},{"description":"Helical","end":256,"evidence":"ECO:0000255","source_location":"TRANSMEM 236..256; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":236},{"description":"Helical","end":289,"evidence":"ECO:0000255","source_location":"TRANSMEM 269..289; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":269}]},"uniprot_accession":"Q08722"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000181143","evidence_rank":56,"extracellular_segments":{"records":[{"basis":"reviewed-uniprot-topological-domain","end":14451,"evidence_class":"source-annotated-topology","length":14451,"sequence":"MLKPSGLPGSSSPTRSLMTGSRSTKATPEMDSGLTGATLSPKTSTGAIVVTEHTLPFTSPDKTLASPTSSVVGRTTQSLGVMSSALPESTSRGMTHSEQRTSPSLSPQVNGTPSRNYPATSMVSGLSSPRTRTSSTEGNFTKEASTYTLTVETTSGPVTEKYTVPTETSTTEGDSTETPWDTRYIPVKITSPMKTFADSTASKENAPVSMTPAETTVTDSHTPGRTNPSFGTLYSSFLDLSPKGTPNSRGETSLELILSTTGYPFSSPEPGSAGHSRISTSAPLSSSASVLDNKISETSIFSGQSLTSPLSPGVPEARASTMPNSAIPFSMTLSNAETSAERVRSTISSLGTPSISTKQTAETILTFHAFAETMDIPSTHIAKTLASEWLGSPGTLGGTSTSALTTTSPSTTLVSEETNTHHSTSGKETEGTLNTSMTPLETSAPGEESEMTATLVPTLGFTTLDSKIRSPSQVSSSHPTRELRTTGSTSGRQSSSTAAHGSSDILRATTSSTSKASSWTSESTAQQFSEPQHTQWVETSPSMKTERPPASTSVAAPITTSVPSVVSGFTTLKTSSTKGIWLEETSADTLIGESTAGPTTHQFAVPTGISMTGGSSTRGSQGTTHLLTRATASSETSADLTLATNGVPVSVSPAVSKTAAGSSPPGGTKPSYTMVSSVIPETSSLQSSAFREGTSLGLTPLNTRHPFSSPEPDSAGHTKISTSIPLLSSASVLEDKVSATSTFSHHKATSSITTGTPEISTKTKPSSAVLSSMTLSNAATSPERVRNATSPLTHPSPSGEETAGSVLTLSTSAETTDSPNIHPTGTLTSESSESPSTLSLPSVSGVKTTFSSSTPSTHLFTSGEETEETSNPSVSQPETSVSRVRTTLASTSVPTPVFPTMDTWPTRSAQFSSSHLVSELRATSSTSVTNSTGSALPKISHLTGTATMSQTNRDTFNDSAAPQSTTWPETSPRFKTGLPSATTTVSTSATSLSATVMVSKFTSPATSSMEATSIREPSTTILTTETTNGPGSMAVASTNIPIGKGYITEGRLDTSHLPIGTTASSETSMDFTMAKESVSMSVSPSQSMDAAGSSTPGRTSQFVDTFSDDVYHLTSREITIPRDGTSSALTPQMTATHPPSPDPGSARSTWLGILSSSPSSPTPKVTMSSTFSTQRVTTSMIMDTVETSRWNMPNLPSTTSLTPSNIPTSGAIGKSTLVPLDTPSPATSLEASEGGLPTLSTYPESTNTPSIHLGAHASSESPSTIKLTMASVVKPGSYTPLTFPSIETHIHVSTARMAYSSGSSPEMTAPGETNTGSTWDPTTYITTTDPKDTSSAQVSTPHSVRTLRTTENHPKTESATPAAYSGSPKISSSPNLTSPATKAWTITDTTEHSTQLHYTKLAEKSSGFETQSAPGPVSVVIPTSPTIGSSTLELTSDVPGEPLVLAPSEQTTITLPMATWLSTSLTEEMASTDLDISSPSSPMSTFAIFPPMSTPSHELSKSEADTSAIRNTDSTTLDQHLGIRSLGRTGDLTTVPITPLTTTWTSVIEHSTQAQDTLSATMSPTHVTQSLKDQTSIPASASPSHLTEVYPELGTQGRSSSEATTFWKPSTDTLSREIETGPTNIQSTPPMDNTTTGSSSSGVTLGIAHLPIGTSSPAETSTNMALERRSSTATVSMAGTMGLLVTSAPGRSISQSLGRVSSVLSESTTEGVTDSSKGSSPRLNTQGNTALSSSLEPSYAEGSQMSTSIPLTSSPTTPDVEFIGGSTFWTKEVTTVMTSDISKSSARTESSSATLMSTALGSTENTGKEKLRTASMDLPSPTPSMEVTPWISLTLSNAPNTTDSLDLSHGVHTSSAGTLATDRSLNTGVTRASRLENGSDTSSKSLSMGNSTHTSMTYTEKSEVSSSIHPRPETSAPGAETTLTSTPGNRAISLTLPFSSIPVEEVISTGITSGPDINSAPMTHSPITPPTIVWTSTGTIEQSTQPLHAVSSEKVSVQTQSTPYVNSVAVSASPTHENSVSSGSSTSSPYSSASLESLDSTISRRNAITSWLWDLTTSLPTTTWPSTSLSEALSSGHSGVSNPSSTTTEFPLFSAASTSAAKQRNPETETHGPQNTAASTLNTDASSVTGLSETPVGASISSEVPLPMAITSRSDVSGLTSESTANPSLGTASSAGTKLTRTISLPTSESLVSFRMNKDPWTVSIPLGSHPTTNTETSIPVNSAGPPGLSTVASDVIDTPSDGAESIPTVSFSPSPDTEVTTISHFPEKTTHSFRTISSLTHELTSRVTPIPGDWMSSAMSTKPTGASPSITLGERRTITSAAPTTSPIVLTASFTETSTVSLDNETTVKTSDILDARKTNELPSDSSSSSDLINTSIASSTMDVTKTASISPTSISGMTASSSPSLFSSDRPQVPTSTTETNTATSPSVSSNTYSLDGGSNVGGTPSTLPPFTITHPVETSSALLAWSRPVRTFSTMVSTDTASGENPTSSNSVVTSVPAPGTWTSVGSTTDLPAMGFLKTSPAGEAHSLLASTIEPATAFTPHLSAAVVTGSSATSEASLLTTSESKAIHSSPQTPTTPTSGANWETSATPESLLVVTETSDTTLTSKILVTDTILFSTVSTPPSKFPSTGTLSGASFPTLLPDTPAIPLTATEPTSSLATSFDSTPLVTIASDSLGTVPETTLTMSETSNGDALVLKTVSNPDRSIPGITIQGVTESPLHPSSTSPSKIVAPRNTTYEGSITVALSTLPAGTTGSLVFSQSSENSETTALVDSSAGLERASVMPLTTGSQGMASSGGIRSGSTHSTGTKTFSSLPLTMNPGEVTAMSEITTNRLTATQSTAPKGIPVKPTSAESGLLTPVSASSSPSKAFASLTTAPPTWGIPQSTLTFEFSEVPSLDTKSASLPTPGQSLNTIPDSDASTASSSLSKSPEKNPRARMMTSTKAISASSFQSTGFTETPEGSASPSMAGHEPRVPTSGTGDPRYASESMSYPDPSKASSAMTSTSLASKLTTLFSTGQAARSGSSSSPISLSTEKETSFLSPTASTSRKTSLFLGPSMARQPNILVHLQTSALTLSPTSTLNMSQEEPPELTSSQTIAEEEGTTAETQTLTFTPSETPTSLLPVSSPTEPTARRKSSPETWASSISVPAKTSLVETTDGTLVTTIKMSSQAAQGNSTWPAPAEETGSSPAGTSPGSPEMSTTLKIMSSKEPSISPEIRSTVRNSPWKTPETTVPMETTVEPVTLQSTALGSGSTSISHLPTGTTSPTKSPTENMLATERVSLSPSPPEAWTNLYSGTPGGTRQSLATMSSVSLESPTARSITGTGQQSSPELVSKTTGMEFSMWHGSTGGTTGDTHVSLSTSSNILEDPVTSPNSVSSLTDKSKHKTETWVSTTAIPSTVLNNKIMAAEQQTSRSVDEAYSSTSSWSDQTSGSDITLGASPDVTNTLYITSTAQTTSLVSLPSGDQGITSLTNPSGGKTSSASSVTSPSIGLETLRANVSAVKSDIAPTAGHLSQTSSPAEVSILDVTTAPTPGISTTITTMGTNSISTTTPNPEVGMSTMDSTPATERRTTSTEHPSTWSSTAASDSWTVTDMTSNLKVARSPGTISTMHTTSFLASSTELDSMSTPHGRITVIGTSLVTPSSDASAVKTETSTSERTLSPSDTTASTPISTFSRVQRMSISVPDILSTSWTPSSTEAEDVPVSMVSTDHASTKTDPNTPLSTFLFDSLSTLDWDTGRSLSSATATTSAPQGATTPQELTLETMISPATSQLPFSIGHITSAVTPAAMARSSGVTFSRPDPTSKKAEQTSTQLPTTTSAHPGQVPRSAATTLDVIPHTAKTPDATFQRQGQTALTTEARATSDSWNEKEKSTPSAPWITEMMNSVSEDTIKEVTSSSSVLRTLNTLDINLESGTTSSPSWKSSPYERIAPSESTTDKEAIHPSTNTVETTGWVTSSEHASHSTIPAHSASSKLTSPVVTTSTREQAIVSMSTTTWPESTRARTEPNSFLTIELRDVSPYMDTSSTTQTSIISSPGSTAITKGPRTEITSSKRISSSFLAQSMRSSDSPSEAITRLSNFPAMTESGGMILAMQTSPPGATSLSAPTLDTSATASWTGTPLATTQRFTYSEKTTLFSKGPEDTSQPSPPSVEETSSSSSLVPIHATTSPSNILLTSQGHSPSSTPPVTSVFLSETSGLGKTTDMSRISLEPGTSLPPNLSSTAGEALSTYEASRDTKAIHHSADTAVTNMEATSSEYSPIPGHTKPSKATSPLVTSHIMGDITSSTSVFGSSETTEIETVSSVNQGLQERSTSQVASSATETSTVITHVSSGDATTHVTKTQATFSSGTSISSPHQFITSTNTFTDVSTNPSTSLIMTESSGVTITTQTGPTGAATQGPYLLDTSTMPYLTETPLAVTPDFMQSEKTTLISKGPKDVSWTSPPSVAETSYPSSLTPFLVTTIPPATSTLQGQHTSSPVSATSVLTSGLVKTTDMLNTSMEPVTNSPQNLNNPSNEILATLAATTDIETIHPSINKAVTNMGTASSAHVLHSTLPVSSEPSTATSPMVPASSMGDALASISIPGSETTDIEGEPTSSLTAGRKENSTLQEMNSTTESNIILSNVSVGAITEATKMEVPSFDATFIPTPAQSTKFPDIFSVASSRLSNSPPMTISTHMTTTQTGSSGATSKIPLALDTSTLETSAGTPSVVTEGFAHSKITTAMNNDVKDVSQTNPPFQDEASSPSSQAPVLVTTLPSSVAFTPQWHSTSSPVSMSSVLTSSLVKTAGKVDTSLETVTSSPQSMSNTLDDISVTSAATTDIETTHPSINTVVTNVGTTGSAFESHSTVSAYPEPSKVTSPNVTTSTMEDTTISRSIPKSSKTTRTETETTSSLTPKLRETSISQEITSSTETSTVPYKELTGATTEVSRTDVTSSSSTSFPGPDQSTVSLDISTETNTRLSTSPIMTESAEITITTQTGPHGATSQDTFTMDPSNTTPQAGIHSAMTHGFSQLDVTTLMSRIPQDVSWTSPPSVDKTSSPSSFLSSPAMTTPSLISSTLPEDKLSSPMTSLLTSGLVKITDILRTRLEPVTSSLPNFSSTSDKILATSKDSKDTKEIFPSINTEETNVKANNSGHESHSPALADSETPKATTQMVITTTVGDPAPSTSMPVHGSSETTNIKREPTYFLTPRLRETSTSQESSFPTDTSFLLSKVPTGTITEVSSTGVNSSSKISTPDHDKSTVPPDTFTGEIPRVFTSSIKTKSAEMTITTQASPPESASHSTLPLDTSTTLSQGGTHSTVTQGFPYSEVTTLMGMGPGNVSWMTTPPVEETSSVSSLMSSPAMTSPSPVSSTSPQSIPSSPLPVTALPTSVLVTTTDVLGTTSPESVTSSPPNLSSITHERPATYKDTAHTEAAMHHSTNTAVTNVGTSGSGHKSQSSVLADSETSKATPLMSTTSTLGDTSVSTSTPNISQTNQIQTEPTASLSPRLRESSTSEKTSSTTETNTAFSYVPTGAITQASRTEISSSRTSISDLDRPTIAPDISTGMITRLFTSPIMTKSAEMTVTTQTTTPGATSQGILPWDTSTTLFQGGTHSTVSQGFPHSEITTLRSRTPGDVSWMTTPPVEETSSGFSLMSPSMTSPSPVSSTSPESIPSSPLPVTALLTSVLVTTTNVLGTTSPEPVTSSPPNLSSPTQERLTTYKDTAHTEAMHASMHTNTAVANVGTSISGHESQSSVPADSHTSKATSPMGITFAMGDTSVSTSTPAFFETRIQTESTSSLIPGLRDTRTSEEINTVTETSTVLSEVPTTTTTEVSRTEVITSSRTTISGPDHSKMSPYISTETITRLSTFPFVTGSTEMAITNQTGPIGTISQATLTLDTSSTASWEGTHSPVTQRFPHSEETTTMSRSTKGVSWQSPPSVEETSSPSSPVPLPAITSHSSLYSAVSGSSPTSALPVTSLLTSGRRKTIDMLDTHSELVTSSLPSASSFSGEILTSEASTNTETIHFSENTAETNMGTTNSMHKLHSSVSIHSQPSGHTPPKVTGSMMEDAIVSTSTPGSPETKNVDRDSTSPLTPELKEDSTALVMNSTTESNTVFSSVSLDAATEVSRAEVTYYDPTFMPASAQSTKSPDISPEASSSHSNSPPLTISTHKTIATQTGPSGVTSLGQLTLDTSTIATSAGTPSARTQDFVDSETTSVMNNDLNDVLKTSPFSAEEANSLSSQAPLLVTTSPSPVTSTLQEHSTSSLVSVTSVPTPTLAKITDMDTNLEPVTRSPQNLRNTLATSEATTDTHTMHPSINTAVANVGTTSSPNEFYFTVSPDSDPYKATSAVVITSTSGDSIVSTSMPRSSAMKKIESETTFSLIFRLRETSTSQKIGSSSDTSTVFDKAFTAATTEVSRTELTSSSRTSIQGTEKPTMSPDTSTRSVTMLSTFAGLTKSEERTIATQTGPHRATSQGTLTWDTSITTSQAGTHSAMTHGFSQLDLSTLTSRVPEYISGTSPPSVEKTSSSSSLLSLPAITSPSPVPTTLPESRPSSPVHLTSLPTSGLVKTTDMLASVASLPPNLGSTSHKIPTTSEDIKDTEKMYPSTNIAVTNVGTTTSEKESYSSVPAYSEPPKVTSPMVTSFNIRDTIVSTSMPGSSEITRIEMESTFSLAHGLKGTSTSQDPIVSTEKSAVLHKLTTGATETSRTEVASSRRTSIPGPDHSTESPDISTEVIPSLPISLGITESSNMTIITRTGPPLGSTSQGTFTLDTPTTSSRAGTHSMATQEFPHSEMTTVMNKDPEILSWTIPPSIEKTSFSSSLMPSPAMTSPPVSSTLPKTIHTTPSPMTSLLTPSLVMTTDTLGTSPEPTTSSPPNLSSTSHEILTTDEDTTAIEAMHPSTSTAATNVETTSSGHGSQSSVLADSEKTKATAPMDTTSTMGHTTVSTSMSVSSETTKIKRESTYSLTPGLRETSISQNASFSTDTSIVLSEVPTGTTAEVSRTEVTSSGRTSIPGPSQSTVLPEISTRTMTRLFASPTMTESAEMTIPTQTGPSGSTSQDTLTLDTSTTKSQAKTHSTLTQRFPHSEMTTLMSRGPGDMSWQSSPSLENPSSLPSLLSLPATTSPPPISSTLPVTISSSPLPVTSLLTSSPVTTTDMLHTSPELVTSSPPKLSHTSDERLTTGKDTTNTEAVHPSTNTAASNVEIPSSGHESPSSALADSETSKATSPMFITSTQEDTTVAISTPHFLETSRIQKESISSLSPKLRETGSSVETSSAIETSAVLSEVSIGATTEISRTEVTSSSRTSISGSAESTMLPEISTTRKIIKFPTSPILAESSEMTIKTQTSPPGSTSESTFTLDTSTTPSLVITHSTMTQRLPHSEITTLVSRGAGDVPRPSSLPVEETSPPSSQLSLSAMISPSPVSSTLPASSHSSSASVTSLLTPGQVKTTEVLDASAEPETSSPPSLSSTSVEILATSEVTTDTEKIHPFSNTAVTKVGTSSSGHESPSSVLPDSETTKATSAMGTISIMGDTSVSTLTPALSNTRKIQSEPASSLTTRLRETSTSEETSLATEANTVLSKVSTGATTEVSRTEAISFSRTSMSGPEQSTMSQDISIGTIPRISASSVLTESAKMTITTQTGPSESTLESTLNLNTATTPSWVETHSIVIQGFPHPEMTTSMGRGPGGVSWPSPPFVKETSPPSSPLSLPAVTSPHPVSTTFLAHIPPSPLPVTSLLTSGPATTTDILGTSTEPGTSSSSSLSTTSHERLTTYKDTAHTEAVHPSTNTGGTNVATTSSGYKSQSSVLADSSPMCTTSTMGDTSVLTSTPAFLETRRIQTELASSLTPGLRESSGSEGTSSGTKMSTVLSKVPTGATTEISKEDVTSIPGPAQSTISPDISTRTVSWFSTSPVMTESAEITMNTHTSPLGATTQGTSTLDTSSTTSLTMTHSTISQGFSHSQMSTLMRRGPEDVSWMSPPLLEKTRPSFSLMSSPATTSPSPVSSTLPESISSSPLPVTSLLTSGLAKTTDMLHKSSEPVTNSPANLSSTSVEILATSEVTTDTEKTHPSSNRTVTDVGTSSSGHESTSFVLADSQTSKVTSPMVITSTMEDTSVSTSTPGFFETSRIQTEPTSSLTLGLRKTSSSEGTSLATEMSTVLSGVPTGATAEVSRTEVTSSSRTSISGFAQLTVSPETSTETITRLPTSSIMTESAEMMIKTQTDPPGSTPESTHTVDISTTPNWVETHSTVTQRFSHSEMTTLVSRSPGDMLWPSQSSVEETSSASSLLSLPATTSPSPVSSTLVEDFPSASLPVTSLLNPGLVITTDRMGISREPGTSSTSNLSSTSHERLTTLEDTVDTEDMQPSTHTAVTNVRTSISGHESQSSVLSDSETPKATSPMGTTYTMGETSVSISTSDFFETSRIQIEPTSSLTSGLRETSSSERISSATEGSTVLSEVPSGATTEVSRTEVISSRGTSMSGPDQFTISPDISTEAITRLSTSPIMTESAESAITIETGSPGATSEGTLTLDTSTTTFWSGTHSTASPGFSHSEMTTLMSRTPGDVPWPSLPSVEEASSVSSSLSSPAMTSTSFFSTLPESISSSPHPVTALLTLGPVKTTDMLRTSSEPETSSPPNLSSTSAEILATSEVTKDREKIHPSSNTPVVNVGTVIYKHLSPSSVLADLVTTKPTSPMATTSTLGNTSVSTSTPAFPETMMTQPTSSLTSGLREISTSQETSSATERSASLSGMPTGATTKVSRTEALSLGRTSTPGPAQSTISPEISTETITRISTPLTTTGSAEMTITPKTGHSGASSQGTFTLDTSSRASWPGTHSAATHRSPHSGMTTPMSRGPEDVSWPSRPSVEKTSPPSSLVSLSAVTSPSPLYSTPSESSHSSPLRVTSLFTPVMMKTTDMLDTSLEPVTTSPPSMNITSDESLATSKATMETEAIQLSENTAVTQMGTISARQEFYSSYPGLPEPSKVTSPVVTSSTIKDIVSTTIPASSEITRIEMESTSTLTPTPRETSTSQEIHSATKPSTVPYKALTSATIEDSMTQVMSSSRGPSPDQSTMSQDISTEVITRLSTSPIKTESTEMTITTQTGSPGATSRGTLTLDTSTTFMSGTHSTASQGFSHSQMTALMSRTPGDVPWLSHPSVEEASSASFSLSSPVMTSSSPVSSTLPDSIHSSSLPVTSLLTSGLVKTTELLGTSSEPETSSPPNLSSTSAEILAITEVTTDTEKLEMTNVVTSGYTHESPSSVLADSVTTKATSSMGITYPTGDTNVLTSTPAFSDTSRIQTKSKLSLTPGLMETSISEETSSATEKSTVLSSVPTGATTEVSRTEAISSSRTSIPGPAQSTMSSDTSMETITRISTPLTRKESTDMAITPKTGPSGATSQGTFTLDSSSTASWPGTHSATTQRFPQSVVTTPMSRGPEDVSWPSPLSVEKNSPPSSLVSSSSVTSPSPLYSTPSGSSHSSPVPVTSLFTSIMMKATDMLDASLEPETTSAPNMNITSDESLAASKATTETEAIHVFENTAASHVETTSATEELYSSSPGFSEPTKVISPVVTSSSIRDNMVSTTMPGSSGITRIEIESMSSLTPGLRETRTSQDITSSTETSTVLYKMPSGATPEVSRTEVMPSSRTSIPGPAQSTMSLDISDEVVTRLSTSPIMTESAEITITTQTGYSLATSQVTLPLGTSMTFLSGTHSTMSQGLSHSEMTNLMSRGPESLSWTSPRFVETTRSSSSLTSLPLTTSLSPVSSTLLDSSPSSPLPVTSLILPGLVKTTEVLDTSSEPKTSSSPNLSSTSVEIPATSEIMTDTEKIHPSSNTAVAKVRTSSSVHESHSSVLADSETTITIPSMGITSAVDDTTVFTSNPAFSETRRIPTEPTFSLTPGFRETSTSEETTSITETSAVLYGVPTSATTEVSMTEIMSSNRIHIPDSDQSTMSPDIITEVITRLSSSSMMSESTQMTITTQKSSPGATAQSTLTLATTTAPLARTHSTVPPRFLHSEMTTLMSRSPENPSWKSSLFVEKTSSSSSLLSLPVTTSPSVSSTLPQSIPSSSFSVTSLLTPGMVKTTDTSTEPGTSLSPNLSGTSVEILAASEVTTDTEKIHPSSSMAVTNVGTTSSGHELYSSVSIHSEPSKATYPVGTPSSMAETSISTSMPANFETTGFEAEPFSHLTSGFRKTNMSLDTSSVTPTNTPSSPGSTHLLQSSKTDFTSSAKTSSPDWPPASQYTEIPVDIITPFNASPSITESTGITSFPESRFTMSVTESTHHLSTDLLPSAETISTGTVMPSLSEAMTSFATTGVPRAISGSGSPFSRTESGPGDATLSTIAESLPSSTPVPFSSSTFTTTDSSTIPALHEITSSSATPYRVDTSLGTESSTTEGRLVMVSTLDTSSQPGRTSSSPILDTRMTESVELGTVTSAYQVPSLSTRLTRTDGIMEHITKIPNEAAHRGTIRPVKGPQTSTSPASPKGLHTGGTKRMETTTTALKTTTTALKTTSRATLTTSVYTPTLGTLTPLNASMQMASTIPTEMMITTPYVFPDVPETTSSLATSLGAETSTALPRTTPSVFNRESETTASLVSRSGAERSPVIQTLDVSSSEPDTTASWVIHPAETIPTVSKTTPNFFHSELDTVSSTATSHGADVSSAIPTNISPSELDALTPLVTISGTDTSTTFPTLTKSPHETETRTTWLTHPAETSSTIPRTIPNFSHHESDATPSIATSPGAETSSAIPIMTVSPGAEDLVTSQVTSSGTDRNMTIPTLTLSPGEPKTIASLVTHPEAQTSSAIPTSTISPAVSRLVTSMVTSLAAKTSTTNRALTNSPGEPATTVSLVTHPAQTSPTVPWTTSIFFHSKSDTTPSMTTSHGAESSSAVPTPTVSTEVPGVVTPLVTSSRAVISTTIPILTLSPGEPETTPSMATSHGEEASSAIPTPTVSPGVPGVVTSLVTSSRAVTSTTIPILTFSLGEPETTPSMATSHGTEAGSAVPTVLPEVPGMVTSLVASSRAVTSTTLPTLTLSPGEPETTPSMATSHGAEASSTVPTVSPEVPGVVTSLVTSSSGVNSTSIPTLILSPGELETTPSMATSHGAEASSAVPTPTVSPGVSGVVTPLVTSSRAVTSTTIPILTLSSSEPETTPSMATSHGVEASSAVLTVSPEVPGMVTSLVTSSRAVTSTTIPTLTISSDEPETTTSLVTHSEAKMISAIPTLAVSPTVQGLVTSLVTSSGSETSAFSNLTVASSQPETIDSWVAHPGTEASSVVPTLTVSTGEPFTNISLVTHPAESSSTLPRTTSRFSHSELDTMPSTVTSPEAESSSAISTTISPGIPGVLTSLVTSSGRDISATFPTVPESPHESEATASWVTHPAVTSTTVPRTTPNYSHSEPDTTPSIATSPGAEATSDFPTITVSPDVPDMVTSQVTSSGTDTSITIPTLTLSSGEPETTTSFITYSETHTSSAIPTLPVSPGASKMLTSLVISSGTDSTTTFPTLTETPYEPETTAIQLIHPAETNTMVPRTTPKFSHSKSDTTLPVAITSPGPEASSAVSTTTISPDMSDLVTSLVPSSGTDTSTTFPTLSETPYEPETTATWLTHPAETSTTVSGTIPNFSHRGSDTAPSMVTSPGVDTRSGVPTTTIPPSIPGVVTSQVTSSATDTSTAIPTLTPSPGEPETTASSATHPGTQTGFTVPIRTVPSSEPDTMASWVTHPPQTSTPVSRTTSSFSHSSPDATPVMATSPRTEASSAVLTTISPGAPEMVTSQITSSGAATSTTVPTLTHSPGMPETTALLSTHPRTETSKTFPASTVFPQVSETTASLTIRPGAETSTALPTQTTSSLFTLLVTGTSRVDLSPTASPGVSAKTAPLSTHPGTETSTMIPTSTLSLGLLETTGLLATSSSAETSTSTLTLTVSPAVSGLSSASITTDKPQTVTSWNTETSPSVTSVGPPEFSRTVTGTTMTLIPSEMPTPPKTSHGEGVSPTTILRTTMVEATNLATTGSSPTVAKTTTTFNTLAGSLFTPLTTPGMSTLASESVTSRTSYNHRSWISTTSSYNRRYWTPATSTPVTSTFSPGISTSSIPSSTAATVPFMVPFTLNFTITNLQYEEDMRHPGSRKFNATERELQGLLKPLFRNSSLEYLYSGCRLASLRPEKDSSATAVDAICTHRPDPEDLGLDRERLYWELSNLTNGIQELGPYTLDRNSLYVNGFTHRSSMPTTSTPGTSTVDVGTSGTPSSSPSPTTAGPLLMPFTLNFTITNLQYEEDMRRTGSRKFNTMESVLQGLLKPLFKNTSVGPLYSGCRLTLLRPEKDGAATGVDAICTHRLDPKSPGLNREQLYWELSKLTNDIEELGPYTLDRNSLYVNGFTHQSSVSTTSTPGTSTVDLRTSGTPSSLSSPTIMAAGPLLVPFTLNFTITNLQYGEDMGHPGSRKFNTTERVLQGLLGPIFKNTSVGPLYSGCRLTSLRSEKDGAATGVDAICIHHLDPKSPGLNRERLYWELSQLTNGIKELGPYTLDRNSLYVNGFTHRTSVPTSSTPGTSTVDLGTSGTPFSLPSPATAGPLLVLFTLNFTITNLKYEEDMHRPGSRKFNTTERVLQTLLGPMFKNTSVGLLYSGCRLTLLRSEKDGAATGVDAICTHRLDPKSPGVDREQLYWELSQLTNGIKELGPYTLDRNSLYVNGFTHWIPVPTSSTPGTSTVDLGSGTPSSLPSPTTAGPLLVPFTLNFTITNLKYEEDMHCPGSRKFNTTERVLQSLLGPMFKNTSVGPLYSGCRLTLLRSEKDGAATGVDAICTHRLDPKSPGVDREQLYWELSQLTNGIKELGPYTLDRNSLYVNGFTHQTSAPNTSTPGTSTVDLGTSGTPSSLPSPTSAGPLLVPFTLNFTITNLQYEEDMHHPGSRKFNTTERVLQGLLGPMFKNTSVGLLYSGCRLTLLRPEKNGAATGMDAICSHRLDPKSPGLNREQLYWELSQLTHGIKELGPYTLDRNSLYVNGFTHRSSVAPTSTPGTSTVDLGTSGTPSSLPSPTTAVPLLVPFTLNFTITNLQYGEDMRHPGSRKFNTTERVLQGLLGPLFKNSSVGPLYSGCRLISLRSEKDGAATGVDAICTHHLNPQSPGLDREQLYWQLSQMTNGIKELGPYTLDRNSLYVNGFTHRSSGLTTSTPWTSTVDLGTSGTPSPVPSPTTTGPLLVPFTLNFTITNLQYEENMGHPGSRKFNITESVLQGLLKPLFKSTSVGPLYSGCRLTLLRPEKDGVATRVDAICTHRPDPKIPGLDRQQLYWELSQLTHSITELGPYTLDRDSLYVNGFTQRSSVPTTSTPGTFTVQPETSETPSSLPGPTATGPVLLPFTLNFTITNLQYEEDMRRPGSRKFNTTERVLQGLLMPLFKNTSVSSLYSGCRLTLLRPEKDGAATRVDAVCTHRPDPKSPGLDRERLYWKLSQLTHGITELGPYTLDRHSLYVNGFTHQSSMTTTRTPDTSTMHLATSRTPASLSGPMTASPLLVLFTINFTITNLRYEENMHHPGSRKFNTTERVLQGLLRPVFKNTSVGPLYSGCRLTLLRPKKDGAATKVDAICTYRPDPKSPGLDREQLYWELSQLTHSITELGPYTLDRDSLYVNGFTQRSSVPTTSIPGTPTVDLGTSGTPVSKPGPSAASPLLVLFTLNFTITNLRYEENMQHPGSRKFNTTERVLQGLLRSLFKSTSVGPLYSGCRLTLLRPEKDGTATGVDAICTHHPDPKSPRLDREQLYWELSQLTHNITELGPYALDNDSLFVNGFTHRSSVSTTSTPGTPTVYLGASKTPASIFGPSAASHLLILFTLNFTITNLRYEENMWPGSRKFNTTERVLQGLLRPLFKNTSVGPLYSGCRLTLLRPEKDGEATGVDAICTHRPDPTGPGLDREQLYLELSQLTHSITELGPYTLDRDSLYVNGFTHRSSVPTTSTGVVSEEPFTLNFTINNLRYMADMGQPGSLKFNITDNVMQHLLSPLFQRSSLGARYTGCRVIALRSVKNGAETRVDLLCTYLQPLSGPGLPIKQVFHELSQQTHGITRLGPYSLDKDSLYLNGYNEPGPDEPPTTPKPATTFLPPLSEATTAMGYHLKTLTLNFTISNLQYSPDMGKGSATFNSTEGVLQHLLRPLFQKSSMGPFYLGCQLISLRPEKDGAATGVDTTCTYHPDPVGPGLDIQQLYWELSQLTHGVTQLGFYVLDRDSLFINGYAPQNLSIRGEYQINFHIVNWNLSNPDPTSSEYITLLRDIQDKVTTLYKGSQLHDTFRFCLVTNLTMDSVLVTVKALFSSNLDPSLVEQVFLDKTLNASFHWLGSTYQLVDIHVTEMESSVYQPTSSSSTQHFYLNFTITNLPYSQDKAQPGTTNYQRNKRNIEDALNQLFRNSSIKSYFSDCQVSTFRSVPNRHHTGVDSLCNFSPLARRVDRVAIYEEFLRMTRNGTQLQNFTLDRSSVLVDGYSPNRNEPLTGNSDLP","sequence_sha256":"e9d873eb4d0dd31f72aff5596fbb063cfc72adac7703d8fb4033cbd2a6913247","start":1}],"state":"source-annotated"},"gene_symbol":"MUC16","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MLKPSGLPGSSSPTRSLMTGSRSTKATPEMDSGLTGATLSPKTSTGAIVVTEHTLPFTSPDKTLASPTSSVVGRTTQSLGVMSSALPESTSRGMTHSEQRTSPSLSPQVNGTPSRNYPATSMVSGLSSPRTRTSSTEGNFTKEASTYTLTVETTSGPVTEKYTVPTETSTTEGDSTETPWDTRYIPVKITSPMKTFADSTASKENAPVSMTPAETTVTDSHTPGRTNPSFGTLYSSFLDLSPKGTPNSRGETSLELILSTTGYPFSSPEPGSAGHSRISTSAPLSSSASVLDNKISETSIFSGQSLTSPLSPGVPEARASTMPNSAIPFSMTLSNAETSAERVRSTISSLGTPSISTKQTAETILTFHAFAETMDIPSTHIAKTLASEWLGSPGTLGGTSTSALTTTSPSTTLVSEETNTHHSTSGKETEGTLNTSMTPLETSAPGEESEMTATLVPTLGFTTLDSKIRSPSQVSSSHPTRELRTTGSTSGRQSSSTAAHGSSDILRATTSSTSKASSWTSESTAQQFSEPQHTQWVETSPSMKTERPPASTSVAAPITTSVPSVVSGFTTLKTSSTKGIWLEETSADTLIGESTAGPTTHQFAVPTGISMTGGSSTRGSQGTTHLLTRATASSETSADLTLATNGVPVSVSPAVSKTAAGSSPPGGTKPSYTMVSSVIPETSSLQSSAFREGTSLGLTPLNTRHPFSSPEPDSAGHTKISTSIPLLSSASVLEDKVSATSTFSHHKATSSITTGTPEISTKTKPSSAVLSSMTLSNAATSPERVRNATSPLTHPSPSGEETAGSVLTLSTSAETTDSPNIHPTGTLTSESSESPSTLSLPSVSGVKTTFSSSTPSTHLFTSGEETEETSNPSVSQPETSVSRVRTTLASTSVPTPVFPTMDTWPTRSAQFSSSHLVSELRATSSTSVTNSTGSALPKISHLTGTATMSQTNRDTFNDSAAPQSTTWPETSPRFKTGLPSATTTVSTSATSLSATVMVSKFTSPATSSMEATSIREPSTTILTTETTNGPGSMAVASTNIPIGKGYITEGRLDTSHLPIGTTASSETSMDFTMAKESVSMSVSPSQSMDAAGSSTPGRTSQFVDTFSDDVYHLTSREITIPRDGTSSALTPQMTATHPPSPDPGSARSTWLGILSSSPSSPTPKVTMSSTFSTQRVTTSMIMDTVETSRWNMPNLPSTTSLTPSNIPTSGAIGKSTLVPLDTPSPATSLEASEGGLPTLSTYPESTNTPSIHLGAHASSESPSTIKLTMASVVKPGSYTPLTFPSIETHIHVSTARMAYSSGSSPEMTAPGETNTGSTWDPTTYITTTDPKDTSSAQVSTPHSVRTLRTTENHPKTESATPAAYSGSPKISSSPNLTSPATKAWTITDTTEHSTQLHYTKLAEKSSGFETQSAPGPVSVVIPTSPTIGSSTLELTSDVPGEPLVLAPSEQTTITLPMATWLSTSLTEEMASTDLDISSPSSPMSTFAIFPPMSTPSHELSKSEADTSAIRNTDSTTLDQHLGIRSLGRTGDLTTVPITPLTTTWTSVIEHSTQAQDTLSATMSPTHVTQSLKDQTSIPASASPSHLTEVYPELGTQGRSSSEATTFWKPSTDTLSREIETGPTNIQSTPPMDNTTTGSSSSGVTLGIAHLPIGTSSPAETSTNMALERRSSTATVSMAGTMGLLVTSAPGRSISQSLGRVSSVLSESTTEGVTDSSKGSSPRLNTQGNTALSSSLEPSYAEGSQMSTSIPLTSSPTTPDVEFIGGSTFWTKEVTTVMTSDISKSSARTESSSATLMSTALGSTENTGKEKLRTASMDLPSPTPSMEVTPWISLTLSNAPNTTDSLDLSHGVHTSSAGTLATDRSLNTGVTRASRLENGSDTSSKSLSMGNSTHTSMTYTEKSEVSSSIHPRPETSAPGAETTLTSTPGNRAISLTLPFSSIPVEEVISTGITSGPDINSAPMTHSPITPPTIVWTSTGTIEQSTQPLHAVSSEKVSVQTQSTPYVNSVAVSASPTHENSVSSGSSTSSPYSSASLESLDSTISRRNAITSWLWDLTTSLPTTTWPSTSLSEALSSGHSGVSNPSSTTTEFPLFSAASTSAAKQRNPETETHGPQNTAASTLNTDASSVTGLSETPVGASISSEVPLPMAITSRSDVSGLTSESTANPSLGTASSAGTKLTRTISLPTSESLVSFRMNKDPWTVSIPLGSHPTTNTETSIPVNSAGPPGLSTVASDVIDTPSDGAESIPTVSFSPSPDTEVTTISHFPEKTTHSFRTISSLTHELTSRVTPIPGDWMSSAMSTKPTGASPSITLGERRTITSAAPTTSPIVLTASFTETSTVSLDNETTVKTSDILDARKTNELPSDSSSSSDLINTSIASSTMDVTKTASISPTSISGMTASSSPSLFSSDRPQVPTSTTETNTATSPSVSSNTYSLDGGSNVGGTPSTLPPFTITHPVETSSALLAWSRPVRTFSTMVSTDTASGENPTSSNSVVTSVPAPGTWTSVGSTTDLPAMGFLKTSPAGEAHSLLASTIEPATAFTPHLSAAVVTGSSATSEASLLTTSESKAIHSSPQTPTTPTSGANWETSATPESLLVVTETSDTTLTSKILVTDTILFSTVSTPPSKFPSTGTLSGASFPTLLPDTPAIPLTATEPTSSLATSFDSTPLVTIASDSLGTVPETTLTMSETSNGDALVLKTVSNPDRSIPGITIQGVTESPLHPSSTSPSKIVAPRNTTYEGSITVALSTLPAGTTGSLVFSQSSENSETTALVDSSAGLERASVMPLTTGSQGMASSGGIRSGSTHSTGTKTFSSLPLTMNPGEVTAMSEITTNRLTATQSTAPKGIPVKPTSAESGLLTPVSASSSPSKAFASLTTAPPTWGIPQSTLTFEFSEVPSLDTKSASLPTPGQSLNTIPDSDASTASSSLSKSPEKNPRARMMTSTKAISASSFQSTGFTETPEGSASPSMAGHEPRVPTSGTGDPRYASESMSYPDPSKASSAMTSTSLASKLTTLFSTGQAARSGSSSSPISLSTEKETSFLSPTASTSRKTSLFLGPSMARQPNILVHLQTSALTLSPTSTLNMSQEEPPELTSSQTIAEEEGTTAETQTLTFTPSETPTSLLPVSSPTEPTARRKSSPETWASSISVPAKTSLVETTDGTLVTTIKMSSQAAQGNSTWPAPAEETGSSPAGTSPGSPEMSTTLKIMSSKEPSISPEIRSTVRNSPWKTPETTVPMETTVEPVTLQSTALGSGSTSISHLPTGTTSPTKSPTENMLATERVSLSPSPPEAWTNLYSGTPGGTRQSLATMSSVSLESPTARSITGTGQQSSPELVSKTTGMEFSMWHGSTGGTTGDTHVSLSTSSNILEDPVTSPNSVSSLTDKSKHKTETWVSTTAIPSTVLNNKIMAAEQQTSRSVDEAYSSTSSWSDQTSGSDITLGASPDVTNTLYITSTAQTTSLVSLPSGDQGITSLTNPSGGKTSSASSVTSPSIGLETLRANVSAVKSDIAPTAGHLSQTSSPAEVSILDVTTAPTPGISTTITTMGTNSISTTTPNPEVGMSTMDSTPATERRTTSTEHPSTWSSTAASDSWTVTDMTSNLKVARSPGTISTMHTTSFLASSTELDSMSTPHGRITVIGTSLVTPSSDASAVKTETSTSERTLSPSDTTASTPISTFSRVQRMSISVPDILSTSWTPSSTEAEDVPVSMVSTDHASTKTDPNTPLSTFLFDSLSTLDWDTGRSLSSATATTSAPQGATTPQELTLETMISPATSQLPFSIGHITSAVTPAAMARSSGVTFSRPDPTSKKAEQTSTQLPTTTSAHPGQVPRSAATTLDVIPHTAKTPDATFQRQGQTALTTEARATSDSWNEKEKSTPSAPWITEMMNSVSEDTIKEVTSSSSVLRTLNTLDINLESGTTSSPSWKSSPYERIAPSESTTDKEAIHPSTNTVETTGWVTSSEHASHSTIPAHSASSKLTSPVVTTSTREQAIVSMSTTTWPESTRARTEPNSFLTIELRDVSPYMDTSSTTQTSIISSPGSTAITKGPRTEITSSKRISSSFLAQSMRSSDSPSEAITRLSNFPAMTESGGMILAMQTSPPGATSLSAPTLDTSATASWTGTPLATTQRFTYSEKTTLFSKGPEDTSQPSPPSVEETSSSSSLVPIHATTSPSNILLTSQGHSPSSTPPVTSVFLSETSGLGKTTDMSRISLEPGTSLPPNLSSTAGEALSTYEASRDTKAIHHSADTAVTNMEATSSEYSPIPGHTKPSKATSPLVTSHIMGDITSSTSVFGSSETTEIETVSSVNQGLQERSTSQVASSATETSTVITHVSSGDATTHVTKTQATFSSGTSISSPHQFITSTNTFTDVSTNPSTSLIMTESSGVTITTQTGPTGAATQGPYLLDTSTMPYLTETPLAVTPDFMQSEKTTLISKGPKDVSWTSPPSVAETSYPSSLTPFLVTTIPPATSTLQGQHTSSPVSATSVLTSGLVKTTDMLNTSMEPVTNSPQNLNNPSNEILATLAATTDIETIHPSINKAVTNMGTASSAHVLHSTLPVSSEPSTATSPMVPASSMGDALASISIPGSETTDIEGEPTSSLTAGRKENSTLQEMNSTTESNIILSNVSVGAITEATKMEVPSFDATFIPTPAQSTKFPDIFSVASSRLSNSPPMTISTHMTTTQTGSSGATSKIPLALDTSTLETSAGTPSVVTEGFAHSKITTAMNNDVKDVSQTNPPFQDEASSPSSQAPVLVTTLPSSVAFTPQWHSTSSPVSMSSVLTSSLVKTAGKVDTSLETVTSSPQSMSNTLDDISVTSAATTDIETTHPSINTVVTNVGTTGSAFESHSTVSAYPEPSKVTSPNVTTSTMEDTTISRSIPKSSKTTRTETETTSSLTPKLRETSISQEITSSTETSTVPYKELTGATTEVSRTDVTSSSSTSFPGPDQSTVSLDISTETNTRLSTSPIMTESAEITITTQTGPHGATSQDTFTMDPSNTTPQAGIHSAMTHGFSQLDVTTLMSRIPQDVSWTSPPSVDKTSSPSSFLSSPAMTTPSLISSTLPEDKLSSPMTSLLTSGLVKITDILRTRLEPVTSSLPNFSSTSDKILATSKDSKDTKEIFPSINTEETNVKANNSGHESHSPALADSETPKATTQMVITTTVGDPAPSTSMPVHGSSETTNIKREPTYFLTPRLRETSTSQESSFPTDTSFLLSKVPTGTITEVSSTGVNSSSKISTPDHDKSTVPPDTFTGEIPRVFTSSIKTKSAEMTITTQASPPESASHSTLPLDTSTTLSQGGTHSTVTQGFPYSEVTTLMGMGPGNVSWMTTPPVEETSSVSSLMSSPAMTSPSPVSSTSPQSIPSSPLPVTALPTSVLVTTTDVLGTTSPESVTSSPPNLSSITHERPATYKDTAHTEAAMHHSTNTAVTNVGTSGSGHKSQSSVLADSETSKATPLMSTTSTLGDTSVSTSTPNISQTNQIQTEPTASLSPRLRESSTSEKTSSTTETNTAFSYVPTGAITQASRTEISSSRTSISDLDRPTIAPDISTGMITRLFTSPIMTKSAEMTVTTQTTTPGATSQGILPWDTSTTLFQGGTHSTVSQGFPHSEITTLRSRTPGDVSWMTTPPVEETSSGFSLMSPSMTSPSPVSSTSPESIPSSPLPVTALLTSVLVTTTNVLGTTSPEPVTSSPPNLSSPTQERLTTYKDTAHTEAMHASMHTNTAVANVGTSISGHESQSSVPADSHTSKATSPMGITFAMGDTSVSTSTPAFFETRIQTESTSSLIPGLRDTRTSEEINTVTETSTVLSEVPTTTTTEVSRTEVITSSRTTISGPDHSKMSPYISTETITRLSTFPFVTGSTEMAITNQTGPIGTISQATLTLDTSSTASWEGTHSPVTQRFPHSEETTTMSRSTKGVSWQSPPSVEETSSPSSPVPLPAITSHSSLYSAVSGSSPTSALPVTSLLTSGRRKTIDMLDTHSELVTSSLPSASSFSGEILTSEASTNTETIHFSENTAETNMGTTNSMHKLHSSVSIHSQPSGHTPPKVTGSMMEDAIVSTSTPGSPETKNVDRDSTSPLTPELKEDSTALVMNSTTESNTVFSSVSLDAATEVSRAEVTYYDPTFMPASAQSTKSPDISPEASSSHSNSPPLTISTHKTIATQTGPSGVTSLGQLTLDTSTIATSAGTPSARTQDFVDSETTSVMNNDLNDVLKTSPFSAEEANSLSSQAPLLVTTSPSPVTSTLQEHSTSSLVSVTSVPTPTLAKITDMDTNLEPVTRSPQNLRNTLATSEATTDTHTMHPSINTAVANVGTTSSPNEFYFTVSPDSDPYKATSAVVITSTSGDSIVSTSMPRSSAMKKIESETTFSLIFRLRETSTSQKIGSSSDTSTVFDKAFTAATTEVSRTELTSSSRTSIQGTEKPTMSPDTSTRSVTMLSTFAGLTKSEERTIATQTGPHRATSQGTLTWDTSITTSQAGTHSAMTHGFSQLDLSTLTSRVPEYISGTSPPSVEKTSSSSSLLSLPAITSPSPVPTTLPESRPSSPVHLTSLPTSGLVKTTDMLASVASLPPNLGSTSHKIPTTSEDIKDTEKMYPSTNIAVTNVGTTTSEKESYSSVPAYSEPPKVTSPMVTSFNIRDTIVSTSMPGSSEITRIEMESTFSLAHGLKGTSTSQDPIVSTEKSAVLHKLTTGATETSRTEVASSRRTSIPGPDHSTESPDISTEVIPSLPISLGITESSNMTIITRTGPPLGSTSQGTFTLDTPTTSSRAGTHSMATQEFPHSEMTTVMNKDPEILSWTIPPSIEKTSFSSSLMPSPAMTSPPVSSTLPKTIHTTPSPMTSLLTPSLVMTTDTLGTSPEPTTSSPPNLSSTSHEILTTDEDTTAIEAMHPSTSTAATNVETTSSGHGSQSSVLADSEKTKATAPMDTTSTMGHTTVSTSMSVSSETTKIKRESTYSLTPGLRETSISQNASFSTDTSIVLSEVPTGTTAEVSRTEVTSSGRTSIPGPSQSTVLPEISTRTMTRLFASPTMTESAEMTIPTQTGPSGSTSQDTLTLDTSTTKSQAKTHSTLTQRFPHSEMTTLMSRGPGDMSWQSSPSLENPSSLPSLLSLPATTSPPPISSTLPVTISSSPLPVTSLLTSSPVTTTDMLHTSPELVTSSPPKLSHTSDERLTTGKDTTNTEAVHPSTNTAASNVEIPSSGHESPSSALADSETSKATSPMFITSTQEDTTVAISTPHFLETSRIQKESISSLSPKLRETGSSVETSSAIETSAVLSEVSIGATTEISRTEVTSSSRTSISGSAESTMLPEISTTRKIIKFPTSPILAESSEMTIKTQTSPPGSTSESTFTLDTSTTPSLVITHSTMTQRLPHSEITTLVSRGAGDVPRPSSLPVEETSPPSSQLSLSAMISPSPVSSTLPASSHSSSASVTSLLTPGQVKTTEVLDASAEPETSSPPSLSSTSVEILATSEVTTDTEKIHPFSNTAVTKVGTSSSGHESPSSVLPDSETTKATSAMGTISIMGDTSVSTLTPALSNTRKIQSEPASSLTTRLRETSTSEETSLATEANTVLSKVSTGATTEVSRTEAISFSRTSMSGPEQSTMSQDISIGTIPRISASSVLTESAKMTITTQTGPSESTLESTLNLNTATTPSWVETHSIVIQGFPHPEMTTSMGRGPGGVSWPSPPFVKETSPPSSPLSLPAVTSPHPVSTTFLAHIPPSPLPVTSLLTSGPATTTDILGTSTEPGTSSSSSLSTTSHERLTTYKDTAHTEAVHPSTNTGGTNVATTSSGYKSQSSVLADSSPMCTTSTMGDTSVLTSTPAFLETRRIQTELASSLTPGLRESSGSEGTSSGTKMSTVLSKVPTGATTEISKEDVTSIPGPAQSTISPDISTRTVSWFSTSPVMTESAEITMNTHTSPLGATTQGTSTLDTSSTTSLTMTHSTISQGFSHSQMSTLMRRGPEDVSWMSPPLLEKTRPSFSLMSSPATTSPSPVSSTLPESISSSPLPVTSLLTSGLAKTTDMLHKSSEPVTNSPANLSSTSVEILATSEVTTDTEKTHPSSNRTVTDVGTSSSGHESTSFVLADSQTSKVTSPMVITSTMEDTSVSTSTPGFFETSRIQTEPTSSLTLGLRKTSSSEGTSLATEMSTVLSGVPTGATAEVSRTEVTSSSRTSISGFAQLTVSPETSTETITRLPTSSIMTESAEMMIKTQTDPPGSTPESTHTVDISTTPNWVETHSTVTQRFSHSEMTTLVSRSPGDMLWPSQSSVEETSSASSLLSLPATTSPSPVSSTLVEDFPSASLPVTSLLNPGLVITTDRMGISREPGTSSTSNLSSTSHERLTTLEDTVDTEDMQPSTHTAVTNVRTSISGHESQSSVLSDSETPKATSPMGTTYTMGETSVSISTSDFFETSRIQIEPTSSLTSGLRETSSSERISSATEGSTVLSEVPSGATTEVSRTEVISSRGTSMSGPDQFTISPDISTEAITRLSTSPIMTESAESAITIETGSPGATSEGTLTLDTSTTTFWSGTHSTASPGFSHSEMTTLMSRTPGDVPWPSLPSVEEASSVSSSLSSPAMTSTSFFSTLPESISSSPHPVTALLTLGPVKTTDMLRTSSEPETSSPPNLSSTSAEILATSEVTKDREKIHPSSNTPVVNVGTVIYKHLSPSSVLADLVTTKPTSPMATTSTLGNTSVSTSTPAFPETMMTQPTSSLTSGLREISTSQETSSATERSASLSGMPTGATTKVSRTEALSLGRTSTPGPAQSTISPEISTETITRISTPLTTTGSAEMTITPKTGHSGASSQGTFTLDTSSRASWPGTHSAATHRSPHSGMTTPMSRGPEDVSWPSRPSVEKTSPPSSLVSLSAVTSPSPLYSTPSESSHSSPLRVTSLFTPVMMKTTDMLDTSLEPVTTSPPSMNITSDESLATSKATMETEAIQLSENTAVTQMGTISARQEFYSSYPGLPEPSKVTSPVVTSSTIKDIVSTTIPASSEITRIEMESTSTLTPTPRETSTSQEIHSATKPSTVPYKALTSATIEDSMTQVMSSSRGPSPDQSTMSQDISTEVITRLSTSPIKTESTEMTITTQTGSPGATSRGTLTLDTSTTFMSGTHSTASQGFSHSQMTALMSRTPGDVPWLSHPSVEEASSASFSLSSPVMTSSSPVSSTLPDSIHSSSLPVTSLLTSGLVKTTELLGTSSEPETSSPPNLSSTSAEILAITEVTTDTEKLEMTNVVTSGYTHESPSSVLADSVTTKATSSMGITYPTGDTNVLTSTPAFSDTSRIQTKSKLSLTPGLMETSISEETSSATEKSTVLSSVPTGATTEVSRTEAISSSRTSIPGPAQSTMSSDTSMETITRISTPLTRKESTDMAITPKTGPSGATSQGTFTLDSSSTASWPGTHSATTQRFPQSVVTTPMSRGPEDVSWPSPLSVEKNSPPSSLVSSSSVTSPSPLYSTPSGSSHSSPVPVTSLFTSIMMKATDMLDASLEPETTSAPNMNITSDESLAASKATTETEAIHVFENTAASHVETTSATEELYSSSPGFSEPTKVISPVVTSSSIRDNMVSTTMPGSSGITRIEIESMSSLTPGLRETRTSQDITSSTETSTVLYKMPSGATPEVSRTEVMPSSRTSIPGPAQSTMSLDISDEVVTRLSTSPIMTESAEITITTQTGYSLATSQVTLPLGTSMTFLSGTHSTMSQGLSHSEMTNLMSRGPESLSWTSPRFVETTRSSSSLTSLPLTTSLSPVSSTLLDSSPSSPLPVTSLILPGLVKTTEVLDTSSEPKTSSSPNLSSTSVEIPATSEIMTDTEKIHPSSNTAVAKVRTSSSVHESHSSVLADSETTITIPSMGITSAVDDTTVFTSNPAFSETRRIPTEPTFSLTPGFRETSTSEETTSITETSAVLYGVPTSATTEVSMTEIMSSNRIHIPDSDQSTMSPDIITEVITRLSSSSMMSESTQMTIT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Note=Detected in both cell membrane and cytoplasm in neurons. {ECO:0000250|UniProtKB:Q8R0I0}.; SUBCELLULAR LOCATION: [Isoform 2]: Apical cell membrane {ECO:0000269|PubMed:33432184}.","topological_domain":"TOPO_DOM 18..740; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 762..805; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 741..761; /note=\"Helical\"; /evidence=\"ECO:0000255|PROSITE-ProRule:PRU01354\""},"signal_peptides":[{"description":null,"end":17,"evidence":"ECO:0000255","source_location":"SIGNAL 1..17; /evidence=\"ECO:0000255\"","start":1}],"state":"available","topological_domains":[{"description":"Extracellular","end":740,"evidence":"ECO:0000255","source_location":"TOPO_DOM 18..740; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":18},{"description":"Cytoplasmic","end":805,"evidence":"ECO:0000255","source_location":"TOPO_DOM 762..805; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":762}],"transmembrane_segments":[{"description":"Helical","end":761,"evidence":"ECO:0000255|PROSITE-ProRule:PRU01354","source_location":"TRANSMEM 741..761; 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extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000142627","evidence_rank":65,"extracellular_segments":{"records":[{"basis":"reviewed-uniprot-topological-domain","end":537,"evidence_class":"source-annotated-topology","length":514,"sequence":"AQGKEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMYSVCNVMSGDQDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRKGFYLAFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGGEEPRMHCAVDGEWLVPIGQCLCQAGYEKVEDACQACSPGFFKFEASESPCLECPEHTLPSPEGATSCECEEGFFRAPQDPASMPCTRPPSAPHYLTAVGMGAKVELRWTPPQDSGGREDIVYSVTCEQCWPESGECGPCEASVRYSEPPHGLTRTSVTVSDLEPHMNYTFTVEARNGVSGLVTSRSFRTASVSINQTEPPKVRLEGRSTTSLSVSWSIPPPQQSRVWKYEVTYRKKGDSNSYNVRRTEGFSVTLDDLAPDTTYLVQVQALTQEGQGAGSKVHEFQTLSPEGSGNLAV","sequence_sha256":"895a31decb9405460cd84a84412adebeac029f89d8f9d922aff8006571b9f5e9","start":24}],"state":"source-annotated"},"gene_symbol":"EPHA2","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MELQAARACFALLWGCALAAAAAAQGKEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMYSVCNVMSGDQDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRKGFYLAFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGGEEPRMHCAVDGEWLVPIGQCLCQAGYEKVEDACQACSPGFFKFEASESPCLECPEHTLPSPEGATSCECEEGFFRAPQDPASMPCTRPPSAPHYLTAVGMGAKVELRWTPPQDSGGREDIVYSVTCEQCWPESGECGPCEASVRYSEPPHGLTRTSVTVSDLEPHMNYTFTVEARNGVSGLVTSRSFRTASVSINQTEPPKVRLEGRSTTSLSVSWSIPPPQQSRVWKYEVTYRKKGDSNSYNVRRTEGFSVTLDDLAPDTTYLVQVQALTQEGQGAGSKVHEFQTLSPEGSGNLAVIGGVAVGVVLLLVLAGVGFFIHRRRKNQRARQSPEDVYFSKSEQLKPLKTYVDPHTYEDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRLPSTSGSEGVPFRTVSEWLESIKMQQYTEHFMAAGYTAIEKVVQMTNDDIKRIGVRLPGHQKRIAYSLLGLKDQVNTVGIPI","length":976,"sha256":"29416c9490a3c35fa69a9086f09fb7c75915d5d7467cb594e5b517e8fa9f344f","state":"available"},"source_refs":[{"artifact":{"bytes":6130,"format":"json","sha256":"69344b755d3085e4ba3500b2cbfe0e0673bb33b55fdcc92d8c5dcee8d660fab4","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/P29317"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"P29317","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"structure-c","target_id":"T-ENSG00000142627","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":976},"entry_name":"EPHA2_HUMAN","gene_names":"EPHA2 ECK","lipidation_sites":[],"protein_names":"Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)","raw_fields":{"lipidation":"","signal_peptide":"SIGNAL 1..23; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18794797, ECO:0000269|PubMed:19573808, ECO:0000269|PubMed:20223987, ECO:0000269|PubMed:20861311, ECO:0000269|PubMed:34067457}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, ruffle membrane {ECO:0000269|PubMed:19573808}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:19573808}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, focal adhesion {ECO:0000269|PubMed:10655584}. Note=Present at regions of cell-cell contacts but also at the leading edge of migrating cells (PubMed:19573808, PubMed:20861311). Relocates from the plasma membrane to the cytoplasmic and perinuclear regions in cancer cells (PubMed:18794797). {ECO:0000269|PubMed:18794797, ECO:0000269|PubMed:19573808, ECO:0000269|PubMed:20861311, ECO:0000269|PubMed:26158630}.","topological_domain":"TOPO_DOM 24..537; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 559..976; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 538..558; /note=\"Helical\"; /evidence=\"ECO:0000255\""},"signal_peptides":[{"description":null,"end":23,"evidence":"ECO:0000255","source_location":"SIGNAL 1..23; /evidence=\"ECO:0000255\"","start":1}],"state":"available","topological_domains":[{"description":"Extracellular","end":537,"evidence":"ECO:0000255","source_location":"TOPO_DOM 24..537; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":24},{"description":"Cytoplasmic","end":976,"evidence":"ECO:0000255","source_location":"TOPO_DOM 559..976; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":559}],"transmembrane_segments":[{"description":"Helical","end":558,"evidence":"ECO:0000255","source_location":"TRANSMEM 538..558; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":538}]},"uniprot_accession":"P29317"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000066468","evidence_rank":66,"extracellular_segments":{"records":[{"basis":"reviewed-uniprot-topological-domain","end":377,"evidence_class":"source-annotated-topology","length":356,"sequence":"RPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLE","sequence_sha256":"a81db1dfdc69b4b2527166d330ebcb53a4495aa7a18ceafd4a96a53d5b15849c","start":22}],"state":"source-annotated"},"gene_symbol":"FGFR2","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT","length":821,"sha256":"c81b4e9e806e0ace9f779e65477e6c988dea6cad5eecfbcb35f2364c5fc884dd","state":"available"},"source_refs":[{"artifact":{"bytes":49540,"format":"json","sha256":"aa399e514589c00652f52e9352b3a77bbe9619f929be9148fde6c3b16aca8c17","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/P21802"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"P21802","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"retained-unmodeled","target_id":"T-ENSG00000066468","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":821},"entry_name":"FGFR2_HUMAN","gene_names":"FGFR2 BEK KGFR KSAM","lipidation_sites":[],"protein_names":"Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332)","raw_fields":{"lipidation":"","signal_peptide":"SIGNAL 1..21; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Golgi apparatus. Cytoplasmic vesicle. Note=Detected on osteoblast plasma membrane lipid rafts. After ligand binding, the activated receptor is rapidly internalized and degraded.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Note=After ligand binding, the activated receptor is rapidly internalized and degraded.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane; Single-pass type I membrane protein. Note=After ligand binding, the activated receptor is rapidly internalized and degraded.; SUBCELLULAR LOCATION: [Isoform 8]: Secreted.; SUBCELLULAR LOCATION: [Isoform 13]: Secreted.","topological_domain":"TOPO_DOM 22..377; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 399..821; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 378..398; /note=\"Helical\"; /evidence=\"ECO:0000255\""},"signal_peptides":[{"description":null,"end":21,"evidence":"ECO:0000255","source_location":"SIGNAL 1..21; /evidence=\"ECO:0000255\"","start":1}],"state":"available","topological_domains":[{"description":"Extracellular","end":377,"evidence":"ECO:0000255","source_location":"TOPO_DOM 22..377; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":22},{"description":"Cytoplasmic","end":821,"evidence":"ECO:0000255","source_location":"TOPO_DOM 399..821; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":399}],"transmembrane_segments":[{"description":"Helical","end":398,"evidence":"ECO:0000255","source_location":"TRANSMEM 378..398; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":378}]},"uniprot_accession":"P21802"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000137845","evidence_rank":67,"extracellular_segments":{"records":[{"basis":"reviewed-uniprot-topological-domain","end":672,"evidence_class":"source-annotated-topology","length":653,"sequence":"QYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFLRLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVIDGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKAIFSPELYENIAE","sequence_sha256":"e4400d6a6307dd5802b41fdcee2791cb772b4a00d59dc139cb3f4245eb71ea3d","start":20}],"state":"source-annotated"},"gene_symbol":"ADAM10","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFLRLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVIDGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKAIFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTLKRRRPPQPIQQPQRQRPRESYQMGHMRR","length":748,"sha256":"74a4db6b2d0c653bda0ad7877139bd95207b603f7665c60adce2ef7045bb215d","state":"available"},"source_refs":[{"artifact":{"bytes":5651,"format":"json","sha256":"5c3269549a254c25b35f09b89744ddd013c20236f735c3e075708693f19644cf","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/O14672"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"O14672","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"structure-c","target_id":"T-ENSG00000137845","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":748},"entry_name":"ADA10_HUMAN","gene_names":"ADAM10 KUZ MADM","lipidation_sites":[],"protein_names":"Disintegrin and metalloproteinase domain-containing protein 10 (ADAM 10) (EC 3.4.24.81) (CDw156) (Kuzbanian protein homolog) (Mammalian disintegrin-metalloprotease) (CD antigen CD156c)","raw_fields":{"lipidation":"","signal_peptide":"SIGNAL 1..19; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20624979, ECO:0000269|PubMed:23676497, ECO:0000269|PubMed:24990881, ECO:0000269|PubMed:26686862, ECO:0000269|PubMed:29430990, ECO:0000269|PubMed:30463011, ECO:0000269|PubMed:33731436}; Single-pass type I membrane protein {ECO:0000305}. Golgi apparatus membrane {ECO:0000269|PubMed:12475894}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:12475894}. Cell projection, axon {ECO:0000250|UniProtKB:O35598}. Cell projection, dendrite {ECO:0000250|UniProtKB:O35598}. Cell junction, adherens junction {ECO:0000269|PubMed:30463011}. Cytoplasm {ECO:0000269|PubMed:30463011}. Note=Is localized in the plasma membrane but is also expressed in the Golgi apparatus and in clathrin-coated vesicles derived likely from the Golgi (PubMed:12475894). During long term depression, it is recruited to the cell membrane by DLG1 (PubMed:23676497). The immature form is mainly located near cytoplasmic fibrillar structures, while the mature form is predominantly located at zonula adherens and the cell membrane (PubMed:30463011). 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/note=\"Helical\"; /evidence=\"ECO:0000255\"","start":525}]},"uniprot_accession":"P10721"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000007062","evidence_rank":74,"extracellular_segments":{"records":[{"basis":"reviewed-uniprot-topological-domain","end":108,"evidence_class":"source-annotated-topology","length":89,"sequence":"GGQPSSTDAPKAWNYELPATNYETQDSHKAGPIGILFELVHIFLYVVQPRDFPEDTLRKFLQKAYESKIDYDKPETVILGLKIVYYEAG","sequence_sha256":"d0af8347ce3eb22f495a95018c33885c07361a147777b81652455707c2279a69","start":20},{"basis":"reviewed-uniprot-topological-domain","end":433,"evidence_class":"source-annotated-topology","length":255,"sequence":"ANHQVRTRIKRSRKLADSNFKDLRTLLNETPEQIKYILAQYNTTKDKAFTDLNSINSVLGGGILDRLRPNIIPVLDEIKSMATAIKETKEALENMNSTLKSLHQQSTQLSSSLTSVKTSLRSSLNDPLCLVHPSSETCNSIRLSLSQLNSNPELRQLPPVDAELDNVNNVLRTDLDGLVQQGYQSLNDIPDRVQRQTTTVVAGIKRVLNSIGSDIDNVTQRLPIQDILSAFSVYVNNTESYIHRNLPTLEEYDSY","sequence_sha256":"9023775f2234eb653c2c54858c427dd4d68f6d67420a061d15a35bbf477b60b3","start":179},{"basis":"reviewed-uniprot-topological-domain","end":792,"evidence_class":"source-annotated-topology","length":285,"sequence":"GANVEKLICEPYTSKELFRVLDTPYLLNEDWEYYLSGKLFNKSKMKLTFEQVYSDCKKNRGTYGTLHLQNSFNISEHLNINEHTGSISSELESLKVNLNIFLLGAAGRKNLQDFAACGIDRMNYDSYLAQTGKSPAGVNLLSFAYDLEAKANSLPPGNLRNSLKRDAQTIKTIHQQRVLPIEQSLSTLYQSVKILQRTGNGLLERVTRILASLDFAQNFITNNTSSVIIEETKKYGRTIIGYFEHYLQWIEFSISEKVASCKPVATALDTAVDVFLCSYIIDPLN","sequence_sha256":"54e40f363cbb4e5482630c10311ad1a36192124a7f0dc53cd53d7efadc650394","start":508}],"state":"source-annotated"},"gene_symbol":"PROM1","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MALVLGSLLLLGLCGNSFSGGQPSSTDAPKAWNYELPATNYETQDSHKAGPIGILFELVHIFLYVVQPRDFPEDTLRKFLQKAYESKIDYDKPETVILGLKIVYYEAGIILCCVLGLLFIILMPLVGYFFCMCRCCNKCGGEMHQRQKENGPFLRKCFAISLLVICIIISIGIFYGFVANHQVRTRIKRSRKLADSNFKDLRTLLNETPEQIKYILAQYNTTKDKAFTDLNSINSVLGGGILDRLRPNIIPVLDEIKSMATAIKETKEALENMNSTLKSLHQQSTQLSSSLTSVKTSLRSSLNDPLCLVHPSSETCNSIRLSLSQLNSNPELRQLPPVDAELDNVNNVLRTDLDGLVQQGYQSLNDIPDRVQRQTTTVVAGIKRVLNSIGSDIDNVTQRLPIQDILSAFSVYVNNTESYIHRNLPTLEEYDSYWWLGGLVICSLLTLIVIFYYLGLLCGVCGYDRHATPTTRGCVSNTGGVFLMVGVGLSFLFCWILMIIVVLTFVFGANVEKLICEPYTSKELFRVLDTPYLLNEDWEYYLSGKLFNKSKMKLTFEQVYSDCKKNRGTYGTLHLQNSFNISEHLNINEHTGSISSELESLKVNLNIFLLGAAGRKNLQDFAACGIDRMNYDSYLAQTGKSPAGVNLLSFAYDLEAKANSLPPGNLRNSLKRDAQTIKTIHQQRVLPIEQSLSTLYQSVKILQRTGNGLLERVTRILASLDFAQNFITNNTSSVIIEETKKYGRTIIGYFEHYLQWIEFSISEKVASCKPVATALDTAVDVFLCSYIIDPLNLFWFGIGKATVFLLPALIFAVKLAKYYRRMDSEDVYDDVETIPMKNMENGNNGYHKDHVYGIHNPVMTSPSQH","length":865,"sha256":"cb68350aedcd637e801a54a16f8c205c920dcde6c9f2c595bcd4a0b56251df77","state":"available"},"source_refs":[{"artifact":{"bytes":22200,"format":"json","sha256":"e4cc5c163ebb6e08d639e09dfbb40d92b477b46ef4ae4ea50b5dacb26062d6d8","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/O43490"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"O43490","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"retained-unmodeled","target_id":"T-ENSG00000007062","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":865},"entry_name":"PROM1_HUMAN","gene_names":"PROM1 PROML1 MSTP061","lipidation_sites":[],"protein_names":"Prominin-1 (Antigen AC133) (Prominin-like protein 1) (CD antigen CD133)","raw_fields":{"lipidation":"","signal_peptide":"SIGNAL 1..19; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, microvillus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250}. Endoplasmic reticulum. Endoplasmic reticulum-Golgi intermediate compartment. Note=Found in extracellular membrane particles in various body fluids such as cerebrospinal fluid, saliva, seminal fluid and urine.","topological_domain":"TOPO_DOM 20..108; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 130..157; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 179..433; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 455..486; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 508..792; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 814..865; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 109..129; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 158..178; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 434..454; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 487..507; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 793..813; /note=\"Helical\"; /evidence=\"ECO:0000255\""},"signal_peptides":[{"description":null,"end":19,"evidence":"ECO:0000255","source_location":"SIGNAL 1..19; /evidence=\"ECO:0000255\"","start":1}],"state":"available","topological_domains":[{"description":"Extracellular","end":108,"evidence":"ECO:0000255","source_location":"TOPO_DOM 20..108; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":20},{"description":"Cytoplasmic","end":157,"evidence":"ECO:0000255","source_location":"TOPO_DOM 130..157; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":130},{"description":"Extracellular","end":433,"evidence":"ECO:0000255","source_location":"TOPO_DOM 179..433; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":179},{"description":"Cytoplasmic","end":486,"evidence":"ECO:0000255","source_location":"TOPO_DOM 455..486; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":455},{"description":"Extracellular","end":792,"evidence":"ECO:0000255","source_location":"TOPO_DOM 508..792; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":508},{"description":"Cytoplasmic","end":865,"evidence":"ECO:0000255","source_location":"TOPO_DOM 814..865; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":814}],"transmembrane_segments":[{"description":"Helical","end":129,"evidence":"ECO:0000255","source_location":"TRANSMEM 109..129; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":109},{"description":"Helical","end":178,"evidence":"ECO:0000255","source_location":"TRANSMEM 158..178; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":158},{"description":"Helical","end":454,"evidence":"ECO:0000255","source_location":"TRANSMEM 434..454; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":434},{"description":"Helical","end":507,"evidence":"ECO:0000255","source_location":"TRANSMEM 487..507; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":487},{"description":"Helical","end":813,"evidence":"ECO:0000255","source_location":"TRANSMEM 793..813; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":793}]},"uniprot_accession":"O43490"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000130300","evidence_rank":75,"extracellular_segments":{"records":[{"basis":"reviewed-uniprot-topological-domain","end":442,"evidence_class":"source-annotated-topology","length":394,"sequence":"YGNVHVSTESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASFRQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTKSQPMMPVSRPMGPVPNPQPIDPASLEEFKRKILESQRPPAGIPVAPSSG","sequence_sha256":"594e16597ef952469aee7bf88448ce7d8a87e94bc245b9c0b1caa9d0254b4e0b","start":49}],"state":"source-annotated"},"gene_symbol":"PLVAP","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MGLAMEHGGSYARAGGSSRGCWYYLRYFFLFVSLIQFLIILGLVLFMVYGNVHVSTESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASFRQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTKSQPMMPVSRPMGPVPNPQPIDPASLEEFKRKILESQRPPAGIPVAPSSG","length":442,"sha256":"2647faacd277934cdb68d42958afebf6807a736c56550a20fff607d8e730055f","state":"available"},"source_refs":[{"artifact":{"bytes":2608,"format":"json","sha256":"fd7aae354b9741ec1add5f83e09989e0b32c5b5ce2e318d336537cab07a93363","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/Q9BX97"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"Q9BX97","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"retained-unmodeled","target_id":"T-ENSG00000130300","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":442},"entry_name":"PLVAP_HUMAN","gene_names":"PLVAP FELS PV1","lipidation_sites":[],"protein_names":"Plasmalemma vesicle-associated protein (Fenestrated endothelial-linked structure protein) (Plasmalemma vesicle protein 1) (PV-1)","raw_fields":{"lipidation":"","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9WV78}; Single-pass type II membrane protein {ECO:0000255}. Membrane, caveola {ECO:0000250|UniProtKB:Q9WV78}; Single-pass type II membrane protein {ECO:0000255}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9WV78}. Note=Membrane-associated protein of caveolae. Found in fenestral and stomatal diaphragms in fenestrated endothelia and transendothelial channels. 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Apical cell membrane {ECO:0000250|UniProtKB:Q00657}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q00657}; Extracellular side {ECO:0000250|UniProtKB:Q00657}. Cell projection, lamellipodium membrane {ECO:0000250|UniProtKB:Q00657}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q00657}; Extracellular side {ECO:0000250|UniProtKB:Q00657}. Cell surface {ECO:0000250|UniProtKB:Q00657}. Note=Localized at the apical plasma membrane it relocalizes to the lamellipodia of astrocytoma upon phosphorylation by PRKCA. Localizes to the retraction fibers. 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Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:19506252}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000269|PubMed:23189181}; Multi-pass membrane protein {ECO:0000255}. Note=Enriched in membrane lipid rafts. {ECO:0000269|PubMed:28623970}.","topological_domain":"TOPO_DOM 1..395; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 417..428; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 450..477; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 499..506; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 528..535; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 557..630; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 652..655; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 396..416; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 429..449; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 478..498; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 507..527; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 536..556; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 631..651; /note=\"Helical\"; /evidence=\"ECO:0000255\""},"signal_peptides":[],"state":"available","topological_domains":[{"description":"Cytoplasmic","end":395,"evidence":"ECO:0000255","source_location":"TOPO_DOM 1..395; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":1},{"description":"Extracellular","end":428,"evidence":"ECO:0000255","source_location":"TOPO_DOM 417..428; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":417},{"description":"Cytoplasmic","end":477,"evidence":"ECO:0000255","source_location":"TOPO_DOM 450..477; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":450},{"description":"Extracellular","end":506,"evidence":"ECO:0000255","source_location":"TOPO_DOM 499..506; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":499},{"description":"Cytoplasmic","end":535,"evidence":"ECO:0000255","source_location":"TOPO_DOM 528..535; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":528},{"description":"Extracellular","end":630,"evidence":"ECO:0000255","source_location":"TOPO_DOM 557..630; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":557},{"description":"Cytoplasmic","end":655,"evidence":"ECO:0000255","source_location":"TOPO_DOM 652..655; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":652}],"transmembrane_segments":[{"description":"Helical","end":416,"evidence":"ECO:0000255","source_location":"TRANSMEM 396..416; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":396},{"description":"Helical","end":449,"evidence":"ECO:0000255","source_location":"TRANSMEM 429..449; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":429},{"description":"Helical","end":498,"evidence":"ECO:0000255","source_location":"TRANSMEM 478..498; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":478},{"description":"Helical","end":527,"evidence":"ECO:0000255","source_location":"TRANSMEM 507..527; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":507},{"description":"Helical","end":556,"evidence":"ECO:0000255","source_location":"TRANSMEM 536..556; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":536},{"description":"Helical","end":651,"evidence":"ECO:0000255","source_location":"TRANSMEM 631..651; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":631}]},"uniprot_accession":"Q9UNQ0"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000146205","evidence_rank":100,"extracellular_segments":{"records":[{"basis":"reviewed-uniprot-topological-domain","end":420,"evidence_class":"source-annotated-topology","length":44,"sequence":"SDIPTQELCGSKDSFEMCPLCLDCPFWLLSSACALAQAGRLFDH","sequence_sha256":"c2bbe1cc5d74b14421c53e21cdc774ae34b94264b7aea0e6d5894d55bd8d257e","start":377},{"basis":"reviewed-uniprot-topological-domain","end":550,"evidence_class":"source-annotated-topology","length":30,"sequence":"YRAIMAIVVSRSGNTLLAAWASRIASLTGS","sequence_sha256":"3daf6a9a2fb7d82a61f132097deadfbba19bced2fa0714615cb417443d2d95b0","start":521},{"basis":"reviewed-uniprot-topological-domain","end":714,"evidence_class":"source-annotated-topology","length":105,"sequence":"KGRFVGYPGNYHTLFGVRNEECAAGGCLIELAQELLVIMVGKQVINNMQEVLIPKLKGWWQKFRLRSKKRKAGASAGASQGPWEDDYELVPCEGLFDEYLEMVLQ","sequence_sha256":"cbe2a93bb712ed105bb47b31b7b86448c13e1812f6da88538bfc0e4a2450bb3c","start":610},{"basis":"reviewed-uniprot-topological-domain","end":843,"evidence_class":"source-annotated-topology","length":59,"sequence":"AFSSDFLPRAYYRWTRAHDLRGFLNFTLARAPSSFAAAHNRTCRYRAFRDDDGHYSQTY","sequence_sha256":"80ffc1b1916f3bf46b9284400a9e81af024c7ba069190ee96a14d5356fb1e85e","start":785}],"state":"source-annotated"},"gene_symbol":"ANO7","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MRMAATAWAGLQGPPLPTLCPAVRTGLYCRDQAHAERWAMTSETSSGSHCARSRMLRRRAQEEDSTVLIDVSPPEAEKRGSYGSTAHASEPGGQQAAACRAGSPAKPRIADFVLVWEEDLKLDRQQDSAARDRTDMHRTWRETFLDNLRAAGLCVDQQDVQDGNTTVHYALLSASWAVLCYYAEDLRLKLPLQELPNQASNWSAGLLAWLGIPNVLLEVVPDVPPEYYSCRFRVNKLPRFLGSDNQDTFFTSTKRHQILFEILAKTPYGHEKKNLLGIHQLLAEGVLSAAFPLHDGPFKTPPEGPQAPRLNQRQVLFQHWARWGKWNKYQPLDHVRRYFGEKVALYFAWLGFYTGWLLPAAVVGTLVFLVGCFLVFSDIPTQELCGSKDSFEMCPLCLDCPFWLLSSACALAQAGRLFDHGGTVFFSLFMALWAVLLLEYWKRKSATLAYRWDCSDYEDTEERPRPQFAASAPMTAPNPITGEDEPYFPERSRARRMLAGSVVIVVMVAVVVMCLVSIILYRAIMAIVVSRSGNTLLAAWASRIASLTGSVVNLVFILILSKIYVSLAHVLTRWEMHRTQTKFEDAFTLKVFIFQFVNFYSSPVYIAFFKGRFVGYPGNYHTLFGVRNEECAAGGCLIELAQELLVIMVGKQVINNMQEVLIPKLKGWWQKFRLRSKKRKAGASAGASQGPWEDDYELVPCEGLFDEYLEMVLQFGFVTIFVAACPLAPLFALLNNWVEIRLDARKFVCEYRRPVAERAQDIGIWFHILAGLTHLAVISNAFLLAFSSDFLPRAYYRWTRAHDLRGFLNFTLARAPSSFAAAHNRTCRYRAFRDDDGHYSQTYWNLLAIRLAFVIVFEHVVFSVGRLLDLLVPDIPESVEIKVKREYYLAKQALAENEVLFGTNGTKDEQPEGSELSSHWTPFTVPKASQLQQ","length":933,"sha256":"e8316f260f3fa1cd475aa83846d041ba6f3541efd51176f4ddd70340d38bd074","state":"available"},"source_refs":[{"artifact":{"bytes":8592,"format":"json","sha256":"b49c4018f61ffff797bc800a4751e0ee24c3ba7eea91b69af2dbfd54d8af3257","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/Q6IWH7"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"Q6IWH7","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"retained-unmodeled","target_id":"T-ENSG00000146205","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":933},"entry_name":"ANO7_HUMAN","gene_names":"ANO7 NGEP PCANAP5 TMEM16G","lipidation_sites":[],"protein_names":"Anoctamin-7 (Dresden transmembrane protein of the prostate) (D-TMPP) (IPCA-5) (New gene expressed in prostate) (Prostate cancer-associated protein 5) (Transmembrane protein 16G)","raw_fields":{"lipidation":"","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:14981236, ECO:0000269|PubMed:17308099, ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:22946059}; Multi-pass membrane protein {ECO:0000255}. Cell junction {ECO:0000269|PubMed:17308099}. Endoplasmic reticulum {ECO:0000269|PubMed:22075693}. Note=Concentrates at sites of cell-cell contact (PubMed:17308099). Shows an intracellular localization according to PubMed:22075693 and PubMed:20056604. {ECO:0000269|PubMed:17308099, ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:22075693}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytosol {ECO:0000269|PubMed:14981236}.","topological_domain":"TOPO_DOM 1..355; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 377..420; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 442..499; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 521..550; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 572..588; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 610..714; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 736..763; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 785..843; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 865..933; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 356..376; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 421..441; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 500..520; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 551..571; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 589..609; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 715..735; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 764..784; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 844..864; /note=\"Helical\"; /evidence=\"ECO:0000255\""},"signal_peptides":[],"state":"available","topological_domains":[{"description":"Cytoplasmic","end":355,"evidence":"ECO:0000255","source_location":"TOPO_DOM 1..355; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":1},{"description":"Extracellular","end":420,"evidence":"ECO:0000255","source_location":"TOPO_DOM 377..420; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":377},{"description":"Cytoplasmic","end":499,"evidence":"ECO:0000255","source_location":"TOPO_DOM 442..499; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":442},{"description":"Extracellular","end":550,"evidence":"ECO:0000255","source_location":"TOPO_DOM 521..550; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":521},{"description":"Cytoplasmic","end":588,"evidence":"ECO:0000255","source_location":"TOPO_DOM 572..588; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":572},{"description":"Extracellular","end":714,"evidence":"ECO:0000255","source_location":"TOPO_DOM 610..714; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":610},{"description":"Cytoplasmic","end":763,"evidence":"ECO:0000255","source_location":"TOPO_DOM 736..763; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":736},{"description":"Extracellular","end":843,"evidence":"ECO:0000255","source_location":"TOPO_DOM 785..843; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":785},{"description":"Cytoplasmic","end":933,"evidence":"ECO:0000255","source_location":"TOPO_DOM 865..933; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":865}],"transmembrane_segments":[{"description":"Helical","end":376,"evidence":"ECO:0000255","source_location":"TRANSMEM 356..376; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":356},{"description":"Helical","end":441,"evidence":"ECO:0000255","source_location":"TRANSMEM 421..441; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":421},{"description":"Helical","end":520,"evidence":"ECO:0000255","source_location":"TRANSMEM 500..520; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":500},{"description":"Helical","end":571,"evidence":"ECO:0000255","source_location":"TRANSMEM 551..571; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":551},{"description":"Helical","end":609,"evidence":"ECO:0000255","source_location":"TRANSMEM 589..609; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":589},{"description":"Helical","end":735,"evidence":"ECO:0000255","source_location":"TRANSMEM 715..735; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":715},{"description":"Helical","end":784,"evidence":"ECO:0000255","source_location":"TRANSMEM 764..784; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":764},{"description":"Helical","end":864,"evidence":"ECO:0000255","source_location":"TRANSMEM 844..864; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":844}]},"uniprot_accession":"Q6IWH7"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000062038","evidence_rank":101,"extracellular_segments":{"records":[{"basis":"reviewed-uniprot-topological-domain","end":654,"evidence_class":"source-annotated-topology","length":547,"sequence":"DWVVAPISVPENGKGPFPQRLNQLKSNKDRDTKIFYSITGPGADSPPEGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSENGASVEDPMNISIIVTDQNDHKPKFTQDTFRGSVLEGVLPGTSVMQVTATDEDDAIYTYNGVVAYSIHSQEPKDPHDLMFTIHRSTGTISVISSGLDREKVPEYTLTIQATDMDGDGSTTTAVAVVEILDANDNAPMFDPQKYEAHVPENAVGHEVQRLTVTDLDAPNSPAWRATYLIMGGDDGDHFTITTHPESNQGILTTRKGLDFEAKNQHTLYVEVTNEAPFVLKLPTSTATIVVHVEDVNEAPVFVPPSKVVEVQEGIPTGEPVCVYTAEDPDKENQKISYRILRDPAGWLAMDPDSGQVTAVGTLDREDEQFVRNNIYEVMVLAMDNGSPPTTGTGTLLLTLIDVNDHGPVPEPRQITICNQSPVRQVLNITDKDLSPHTSPFQAQLTDDSDIYWTAEVNEEGDTVVLSLKKFLKQDTYDVHLSLSDHGNKEQLTVIRATVCDCHGHVETCPGPWKGG","sequence_sha256":"3bf878ac541e9c632a2fb477479c7ea1bb92cab5d89777e9533f45d0496d1361","start":108}],"state":"source-annotated"},"gene_symbol":"CDH3","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MGLPRGPLASLLLLQVCWLQCAASEPCRAVFREAEVTLEAGGAEQEPGQALGKVFMGCPGQEPALFSTDNDDFTVRNGETVQERRSLKERNPLKIFPSKRILRRHKRDWVVAPISVPENGKGPFPQRLNQLKSNKDRDTKIFYSITGPGADSPPEGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSENGASVEDPMNISIIVTDQNDHKPKFTQDTFRGSVLEGVLPGTSVMQVTATDEDDAIYTYNGVVAYSIHSQEPKDPHDLMFTIHRSTGTISVISSGLDREKVPEYTLTIQATDMDGDGSTTTAVAVVEILDANDNAPMFDPQKYEAHVPENAVGHEVQRLTVTDLDAPNSPAWRATYLIMGGDDGDHFTITTHPESNQGILTTRKGLDFEAKNQHTLYVEVTNEAPFVLKLPTSTATIVVHVEDVNEAPVFVPPSKVVEVQEGIPTGEPVCVYTAEDPDKENQKISYRILRDPAGWLAMDPDSGQVTAVGTLDREDEQFVRNNIYEVMVLAMDNGSPPTTGTGTLLLTLIDVNDHGPVPEPRQITICNQSPVRQVLNITDKDLSPHTSPFQAQLTDDSDIYWTAEVNEEGDTVVLSLKKFLKQDTYDVHLSLSDHGNKEQLTVIRATVCDCHGHVETCPGPWKGGFILPVLGAVLALLFLLLVLLLLVRKKRKIKEPLLLPEDDTRDNVFYYGEEGGGEEDQDYDITQLHRGLEARPEVVLRNDVAPTIIPTPMYRPRPANPDEIGNFIIENLKAANTDPTAPPYDTLLVFDYEGSGSDAASLSSLTSSASDQDQDYDYLNEWGSRFKKLADMYGGGEDD","length":829,"sha256":"2469935445ed65fca853e5f1237c7280a339fe2cc5d90f6b0f1ca319d21dff48","state":"available"},"source_refs":[{"artifact":{"bytes":6374,"format":"json","sha256":"40b9f4fa3f01a10557612e583bae27ed24c63f63a7e067c906129831ec58a675","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/P22223"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"P22223","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"retained-unmodeled","target_id":"T-ENSG00000062038","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":829},"entry_name":"CADH3_HUMAN","gene_names":"CDH3 CDHP","lipidation_sites":[],"protein_names":"Cadherin-3 (Placental cadherin) (P-cadherin)","raw_fields":{"lipidation":"","signal_peptide":"SIGNAL 1..24; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.","topological_domain":"TOPO_DOM 108..654; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 678..829; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 655..677; /note=\"Helical\"; /evidence=\"ECO:0000255\""},"signal_peptides":[{"description":null,"end":24,"evidence":"ECO:0000255","source_location":"SIGNAL 1..24; /evidence=\"ECO:0000255\"","start":1}],"state":"available","topological_domains":[{"description":"Extracellular","end":654,"evidence":"ECO:0000255","source_location":"TOPO_DOM 108..654; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":108},{"description":"Cytoplasmic","end":829,"evidence":"ECO:0000255","source_location":"TOPO_DOM 678..829; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":678}],"transmembrane_segments":[{"description":"Helical","end":677,"evidence":"ECO:0000255","source_location":"TRANSMEM 655..677; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":655}]},"uniprot_accession":"P22223"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000066405","evidence_rank":102,"extracellular_segments":{"records":[{"basis":"reviewed-uniprot-topological-domain","end":80,"evidence_class":"source-annotated-topology","length":53,"sequence":"DMWSTQDLYDNPVTSVFQYEGLWRSCVRQSSGFTECRPYFTILGLPAMLQAVR","sequence_sha256":"2cfa4c45314f72356b167e6363926e4d023594dce5b50b583851a12d379aa8f6","start":28},{"basis":"reviewed-uniprot-topological-domain","end":174,"evidence_class":"source-annotated-topology","length":31,"sequence":"VTNFWMSTANMYTGMGGMVQTVQTRYTFGAA","sequence_sha256":"f232105a166d351c3055d9d9ed6ef1b704984bb4001cdea111c93097b02f7c92","start":144}],"state":"source-annotated"},"gene_symbol":"CLDN18","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MSTTTCQVVAFLLSILGLAGCIAATGMDMWSTQDLYDNPVTSVFQYEGLWRSCVRQSSGFTECRPYFTILGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKIYDGGARTEDEVQSYPSKHDYV","length":261,"sha256":"89c388e151022937dd56f7be9599e2f03f07e579e7c1308d4112f0c386b1491c","state":"available"},"source_refs":[{"artifact":{"bytes":4197,"format":"json","sha256":"fb8a96b9e46008b665ddb1166aaf45314aeb847df7bfc131dfd0a27aab4b8df4","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/P56856"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"P56856","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"structure-c","target_id":"T-ENSG00000066405","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":261},"entry_name":"CLD18_HUMAN","gene_names":"CLDN18 UNQ778/PRO1572","lipidation_sites":[],"protein_names":"Claudin-18","raw_fields":{"lipidation":"","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000250|UniProtKB:P56857}. Cell membrane {ECO:0000250|UniProtKB:P56857}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to tight junctions in epithelial cells. {ECO:0000250|UniProtKB:P56857}.; SUBCELLULAR LOCATION: [Isoform A1]: Cell junction, tight junction {ECO:0000250|UniProtKB:P56857}.; SUBCELLULAR LOCATION: [Isoform A2]: Cell junction, tight junction {ECO:0000250|UniProtKB:P56857}. 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Its interaction with CAV1 is necessary for its translocation to membrane rafts (PubMed:17287217). Colocalized with PTPRC in membrane rafts (PubMed:12676959). Colocalized with FAP in invadopodia and lamellipodia of migratory activated endothelial cells in collagenous matrix. Colocalized with FAP on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma (PubMed:16651416). Colocalized with ADA at the cell junction in lymphocyte-epithelial cell adhesion (PubMed:11772392). Colocalized with IGF2R in internalized cytoplasmic vesicles adjacent to the cell surface (PubMed:10900005). {ECO:0000269|PubMed:10900005, ECO:0000269|PubMed:11772392, ECO:0000269|PubMed:11773049, ECO:0000269|PubMed:12676959, ECO:0000269|PubMed:16651416, ECO:0000269|PubMed:17287217}.","topological_domain":"TOPO_DOM 1..6; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 29..766; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 7..28; /note=\"Helical; Signal-anchor for type II membrane protein\"; /evidence=\"ECO:0000255\""},"signal_peptides":[],"state":"available","topological_domains":[{"description":"Cytoplasmic","end":6,"evidence":"ECO:0000255","source_location":"TOPO_DOM 1..6; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":1},{"description":"Extracellular","end":766,"evidence":"ECO:0000255","source_location":"TOPO_DOM 29..766; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":29}],"transmembrane_segments":[{"description":"Helical; Signal-anchor for type II membrane protein","end":28,"evidence":"ECO:0000255","source_location":"TRANSMEM 7..28; /note=\"Helical; Signal-anchor for type II membrane protein\"; /evidence=\"ECO:0000255\"","start":7}]},"uniprot_accession":"P27487"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000171124","evidence_rank":104,"extracellular_segments":{"records":[],"state":"not-explicitly-annotated"},"gene_symbol":"FUT3","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MDPLGAAKPQWPWRRCLAALLFQLLVAVCFFSYLRVSRDDATGSPRAPSGSSRQDTTPTRPTLLILLRTWPFHIPVALSRCSEMVPGTADCHITADRKVYPQADMVIVHHWDIMSNPKSRLPPSPRPQGQRWIWFNLEPPPNCQHLEALDRYFNLTMSYRSDSDIFTPYGWLEPWSGQPAHPPLNLSAKTELVAWAVSNWKPDSARVRYYQSLQAHLKVDVYGRSHKPLPKGTMMETLSRYKFYLAFENSLHPDYITEKLWRNALEAWAVPVVLGPSRSNYERFLPPDAFIHVDDFQSPKDLARYLQELDKDHARYLSYFRWRETLRPRSFSWALDFCKACWKLQQESRYQTVRSIAAWFT","length":361,"sha256":"b61c11011f05f674924fd36208448ef5cb1b06449508241cff49916b813ecf0b","state":"available"},"source_refs":[{"artifact":{"bytes":2473,"format":"json","sha256":"58e92cac1f04f358b6996e3a213fcbb5c7e14cd38e257a4394d3a5d13f1e7fe7","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/P21217"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"P21217","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"retained-unmodeled","target_id":"T-ENSG00000171124","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":361},"entry_name":"FUT3_HUMAN","gene_names":"FUT3 FT3B LE","lipidation_sites":[],"protein_names":"3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3 (EC 2.4.1.65) (4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase) (EC 2.4.1.152) (Alpha-3-fucosyltransferase FUT3) (EC 2.4.1.-) (Blood group Lewis alpha-4-fucosyltransferase) (Lewis FT) (Fucosyltransferase 3) (Fucosyltransferase III) (FucT-III)","raw_fields":{"lipidation":"","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein {ECO:0000269|PubMed:1977660}. 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/evidence=\"ECO:0000255\"; TRANSMEM 683..703; /note=\"Helical; Name=4\"; /evidence=\"ECO:0000255\"; TRANSMEM 723..743; /note=\"Helical; Name=5\"; /evidence=\"ECO:0000255\"; TRANSMEM 768..788; /note=\"Helical; Name=6\"; /evidence=\"ECO:0000255\"; TRANSMEM 803..823; /note=\"Helical; Name=7\"; /evidence=\"ECO:0000255\""},"signal_peptides":[{"description":null,"end":21,"evidence":"ECO:0000255","source_location":"SIGNAL 1..21; /evidence=\"ECO:0000255\"","start":1}],"state":"available","topological_domains":[{"description":"Extracellular","end":561,"evidence":"ECO:0000255","source_location":"TOPO_DOM 22..561; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":22},{"description":"Cytoplasmic","end":593,"evidence":"ECO:0000255","source_location":"TOPO_DOM 583..593; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":583},{"description":"Extracellular","end":638,"evidence":"ECO:0000255","source_location":"TOPO_DOM 615..638; /note=\"Extracellular\"; 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/note=\"Helical; Name=1\"; /evidence=\"ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425\"","start":37},{"description":"Helical; Name=2","end":96,"evidence":"ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425","source_location":"TRANSMEM 74..96; /note=\"Helical; Name=2\"; /evidence=\"ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425\"","start":74},{"description":"Helical; Name=3","end":133,"evidence":"ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425","source_location":"TRANSMEM 111..133; /note=\"Helical; Name=3\"; /evidence=\"ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425\"","start":111},{"description":"Helical; Name=4","end":173,"evidence":"ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425","source_location":"TRANSMEM 153..173; /note=\"Helical; Name=4\"; /evidence=\"ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425\"","start":153},{"description":"Helical; Name=5","end":224,"evidence":"ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425","source_location":"TRANSMEM 203..224; /note=\"Helical; Name=5\"; /evidence=\"ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425\"","start":203},{"description":"Helical; Name=6","end":274,"evidence":"ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425","source_location":"TRANSMEM 253..274; /note=\"Helical; Name=6\"; /evidence=\"ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425\"","start":253},{"description":"Helical; Name=7","end":309,"evidence":"ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425","source_location":"TRANSMEM 285..309; /note=\"Helical; Name=7\"; /evidence=\"ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425\"","start":285}]},"uniprot_accession":"P08100"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000106991","evidence_rank":146,"extracellular_segments":{"records":[{"basis":"reviewed-uniprot-topological-domain","end":586,"evidence_class":"source-annotated-topology","length":561,"sequence":"ETVHCDLQPVGPERGEVTYTTSQVSKGCVAQAPNAILEVHVLFLEFPTGPSQLELTLQASKQNGTWPREVLLVLSVNSSVFLHLQALGIPLHLAYNSSLVTFQEPPGVNTTELPSFPKTQILEWAAERGPITSAAELNDPQSILLRLGQAQGSLSFCMLEASQDMGRTLEWRPRTPALVRGCHLEGVAGHKEAHILRVLPGHSAGPRTVTVKVELSCAPGDLDAVLILQGPPYVSWLIDANHNMQIWTTGEYSFKIFPEKNIRGFKLPDTPQGLLGEARMLNASIVASFVELPLASIVSLHASSCGGRLQTSPAPIQTTPPKDTCSPELLMSLIQTKCADDAMTLVLKKELVAHLKCTITGLTFWDPSCEAEDRGDKFVLRSAYSSCGMQVSASMISNEAVVNILSSSSPQRKKVHCLNMDSLSFQLGLYLSPHFLQASNTIEPGQQSFVQVRVSPSVSEFLLQLDSCHLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGDPRFSFLLHFYTVPIPKTGTLSCTVALRPKTGSQDQEVHRTVFMRLNIISPDLSGCTSKG","sequence_sha256":"4e26520ec188e0b55ce5e09e8cc77b5551ec3fc672b8f8e5ac55e78484b0cda1","start":26}],"state":"source-annotated"},"gene_symbol":"ENG","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MDRGTLPLAVALLLASCSLSPTSLAETVHCDLQPVGPERGEVTYTTSQVSKGCVAQAPNAILEVHVLFLEFPTGPSQLELTLQASKQNGTWPREVLLVLSVNSSVFLHLQALGIPLHLAYNSSLVTFQEPPGVNTTELPSFPKTQILEWAAERGPITSAAELNDPQSILLRLGQAQGSLSFCMLEASQDMGRTLEWRPRTPALVRGCHLEGVAGHKEAHILRVLPGHSAGPRTVTVKVELSCAPGDLDAVLILQGPPYVSWLIDANHNMQIWTTGEYSFKIFPEKNIRGFKLPDTPQGLLGEARMLNASIVASFVELPLASIVSLHASSCGGRLQTSPAPIQTTPPKDTCSPELLMSLIQTKCADDAMTLVLKKELVAHLKCTITGLTFWDPSCEAEDRGDKFVLRSAYSSCGMQVSASMISNEAVVNILSSSSPQRKKVHCLNMDSLSFQLGLYLSPHFLQASNTIEPGQQSFVQVRVSPSVSEFLLQLDSCHLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGDPRFSFLLHFYTVPIPKTGTLSCTVALRPKTGSQDQEVHRTVFMRLNIISPDLSGCTSKGLVLPAVLGITFGAFLIGALLTAALWYIYSHTRSPSKREPVVAVAAPASSESSSTNHSIGSTQSTPCSTSSMA","length":658,"sha256":"9d83bcc4b07c00cde894c5077339d6e62f4ef394c3339ce76380957cc320da13","state":"available"},"source_refs":[{"artifact":{"bytes":5707,"format":"json","sha256":"4ec03924dd47a99e3f82fc6be020b14239d385621b38e66b1b9c03e3470537ab","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/P17813"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"P17813","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"structure-c","target_id":"T-ENSG00000106991","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":658},"entry_name":"EGLN_HUMAN","gene_names":"ENG END","lipidation_sites":[],"protein_names":"Endoglin (CD antigen CD105)","raw_fields":{"lipidation":"","signal_peptide":"SIGNAL 1..25; /evidence=\"ECO:0000269|PubMed:1692830\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10545596, ECO:0000269|PubMed:1326540, ECO:0000269|PubMed:1692830, ECO:0000269|PubMed:17540773, ECO:0000269|PubMed:8370410}; Single-pass type I membrane protein {ECO:0000305|PubMed:1692830, ECO:0000305|PubMed:8370410}.","topological_domain":"TOPO_DOM 26..586; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 612..658; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 587..611; /note=\"Helical\"; /evidence=\"ECO:0000255\""},"signal_peptides":[{"description":null,"end":25,"evidence":"ECO:0000269|PubMed:1692830","source_location":"SIGNAL 1..25; /evidence=\"ECO:0000269|PubMed:1692830\"","start":1}],"state":"available","topological_domains":[{"description":"Extracellular","end":586,"evidence":"ECO:0000255","source_location":"TOPO_DOM 26..586; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":26},{"description":"Cytoplasmic","end":658,"evidence":"ECO:0000255","source_location":"TOPO_DOM 612..658; 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/evidence=\"ECO:0000269|PubMed:15340161\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.","topological_domain":"TOPO_DOM 27..529; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 551..685; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 530..550; /note=\"Helical\"; /evidence=\"ECO:0000255\""},"signal_peptides":[{"description":null,"end":26,"evidence":"ECO:0000269|PubMed:15340161","source_location":"SIGNAL 1..26; /evidence=\"ECO:0000269|PubMed:15340161\"","start":1}],"state":"available","topological_domains":[{"description":"Extracellular","end":529,"evidence":"ECO:0000255","source_location":"TOPO_DOM 27..529; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":27},{"description":"Cytoplasmic","end":685,"evidence":"ECO:0000255","source_location":"TOPO_DOM 551..685; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":551}],"transmembrane_segments":[{"description":"Helical","end":550,"evidence":"ECO:0000255","source_location":"TRANSMEM 530..550; 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Cell junction {ECO:0000269|PubMed:20837484}. Note=Colocalizes with MMP14 at cell junctions. Also localizes at the leading edge of migrating cells. {ECO:0000269|PubMed:20837484}.","topological_domain":"TOPO_DOM 31..704; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 726..1070; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 705..725; /note=\"Helical\"; /evidence=\"ECO:0000255\""},"signal_peptides":[{"description":null,"end":30,"evidence":"ECO:0000255","source_location":"SIGNAL 1..30; /evidence=\"ECO:0000255\"","start":1}],"state":"available","topological_domains":[{"description":"Extracellular","end":704,"evidence":"ECO:0000255","source_location":"TOPO_DOM 31..704; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":31},{"description":"Cytoplasmic","end":1070,"evidence":"ECO:0000255","source_location":"TOPO_DOM 726..1070; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":726}],"transmembrane_segments":[{"description":"Helical","end":725,"evidence":"ECO:0000255","source_location":"TRANSMEM 705..725; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":705}]},"uniprot_accession":"Q13308"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000169604","evidence_rank":149,"extracellular_segments":{"records":[{"basis":"reviewed-uniprot-topological-domain","end":321,"evidence_class":"source-annotated-topology","length":289,"sequence":"EDGGPACYGGFDLYFILDKSGSVLHHWNEIYYFVEQLAHKFISPQLRMSFIVFSTRGTTLMKLTEDREQIRQGLEELQKVLPGGDTYMHEGFERASEQIYYENRQGYRTASVIIALTDGELHEDLFFYSEREANRSRDLGAIVYCVGVKDFNETQLARIADSKDHVFPVNDGFQALQGIIHSILKKSCIEILAAEPSTICAGESFQVVVRGNGFRHARNVDRVLCSFKINDSVTLNEKPFSVEDTYLLCPAPILKEVGMKAALQVSMNDGLSFISSSVIITTTHCSDGS","sequence_sha256":"3cb9e92a8ef9e54e7bb21666e64c1456f8697a6ae306ea54f8f0b0d8400c16e1","start":33}],"state":"source-annotated"},"gene_symbol":"ANTXR1","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MATAERRALGIGFQWLSLATLVLICAGQGGRREDGGPACYGGFDLYFILDKSGSVLHHWNEIYYFVEQLAHKFISPQLRMSFIVFSTRGTTLMKLTEDREQIRQGLEELQKVLPGGDTYMHEGFERASEQIYYENRQGYRTASVIIALTDGELHEDLFFYSEREANRSRDLGAIVYCVGVKDFNETQLARIADSKDHVFPVNDGFQALQGIIHSILKKSCIEILAAEPSTICAGESFQVVVRGNGFRHARNVDRVLCSFKINDSVTLNEKPFSVEDTYLLCPAPILKEVGMKAALQVSMNDGLSFISSSVIITTTHCSDGSILAIALLILFLLLALALLWWFWPLCCTVIIKEVPPPPAEESEEEDDDGLPKKKWPTVDASYYGGRGVGGIKRMEVRWGEKGSTEEGAKLEKAKNARVKMPEQEYEFPEPRNLNNNMRRPSSPRKWYSPIKGKLDALWVLLRKGYDRVSVMRPQPGDTGRCINFTRVKNNQPAKYPLNNAYHTSSPPPAPIYTPPPPAPHCPPPPPSAPTPPIPSPPSTLPPPPQAPPPNRAPPPSRPPPRPSV","length":564,"sha256":"cd36e0becd7cef67ed39ad1f6b614146a90737cff00d7fae025827a63b65e2ed","state":"available"},"source_refs":[{"artifact":{"bytes":13969,"format":"json","sha256":"2be54313bad02d11efc4af9e0f4748a08e6ad8307456e47a8b5464aae9a04d7d","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/Q9H6X2"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"Q9H6X2","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"structure-c","target_id":"T-ENSG00000169604","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":564},"entry_name":"ANTR1_HUMAN","gene_names":"ANTXR1 ATR TEM8","lipidation_sites":[],"protein_names":"Anthrax toxin receptor 1 (Tumor endothelial marker 8)","raw_fields":{"lipidation":"","signal_peptide":"SIGNAL 1..32; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16762926, ECO:0000269|PubMed:30241478}; Single-pass type I membrane protein {ECO:0000269|PubMed:16762926}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:16762926}; Single-pass type I membrane protein {ECO:0000269|PubMed:16762926}. Cell projection, filopodium membrane {ECO:0000269|PubMed:16762926}; Single-pass type I membrane protein {ECO:0000269|PubMed:16762926}. Note=At the membrane of lamellipodia and at the tip of actin-enriched filopodia (PubMed:16762926). Colocalizes with actin at the base of lamellipodia (PubMed:16762926). {ECO:0000269|PubMed:16762926}.","topological_domain":"TOPO_DOM 33..321; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 343..564; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 322..342; /note=\"Helical\"; /evidence=\"ECO:0000255\""},"signal_peptides":[{"description":null,"end":32,"evidence":"ECO:0000255","source_location":"SIGNAL 1..32; /evidence=\"ECO:0000255\"","start":1}],"state":"available","topological_domains":[{"description":"Extracellular","end":321,"evidence":"ECO:0000255","source_location":"TOPO_DOM 33..321; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":33},{"description":"Cytoplasmic","end":564,"evidence":"ECO:0000255","source_location":"TOPO_DOM 343..564; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":343}],"transmembrane_segments":[{"description":"Helical","end":342,"evidence":"ECO:0000255","source_location":"TRANSMEM 322..342; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":322}]},"uniprot_accession":"Q9H6X2"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000078098","evidence_rank":150,"extracellular_segments":{"records":[{"basis":"reviewed-uniprot-topological-domain","end":760,"evidence_class":"source-annotated-topology","length":735,"sequence":"LRPSRVHNSEENTMRALTLKDILNGTFSYKTFFPNWISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGDEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVGPQEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHIEESRTGWAGGFFVSTPVFSYDAISYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRVTQDSLFYSSNEFEEYPGRRNIYRISIGSYPPSKKCVTCHLRKERCQYYTASFSDYAKYYALVCYGPGIPISTLHDGRTDQEIKILEENKELENALKNIQLPKEEIKKLEVDEITLWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVYTERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTHFLKQCFSLSD","sequence_sha256":"8a73e2ecfae3560153da161736dc9f14bd86bbfa1301bf3bb006ea38a2e844ac","start":26}],"state":"source-annotated"},"gene_symbol":"FAP","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MKTWVKIVFGVATSAVLALLVMCIVLRPSRVHNSEENTMRALTLKDILNGTFSYKTFFPNWISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGDEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVGPQEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHIEESRTGWAGGFFVSTPVFSYDAISYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRVTQDSLFYSSNEFEEYPGRRNIYRISIGSYPPSKKCVTCHLRKERCQYYTASFSDYAKYYALVCYGPGIPISTLHDGRTDQEIKILEENKELENALKNIQLPKEEIKKLEVDEITLWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVYTERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTHFLKQCFSLSD","length":760,"sha256":"fc502b7363283bca3ea0e276ed1d65d0ae8d5064519a226a06f9c77059235b6f","state":"available"},"source_refs":[{"artifact":{"bytes":5169,"format":"json","sha256":"ddcb0dcadbf42524358f1646b38e750c309cd7eb7943aa2fd3ccd90159a181e1","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/Q12884"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"Q12884","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"structure-a","target_id":"T-ENSG00000078098","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":760},"entry_name":"SEPR_HUMAN","gene_names":"FAP","lipidation_sites":[],"protein_names":"Prolyl endopeptidase FAP (EC 3.4.21.26) (170 kDa melanoma membrane-bound gelatinase) (Dipeptidyl peptidase FAP) (EC 3.4.14.5) (Fibroblast activation protein alpha) (FAPalpha) (Gelatine degradation protease FAP) (EC 3.4.21.-) (Integral membrane serine protease) (Post-proline cleaving enzyme) (Serine integral membrane protease) (SIMP) (Surface-expressed protease) (Seprase) [Cleaved into: Antiplasmin-cleaving enzyme FAP, soluble form (APCE) (EC 3.4.14.5) (EC 3.4.21.-) (EC 3.4.21.26)]","raw_fields":{"lipidation":"","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: [Prolyl endopeptidase FAP]: Cell surface {ECO:0000269|PubMed:10593948, ECO:0000269|PubMed:16175601, ECO:0000269|PubMed:17105646, ECO:0000269|PubMed:24717288, ECO:0000269|PubMed:7911242}. Cell membrane {ECO:0000269|PubMed:12376466, ECO:0000269|PubMed:16651416, ECO:0000269|PubMed:9065413, ECO:0000303|PubMed:10455171}; Single-pass type II membrane protein {ECO:0000255}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:16651416, ECO:0000269|PubMed:9065413}; Single-pass type II membrane protein {ECO:0000255}. Cell projection, invadopodium membrane {ECO:0000269|PubMed:12376466, ECO:0000269|PubMed:16651416, ECO:0000269|PubMed:7923219, ECO:0000269|PubMed:9065413, ECO:0000303|PubMed:10455171}; Single-pass type II membrane protein {ECO:0000255}. Cell projection, ruffle membrane {ECO:0000303|PubMed:10455171}; Single-pass type II membrane protein {ECO:0000255}. Membrane {ECO:0000269|PubMed:2172980}; Single-pass type II membrane protein {ECO:0000255}. Note=Localized on cell surface with lamellipodia and invadopodia membranes and on shed vesicles. Colocalized with DPP4 at invadopodia and lamellipodia membranes of migratory activated endothelial cells in collagenous matrix. Colocalized with DPP4 on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma. Anchored and enriched preferentially by integrin alpha-3/beta-1 at invadopodia, plasma membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner. Localized at plasma and ruffle membranes in a collagen-independent manner. Colocalized with PLAUR preferentially at the cell surface of invadopodia membranes in a cytoskeleton-, integrin- and vitronectin-dependent manner. Concentrated at invadopodia membranes, specialized protrusions of the ventral plasma membrane in a fibrobectin-dependent manner. Colocalizes with extracellular components (ECM), such as collagen fibers and fibronectin. {ECO:0000269|PubMed:10593948, ECO:0000269|PubMed:12376466, ECO:0000269|PubMed:16175601, ECO:0000269|PubMed:16651416, ECO:0000269|PubMed:17105646, ECO:0000269|PubMed:2172980, ECO:0000269|PubMed:24717288, ECO:0000269|PubMed:7911242, ECO:0000269|PubMed:7923219, ECO:0000269|PubMed:9065413, ECO:0000303|PubMed:10455171}.; SUBCELLULAR LOCATION: [Antiplasmin-cleaving enzyme FAP, soluble form]: Secreted {ECO:0000269|PubMed:14751930, ECO:0000269|PubMed:16223769, ECO:0000269|PubMed:24371721}. Note=Found in blood plasma and serum. {ECO:0000269|PubMed:14751930, ECO:0000269|PubMed:16223769, ECO:0000269|PubMed:24371721}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000303|PubMed:10644713}.","topological_domain":"TOPO_DOM 1..4; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255, ECO:0000303|PubMed:14751930\"; TOPO_DOM 26..760; /note=\"Extracellular\"; /evidence=\"ECO:0000255, ECO:0000303|PubMed:14751930\"","transmembrane":"TRANSMEM 5..25; /note=\"Helical; Signal-anchor for type II membrane protein\"; /evidence=\"ECO:0000255\""},"signal_peptides":[],"state":"available","topological_domains":[{"description":"Cytoplasmic","end":4,"evidence":"ECO:0000255, ECO:0000303|PubMed:14751930","source_location":"TOPO_DOM 1..4; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255, ECO:0000303|PubMed:14751930\"","start":1},{"description":"Extracellular","end":760,"evidence":"ECO:0000255, ECO:0000303|PubMed:14751930","source_location":"TOPO_DOM 26..760; /note=\"Extracellular\"; /evidence=\"ECO:0000255, ECO:0000303|PubMed:14751930\"","start":26}],"transmembrane_segments":[{"description":"Helical; Signal-anchor for type II membrane protein","end":25,"evidence":"ECO:0000255","source_location":"TRANSMEM 5..25; /note=\"Helical; Signal-anchor for type II membrane protein\"; /evidence=\"ECO:0000255\"","start":5}]},"uniprot_accession":"Q12884"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000091972","evidence_rank":151,"extracellular_segments":{"records":[{"basis":"reviewed-uniprot-topological-domain","end":232,"evidence_class":"source-annotated-topology","length":202,"sequence":"QVQVVTQDEREQLYTPASLKCSLQNAQEALIVTWQKKKAVSPENMVTFSENHGVVIQPAYKDKINITQLGLQNSTITFWNITLEDEGCYMCLFNTFGFGKISGTACLTVYVQPIVSLHYKFSEDHLNITCSATARPAPMVFWKVPRSGIENSTVTLSHPNGTTSVTSILHIKDPKNQVGKEVICQVLHLGTVTDFKQTVNKG","sequence_sha256":"d0b8277597db4f2521f3e66daafc6c15ece2c66a1ed3cb0fc6ca67873e02b753","start":31}],"state":"source-annotated"},"gene_symbol":"CD200","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MERLVIRMPFSHLSTYSLVWVMAAVVLCTAQVQVVTQDEREQLYTPASLKCSLQNAQEALIVTWQKKKAVSPENMVTFSENHGVVIQPAYKDKINITQLGLQNSTITFWNITLEDEGCYMCLFNTFGFGKISGTACLTVYVQPIVSLHYKFSEDHLNITCSATARPAPMVFWKVPRSGIENSTVTLSHPNGTTSVTSILHIKDPKNQVGKEVICQVLHLGTVTDFKQTVNKGYWFSVPLLLSIVSLVILLVLISILLYWKRHRNQDRGELSQGVQKMT","length":278,"sha256":"0bb64c2c264604736cb55682994d6fc7658581911a587b755f518dc673c57a98","state":"available"},"source_refs":[{"artifact":{"bytes":6088,"format":"json","sha256":"3be3c01d01a2a62733ae522bb3a638b2f9b09c1773c8eea1c39aa7b01fb67b3e","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/P41217"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"P41217","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"retained-unmodeled","target_id":"T-ENSG00000091972","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":278},"entry_name":"OX2G_HUMAN","gene_names":"CD200 MOX1 MOX2 My033","lipidation_sites":[],"protein_names":"OX-2 membrane glycoprotein (CD antigen CD200)","raw_fields":{"lipidation":"","signal_peptide":"SIGNAL 1..30; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.","topological_domain":"TOPO_DOM 31..232; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 260..278; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 233..259; /note=\"Helical\"; /evidence=\"ECO:0000255\""},"signal_peptides":[{"description":null,"end":30,"evidence":"ECO:0000255","source_location":"SIGNAL 1..30; /evidence=\"ECO:0000255\"","start":1}],"state":"available","topological_domains":[{"description":"Extracellular","end":232,"evidence":"ECO:0000255","source_location":"TOPO_DOM 31..232; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":31},{"description":"Cytoplasmic","end":278,"evidence":"ECO:0000255","source_location":"TOPO_DOM 260..278; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":260}],"transmembrane_segments":[{"description":"Helical","end":259,"evidence":"ECO:0000255","source_location":"TRANSMEM 233..259; 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Associated with the plasma membrane when palmitoylated.","topological_domain":"","transmembrane":""},"signal_peptides":[],"state":"available","topological_domains":[],"transmembrane_segments":[]},"uniprot_accession":"P03372"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000168036","evidence_rank":156,"extracellular_segments":{"records":[],"state":"not-explicitly-annotated"},"gene_symbol":"CTNNB1","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL","length":781,"sha256":"1e713d035af00ae7ec7e42f80259ed46e06120d2d5c617d320c91de02ce4dd1d","state":"available"},"source_refs":[{"artifact":{"bytes":3261,"format":"json","sha256":"7174ae19131ceb530b2ac1b80575de0d1718daa51fb8ebea66f0a0455cba2eda","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/P35222"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"P35222","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"retained-unmodeled","target_id":"T-ENSG00000168036","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":781},"entry_name":"CTNB1_HUMAN","gene_names":"CTNNB1 CTNNB OK/SW-cl.35 PRO2286","lipidation_sites":[],"protein_names":"Catenin beta-1 (Beta-catenin)","raw_fields":{"lipidation":"","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22294297, ECO:0000269|PubMed:25183871, ECO:0000269|PubMed:29739711, ECO:0000269|PubMed:29910125, ECO:0000269|PubMed:31801859}. Nucleus {ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:24342833, ECO:0000269|PubMed:25183871, ECO:0000269|PubMed:28829046, ECO:0000269|PubMed:29367600, ECO:0000269|PubMed:29739711, ECO:0000269|PubMed:29910125, ECO:0000269|PubMed:30714168, ECO:0000269|PubMed:31801859}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:B6V8E6}. Cell junction, adherens junction {ECO:0000269|PubMed:10725230, ECO:0000269|PubMed:22294297}. Cell junction {ECO:0000250|UniProtKB:B6V8E6}. Cell membrane {ECO:0000269|PubMed:11790773, ECO:0000269|PubMed:24342833}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Synapse {ECO:0000250|UniProtKB:Q02248}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q02248}. Note=Colocalized with RAPGEF2 and TJP1 at cell-cell contacts (By similarity). Cytoplasmic when it is un-stable (highly phosphorylated) or bound to CDH1. Translocates to the nucleus when it is stabilized (low level of phosphorylation). Interaction with GLIS2 and MUC1 promotes nuclear translocation. Interaction with EMD inhibits nuclear localization. The majority of CTNNB1 is localized to the cell membrane. In interphase, colocalizes with CROCC between CEP250 puncta at the proximal end of centrioles, and this localization is dependent on CROCC and CEP250. In mitosis, when NEK2 activity increases, it localizes to centrosomes at spindle poles independent of CROCC. Colocalizes with CDK5 in the cell-cell contacts and plasma membrane of undifferentiated and differentiated neuroblastoma cells. Interaction with FAM53B promotes translocation to the nucleus (PubMed:25183871). Translocates to the nucleus in the presence of SNAIL1 (By similarity). Ca(2+)-mediated localization to the cell membrane in dental epithelial cells is inhibited via WNT3A (By similarity). Localizes to cell-cell contacts as keratinocyte differentiation progresses (By similarity). {ECO:0000250|UniProtKB:B6V8E6, ECO:0000250|UniProtKB:Q02248, ECO:0000269|PubMed:25183871}.","topological_domain":"","transmembrane":""},"signal_peptides":[],"state":"available","topological_domains":[],"transmembrane_segments":[]},"uniprot_accession":"P35222"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000157765","evidence_rank":157,"extracellular_segments":{"records":[{"basis":"reviewed-uniprot-topological-domain","end":135,"evidence_class":"source-annotated-topology","length":14,"sequence":"FQLVGGKMAGQFFS","sequence_sha256":"ad2b2d50fc80017ad71946812d9f32419570087c74ddcb173b5253f6befa78b0","start":122},{"basis":"reviewed-uniprot-topological-domain","end":362,"evidence_class":"source-annotated-topology","length":129,"sequence":"VEVATHYLEIITQLIVESFHFKNGEDAPDLLKVITKPFTKLIVQLDKKVISQIAMNDEKAKNKSLVKIWCKTFTNKTQINVTVPSTANCTSPSLCWTDGIQNWTMKNVTYKENIAKCQHIFVNFHLPDL","sequence_sha256":"964c4be47604821cc47f72af73331a636eb688d839c7638b76b1e93fc956b9ea","start":234},{"basis":"reviewed-uniprot-topological-domain","end":485,"evidence_class":"source-annotated-topology","length":57,"sequence":"IVQSSSVFTSALTPLIGIGVITIERAYPLTLGSNIGTTTTAILAALASPGNALRSSL","sequence_sha256":"0183894c145574f200dbc96b2c6fb3fed24619d7eafea9431d7ed7f7def64057","start":429},{"basis":"reviewed-uniprot-topological-domain","end":552,"evidence_class":"source-annotated-topology","length":6,"sequence":"LSLAGW","sequence_sha256":"bc776b938b925066f4d91cc281af61e0e7941842d7c16305f7762718c499ccbd","start":547}],"state":"source-annotated"},"gene_symbol":"SLC34A2","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MAPWPELGDAQPNPDKYLEGAAGQQPTAPDKSKETNKTDNTEAPVTKIELLPSYSTATLIDEPTEVDDPWNLPTLQDSGIKWSERDTKGKILCFFQGIGRLILLLGFLYFFVCSLDILSSAFQLVGGKMAGQFFSNSSIMSNPLLGLVIGVLVTVLVQSSSTSTSIVVSMVSSSLLTVRAAIPIIMGANIGTSITNTIVALMQVGDRSEFRRAFAGATVHDFFNWLSVLVLLPVEVATHYLEIITQLIVESFHFKNGEDAPDLLKVITKPFTKLIVQLDKKVISQIAMNDEKAKNKSLVKIWCKTFTNKTQINVTVPSTANCTSPSLCWTDGIQNWTMKNVTYKENIAKCQHIFVNFHLPDLAVGTILLILSLLVLCGCLIMIVKILGSVLKGQVATVIKKTINTDFPFPFAWLTGYLAILVGAGMTFIVQSSSVFTSALTPLIGIGVITIERAYPLTLGSNIGTTTTAILAALASPGNALRSSLQIALCHFFFNISGILLWYPIPFTRLPIRMAKGLGNISAKYRWFAVFYLIIFFFLIPLTVFGLSLAGWRVLVGVGVPVVFIIILVLCLRLLQSRCPRVLPKKLQNWNFLPLWMRSLKPWDAVVSKFTGCFQMRCCCCCRVCCRACCLLCDCPKCCRCSKCCEDLEEAQEGQDVPVKAPETFDNITISREAQGEVPASDSKTECTAL","length":690,"sha256":"33ce6c59e28a7373fce51debe32cec8d891ef691c2e77a0655a74040da25eef9","state":"available"},"source_refs":[{"artifact":{"bytes":5988,"format":"json","sha256":"3d9aac403b6eff3ce404fc1967369e495d0bd1457027ca601085bbb9da517ed2","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/O95436"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"O95436","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"retained-unmodeled","target_id":"T-ENSG00000157765","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":690},"entry_name":"NPT2B_HUMAN","gene_names":"SLC34A2","lipidation_sites":[],"protein_names":"Sodium-dependent phosphate transport protein 2B (Sodium-phosphate transport protein 2B) (Na(+)-dependent phosphate cotransporter 2B) (NaPi3b) (Sodium/phosphate cotransporter 2B) (Na(+)/Pi cotransporter 2B) (NaPi-2b) (Solute carrier family 34 member 2)","raw_fields":{"lipidation":"","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q9DBP0}; Multi-pass membrane protein {ECO:0000255}. Note=Localized at the brush border membranes of enterocytes. {ECO:0000250|UniProtKB:Q9DBP0}.","topological_domain":"TOPO_DOM 1..100; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 122..135; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 157..212; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 234..362; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 384..407; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 429..485; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 507..525; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 547..552; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 574..689; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 101..121; /note=\"Helical; Name=M1\"; /evidence=\"ECO:0000255\"; TRANSMEM 136..156; /note=\"Helical; Name=M2\"; /evidence=\"ECO:0000255\"; TRANSMEM 213..233; /note=\"Helical; Name=M3\"; /evidence=\"ECO:0000255\"; TRANSMEM 363..383; /note=\"Helical; Name=M4\"; /evidence=\"ECO:0000255\"; TRANSMEM 408..428; /note=\"Helical; Name=M5\"; /evidence=\"ECO:0000255\"; TRANSMEM 486..506; /note=\"Helical; Name=M6\"; /evidence=\"ECO:0000255\"; TRANSMEM 526..546; /note=\"Helical; Name=M7\"; /evidence=\"ECO:0000255\"; TRANSMEM 553..573; /note=\"Helical; Name=M8\"; /evidence=\"ECO:0000255\""},"signal_peptides":[],"state":"available","topological_domains":[{"description":"Cytoplasmic","end":100,"evidence":"ECO:0000255","source_location":"TOPO_DOM 1..100; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":1},{"description":"Extracellular","end":135,"evidence":"ECO:0000255","source_location":"TOPO_DOM 122..135; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":122},{"description":"Cytoplasmic","end":212,"evidence":"ECO:0000255","source_location":"TOPO_DOM 157..212; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":157},{"description":"Extracellular","end":362,"evidence":"ECO:0000255","source_location":"TOPO_DOM 234..362; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":234},{"description":"Cytoplasmic","end":407,"evidence":"ECO:0000255","source_location":"TOPO_DOM 384..407; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":384},{"description":"Extracellular","end":485,"evidence":"ECO:0000255","source_location":"TOPO_DOM 429..485; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":429},{"description":"Cytoplasmic","end":525,"evidence":"ECO:0000255","source_location":"TOPO_DOM 507..525; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":507},{"description":"Extracellular","end":552,"evidence":"ECO:0000255","source_location":"TOPO_DOM 547..552; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":547},{"description":"Cytoplasmic","end":689,"evidence":"ECO:0000255","source_location":"TOPO_DOM 574..689; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":574}],"transmembrane_segments":[{"description":"Helical; Name=M1","end":121,"evidence":"ECO:0000255","source_location":"TRANSMEM 101..121; 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Single-pass type II membrane protein. Basolateral cell membrane {ECO:0000269|PubMed:11598187}; Single-pass type II membrane protein. Note=Targeted to the basolateral membrane in polarized epithelial cells and in hepatocytes, and to matrix vesicles in osteoblasts (PubMed:11598187). In bile duct cells and cancer cells, located to the apical cytoplasmic side (PubMed:11598187). {ECO:0000269|PubMed:11598187}.; SUBCELLULAR LOCATION: [Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form]: Secreted {ECO:0000250|UniProtKB:P06802}. Note=Secreted following proteolytic cleavage. {ECO:0000250|UniProtKB:P06802}.","topological_domain":"TOPO_DOM 1..76; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 98..925; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 77..97; /note=\"Helical; Signal-anchor for type II membrane protein\"; /evidence=\"ECO:0000255\""},"signal_peptides":[],"state":"available","topological_domains":[{"description":"Cytoplasmic","end":76,"evidence":"ECO:0000255","source_location":"TOPO_DOM 1..76; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":1},{"description":"Extracellular","end":925,"evidence":"ECO:0000255","source_location":"TOPO_DOM 98..925; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":98}],"transmembrane_segments":[{"description":"Helical; Signal-anchor for type II membrane protein","end":97,"evidence":"ECO:0000255","source_location":"TRANSMEM 77..97; /note=\"Helical; Signal-anchor for type II membrane protein\"; /evidence=\"ECO:0000255\"","start":77}]},"uniprot_accession":"P22413"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000110195","evidence_rank":163,"extracellular_segments":{"records":[{"basis":"interval-after-reviewed-signal-before-reviewed-gpi-anchor","end":233,"evidence_class":"topology-derived-construct-hypothesis","length":209,"sequence":"RIAWARTELLNVCMNAKHHKEKPGPEDKLHEQCRPWRKNACCSTNTSQEAHKDVSYLYRFNWNHCGEMAPACKRHFIQDTCLYECSPNLGPWIQQVDQSWRKERVLNVPLCKEDCEQWWEDCRTSYTCKSNWHKGWNWTSGFNKCAVGAACQPFHFYFPTPTVLCNEIWTHSYKVSNYSRGSGRCIQMWFDPAQGNPNEEVARFYAAAM","sequence_sha256":"1763e0ca38ce45887dd74a5254ea2af226763fe5e4d022b64cbdb8be0a9e4bb2","start":25}],"state":"topology-derived-gpi-span"},"gene_symbol":"FOLR1","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MAQRMTTQLLLLLVWVAVVGEAQTRIAWARTELLNVCMNAKHHKEKPGPEDKLHEQCRPWRKNACCSTNTSQEAHKDVSYLYRFNWNHCGEMAPACKRHFIQDTCLYECSPNLGPWIQQVDQSWRKERVLNVPLCKEDCEQWWEDCRTSYTCKSNWHKGWNWTSGFNKCAVGAACQPFHFYFPTPTVLCNEIWTHSYKVSNYSRGSGRCIQMWFDPAQGNPNEEVARFYAAAMSGAGPWAAWPFLLSLALMLLWLLS","length":257,"sha256":"32c0a619bf0594c065d065d7e221ae2f11c85a62b9d2c5337b44f3930ba58400","state":"available"},"source_refs":[{"artifact":{"bytes":2219,"format":"json","sha256":"16539879c5c6d39a02d1855faed565250472b2442881712c25bc6c6799df8d7f","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/P15328"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"P15328","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"retained-unmodeled","target_id":"T-ENSG00000110195","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":257},"entry_name":"FOLR1_HUMAN","gene_names":"FOLR1 FOLR","lipidation_sites":[{"description":"GPI-anchor amidated serine","end":234,"evidence":"ECO:0000269|PubMed:17566972, ECO:0000269|PubMed:7578066","source_location":"LIPID 234; /note=\"GPI-anchor amidated serine\"; /evidence=\"ECO:0000269|PubMed:17566972, ECO:0000269|PubMed:7578066\"","start":234}],"protein_names":"Folate receptor alpha (FR-alpha) (Adult folate-binding protein) (FBP) (Folate receptor 1) (Folate receptor, adult) (KB cells FBP) (Ovarian tumor-associated antigen MOv18)","raw_fields":{"lipidation":"LIPID 234; /note=\"GPI-anchor amidated serine\"; /evidence=\"ECO:0000269|PubMed:17566972, ECO:0000269|PubMed:7578066\"","signal_peptide":"SIGNAL 1..24; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:2527252, ECO:0000269|PubMed:8033114, ECO:0000269|PubMed:8567728}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:17566972, ECO:0000269|PubMed:7578066}. Apical cell membrane {ECO:0000269|PubMed:10787414}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:17566972, ECO:0000269|PubMed:7578066}. Basolateral cell membrane {ECO:0000269|PubMed:10787414}; Lipid-anchor, GPI-like-anchor {ECO:0000269|PubMed:17566972, ECO:0000269|PubMed:7578066}. Secreted {ECO:0000305|PubMed:3476960}. Cytoplasmic vesicle {ECO:0000269|PubMed:8567728}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:8567728}. Endosome {ECO:0000269|PubMed:8567728}. Note=Endocytosed into cytoplasmic vesicles and then recycled to the cell membrane. {ECO:0000269|PubMed:8567728}.","topological_domain":"","transmembrane":""},"signal_peptides":[{"description":null,"end":24,"evidence":"ECO:0000255","source_location":"SIGNAL 1..24; /evidence=\"ECO:0000255\"","start":1}],"state":"available","topological_domains":[],"transmembrane_segments":[]},"uniprot_accession":"P15328"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000198910","evidence_rank":164,"extracellular_segments":{"records":[{"basis":"reviewed-uniprot-topological-domain","end":1120,"evidence_class":"source-annotated-topology","length":1101,"sequence":"IQIPEEYEGHHVMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFSTPEGVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQATTKEGPGEAIVREGGTMALSGISDFGNISATAGENYSVVSWVPKEGQCNFRFHILFKALGEEKGGASLSPQYVSYNQSSYTQWDLQPDTDYEIHLFKERMFRHQMAVKTNGTGRVRLPPAGFATE","sequence_sha256":"ee0bd09fb94f65bdc4ad7b079165201daf8c065b0ec89de0e723f26d72d15acf","start":20}],"state":"source-annotated"},"gene_symbol":"L1CAM","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MVVALRYVWPLLLCSPCLLIQIPEEYEGHHVMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFSTPEGVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQATTKEGPGEAIVREGGTMALSGISDFGNISATAGENYSVVSWVPKEGQCNFRFHILFKALGEEKGGASLSPQYVSYNQSSYTQWDLQPDTDYEIHLFKERMFRHQMAVKTNGTGRVRLPPAGFATEGWFIGFVSAIILLLLVLLILCFIKRSKGGKYSVKDKEDTQVDSEARPMKDETFGEYRSLESDNEEKAFGSSQPSLNGDIKPLGSDDSLADYGGSVDVQFNEDGSFIGQYSGKKEKEAAGGNDSSGATSPINPAVALE","length":1257,"sha256":"5decc8013d23181976e7f7ac6ce215562fad67f012b82010dea68fbc53f7164e","state":"available"},"source_refs":[{"artifact":{"bytes":12197,"format":"json","sha256":"7eb26b357daaf0d47e05810d9be898dfe147a56c05de15f9919b0aa82b4c0e50","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/P32004"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"P32004","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"retained-unmodeled","target_id":"T-ENSG00000198910","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":1257},"entry_name":"L1CAM_HUMAN","gene_names":"L1CAM CAML1 MIC5","lipidation_sites":[],"protein_names":"Neural cell adhesion molecule L1 (N-CAM-L1) (NCAM-L1) (CD antigen CD171)","raw_fields":{"lipidation":"","signal_peptide":"SIGNAL 1..19; /evidence=\"ECO:0000269|PubMed:3136168\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12514225, ECO:0000269|PubMed:20621658, ECO:0000269|PubMed:22973895, ECO:0000269|PubMed:26891472}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q05695}. 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Cell membrane {ECO:0000250|UniProtKB:Q4LDG0}; Multi-pass membrane protein {ECO:0000255}.","topological_domain":"TOPO_DOM 1..30; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000305|PubMed:11980911\"; TOPO_DOM 77..690; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000305|PubMed:11980911\"","transmembrane":"TRANSMEM 31..51; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 56..76; /note=\"Helical\"; /evidence=\"ECO:0000255\""},"signal_peptides":[],"state":"available","topological_domains":[{"description":"Cytoplasmic","end":30,"evidence":"ECO:0000305|PubMed:11980911","source_location":"TOPO_DOM 1..30; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000305|PubMed:11980911\"","start":1},{"description":"Cytoplasmic","end":690,"evidence":"ECO:0000305|PubMed:11980911","source_location":"TOPO_DOM 77..690; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000305|PubMed:11980911\"","start":77}],"transmembrane_segments":[{"description":"Helical","end":51,"evidence":"ECO:0000255","source_location":"TRANSMEM 31..51; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":31},{"description":"Helical","end":76,"evidence":"ECO:0000255","source_location":"TRANSMEM 56..76; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":56}]},"uniprot_accession":"Q9Y2P5"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000050405","evidence_rank":173,"extracellular_segments":{"records":[],"state":"not-explicitly-annotated"},"gene_symbol":"LIMA1","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MESSPFNRRQWTSLSLRVTAKELSLVNKNKSSAIVEIFSKYQKAAEETNMEKKRSNTENLSQHFRKGTLTVLKKKWENPGLGAESHTDSLRNSSTEIRHRADHPPAEVTSHAASGAKADQEEQIHPRSRLRSPPEALVQGRYPHIKDGEDLKDHSTESKKMENCLGESRHEVEKSEISENTDASGKIEKYNVPLNRLKMMFEKGEPTQTKILRAQSRSASGRKISENSYSLDDLEIGPGQLSSSTFDSEKNESRRNLELPRLSETSIKDRMAKYQAAVSKQSSSTNYTNELKASGGEIKIHKMEQKENVPPGPEVCITHQEGEKISANENSLAVRSTPAEDDSRDSQVKSEVQQPVHPKPLSPDSRASSLSESSPPKAMKKFQAPARETCVECQKTVYPMERLLANQQVFHISCFRCSYCNNKLSLGTYASLHGRIYCKPHFNQLFKSKGNYDEGFGHRPHKDLWASKNENEEILERPAQLANARETPHSPGVEDAPIAKVGVLAASMEAKASSQQEKEDKPAETKKLRIAWPPPTELGSSGSALEEGIKMSKPKWPPEDEISKPEVPEDVDLDLKKLRRSSSLKERSRPFTVAASFQSTSVKSPKTVSPPIRKGWSMSEQSEESVGGRVAERKQVENAKASKKNGNVGKTTWQNKESKGETGKRSKEGHSLEMENENLVENGADSDEDDNSFLKQQSPQEPKSLNWSSFVDNTFAEEFTTQNQKSQDVELWEGEVVKELSVEEQIKRNRYYDEDEDEE","length":759,"sha256":"d09ccefe7c2bfdced1a34d5b22166e6c404cde3a727eb657af6f0552c68bdaf5","state":"available"},"source_refs":[{"artifact":{"bytes":14006,"format":"json","sha256":"63e3dd9b82cf4617e2e09bee8be5689c83413376c9175925a61f4f15bf3bbfad","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/Q9UHB6"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"Q9UHB6","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"retained-unmodeled","target_id":"T-ENSG00000050405","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":759},"entry_name":"LIMA1_HUMAN","gene_names":"LIMA1 EPLIN SREBP3 PP624","lipidation_sites":[],"protein_names":"LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm)","raw_fields":{"lipidation":"","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cytoplasm. Cell junction, focal adhesion {ECO:0000269|PubMed:10618726, ECO:0000269|PubMed:24694988}. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:10618726}. Cell membrane {ECO:0000250|UniProtKB:Q9ERG0}. Cell projection, ruffle {ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. Cell projection, lamellipodium {ECO:0000269|PubMed:33999101}. Note=Expressed in the brush border membrane of the small intestine and colocalizes with NPC1L1 and MYO5B (PubMed:29880681). Colocalizes with PXN at focal adhesions in mesangial cells (PubMed:24694988). Colocalizes with actin stress fibers in quiescent cells. PDGF stimulation induced disassembly of stress fibers and formation of peripheral and dorsal ruffles, where LIMA1 is relocalized (By similarity). Localized at the lamellipodia, just behind lamellipodia actin ruffles (PubMed:33999101). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:24694988, ECO:0000269|PubMed:29880681, ECO:0000269|PubMed:33999101}.","topological_domain":"","transmembrane":""},"signal_peptides":[],"state":"available","topological_domains":[],"transmembrane_segments":[]},"uniprot_accession":"Q9UHB6"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000147162","evidence_rank":174,"extracellular_segments":{"records":[],"state":"not-explicitly-annotated"},"gene_symbol":"OGT","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MASSVGNVADSTEPTKRMLSFQGLAELAHREYQAGDFEAAERHCMQLWRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYPLSHGFRKAIAERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYVSSDFGNHPTSHLMQSIPGMHNPDKFEVFCYALSPDDGTNFRVKVMAEANHFIDLSQIPCNGKAADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSGALFMDYIITDQETSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHLKKKAVIDFKSNGHIYDNRIVLNGIDLKAFLDSLPDVKIVKMKCPDGGDNADSSNTALNMPVIPMNTIAEAVIEMINRGQIQITINGFSISNGLATTQINNKAATGEEVPRTIIVTTRSQYGLPEDAIVYCNFNQLYKIDPSTLQMWANILKRVPNSVLWLLRFPAVGEPNIQQYAQNMGLPQNRIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMPGETLASRVAASQLTCLGCLELIAKNRQEYEDIAVKLGTDLEYLKKVRGKVWKQRISSPLFNTKQYTMELERLYLQMWEHYAAGNKPDHMIKPVEVTESA","length":1046,"sha256":"b606c098eae182300f53c1c144db0b2dcc69e268edb382758e324acb4ebe6ea2","state":"available"},"source_refs":[{"artifact":{"bytes":13669,"format":"json","sha256":"4780877c88fc27cc0270a0b3c96cda92d538e56724741bb23535f56edeaa3c3b","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/O15294"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"O15294","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"retained-unmodeled","target_id":"T-ENSG00000147162","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":1046},"entry_name":"OGT1_HUMAN","gene_names":"OGT","lipidation_sites":[],"protein_names":"UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (EC 2.4.1.255) (O-GlcNAc transferase subunit p110) (O-linked N-acetylglucosamine transferase 110 kDa subunit) (OGT)","raw_fields":{"lipidation":"","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26678539, ECO:0000269|PubMed:27713473}. Cytoplasm {ECO:0000269|PubMed:26678539, ECO:0000269|PubMed:27713473}. Note=Predominantly localizes to the nucleus (PubMed:26678539). Translocates into the nucleus via association with importin KPNA1 (PubMed:27713473). {ECO:0000269|PubMed:26678539, ECO:0000269|PubMed:27713473}.; SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion {ECO:0000269|PubMed:20824293}. Membrane {ECO:0000269|PubMed:20824293}. Note=Associates with the mitochondrial inner membrane. {ECO:0000269|PubMed:20824293}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:21285374}. Nucleus {ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:21285374}. Cell membrane {ECO:0000250|UniProtKB:P56558}. Mitochondrion membrane {ECO:0000250|UniProtKB:P56558}. Cell projection {ECO:0000250|UniProtKB:P56558}. Note=Mostly in the nucleus. Retained in the nucleus via interaction with HCFC1 (PubMed:21285374). After insulin induction, translocated from the nucleus to the cell membrane via phosphatidylinositide binding. Colocalizes with AKT1 at the plasma membrane. TRAK1 recruits this protein to mitochondria. In the absence of TRAK1, localizes in cytosol and nucleus (By similarity). {ECO:0000250|UniProtKB:P56558, ECO:0000269|PubMed:21285374}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000303|PubMed:31527085}. Nucleus {ECO:0000303|PubMed:31527085}.","topological_domain":"","transmembrane":""},"signal_peptides":[],"state":"available","topological_domains":[],"transmembrane_segments":[]},"uniprot_accession":"O15294"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000198561","evidence_rank":175,"extracellular_segments":{"records":[],"state":"not-explicitly-annotated"},"gene_symbol":"CTNND1","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MDDSEVESTASILASVKEQEAQFEKLTRALEEERRHVSAQLERVRVSPQDANPLMANGTLTRRHQNGRFVGDADLERQKFSDLKLNGPQDHSHLLYSTIPRMQEPGQIVETYTEEDPEGAMSVVSVETSDDGTTRRTETTVKKVVKTVTTRTVQPVAMGPDGLPVDASSVSNNYIQTLGRDFRKNGNGGPGPYVGQAGTATLPRNFHYPPDGYSRHYEDGYPGGSDNYGSLSRVTRIEERYRPSMEGYRAPSRQDVYGPQPQVRVGGSSVDLHRFHPEPYGLEDDQRSMGYDDLDYGMMSDYGTARRTGTPSDPRRRLRSYEDMIGEEVPSDQYYWAPLAQHERGSLASLDSLRKGGPPPPNWRQPELPEVIAMLGFRLDAVKSNAAAYLQHLCYRNDKVKTDVRKLKGIPVLVGLLDHPKKEVHLGACGALKNISFGRDQDNKIAIKNCDGVPALVRLLRKARDMDLTEVITGTLWNLSSHDSIKMEIVDHALHALTDEVIIPHSGWEREPNEDCKPRHIEWESVLTNTAGCLRNVSSERSEARRKLRECDGLVDALIFIVQAEIGQKDSDSKLVENCVCLLRNLSYQVHREIPQAERYQEAAPNVANNTGPHAASCFGAKKGKDEWFSRGKKPIEDPANDTVDFPKRTSPARGYELLFQPEVVRIYISLLKESKTPAILEASAGAIQNLCAGRWTYGRYIRSALRQEKALSAIADLLTNEHERVVKAASGALRNLAVDARNKELIGKHAIPNLVKNLPGGQQNSSWNFSEDTVISILNTINEVIAENLEAAKKLRETQGIEKLVLINKSGNRSEKEVRAAALVLQTIWGYKELRKPLEKEGWKKSDFQVNLNNASRSQSSHSYDDSTLPLIDRNQKSDKKPDREEIQMSNMGSNTKSLDNNYSTPNERGDHNRTLDRSGDLGDMEPLKGTTPLMQDEGQESLEEELDVLVLDDEGGQVSYPSMQKI","length":968,"sha256":"3654c491186ae9d8a1ff3ccfdd2d1fcaa05e4f792654a32899f5896089dc67e8","state":"available"},"source_refs":[{"artifact":{"bytes":99757,"format":"json","sha256":"5c7d66f6119d255f69ef393963aff55bb7cf29a42df1238eb22ab961cd22cf47","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/O60716"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"O60716","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"retained-unmodeled","target_id":"T-ENSG00000198561","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":968},"entry_name":"CTND1_HUMAN","gene_names":"CTNND1 KIAA0384","lipidation_sites":[],"protein_names":"Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas))","raw_fields":{"lipidation":"","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000269|PubMed:11896187}. Cytoplasm {ECO:0000269|PubMed:15240885, ECO:0000269|PubMed:17047063}. Nucleus {ECO:0000269|PubMed:11896187, ECO:0000269|PubMed:17115030}. Cell membrane {ECO:0000269|PubMed:15240885, ECO:0000269|PubMed:17047063}. Cell junction {ECO:0000269|PubMed:18343367}. Note=Interaction with GLIS2 promotes nuclear translocation (By similarity). Detected at cell-cell contacts (PubMed:15240885, PubMed:17047063). NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm (PubMed:17047063). CDH1 enhances cell membrane localization (PubMed:15240885). Localizes to cell-cell contacts as keratinocyte differentiation progresses (By similarity). {ECO:0000250|UniProtKB:P30999, ECO:0000269|PubMed:11896187, ECO:0000269|PubMed:15240885, ECO:0000269|PubMed:17047063}.; SUBCELLULAR LOCATION: [Isoform 1A]: Nucleus {ECO:0000269|PubMed:11896187}.; SUBCELLULAR LOCATION: [Isoform 2A]: Nucleus {ECO:0000269|PubMed:11896187}.; SUBCELLULAR LOCATION: [Isoform 3A]: Nucleus {ECO:0000269|PubMed:11896187}.; SUBCELLULAR LOCATION: [Isoform 4A]: Cytoplasm {ECO:0000269|PubMed:11896187}.; SUBCELLULAR LOCATION: [Isoform 1AB]: Cytoplasm {ECO:0000269|PubMed:11896187}.","topological_domain":"","transmembrane":""},"signal_peptides":[],"state":"available","topological_domains":[],"transmembrane_segments":[]},"uniprot_accession":"O60716"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000197122","evidence_rank":176,"extracellular_segments":{"records":[],"state":"not-explicitly-annotated"},"gene_symbol":"SRC","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL","length":536,"sha256":"bfb0c691493b552212f52a3e68ec9d6c2e67dc37339f19b6e71c22fd202292f8","state":"available"},"source_refs":[{"artifact":{"bytes":7954,"format":"json","sha256":"6d79df371835baac31e17ffa6527203caada14150dc980954eb36d0d02aac355","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/P12931"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"P12931","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"retained-unmodeled","target_id":"T-ENSG00000197122","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":536},"entry_name":"SRC_HUMAN","gene_names":"SRC SRC1","lipidation_sites":[{"description":"N-myristoyl glycine","end":2,"evidence":"ECO:0000269|PubMed:7525268","source_location":"LIPID 2; /note=\"N-myristoyl glycine\"; /evidence=\"ECO:0000269|PubMed:7525268\"","start":2}],"protein_names":"Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)","raw_fields":{"lipidation":"LIPID 2; /note=\"N-myristoyl glycine\"; /evidence=\"ECO:0000269|PubMed:7525268\"","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:7525268}; Lipid-anchor {ECO:0000269|PubMed:22801373}. Mitochondrion inner membrane {ECO:0000269|PubMed:12615910}. Nucleus {ECO:0000269|PubMed:7853507}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:7525268}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19307596}. Cell junction, focal adhesion {ECO:0000269|PubMed:22801373}. Cell junction {ECO:0000269|PubMed:22294297}. Note=Localizes to focal adhesion sites following integrin engagement (PubMed:22801373). Localization to focal adhesion sites requires myristoylation and the SH3 domain (PubMed:7525268). 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The source snapshot is bounded to the registered query families.","query_id":"Q-LIT-001","record_count":2570,"record_unit":"unique PubMed records","retrieved_at":"2026-09-04","source_class":"literature-and-preprints","status":"partial"},{"artifact":{"bytes":157776,"format":"json","sha256":"dba49f42ee8450c01d13d3b406c9136dbc5a0fe321c55f16198834b6366f3ff3","storage":"atlas-workspace"},"limitation":"All 40 registered concepts completed at a hard 100-record-per-concept cutoff; 0 reached the cutoff. 6 unique 10.1101 records were hydrated; 7 other DOI records remain discovery metadata rather than bioRxiv/medRxiv hydrations.","query_id":"Q-PREPRINT-001","record_count":13,"record_unit":"unique preprint DOI records","retrieved_at":"2026-09-04","source_class":"literature-and-preprints","status":"complete"},{"query_id":"Q-CANCER-001","record_count":601,"record_unit":"normalized disease-linked entities","retrieved_at":"2026-09-04","source_class":"cancer-genomics-and-expression","status":"complete"},{"artifact":{"bytes":361923,"format":"json","sha256":"32175b4de01ff8b2dcb5fcc6981a8bbc86bf83956e489090340e65b763579544","storage":"atlas-workspace"},"collection_schema":"codex-surface-cbioportal-phenotype-overlay/v0.1","limitation":"Mapped 184 of 185 retained targets and retained 107,566 transcript-expression measurements. Unresolved: T-ENSG00000130202 (PVRL2). This is a public-cohort MSS proxy, not patient-specific protein or surface abundance.","query_id":"Q-CBIO-001","record_count":184,"record_unit":"retained targets mapped to the declared cBioPortal cohort","retrieved_at":"2026-09-04","source_class":"cancer-genomics-and-expression","status":"partial","unresolved_target_ids":["T-ENSG00000130202"]},{"query_id":"Q-PROTEOME-001","record_count":3567,"record_unit":"global Cancer Surfaceome Atlas GESP records","retrieved_at":"2026-09-04","source_class":"surface-and-proteome-studies","status":"complete"},{"limitation":"The snapshot includes the published COAD single-cell expression matrix; it does not include a patient-specific single-cell or spatial dataset.","query_id":"Q-CELL-001","record_count":899,"record_unit":"Cancer Surfaceome Atlas single-cell gene rows","retrieved_at":"2026-09-04","source_class":"single-cell-and-spatial-context","status":"partial"},{"artifact":{"bytes":654039,"format":"json","sha256":"eea1865692a579a31ede2a43eae56ab31a001cfbb148d1d0904acf9bf676ac00","storage":"atlas-workspace"},"collection_schema":"codex-surface-hpa-normal-tissue-overlay/v0.1","limitation":"Human Protein Atlas normal-tissue summaries represent 184 of 185 retained targets. Unresolved: T-NECTIN4 (NECTIN4). The overlay is expression context, not accessible surface density or a therapeutic-index model.","query_id":"Q-NORMAL-001","record_count":184,"record_unit":"retained targets represented in the HPA normal-tissue overlay","retrieved_at":"2026-09-04","source_class":"normal-tissue-and-cell-context","status":"partial","unresolved_target_ids":["T-NECTIN4"]},{"artifact":{"bytes":1308203,"format":"json","sha256":"5072da13c060ee603b135dd781b7593cea6ae848c92a2408d1dd0ad8a12cd29b","storage":"atlas-workspace"},"limitation":"Canonical sequence and reviewed topology are present for 185 of 185 retained targets, with 0 unresolved canonical records. Target-specific isoform and proteoform reconciliation remains outside this collection.","query_id":"Q-SEQ-001","record_count":185,"record_unit":"retained targets with canonical protein sequence and reviewed topology","retrieved_at":"2026-09-05","source_class":"sequence-topology-and-proteoforms","status":"partial"},{"limitation":"ClinicalTrials.gov yielded 766 normalized intervention candidates and 140 target assignments. Bounded measured activity evidence for Structure-A targets is recorded separately under Q-ACTIVITY-001; neither lane is an exhaustive intervention review.","query_id":"Q-THERAPY-001","record_count":495,"record_unit":"unique ClinicalTrials.gov studies","retrieved_at":"2026-09-04","source_class":"interventions-and-trials","status":"partial"},{"artifact":{"bytes":240108,"format":"json","sha256":"26aaa2e132443759fd200931f372de154e56b370d6ecd291299684383a3ce627","storage":"atlas-workspace"},"collection_schema":"codex-surface-known-compound-interaction-collection/v0.1","limitation":"The bounded Structure-A pass ran 73 registered queries for 10 targets and retained 57 measured records: 31 from ChEMBL and 26 from BindingDB. 8 PDB-indexed BindingDB queries failed. All records remain target-level or PDB-indexed target matches without extracellular-site localization; none establishes action, selectivity, safety, or efficacy.","query_id":"Q-ACTIVITY-001","record_count":57,"record_unit":"measured ChEMBL or BindingDB protein-target activity records","retrieved_at":"2026-09-05","source_class":"interventions-and-trials","status":"partial"},{"artifact":{"bytes":228650,"format":"json","sha256":"42015660cf5e51fb59cf5159077b29a3daae6012fca9fde8307e9487815ab72d","storage":"atlas-workspace"},"collection_schema":"codex-surface-structure-collection/v0.1","limitation":"The library contains 15 distinct experimental PDB entries and 16 total records, including 1 target-only compatibility record. Accession-level deposited complex searches are not complete for every retained target.","query_id":"Q-STRUCTURE-001","record_count":15,"record_unit":"distinct verified experimental RCSB PDB entries","retrieved_at":"2026-09-04","source_class":"structures-and-complexes","status":"partial"}]},"source_collections":{"discovered-entities.json":{"atlas_id":"pmmr-mucinous-colon","records":[{"aliases":[],"association":{"associated_target_rank":1,"datasource_scores":[{"id":"cancer_gene_census","score":0.4559480982087158},{"id":"europepmc","score":0.38756022390692535}],"score":0.2889653808156401,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000133703","exclusion_id":"X-ENSG00000133703","identifiers":{"approved_symbol":"KRAS","ensembl_gene_id":"ENSG00000133703"},"preferred_label":"KRAS","reconciliation":{"canonical_uniprot_accessions":["P01116"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-cytoplasmic-face-or-peripheral-membrane","reasons":["Reviewed UniProt places the canonical protein on the cytoplasmic face or as a peripheral membrane protein without an extracellular domain."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P01116","entry_name":"RASK_HUMAN","gene_names":"KRAS KRAS2 RASK2","lipidation":"LIPID 180; /note=\"S-palmitoyl cysteine\"; /evidence=\"ECO:0000305|PubMed:29239724\"; LIPID 182; /note=\"N6-palmitoyl lysine\"; /evidence=\"ECO:0000269|PubMed:29239724\"; LIPID 184; /note=\"N6-palmitoyl lysine\"; /evidence=\"ECO:0000305|PubMed:29239724\"; LIPID 185; /note=\"N6-palmitoyl lysine\"; /evidence=\"ECO:0000305|PubMed:29239724\"; LIPID 186; /note=\"S-farnesyl cysteine\"; /evidence=\"ECO:0000269|PubMed:27791178, ECO:0000305|PubMed:24415755, ECO:0007744|PDB:5TAR, ECO:0007744|PDB:5TB5\"","provisional_surface_signal":"plasma-membrane-annotation","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22431598, ECO:0000269|PubMed:23524970, ECO:0000269|PubMed:23698361, ECO:0000269|PubMed:29239724}; Lipid-anchor {ECO:0000269|PubMed:29239724, ECO:0000305|PubMed:23698361}; Cytoplasmic side {ECO:0000305|PubMed:23698361}. Endomembrane system {ECO:0000269|PubMed:29239724}. Cytoplasm {ECO:0000269|PubMed:23524970, ECO:0000269|PubMed:23698361}.; SUBCELLULAR LOCATION: [Isoform 2B]: Cell membrane {ECO:0000269|PubMed:28619714}; Lipid-anchor {ECO:0000305|PubMed:28619714}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"plasma-membrane-annotation","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":2,"datasource_scores":[{"id":"cancer_gene_census","score":0.3039653988058105},{"id":"europepmc","score":0.12213256217787655}],"score":0.18850233463930827,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000087460","identifiers":{"approved_symbol":"GNAS","ensembl_gene_id":"ENSG00000087460"},"preferred_label":"GNAS","reconciliation":{"canonical_uniprot_accessions":["O95467","P63092","P84996","Q5JWF2"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"conflicting-surface-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt localization places the canonical protein on the cytoplasmic face or as a peripheral membrane protein."],"state":"unresolved","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"unresolved","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"O95467","entry_name":"GNAS3_HUMAN","gene_names":"GNAS GNAS1","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"SIGNAL 1..46; /evidence=\"ECO:0000250\"","subcellular_location":"SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle {ECO:0000250}. Secreted {ECO:0000250}. Note=Neuroendocrine secretory granules. {ECO:0000250}.","topological_domain":"","transmembrane":""},{"accession":"P63092","entry_name":"GNAS2_HUMAN","gene_names":"GNAS GNAS1 GSP","lipidation":"LIPID 2; /note=\"N-palmitoyl glycine\"; /evidence=\"ECO:0000250|UniProtKB:P04896\"; LIPID 3; /note=\"S-palmitoyl cysteine\"; /evidence=\"ECO:0000269|PubMed:21044946, ECO:0000305|PubMed:12135370\"","provisional_surface_signal":"plasma-membrane-annotation","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12135370}; Peripheral membrane protein {ECO:0000269|PubMed:12135370}; Cytoplasmic side {ECO:0000269|PubMed:12135370}. Note=Associated to the plasma membrane via lipid-anchor. {ECO:0000269|PubMed:12135370}.","topological_domain":"","transmembrane":""},{"accession":"P84996","entry_name":"ALEX_HUMAN","gene_names":"GNAS GNAS1","lipidation":"","provisional_surface_signal":"plasma-membrane-annotation","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Cell projection, ruffle {ECO:0000250}. Note=Predominantly associated with cell membrane ruffles. {ECO:0000250}.","topological_domain":"","transmembrane":""},{"accession":"Q5JWF2","entry_name":"GNAS1_HUMAN","gene_names":"GNAS GNAS1","lipidation":"","provisional_surface_signal":"plasma-membrane-annotation","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27120771}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q63803}. Apical cell membrane {ECO:0000269|PubMed:27120771}. Note=Associated to the plasma membrane via lipid-anchor. {ECO:0000269|PubMed:27120771}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"plasma-membrane-annotation","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":3,"datasource_scores":[{"id":"europepmc","score":0.6662145265041709}],"score":0.08100246569562582,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000101076","exclusion_id":"X-ENSG00000101076","identifiers":{"approved_symbol":"HNF4A","ensembl_gene_id":"ENSG00000101076"},"preferred_label":"HNF4A","reconciliation":{"canonical_uniprot_accessions":["P41235"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P41235","entry_name":"HNF4A_HUMAN","gene_names":"HNF4A HNF4 NR2A1 TCF14","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":4,"datasource_scores":[{"id":"europepmc","score":0.40889514134456195}],"score":0.04971598988342321,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000157764","identifiers":{"approved_symbol":"BRAF","ensembl_gene_id":"ENSG00000157764"},"preferred_label":"BRAF","reconciliation":{"canonical_uniprot_accessions":["P15056"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"extracellular-accessibility-unresolved","reasons":["A membrane or cell-surface localization is reported, but extracellular orientation or anchoring is unresolved."],"state":"unresolved","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"unresolved","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P15056","entry_name":"BRAF_HUMAN","gene_names":"BRAF BRAF1 RAFB1","lipidation":"","provisional_surface_signal":"plasma-membrane-annotation","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:19710016}. Cell membrane {ECO:0000269|PubMed:19710016}. Note=Colocalizes with RGS14 and RAF1 in both the cytoplasm and membranes. {ECO:0000250}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"plasma-membrane-annotation","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":5,"datasource_scores":[{"id":"europepmc","score":0.40114059035731126}],"score":0.04877314381006336,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000215182","exclusion_id":"X-ENSG00000215182","identifiers":{"approved_symbol":"MUC5AC","ensembl_gene_id":"ENSG00000215182"},"preferred_label":"MUC5AC","reconciliation":{"canonical_uniprot_accessions":["P98088"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P98088","entry_name":"MUC5A_HUMAN","gene_names":"MUC5AC MUC5","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"SIGNAL 1..27; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:14718370, ECO:0000269|PubMed:31732694}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":6,"datasource_scores":[{"id":"europepmc","score":0.3947902840663297}],"score":0.048001034456352454,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000141510","exclusion_id":"X-ENSG00000141510","identifiers":{"approved_symbol":"TP53","ensembl_gene_id":"ENSG00000141510"},"preferred_label":"TP53","reconciliation":{"canonical_uniprot_accessions":["P04637"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P04637","entry_name":"P53_HUMAN","gene_names":"TP53 P53","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15340061, ECO:0000269|PubMed:17170702, ECO:0000269|PubMed:19011621, ECO:0000269|PubMed:19033443, ECO:0000269|PubMed:21597459, ECO:0000269|PubMed:22726440, ECO:0000269|PubMed:22914926, ECO:0000269|PubMed:24625977, ECO:0000269|PubMed:26634371}. Nucleus {ECO:0000269|PubMed:15340061, ECO:0000269|PubMed:17170702, ECO:0000269|PubMed:17591690, ECO:0000269|PubMed:18206965, ECO:0000269|PubMed:19011621, ECO:0000269|PubMed:21597459, ECO:0000269|PubMed:22914926, ECO:0000269|PubMed:24625977, ECO:0000269|PubMed:26634371}. Nucleus, PML body {ECO:0000269|PubMed:11025664, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:36108750}. Endoplasmic reticulum {ECO:0000269|PubMed:17170702}. Mitochondrion matrix {ECO:0000269|PubMed:22726440, ECO:0000269|PubMed:25168243, ECO:0000269|PubMed:27323408}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:28842590}. Note=Recruited into PML bodies together with CHEK2 (PubMed:12810724). Translocates to mitochondria upon oxidative stress (PubMed:22726440). Translocates to mitochondria in response to mitomycin C treatment (PubMed:27323408). Competitive inhibition of TP53 interaction with HSPA9/MOT-2 by UBXN2A results in increased protein abundance and subsequent translocation of TP53 to the nucleus (PubMed:24625977). {ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:22726440, ECO:0000269|PubMed:24625977, ECO:0000269|PubMed:27323408}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:23752197}. Cytoplasm. Note=Predominantly nuclear but localizes to the cytoplasm when expressed with isoform 4.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus. Cytoplasm. Note=Localized mainly in the nucleus with minor staining in the cytoplasm.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus. Cytoplasm. Note=Localized in the nucleus in most cells but found in the cytoplasm in some cells.; SUBCELLULAR LOCATION: [Isoform 4]: Nucleus. Cytoplasm. Note=Predominantly nuclear but translocates to the cytoplasm following cell stress.; SUBCELLULAR LOCATION: [Isoform 7]: Nucleus. Cytoplasm. Note=Localized mainly in the nucleus with minor staining in the cytoplasm.; SUBCELLULAR LOCATION: [Isoform 8]: Nucleus. Cytoplasm. Note=Localized in both nucleus and cytoplasm in most cells. In some cells, forms foci in the nucleus that are different from nucleoli.; SUBCELLULAR LOCATION: [Isoform 9]: Cytoplasm.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":7,"datasource_scores":[{"id":"europepmc","score":0.39346632178752144}],"score":0.047840058967519736,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000012048","exclusion_id":"X-ENSG00000012048","identifiers":{"approved_symbol":"BRCA1","ensembl_gene_id":"ENSG00000012048"},"preferred_label":"BRCA1","reconciliation":{"canonical_uniprot_accessions":["P38398"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P38398","entry_name":"BRCA1_HUMAN","gene_names":"BRCA1 RNF53","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15133502, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:26778126, ECO:0000269|PubMed:9528852}. Chromosome {ECO:0000269|PubMed:23269703, ECO:0000269|PubMed:25472942, ECO:0000269|PubMed:26778126}. Cytoplasm {ECO:0000269|PubMed:20160719}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs); recruitment to DNA damage sites is mediated by ABRAXAS1 and the BRCA1-A complex (PubMed:26778126). Translocated to the cytoplasm during UV-induced apoptosis (PubMed:20160719). {ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:26778126}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000269|PubMed:8972225}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":8,"datasource_scores":[{"id":"europepmc","score":0.36022408727740296}],"score":0.04379826333949396,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000146648","identifiers":{"approved_symbol":"EGFR","ensembl_gene_id":"ENSG00000146648"},"preferred_label":"EGFR","query_expansion_seeds":[{"category":"signaling-receptors","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["P00533"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000146648","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P00533","entry_name":"EGFR_HUMAN","gene_names":"EGFR ERBB ERBB1 HER1","lipidation":"LIPID 1049; /note=\"S-palmitoyl cysteine\"; /evidence=\"ECO:0000269|PubMed:27153536\"; LIPID 1146; /note=\"S-palmitoyl cysteine\"; /evidence=\"ECO:0000269|PubMed:27153536\"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..24; /evidence=\"ECO:0000269|PubMed:15340161, ECO:0000269|PubMed:6328312, ECO:0000269|Ref.16\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17182860, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:23589287, ECO:0000269|PubMed:26918609, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:35538033}; Single-pass type I membrane protein {ECO:0000269|PubMed:27153536}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:27153536}; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Endosome {ECO:0000269|PubMed:17182860, ECO:0000269|PubMed:27153536}. Endosome membrane. Nucleus {ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:20551055, ECO:0000269|PubMed:20674546}. Note=In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER (PubMed:17909029, PubMed:20674546). Endocytosed upon activation by ligand (PubMed:17182860, PubMed:17909029, PubMed:27153536, PubMed:2790960). Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF) (PubMed:20551055). {ECO:0000269|PubMed:17182860, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:20674546, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.","topological_domain":"TOPO_DOM 25..645; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 669..1210; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 646..668; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":9,"datasource_scores":[{"id":"europepmc","score":0.2822038892107815}],"score":0.03431208709140239,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000136352","exclusion_id":"X-ENSG00000136352","identifiers":{"approved_symbol":"NKX2-1","ensembl_gene_id":"ENSG00000136352"},"preferred_label":"NKX2-1","reconciliation":{"canonical_uniprot_accessions":["P43699"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P43699","entry_name":"NKX21_HUMAN","gene_names":"NKX2-1 NKX2A TITF1 TTF1","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P50220}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":10,"datasource_scores":[{"id":"europepmc","score":0.258370588984939}],"score":0.03141428764819966,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000197181","exclusion_id":"X-ENSG00000197181","identifiers":{"approved_symbol":"PIWIL2","ensembl_gene_id":"ENSG00000197181"},"preferred_label":"PIWIL2","reconciliation":{"canonical_uniprot_accessions":["Q8TC59"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q8TC59","entry_name":"PIWL2_HUMAN","gene_names":"PIWIL2 HILI","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8CDG1}. Note=Present in chromatoid body. Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250|UniProtKB:Q8CDG1}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":11,"datasource_scores":[{"id":"europepmc","score":0.2535178546674215}],"score":0.030824262319350516,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000105388","identifiers":{"approved_symbol":"CEACAM5","ensembl_gene_id":"ENSG00000105388"},"preferred_label":"CEACAM5","query_expansion_seeds":[{"category":"lineage-and-tumor-antigens","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["P06731"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt records an integral or GPI-anchored membrane form."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000105388","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P06731","entry_name":"CEAM5_HUMAN","gene_names":"CEACAM5 CEA","lipidation":"LIPID 676; /note=\"GPI-anchor amidated alanine\"; /evidence=\"ECO:0000269|PubMed:3387431\"","provisional_surface_signal":"plasma-membrane-annotation","signal_peptide":"SIGNAL 1..34","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10864933, ECO:0000269|PubMed:18086185, ECO:0000269|PubMed:2317824, ECO:0000269|PubMed:2803308, ECO:0000269|PubMed:3387431}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:10864933, ECO:0000269|PubMed:18086185, ECO:0000269|PubMed:2317824, ECO:0000269|PubMed:2803308, ECO:0000269|PubMed:3387431}; Extracellular side {ECO:0000269|PubMed:10864933, ECO:0000269|PubMed:18086185, ECO:0000269|PubMed:2317824, ECO:0000269|PubMed:2803308, ECO:0000269|PubMed:3387431}. Apical cell membrane {ECO:0000269|PubMed:10436421}. Cell surface {ECO:0000269|PubMed:2317824, ECO:0000269|PubMed:2803308}. Note=Localized to the apical glycocalyx surface. {ECO:0000269|PubMed:10436421}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"plasma-membrane-annotation","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":12,"datasource_scores":[{"id":"europepmc","score":0.2176230031896039}],"score":0.026459945181538453,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000125482","exclusion_id":"X-ENSG00000125482","identifiers":{"approved_symbol":"TTF1","ensembl_gene_id":"ENSG00000125482"},"preferred_label":"TTF1","reconciliation":{"canonical_uniprot_accessions":["Q15361"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P43699","entry_name":"NKX21_HUMAN","gene_names":"NKX2-1 NKX2A TITF1 TTF1","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P50220}.","topological_domain":"","transmembrane":""},{"accession":"Q15361","entry_name":"TTF1_HUMAN","gene_names":"TTF1","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q62187}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q62187}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q62187}. Note=May be localized to the nucleolus in an NPM1/B23-dependent manner. May be displaced from the nucleolus into the nucleoplasm in an CDKN2A/ARF-dependent manner. May shuttle back and forth from nucleoplasm to nucleolus. {ECO:0000250|UniProtKB:Q62187}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":13,"datasource_scores":[{"id":"europepmc","score":0.20986446612217172}],"score":0.02551661445599777,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000127616","exclusion_id":"X-ENSG00000127616","identifiers":{"approved_symbol":"SMARCA4","ensembl_gene_id":"ENSG00000127616"},"preferred_label":"SMARCA4","reconciliation":{"canonical_uniprot_accessions":["P51532"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P51532","entry_name":"SMCA4_HUMAN","gene_names":"SMARCA4 BAF190A BRG1 SNF2B SNF2L4","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00549, ECO:0000269|PubMed:20418909, ECO:0000269|PubMed:25593309}. Note=Colocalizes with long non-coding RNA Evf2 in nuclear RNA clouds (By similarity). Localizes to sites of DNA damage (PubMed:25593309). {ECO:0000250|UniProtKB:Q3TKT4, ECO:0000269|PubMed:25593309}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":14,"datasource_scores":[{"id":"europepmc","score":0.20288629264466287}],"score":0.024668165142386934,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000171094","identifiers":{"approved_symbol":"ALK","ensembl_gene_id":"ENSG00000171094"},"preferred_label":"ALK","reconciliation":{"canonical_uniprot_accessions":["Q9UM73"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000171094","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q9UM73","entry_name":"ALK_HUMAN","gene_names":"ALK","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..18; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:34819673, ECO:0000269|PubMed:9174053}; Single-pass type I membrane protein {ECO:0000269|PubMed:16317043, ECO:0000269|PubMed:9174053}. Note=Membrane attachment is essential for promotion of neuron-like differentiation and cell proliferation arrest through specific activation of the MAP kinase pathway. {ECO:0000269|PubMed:16317043}.","topological_domain":"TOPO_DOM 19..1038; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 1060..1620; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 1039..1059; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":15,"datasource_scores":[{"id":"europepmc","score":0.19051378607660419}],"score":0.02316383958511195,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000185499","identifiers":{"approved_symbol":"MUC1","ensembl_gene_id":"ENSG00000185499"},"preferred_label":"MUC1","query_expansion_seeds":[{"category":"lineage-and-tumor-antigens","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["P15941"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000185499","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P15941","entry_name":"MUC1_HUMAN","gene_names":"MUC1 PUM","lipidation":"LIPID 1184; /note=\"S-palmitoyl cysteine\"; /evidence=\"ECO:0000269|PubMed:16507569\"; LIPID 1186; /note=\"S-palmitoyl cysteine\"; /evidence=\"ECO:0000269|PubMed:16507569\"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..23; /evidence=\"ECO:0000269|PubMed:10373415, ECO:0000269|PubMed:11341784\"","subcellular_location":"SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:11118479, ECO:0000269|PubMed:12832415, ECO:0000269|PubMed:12939402, ECO:0000269|PubMed:15471854, ECO:0000269|PubMed:15972891, ECO:0000269|PubMed:16507569, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:17545600}; Single-pass type I membrane protein {ECO:0000269|PubMed:11118479, ECO:0000269|PubMed:12832415, ECO:0000269|PubMed:12939402, ECO:0000269|PubMed:15471854, ECO:0000269|PubMed:15972891, ECO:0000269|PubMed:16507569, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:17545600}. Note=Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis, internalized and recycled to the cell membrane. Located to microvilli and to the tips of long filopodial protusions.; SUBCELLULAR LOCATION: [Isoform 5]: Secreted.; SUBCELLULAR LOCATION: [Isoform Y]: Secreted.; SUBCELLULAR LOCATION: [Isoform 9]: Secreted.; SUBCELLULAR LOCATION: [Mucin-1 subunit beta]: Cell membrane. Cytoplasm. Nucleus. Note=On EGF and PDGFRB stimulation, transported to the nucleus through interaction with CTNNB1, a process which is stimulated by phosphorylation. On HRG stimulation, colocalizes with JUP/gamma-catenin at the nucleus.","topological_domain":"TOPO_DOM 24..1158; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 1182..1255; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 1159..1181; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":16,"datasource_scores":[{"id":"europepmc","score":0.18085941228945726}],"score":0.021990001353739755,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000173585","identifiers":{"approved_symbol":"CCR9","ensembl_gene_id":"ENSG00000173585"},"preferred_label":"CCR9","reconciliation":{"canonical_uniprot_accessions":["P51686"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000173585","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P51686","entry_name":"CCR9_HUMAN","gene_names":"CCR9 GPR28","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:27926729}; Multi-pass membrane protein {ECO:0000305|PubMed:27926729}.","topological_domain":"TOPO_DOM 1..48; /note=\"Extracellular\"; /evidence=\"ECO:0000269|PubMed:27926729\"; TOPO_DOM 75..85; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:27926729\"; TOPO_DOM 110..120; /note=\"Extracellular\"; /evidence=\"ECO:0000269|PubMed:27926729\"; TOPO_DOM 151..159; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:27926729\"; TOPO_DOM 186..208; /note=\"Extracellular\"; /evidence=\"ECO:0000269|PubMed:27926729\"; TOPO_DOM 244..248; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:27926729\"; TOPO_DOM 284..290; /note=\"Extracellular\"; /evidence=\"ECO:0000269|PubMed:27926729\"; TOPO_DOM 322..369; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255, ECO:0000269|PubMed:27926729\"","transmembrane":"TRANSMEM 49..74; /note=\"Helical; Name=1\"; /evidence=\"ECO:0000269|PubMed:27926729\"; TRANSMEM 86..109; /note=\"Helical; Name=2\"; /evidence=\"ECO:0000269|PubMed:27926729\"; TRANSMEM 121..150; /note=\"Helical; Name=3\"; /evidence=\"ECO:0000269|PubMed:27926729\"; TRANSMEM 160..185; /note=\"Helical; Name=4\"; /evidence=\"ECO:0000269|PubMed:27926729\"; TRANSMEM 209..243; /note=\"Helical; Name=5\"; /evidence=\"ECO:0000269|PubMed:27926729\"; TRANSMEM 249..283; /note=\"Helical; Name=6\"; /evidence=\"ECO:0000269|PubMed:27926729\"; TRANSMEM 291..321; /note=\"Helical; Name=7\"; /evidence=\"ECO:0000269|PubMed:27926729\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":17,"datasource_scores":[{"id":"europepmc","score":0.173260277319312}],"score":0.021066051717028005,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000186951","exclusion_id":"X-ENSG00000186951","identifiers":{"approved_symbol":"PPARA","ensembl_gene_id":"ENSG00000186951"},"preferred_label":"PPARA","reconciliation":{"canonical_uniprot_accessions":["Q07869"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q07869","entry_name":"PPARA_HUMAN","gene_names":"PPARA NR1C1 PPAR","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":18,"datasource_scores":[{"id":"europepmc","score":0.16718096934319582}],"score":0.020326892007658602,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000083457","identifiers":{"approved_symbol":"ITGAE","ensembl_gene_id":"ENSG00000083457"},"preferred_label":"ITGAE","reconciliation":{"canonical_uniprot_accessions":["P38570"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000083457","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P38570","entry_name":"ITAE_HUMAN","gene_names":"ITGAE","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..18; 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/note=\"S-palmitoyl cysteine\"; /evidence=\"ECO:0000250\"","provisional_surface_signal":"plasma-membrane-annotation","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:12682286, ECO:0000269|PubMed:20074560}. Cytoplasm {ECO:0000269|PubMed:12682286, ECO:0000269|PubMed:24498420}. Cell membrane {ECO:0000269|PubMed:12682286}; Peripheral membrane protein {ECO:0000269|PubMed:12682286}; Cytoplasmic side {ECO:0000269|PubMed:12682286}. Note=A minor fraction is associated with the inner membrane.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Single-pass type I membrane protein. Note=Associated with the inner membrane via palmitoylation (Probable). At least a subset exists as a transmembrane protein with a N-terminal extracellular domain. {ECO:0000305}.; SUBCELLULAR LOCATION: Nucleus. Golgi apparatus. Cell membrane. Note=Colocalizes with ZDHHC7 and ZDHHC21 in the Golgi apparatus where most probably palmitoylation occurs. Associated with the plasma membrane when palmitoylated.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"plasma-membrane-annotation","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":20,"datasource_scores":[{"id":"europepmc","score":0.15760013188781222}],"score":0.019161994776450874,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000117983","exclusion_id":"X-ENSG00000117983","identifiers":{"approved_symbol":"MUC5B","ensembl_gene_id":"ENSG00000117983"},"preferred_label":"MUC5B","reconciliation":{"canonical_uniprot_accessions":["Q9HC84"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q9HC84","entry_name":"MUC5B_HUMAN","gene_names":"MUC5B MUC5","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"SIGNAL 1..25; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Secreted.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":21,"datasource_scores":[{"id":"europepmc","score":0.15198269940290526}],"score":0.01847899273423509,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000125999","exclusion_id":"X-ENSG00000125999","identifiers":{"approved_symbol":"BPIFB1","ensembl_gene_id":"ENSG00000125999"},"preferred_label":"BPIFB1","reconciliation":{"canonical_uniprot_accessions":["Q8TDL5"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q8TDL5","entry_name":"BPIB1_HUMAN","gene_names":"BPIFB1 C20orf114 LPLUNC1 UNQ706/PRO1357","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"SIGNAL 1..21; 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Colocalizes with PDLIM4 at the perinuclear region, but not at focal adhesions (PubMed:19307596). {ECO:0000269|PubMed:19307596, ECO:0000269|PubMed:22801373, ECO:0000269|PubMed:7525268}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"plasma-membrane-annotation","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":50,"datasource_scores":[{"id":"europepmc","score":0.09379005741380571}],"score":0.011403572882322929,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000119042","exclusion_id":"X-ENSG00000119042","identifiers":{"approved_symbol":"SATB2","ensembl_gene_id":"ENSG00000119042"},"preferred_label":"SATB2","reconciliation":{"canonical_uniprot_accessions":["Q9UPW6"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q9UPW6","entry_name":"SATB2_HUMAN","gene_names":"SATB2 KIAA1034","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus matrix {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00374, ECO:0000269|PubMed:14701874}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":51,"datasource_scores":[{"id":"europepmc","score":0.09254057696976899}],"score":0.011251653353734256,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000153563","identifiers":{"approved_symbol":"CD8A","ensembl_gene_id":"ENSG00000153563"},"preferred_label":"CD8A","reconciliation":{"canonical_uniprot_accessions":["P01732"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000153563","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P01732","entry_name":"CD8A_HUMAN","gene_names":"CD8A MAL","lipidation":"LIPID 206; /note=\"S-palmitoyl cysteine\"; /evidence=\"ECO:0000269|PubMed:17341584\"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..21","subcellular_location":"SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:1460019, ECO:0000269|PubMed:17341584, ECO:0000269|PubMed:17678538}; Single-pass type I membrane protein. 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Chromosome {ECO:0000269|PubMed:23622243}. Note=Associates with H3K36me3 via its PWWP domain.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":68,"datasource_scores":[{"id":"europepmc","score":0.08363935348514741}],"score":0.010169387775189196,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000171862","exclusion_id":"X-ENSG00000171862","identifiers":{"approved_symbol":"PTEN","ensembl_gene_id":"ENSG00000171862"},"preferred_label":"PTEN","reconciliation":{"canonical_uniprot_accessions":["P60484"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P60484","entry_name":"PTEN_HUMAN","gene_names":"PTEN MMAC1 TEP1","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15987703, ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:19473982, ECO:0000269|PubMed:25801959, ECO:0000269|PubMed:9187108}. Nucleus {ECO:0000269|PubMed:15987703, ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:19473982, ECO:0000269|PubMed:25801959}. Nucleus, PML body {ECO:0000269|PubMed:18716620}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:O54857}. Postsynaptic density {ECO:0000250|UniProtKB:O54857}. Note=Monoubiquitinated form is nuclear. Nonubiquitinated form is cytoplasmic. Colocalized with PML and USP7 in PML nuclear bodies (PubMed:18716620). XIAP/BIRC4 promotes its nuclear localization (PubMed:19473982). Associates with the postsynaptic density in response to NMDAR activation (By similarity). {ECO:0000250|UniProtKB:O54857, ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:19473982}.; SUBCELLULAR LOCATION: [Isoform alpha]: Secreted {ECO:0000269|PubMed:23744781, ECO:0000269|PubMed:24768297}. 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Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19632184, ECO:0000269|PubMed:20937854}. Cell projection, lamellipodium {ECO:0000269|PubMed:19151759}. Cell projection, ruffle membrane {ECO:0000269|PubMed:19151759}. Cytoplasm {ECO:0000269|PubMed:10947987}. Cell membrane {ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:16611247, ECO:0000269|PubMed:20937854}. Note=Associated with the microtubule network at the growing distal tip of microtubules (PubMed:19632184). MAPRE1 may be required for targeting to the growing microtubule plus ends (PubMed:19632184). Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment (PubMed:19151759). The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane (PubMed:20937854). {ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19632184, ECO:0000269|PubMed:20937854}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"plasma-membrane-annotation","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":72,"datasource_scores":[{"id":"europepmc","score":0.08190178801156561}],"score":0.0099581238623378,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000124664","exclusion_id":"X-ENSG00000124664","identifiers":{"approved_symbol":"SPDEF","ensembl_gene_id":"ENSG00000124664"},"preferred_label":"SPDEF","reconciliation":{"canonical_uniprot_accessions":["O95238"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"O95238","entry_name":"SPDEF_HUMAN","gene_names":"SPDEF PDEF PSE","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":73,"datasource_scores":[{"id":"europepmc","score":0.08149143472317777}],"score":0.009908230581955361,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000168036","identifiers":{"approved_symbol":"CTNNB1","ensembl_gene_id":"ENSG00000168036"},"preferred_label":"CTNNB1","reconciliation":{"canonical_uniprot_accessions":["P35222"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000168036","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P35222","entry_name":"CTNB1_HUMAN","gene_names":"CTNNB1 CTNNB OK/SW-cl.35 PRO2286","lipidation":"","provisional_surface_signal":"plasma-membrane-annotation","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22294297, ECO:0000269|PubMed:25183871, ECO:0000269|PubMed:29739711, ECO:0000269|PubMed:29910125, ECO:0000269|PubMed:31801859}. Nucleus {ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:24342833, ECO:0000269|PubMed:25183871, ECO:0000269|PubMed:28829046, ECO:0000269|PubMed:29367600, ECO:0000269|PubMed:29739711, ECO:0000269|PubMed:29910125, ECO:0000269|PubMed:30714168, ECO:0000269|PubMed:31801859}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:B6V8E6}. Cell junction, adherens junction {ECO:0000269|PubMed:10725230, ECO:0000269|PubMed:22294297}. Cell junction {ECO:0000250|UniProtKB:B6V8E6}. Cell membrane {ECO:0000269|PubMed:11790773, ECO:0000269|PubMed:24342833}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Synapse {ECO:0000250|UniProtKB:Q02248}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q02248}. Note=Colocalized with RAPGEF2 and TJP1 at cell-cell contacts (By similarity). Cytoplasmic when it is un-stable (highly phosphorylated) or bound to CDH1. Translocates to the nucleus when it is stabilized (low level of phosphorylation). Interaction with GLIS2 and MUC1 promotes nuclear translocation. Interaction with EMD inhibits nuclear localization. The majority of CTNNB1 is localized to the cell membrane. In interphase, colocalizes with CROCC between CEP250 puncta at the proximal end of centrioles, and this localization is dependent on CROCC and CEP250. In mitosis, when NEK2 activity increases, it localizes to centrosomes at spindle poles independent of CROCC. Colocalizes with CDK5 in the cell-cell contacts and plasma membrane of undifferentiated and differentiated neuroblastoma cells. Interaction with FAM53B promotes translocation to the nucleus (PubMed:25183871). Translocates to the nucleus in the presence of SNAIL1 (By similarity). Ca(2+)-mediated localization to the cell membrane in dental epithelial cells is inhibited via WNT3A (By similarity). Localizes to cell-cell contacts as keratinocyte differentiation progresses (By similarity). {ECO:0000250|UniProtKB:B6V8E6, ECO:0000250|UniProtKB:Q02248, ECO:0000269|PubMed:25183871}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"plasma-membrane-annotation","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":74,"datasource_scores":[{"id":"europepmc","score":0.07908955109388159}],"score":0.009616194775849699,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000148773","exclusion_id":"X-ENSG00000148773","identifiers":{"approved_symbol":"MKI67","ensembl_gene_id":"ENSG00000148773"},"preferred_label":"MKI67","reconciliation":{"canonical_uniprot_accessions":["P46013"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P46013","entry_name":"KI67_HUMAN","gene_names":"MKI67","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:15896774, ECO:0000269|PubMed:22002106, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474, ECO:0000269|PubMed:9510506}. Nucleus {ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:22002106}. Nucleus, nucleolus {ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:22002106, ECO:0000269|PubMed:2674163, ECO:0000269|PubMed:8799815}. Note=During early mitosis, relocalizes from nucleoli to the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the mitotic chromosome surface (PubMed:27362226). Associates with satellite DNA in G1 phase (PubMed:9510506). Binds tightly to chromatin in interphase, chromatin-binding decreases in mitosis when it associates with the surface of the condensed chromosomes (PubMed:15896774, PubMed:22002106). Predominantly localized in the G1 phase in the perinucleolar region, in the later phases it is also detected throughout the nuclear interior, being predominantly localized in the nuclear matrix (PubMed:22002106). {ECO:0000269|PubMed:15896774, ECO:0000269|PubMed:22002106, ECO:0000269|PubMed:27362226}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":75,"datasource_scores":[{"id":"europepmc","score":0.07903100368951074}],"score":0.009609076221802246,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000141448","exclusion_id":"X-ENSG00000141448","identifiers":{"approved_symbol":"GATA6","ensembl_gene_id":"ENSG00000141448"},"preferred_label":"GATA6","reconciliation":{"canonical_uniprot_accessions":["Q92908"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q92908","entry_name":"GATA6_HUMAN","gene_names":"GATA6","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19666519, ECO:0000269|PubMed:27756709}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":76,"datasource_scores":[{"id":"europepmc","score":0.0788621340235075}],"score":0.009588544007653096,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000108375","identifiers":{"approved_symbol":"RNF43","ensembl_gene_id":"ENSG00000108375"},"preferred_label":"RNF43","reconciliation":{"canonical_uniprot_accessions":["Q68DV7"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000108375","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q68DV7","entry_name":"RNF43_HUMAN","gene_names":"RNF43","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..23; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Nucleus envelope. Note=According to a report, may be secreted. {ECO:0000269|PubMed:15492824}.","topological_domain":"TOPO_DOM 24..197; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 219..783; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 198..218; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":77,"datasource_scores":[{"id":"europepmc","score":0.0788621340235075}],"score":0.009588544007653096,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000196611","identifiers":{"approved_symbol":"MMP1","ensembl_gene_id":"ENSG00000196611"},"preferred_label":"MMP1","reconciliation":{"canonical_uniprot_accessions":["P03956"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"extracellular-matrix-retention-accessibility-unresolved","reasons":["Canonical reviewed UniProt explicitly reports extracellular-matrix localization, which is within the broad extracellular target scope.","Disease-site retention, extracellular accessibility, and cell of origin require review before retaining this as an actionable matrix target; it is not an intracellular or soluble-only exclusion."],"state":"unresolved","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"unresolved","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P03956","entry_name":"MMP1_HUMAN","gene_names":"MMP1 CLG","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"SIGNAL 1..19","subcellular_location":"SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000305|PubMed:2167156}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":78,"datasource_scores":[{"id":"europepmc","score":0.07860882952450267}],"score":0.009557745686429371,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000167034","exclusion_id":"X-ENSG00000167034","identifiers":{"approved_symbol":"NKX3-1","ensembl_gene_id":"ENSG00000167034"},"preferred_label":"NKX3-1","reconciliation":{"canonical_uniprot_accessions":["Q99801"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q99801","entry_name":"NKX31_HUMAN","gene_names":"NKX3-1 NKX3.1 NKX3A","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:11137288}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":79,"datasource_scores":[{"id":"europepmc","score":0.07599134970145263}],"score":0.009239496367117545,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000066468","identifiers":{"approved_symbol":"FGFR2","ensembl_gene_id":"ENSG00000066468"},"preferred_label":"FGFR2","query_expansion_seeds":[{"category":"signaling-receptors","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["P21802"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000066468","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P21802","entry_name":"FGFR2_HUMAN","gene_names":"FGFR2 BEK KGFR KSAM","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..21; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Golgi apparatus. Cytoplasmic vesicle. Note=Detected on osteoblast plasma membrane lipid rafts. After ligand binding, the activated receptor is rapidly internalized and degraded.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Note=After ligand binding, the activated receptor is rapidly internalized and degraded.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane; Single-pass type I membrane protein. Note=After ligand binding, the activated receptor is rapidly internalized and degraded.; SUBCELLULAR LOCATION: [Isoform 8]: Secreted.; SUBCELLULAR LOCATION: [Isoform 13]: Secreted.","topological_domain":"TOPO_DOM 22..377; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 399..821; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 378..398; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":80,"datasource_scores":[{"id":"europepmc","score":0.07351234300452525}],"score":0.008938083463408023,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000047936","identifiers":{"approved_symbol":"ROS1","ensembl_gene_id":"ENSG00000047936"},"preferred_label":"ROS1","reconciliation":{"canonical_uniprot_accessions":["P08922"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000047936","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P08922","entry_name":"ROS1_HUMAN","gene_names":"ROS1 MCF3 ROS","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..27; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.","topological_domain":"TOPO_DOM 28..1859; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 1883..2347; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 1860..1882; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":81,"datasource_scores":[{"id":"europepmc","score":0.07295169571339452}],"score":0.008869916512432843,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000085563","identifiers":{"approved_symbol":"ABCB1","ensembl_gene_id":"ENSG00000085563"},"preferred_label":"ABCB1","reconciliation":{"canonical_uniprot_accessions":["P08183"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000085563","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P08183","entry_name":"MDR1_HUMAN","gene_names":"ABCB1 MDR1 PGY1","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:35970996}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}. Apical cell membrane {ECO:0000269|PubMed:28408210, ECO:0000269|PubMed:8898203}. Cytoplasm {ECO:0000269|PubMed:35970996}. Note=ABCB1 localization is influenced by C1orf115 expression levels (plasma membrane versus cytoplasm). Localized to the apical membrane of enterocytes (PubMed:28408210). {ECO:0000269|PubMed:28408210, ECO:0000269|PubMed:35970996}.","topological_domain":"TOPO_DOM 1..44; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000250\"; TOPO_DOM 68..116; /note=\"Extracellular\"; /evidence=\"ECO:0000250\"; TOPO_DOM 138..186; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000250\"; TOPO_DOM 209..215; /note=\"Extracellular\"; /evidence=\"ECO:0000250\"; TOPO_DOM 237..292; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000250\"; TOPO_DOM 317..330; /note=\"Extracellular\"; /evidence=\"ECO:0000250\"; TOPO_DOM 353..711; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000250\"; TOPO_DOM 733..756; /note=\"Extracellular\"; /evidence=\"ECO:0000250\"; TOPO_DOM 778..832; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000250\"; TOPO_DOM 854; /note=\"Extracellular\"; /evidence=\"ECO:0000250\"; TOPO_DOM 875..934; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000250\"; TOPO_DOM 958..973; /note=\"Extracellular\"; /evidence=\"ECO:0000250\"; TOPO_DOM 996..1280; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000250\"","transmembrane":"TRANSMEM 45..67; /note=\"Helical\"; /evidence=\"ECO:0000255|PROSITE-ProRule:PRU00441\"; TRANSMEM 117..137; /note=\"Helical\"; /evidence=\"ECO:0000255|PROSITE-ProRule:PRU00441\"; TRANSMEM 187..208; /note=\"Helical\"; /evidence=\"ECO:0000255|PROSITE-ProRule:PRU00441\"; TRANSMEM 216..236; /note=\"Helical\"; /evidence=\"ECO:0000255|PROSITE-ProRule:PRU00441\"; TRANSMEM 293..316; /note=\"Helical\"; /evidence=\"ECO:0000255|PROSITE-ProRule:PRU00441\"; TRANSMEM 331..352; /note=\"Helical\"; /evidence=\"ECO:0000255|PROSITE-ProRule:PRU00441\"; TRANSMEM 712..732; /note=\"Helical\"; /evidence=\"ECO:0000255|PROSITE-ProRule:PRU00441\"; TRANSMEM 757..777; /note=\"Helical\"; /evidence=\"ECO:0000255|PROSITE-ProRule:PRU00441\"; TRANSMEM 833..853; /note=\"Helical\"; /evidence=\"ECO:0000255|PROSITE-ProRule:PRU00441\"; TRANSMEM 855..874; /note=\"Helical\"; /evidence=\"ECO:0000255|PROSITE-ProRule:PRU00441\"; TRANSMEM 935..957; /note=\"Helical\"; /evidence=\"ECO:0000255|PROSITE-ProRule:PRU00441\"; TRANSMEM 974..995; /note=\"Helical\"; /evidence=\"ECO:0000255|PROSITE-ProRule:PRU00441\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":82,"datasource_scores":[{"id":"europepmc","score":0.07295169571339452}],"score":0.008869916512432843,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000103257","identifiers":{"approved_symbol":"SLC7A5","ensembl_gene_id":"ENSG00000103257"},"preferred_label":"SLC7A5","reconciliation":{"canonical_uniprot_accessions":["Q01650"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000103257","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q01650","entry_name":"LAT1_HUMAN","gene_names":"SLC7A5 CD98LC LAT1 MPE16","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:11742812}; Multi-pass membrane protein {ECO:0000269|PubMed:30867591}. Cell membrane {ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:9751058}; Multi-pass membrane protein {ECO:0000269|PubMed:30867591}. Lysosome membrane {ECO:0000269|PubMed:25998567}; Multi-pass membrane protein {ECO:0000305|PubMed:25998567}. Note=Located to the plasma membrane by SLC3A2/4F2hc (PubMed:9751058). Localized to the apical membrane of placental syncytiotrophoblastic cells (PubMed:11742812). Recruited to lysosomes by LAPTM4B (PubMed:25998567). {ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:9751058}.","topological_domain":"TOPO_DOM 1..49; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000305\"; TOPO_DOM 71..83; /note=\"Extracellular\"; /evidence=\"ECO:0000305\"; TOPO_DOM 105..126; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000305\"; TOPO_DOM 148..169; /note=\"Extracellular\"; /evidence=\"ECO:0000305\"; TOPO_DOM 191..192; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000305\"; TOPO_DOM 215..242; /note=\"Extracellular\"; /evidence=\"ECO:0000305\"; TOPO_DOM 264..276; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000305\"; TOPO_DOM 298..324; /note=\"Extracellular\"; /evidence=\"ECO:0000305\"; TOPO_DOM 346..369; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000305\"; TOPO_DOM 391..395; /note=\"Extracellular\"; /evidence=\"ECO:0000305\"; TOPO_DOM 417..430; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000305\"; TOPO_DOM 452..457; /note=\"Extracellular\"; /evidence=\"ECO:0000305\"; TOPO_DOM 479..507; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000305\"","transmembrane":"TRANSMEM 50..70; /note=\"Helical\"; /evidence=\"ECO:0000269|PubMed:30867591\"; TRANSMEM 84..104; /note=\"Helical\"; /evidence=\"ECO:0000269|PubMed:30867591\"; TRANSMEM 127..147; /note=\"Helical\"; /evidence=\"ECO:0000269|PubMed:30867591\"; TRANSMEM 170..190; /note=\"Helical\"; /evidence=\"ECO:0000269|PubMed:30867591\"; TRANSMEM 193..214; /note=\"Helical\"; /evidence=\"ECO:0000269|PubMed:30867591\"; TRANSMEM 243..263; /note=\"Helical\"; /evidence=\"ECO:0000269|PubMed:30867591\"; TRANSMEM 277..297; /note=\"Helical\"; /evidence=\"ECO:0000269|PubMed:30867591\"; TRANSMEM 325..345; /note=\"Helical\"; /evidence=\"ECO:0000269|PubMed:30867591\"; TRANSMEM 370..390; /note=\"Helical\"; /evidence=\"ECO:0000269|PubMed:30867591\"; TRANSMEM 396..416; /note=\"Helical\"; /evidence=\"ECO:0000269|PubMed:30867591\"; TRANSMEM 431..451; /note=\"Helical\"; /evidence=\"ECO:0000269|PubMed:30867591\"; TRANSMEM 458..478; /note=\"Helical\"; /evidence=\"ECO:0000269|PubMed:30867591\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":83,"datasource_scores":[{"id":"europepmc","score":0.07295169571339452}],"score":0.008869916512432843,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000169919","exclusion_id":"X-ENSG00000169919","identifiers":{"approved_symbol":"GUSB","ensembl_gene_id":"ENSG00000169919"},"preferred_label":"GUSB","reconciliation":{"canonical_uniprot_accessions":["P08236"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P08236","entry_name":"BGLR_HUMAN","gene_names":"GUSB","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"SIGNAL 1..22; /evidence=\"ECO:0000269|PubMed:1311180\"","subcellular_location":"SUBCELLULAR LOCATION: Lysosome.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":84,"datasource_scores":[{"id":"europepmc","score":0.07295169571339452}],"score":0.008869916512432843,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000113140","identifiers":{"approved_symbol":"SPARC","ensembl_gene_id":"ENSG00000113140"},"preferred_label":"SPARC","reconciliation":{"canonical_uniprot_accessions":["P09486"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"extracellular-matrix-retention-accessibility-unresolved","reasons":["Canonical reviewed UniProt explicitly reports extracellular-matrix localization, which is within the broad extracellular target scope.","Disease-site retention, extracellular accessibility, and cell of origin require review before retaining this as an actionable matrix target; it is not an intracellular or soluble-only exclusion."],"state":"unresolved","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"unresolved","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P09486","entry_name":"SPRC_HUMAN","gene_names":"SPARC ON","lipidation":"","provisional_surface_signal":"membrane-only","signal_peptide":"SIGNAL 1..17; /evidence=\"ECO:0000269|PubMed:2306517, ECO:0000269|PubMed:3597437\"","subcellular_location":"SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000269|PubMed:2306517, ECO:0000269|PubMed:3400777, ECO:0000269|PubMed:7495300, ECO:0000269|PubMed:9457905}. Note=In or around the basement membrane.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"membrane-only","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":85,"datasource_scores":[{"id":"europepmc","score":0.07295169571339452}],"score":0.008869916512432843,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000183578","identifiers":{"approved_symbol":"TIPE3","ensembl_gene_id":"ENSG00000183578"},"preferred_label":"TIPE3","reconciliation":{"canonical_uniprot_accessions":[],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-protein-identity-unresolved","reasons":["No canonical reviewed UniProt entry matched the discovery symbol."],"state":"unresolved","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"unresolved","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q5GJ75","entry_name":"TP8L3_HUMAN","gene_names":"TNFAIP8L3 TIPE3","lipidation":"","provisional_surface_signal":"plasma-membrane-annotation","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25479791}. Cell membrane {ECO:0000250|UniProtKB:Q3TBL6}. Note=On PDGF activation, translocates from cytoplasm to plasma membrane. {ECO:0000250|UniProtKB:Q3TBL6}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"plasma-membrane-annotation","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":86,"datasource_scores":[{"id":"europepmc","score":0.07295169571339452}],"score":0.008869916512432843,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000101842","identifiers":{"approved_symbol":"VSIG1","ensembl_gene_id":"ENSG00000101842"},"preferred_label":"VSIG1","reconciliation":{"canonical_uniprot_accessions":["Q86XK7"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000101842","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q86XK7","entry_name":"VSIG1_HUMAN","gene_names":"VSIG1 GPA34","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..21; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.","topological_domain":"TOPO_DOM 22..232; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 254..387; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 233..253; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":87,"datasource_scores":[{"id":"europepmc","score":0.07295169571339452}],"score":0.008869916512432843,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000138162","exclusion_id":"X-ENSG00000138162","identifiers":{"approved_symbol":"TACC2","ensembl_gene_id":"ENSG00000138162"},"preferred_label":"TACC2","reconciliation":{"canonical_uniprot_accessions":["O95359"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"O95359","entry_name":"TACC2_HUMAN","gene_names":"TACC2","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10749935}. Nucleus {ECO:0000269|PubMed:10749935, ECO:0000269|PubMed:14767476}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:15304323}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":88,"datasource_scores":[{"id":"europepmc","score":0.07295169571339452}],"score":0.008869916512432843,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000132646","exclusion_id":"X-ENSG00000132646","identifiers":{"approved_symbol":"PCNA","ensembl_gene_id":"ENSG00000132646"},"preferred_label":"PCNA","reconciliation":{"canonical_uniprot_accessions":["P12004"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P12004","entry_name":"PCNA_HUMAN","gene_names":"PCNA","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:24115439, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:38459011}. Note=Colocalizes with CREBBP, EP300 and POLD1 to sites of DNA damage (PubMed:24939902). Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase (PubMed:15543136). Co-localizes with SMARCA5/SNF2H and BAZ1B/WSTF at replication foci during S phase (PubMed:15543136). Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents. {ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:24939902}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":89,"datasource_scores":[{"id":"europepmc","score":0.07143186871936548}],"score":0.008685126585090493,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000007062","identifiers":{"approved_symbol":"PROM1","ensembl_gene_id":"ENSG00000007062"},"preferred_label":"PROM1","reconciliation":{"canonical_uniprot_accessions":["O43490"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000007062","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"O43490","entry_name":"PROM1_HUMAN","gene_names":"PROM1 PROML1 MSTP061","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..19; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, microvillus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250}. Endoplasmic reticulum. Endoplasmic reticulum-Golgi intermediate compartment. Note=Found in extracellular membrane particles in various body fluids such as cerebrospinal fluid, saliva, seminal fluid and urine.","topological_domain":"TOPO_DOM 20..108; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 130..157; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 179..433; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 455..486; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 508..792; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 814..865; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 109..129; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 158..178; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 434..454; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 487..507; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 793..813; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":90,"datasource_scores":[{"id":"europepmc","score":0.0710195238378582}],"score":0.008634991154549335,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000076242","exclusion_id":"X-ENSG00000076242","identifiers":{"approved_symbol":"MLH1","ensembl_gene_id":"ENSG00000076242"},"preferred_label":"MLH1","reconciliation":{"canonical_uniprot_accessions":["P40692"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P40692","entry_name":"MLH1_HUMAN","gene_names":"MLH1 COCA2","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11429708, ECO:0000269|PubMed:14676842, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:22753075, ECO:0000269|PubMed:30770470}. Chromosome {ECO:0000269|PubMed:26300262}. Note=Recruited to chromatin in a MCM9-dependent manner. {ECO:0000269|PubMed:26300262}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":91,"datasource_scores":[{"id":"europepmc","score":0.0709116467584841}],"score":0.008621874794767753,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000147889","exclusion_id":"X-ENSG00000147889","identifiers":{"approved_symbol":"CDKN2A","ensembl_gene_id":"ENSG00000147889"},"preferred_label":"CDKN2A","reconciliation":{"canonical_uniprot_accessions":["P42771","Q8N726"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P42771","entry_name":"CDN2A_HUMAN","gene_names":"CDKN2A CDKN2 MTS1","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17658461}. Nucleus {ECO:0000269|PubMed:17658461}.","topological_domain":"","transmembrane":""},{"accession":"Q8N726","entry_name":"ARF_HUMAN","gene_names":"CDKN2A CDKN2 MLM","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:16173922, ECO:0000269|PubMed:18305112, ECO:0000269|PubMed:22094112, ECO:0000269|PubMed:27323397}. Nucleus, nucleoplasm {ECO:0000269|PubMed:18305112, ECO:0000269|PubMed:27323397}.; SUBCELLULAR LOCATION: [Isoform smARF]: Mitochondrion {ECO:0000269|PubMed:16713577}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":92,"datasource_scores":[{"id":"europepmc","score":0.06991204172533642}],"score":0.008500336657748143,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000012061","exclusion_id":"X-ENSG00000012061","identifiers":{"approved_symbol":"ERCC1","ensembl_gene_id":"ENSG00000012061"},"preferred_label":"ERCC1","reconciliation":{"canonical_uniprot_accessions":["P07992"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P07992","entry_name":"ERCC1_HUMAN","gene_names":"ERCC1","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:24036546}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:24036546}. Nucleus {ECO:0000269|PubMed:24036546}.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus {ECO:0000269|PubMed:24036546}.; SUBCELLULAR LOCATION: [Isoform 4]: Nucleus {ECO:0000269|PubMed:24036546}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":93,"datasource_scores":[{"id":"europepmc","score":0.0697431720593332}],"score":0.008479804443598991,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000106541","exclusion_id":"X-ENSG00000106541","identifiers":{"approved_symbol":"AGR2","ensembl_gene_id":"ENSG00000106541"},"preferred_label":"AGR2","reconciliation":{"canonical_uniprot_accessions":["O95994"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"O95994","entry_name":"AGR2_HUMAN","gene_names":"AGR2 AG2 UNQ515/PRO1030","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"SIGNAL 1..20; /evidence=\"ECO:0000269|PubMed:15340161\"","subcellular_location":"SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15834940}. Endoplasmic reticulum {ECO:0000250|UniProtKB:O88312}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":94,"datasource_scores":[{"id":"europepmc","score":0.06945158086292398}],"score":0.008444350989877074,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000117394","identifiers":{"approved_symbol":"SLC2A1","ensembl_gene_id":"ENSG00000117394"},"preferred_label":"SLC2A1","reconciliation":{"canonical_uniprot_accessions":["P11166"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000117394","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P11166","entry_name":"GTR1_HUMAN","gene_names":"SLC2A1 GLUT1","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18245775, ECO:0000269|PubMed:19449892, ECO:0000269|PubMed:23219802, ECO:0000269|PubMed:24847886, ECO:0000269|PubMed:25982116, ECO:0000269|PubMed:30197081}; Multi-pass membrane protein {ECO:0000255}. Melanosome {ECO:0000269|PubMed:17081065}. Photoreceptor inner segment {ECO:0000250|UniProtKB:P17809}. Note=Localizes primarily at the cell surface (PubMed:18245775, PubMed:19449892, PubMed:23219802, PubMed:24847886, PubMed:25982116). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). {ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:18245775, ECO:0000269|PubMed:19449892, ECO:0000269|PubMed:23219802, ECO:0000269|PubMed:24847886, ECO:0000269|PubMed:25982116}.","topological_domain":"TOPO_DOM 1..11; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:24847886\"; TOPO_DOM 34..66; /note=\"Extracellular\"; /evidence=\"ECO:0000269|PubMed:24847886\"; TOPO_DOM 88..90; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:24847886\"; TOPO_DOM 113..120; /note=\"Extracellular\"; /evidence=\"ECO:0000269|PubMed:24847886\"; TOPO_DOM 145..155; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:24847886\"; TOPO_DOM 177..185; /note=\"Extracellular\"; /evidence=\"ECO:0000269|PubMed:24847886\"; TOPO_DOM 207..271; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:24847886\"; TOPO_DOM 294..306; /note=\"Extracellular\"; /evidence=\"ECO:0000269|PubMed:24847886\"; TOPO_DOM 329..334; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:24847886\"; TOPO_DOM 356..365; /note=\"Extracellular\"; /evidence=\"ECO:0000269|PubMed:24847886\"; TOPO_DOM 389..401; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:24847886\"; TOPO_DOM 423..429; /note=\"Extracellular\"; /evidence=\"ECO:0000269|PubMed:24847886\"; TOPO_DOM 451..492; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:24847886\"","transmembrane":"TRANSMEM 12..33; /note=\"Helical; Name=1\"; TRANSMEM 67..87; /note=\"Helical; Name=2\"; TRANSMEM 91..112; /note=\"Helical; Name=3\"; TRANSMEM 121..144; /note=\"Helical; Name=4\"; TRANSMEM 156..176; /note=\"Helical; Name=5\"; TRANSMEM 186..206; /note=\"Helical; Name=6\"; TRANSMEM 272..293; /note=\"Helical; Name=7\"; TRANSMEM 307..328; /note=\"Helical; Name=8\"; TRANSMEM 335..355; /note=\"Helical; Name=9\"; TRANSMEM 366..388; /note=\"Helical; Name=10\"; TRANSMEM 402..422; /note=\"Helical; Name=11\"; TRANSMEM 430..450; /note=\"Helical; Name=12\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":95,"datasource_scores":[{"id":"europepmc","score":0.06839221473130737}],"score":0.008315546730405791,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000147162","identifiers":{"approved_symbol":"OGT","ensembl_gene_id":"ENSG00000147162"},"preferred_label":"OGT","reconciliation":{"canonical_uniprot_accessions":["O15294"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000147162","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"O15294","entry_name":"OGT1_HUMAN","gene_names":"OGT","lipidation":"","provisional_surface_signal":"plasma-membrane-annotation","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26678539, ECO:0000269|PubMed:27713473}. Cytoplasm {ECO:0000269|PubMed:26678539, ECO:0000269|PubMed:27713473}. Note=Predominantly localizes to the nucleus (PubMed:26678539). Translocates into the nucleus via association with importin KPNA1 (PubMed:27713473). {ECO:0000269|PubMed:26678539, ECO:0000269|PubMed:27713473}.; SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion {ECO:0000269|PubMed:20824293}. Membrane {ECO:0000269|PubMed:20824293}. Note=Associates with the mitochondrial inner membrane. {ECO:0000269|PubMed:20824293}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:21285374}. Nucleus {ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:21285374}. Cell membrane {ECO:0000250|UniProtKB:P56558}. Mitochondrion membrane {ECO:0000250|UniProtKB:P56558}. Cell projection {ECO:0000250|UniProtKB:P56558}. Note=Mostly in the nucleus. Retained in the nucleus via interaction with HCFC1 (PubMed:21285374). After insulin induction, translocated from the nucleus to the cell membrane via phosphatidylinositide binding. Colocalizes with AKT1 at the plasma membrane. TRAK1 recruits this protein to mitochondria. In the absence of TRAK1, localizes in cytosol and nucleus (By similarity). {ECO:0000250|UniProtKB:P56558, ECO:0000269|PubMed:21285374}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000303|PubMed:31527085}. Nucleus {ECO:0000303|PubMed:31527085}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"plasma-membrane-annotation","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":96,"datasource_scores":[{"id":"europepmc","score":0.06839221473130737}],"score":0.008315546730405791,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000164850","identifiers":{"approved_symbol":"GPER1","ensembl_gene_id":"ENSG00000164850"},"preferred_label":"GPER1","reconciliation":{"canonical_uniprot_accessions":["Q99527"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000164850","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q99527","entry_name":"GPER1_HUMAN","gene_names":"GPER1 CEPR CMKRL2 DRY12 GPER GPR30","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus. Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Early endosome. Recycling endosome. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi network. Endoplasmic reticulum membrane {ECO:0000269|PubMed:18566127}; Multi-pass membrane protein. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, axon {ECO:0000250}. Postsynaptic density {ECO:0000250}. Mitochondrion membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Colocalized with BSN to the active zone of presynaptic density. Colocalized with DLG4/PSD95 and neurabin-2 PPP1R9B in neuronal synaptosomes (By similarity). Endocytosed in a agonist- and arrestin-independent manner. Colocalized with RAMP3 and clathrin-coated pits at the plasma membrane. Colocalized with transferrin receptor at the plasma membrane and perinuclear region. Accumulated and colocalized with RAB11 proteins in recycling endosomes and trans-Golgi network (TGN), but does neither recycle back to the cell surface nor traffics to late endosome or lysosome. Colocalized with calnexin in the endoplasmic reticulum. Traffics to intracellular sites via cytokeratin intermediate filaments like KRT7 and KRT8 after constitutive endocytosis in epithelial cells. Colocalized with EGFR in the nucleus of agonist-induced cancer-associated fibroblasts (CAF). {ECO:0000250}.","topological_domain":"TOPO_DOM 1..62; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 85..96; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 121..132; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 154..175; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 195..220; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 237..259; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 281..306; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 328..375; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 63..84; /note=\"Helical; Name=1\"; /evidence=\"ECO:0000255\"; TRANSMEM 97..120; /note=\"Helical; Name=2\"; /evidence=\"ECO:0000255\"; TRANSMEM 133..153; /note=\"Helical; Name=3\"; /evidence=\"ECO:0000255\"; TRANSMEM 176..194; /note=\"Helical; Name=4\"; /evidence=\"ECO:0000255\"; TRANSMEM 221..236; /note=\"Helical; Name=5\"; /evidence=\"ECO:0000255\"; TRANSMEM 260..280; /note=\"Helical; Name=6\"; /evidence=\"ECO:0000255\"; TRANSMEM 307..327; /note=\"Helical; Name=7\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":97,"datasource_scores":[{"id":"europepmc","score":0.06839221473130737}],"score":0.008315546730405791,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000149311","exclusion_id":"X-ENSG00000149311","identifiers":{"approved_symbol":"ATM","ensembl_gene_id":"ENSG00000149311"},"preferred_label":"ATM","reconciliation":{"canonical_uniprot_accessions":["Q13315"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q13315","entry_name":"ATM_HUMAN","gene_names":"ATM","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9050866, ECO:0000269|PubMed:9150358}. Cytoplasmic vesicle {ECO:0000269|PubMed:9050866, ECO:0000269|PubMed:9150358}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q62388}. Peroxisome matrix {ECO:0000269|PubMed:26344566}. Note=Primarily nuclear (PubMed:9050866, PubMed:9150358). Found also in endocytic vesicles in association with beta-adaptin (PubMed:9707615). Translocated to peroxisomes in response to reactive oxygen species (ROS) by PEX5 (PubMed:26344566). {ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:9050866, ECO:0000269|PubMed:9150358, ECO:0000269|PubMed:9707615}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":98,"datasource_scores":[{"id":"europepmc","score":0.06839221473130737}],"score":0.008315546730405791,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000081237","identifiers":{"approved_symbol":"PTPRC","ensembl_gene_id":"ENSG00000081237"},"preferred_label":"PTPRC","reconciliation":{"canonical_uniprot_accessions":["P08575"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000081237","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P08575","entry_name":"PTPRC_HUMAN","gene_names":"PTPRC CD45","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..25","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12676959, ECO:0000269|PubMed:22174689}; Single-pass type I membrane protein {ECO:0000255}. Membrane raft {ECO:0000269|PubMed:12676959}. Synapse {ECO:0000269|PubMed:35767951}. Note=Colocalized with DPP4 in membrane rafts. {ECO:0000269|PubMed:12676959}.","topological_domain":"TOPO_DOM 26..577; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 599..1306; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 578..598; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":99,"datasource_scores":[{"id":"europepmc","score":0.06772855694391468}],"score":0.008234855128799632,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000118046","exclusion_id":"X-ENSG00000118046","identifiers":{"approved_symbol":"STK11","ensembl_gene_id":"ENSG00000118046"},"preferred_label":"STK11","reconciliation":{"canonical_uniprot_accessions":["Q15831"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q15831","entry_name":"STK11_HUMAN","gene_names":"STK11 LKB1 PJS","lipidation":"LIPID 418; /note=\"S-palmitoyl cysteine\"; /evidence=\"ECO:0000250\"; LIPID 430; /note=\"S-farnesyl cysteine\"; /evidence=\"ECO:0000250\"","provisional_surface_signal":"membrane-only","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18854309}. Cytoplasm {ECO:0000269|PubMed:18854309}. Membrane {ECO:0000250|UniProtKB:Q9WTK7}. Mitochondrion {ECO:0000269|PubMed:11430832}. Late endosome {ECO:0000250|UniProtKB:Q9WTK7}. Note=A small fraction localizes at membranes (By similarity). Relocates to the cytoplasm when bound to STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) (PubMed:18854309). Translocates to the mitochondrion during apoptosis. PTEN promotes cytoplasmic localization (PubMed:11430832). Translocates to late endosomes in response to calorie restriction (By similarity). {ECO:0000250|UniProtKB:Q9WTK7, ECO:0000269|PubMed:11430832, ECO:0000269|PubMed:18854309}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:23612973}. Cytoplasm {ECO:0000269|PubMed:23612973}. Note=Predominantly nuclear, but translocates to the cytoplasm in response to metformin or peroxynitrite treatment. {ECO:0000269|PubMed:23612973}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"membrane-only","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":100,"datasource_scores":[{"id":"europepmc","score":0.06737899673528801}],"score":0.00819235344551089,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000148400","identifiers":{"approved_symbol":"NOTCH1","ensembl_gene_id":"ENSG00000148400"},"preferred_label":"NOTCH1","reconciliation":{"canonical_uniprot_accessions":["P46531"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000148400","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P46531","entry_name":"NOTC1_HUMAN","gene_names":"NOTCH1 TAN1","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..18; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:38016980}; Single-pass type I membrane protein {ECO:0000305|PubMed:30598546}. Late endosome membrane {ECO:0000269|PubMed:22778262}; Single-pass type I membrane protein {ECO:0000305|PubMed:30598546}. Note=Non-activated receptor is targeted for lysosomal degradation via the endosomal pathway; transport from late endosomes to lysosomes requires deubiquitination by USP12. {ECO:0000269|PubMed:22778262}.; SUBCELLULAR LOCATION: [Notch 1 intracellular domain]: Nucleus {ECO:0000250|UniProtKB:Q01705}. Note=Following proteolytical processing NICD is translocated to the nucleus. Nuclear location may require MEGF10. {ECO:0000250|UniProtKB:Q01705}.","topological_domain":"TOPO_DOM 19..1735; /note=\"Extracellular\"; /evidence=\"ECO:0000305|PubMed:28439555, ECO:0000305|PubMed:30598546\"; TOPO_DOM 1757..2555; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000305|PubMed:28439555, ECO:0000305|PubMed:30598546\"","transmembrane":"TRANSMEM 1736..1756; /note=\"Helical\"; /evidence=\"ECO:0000269|PubMed:28439555, ECO:0000269|PubMed:30598546\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":101,"datasource_scores":[{"id":"europepmc","score":0.06687238773727831}],"score":0.00813075680306344,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000132383","exclusion_id":"X-ENSG00000132383","identifiers":{"approved_symbol":"RPA1","ensembl_gene_id":"ENSG00000132383"},"preferred_label":"RPA1","reconciliation":{"canonical_uniprot_accessions":["P27694"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P27694","entry_name":"RFA1_HUMAN","gene_names":"RPA1 REPA1 RPA70","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:17959650}. Nucleus, PML body {ECO:0000269|PubMed:17959650}. Note=Enriched in PML bodies in cells displaying alternative lengthening of their telomeres. {ECO:0000269|PubMed:17959650}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":102,"datasource_scores":[{"id":"europepmc","score":0.06687238773727831}],"score":0.00813075680306344,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000134853","identifiers":{"approved_symbol":"PDGFRA","ensembl_gene_id":"ENSG00000134853"},"preferred_label":"PDGFRA","query_expansion_seeds":[{"category":"stroma-and-vasculature","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["P16234"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000134853","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P16234","entry_name":"PGFRA_HUMAN","gene_names":"PDGFRA PDGFR2 RHEPDGFRA","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..23","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14644164, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:8188664}; Single-pass type I membrane protein {ECO:0000269|PubMed:14644164, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:8188664}. Cell projection, cilium {ECO:0000250|UniProtKB:P26618}. Golgi apparatus {ECO:0000250|UniProtKB:P26618}.","topological_domain":"TOPO_DOM 24..528; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 550..1089; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 529..549; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":103,"datasource_scores":[{"id":"europepmc","score":0.06687238773727831}],"score":0.00813075680306344,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000113721","identifiers":{"approved_symbol":"PDGFRB","ensembl_gene_id":"ENSG00000113721"},"preferred_label":"PDGFRB","query_expansion_seeds":[{"category":"stroma-and-vasculature","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["P09619"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000113721","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P09619","entry_name":"PGFRB_HUMAN","gene_names":"PDGFRB PDGFR PDGFR1","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..32; /evidence=\"ECO:0000269|PubMed:15340161\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle. Lysosome lumen. Note=After ligand binding, the autophosphorylated receptor is ubiquitinated and internalized, leading to its degradation.","topological_domain":"TOPO_DOM 33..532; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 554..1106; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 533..553; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":104,"datasource_scores":[{"id":"europepmc","score":0.06535256074324927}],"score":0.00794596687572109,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000136997","exclusion_id":"X-ENSG00000136997","identifiers":{"approved_symbol":"MYC","ensembl_gene_id":"ENSG00000136997"},"preferred_label":"MYC","reconciliation":{"canonical_uniprot_accessions":["P01106"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P01106","entry_name":"MYC_HUMAN","gene_names":"MYC BHLHE39","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:17558397}. Nucleus, nucleolus {ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:38225354}. Nucleus {ECO:0000269|PubMed:22719065, ECO:0000269|PubMed:38225354}. Cytoplasm {ECO:0000269|PubMed:22719065}. Chromosome {ECO:0000269|PubMed:30158517}. Note=Association with chromatin is reduced by hyperphosphorylation (PubMed:30158517). Localization to the nucleolus is dependent on HEATR1 (PubMed:38225354). {ECO:0000269|PubMed:30158517, ECO:0000269|PubMed:38225354}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":105,"datasource_scores":[{"id":"europepmc","score":0.06535256074324927}],"score":0.00794596687572109,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000168003","identifiers":{"approved_symbol":"SLC3A2","ensembl_gene_id":"ENSG00000168003"},"preferred_label":"SLC3A2","reconciliation":{"canonical_uniprot_accessions":["P08195"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000168003","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P08195","entry_name":"4F2_HUMAN","gene_names":"SLC3A2 MDU1","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:11742812}. Cell membrane {ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:15769744, ECO:0000269|PubMed:16496379, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:3476959, ECO:0000269|PubMed:3480538, ECO:0000269|PubMed:36028562, ECO:0000269|PubMed:37918808, ECO:0000269|PubMed:9829974}; Single-pass type II membrane protein {ECO:0000269|PubMed:30867591}. Cell junction {ECO:0000250|UniProtKB:P10852}. Lysosome membrane {ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:40280132}. Melanosome {ECO:0000269|PubMed:17081065}. Basolateral cell membrane {ECO:0000250|UniProtKB:P10852}. Note=Localized at the plasma membrane when associated with SLC7A5/LAT1 or SLC7A8/LAT2 (PubMed:11311135, PubMed:9751058). Localized to the apical membrane of placental syncytiotrophoblastic cells (PubMed:11742812). Recruited to lysosomes by LAPTM4B (PubMed:25998567). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Located selectively at cell-cell adhesion sites (By similarity). Colocalized with SLC7A8/LAT2 at the basolateral membrane of kidney proximal tubules and small intestine epithelia. Expressed in both luminal and abluminal membranes of brain capillary endothelial cells (By similarity). {ECO:0000250|UniProtKB:P10852, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:9751058}.","topological_domain":"TOPO_DOM 2..83; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:11121428, ECO:0000269|PubMed:30867591\"; TOPO_DOM 105..529; /note=\"Extracellular\"; /evidence=\"ECO:0000269|PubMed:11121428, ECO:0000269|PubMed:30867591\"","transmembrane":"TRANSMEM 84..104; /note=\"Helical; Signal-anchor for type II membrane protein\"; /evidence=\"ECO:0000269|PubMed:30867591\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":106,"datasource_scores":[{"id":"europepmc","score":0.06535256074324927}],"score":0.00794596687572109,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000073756","exclusion_id":"X-ENSG00000073756","identifiers":{"approved_symbol":"PTGS2","ensembl_gene_id":"ENSG00000073756"},"preferred_label":"PTGS2","reconciliation":{"canonical_uniprot_accessions":["P35354"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P35354","entry_name":"PGH2_HUMAN","gene_names":"PTGS2 COX2","lipidation":"","provisional_surface_signal":"membrane-only","signal_peptide":"SIGNAL 1..17; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Microsome membrane {ECO:0000269|PubMed:9545330}; Peripheral membrane protein. Endoplasmic reticulum membrane {ECO:0000269|PubMed:9545330}; Peripheral membrane protein. Nucleus inner membrane {ECO:0000269|PubMed:9545330}; Peripheral membrane protein. Nucleus outer membrane {ECO:0000269|PubMed:9545330}; Peripheral membrane protein. Note=Detected on the lumenal side of the endoplasmic reticulum and nuclear envelope. {ECO:0000269|PubMed:9545330}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"membrane-only","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":107,"datasource_scores":[{"id":"europepmc","score":0.06383273374922022}],"score":0.007761176948378739,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000188404","identifiers":{"approved_symbol":"SELL","ensembl_gene_id":"ENSG00000188404"},"preferred_label":"SELL","reconciliation":{"canonical_uniprot_accessions":["P14151"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000188404","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P14151","entry_name":"LYAM1_HUMAN","gene_names":"SELL LNHR LYAM1","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..28","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:2509939, ECO:0000269|PubMed:2663882, ECO:0000269|PubMed:28011641}; Single-pass type I membrane protein {ECO:0000305|PubMed:2663882}.","topological_domain":"TOPO_DOM 39..332; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 356..372; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 333..355; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":108,"datasource_scores":[{"id":"europepmc","score":0.06383273374922022}],"score":0.007761176948378739,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000101346","exclusion_id":"X-ENSG00000101346","identifiers":{"approved_symbol":"POFUT1","ensembl_gene_id":"ENSG00000101346"},"preferred_label":"POFUT1","reconciliation":{"canonical_uniprot_accessions":["Q9H488"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q9H488","entry_name":"OFUT1_HUMAN","gene_names":"POFUT1 FUT12 KIAA0180","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"SIGNAL 1..26; 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Nucleus {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15799969, ECO:0000269|PubMed:16156666, ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:19218245, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:21145499, ECO:0000269|PubMed:22781750}. Note=Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 (PubMed:15799969, PubMed:21145499). Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 (PubMed:16751101, PubMed:19289081). Co-localizes with LEMD3 at the nucleus inner membrane (PubMed:15601644). MAPK-mediated phosphorylation appears to have no effect on nuclear import (PubMed:19218245). PDPK1 prevents its nuclear translocation in response to TGF-beta (PubMed:17327236). Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm of the inner cell mass at the blastocyst stage (By similarity). {ECO:0000250|UniProtKB:Q8BUN5, ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15799969, ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:19218245, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:21145499}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"membrane-only","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":111,"datasource_scores":[{"id":"europepmc","score":0.06383273374922022}],"score":0.007761176948378737,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000174697","exclusion_id":"X-ENSG00000174697","identifiers":{"approved_symbol":"LEP","ensembl_gene_id":"ENSG00000174697"},"preferred_label":"LEP","reconciliation":{"canonical_uniprot_accessions":["P41159"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P41159","entry_name":"LEP_HUMAN","gene_names":"LEP OB OBS","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"SIGNAL 1..21; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:25232147}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":112,"datasource_scores":[{"id":"europepmc","score":0.06370608149971779}],"score":0.007745777787766876,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000143924","exclusion_id":"X-ENSG00000143924","identifiers":{"approved_symbol":"EML4","ensembl_gene_id":"ENSG00000143924"},"preferred_label":"EML4","reconciliation":{"canonical_uniprot_accessions":["Q9HC35"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q9HC35","entry_name":"EMAL4_HUMAN","gene_names":"EML4 C2orf2 EMAPL4","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:31409757, ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:16890222}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:25789526}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:25789526}. Midbody {ECO:0000269|PubMed:25789526}. 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Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:12643545}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":136,"datasource_scores":[{"id":"europepmc","score":0.06079307976116211}],"score":0.0073915970936940375,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000160862","exclusion_id":"X-ENSG00000160862","identifiers":{"approved_symbol":"AZGP1","ensembl_gene_id":"ENSG00000160862"},"preferred_label":"AZGP1","reconciliation":{"canonical_uniprot_accessions":["P25311"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P25311","entry_name":"ZA2G_HUMAN","gene_names":"AZGP1 ZAG ZNGP1","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"SIGNAL 1..20; 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/evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22615920}; Multi-pass membrane protein {ECO:0000269|PubMed:22615920}.","topological_domain":"TOPO_DOM 25..567; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 589..598; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 620..644; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 666..687; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 709..727; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 749..774; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 796..809; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 831..967; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 568..588; /note=\"Helical; Name=1\"; /evidence=\"ECO:0000255\"; TRANSMEM 599..619; /note=\"Helical; Name=2\"; /evidence=\"ECO:0000255\"; TRANSMEM 645..665; /note=\"Helical; Name=3\"; /evidence=\"ECO:0000255\"; TRANSMEM 688..708; /note=\"Helical; Name=4\"; /evidence=\"ECO:0000255\"; TRANSMEM 728..748; /note=\"Helical; Name=5\"; /evidence=\"ECO:0000255\"; TRANSMEM 775..795; /note=\"Helical; Name=6\"; /evidence=\"ECO:0000255\"; TRANSMEM 810..830; /note=\"Helical; Name=7\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":138,"datasource_scores":[{"id":"europepmc","score":0.06079307976116211}],"score":0.0073915970936940375,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000145703","identifiers":{"approved_symbol":"IQGAP2","ensembl_gene_id":"ENSG00000145703"},"preferred_label":"IQGAP2","reconciliation":{"canonical_uniprot_accessions":["Q13576"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"localization-unresolved","reasons":["The canonical reviewed UniProt entry has no decisive localization annotation."],"state":"unresolved","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"unresolved","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q13576","entry_name":"IQGA2_HUMAN","gene_names":"IQGAP2","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":139,"datasource_scores":[{"id":"europepmc","score":0.06079307976116211}],"score":0.0073915970936940375,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000089280","exclusion_id":"X-ENSG00000089280","identifiers":{"approved_symbol":"FUS","ensembl_gene_id":"ENSG00000089280"},"preferred_label":"FUS","reconciliation":{"canonical_uniprot_accessions":["P35637"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P35637","entry_name":"FUS_HUMAN","gene_names":"FUS TLS","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19251627, ECO:0000269|PubMed:19251628, ECO:0000269|PubMed:24204307, ECO:0000269|PubMed:25453086, ECO:0000269|PubMed:30354839}. 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Chromosome {ECO:0000269|PubMed:24065767}. Note=Localizes to transcription start sites. {ECO:0000269|PubMed:24065767}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":141,"datasource_scores":[{"id":"europepmc","score":0.05927325276713306}],"score":0.007206807166351686,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000091513","exclusion_id":"X-ENSG00000091513","identifiers":{"approved_symbol":"TF","ensembl_gene_id":"ENSG00000091513"},"preferred_label":"TF","reconciliation":{"canonical_uniprot_accessions":["P02787"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P02787","entry_name":"TRFE_HUMAN","gene_names":"TF PRO1400","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"SIGNAL 1..19; /evidence=\"ECO:0000269|PubMed:6833213\"","subcellular_location":"SUBCELLULAR LOCATION: Secreted.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":142,"datasource_scores":[{"id":"europepmc","score":0.057753425773104}],"score":0.007022017239009335,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000198793","exclusion_id":"X-ENSG00000198793","identifiers":{"approved_symbol":"MTOR","ensembl_gene_id":"ENSG00000198793"},"preferred_label":"MTOR","reconciliation":{"canonical_uniprot_accessions":["P42345"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-cytoplasmic-face-or-peripheral-membrane","reasons":["Reviewed UniProt places the canonical protein on the cytoplasmic face or as a peripheral membrane protein without an extracellular domain."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P42345","entry_name":"MTOR_HUMAN","gene_names":"MTOR FRAP FRAP1 FRAP2 RAFT1 RAPT1","lipidation":"","provisional_surface_signal":"plasma-membrane-annotation","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:18497260, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:29750193, ECO:0000269|PubMed:30956113, ECO:0000269|PubMed:31112131, ECO:0000269|PubMed:31601764, ECO:0000269|PubMed:37057673}; Peripheral membrane protein {ECO:0000269|PubMed:30956113, ECO:0000269|PubMed:31112131}; Cytoplasmic side {ECO:0000269|PubMed:30956113, ECO:0000269|PubMed:31112131}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:14578359}; Peripheral membrane protein {ECO:0000269|PubMed:14578359}; Cytoplasmic side {ECO:0000269|PubMed:14578359}. Golgi apparatus membrane {ECO:0000269|PubMed:14578359}; Peripheral membrane protein {ECO:0000269|PubMed:14578359}; Cytoplasmic side {ECO:0000269|PubMed:14578359}. Cell membrane {ECO:0000269|PubMed:21867682}; Peripheral membrane protein {ECO:0000269|PubMed:14578359}. Mitochondrion outer membrane {ECO:0000269|PubMed:11930000, ECO:0000269|PubMed:14578359}; Peripheral membrane protein {ECO:0000269|PubMed:11930000, ECO:0000269|PubMed:14578359}; Cytoplasmic side {ECO:0000269|PubMed:11930000, ECO:0000269|PubMed:14578359}. Cytoplasm {ECO:0000269|PubMed:11930000, ECO:0000269|PubMed:18497260}. Nucleus {ECO:0000250|UniProtKB:Q9JLN9}. Nucleus, PML body {ECO:0000250|UniProtKB:Q9JLN9}. Microsome membrane {ECO:0000269|PubMed:9434772}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:27623384}. Note=Shuttles between cytoplasm and nucleus. Accumulates in the nucleus in response to hypoxia (By similarity). Targeting to lysosomes depends on amino acid availability and RRAGA and RRAGB (PubMed:18497260, PubMed:20381137). Lysosome targeting also depends on interaction with MEAK7. Translocates to the lysosome membrane in the presence of TM4SF5 (PubMed:30956113). 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Recruited to desmosomes at the initial assembly phase and also accumulates progressively at mature desmosome cell-cell junctions (PubMed:25208567, PubMed:29999492). Localizes to cell-cell contacts as keratinocyte differentiation progresses (By similarity). {ECO:0000250|UniProtKB:P09803, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:29999492}.; SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:34742300}. Note=(Microbial infection) Proteolytically cleaved at the cell membrane upon H.pylori infection. {ECO:0000269|PubMed:34742300}.","topological_domain":"TOPO_DOM 155..709; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 731..882; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 710..730; /note=\"Helical\"; /evidence=\"ECO:0000255\""},{"accession":"Q9UM11","entry_name":"FZR1_HUMAN","gene_names":"FZR1 CDH1 FYR FZR KIAA1242","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:34788397}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":153,"datasource_scores":[{"id":"europepmc","score":0.051674117796987794}],"score":0.006282857529639931,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000125398","exclusion_id":"X-ENSG00000125398","identifiers":{"approved_symbol":"SOX9","ensembl_gene_id":"ENSG00000125398"},"preferred_label":"SOX9","reconciliation":{"canonical_uniprot_accessions":["P48436"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P48436","entry_name":"SOX9_HUMAN","gene_names":"SOX9","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:8640233}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":154,"datasource_scores":[{"id":"europepmc","score":0.050368329212080405}],"score":0.006124091710452952,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000142208","identifiers":{"approved_symbol":"AKT1","ensembl_gene_id":"ENSG00000142208"},"preferred_label":"AKT1","reconciliation":{"canonical_uniprot_accessions":["P31749"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"extracellular-accessibility-unresolved","reasons":["A membrane or cell-surface localization is reported, but extracellular orientation or anchoring is unresolved."],"state":"unresolved","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"unresolved","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P31749","entry_name":"AKT1_HUMAN","gene_names":"AKT1 PKB RAC","lipidation":"","provisional_surface_signal":"plasma-membrane-annotation","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P31750}. 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TRANSMEM 94..115; /note=\"Helical; Name=3\"; /evidence=\"ECO:0000269|PubMed:40044865, ECO:0000269|PubMed:40101766, ECO:0007744|PDB:8YW6, ECO:0007744|PDB:8YW8, ECO:0007744|PDB:8YW9, ECO:0007744|PDB:9KNW, ECO:0007744|PDB:9KNX, ECO:0007744|PDB:9KNY, ECO:0007744|PDB:9MNW, ECO:0007744|PDB:9MNX, ECO:0007744|PDB:9MNY, ECO:0007744|PDB:9MNZ, ECO:0007744|PDB:9MO0\""}],"provisional_surface_signal":"membrane-only","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":172,"datasource_scores":[{"id":"europepmc","score":0.04255515583281348}],"score":0.0051741179655858255,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000060762","exclusion_id":"X-ENSG00000060762","identifiers":{"approved_symbol":"MPC1","ensembl_gene_id":"ENSG00000060762"},"preferred_label":"MPC1","reconciliation":{"canonical_uniprot_accessions":["Q9Y5U8"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q9Y5U8","entry_name":"MPC1_HUMAN","gene_names":"MPC1 BRP44L CGI-129 HSPC040 PNAS-115","lipidation":"","provisional_surface_signal":"membrane-only","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:22628558, ECO:0000269|PubMed:26253029}; 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Golgi apparatus. Golgi apparatus membrane; Lipid-anchor. Note=The active GTP-bound form is localized most strongly to membranes than the inactive GDP-bound form (By similarity). Shuttles between the plasma membrane and the Golgi apparatus. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Colocalizes with RACK1 to the perinuclear region.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"plasma-membrane-annotation","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":185,"datasource_scores":[{"id":"europepmc","score":0.039346632178752144}],"score":0.004784005896751974,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000086548","identifiers":{"approved_symbol":"CEACAM6","ensembl_gene_id":"ENSG00000086548"},"preferred_label":"CEACAM6","query_expansion_seeds":[{"category":"lineage-and-tumor-antigens","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["P40199"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt records an integral or GPI-anchored membrane form."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000086548","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P40199","entry_name":"CEAM6_HUMAN","gene_names":"CEACAM6 NCA","lipidation":"LIPID 320; /note=\"GPI-anchor amidated glycine\"; /evidence=\"ECO:0000250|UniProtKB:P31997\"","provisional_surface_signal":"plasma-membrane-annotation","signal_peptide":"SIGNAL 1..34; /evidence=\"ECO:0000269|PubMed:15340161\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:2317824}. Apical cell membrane {ECO:0000269|PubMed:10436421}. Cell surface {ECO:0000269|PubMed:1378450, ECO:0000269|PubMed:16204051, ECO:0000269|PubMed:2317824, ECO:0000269|PubMed:8776764, ECO:0000305|PubMed:2803308}. Note=Localized to the apical glycocalyx surface. {ECO:0000269|PubMed:10436421}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"plasma-membrane-annotation","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":186,"datasource_scores":[{"id":"europepmc","score":0.03926219734575053}],"score":0.004773739789677399,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000160182","exclusion_id":"X-ENSG00000160182","identifiers":{"approved_symbol":"TFF1","ensembl_gene_id":"ENSG00000160182"},"preferred_label":"TFF1","reconciliation":{"canonical_uniprot_accessions":["P04155"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P04155","entry_name":"TFF1_HUMAN","gene_names":"TFF1 BCEI PS2","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"SIGNAL 1..24; /evidence=\"ECO:0000269|PubMed:15340161, ECO:0000269|PubMed:15924415, ECO:0000269|PubMed:16308573, ECO:0000269|PubMed:3146413, ECO:0000269|PubMed:3261981\"","subcellular_location":"SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15924415, ECO:0000269|PubMed:3041593}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":187,"datasource_scores":[{"id":"europepmc","score":0.037995674850726316}],"score":0.004619748183558772,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000015475","exclusion_id":"X-ENSG00000015475","identifiers":{"approved_symbol":"BID","ensembl_gene_id":"ENSG00000015475"},"preferred_label":"BID","reconciliation":{"canonical_uniprot_accessions":["P55957"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P55957","entry_name":"BID_HUMAN","gene_names":"BID","lipidation":"","provisional_surface_signal":"membrane-only","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14583606}. Mitochondrion membrane {ECO:0000269|PubMed:14583606}. Mitochondrion outer membrane {ECO:0000269|PubMed:29531808}. Note=When uncleaved, it is predominantly cytoplasmic. {ECO:0000269|PubMed:14583606}.; SUBCELLULAR LOCATION: [BH3-interacting domain death agonist p15]: Mitochondrion membrane {ECO:0000269|PubMed:9727491}. Note=Translocates to mitochondria following cleavage. {ECO:0000269|PubMed:9727491}.; SUBCELLULAR LOCATION: [BH3-interacting domain death agonist p13]: Mitochondrion membrane {ECO:0000250|UniProtKB:P70444}. Note=Associated with the mitochondrial membrane. {ECO:0000250|UniProtKB:P70444}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:14583606}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:14583606}.; SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion membrane {ECO:0000269|PubMed:14583606}. Note=A significant proportion of isoform 2 localizes to mitochondria, it may be cleaved constitutively. {ECO:0000269|PubMed:14583606}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"membrane-only","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":188,"datasource_scores":[{"id":"europepmc","score":0.037995674850726316}],"score":0.004619748183558772,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000163513","identifiers":{"approved_symbol":"TGFBR2","ensembl_gene_id":"ENSG00000163513"},"preferred_label":"TGFBR2","reconciliation":{"canonical_uniprot_accessions":["P37173"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000163513","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P37173","entry_name":"TGFR2_HUMAN","gene_names":"TGFBR2","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..22; /evidence=\"ECO:0000269|PubMed:15340161\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1310899, ECO:0000269|PubMed:25893292}; Single-pass type I membrane protein {ECO:0000269|PubMed:1310899}. Membrane raft {ECO:0000269|PubMed:25893292}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000269|PubMed:34568316}.","topological_domain":"TOPO_DOM 23..166; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 188..567; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 167..187; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":189,"datasource_scores":[{"id":"europepmc","score":0.037995674850726316}],"score":0.004619748183558772,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000085741","identifiers":{"approved_symbol":"WNT11","ensembl_gene_id":"ENSG00000085741"},"preferred_label":"WNT11","reconciliation":{"canonical_uniprot_accessions":["O96014"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"extracellular-matrix-retention-accessibility-unresolved","reasons":["Canonical reviewed UniProt explicitly reports extracellular-matrix localization, which is within the broad extracellular target scope.","Disease-site retention, extracellular accessibility, and cell of origin require review before retaining this as an actionable matrix target; it is not an intracellular or soluble-only exclusion."],"state":"unresolved","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"unresolved","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"O96014","entry_name":"WNT11_HUMAN","gene_names":"WNT11","lipidation":"LIPID 215; /note=\"O-palmitoleoyl serine; by PORCN\"; /evidence=\"ECO:0000250|UniProtKB:P56704\"","provisional_surface_signal":"no-signal","signal_peptide":"SIGNAL 1..24; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":190,"datasource_scores":[{"id":"europepmc","score":0.037995674850726316}],"score":0.004619748183558772,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000102882","exclusion_id":"X-ENSG00000102882","identifiers":{"approved_symbol":"MAPK3","ensembl_gene_id":"ENSG00000102882"},"preferred_label":"MAPK3","reconciliation":{"canonical_uniprot_accessions":["P27361"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P27361","entry_name":"MK03_HUMAN","gene_names":"MAPK3 ERK1 PRKM3","lipidation":"","provisional_surface_signal":"membrane-only","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P21708}. Nucleus. Membrane, caveola {ECO:0000250|UniProtKB:P21708}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q63844}. Note=Autophosphorylation at Thr-207 promotes nuclear localization (PubMed:19060905). 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Chromosome, telomere {ECO:0000269|PubMed:21076401}. Nucleus {ECO:0000269|PubMed:24013206, ECO:0000269|PubMed:26833090, ECO:0000305|PubMed:21276791}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:21276791}. 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Cytoplasm {ECO:0000269|PubMed:27558414, ECO:0000269|PubMed:29531808}. Nucleus {ECO:0000269|PubMed:36361894}. Note=Colocalizes with 14-3-3 proteins in the cytoplasm. Under stress conditions, undergoes a conformation change that causes release from JNK-phosphorylated 14-3-3 proteins and translocation to the mitochondrion membrane. 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Recruited to DNA damage sites fowwing interaction with poly-ADP-ribose chains (PubMed:14500814). {ECO:0000269|PubMed:14500814, ECO:0000269|PubMed:28002403}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":234,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000183454","identifiers":{"approved_symbol":"GRIN2A","ensembl_gene_id":"ENSG00000183454"},"preferred_label":"GRIN2A","reconciliation":{"canonical_uniprot_accessions":["Q12879"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000183454","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q12879","entry_name":"NMDE1_HUMAN","gene_names":"GRIN2A NMDAR2A","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..22; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q00959}. Cell membrane {ECO:0000269|PubMed:23933820, ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:27839871, ECO:0000269|PubMed:28095420, ECO:0000269|PubMed:28105280, ECO:0000269|PubMed:28242877, ECO:0000269|PubMed:38538865, ECO:0000269|PubMed:8768735}; Multi-pass membrane protein {ECO:0000269|PubMed:34186027}. Synapse {ECO:0000250|UniProtKB:P35436}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q00959}; Multi-pass membrane protein {ECO:0000269|PubMed:34186027}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P35436}. Note=Expression at the dendrite cell membrane and at synapses is regulated by SORCS2 and the retromer complex. {ECO:0000250|UniProtKB:P35436}.","topological_domain":"TOPO_DOM 23..556; /note=\"Extracellular\"; /evidence=\"ECO:0000269|PubMed:34186027, ECO:0007744|PDB:7EOQ\"; TOPO_DOM 577..600; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:34186027, ECO:0007744|PDB:7EOQ\"; TOPO_DOM 616..625; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:34186027, ECO:0007744|PDB:7EOQ\"; TOPO_DOM 647..814; /note=\"Extracellular\"; /evidence=\"ECO:0000269|PubMed:34186027, ECO:0007744|PDB:7EOQ\"; TOPO_DOM 836..1464; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:34186027, ECO:0007744|PDB:7EOQ\"","transmembrane":"TRANSMEM 557..576; /note=\"Helical\"; /evidence=\"ECO:0000269|PubMed:34186027, ECO:0007744|PDB:7EOQ\"; TRANSMEM 626..646; /note=\"Helical\"; /evidence=\"ECO:0000269|PubMed:34186027, ECO:0007744|PDB:7EOQ\"; TRANSMEM 815..835; /note=\"Helical\"; /evidence=\"ECO:0000269|PubMed:34186027, ECO:0007744|PDB:7EOQ\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":235,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000127954","identifiers":{"approved_symbol":"STEAP4","ensembl_gene_id":"ENSG00000127954"},"preferred_label":"STEAP4","reconciliation":{"canonical_uniprot_accessions":["Q687X5"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt records an integral or GPI-anchored membrane form."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000127954","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q687X5","entry_name":"STEA4_HUMAN","gene_names":"STEAP4 STAMP2 TNFAIP9","lipidation":"","provisional_surface_signal":"plasma-membrane-annotation","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15897894, ECO:0000269|PubMed:18430367}; Multi-pass membrane protein {ECO:0000269|PubMed:30337524}. Golgi apparatus membrane {ECO:0000269|PubMed:15897894}; Multi-pass membrane protein {ECO:0000269|PubMed:30337524}. Early endosome membrane {ECO:0000269|PubMed:15897894}; Multi-pass membrane protein {ECO:0000269|PubMed:30337524}.","topological_domain":"","transmembrane":"TRANSMEM 202..224; /note=\"Helical\"; /evidence=\"ECO:0000269|PubMed:30337524\"; TRANSMEM 236..256; /note=\"Helical\"; /evidence=\"ECO:0000269|PubMed:30337524\"; TRANSMEM 293..313; /note=\"Helical\"; /evidence=\"ECO:0000269|PubMed:30337524\"; TRANSMEM 342..362; /note=\"Helical\"; /evidence=\"ECO:0000269|PubMed:30337524\"; TRANSMEM 381..401; /note=\"Helical\"; /evidence=\"ECO:0000269|PubMed:30337524\"; TRANSMEM 419..439; /note=\"Helical\"; /evidence=\"ECO:0000269|PubMed:30337524\""}],"provisional_surface_signal":"plasma-membrane-annotation","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":236,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000136026","identifiers":{"approved_symbol":"CKAP4","ensembl_gene_id":"ENSG00000136026"},"preferred_label":"CKAP4","reconciliation":{"canonical_uniprot_accessions":["Q07065"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000136026","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q07065","entry_name":"CKAP4_HUMAN","gene_names":"CKAP4","lipidation":"LIPID 100; /note=\"S-palmitoyl cysteine; by ZDHHC2\"; /evidence=\"ECO:0000269|PubMed:18296695, ECO:0000269|PubMed:19144824\"","provisional_surface_signal":"extracellular-topology","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18296695, ECO:0000269|PubMed:19144824}; Single-pass type II membrane protein. Cell membrane {ECO:0000269|PubMed:18296695, ECO:0000269|PubMed:19144824}; Single-pass type II membrane protein. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Note=Translocates to the perinuclear region upon APF-stimulation.","topological_domain":"TOPO_DOM 1..106; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 128..602; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 107..127; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":237,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000140092","identifiers":{"approved_symbol":"FBLN5","ensembl_gene_id":"ENSG00000140092"},"preferred_label":"FBLN5","reconciliation":{"canonical_uniprot_accessions":["Q9UBX5"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"extracellular-matrix-retention-accessibility-unresolved","reasons":["Canonical reviewed UniProt explicitly reports extracellular-matrix localization, which is within the broad extracellular target scope.","Disease-site retention, extracellular accessibility, and cell of origin require review before retaining this as an actionable matrix target; it is not an intracellular or soluble-only exclusion."],"state":"unresolved","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"unresolved","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q9UBX5","entry_name":"FBLN5_HUMAN","gene_names":"FBLN5 DANCE UNQ184/PRO210","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"SIGNAL 1..23; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16652333, ECO:0000269|PubMed:17035250, ECO:0000269|PubMed:20599547}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:17035250}. Note=co-localizes with ELN in elastic fibers. {ECO:0000269|PubMed:17035250}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":238,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000161202","exclusion_id":"X-ENSG00000161202","identifiers":{"approved_symbol":"DVL3","ensembl_gene_id":"ENSG00000161202"},"preferred_label":"DVL3","reconciliation":{"canonical_uniprot_accessions":["Q92997"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q92997","entry_name":"DVL3_HUMAN","gene_names":"DVL3 KIAA0208","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O14641}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":239,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000118777","identifiers":{"approved_symbol":"ABCG2","ensembl_gene_id":"ENSG00000118777"},"preferred_label":"ABCG2","reconciliation":{"canonical_uniprot_accessions":["Q9UNQ0"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000118777","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q9UNQ0","entry_name":"ABCG2_HUMAN","gene_names":"ABCG2 ABCP BCRP BCRP1 MXR","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15001581, ECO:0000269|PubMed:15769853, ECO:0000269|PubMed:15807535, ECO:0000269|PubMed:18056989, ECO:0000269|PubMed:31003562, ECO:0000269|PubMed:31254042}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:19506252}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000269|PubMed:23189181}; Multi-pass membrane protein {ECO:0000255}. Note=Enriched in membrane lipid rafts. {ECO:0000269|PubMed:28623970}.","topological_domain":"TOPO_DOM 1..395; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 417..428; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 450..477; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 499..506; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 528..535; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 557..630; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 652..655; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 396..416; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 429..449; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 478..498; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 507..527; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 536..556; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 631..651; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":240,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000259207","identifiers":{"approved_symbol":"ITGB3","ensembl_gene_id":"ENSG00000259207"},"preferred_label":"ITGB3","reconciliation":{"canonical_uniprot_accessions":["P05106"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000259207","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P05106","entry_name":"ITB3_HUMAN","gene_names":"ITGB3 GP3A","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..26; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20020534, ECO:0000269|PubMed:20702409, ECO:0000269|PubMed:9195946}; Single-pass type I membrane protein {ECO:0000269|PubMed:20020534, ECO:0000269|PubMed:20702409, ECO:0000269|PubMed:9195946}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:20702409}. Cell junction, focal adhesion {ECO:0000269|PubMed:20702409, ECO:0000269|PubMed:35687021}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:O54890}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O54890}. Synapse {ECO:0000250|UniProtKB:O54890}.","topological_domain":"TOPO_DOM 27..718; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 742..788; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 719..741; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":241,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000106366","exclusion_id":"X-ENSG00000106366","identifiers":{"approved_symbol":"SERPINE1","ensembl_gene_id":"ENSG00000106366"},"preferred_label":"SERPINE1","reconciliation":{"canonical_uniprot_accessions":["P05121"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P05121","entry_name":"PAI1_HUMAN","gene_names":"SERPINE1 PAI1 PLANH1","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"SIGNAL 1..23","subcellular_location":"SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2430793}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":242,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000096968","exclusion_id":"X-ENSG00000096968","identifiers":{"approved_symbol":"JAK2","ensembl_gene_id":"ENSG00000096968"},"preferred_label":"JAK2","reconciliation":{"canonical_uniprot_accessions":["O60674"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"O60674","entry_name":"JAK2_HUMAN","gene_names":"JAK2","lipidation":"","provisional_surface_signal":"membrane-only","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:19783980}. Nucleus {ECO:0000269|PubMed:19783980}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"membrane-only","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":243,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000085491","exclusion_id":"X-ENSG00000085491","identifiers":{"approved_symbol":"SLC25A24","ensembl_gene_id":"ENSG00000085491"},"preferred_label":"SLC25A24","reconciliation":{"canonical_uniprot_accessions":["Q6NUK1"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q6NUK1","entry_name":"SCMC1_HUMAN","gene_names":"SLC25A24 APC1 MCSC1 SCAMC1","lipidation":"","provisional_surface_signal":"membrane-only","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:15054102, ECO:0000305|PubMed:15123600, ECO:0000305|PubMed:22015608}; Multi-pass membrane protein {ECO:0000255}.","topological_domain":"TOPO_DOM 1..197; /note=\"Mitochondrial intermembrane\"; /evidence=\"ECO:0000305|PubMed:15054102\"; TOPO_DOM 216..252; /note=\"Mitochondrial matrix\"; /evidence=\"ECO:0000305|PubMed:15054102\"; TOPO_DOM 273..295; /note=\"Mitochondrial intermembrane\"; /evidence=\"ECO:0000305|PubMed:15054102\"; TOPO_DOM 310..345; /note=\"Mitochondrial matrix\"; /evidence=\"ECO:0000305|PubMed:15054102\"; TOPO_DOM 366..388; /note=\"Mitochondrial intermembrane\"; /evidence=\"ECO:0000305|PubMed:15054102\"; TOPO_DOM 407..445; /note=\"Mitochondrial matrix\"; /evidence=\"ECO:0000305|PubMed:15054102\"; TOPO_DOM 466..477; /note=\"Mitochondrial intermembrane\"; /evidence=\"ECO:0000305|PubMed:15054102\"","transmembrane":"TRANSMEM 198..215; /note=\"Helical; Name=1\"; /evidence=\"ECO:0000255\"; TRANSMEM 253..272; /note=\"Helical; Name=2\"; /evidence=\"ECO:0000255\"; TRANSMEM 296..309; /note=\"Helical; Name=3\"; /evidence=\"ECO:0000255\"; TRANSMEM 346..365; /note=\"Helical; Name=4\"; /evidence=\"ECO:0000255\"; TRANSMEM 389..406; /note=\"Helical; Name=5\"; /evidence=\"ECO:0000255\"; TRANSMEM 446..465; /note=\"Helical; Name=6\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"membrane-only","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":244,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000173546","identifiers":{"approved_symbol":"CSPG4","ensembl_gene_id":"ENSG00000173546"},"preferred_label":"CSPG4","reconciliation":{"canonical_uniprot_accessions":["Q6UVK1"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000173546","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q6UVK1","entry_name":"CSPG4_HUMAN","gene_names":"CSPG4 MCSP","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..29; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q00657}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q00657}; Extracellular side {ECO:0000250|UniProtKB:Q00657}. Apical cell membrane {ECO:0000250|UniProtKB:Q00657}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q00657}; Extracellular side {ECO:0000250|UniProtKB:Q00657}. Cell projection, lamellipodium membrane {ECO:0000250|UniProtKB:Q00657}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q00657}; Extracellular side {ECO:0000250|UniProtKB:Q00657}. Cell surface {ECO:0000250|UniProtKB:Q00657}. Note=Localized at the apical plasma membrane it relocalizes to the lamellipodia of astrocytoma upon phosphorylation by PRKCA. Localizes to the retraction fibers. Localizes to the plasma membrane of oligodendrocytes (By similarity). {ECO:0000250|UniProtKB:Q00657, ECO:0000250|UniProtKB:Q8VHY0}.","topological_domain":"TOPO_DOM 30..2224; /note=\"Extracellular\"; /evidence=\"ECO:0000250|UniProtKB:Q00657\"; TOPO_DOM 2246..2322; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000250|UniProtKB:Q00657\"","transmembrane":"TRANSMEM 2225..2245; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":245,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000169016","exclusion_id":"X-ENSG00000169016","identifiers":{"approved_symbol":"E2F6","ensembl_gene_id":"ENSG00000169016"},"preferred_label":"E2F6","reconciliation":{"canonical_uniprot_accessions":["O75461"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"O75461","entry_name":"E2F6_HUMAN","gene_names":"E2F6","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9689056, ECO:0000269|PubMed:9704927}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":246,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000107882","exclusion_id":"X-ENSG00000107882","identifiers":{"approved_symbol":"SUFU","ensembl_gene_id":"ENSG00000107882"},"preferred_label":"SUFU","reconciliation":{"canonical_uniprot_accessions":["Q9UMX1"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q9UMX1","entry_name":"SUFU_HUMAN","gene_names":"SUFU UNQ650/PRO1280","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10559945, ECO:0000269|PubMed:28965847}. Nucleus {ECO:0000269|PubMed:10559945, ECO:0000269|PubMed:28965847}. Cell projection, cilium {ECO:0000250|UniProtKB:Q9Z0P7}. 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Chromosome {ECO:0000269|PubMed:25574025, ECO:0000269|PubMed:25670504}. Note=Predominantly localizes to the nucleus. Accumulates at sites of DNA damage generated by laser microirradiation. {ECO:0000269|PubMed:25574025, ECO:0000269|PubMed:25670504}.; SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:29144403}. 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Cell membrane {ECO:0000250|UniProtKB:Q9ZUF4}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"plasma-membrane-annotation","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":257,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000164692","identifiers":{"approved_symbol":"COL1A2","ensembl_gene_id":"ENSG00000164692"},"preferred_label":"COL1A2","reconciliation":{"canonical_uniprot_accessions":["P08123"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"extracellular-matrix-retention-accessibility-unresolved","reasons":["Canonical reviewed UniProt explicitly reports extracellular-matrix localization, which is within the broad extracellular target scope.","Disease-site retention, extracellular accessibility, and cell of origin require review before retaining this as an actionable matrix target; it is not an intracellular or soluble-only exclusion."],"state":"unresolved","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"unresolved","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P08123","entry_name":"CO1A2_HUMAN","gene_names":"COL1A2","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"SIGNAL 1..22; /evidence=\"ECO:0000250|UniProtKB:P02466\"","subcellular_location":"SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000255|PROSITE-ProRule:PRU00793}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":258,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000162601","exclusion_id":"X-ENSG00000162601","identifiers":{"approved_symbol":"MYSM1","ensembl_gene_id":"ENSG00000162601"},"preferred_label":"MYSM1","reconciliation":{"canonical_uniprot_accessions":["Q5VVJ2"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q5VVJ2","entry_name":"MYSM1_HUMAN","gene_names":"MYSM1 KIAA1915","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:17707232}. Cytoplasm {ECO:0000250|UniProtKB:Q69Z66}. Note=Localizes to the cytoplasm in response to bacterial infection. {ECO:0000250|UniProtKB:Q69Z66}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":259,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000049449","exclusion_id":"X-ENSG00000049449","identifiers":{"approved_symbol":"RCN1","ensembl_gene_id":"ENSG00000049449"},"preferred_label":"RCN1","reconciliation":{"canonical_uniprot_accessions":["Q15293"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q15293","entry_name":"RCN1_HUMAN","gene_names":"RCN1 RCN","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"SIGNAL 1..29; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Endoplasmic reticulum lumen.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":260,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000118194","identifiers":{"approved_symbol":"TNNT2","ensembl_gene_id":"ENSG00000118194"},"preferred_label":"TNNT2","reconciliation":{"canonical_uniprot_accessions":["P45379"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"localization-unresolved","reasons":["The canonical reviewed UniProt entry has no decisive localization annotation."],"state":"unresolved","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"unresolved","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P45379","entry_name":"TNNT2_HUMAN","gene_names":"TNNT2","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":261,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000091542","exclusion_id":"X-ENSG00000091542","identifiers":{"approved_symbol":"ALKBH5","ensembl_gene_id":"ENSG00000091542"},"preferred_label":"ALKBH5","reconciliation":{"canonical_uniprot_accessions":["Q6P6C2"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q6P6C2","entry_name":"ALKB5_HUMAN","gene_names":"ALKBH5 ABH5 OFOXD1","lipidation":"","provisional_surface_signal":"membrane-only","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:21264265, ECO:0000269|PubMed:23177736, ECO:0000269|PubMed:37474102}. Nucleus, nucleoplasm {ECO:0000269|PubMed:40793791}. Note=Promotes formation and localizes to paraspeckles, a nuclear membraneless organelle. {ECO:0000269|PubMed:37474102}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"membrane-only","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":262,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000118217","exclusion_id":"X-ENSG00000118217","identifiers":{"approved_symbol":"ATF6","ensembl_gene_id":"ENSG00000118217"},"preferred_label":"ATF6","reconciliation":{"canonical_uniprot_accessions":["P18850"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P18850","entry_name":"ATF6A_HUMAN","gene_names":"ATF6","lipidation":"","provisional_surface_signal":"membrane-only","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10564271, ECO:0000269|PubMed:12782636}; Single-pass type II membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:12782636}; Single-pass type II membrane protein {ECO:0000255}. Note=Translocates from the endoplasmic reticulum to the Golgi, where it is processed. {ECO:0000269|PubMed:12782636}.; SUBCELLULAR LOCATION: [Processed cyclic AMP-dependent transcription factor ATF-6 alpha]: Nucleus {ECO:0000269|PubMed:10564271, ECO:0000269|PubMed:12782636}. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus (PubMed:10564271, PubMed:12782636). THBS4 promotes its nuclear shuttling (By similarity). {ECO:0000250|UniProtKB:F6VAN0, ECO:0000269|PubMed:10564271, ECO:0000269|PubMed:12782636}.","topological_domain":"TOPO_DOM 1..377; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 399..670; /note=\"Lumenal\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 378..398; /note=\"Helical; Signal-anchor for type II membrane protein\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"membrane-only","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":263,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000088836","identifiers":{"approved_symbol":"SLC4A11","ensembl_gene_id":"ENSG00000088836"},"preferred_label":"SLC4A11","reconciliation":{"canonical_uniprot_accessions":["Q8NBS3"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000088836","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q8NBS3","entry_name":"S4A11_HUMAN","gene_names":"SLC4A11 BTR1","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18024964, ECO:0000269|PubMed:25007886, ECO:0000269|PubMed:31273259}; Multi-pass membrane protein {ECO:0000255}. 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Note=Associates with chromatin. Highly associated with chromatin in G1/S and S phases, reduced binding to chromatin in G2, and further decreased binding in early M phase. It then reassociates with chromatin in late M phase. Dissociates from chromatin later than component of the MCM complex.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":265,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000168484","exclusion_id":"X-ENSG00000168484","identifiers":{"approved_symbol":"SFTPC","ensembl_gene_id":"ENSG00000168484"},"preferred_label":"SFTPC","reconciliation":{"canonical_uniprot_accessions":["P11686"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P11686","entry_name":"PSPC_HUMAN","gene_names":"SFTPC SFTP2","lipidation":"LIPID 28; /note=\"S-palmitoyl cysteine\"; /evidence=\"ECO:0000269|PubMed:2326260\"; LIPID 29; /note=\"S-palmitoyl cysteine\"; /evidence=\"ECO:0000269|PubMed:2326260\"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Secreted, extracellular space, surface film.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":266,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000171236","exclusion_id":"X-ENSG00000171236","identifiers":{"approved_symbol":"LRG1","ensembl_gene_id":"ENSG00000171236"},"preferred_label":"LRG1","reconciliation":{"canonical_uniprot_accessions":["P02750"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P02750","entry_name":"A2GL_HUMAN","gene_names":"LRG1 LRG","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"SIGNAL 1..35; /evidence=\"ECO:0000269|PubMed:3856868\"","subcellular_location":"SUBCELLULAR LOCATION: Secreted.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":267,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000135048","identifiers":{"approved_symbol":"CEMIP2","ensembl_gene_id":"ENSG00000135048"},"preferred_label":"CEMIP2","reconciliation":{"canonical_uniprot_accessions":["Q9UHN6"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000135048","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q9UHN6","entry_name":"CEIP2_HUMAN","gene_names":"CEMIP2 KIAA1412 TMEM2","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q5FWI3}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q5FWI3}.","topological_domain":"TOPO_DOM 1..82; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000250|UniProtKB:Q5FWI3\"; TOPO_DOM 104..1383; /note=\"Extracellular\"; /evidence=\"ECO:0000250|UniProtKB:Q5FWI3\"","transmembrane":"TRANSMEM 83..103; /note=\"Helical; Signal-anchor for type II membrane protein\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":268,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000132975","identifiers":{"approved_symbol":"GPR12","ensembl_gene_id":"ENSG00000132975"},"preferred_label":"GPR12","reconciliation":{"canonical_uniprot_accessions":["P47775"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000132975","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P47775","entry_name":"GPR12_HUMAN","gene_names":"GPR12","lipidation":"LIPID 317; /note=\"S-palmitoyl cysteine\"; /evidence=\"ECO:0000250\"","provisional_surface_signal":"extracellular-topology","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.","topological_domain":"TOPO_DOM 1..48; /note=\"Extracellular\"; /evidence=\"ECO:0000269|PubMed:36593162\"; TOPO_DOM 72..77; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:36593162\"; TOPO_DOM 104..113; /note=\"Extracellular\"; /evidence=\"ECO:0000269|PubMed:36593162\"; TOPO_DOM 137..153; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:36593162\"; TOPO_DOM 177..192; /note=\"Extracellular\"; /evidence=\"ECO:0000269|PubMed:36593162\"; TOPO_DOM 218..251; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:36593162\"; TOPO_DOM 275..280; /note=\"Extracellular\"; /evidence=\"ECO:0000269|PubMed:36593162\"; TOPO_DOM 304..334; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:36593162\"","transmembrane":"TRANSMEM 49..71; /note=\"Helical; Name=1\"; /evidence=\"ECO:0000269|PubMed:36593162\"; TRANSMEM 78..103; /note=\"Helical; Name=2\"; /evidence=\"ECO:0000269|PubMed:36593162\"; TRANSMEM 114..136; /note=\"Helical; Name=3\"; /evidence=\"ECO:0000269|PubMed:36593162\"; TRANSMEM 154..176; /note=\"Helical; Name=4\"; /evidence=\"ECO:0000269|PubMed:36593162\"; TRANSMEM 193..217; /note=\"Helical; Name=5\"; /evidence=\"ECO:0000269|PubMed:36593162\"; TRANSMEM 252..274; /note=\"Helical; Name=6\"; /evidence=\"ECO:0000269|PubMed:36593162\"; TRANSMEM 281..303; /note=\"Helical; Name=7\"; /evidence=\"ECO:0000269|PubMed:36593162\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":269,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000067141","identifiers":{"approved_symbol":"NEO1","ensembl_gene_id":"ENSG00000067141"},"preferred_label":"NEO1","reconciliation":{"canonical_uniprot_accessions":["Q92859"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000067141","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q92859","entry_name":"NEO1_HUMAN","gene_names":"NEO1 IGDCC2 NGN","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..33; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.","topological_domain":"TOPO_DOM 34..1105; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 1127..1461; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 1106..1126; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":270,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000187736","exclusion_id":"X-ENSG00000187736","identifiers":{"approved_symbol":"NHEJ1","ensembl_gene_id":"ENSG00000187736"},"preferred_label":"NHEJ1","reconciliation":{"canonical_uniprot_accessions":["Q9H9Q4"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q9H9Q4","entry_name":"NHEJ1_HUMAN","gene_names":"NHEJ1 XLF","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16439204, ECO:0000269|PubMed:16439205, ECO:0000269|PubMed:20558749}. Chromosome {ECO:0000269|PubMed:18064046, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:27437582}. Note=Localizes to site of double-strand breaks; recruitment is dependent on XRCC5-XRCC6 (Ku) heterodimer. {ECO:0000269|PubMed:18064046, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:27437582}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":271,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000126456","exclusion_id":"X-ENSG00000126456","identifiers":{"approved_symbol":"IRF3","ensembl_gene_id":"ENSG00000126456"},"preferred_label":"IRF3","reconciliation":{"canonical_uniprot_accessions":["Q14653"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q14653","entry_name":"IRF3_HUMAN","gene_names":"IRF3","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10805757, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:31340999, ECO:0000269|PubMed:31413131, ECO:0000269|PubMed:35922005, ECO:0000269|PubMed:36603579, ECO:0000269|PubMed:39761299, ECO:0000305|PubMed:25636800}. Nucleus {ECO:0000269|PubMed:10805757, ECO:0000269|PubMed:31340999, ECO:0000269|PubMed:31413131, ECO:0000269|PubMed:35922005, ECO:0000269|PubMed:36603579, ECO:0000269|PubMed:39761299, ECO:0000305|PubMed:25636800}. Mitochondrion {ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:39362857}. Note=Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect (PubMed:10805757, PubMed:35922005). When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm (PubMed:10805757). Recruited to mitochondria via TOMM70:HSP90AA1 upon Sendai virus infection (PubMed:25609812). {ECO:0000269|PubMed:10805757, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:35922005}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":272,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000164885","identifiers":{"approved_symbol":"CDK5","ensembl_gene_id":"ENSG00000164885"},"preferred_label":"CDK5","reconciliation":{"canonical_uniprot_accessions":["Q00535"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"conflicting-surface-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt localization places the canonical protein on the cytoplasmic face or as a peripheral membrane protein."],"state":"unresolved","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"unresolved","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q00535","entry_name":"CDK5_HUMAN","gene_names":"CDK5 CDKN5 PSSALRE","lipidation":"","provisional_surface_signal":"plasma-membrane-annotation","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:12691662}. Nucleus {ECO:0000269|PubMed:12691662}. Cell membrane {ECO:0000269|PubMed:17009320}; Peripheral membrane protein. Perikaryon. Cell projection, lamellipodium {ECO:0000250|UniProtKB:P49615}. Cell projection, growth cone {ECO:0000250|UniProtKB:P49615}. Postsynaptic density {ECO:0000250|UniProtKB:Q03114}. Synapse {ECO:0000250|UniProtKB:Q03114}. Note=In axonal growth cone with extension to the peripheral lamellipodia (By similarity). Under neurotoxic stress and neuronal injury conditions, CDK5R (p35) is cleaved by calpain to generate CDK5R1 (p25) in response to increased intracellular calcium. The elevated level of p25, when in complex with CDK5, leads to its subcellular misallocation as well as its hyperactivation. Colocalizes with CTNND2 in the cell body of neuronal cells, and with CTNNB1 in the cell-cell contacts and plasma membrane of undifferentiated and differentiated neuroblastoma cells. Reversibly attached to the plasma membrane in an inactive form when complexed to dephosphorylated p35 or CDK5R2 (p39), p35 phosphorylation releases this attachment and activates CDK5. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"plasma-membrane-annotation","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":273,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000134323","exclusion_id":"X-ENSG00000134323","identifiers":{"approved_symbol":"MYCN","ensembl_gene_id":"ENSG00000134323"},"preferred_label":"MYCN","reconciliation":{"canonical_uniprot_accessions":["P04198"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P04198","entry_name":"MYCN_HUMAN","gene_names":"MYCN BHLHE37 NMYC","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":274,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000108561","identifiers":{"approved_symbol":"C1QBP","ensembl_gene_id":"ENSG00000108561"},"preferred_label":"C1QBP","reconciliation":{"canonical_uniprot_accessions":["Q07021"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"conflicting-surface-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt localization places the canonical protein on the cytoplasmic face or as a peripheral membrane protein."],"state":"unresolved","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"unresolved","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q07021","entry_name":"C1QBP_HUMAN","gene_names":"C1QBP GC1QBP HABP1 SF2P32","lipidation":"","provisional_surface_signal":"plasma-membrane-annotation","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:15031724, ECO:0000269|PubMed:17486078, ECO:0000269|PubMed:19164550, ECO:0000269|PubMed:9305894}. Nucleus {ECO:0000269|PubMed:18676636, ECO:0000269|PubMed:9299613}. Nucleus, nucleolus {ECO:0000269|PubMed:21536856, ECO:0000269|PubMed:32958672}. Cell membrane {ECO:0000269|PubMed:10747014, ECO:0000269|PubMed:11493647, ECO:0000269|PubMed:12574814, ECO:0000269|PubMed:8195709, ECO:0000269|PubMed:8662673, ECO:0000269|PubMed:9191880, ECO:0000269|PubMed:9233640}; Peripheral membrane protein {ECO:0000269|PubMed:12574814, ECO:0000269|PubMed:8662673, ECO:0000269|PubMed:9191880}; Extracellular side. Secreted. Cytoplasm {ECO:0000269|PubMed:11493647, ECO:0000269|PubMed:9299613}. Note=Seems to be predominantly localized to mitochondria. Secreted by activated lymphocytes. Localizes to the nucleolus when coexpressed with POLGARF (PubMed:32958672). Interaction with POLGARF is likely to result in prevention of C1QBP maturation and redirection from mitochondria to nucleoli (PubMed:32958672). {ECO:0000269|PubMed:32958672}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"plasma-membrane-annotation","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":275,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000175063","identifiers":{"approved_symbol":"UBE2C","ensembl_gene_id":"ENSG00000175063"},"preferred_label":"UBE2C","reconciliation":{"canonical_uniprot_accessions":["O00762"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"localization-unresolved","reasons":["The canonical reviewed UniProt entry has no decisive localization annotation."],"state":"unresolved","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"unresolved","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"O00762","entry_name":"UBE2C_HUMAN","gene_names":"UBE2C UBCH10","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":276,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000165819","exclusion_id":"X-ENSG00000165819","identifiers":{"approved_symbol":"METTL3","ensembl_gene_id":"ENSG00000165819"},"preferred_label":"METTL3","reconciliation":{"canonical_uniprot_accessions":["Q86U44"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q86U44","entry_name":"MTA70_HUMAN","gene_names":"METTL3 MTA70","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:26458103, ECO:0000269|PubMed:27117702, ECO:0000269|PubMed:29348140, ECO:0000269|PubMed:29506078}. Nucleus speckle {ECO:0000269|PubMed:9409616}. Cytoplasm {ECO:0000269|PubMed:27117702}. Note=Colocalizes with speckles in interphase nuclei, suggesting that it may be associated with nuclear pre-mRNA splicing components (PubMed:9409616). In response to ultraviolet irradiation, colocalizes to DNA damage sites however, it probably does not bind DNA but localizes in the vicinity of DNA damage sites (PubMed:28297716). {ECO:0000269|PubMed:28297716, ECO:0000269|PubMed:9409616}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":277,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000111642","exclusion_id":"X-ENSG00000111642","identifiers":{"approved_symbol":"CHD4","ensembl_gene_id":"ENSG00000111642"},"preferred_label":"CHD4","reconciliation":{"canonical_uniprot_accessions":["Q14839"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q14839","entry_name":"CHD4_HUMAN","gene_names":"CHD4","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:27616479, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:33283408}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17626165}. Note=Associates with centrosomes in interphase (By similarity). Localizes to sites of DNA damage in a manner dependent on ZMYND8 and ZNF687 (PubMed:27732854, PubMed:28977666). {ECO:0000250|UniProtKB:Q6PDQ2, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:28977666}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":278,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000082781","identifiers":{"approved_symbol":"ITGB5","ensembl_gene_id":"ENSG00000082781"},"preferred_label":"ITGB5","reconciliation":{"canonical_uniprot_accessions":["P18084"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000082781","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P18084","entry_name":"ITB5_HUMAN","gene_names":"ITGB5","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..23; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.","topological_domain":"TOPO_DOM 24..719; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 743..799; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 720..742; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":279,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000130956","exclusion_id":"X-ENSG00000130956","identifiers":{"approved_symbol":"HABP4","ensembl_gene_id":"ENSG00000130956"},"preferred_label":"HABP4","reconciliation":{"canonical_uniprot_accessions":["Q5JVS0"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q5JVS0","entry_name":"HABP4_HUMAN","gene_names":"HABP4","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14699138, ECO:0000269|PubMed:16455055, ECO:0000269|PubMed:16879614, ECO:0000269|PubMed:19523114, ECO:0000269|PubMed:9523163}. Cytoplasm {ECO:0000269|PubMed:14699138, ECO:0000269|PubMed:16455055, ECO:0000269|PubMed:16879614, ECO:0000269|PubMed:19523114, ECO:0000269|PubMed:9523163}. Cytoplasm, Stress granule {ECO:0000269|PubMed:21771594}. Cytoplasm, sarcoplasm {ECO:0000250|UniProtKB:A1L1K8}. Nucleus, nuclear body {ECO:0000269|PubMed:19523114}. Nucleus, nucleolus {ECO:0000269|PubMed:19523114}. Nucleus speckle {ECO:0000269|PubMed:19523114}. Nucleus, Cajal body {ECO:0000269|PubMed:19523114}. Nucleus, gem {ECO:0000269|PubMed:19523114}. Note=Transported into the nuclear compartment in activated leukocytes (PubMed:9523163). Inhibition of methylation alters its distribution between the nuclear and cytoplasmic compartments (PubMed:16879614, PubMed:19523114). Methylation may be required for its localization in subnuclear structures, such as nucleoli, nuclear speckles, Cajal bodies and Gemini of coiled bodies (gems) (PubMed:19523114). Colocalizes with FMR1, FXR1 and FXR2 in cytoplasmic stress granules (PubMed:21771594). In myocardial cells, localization at the sarcoplasm is reduced in response to mechanical stress (By similarity). {ECO:0000250|UniProtKB:A1L1K8, ECO:0000269|PubMed:16879614, ECO:0000269|PubMed:19523114, ECO:0000269|PubMed:21771594, ECO:0000269|PubMed:9523163}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":280,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000102854","identifiers":{"approved_symbol":"MSLN","ensembl_gene_id":"ENSG00000102854"},"preferred_label":"MSLN","query_expansion_seeds":[{"category":"context-dependent","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["Q13421"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt records an integral or GPI-anchored membrane form."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000102854","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q13421","entry_name":"MSLN_HUMAN","gene_names":"MSLN MPF","lipidation":"LIPID 598; /note=\"GPI-anchor amidated serine\"; /evidence=\"ECO:0000255\"","provisional_surface_signal":"plasma-membrane-annotation","signal_peptide":"SIGNAL 1..36; /evidence=\"ECO:0000269|PubMed:7665620\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus.; SUBCELLULAR LOCATION: [Megakaryocyte-potentiating factor]: Secreted.; SUBCELLULAR LOCATION: [Isoform 5]: Secreted.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"plasma-membrane-annotation","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":281,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000117707","exclusion_id":"X-ENSG00000117707","identifiers":{"approved_symbol":"PROX1","ensembl_gene_id":"ENSG00000117707"},"preferred_label":"PROX1","reconciliation":{"canonical_uniprot_accessions":["Q92786"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q92786","entry_name":"PROX1_HUMAN","gene_names":"PROX1","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P48437}. Note=RORG promotes its nuclear localization. {ECO:0000250|UniProtKB:P48437}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":282,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000120129","exclusion_id":"X-ENSG00000120129","identifiers":{"approved_symbol":"DUSP1","ensembl_gene_id":"ENSG00000120129"},"preferred_label":"DUSP1","reconciliation":{"canonical_uniprot_accessions":["P28562"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P28562","entry_name":"DUS1_HUMAN","gene_names":"DUSP1 CL100 MKP1 PTPN10 VH1","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q91790}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":283,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000182979","exclusion_id":"X-ENSG00000182979","identifiers":{"approved_symbol":"MTA1","ensembl_gene_id":"ENSG00000182979"},"preferred_label":"MTA1","reconciliation":{"canonical_uniprot_accessions":["Q13330"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q13330","entry_name":"MTA1_HUMAN","gene_names":"MTA1","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:33283408}.; SUBCELLULAR LOCATION: [Isoform Short]: Cytoplasm {ECO:0000269|PubMed:12167865, ECO:0000269|PubMed:15077195}.; SUBCELLULAR LOCATION: [Isoform Long]: Nucleus {ECO:0000269|PubMed:21965678}. Nucleus envelope {ECO:0000269|PubMed:24970816}. Cytoplasm {ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:24970816}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:24970816}. Note=Associated with microtubules (PubMed:24970816). Localization at the nuclear envelope is TPR-dependent (PubMed:24970816). {ECO:0000269|PubMed:24970816}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":284,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000187555","exclusion_id":"X-ENSG00000187555","identifiers":{"approved_symbol":"USP7","ensembl_gene_id":"ENSG00000187555"},"preferred_label":"USP7","reconciliation":{"canonical_uniprot_accessions":["Q93009"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q93009","entry_name":"UBP7_HUMAN","gene_names":"USP7 HAUSP","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21258371, ECO:0000269|PubMed:23973222, ECO:0000269|PubMed:25283148, ECO:0000269|PubMed:26678539}. Cytoplasm {ECO:0000269|PubMed:25283148}. Nucleus, PML body {ECO:0000269|PubMed:9034339}. Chromosome {ECO:0000269|PubMed:20601937}. Note=Present in a minority of ND10 nuclear bodies (PubMed:9034339). Association with ICP0/VMW110 at early times of infection leads to an increased proportion of USP7-containing ND10 (PubMed:9034339). Colocalizes with ATXN1 in the nucleus (PubMed:12093161). Colocalized with DAXX in speckled structures (PubMed:16845383). Colocalized with PML and PTEN in promyelocytic leukemia protein (PML) nuclear bodies (PubMed:18716620). Interaction with FAM170A promotes its nuclear translocation (By similarity). {ECO:0000250|UniProtKB:Q6A4J8, ECO:0000269|PubMed:12093161, ECO:0000269|PubMed:16845383, ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:9034339}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":285,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000066405","identifiers":{"approved_symbol":"CLDN18","ensembl_gene_id":"ENSG00000066405"},"preferred_label":"CLDN18","query_expansion_seeds":[{"category":"context-dependent","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["P56856"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000066405","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P56856","entry_name":"CLD18_HUMAN","gene_names":"CLDN18 UNQ778/PRO1572","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000250|UniProtKB:P56857}. Cell membrane {ECO:0000250|UniProtKB:P56857}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to tight junctions in epithelial cells. {ECO:0000250|UniProtKB:P56857}.; SUBCELLULAR LOCATION: [Isoform A1]: Cell junction, tight junction {ECO:0000250|UniProtKB:P56857}.; SUBCELLULAR LOCATION: [Isoform A2]: Cell junction, tight junction {ECO:0000250|UniProtKB:P56857}. Lateral cell membrane {ECO:0000250|UniProtKB:P56857}.","topological_domain":"TOPO_DOM 1..6; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 28..80; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 102..122; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 144..174; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 196..261; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 7..27; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 81..101; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 123..143; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 175..195; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":286,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous 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Chromosome, centromere, kinetochore {ECO:0000269|PubMed:14978040, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:22351768, ECO:0000269|PubMed:29162720}. Nucleus envelope {ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:22351768}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14978040, ECO:0000269|PubMed:9546394}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:9546394}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:22351768}. Note=Co-localizes with TPR at the nucleus envelope during interphase and throughout the cell cycle (PubMed:18981471, PubMed:22351768). From the beginning to the end of mitosis, it is seen to move from a diffusely nuclear distribution to the centrosome, to the spindle midzone and finally to the midbody (PubMed:9546394). Localizes to kinetochores during prometaphase (PubMed:22351768, PubMed:29162720). Does not localize to kinetochores during metaphase (PubMed:29162720). Colocalizes with NEK2 at the kinetochore (PubMed:14978040). Colocalizes with IK at spindle poles during metaphase and anaphase (PubMed:22351768). {ECO:0000269|PubMed:14978040, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:22351768, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:9546394}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:19010891}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":290,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000139515","exclusion_id":"X-ENSG00000139515","identifiers":{"approved_symbol":"PDX1","ensembl_gene_id":"ENSG00000139515"},"preferred_label":"PDX1","reconciliation":{"canonical_uniprot_accessions":["P52945"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"O00330","entry_name":"ODPX_HUMAN","gene_names":"PDHX PDX1","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Mitochondrion matrix.","topological_domain":"","transmembrane":""},{"accession":"P52945","entry_name":"PDX1_HUMAN","gene_names":"PDX1 IPF1 STF1","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus. 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Single-pass type II membrane protein {ECO:0000250}.","topological_domain":"TOPO_DOM 1..6; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 27..438; /note=\"Lumenal\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 7..26; /note=\"Helical; Signal-anchor for type II membrane protein\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"membrane-only","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":293,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000026508","identifiers":{"approved_symbol":"CD44","ensembl_gene_id":"ENSG00000026508"},"preferred_label":"CD44","reconciliation":{"canonical_uniprot_accessions":["P16070"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000026508","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P16070","entry_name":"CD44_HUMAN","gene_names":"CD44 LHR MDU2 MDU3 MIC4","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..20; 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Cell projection, microvillus {ECO:0000250|UniProtKB:P15379}. Secreted {ECO:0000269|PubMed:25326458, ECO:0000269|PubMed:36213313, ECO:0000269|PubMed:37453717}. Note=Colocalizes with actin in membrane protrusions at wounding edges. Co-localizes with RDX, EZR and MSN in microvilli. Localizes to cholesterol-rich membrane-bound lipid raft domains. {ECO:0000250|UniProtKB:P15379, ECO:0000269|PubMed:23589287}.","topological_domain":"TOPO_DOM 21..649; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 671..742; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 650..670; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":294,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000135220","exclusion_id":"X-ENSG00000135220","identifiers":{"approved_symbol":"UGT2A3","ensembl_gene_id":"ENSG00000135220"},"preferred_label":"UGT2A3","reconciliation":{"canonical_uniprot_accessions":["Q6UWM9"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q6UWM9","entry_name":"UD2A3_HUMAN","gene_names":"UGT2A3 UNQ2559/PRO6239","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..23; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.","topological_domain":"TOPO_DOM 24..491; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 513..527; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 492..512; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":295,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000127585","identifiers":{"approved_symbol":"FBXL16","ensembl_gene_id":"ENSG00000127585"},"preferred_label":"FBXL16","reconciliation":{"canonical_uniprot_accessions":["Q8N461"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"localization-unresolved","reasons":["The canonical reviewed UniProt entry has no decisive localization annotation."],"state":"unresolved","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"unresolved","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q8N461","entry_name":"FXL16_HUMAN","gene_names":"FBXL16 C16orf22 FBL16","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":296,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000198561","identifiers":{"approved_symbol":"CTNND1","ensembl_gene_id":"ENSG00000198561"},"preferred_label":"CTNND1","reconciliation":{"canonical_uniprot_accessions":["O60716"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000198561","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"O60716","entry_name":"CTND1_HUMAN","gene_names":"CTNND1 KIAA0384","lipidation":"","provisional_surface_signal":"plasma-membrane-annotation","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000269|PubMed:11896187}. Cytoplasm {ECO:0000269|PubMed:15240885, ECO:0000269|PubMed:17047063}. Nucleus {ECO:0000269|PubMed:11896187, ECO:0000269|PubMed:17115030}. Cell membrane {ECO:0000269|PubMed:15240885, ECO:0000269|PubMed:17047063}. Cell junction {ECO:0000269|PubMed:18343367}. Note=Interaction with GLIS2 promotes nuclear translocation (By similarity). Detected at cell-cell contacts (PubMed:15240885, PubMed:17047063). NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm (PubMed:17047063). CDH1 enhances cell membrane localization (PubMed:15240885). Localizes to cell-cell contacts as keratinocyte differentiation progresses (By similarity). {ECO:0000250|UniProtKB:P30999, ECO:0000269|PubMed:11896187, ECO:0000269|PubMed:15240885, ECO:0000269|PubMed:17047063}.; SUBCELLULAR LOCATION: [Isoform 1A]: Nucleus {ECO:0000269|PubMed:11896187}.; SUBCELLULAR LOCATION: [Isoform 2A]: Nucleus {ECO:0000269|PubMed:11896187}.; SUBCELLULAR LOCATION: [Isoform 3A]: Nucleus {ECO:0000269|PubMed:11896187}.; SUBCELLULAR LOCATION: [Isoform 4A]: Cytoplasm {ECO:0000269|PubMed:11896187}.; SUBCELLULAR LOCATION: [Isoform 1AB]: Cytoplasm {ECO:0000269|PubMed:11896187}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"plasma-membrane-annotation","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":297,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000100030","exclusion_id":"X-ENSG00000100030","identifiers":{"approved_symbol":"MAPK1","ensembl_gene_id":"ENSG00000100030"},"preferred_label":"MAPK1","reconciliation":{"canonical_uniprot_accessions":["P28482"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P28482","entry_name":"MK01_HUMAN","gene_names":"MAPK1 ERK2 PRKM1 PRKM2","lipidation":"","provisional_surface_signal":"membrane-only","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Nucleus {ECO:0000269|PubMed:32721402}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm {ECO:0000269|PubMed:32721402}. Membrane, caveola {ECO:0000250|UniProtKB:P63086}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:P63085}. Note=Associated with the spindle during prometaphase and metaphase (By similarity). PEA15-binding and phosphorylated DAPK1 promote its cytoplasmic retention. Phosphorylation at Ser- 246 and Ser-248 as well as autophosphorylation at Thr-190 promote nuclear localization. {ECO:0000250}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"membrane-only","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":298,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000104852","exclusion_id":"X-ENSG00000104852","identifiers":{"approved_symbol":"SNRNP70","ensembl_gene_id":"ENSG00000104852"},"preferred_label":"SNRNP70","reconciliation":{"canonical_uniprot_accessions":["P08621"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P08621","entry_name":"RU17_HUMAN","gene_names":"SNRNP70 RNPU1Z RPU1 SNRP70 U1AP1","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:17656373}. Nucleus, nucleoplasm {ECO:0000269|PubMed:17656373, ECO:0000269|PubMed:21113136}. Note=Colocalizes with SCNM1 and LUC7L2 in nuclear speckles. {ECO:0000250|UniProtKB:Q62376}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":299,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000074181","identifiers":{"approved_symbol":"NOTCH3","ensembl_gene_id":"ENSG00000074181"},"preferred_label":"NOTCH3","query_expansion_seeds":[{"category":"stroma-and-vasculature","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["Q9UM47"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000074181","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q9UM47","entry_name":"NOTC3_HUMAN","gene_names":"NOTCH3","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..39; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15350543}; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Notch 3 intracellular domain]: Nucleus. Note=Following proteolytical processing NICD is translocated to the nucleus.","topological_domain":"TOPO_DOM 40..1643; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 1665..2321; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 1644..1664; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":300,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000143641","exclusion_id":"X-ENSG00000143641","identifiers":{"approved_symbol":"GALNT2","ensembl_gene_id":"ENSG00000143641"},"preferred_label":"GALNT2","reconciliation":{"canonical_uniprot_accessions":["Q10471"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q10471","entry_name":"GALT2_HUMAN","gene_names":"GALNT2","lipidation":"","provisional_surface_signal":"membrane-only","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:9394011}; Single-pass type II membrane protein {ECO:0000269|PubMed:9394011}. Secreted {ECO:0000269|PubMed:37453717, ECO:0000269|PubMed:9394011}. Note=Resides preferentially in the trans and medial parts of the Golgi stack. A secreted form also exists.","topological_domain":"TOPO_DOM 1..6; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 25..571; /note=\"Lumenal\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 7..24; /note=\"Helical; Signal-anchor for type II membrane protein\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"membrane-only","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":301,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000115419","exclusion_id":"X-ENSG00000115419","identifiers":{"approved_symbol":"GLS","ensembl_gene_id":"ENSG00000115419"},"preferred_label":"GLS","reconciliation":{"canonical_uniprot_accessions":["O94925"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"O94925","entry_name":"GLSK_HUMAN","gene_names":"GLS GLS1 KIAA0838","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion {ECO:0000250|UniProtKB:P13264}. Cytoplasm, cytosol {ECO:0000269|PubMed:22228304}. Note=The 74-kDa cytosolic precursor is translocated into the mitochondria and processed via a 72-kDa intermediate to yield the mature 68- and 65-kDa subunits. {ECO:0000250|UniProtKB:P13264}.; SUBCELLULAR LOCATION: [Isoform 3]: Mitochondrion {ECO:0000269|PubMed:22228304}.; SUBCELLULAR LOCATION: [Glutaminase kidney isoform, mitochondrial 68 kDa chain]: Mitochondrion matrix {ECO:0000250|UniProtKB:P13264}. Note=Produced by the proteolytic processing of the 74-kDa cytosolic precursor. {ECO:0000250|UniProtKB:P13264}.; SUBCELLULAR LOCATION: [Glutaminase kidney isoform, mitochondrial 65 kDa chain]: Mitochondrion matrix {ECO:0000250|UniProtKB:P13264}. Note=Produced by the proteolytic processing of the 74-kDa cytosolic precursor. {ECO:0000250|UniProtKB:P13264}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":302,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000197635","identifiers":{"approved_symbol":"DPP4","ensembl_gene_id":"ENSG00000197635"},"preferred_label":"DPP4","reconciliation":{"canonical_uniprot_accessions":["P27487"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000197635","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P27487","entry_name":"DPP4_HUMAN","gene_names":"DPP4 ADCP2 CD26","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: [Dipeptidyl peptidase 4 soluble form]: Secreted {ECO:0000269|PubMed:10951221, ECO:0000269|PubMed:16254193}. Note=Detected in the serum and the seminal fluid. {ECO:0000269|PubMed:10951221, ECO:0000269|PubMed:16254193}.; SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10900005, ECO:0000269|PubMed:11772392, ECO:0000305|PubMed:8101391}; Single-pass type II membrane protein. Apical cell membrane {ECO:0000269|PubMed:11773049}; Single-pass type II membrane protein. Cell projection, invadopodium membrane {ECO:0000269|PubMed:16651416}; Single-pass type II membrane protein. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:16651416}; Single-pass type II membrane protein. Cell junction {ECO:0000269|PubMed:11772392}. Membrane raft {ECO:0000269|PubMed:17287217}. Note=Translocated to the apical membrane through the concerted action of N- and O-Glycans and its association with lipid microdomains containing cholesterol and sphingolipids (PubMed:11773049). Redistributed to membrane rafts in T-cell in an interleukin-12-dependent activation (PubMed:12676959). Its interaction with CAV1 is necessary for its translocation to membrane rafts (PubMed:17287217). Colocalized with PTPRC in membrane rafts (PubMed:12676959). Colocalized with FAP in invadopodia and lamellipodia of migratory activated endothelial cells in collagenous matrix. Colocalized with FAP on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma (PubMed:16651416). Colocalized with ADA at the cell junction in lymphocyte-epithelial cell adhesion (PubMed:11772392). Colocalized with IGF2R in internalized cytoplasmic vesicles adjacent to the cell surface (PubMed:10900005). {ECO:0000269|PubMed:10900005, ECO:0000269|PubMed:11772392, ECO:0000269|PubMed:11773049, ECO:0000269|PubMed:12676959, ECO:0000269|PubMed:16651416, ECO:0000269|PubMed:17287217}.","topological_domain":"TOPO_DOM 1..6; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 29..766; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 7..28; /note=\"Helical; Signal-anchor for type II membrane protein\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":303,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000132698","identifiers":{"approved_symbol":"RAB25","ensembl_gene_id":"ENSG00000132698"},"preferred_label":"RAB25","reconciliation":{"canonical_uniprot_accessions":["P57735"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"conflicting-surface-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt localization places the canonical protein on the cytoplasmic face or as a peripheral membrane protein."],"state":"unresolved","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"unresolved","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P57735","entry_name":"RAB25_HUMAN","gene_names":"RAB25 CATX8","lipidation":"LIPID 209; /note=\"S-geranylgeranyl cysteine\"; /evidence=\"ECO:0000250\"; LIPID 210; /note=\"S-geranylgeranyl cysteine\"; /evidence=\"ECO:0000250\"","provisional_surface_signal":"plasma-membrane-annotation","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle {ECO:0000269|PubMed:17925226}. Cell projection, pseudopodium membrane {ECO:0000269|PubMed:17925226}. Note=Colocalizes with integrin alpha-V/beta-1 in vesicles at the pseudopodial tips. Colocalizes with RAB11A in subapical vesicles (By similarity). {ECO:0000250|UniProtKB:P46629, ECO:0000269|PubMed:17925226}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"plasma-membrane-annotation","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":304,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000118972","exclusion_id":"X-ENSG00000118972","identifiers":{"approved_symbol":"FGF23","ensembl_gene_id":"ENSG00000118972"},"preferred_label":"FGF23","reconciliation":{"canonical_uniprot_accessions":["Q9GZV9"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q9GZV9","entry_name":"FGF23_HUMAN","gene_names":"FGF23 HYPF UNQ3027/PRO9828","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"SIGNAL 1..24; /evidence=\"ECO:0000269|PubMed:15340161\"","subcellular_location":"SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16638743}. Note=Secretion is dependent on O-glycosylation.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":305,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000146731","exclusion_id":"X-ENSG00000146731","identifiers":{"approved_symbol":"CCT6A","ensembl_gene_id":"ENSG00000146731"},"preferred_label":"CCT6A","reconciliation":{"canonical_uniprot_accessions":["P40227"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P40227","entry_name":"TCPZ_HUMAN","gene_names":"CCT6A CCT6 CCTZ","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:8034610}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":306,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000172270","identifiers":{"approved_symbol":"BSG","ensembl_gene_id":"ENSG00000172270"},"preferred_label":"BSG","reconciliation":{"canonical_uniprot_accessions":["P35613"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000172270","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P35613","entry_name":"BASI_HUMAN","gene_names":"BSG UNQ6505/PRO21383","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..21; /evidence=\"ECO:0000269|PubMed:15340161\"","subcellular_location":"SUBCELLULAR LOCATION: Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:17081065}.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:25957687}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453}. Photoreceptor inner segment {ECO:0000250|UniProtKB:P18572}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:P18572}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:11992541, ECO:0000269|PubMed:15688292, ECO:0000269|PubMed:15946952, ECO:0000269|PubMed:17127621, ECO:0000269|PubMed:21536654, ECO:0000269|PubMed:25825981, ECO:0000269|PubMed:26195724, ECO:0000269|PubMed:28409866, ECO:0000269|PubMed:29739904}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453}. Endosome {ECO:0000269|PubMed:29739904}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:15688292}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453}. Basolateral cell membrane {ECO:0000269|PubMed:17267690}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453}.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane {ECO:0000269|PubMed:21536654}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453}.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane {ECO:0000269|PubMed:21536654}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453}.","topological_domain":"TOPO_DOM 138..325; /note=\"Extracellular\"; /evidence=\"ECO:0000269|PubMed:34625749, ECO:0000269|PubMed:38364890, ECO:0007744|PDB:7DCE, ECO:0007744|PDB:8XEJ\"; TOPO_DOM 345..385; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:34625749, ECO:0000269|PubMed:38364890, ECO:0007744|PDB:7DCE, ECO:0007744|PDB:8XEJ\"","transmembrane":"TRANSMEM 326..344; /note=\"Helical\"; /evidence=\"ECO:0000269|PubMed:34625749, ECO:0000269|PubMed:38364890, ECO:0007744|PDB:7DCE, ECO:0007744|PDB:8XEJ\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":307,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000124216","exclusion_id":"X-ENSG00000124216","identifiers":{"approved_symbol":"SNAI1","ensembl_gene_id":"ENSG00000124216"},"preferred_label":"SNAI1","reconciliation":{"canonical_uniprot_accessions":["O95863"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"O95863","entry_name":"SNAI1_HUMAN","gene_names":"SNAI1 SNAH","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15448698, ECO:0000269|PubMed:15833848, ECO:0000269|PubMed:20389281, ECO:0000269|PubMed:24157836, ECO:0000269|PubMed:24699649, ECO:0000269|PubMed:25827072, ECO:0000269|PubMed:25893292}. Cytoplasm {ECO:0000269|PubMed:15448698, ECO:0000269|PubMed:15833848}. Note=Once phosphorylated (probably on Ser-107, Ser-111, Ser-115 and Ser-119) it is exported from the nucleus to the cytoplasm where subsequent phosphorylation of the destruction motif and ubiquitination involving BTRC occurs. {ECO:0000269|PubMed:15448698}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":308,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000164934","exclusion_id":"X-ENSG00000164934","identifiers":{"approved_symbol":"DCAF13","ensembl_gene_id":"ENSG00000164934"},"preferred_label":"DCAF13","reconciliation":{"canonical_uniprot_accessions":["Q9NV06"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q9NV06","entry_name":"DCA13_HUMAN","gene_names":"DCAF13 WDSOF1 HSPC064","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:24754225, ECO:0000269|PubMed:30283081, ECO:0000269|PubMed:34516797}. 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Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Rapidly and constitutively internalized to the trans-Golgi network at steady state. Internalization to the trans-Golgi network may be the result of phosphorylation at Ser-861 and Ser-864; however, the phosphorylation event has not been proven (PubMed:23439653). {ECO:0000269|PubMed:23439653}.","topological_domain":"TOPO_DOM 22..561; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 583..593; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 615..638; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 660..682; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 704..722; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 744..767; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 789..802; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 824..907; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 562..582; /note=\"Helical; Name=1\"; /evidence=\"ECO:0000255\"; TRANSMEM 594..614; /note=\"Helical; Name=2\"; /evidence=\"ECO:0000255\"; TRANSMEM 639..659; /note=\"Helical; Name=3\"; /evidence=\"ECO:0000255\"; TRANSMEM 683..703; /note=\"Helical; Name=4\"; /evidence=\"ECO:0000255\"; TRANSMEM 723..743; /note=\"Helical; Name=5\"; /evidence=\"ECO:0000255\"; TRANSMEM 768..788; /note=\"Helical; Name=6\"; /evidence=\"ECO:0000255\"; TRANSMEM 803..823; /note=\"Helical; Name=7\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":327,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000137809","identifiers":{"approved_symbol":"ITGA11","ensembl_gene_id":"ENSG00000137809"},"preferred_label":"ITGA11","reconciliation":{"canonical_uniprot_accessions":["Q9UKX5"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000137809","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q9UKX5","entry_name":"ITA11_HUMAN","gene_names":"ITGA11 MSTP018","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..22; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.","topological_domain":"TOPO_DOM 23..1141; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 1165..1188; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 1142..1164; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":328,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000165140","identifiers":{"approved_symbol":"FBP1","ensembl_gene_id":"ENSG00000165140"},"preferred_label":"FBP1","reconciliation":{"canonical_uniprot_accessions":["P09467"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"localization-unresolved","reasons":["The canonical reviewed UniProt entry has no decisive localization annotation."],"state":"unresolved","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"unresolved","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P09467","entry_name":"F16P1_HUMAN","gene_names":"FBP1 FBP","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":329,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000130300","identifiers":{"approved_symbol":"PLVAP","ensembl_gene_id":"ENSG00000130300"},"preferred_label":"PLVAP","query_expansion_seeds":[{"category":"stroma-and-vasculature","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["Q9BX97"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000130300","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q9BX97","entry_name":"PLVAP_HUMAN","gene_names":"PLVAP FELS PV1","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9WV78}; Single-pass type II membrane protein {ECO:0000255}. Membrane, caveola {ECO:0000250|UniProtKB:Q9WV78}; Single-pass type II membrane protein {ECO:0000255}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9WV78}. Note=Membrane-associated protein of caveolae. Found in fenestral and stomatal diaphragms in fenestrated endothelia and transendothelial channels. Also colocalized with CAV1 in perinuclear region. {ECO:0000250|UniProtKB:Q9WV78}.","topological_domain":"TOPO_DOM 1..27; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 49..442; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 28..48; /note=\"Helical; Signal-anchor for type II membrane protein\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":330,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000050165","exclusion_id":"X-ENSG00000050165","identifiers":{"approved_symbol":"DKK3","ensembl_gene_id":"ENSG00000050165"},"preferred_label":"DKK3","reconciliation":{"canonical_uniprot_accessions":["Q9UBP4"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q9UBP4","entry_name":"DKK3_HUMAN","gene_names":"DKK3 REIC UNQ258/PRO295","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"SIGNAL 1..21; /evidence=\"ECO:0000269|PubMed:15340161, ECO:0000269|PubMed:19838169\"","subcellular_location":"SUBCELLULAR LOCATION: Secreted.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":331,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000139266","exclusion_id":"X-ENSG00000139266","identifiers":{"approved_symbol":"MARCHF9","ensembl_gene_id":"ENSG00000139266"},"preferred_label":"MARCHF9","reconciliation":{"canonical_uniprot_accessions":["Q86YJ5"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q86YJ5","entry_name":"MARH9_HUMAN","gene_names":"MARCHF9 MARCH9 RNF179","lipidation":"","provisional_surface_signal":"membrane-only","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:14722266}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:17174307}; Multi-pass membrane protein {ECO:0000255}.","topological_domain":"","transmembrane":"TRANSMEM 185..205; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 219..239; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"membrane-only","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":332,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000011426","exclusion_id":"X-ENSG00000011426","identifiers":{"approved_symbol":"ANLN","ensembl_gene_id":"ENSG00000011426"},"preferred_label":"ANLN","reconciliation":{"canonical_uniprot_accessions":["Q9NQW6"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q9NQW6","entry_name":"ANLN_HUMAN","gene_names":"ANLN","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex {ECO:0000269|PubMed:23870127}. Cell projection, bleb {ECO:0000269|PubMed:23870127}. Note=Mainly found in the nucleus during interphase. Colocalizes with cortical F-actin upon nuclear envelope breakdown in mitosis and subsequently concentrates in the area of the prospective contractile ring in anaphase. This pattern persists until telophase, when the protein becomes concentrated in the midbody.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":333,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000153187","identifiers":{"approved_symbol":"HNRNPU","ensembl_gene_id":"ENSG00000153187"},"preferred_label":"HNRNPU","reconciliation":{"canonical_uniprot_accessions":["Q00839"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"extracellular-accessibility-unresolved","reasons":["A membrane or cell-surface localization is reported, but extracellular orientation or anchoring is unresolved."],"state":"unresolved","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"unresolved","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q00839","entry_name":"HNRPU_HUMAN","gene_names":"HNRNPU C1orf199 HNRPU SAFA U21.1","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10671544, ECO:0000269|PubMed:11003645, ECO:0000269|PubMed:1324173, ECO:0000269|PubMed:14608463, ECO:0000269|PubMed:15563465, ECO:0000269|PubMed:19617346, ECO:0000269|PubMed:21242313, ECO:0000269|PubMed:8174554, ECO:0000269|PubMed:9353307, ECO:0000269|PubMed:9405365}. Nucleus matrix {ECO:0000269|PubMed:1324173, ECO:0000269|PubMed:14608463, ECO:0000269|PubMed:8174554}. Chromosome {ECO:0000269|PubMed:11003645, ECO:0000269|PubMed:14608463, ECO:0000269|PubMed:15563465}. Nucleus speckle {ECO:0000269|PubMed:9353307}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:25986610}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:21242313}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:21242313, ECO:0000269|PubMed:25986610}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:21242313}. Midbody {ECO:0000269|PubMed:25986610}. Cytoplasm {ECO:0000269|PubMed:19029303}. Cell surface {ECO:0000269|PubMed:7993898}. Cytoplasmic granule {ECO:0000269|PubMed:17289661}. Note=Localizes at inactive X chromosome (Xi) regions (PubMed:11003645, PubMed:14608463, PubMed:15563465). Localizes in the nucleus during interphase (PubMed:21242313). At metaphase, localizes with mitotic spindle microtubules (MTs) (PubMed:21242313). At anaphase, localizes in the mitotic spindle midzone (PubMed:21242313). Localizes in spindle MTs proximal to spindle poles in a TPX2- and AURKA-dependent manner (PubMed:21242313). The Ser-59 phosphorylated form localizes to centrosomes during prophase and metaphase, to mitotic spindles in anaphase and to the midbody during cytokinesis (PubMed:25986610). Colocalizes with SMARCA4 in the nucleus (By similarity). Colocalizes with CBX5 in the nucleus (PubMed:19617346). Colocalizes with NR3C1 in nuclear speckles (PubMed:9353307). Localized in cytoplasmic ribonucleoprotein (RNP) granules containing untranslated mRNAs (PubMed:17289661). {ECO:0000250|UniProtKB:Q8VEK3, ECO:0000269|PubMed:11003645, ECO:0000269|PubMed:14608463, ECO:0000269|PubMed:15563465, ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:19617346, ECO:0000269|PubMed:21242313, ECO:0000269|PubMed:25986610, ECO:0000269|PubMed:9353307}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":334,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000196092","exclusion_id":"X-ENSG00000196092","identifiers":{"approved_symbol":"PAX5","ensembl_gene_id":"ENSG00000196092"},"preferred_label":"PAX5","reconciliation":{"canonical_uniprot_accessions":["Q02548"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q02548","entry_name":"PAX5_HUMAN","gene_names":"PAX5","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31941781}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":335,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000169047","identifiers":{"approved_symbol":"IRS1","ensembl_gene_id":"ENSG00000169047"},"preferred_label":"IRS1","reconciliation":{"canonical_uniprot_accessions":["P35568"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000169047","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P35568","entry_name":"IRS1_HUMAN","gene_names":"IRS1","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19639489}. Nucleus {ECO:0000269|PubMed:19639489}. Note=Nuclear or cytoplasmic localization of IRS1 correlates with the transition from proliferation to chondrogenic differentiation. {ECO:0000269|PubMed:19639489}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":336,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets 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During bacterial infection, displays a collar shape structure next to actin at the pole of invading bacteria.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":339,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000204852","exclusion_id":"X-ENSG00000204852","identifiers":{"approved_symbol":"TCTN1","ensembl_gene_id":"ENSG00000204852"},"preferred_label":"TCTN1","reconciliation":{"canonical_uniprot_accessions":["Q2MV58"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q2MV58","entry_name":"TECT1_HUMAN","gene_names":"TCTN1 TECT1 UNQ9369/PRO34160","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"SIGNAL 1..22; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}. 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Localizes at the transition zone, a region between the basal body and the ciliary axoneme. {ECO:0000250}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":340,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000040275","exclusion_id":"X-ENSG00000040275","identifiers":{"approved_symbol":"SPDL1","ensembl_gene_id":"ENSG00000040275"},"preferred_label":"SPDL1","reconciliation":{"canonical_uniprot_accessions":["Q96EA4"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q96EA4","entry_name":"SPDLY_HUMAN","gene_names":"SPDL1 CCDC99","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Nucleus. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the nucleus in interphase and to the kinetochore in early prometaphase. Relocalizes to the mitotic spindle pole before metaphase and is subsequently lost from the spindle poles after chromosome congression is completed. Removal of this protein from the kinetochore requires the dynein/dynactin complex.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":341,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000104918","exclusion_id":"X-ENSG00000104918","identifiers":{"approved_symbol":"RETN","ensembl_gene_id":"ENSG00000104918"},"preferred_label":"RETN","reconciliation":{"canonical_uniprot_accessions":["Q9HD89"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q9HD89","entry_name":"RETN_HUMAN","gene_names":"RETN FIZZ3 HXCP1 RSTN UNQ407/PRO1199","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"SIGNAL 1..18; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q99P87}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":342,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000143416","exclusion_id":"X-ENSG00000143416","identifiers":{"approved_symbol":"SELENBP1","ensembl_gene_id":"ENSG00000143416"},"preferred_label":"SELENBP1","reconciliation":{"canonical_uniprot_accessions":["Q13228"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q13228","entry_name":"SBP1_HUMAN","gene_names":"SELENBP1 SBP","lipidation":"","provisional_surface_signal":"membrane-only","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14991897}. Cytoplasm, cytosol {ECO:0000269|PubMed:14991897, ECO:0000269|PubMed:16223876}. Membrane {ECO:0000250|UniProtKB:Q8VIF7}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8VIF7}. Note=May associate with Golgi membrane (By similarity). May associate with the membrane of autophagosomes (By similarity). {ECO:0000250|UniProtKB:Q8VIF7}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"membrane-only","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":343,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000146205","identifiers":{"approved_symbol":"ANO7","ensembl_gene_id":"ENSG00000146205"},"preferred_label":"ANO7","reconciliation":{"canonical_uniprot_accessions":["Q6IWH7"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000146205","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q6IWH7","entry_name":"ANO7_HUMAN","gene_names":"ANO7 NGEP PCANAP5 TMEM16G","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:14981236, ECO:0000269|PubMed:17308099, ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:22946059}; Multi-pass membrane protein {ECO:0000255}. Cell junction {ECO:0000269|PubMed:17308099}. Endoplasmic reticulum {ECO:0000269|PubMed:22075693}. Note=Concentrates at sites of cell-cell contact (PubMed:17308099). Shows an intracellular localization according to PubMed:22075693 and PubMed:20056604. {ECO:0000269|PubMed:17308099, ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:22075693}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytosol {ECO:0000269|PubMed:14981236}.","topological_domain":"TOPO_DOM 1..355; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 377..420; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 442..499; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 521..550; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 572..588; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 610..714; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 736..763; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 785..843; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 865..933; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 356..376; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 421..441; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 500..520; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 551..571; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 589..609; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 715..735; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 764..784; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 844..864; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":344,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000165125","identifiers":{"approved_symbol":"TRPV6","ensembl_gene_id":"ENSG00000165125"},"preferred_label":"TRPV6","reconciliation":{"canonical_uniprot_accessions":["Q9H1D0"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000165125","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q9H1D0","entry_name":"TRPV6_HUMAN","gene_names":"TRPV6 ECAC2","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11097838, ECO:0000269|PubMed:11248124, ECO:0000269|PubMed:11278579, ECO:0000269|PubMed:15184369, ECO:0000269|PubMed:23612980, ECO:0000269|PubMed:29258289, ECO:0000269|PubMed:29861107}; Multi-pass membrane protein {ECO:0000269|PubMed:29258289}.","topological_domain":"TOPO_DOM 1..367; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000305|PubMed:29258289\"; TOPO_DOM 389..425; /note=\"Extracellular\"; /evidence=\"ECO:0000305|PubMed:29258289\"; TOPO_DOM 449..463; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000305|PubMed:29258289\"; TOPO_DOM 484..489; /note=\"Extracellular\"; /evidence=\"ECO:0000305|PubMed:29258289\"; TOPO_DOM 510..529; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000305|PubMed:29258289\"; TOPO_DOM 553..565; /note=\"Extracellular\"; /evidence=\"ECO:0000305|PubMed:29258289\"; TOPO_DOM 586..596; /note=\"Extracellular\"; /evidence=\"ECO:0000305|PubMed:29258289\"; TOPO_DOM 618..765; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000305|PubMed:29258289\"","transmembrane":"TRANSMEM 368..388; /note=\"Helical\"; /evidence=\"ECO:0000305|PubMed:29258289\"; TRANSMEM 426..448; /note=\"Helical\"; /evidence=\"ECO:0000305|PubMed:29258289\"; TRANSMEM 464..483; /note=\"Helical\"; /evidence=\"ECO:0000305|PubMed:29258289\"; TRANSMEM 490..509; /note=\"Helical\"; /evidence=\"ECO:0000305|PubMed:29258289\"; TRANSMEM 530..552; /note=\"Helical\"; /evidence=\"ECO:0000305|PubMed:29258289\"; TRANSMEM 597..617; /note=\"Helical\"; /evidence=\"ECO:0000305|PubMed:29258289\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":345,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000215301","identifiers":{"approved_symbol":"DDX3X","ensembl_gene_id":"ENSG00000215301"},"preferred_label":"DDX3X","reconciliation":{"canonical_uniprot_accessions":["O00571"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"extracellular-accessibility-unresolved","reasons":["A membrane or cell-surface localization is reported, but extracellular orientation or anchoring is unresolved."],"state":"unresolved","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"unresolved","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"O00571","entry_name":"DDX3X_HUMAN","gene_names":"DDX3X DBX DDX3","lipidation":"","provisional_surface_signal":"plasma-membrane-annotation","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23413191, ECO:0000269|PubMed:29899501}. Nucleus {ECO:0000269|PubMed:10329544, ECO:0000269|PubMed:15507209, ECO:0000269|PubMed:16818630, ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:18636090, ECO:0000269|PubMed:22034099, ECO:0000269|PubMed:29899501, ECO:0000269|PubMed:30131165, ECO:0000269|PubMed:31575075}. Cytoplasm {ECO:0000269|PubMed:10329544, ECO:0000269|PubMed:15507209, ECO:0000269|PubMed:16818630, ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:18636090, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:21730191, ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:22034099, ECO:0000269|PubMed:23413191, ECO:0000269|PubMed:27105836, ECO:0000269|PubMed:27736973, ECO:0000269|PubMed:28733330, ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29222110, ECO:0000269|PubMed:30131165, ECO:0000269|PubMed:30341167, ECO:0000269|PubMed:31575075, ECO:0000269|PubMed:33674311}. Cytoplasm, Stress granule {ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:18632687, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:29062139}. Inflammasome {ECO:0000250|UniProtKB:Q62167}. Cell projection, lamellipodium {ECO:0000269|PubMed:28733330}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:28842590}. Note=Shuttles between the nucleus and the cytosol (PubMed:15507209, PubMed:18636090, PubMed:29899501, PubMed:30131165, PubMed:31575075). Exported from the nucleus partly through the XPO1/CRM1 system and partly through NXF1/TAP (PubMed:15507209, PubMed:18596238, PubMed:18636090, PubMed:30131165, PubMed:31575075). Localizes to nuclear pores on the outer side of the nuclear membrane (PubMed:15507209). In the cytosol, partly colocalizes with mitochondria (PubMed:20127681). At G0, predominantly located in nucleus. In G1/S phase, predominantly cytoplasmic (PubMed:22034099). During prophase/prometaphase, localizes in close proximity to the condensing chromosomes (PubMed:21730191, PubMed:30131165). During telophase, localizes around the newly synthesized nuclear membrane and in the cytoplasm (PubMed:22034099). Colocalizes with TRPV4 at the plasma membrane. When TRPV4 channel is activated, intracellular Ca(2+) levels increase and the calmodulin/CAMKII pathway is activated, relocalizes to the nucleus (PubMed:29899501). WNT3A stimulation promotes DDX3 recruitment to the plasma membrane (PubMed:23413191). At the leading edge of migrating fibroblasts, colocalizes with CAPRIN1 and PABPC1 (PubMed:28733330). Localizes to centrosome throughout the cell cycle and associates with TP53 at centrosome during mitosis (PubMed:28842590). Translocates to the nucleus in response to HPIV-3 virus-mediated infection (PubMed:31575075). {ECO:0000269|PubMed:15507209, ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:18636090, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:21730191, ECO:0000269|PubMed:22034099, ECO:0000269|PubMed:23413191, ECO:0000269|PubMed:28733330, ECO:0000269|PubMed:28842590, ECO:0000269|PubMed:29899501, ECO:0000269|PubMed:30131165, ECO:0000269|PubMed:31575075}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"plasma-membrane-annotation","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":346,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets 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adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000065978","exclusion_id":"X-ENSG00000065978","identifiers":{"approved_symbol":"YBX1","ensembl_gene_id":"ENSG00000065978"},"preferred_label":"YBX1","reconciliation":{"canonical_uniprot_accessions":["P67809"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P67809","entry_name":"YBOX1_HUMAN","gene_names":"YBX1 NSEP1 YB1","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12604611, ECO:0000269|PubMed:14718551, ECO:0000269|PubMed:15806160}. Nucleus {ECO:0000269|PubMed:12604611, ECO:0000269|PubMed:14718551, ECO:0000269|PubMed:15806160}. Cytoplasmic granule {ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:18335541, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:25229427}. Secreted {ECO:0000269|PubMed:19483673}. Secreted, extracellular exosome {ECO:0000269|PubMed:27559612, ECO:0000269|PubMed:28341602}. Cytoplasm, P-body {ECO:0000250|UniProtKB:P62960}. Note=Predominantly cytoplasmic in proliferating cells (PubMed:12604611). Cytotoxic stress and DNA damage enhance translocation to the nucleus (PubMed:14718551). Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:25229427). Shuttles between nucleus and cytoplasm (PubMed:25229427). Localized with DDX1, MBNL1 and TIAL1 in stress granules upon stress (PubMed:18335541). Secreted by mesangial and monocytic cells after inflammatory challenges (PubMed:19483673). {ECO:0000269|PubMed:12604611, ECO:0000269|PubMed:14718551, ECO:0000269|PubMed:18335541, ECO:0000269|PubMed:19483673, ECO:0000269|PubMed:25229427}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":351,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000138413","exclusion_id":"X-ENSG00000138413","identifiers":{"approved_symbol":"IDH1","ensembl_gene_id":"ENSG00000138413"},"preferred_label":"IDH1","reconciliation":{"canonical_uniprot_accessions":["O75874"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"O75874","entry_name":"IDHC_HUMAN","gene_names":"IDH1 PICD","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10521434}. Peroxisome {ECO:0000269|PubMed:10521434}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":352,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000204618","exclusion_id":"X-ENSG00000204618","identifiers":{"approved_symbol":"RNF39","ensembl_gene_id":"ENSG00000204618"},"preferred_label":"RNF39","reconciliation":{"canonical_uniprot_accessions":["Q9H2S5"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q9H2S5","entry_name":"RNF39_HUMAN","gene_names":"RNF39 HZFW","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:33674311}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":353,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000261371","identifiers":{"approved_symbol":"PECAM1","ensembl_gene_id":"ENSG00000261371"},"preferred_label":"PECAM1","reconciliation":{"canonical_uniprot_accessions":["P16284"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000261371","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P16284","entry_name":"PECA1_HUMAN","gene_names":"PECAM1","lipidation":"LIPID 622; /note=\"S-palmitoyl cysteine\"; /evidence=\"ECO:0000269|PubMed:17139370\"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..27","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17580308}; Single-pass type I membrane protein {ECO:0000305}. Note=Cell surface expression on neutrophils is down-regulated upon fMLP or CXCL8/IL8-mediated stimulation. {ECO:0000269|PubMed:17580308}.; SUBCELLULAR LOCATION: [Isoform Long]: Cell membrane {ECO:0000269|PubMed:18388311, ECO:0000269|PubMed:19342684}; Single-pass type I membrane protein {ECO:0000305|PubMed:18388311}. Membrane raft {ECO:0000269|PubMed:17139370, ECO:0000269|PubMed:22496122}. Cell junction {ECO:0000269|PubMed:18388311}. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells. {ECO:0000269|PubMed:19342684}.; SUBCELLULAR LOCATION: [Isoform Delta15]: Cell junction {ECO:0000269|PubMed:18388311}. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.","topological_domain":"TOPO_DOM 28..601; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 621..738; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 602..620; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":354,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000169605","exclusion_id":"X-ENSG00000169605","identifiers":{"approved_symbol":"GKN1","ensembl_gene_id":"ENSG00000169605"},"preferred_label":"GKN1","reconciliation":{"canonical_uniprot_accessions":["Q9NS71"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q9NS71","entry_name":"GKN1_HUMAN","gene_names":"GKN1 AMP18 CA11 UNQ489/PRO1005","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"SIGNAL 1..20; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15221938}. Cytoplasmic granule {ECO:0000269|PubMed:15221938}. Golgi apparatus {ECO:0000305|PubMed:15221938}. Note=Shows abundant granular cytoplasmic staining, with perinuclear accentuation suggestive of the Golgi apparatus. {ECO:0000269|PubMed:15221938}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":355,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000206047","exclusion_id":"X-ENSG00000206047","identifiers":{"approved_symbol":"DEFA1","ensembl_gene_id":"ENSG00000206047"},"preferred_label":"DEFA1","reconciliation":{"canonical_uniprot_accessions":["P59665"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P59665","entry_name":"DEF1_HUMAN","gene_names":"DEFA1 DEF1 DEFA2 MRS; DEFA1B","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"SIGNAL 1..19; /evidence=\"ECO:0000269|PubMed:15340161\"","subcellular_location":"SUBCELLULAR LOCATION: Secreted.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":356,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000137674","identifiers":{"approved_symbol":"MMP20","ensembl_gene_id":"ENSG00000137674"},"preferred_label":"MMP20","reconciliation":{"canonical_uniprot_accessions":["O60882"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"extracellular-matrix-retention-accessibility-unresolved","reasons":["Canonical reviewed UniProt explicitly reports extracellular-matrix localization, which is within the broad extracellular target scope.","Disease-site retention, extracellular accessibility, and cell of origin require review before retaining this as an actionable matrix target; it is not an intracellular or soluble-only exclusion."],"state":"unresolved","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"unresolved","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"O60882","entry_name":"MMP20_HUMAN","gene_names":"MMP20","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"SIGNAL 1..22; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.","topological_domain":"","transmembrane":""},{"accession":"Q9NPA2","entry_name":"MMP25_HUMAN","gene_names":"MMP25 MMP20 MMPL1 MT6MMP","lipidation":"LIPID 539; /note=\"GPI-anchor amidated alanine\"; /evidence=\"ECO:0000255\"","provisional_surface_signal":"plasma-membrane-annotation","signal_peptide":"SIGNAL 1..21; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"plasma-membrane-annotation","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":357,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000253729","exclusion_id":"X-ENSG00000253729","identifiers":{"approved_symbol":"PRKDC","ensembl_gene_id":"ENSG00000253729"},"preferred_label":"PRKDC","reconciliation":{"canonical_uniprot_accessions":["P78527"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P78527","entry_name":"PRKDC_HUMAN","gene_names":"PRKDC HYRC HYRC1","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12231622, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:22002106}. Nucleus, nucleolus {ECO:0000269|PubMed:22002106, ECO:0000269|PubMed:32103174}. Cytoplasm, cytosol {ECO:0000269|PubMed:15262962}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":358,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000186160","exclusion_id":"X-ENSG00000186160","identifiers":{"approved_symbol":"CYP4Z1","ensembl_gene_id":"ENSG00000186160"},"preferred_label":"CYP4Z1","reconciliation":{"canonical_uniprot_accessions":["Q86W10"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q86W10","entry_name":"CP4Z1_HUMAN","gene_names":"CYP4Z1 UNQ3060/PRO9882","lipidation":"","provisional_surface_signal":"membrane-only","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15059886}; Single-pass type II membrane protein {ECO:0000269|PubMed:15059886}. Microsome membrane {ECO:0000269|PubMed:15059886}; Single-pass type II membrane protein {ECO:0000269|PubMed:15059886}.","topological_domain":"TOPO_DOM 1..9; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 31..505; /note=\"Lumenal\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 10..30; /note=\"Helical; Signal-anchor for type II membrane protein\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"membrane-only","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":359,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000107643","exclusion_id":"X-ENSG00000107643","identifiers":{"approved_symbol":"MAPK8","ensembl_gene_id":"ENSG00000107643"},"preferred_label":"MAPK8","reconciliation":{"canonical_uniprot_accessions":["P45983"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P45983","entry_name":"MK08_HUMAN","gene_names":"MAPK8 JNK1 PRKM8 SAPK1 SAPK1C","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21148294}. Nucleus {ECO:0000269|PubMed:21148294, ECO:0000269|PubMed:30878395}. Synapse {ECO:0000250|UniProtKB:P49185}. Note=In the cortical neurons, predominantly cytoplasmic and associated with the Golgi apparatus and endosomal fraction. Increased neuronal activity increases phosphorylated form at synapses (By similarity). Colocalizes with POU5F1 in the nucleus. {ECO:0000250|UniProtKB:P49185, ECO:0000250|UniProtKB:Q91Y86}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":360,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000133321","exclusion_id":"X-ENSG00000133321","identifiers":{"approved_symbol":"PLAAT4","ensembl_gene_id":"ENSG00000133321"},"preferred_label":"PLAAT4","reconciliation":{"canonical_uniprot_accessions":["Q9UL19"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q9UL19","entry_name":"PLAT4_HUMAN","gene_names":"PLAAT4 RARRES3 RIG1 TIG3","lipidation":"","provisional_surface_signal":"membrane-only","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.","topological_domain":"TOPO_DOM 1..134; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 156..164; /note=\"Lumenal\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 135..155; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"membrane-only","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":361,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000112242","exclusion_id":"X-ENSG00000112242","identifiers":{"approved_symbol":"E2F3","ensembl_gene_id":"ENSG00000112242"},"preferred_label":"E2F3","reconciliation":{"canonical_uniprot_accessions":["O00716"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"O00716","entry_name":"E2F3_HUMAN","gene_names":"E2F3 KIAA0075","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":362,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000011201","identifiers":{"approved_symbol":"ANOS1","ensembl_gene_id":"ENSG00000011201"},"preferred_label":"ANOS1","reconciliation":{"canonical_uniprot_accessions":["P23352"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"conflicting-surface-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt localization places the canonical protein on the cytoplasmic face or as a peripheral membrane protein."],"state":"unresolved","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"unresolved","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P23352","entry_name":"KALM_HUMAN","gene_names":"ANOS1 ADMLX KAL KAL1 KALIG1","lipidation":"","provisional_surface_signal":"plasma-membrane-annotation","signal_peptide":"SIGNAL 1..24; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8842728}; Peripheral membrane protein {ECO:0000269|PubMed:8842728}. Secreted {ECO:0000269|PubMed:8842728}. Note=Proteolytic cleavage may release it from the cell surface into the extracellular space.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"plasma-membrane-annotation","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":363,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000162390","exclusion_id":"X-ENSG00000162390","identifiers":{"approved_symbol":"ACOT11","ensembl_gene_id":"ENSG00000162390"},"preferred_label":"ACOT11","reconciliation":{"canonical_uniprot_accessions":["Q8WXI4"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q8WXI4","entry_name":"ACO11_HUMAN","gene_names":"ACOT11 BFIT KIAA0707 THEA","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:22897136}. Cytoplasm {ECO:0000269|PubMed:22897136}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":364,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000189377","exclusion_id":"X-ENSG00000189377","identifiers":{"approved_symbol":"CXCL17","ensembl_gene_id":"ENSG00000189377"},"preferred_label":"CXCL17","reconciliation":{"canonical_uniprot_accessions":["Q6UXB2"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q6UXB2","entry_name":"CXL17_HUMAN","gene_names":"CXCL17 VCC1 UNQ473/PRO842","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"SIGNAL 1..21; 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Cell membrane {ECO:0000269|PubMed:12163475}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"plasma-membrane-annotation","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":367,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000135679","exclusion_id":"X-ENSG00000135679","identifiers":{"approved_symbol":"MDM2","ensembl_gene_id":"ENSG00000135679"},"preferred_label":"MDM2","reconciliation":{"canonical_uniprot_accessions":["Q00987"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q00987","entry_name":"MDM2_HUMAN","gene_names":"MDM2","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:10707090}. Cytoplasm {ECO:0000269|PubMed:30879903, ECO:0000269|PubMed:36897777}. Nucleus, nucleolus {ECO:0000269|PubMed:10707090}. Nucleus {ECO:0000269|PubMed:30879903, ECO:0000269|PubMed:36897777}. Note=Expressed predominantly in the nucleoplasm. Interaction with ARF(P14) results in the localization of both proteins to the nucleolus. The nucleolar localization signals in both ARF(P14) and MDM2 may be necessary to allow efficient nucleolar localization of both proteins. Colocalizes with RASSF1 isoform A in the nucleus.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":368,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000177455","identifiers":{"approved_symbol":"CD19","ensembl_gene_id":"ENSG00000177455"},"preferred_label":"CD19","reconciliation":{"canonical_uniprot_accessions":["P15391"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000177455","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P15391","entry_name":"CD19_HUMAN","gene_names":"CD19","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..19; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1373518, ECO:0000269|PubMed:1383329, ECO:0000269|PubMed:16672701, ECO:0000269|PubMed:1702139, ECO:0000269|PubMed:2463100, ECO:0000269|PubMed:9317126, ECO:0000269|PubMed:9382888}; Single-pass type I membrane protein {ECO:0000305}. Membrane raft {ECO:0000250|UniProtKB:P25918}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P25918}.","topological_domain":"TOPO_DOM 20..291; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 314..556; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 292..313; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":369,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000136450","exclusion_id":"X-ENSG00000136450","identifiers":{"approved_symbol":"SRSF1","ensembl_gene_id":"ENSG00000136450"},"preferred_label":"SRSF1","reconciliation":{"canonical_uniprot_accessions":["Q07955"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q07955","entry_name":"SRSF1_HUMAN","gene_names":"SRSF1 ASF SF2 SF2P33 SFRS1 OK/SW-cl.3","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:37595559}. Cytoplasm {ECO:0000269|PubMed:12215544, ECO:0000269|PubMed:20308322, ECO:0000269|PubMed:24449914, ECO:0000269|PubMed:9420331}. Nucleus speckle {ECO:0000269|PubMed:12215544, ECO:0000269|PubMed:20308322, ECO:0000269|PubMed:24449914, ECO:0000269|PubMed:24644279, ECO:0000269|PubMed:9420331}. Note=In nuclear speckles. Shuttles between the nucleus and the cytoplasm (PubMed:12215544, PubMed:20308322, PubMed:24449914, PubMed:9420331). Nuclear import is mediated via interaction with TNPO3 (PubMed:24449914). {ECO:0000269|PubMed:12215544, ECO:0000269|PubMed:20308322, ECO:0000269|PubMed:24449914, ECO:0000269|PubMed:9420331}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":370,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000076984","exclusion_id":"X-ENSG00000076984","identifiers":{"approved_symbol":"MAP2K7","ensembl_gene_id":"ENSG00000076984"},"preferred_label":"MAP2K7","reconciliation":{"canonical_uniprot_accessions":["O14733"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"O14733","entry_name":"MP2K7_HUMAN","gene_names":"MAP2K7 JNKK2 MEK7 MKK7 PRKMK7 SKK4","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus. 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Secreted {ECO:0000269|PubMed:20018874}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":373,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous 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672..689; /note=\"Helical; Name=12\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":374,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous 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Colocalizes with MTTP in the endoplasmic reticulum (PubMed:23475612). {ECO:0000269|PubMed:10636893, ECO:0000269|PubMed:11181151, ECO:0000269|PubMed:23475612, ECO:0000305}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"plasma-membrane-annotation","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":395,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000151623","exclusion_id":"X-ENSG00000151623","identifiers":{"approved_symbol":"NR3C2","ensembl_gene_id":"ENSG00000151623"},"preferred_label":"NR3C2","reconciliation":{"canonical_uniprot_accessions":["P08235"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P08235","entry_name":"MCR_HUMAN","gene_names":"NR3C2 MCR MLR","lipidation":"","provisional_surface_signal":"membrane-only","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Cytoplasmic and nuclear in the absence of ligand; nuclear after ligand-binding. When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"membrane-only","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":396,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000171345","identifiers":{"approved_symbol":"KRT19","ensembl_gene_id":"ENSG00000171345"},"preferred_label":"KRT19","reconciliation":{"canonical_uniprot_accessions":["P08727"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"localization-unresolved","reasons":["The canonical reviewed UniProt entry has no decisive localization annotation."],"state":"unresolved","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"unresolved","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P08727","entry_name":"K1C19_HUMAN","gene_names":"KRT19","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":397,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000069424","exclusion_id":"X-ENSG00000069424","identifiers":{"approved_symbol":"KCNAB2","ensembl_gene_id":"ENSG00000069424"},"preferred_label":"KCNAB2","reconciliation":{"canonical_uniprot_accessions":["Q13303"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-cytoplasmic-face-or-peripheral-membrane","reasons":["Reviewed UniProt places the canonical protein on the cytoplasmic face or as a peripheral membrane protein without an extracellular domain."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q13303","entry_name":"KCAB2_HUMAN","gene_names":"KCNAB2 KCNA2B KCNK2","lipidation":"","provisional_surface_signal":"plasma-membrane-annotation","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P62483}. 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Associates with microtubules when unphosphorylated. {ECO:0000250|UniProtKB:P62483}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"plasma-membrane-annotation","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":398,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000084774","exclusion_id":"X-ENSG00000084774","identifiers":{"approved_symbol":"CAD","ensembl_gene_id":"ENSG00000084774"},"preferred_label":"CAD","reconciliation":{"canonical_uniprot_accessions":["P27708"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"O76075","entry_name":"DFFB_HUMAN","gene_names":"DFFB CAD DFF2 DFF40","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cytoplasm. 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Note=On thin filaments in smooth muscle and on stress fibers in fibroblasts (nonmuscle). {ECO:0000250|UniProtKB:P13505}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":399,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000163735","exclusion_id":"X-ENSG00000163735","identifiers":{"approved_symbol":"CXCL5","ensembl_gene_id":"ENSG00000163735"},"preferred_label":"CXCL5","reconciliation":{"canonical_uniprot_accessions":["P42830"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P42830","entry_name":"CXCL5_HUMAN","gene_names":"CXCL5 ENA78 SCYB5","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"SIGNAL 1..36; /evidence=\"ECO:0000269|PubMed:10095777, ECO:0000269|PubMed:12665801\"","subcellular_location":"SUBCELLULAR LOCATION: Secreted.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":400,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000140943","exclusion_id":"X-ENSG00000140943","identifiers":{"approved_symbol":"MBTPS1","ensembl_gene_id":"ENSG00000140943"},"preferred_label":"MBTPS1","reconciliation":{"canonical_uniprot_accessions":["Q14703"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q14703","entry_name":"MBTP1_HUMAN","gene_names":"MBTPS1 KIAA0091 S1P SKI1","lipidation":"","provisional_surface_signal":"membrane-only","signal_peptide":"SIGNAL 1..17","subcellular_location":"SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:9990022}; Single-pass type I membrane protein {ECO:0000269|PubMed:9990022}. Golgi apparatus membrane {ECO:0000269|PubMed:34349020, ECO:0000269|PubMed:9990022}; Single-pass type I membrane protein {ECO:0000269|PubMed:9990022}. Secreted {ECO:0000269|PubMed:9990022}. Mitochondrion {ECO:0000269|PubMed:35362222}. Note=May sort to other organelles, including lysosomal and/or endosomal compartments. The 98 kDa form is secreted. {ECO:0000269|PubMed:9990022}.","topological_domain":"TOPO_DOM 187..998; /note=\"Lumenal\"; /evidence=\"ECO:0000255\"; TOPO_DOM 1022..1052; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 999..1021; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"membrane-only","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":401,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"gene","entity_id":"E-OT-MONDO_0005007-ENSG00000245532","exclusion_id":"X-ENSG00000245532","identifiers":{"approved_symbol":"NEAT1","ensembl_gene_id":"ENSG00000245532"},"preferred_label":"NEAT1","reconciliation":{"canonical_uniprot_accessions":[],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"non-protein-gene-record","reasons":["Open Targets biotype is not protein-coding."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":402,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000049540","identifiers":{"approved_symbol":"ELN","ensembl_gene_id":"ENSG00000049540"},"preferred_label":"ELN","reconciliation":{"canonical_uniprot_accessions":["P15502"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"extracellular-matrix-retention-accessibility-unresolved","reasons":["Canonical reviewed UniProt explicitly reports extracellular-matrix localization, which is within the broad extracellular target scope.","Disease-site retention, extracellular accessibility, and cell of origin require review before retaining this as an actionable matrix target; it is not an intracellular or soluble-only exclusion."],"state":"unresolved","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"unresolved","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P15502","entry_name":"ELN_HUMAN","gene_names":"ELN","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"SIGNAL 1..26; /evidence=\"ECO:0000250|UniProtKB:Q99372\"","subcellular_location":"SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:17035250}. 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Cytoplasm {ECO:0000269|PubMed:22566094}. Perikaryon {ECO:0000250|UniProtKB:Q9Z0W1}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q9Z0W1}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q9Z0W1}.","topological_domain":"TOPO_DOM 29..250; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 273..427; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 251..272; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":404,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000204371","exclusion_id":"X-ENSG00000204371","identifiers":{"approved_symbol":"EHMT2","ensembl_gene_id":"ENSG00000204371"},"preferred_label":"EHMT2","reconciliation":{"canonical_uniprot_accessions":["Q96KQ7"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q96KQ7","entry_name":"EHMT2_HUMAN","gene_names":"EHMT2 BAT8 C6orf30 G9A KMT1C NG36","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11316813}. Chromosome {ECO:0000269|PubMed:11316813}. Note=Associates with euchromatic regions (PubMed:11316813). Does not associate with heterochromatin (PubMed:11316813). {ECO:0000269|PubMed:11316813}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":405,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000159674","identifiers":{"approved_symbol":"SPON2","ensembl_gene_id":"ENSG00000159674"},"preferred_label":"SPON2","reconciliation":{"canonical_uniprot_accessions":["Q9BUD6"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"extracellular-matrix-retention-accessibility-unresolved","reasons":["Canonical reviewed UniProt explicitly reports extracellular-matrix localization, which is within the broad extracellular target scope.","Disease-site retention, extracellular accessibility, and cell of origin require review before retaining this as an actionable matrix target; it is not an intracellular or soluble-only exclusion."],"state":"unresolved","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"unresolved","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q9BUD6","entry_name":"SPON2_HUMAN","gene_names":"SPON2 DIL1 UNQ435/PRO866","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"SIGNAL 1..26; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":406,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000196419","exclusion_id":"X-ENSG00000196419","identifiers":{"approved_symbol":"XRCC6","ensembl_gene_id":"ENSG00000196419"},"preferred_label":"XRCC6","reconciliation":{"canonical_uniprot_accessions":["P12956"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P12956","entry_name":"XRCC6_HUMAN","gene_names":"XRCC6 G22P1","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15023334, ECO:0000269|PubMed:22442688, ECO:0000269|PubMed:35545041}. Chromosome {ECO:0000269|PubMed:22442688}. Cytoplasm {ECO:0000269|PubMed:15023334, ECO:0000269|PubMed:35545041}. Note=When trimethylated, localizes in the cytoplasm. {ECO:0000269|PubMed:35545041}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":407,"datasource_scores":[{"id":"europepmc","score":0.030396539880581056}],"score":0.0036957985468470188,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000116852","exclusion_id":"X-ENSG00000116852","identifiers":{"approved_symbol":"KIF21B","ensembl_gene_id":"ENSG00000116852"},"preferred_label":"KIF21B","reconciliation":{"canonical_uniprot_accessions":["O75037"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"O75037","entry_name":"KI21B_HUMAN","gene_names":"KIF21B KIAA0449","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9QXL1}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9QXL1}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q9QXL1}. Cell projection, axon {ECO:0000250|UniProtKB:Q9QXL1}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:F1M5N7}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":408,"datasource_scores":[{"id":"europepmc","score":0.030227670214577826}],"score":0.003675266332697868,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000181449","exclusion_id":"X-ENSG00000181449","identifiers":{"approved_symbol":"SOX2","ensembl_gene_id":"ENSG00000181449"},"preferred_label":"SOX2","reconciliation":{"canonical_uniprot_accessions":["P48431"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P48431","entry_name":"SOX2_HUMAN","gene_names":"SOX2","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250|UniProtKB:Q05066}. Cytoplasm {ECO:0000250|UniProtKB:Q05738}. Nucleus {ECO:0000250|UniProtKB:Q05738}. Note=Acetylation contributes to its nuclear localization and deacetylation by HDAC3 induces a cytoplasmic delocalization (By similarity). Colocalizes in the nucleus with ZNF208 isoform KRAB-O and tyrosine hydroxylase (TH) (By similarity). Colocalizes with SOX6 in speckles. Colocalizes with CAML in the nucleus (By similarity). Nuclear import is facilitated by XPO4, a protein that usually acts as a nuclear export signal receptor (By similarity). {ECO:0000250|UniProtKB:Q05066, ECO:0000250|UniProtKB:Q05738}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":409,"datasource_scores":[{"id":"europepmc","score":0.028876712886552}],"score":0.0035110086195046675,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000131981","identifiers":{"approved_symbol":"LGALS3","ensembl_gene_id":"ENSG00000131981"},"preferred_label":"LGALS3","reconciliation":{"canonical_uniprot_accessions":["P17931"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"extracellular-accessibility-unresolved","reasons":["A membrane or cell-surface localization is reported, but extracellular orientation or anchoring is unresolved."],"state":"unresolved","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"unresolved","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P17931","entry_name":"LEG3_HUMAN","gene_names":"LGALS3 MAC2","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:32272059}. Nucleus. Secreted {ECO:0000269|PubMed:32272059}. Note=Secreted by a non-classical secretory pathway and associates with the cell surface. Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059). {ECO:0000269|PubMed:32272059}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":410,"datasource_scores":[{"id":"europepmc","score":0.02870784322054877}],"score":0.003490476405355517,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000176890","exclusion_id":"X-ENSG00000176890","identifiers":{"approved_symbol":"TYMS","ensembl_gene_id":"ENSG00000176890"},"preferred_label":"TYMS","reconciliation":{"canonical_uniprot_accessions":["P04818"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P04818","entry_name":"TYSY_HUMAN","gene_names":"TYMS TS OK/SW-cl.29","lipidation":"","provisional_surface_signal":"membrane-only","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21876188, ECO:0000269|PubMed:22235121}. Cytoplasm {ECO:0000269|PubMed:21876188}. Mitochondrion {ECO:0000269|PubMed:21876188}. Mitochondrion matrix {ECO:0000269|PubMed:21876188}. Mitochondrion inner membrane {ECO:0000269|PubMed:21876188}. Note=Localized to the nucleus during S and G2/M phases of the cell cycle. 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Note=Distributed throughout the cytoplasm during mitosis, accumulating at spindle poles.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":422,"datasource_scores":[{"id":"europepmc","score":0.024317231904464845}],"score":0.0029566388374776143,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000143476","exclusion_id":"X-ENSG00000143476","identifiers":{"approved_symbol":"DTL","ensembl_gene_id":"ENSG00000143476"},"preferred_label":"DTL","reconciliation":{"canonical_uniprot_accessions":["Q9NZJ0"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q9NZJ0","entry_name":"DTL_HUMAN","gene_names":"DTL CDT2 CDW1 DCAF2 L2DTL RAMP","lipidation":"","provisional_surface_signal":"membrane-only","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26431207}. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome. Note=Nuclear matrix-associated protein. Translocates from the interphase nucleus to the metaphase cytoplasm during mitosis.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"membrane-only","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":423,"datasource_scores":[{"id":"europepmc","score":0.024317231904464845}],"score":0.0029566388374776143,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000164736","exclusion_id":"X-ENSG00000164736","identifiers":{"approved_symbol":"SOX17","ensembl_gene_id":"ENSG00000164736"},"preferred_label":"SOX17","reconciliation":{"canonical_uniprot_accessions":["Q9H6I2"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q9H6I2","entry_name":"SOX17_HUMAN","gene_names":"SOX17","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":424,"datasource_scores":[{"id":"europepmc","score":0.024148362238461615}],"score":0.0029361066233284643,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000123358","exclusion_id":"X-ENSG00000123358","identifiers":{"approved_symbol":"NR4A1","ensembl_gene_id":"ENSG00000123358"},"preferred_label":"NR4A1","reconciliation":{"canonical_uniprot_accessions":["P22736"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P22736","entry_name":"NR4A1_HUMAN","gene_names":"NR4A1 GFRP1 HMR NAK1","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15509776, ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:18690216, ECO:0000269|PubMed:20438716, ECO:0000269|PubMed:22427340, ECO:0000269|PubMed:22983157, ECO:0000269|PubMed:8121493}. Cytoplasm, cytosol {ECO:0000269|PubMed:15509776, ECO:0000269|PubMed:20438716, ECO:0000269|PubMed:22427340}. Mitochondrion {ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:18690216}. Note=Nuclear export to the cytosol is XPO1-mediated and positively regulated by IFI27 (PubMed:22427340). Translocation to the mitochondrion upon interaction with RXRA and upon the presence of 9-cis retinoic acid (PubMed:17761950). {ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:22427340}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":425,"datasource_scores":[{"id":"europepmc","score":0.02279740491043579}],"score":0.002771848910135263,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000169057","exclusion_id":"X-ENSG00000169057","identifiers":{"approved_symbol":"MECP2","ensembl_gene_id":"ENSG00000169057"},"preferred_label":"MECP2","reconciliation":{"canonical_uniprot_accessions":["P51608"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P51608","entry_name":"MECP2_HUMAN","gene_names":"MECP2","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Z2D6}. Note=Colocalized with methyl-CpG in the genome. Colocalized with TBL1X to the heterochromatin foci. {ECO:0000269|PubMed:28348241}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":426,"datasource_scores":[{"id":"europepmc","score":0.02279740491043579}],"score":0.002771848910135263,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000160180","identifiers":{"approved_symbol":"TFF3","ensembl_gene_id":"ENSG00000160180"},"preferred_label":"TFF3","reconciliation":{"canonical_uniprot_accessions":["Q07654"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"extracellular-matrix-retention-accessibility-unresolved","reasons":["Canonical reviewed UniProt explicitly reports extracellular-matrix localization, which is within the broad extracellular target scope.","Disease-site retention, extracellular accessibility, and cell of origin require review before retaining this as an actionable matrix target; it is not an intracellular or soluble-only exclusion."],"state":"unresolved","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"unresolved","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q07654","entry_name":"TFF3_HUMAN","gene_names":"TFF3 ITF TFI","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"SIGNAL 1..21; /evidence=\"ECO:0000269|PubMed:15340161, ECO:0000269|PubMed:19670903\"","subcellular_location":"SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:8454642}. Cytoplasm {ECO:0000269|PubMed:10824705, ECO:0000269|PubMed:8454642}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":427,"datasource_scores":[{"id":"europepmc","score":0.02262853524443256}],"score":0.002751316695986113,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000165731","identifiers":{"approved_symbol":"RET","ensembl_gene_id":"ENSG00000165731"},"preferred_label":"RET","query_expansion_seeds":[{"category":"signaling-receptors","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["P07949"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000165731","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P07949","entry_name":"RET_HUMAN","gene_names":"RET CDHF12 CDHR16 PTC","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..28; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19823924, ECO:0000269|PubMed:21994944, ECO:0000269|PubMed:23333276, ECO:0000269|PubMed:28953886, ECO:0000269|PubMed:9575150}; Single-pass type I membrane protein {ECO:0000269|PubMed:19823924}. Endosome membrane {ECO:0000269|PubMed:19823924, ECO:0000269|PubMed:23333276}; Single-pass type I membrane protein {ECO:0000269|PubMed:19823924}. Note=Predominantly located on the plasma membrane (PubMed:23333276, PubMed:9575150). In the presence of SORL1 and GFRA1, directed to endosomes (PubMed:23333276). {ECO:0000269|PubMed:23333276, ECO:0000269|PubMed:9575150}.","topological_domain":"TOPO_DOM 29..635; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 658..1114; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 636..657; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":428,"datasource_scores":[{"id":"europepmc","score":0.02262853524443256}],"score":0.002751316695986113,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000172238","exclusion_id":"X-ENSG00000172238","identifiers":{"approved_symbol":"ATOH1","ensembl_gene_id":"ENSG00000172238"},"preferred_label":"ATOH1","reconciliation":{"canonical_uniprot_accessions":["Q92858"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q92858","entry_name":"ATOH1_HUMAN","gene_names":"ATOH1 ATH1 BHLHA14","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":429,"datasource_scores":[{"id":"europepmc","score":0.021277577916406734}],"score":0.0025870589827929123,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000160181","exclusion_id":"X-ENSG00000160181","identifiers":{"approved_symbol":"TFF2","ensembl_gene_id":"ENSG00000160181"},"preferred_label":"TFF2","reconciliation":{"canonical_uniprot_accessions":["Q03403"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q03403","entry_name":"TFF2_HUMAN","gene_names":"TFF2 SML1","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"SIGNAL 1..23; 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Chromosome {ECO:0000269|PubMed:11673449}. Nucleus envelope {ECO:0000269|PubMed:25083873, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}. Note=Depending on the cell type, it can also be found in PML nuclear bodies (PubMed:12814551). Recruited to chromatin during S-phase (PubMed:14871897). Redistributes to discrete nuclear foci upon DNA damage, hypoxia or replication fork stalling (PubMed:27723720). Relocalizes to the nuclear envelope in response to mechanical stress or DNA damage (PubMed:25083873, PubMed:37832547). Also localizes to the micronuclear envelope in response to response to genome instability (PubMed:37788673). {ECO:0000269|PubMed:12814551, ECO:0000269|PubMed:25083873, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.","topological_domain":"","transmembrane":""},{"accession":"Q9H6X2","entry_name":"ANTR1_HUMAN","gene_names":"ANTXR1 ATR TEM8","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..32; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16762926, ECO:0000269|PubMed:30241478}; Single-pass type I membrane protein {ECO:0000269|PubMed:16762926}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:16762926}; Single-pass type I membrane protein {ECO:0000269|PubMed:16762926}. Cell projection, filopodium membrane {ECO:0000269|PubMed:16762926}; Single-pass type I membrane protein {ECO:0000269|PubMed:16762926}. 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Basolateral cell membrane {ECO:0000269|PubMed:16054130}. Cell junction, tight junction {ECO:0000269|PubMed:16054130}. 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Chromosome, centromere, kinetochore {ECO:0000269|PubMed:32666501, ECO:0000269|PubMed:33094908}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:20034488}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":468,"datasource_scores":[{"id":"europepmc","score":0.01823792392834863}],"score":0.0022174791281082107,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000275395","exclusion_id":"X-ENSG00000275395","identifiers":{"approved_symbol":"FCGBP","ensembl_gene_id":"ENSG00000275395"},"preferred_label":"FCGBP","reconciliation":{"canonical_uniprot_accessions":["Q9Y6R7"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q9Y6R7","entry_name":"FCGBP_HUMAN","gene_names":"FCGBP","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"SIGNAL 1..23; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Secreted {ECO:0000305}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":469,"datasource_scores":[{"id":"europepmc","score":0.01823792392834863}],"score":0.0022174791281082107,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000167772","identifiers":{"approved_symbol":"ANGPTL4","ensembl_gene_id":"ENSG00000167772"},"preferred_label":"ANGPTL4","reconciliation":{"canonical_uniprot_accessions":["Q9BY76"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"extracellular-matrix-retention-accessibility-unresolved","reasons":["Canonical reviewed UniProt explicitly reports extracellular-matrix localization, which is within the broad extracellular target scope.","Disease-site retention, extracellular accessibility, and cell of origin require review before retaining this as an actionable matrix target; it is not an intracellular or soluble-only exclusion."],"state":"unresolved","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"unresolved","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q9BY76","entry_name":"ANGL4_HUMAN","gene_names":"ANGPTL4 ARP4 HFARP PGAR PP1158 PSEC0166 UNQ171/PRO197","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"SIGNAL 1..25; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10698685, ECO:0000269|PubMed:14583458, ECO:0000269|PubMed:17068295, ECO:0000269|PubMed:19270337, ECO:0000269|PubMed:21398697, ECO:0000269|PubMed:29899519}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:17068295, ECO:0000269|PubMed:21398697}. Note=The unprocessed form interacts with the extracellular matrix (PubMed:17068295, PubMed:21398697). 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Note=Golgi membrane, early secretory pathway. {ECO:0000269|PubMed:12855678}.","topological_domain":"TOPO_DOM 1..30; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 49..411; /note=\"Lumenal\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 31..48; /note=\"Helical; Signal-anchor for type II membrane protein\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"membrane-only","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":489,"datasource_scores":[{"id":"europepmc","score":0.01823792392834863}],"score":0.0022174791281082107,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":116484,"filename":"MONDO_0005007-associated-targets.json","sha256":"6385e9eb0fc1df40850114d2c3a352662982b4c1071c97562000e8d25fe22e9a"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000182606","exclusion_id":"X-ENSG00000182606","identifiers":{"approved_symbol":"TRAK1","ensembl_gene_id":"ENSG00000182606"},"preferred_label":"TRAK1","reconciliation":{"canonical_uniprot_accessions":["Q9UPV9"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q9UPV9","entry_name":"TRAK1_HUMAN","gene_names":"TRAK1 KIAA1042 OIP106","lipidation":"","provisional_surface_signal":"membrane-only","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18986759}. Nucleus {ECO:0000269|PubMed:12435728}. Mitochondrion {ECO:0000269|PubMed:15644324, ECO:0000269|PubMed:16630562, ECO:0000269|PubMed:18675823, ECO:0000269|PubMed:19528298}. Early endosome {ECO:0000269|PubMed:18675823}. Endosome {ECO:0000269|PubMed:18675823}. Mitochondrion membrane {ECO:0000269|PubMed:24995978}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q6PD31}. Note=Predominantly associated with early endosome. The localization to early endosomes depends on its interaction with HGS/HRS (PubMed:18675823). 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Note=The 83 N-terminal amino acids function as un uncleaved transit peptide, and arginine residues within it are crucial for mitochondrial localization. {ECO:0000269|PubMed:19269317}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":503,"datasource_scores":[{"id":"europepmc","score":0.015198269940290528}],"score":0.0018478992734235094,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":13503,"filename":"MONDO_0005007-associated-targets-page-2.json","sha256":"26a9df77e260244ca3b7d5d09ea58127fca45365ce5ac3dd036ffb2a38df2b0d"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000101443","exclusion_id":"X-ENSG00000101443","identifiers":{"approved_symbol":"WFDC2","ensembl_gene_id":"ENSG00000101443"},"preferred_label":"WFDC2","reconciliation":{"canonical_uniprot_accessions":["Q14508"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q14508","entry_name":"WFDC2_HUMAN","gene_names":"WFDC2 HE4 WAP5","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"SIGNAL 1..30; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15781627}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":504,"datasource_scores":[{"id":"europepmc","score":0.015198269940290528}],"score":0.0018478992734235094,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":13503,"filename":"MONDO_0005007-associated-targets-page-2.json","sha256":"26a9df77e260244ca3b7d5d09ea58127fca45365ce5ac3dd036ffb2a38df2b0d"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000177575","identifiers":{"approved_symbol":"CD163","ensembl_gene_id":"ENSG00000177575"},"preferred_label":"CD163","reconciliation":{"canonical_uniprot_accessions":["Q86VB7"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000177575","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q86VB7","entry_name":"C163A_HUMAN","gene_names":"CD163 M130","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..41; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: [Soluble CD163]: Secreted {ECO:0000269|PubMed:12296867}.; SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10577520, ECO:0000269|PubMed:10648003}; Single-pass type I membrane protein {ECO:0000269|PubMed:10577520, ECO:0000269|PubMed:10648003}. Note=Isoform 1 and isoform 2 show a lower surface expression when expressed in cells.","topological_domain":"TOPO_DOM 42..1050; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 1072..1156; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 1051..1071; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":505,"datasource_scores":[{"id":"europepmc","score":0.012158615952232422}],"score":0.0014783194187388072,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":13503,"filename":"MONDO_0005007-associated-targets-page-2.json","sha256":"26a9df77e260244ca3b7d5d09ea58127fca45365ce5ac3dd036ffb2a38df2b0d"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000167548","exclusion_id":"X-ENSG00000167548","identifiers":{"approved_symbol":"KMT2D","ensembl_gene_id":"ENSG00000167548"},"preferred_label":"KMT2D","reconciliation":{"canonical_uniprot_accessions":["O14686"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"O14686","entry_name":"KMT2D_HUMAN","gene_names":"KMT2D ALR MLL2 MLL4","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23508102}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":506,"datasource_scores":[{"id":"europepmc","score":0.012158615952232422}],"score":0.0014783194187388072,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":13503,"filename":"MONDO_0005007-associated-targets-page-2.json","sha256":"26a9df77e260244ca3b7d5d09ea58127fca45365ce5ac3dd036ffb2a38df2b0d"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000068903","exclusion_id":"X-ENSG00000068903","identifiers":{"approved_symbol":"SIRT2","ensembl_gene_id":"ENSG00000068903"},"preferred_label":"SIRT2","reconciliation":{"canonical_uniprot_accessions":["Q8IXJ6"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q8IXJ6","entry_name":"SIR2_HUMAN","gene_names":"SIRT2 SIR2L SIR2L2","lipidation":"","provisional_surface_signal":"membrane-only","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12697818, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:16648462, ECO:0000269|PubMed:17726514, ECO:0000269|PubMed:20543840, ECO:0000269|PubMed:23908241, ECO:0000269|PubMed:24177535}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8VDQ8}. Cytoplasm {ECO:0000269|PubMed:12697818, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:16648462, ECO:0000269|PubMed:17726514, ECO:0000269|PubMed:20543840, ECO:0000269|PubMed:23908241, ECO:0000269|PubMed:24681946}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12620231}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17488717, ECO:0000269|PubMed:17726514}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:17726514}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:17488717}. Midbody {ECO:0000269|PubMed:17726514}. Chromosome {ECO:0000269|PubMed:16648462, ECO:0000269|PubMed:23468428}. Perikaryon {ECO:0000250|UniProtKB:Q8VDQ8}. Cell projection {ECO:0000250|UniProtKB:Q8VDQ8}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q8VDQ8}. Myelin membrane {ECO:0000250|UniProtKB:Q8VDQ8}. Note=Localizes in the cytoplasm during most of the cell cycle except in the G2/M transition and during mitosis, where it is localized in association with chromatin and induces deacetylation of histone at 'Lys-16' (H4K16ac) (PubMed:17726514, PubMed:23468428). Colocalizes with KMT5A at mitotic foci (PubMed:23468428). Colocalizes with CDK1 at centrosome during prophase and splindle fibers during metaphase (PubMed:17488717). Colocalizes with Aurora kinase AURKA at centrosome during early prophase and in the centrioles and growing mitotic spindle throughout metaphase (PubMed:17488717). Colocalizes with Aurora kinase AURKB during cytokinesis with the midbody (PubMed:17488717). Colocalizes with microtubules (PubMed:12620231). Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins (By similarity). Shuttles between the cytoplasm and the nucleus through the CRM1 export pathway (PubMed:17726514). Colocalizes with EP300 in the nucleus (PubMed:24177535). Translocates to the nucleus and chromatin upon bacterium Listeria monocytogenes infection in interphase cells (PubMed:23908241). Deacetylates FOXO3 in the cytoplasm (By similarity). Colocalizes with PLP1 in internodal regions, at paranodal axoglial junction and Schmidt-Lanterman incisures of myelin sheath (By similarity). Colocalizes with CDK5R1 in the perikaryon, neurites and growth cone of hippocampal neurons (By similarity). Colocalizes with alpha-tubulin in neuronal growth cone (By similarity). Localizes in the cytoplasm and nucleus of germinal vesicle (GV) stage oocytes (By similarity). Colocalizes with alpha-tubulin on the meiotic spindle as the oocytes enter into metaphase, and also during meiotic anaphase and telophase, especially with the midbody (By similarity). Colocalizes with PARD3 in internodal region of axons (By similarity). Colocalizes with acetylated alpha-tubulin in cell projection processes during primary oligodendrocyte precursor (OLP) differentiation (By similarity). {ECO:0000250|UniProtKB:Q8VDQ8, ECO:0000269|PubMed:12620231, ECO:0000269|PubMed:17488717, ECO:0000269|PubMed:17726514, ECO:0000269|PubMed:23468428, ECO:0000269|PubMed:23908241, ECO:0000269|PubMed:24177535}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:24177535}. Nucleus {ECO:0000269|PubMed:24177535}. Note=Predominantly localized in the cytoplasmic. {ECO:0000269|PubMed:24177535}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:24177535}. Nucleus {ECO:0000269|PubMed:24177535}. Note=Predominantly localized in the cytoplasmic. {ECO:0000269|PubMed:24177535}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000269|PubMed:24177535}. Nucleus {ECO:0000269|PubMed:24177535}. Note=Predominantly localized in the nucleus. {ECO:0000269|PubMed:24177535}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"membrane-only","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":507,"datasource_scores":[{"id":"europepmc","score":0.012158615952232422}],"score":0.0014783194187388072,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":13503,"filename":"MONDO_0005007-associated-targets-page-2.json","sha256":"26a9df77e260244ca3b7d5d09ea58127fca45365ce5ac3dd036ffb2a38df2b0d"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000096088","exclusion_id":"X-ENSG00000096088","identifiers":{"approved_symbol":"PGC","ensembl_gene_id":"ENSG00000096088"},"preferred_label":"PGC","reconciliation":{"canonical_uniprot_accessions":["P20142"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P20142","entry_name":"PEPC_HUMAN","gene_names":"PGC","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"SIGNAL 1..16; /evidence=\"ECO:0000269|PubMed:2515193, ECO:0000269|PubMed:6816595\"","subcellular_location":"SUBCELLULAR LOCATION: Secreted.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":508,"datasource_scores":[{"id":"europepmc","score":0.012158615952232422}],"score":0.0014783194187388072,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":13503,"filename":"MONDO_0005007-associated-targets-page-2.json","sha256":"26a9df77e260244ca3b7d5d09ea58127fca45365ce5ac3dd036ffb2a38df2b0d"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000109670","exclusion_id":"X-ENSG00000109670","identifiers":{"approved_symbol":"FBXW7","ensembl_gene_id":"ENSG00000109670"},"preferred_label":"FBXW7","reconciliation":{"canonical_uniprot_accessions":["Q969H0"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q969H0","entry_name":"FBXW7_HUMAN","gene_names":"FBXW7 FBW7 FBX30 SEL10","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: [Isoform 1]: Nucleus, nucleoplasm {ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:28007894}. Chromosome {ECO:0000269|PubMed:26774286}. Note=Localizes to site of double-strand breaks following phosphorylation by ATM. {ECO:0000269|PubMed:26774286}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:28007894}.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus, nucleolus {ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:28007894}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":509,"datasource_scores":[{"id":"europepmc","score":0.012158615952232422}],"score":0.0014783194187388072,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":13503,"filename":"MONDO_0005007-associated-targets-page-2.json","sha256":"26a9df77e260244ca3b7d5d09ea58127fca45365ce5ac3dd036ffb2a38df2b0d"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000104044","exclusion_id":"X-ENSG00000104044","identifiers":{"approved_symbol":"OCA2","ensembl_gene_id":"ENSG00000104044"},"preferred_label":"OCA2","reconciliation":{"canonical_uniprot_accessions":["Q04671"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q04671","entry_name":"P_HUMAN","gene_names":"OCA2 D15S12 P","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Melanosome membrane {ECO:0000269|PubMed:25513726, ECO:0000269|PubMed:7601462}; Multi-pass membrane protein {ECO:0000269|PubMed:7601462}.","topological_domain":"TOPO_DOM 1..179; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 198..330; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 348..353; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 371..384; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 402..423; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 441..513; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 531..620; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 638..647; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 665..679; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 697..720; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 738..760; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 778..817; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 835..838; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 180..197; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 331..347; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 354..370; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 385..401; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 424..440; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 514..530; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 621..637; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 648..664; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 680..696; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 721..737; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 761..777; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 818..834; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":510,"datasource_scores":[{"id":"europepmc","score":0.012158615952232422}],"score":0.0014783194187388072,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":13503,"filename":"MONDO_0005007-associated-targets-page-2.json","sha256":"26a9df77e260244ca3b7d5d09ea58127fca45365ce5ac3dd036ffb2a38df2b0d"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000104972","identifiers":{"approved_symbol":"LILRB1","ensembl_gene_id":"ENSG00000104972"},"preferred_label":"LILRB1","reconciliation":{"canonical_uniprot_accessions":["Q8NHL6"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000104972","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q8NHL6","entry_name":"LIRB1_HUMAN","gene_names":"LILRB1 ILT2 LIR1 MIR7","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..23; 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Peroxisome {ECO:0000250}. 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Cytoplasm, cytosol {ECO:0000269|PubMed:10585443, ECO:0000269|PubMed:24529379}. Note=Recruited to lysosomal membranes in a RHEB-dependent process in absence of nutrients (PubMed:24529379). 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Nucleus {ECO:0000250|UniProtKB:P70096}. Chromosome, centromere {ECO:0000269|PubMed:14960279, ECO:0000269|PubMed:17485487}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:14960279, ECO:0000269|PubMed:17485487, ECO:0000269|PubMed:23891108}. Note=Associates with the microtubule network at the growing distal tip (the plus-end) of microtubules, probably through interaction with MTUS2/TIP150 and MAPRE1 (By similarity). Association with microtubule plus ends is also mediated by interaction with KIF18B. Centromeric localization requires the presence of BUB1 and SGO2. {ECO:0000250|UniProtKB:P70096, ECO:0000269|PubMed:17485487, ECO:0000269|PubMed:21820309}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":515,"datasource_scores":[{"id":"europepmc","score":0.012158615952232422}],"score":0.0014783194187388072,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":13503,"filename":"MONDO_0005007-associated-targets-page-2.json","sha256":"26a9df77e260244ca3b7d5d09ea58127fca45365ce5ac3dd036ffb2a38df2b0d"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000100146","exclusion_id":"X-ENSG00000100146","identifiers":{"approved_symbol":"SOX10","ensembl_gene_id":"ENSG00000100146"},"preferred_label":"SOX10","reconciliation":{"canonical_uniprot_accessions":["P56693"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P56693","entry_name":"SOX10_HUMAN","gene_names":"SOX10","lipidation":"","provisional_surface_signal":"membrane-only","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12138193}. 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RHO12","lipidation":"LIPID 185; /note=\"(Microbial infection) N6-stearoyl lysine\"; /evidence=\"ECO:0000269|PubMed:30061757\"; LIPID 186; /note=\"(Microbial infection) N6-stearoyl lysine\"; /evidence=\"ECO:0000269|PubMed:30061757\"; LIPID 187; /note=\"(Microbial infection) N6-stearoyl lysine\"; /evidence=\"ECO:0000269|PubMed:30061757\"; LIPID 190; /note=\"S-geranylgeranyl cysteine\"; /evidence=\"ECO:0000250|UniProtKB:P61585\"","provisional_surface_signal":"plasma-membrane-annotation","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow. Cytoplasm, cell cortex {ECO:0000269|PubMed:9635436}. Midbody. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q9QUI0}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9QUI0}. Nucleus {ECO:0000269|PubMed:12551911}. Cytoplasm {ECO:0000269|PubMed:23871831}. Note=Localized to cell-cell contacts in calcium-treated keratinocytes (By similarity). Translocates to the equatorial region before furrow formation in a ECT2-dependent manner. Localizes to the equatorial cell cortex (at the site of the presumptive furrow) in early anaphase in an activated form and in a myosin- and actin-independent manner. Colocalizes with KANK1 at the contractile ring. Colocalizes with DAAM1 and KANK1 around centrosomes. {ECO:0000250|UniProtKB:Q9QUI0}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"plasma-membrane-annotation","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":519,"datasource_scores":[{"id":"europepmc","score":0.012158615952232422}],"score":0.0014783194187388072,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":13503,"filename":"MONDO_0005007-associated-targets-page-2.json","sha256":"26a9df77e260244ca3b7d5d09ea58127fca45365ce5ac3dd036ffb2a38df2b0d"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000138180","exclusion_id":"X-ENSG00000138180","identifiers":{"approved_symbol":"CEP55","ensembl_gene_id":"ENSG00000138180"},"preferred_label":"CEP55","reconciliation":{"canonical_uniprot_accessions":["Q53EZ4"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q53EZ4","entry_name":"CEP55_HUMAN","gene_names":"CEP55 C10orf3 URCC6","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28264986}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:16198290}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:16198290}. Cleavage furrow {ECO:0000269|PubMed:16198290}. Midbody, Midbody ring {ECO:0000269|PubMed:16198290, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:18641129, ECO:0000269|PubMed:21310966, ECO:0000269|PubMed:28264986}. Midbody {ECO:0000269|PubMed:36825683, ECO:0000269|PubMed:41361016}. Note=Present at the centrosomes at interphase. A small portion is associated preferentially with the mother centriole, whereas the majority localizes to the pericentriolar material. During mitosis, loses affinity for the centrosome at the onset of prophase and diffuses throughout the cell. This dissociation from the centrosome is phosphorylation-dependent. May remain localized at the centrosome during mitosis in certain cell types. Appears at the cleavage furrow in late anaphase and in the midbody in cytokinesis. {ECO:0000269|PubMed:16198290}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":520,"datasource_scores":[{"id":"europepmc","score":0.012158615952232422}],"score":0.0014783194187388072,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":13503,"filename":"MONDO_0005007-associated-targets-page-2.json","sha256":"26a9df77e260244ca3b7d5d09ea58127fca45365ce5ac3dd036ffb2a38df2b0d"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000145147","exclusion_id":"X-ENSG00000145147","identifiers":{"approved_symbol":"SLIT2","ensembl_gene_id":"ENSG00000145147"},"preferred_label":"SLIT2","reconciliation":{"canonical_uniprot_accessions":["O94813"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"O94813","entry_name":"SLIT2_HUMAN","gene_names":"SLIT2 SLIL3","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"SIGNAL 1..30; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10102268}. Note=The C-terminal cleavage protein is more diffusible than the larger N-terminal protein that is more tightly cell associated.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":521,"datasource_scores":[{"id":"europepmc","score":0.012158615952232422}],"score":0.0014783194187388072,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":13503,"filename":"MONDO_0005007-associated-targets-page-2.json","sha256":"26a9df77e260244ca3b7d5d09ea58127fca45365ce5ac3dd036ffb2a38df2b0d"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000116670","exclusion_id":"X-ENSG00000116670","identifiers":{"approved_symbol":"MAD2L2","ensembl_gene_id":"ENSG00000116670"},"preferred_label":"MAD2L2","reconciliation":{"canonical_uniprot_accessions":["Q9UI95"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q9UI95","entry_name":"MD2L2_HUMAN","gene_names":"MAD2L2 MAD2B REV7","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11717438, ECO:0000269|PubMed:17541814, ECO:0000269|PubMed:17719540, ECO:0000269|PubMed:19753112}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:19753112, ECO:0000269|PubMed:21063390}. Cytoplasm {ECO:0000269|PubMed:11717438, ECO:0000269|PubMed:17719540}. Chromosome {ECO:0000269|PubMed:29656893}. Note=Recruited to sites of chromosomal double-stranded breaks during G1 and S phase of the cell cycle. {ECO:0000269|PubMed:29656893}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":522,"datasource_scores":[{"id":"europepmc","score":0.012158615952232422}],"score":0.0014783194187388072,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":13503,"filename":"MONDO_0005007-associated-targets-page-2.json","sha256":"26a9df77e260244ca3b7d5d09ea58127fca45365ce5ac3dd036ffb2a38df2b0d"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000178568","identifiers":{"approved_symbol":"ERBB4","ensembl_gene_id":"ENSG00000178568"},"preferred_label":"ERBB4","reconciliation":{"canonical_uniprot_accessions":["Q15303"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000178568","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q15303","entry_name":"ERBB4_HUMAN","gene_names":"ERBB4 HER4","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..25; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10348342, ECO:0000269|PubMed:12807903, ECO:0000269|PubMed:15534001, ECO:0000269|PubMed:16251361, ECO:0000269|PubMed:16778220, ECO:0000269|PubMed:16837552, ECO:0000269|PubMed:17486069, ECO:0000269|PubMed:17638867, ECO:0000269|PubMed:19193720, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:9334263}; Single-pass type I membrane protein {ECO:0000269|PubMed:10348342, ECO:0000269|PubMed:12807903, ECO:0000269|PubMed:15534001, ECO:0000269|PubMed:16251361, ECO:0000269|PubMed:16778220, ECO:0000269|PubMed:16837552, ECO:0000269|PubMed:17486069, ECO:0000269|PubMed:17638867, ECO:0000269|PubMed:19193720, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:9334263}. Note=In response to NRG1 treatment, the activated receptor is internalized.; SUBCELLULAR LOCATION: [ERBB4 intracellular domain]: Nucleus {ECO:0000269|PubMed:17486069}. Mitochondrion {ECO:0000269|PubMed:17486069}. Note=Following proteolytical processing E4ICD (E4ICD1 or E4ICD2 generated from the respective isoforms) is translocated to the nucleus. Significantly more E4ICD2 than E4ICD1 is found in the nucleus. E4ICD2 colocalizes with YAP1 in the nucleus.","topological_domain":"TOPO_DOM 26..651; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 676..1308; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 652..675; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":523,"datasource_scores":[{"id":"europepmc","score":0.012158615952232422}],"score":0.0014783194187388072,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets 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Single-pass type II membrane protein {ECO:0000250|UniProtKB:P05027}. Apical cell membrane {ECO:0000250|UniProtKB:P07340}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P05027}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P14094}. Note=Colocalizes with OBSCN at the intercalated disk and sarcolemma in cardiomyocytes. Localizes in long striations at the level of Z and M lines. {ECO:0000250|UniProtKB:P14094}.","topological_domain":"TOPO_DOM 1..34; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000250|UniProtKB:P05027\"; TOPO_DOM 63..303; /note=\"Extracellular\"; /evidence=\"ECO:0000250|UniProtKB:P05027\"","transmembrane":"TRANSMEM 35..62; /note=\"Helical; Signal-anchor for type II membrane protein\"; /evidence=\"ECO:0000250|UniProtKB:P05027\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":537,"datasource_scores":[{"id":"europepmc","score":0.012158615952232422}],"score":0.0014783194187388072,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":13503,"filename":"MONDO_0005007-associated-targets-page-2.json","sha256":"26a9df77e260244ca3b7d5d09ea58127fca45365ce5ac3dd036ffb2a38df2b0d"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000150630","exclusion_id":"X-ENSG00000150630","identifiers":{"approved_symbol":"VEGFC","ensembl_gene_id":"ENSG00000150630"},"preferred_label":"VEGFC","reconciliation":{"canonical_uniprot_accessions":["P49767"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P49767","entry_name":"VEGFC_HUMAN","gene_names":"VEGFC","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"SIGNAL 1..31; /evidence=\"ECO:0000269|PubMed:15340161, ECO:0000269|PubMed:9233800\"","subcellular_location":"SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:9233800}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":538,"datasource_scores":[{"id":"europepmc","score":0.012158615952232422}],"score":0.0014783194187388072,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":13503,"filename":"MONDO_0005007-associated-targets-page-2.json","sha256":"26a9df77e260244ca3b7d5d09ea58127fca45365ce5ac3dd036ffb2a38df2b0d"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000189057","identifiers":{"approved_symbol":"FAM111B","ensembl_gene_id":"ENSG00000189057"},"preferred_label":"FAM111B","reconciliation":{"canonical_uniprot_accessions":["Q6SJ93"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"localization-unresolved","reasons":["The canonical reviewed UniProt entry has no decisive localization annotation."],"state":"unresolved","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"unresolved","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q6SJ93","entry_name":"F111B_HUMAN","gene_names":"FAM111B CANP","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":539,"datasource_scores":[{"id":"europepmc","score":0.012158615952232422}],"score":0.0014783194187388072,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":13503,"filename":"MONDO_0005007-associated-targets-page-2.json","sha256":"26a9df77e260244ca3b7d5d09ea58127fca45365ce5ac3dd036ffb2a38df2b0d"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000088256","identifiers":{"approved_symbol":"GNA11","ensembl_gene_id":"ENSG00000088256"},"preferred_label":"GNA11","reconciliation":{"canonical_uniprot_accessions":["P29992"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"extracellular-accessibility-unresolved","reasons":["A membrane or cell-surface localization is reported, but extracellular orientation or anchoring is unresolved."],"state":"unresolved","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"unresolved","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P29992","entry_name":"GNA11_HUMAN","gene_names":"GNA11 GA11","lipidation":"LIPID 9; /note=\"S-palmitoyl cysteine\"; /evidence=\"ECO:0000269|PubMed:21044946\"; LIPID 10; /note=\"S-palmitoyl cysteine\"; /evidence=\"ECO:0000269|PubMed:21044946\"","provisional_surface_signal":"plasma-membrane-annotation","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:18703424}; Lipid-anchor {ECO:0000305|PubMed:18703424}. Cytoplasm {ECO:0000269|PubMed:18703424}. Note=In testicular cells, expressed exclusively in the cytoplasm. {ECO:0000269|PubMed:18703424}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"plasma-membrane-annotation","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":540,"datasource_scores":[{"id":"europepmc","score":0.012158615952232422}],"score":0.0014783194187388072,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":13503,"filename":"MONDO_0005007-associated-targets-page-2.json","sha256":"26a9df77e260244ca3b7d5d09ea58127fca45365ce5ac3dd036ffb2a38df2b0d"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000166923","exclusion_id":"X-ENSG00000166923","identifiers":{"approved_symbol":"GREM1","ensembl_gene_id":"ENSG00000166923"},"preferred_label":"GREM1","reconciliation":{"canonical_uniprot_accessions":["O60565"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"O60565","entry_name":"GREM1_HUMAN","gene_names":"GREM1 CKTSF1B1 DAND2 DRM PIG2","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"SIGNAL 1..24; /evidence=\"ECO:0000269|PubMed:15340161\"","subcellular_location":"SUBCELLULAR LOCATION: Secreted {ECO:0000305}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":541,"datasource_scores":[{"id":"europepmc","score":0.012158615952232422}],"score":0.0014783194187388072,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":13503,"filename":"MONDO_0005007-associated-targets-page-2.json","sha256":"26a9df77e260244ca3b7d5d09ea58127fca45365ce5ac3dd036ffb2a38df2b0d"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000093009","exclusion_id":"X-ENSG00000093009","identifiers":{"approved_symbol":"CDC45","ensembl_gene_id":"ENSG00000093009"},"preferred_label":"CDC45","reconciliation":{"canonical_uniprot_accessions":["O75419"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"O75419","entry_name":"CDC45_HUMAN","gene_names":"CDC45 CDC45L CDC45L2 UNQ374/PRO710","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:35585232}. Chromosome {ECO:0000305|PubMed:35585232}. Note=Associates with chromatin. {ECO:0000305|PubMed:35585232}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":542,"datasource_scores":[{"id":"europepmc","score":0.012158615952232422}],"score":0.0014783194187388072,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":13503,"filename":"MONDO_0005007-associated-targets-page-2.json","sha256":"26a9df77e260244ca3b7d5d09ea58127fca45365ce5ac3dd036ffb2a38df2b0d"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000099250","identifiers":{"approved_symbol":"NRP1","ensembl_gene_id":"ENSG00000099250"},"preferred_label":"NRP1","reconciliation":{"canonical_uniprot_accessions":["O14786"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"surface-target","target_id":"T-ENSG00000099250","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"O14786","entry_name":"NRP1_HUMAN","gene_names":"NRP1 NRP VEGF165R","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..21; /evidence=\"ECO:0000269|PubMed:10688880, ECO:0000269|PubMed:9529250\"","subcellular_location":"SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:10688880}.; SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305|PubMed:30623799}; Single-pass type I membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:30623799}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:30623799}.; SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:34742300}. Note=(Microbial infection) Proteolytically cleaved at the cell membrane upon H.pylori infection. {ECO:0000269|PubMed:34742300}.","topological_domain":"TOPO_DOM 22..856; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 880..923; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 857..879; /note=\"Helical\"; /evidence=\"ECO:0000255\""},{"accession":"Q92832","entry_name":"NELL1_HUMAN","gene_names":"NELL1 NRP1","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"SIGNAL 1..21; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21723284}. Nucleus envelope {ECO:0000269|PubMed:21723284}. Secreted {ECO:0000250|UniProtKB:Q62919}. Note=Colocalizes with ATRAID on the nuclear envelope and the perinuclear region.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":543,"datasource_scores":[{"id":"europepmc","score":0.012158615952232422}],"score":0.0014783194187388072,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":13503,"filename":"MONDO_0005007-associated-targets-page-2.json","sha256":"26a9df77e260244ca3b7d5d09ea58127fca45365ce5ac3dd036ffb2a38df2b0d"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000113649","exclusion_id":"X-ENSG00000113649","identifiers":{"approved_symbol":"TCERG1","ensembl_gene_id":"ENSG00000113649"},"preferred_label":"TCERG1","reconciliation":{"canonical_uniprot_accessions":["O14776"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"O14776","entry_name":"TCRG1_HUMAN","gene_names":"TCERG1 CA150 TAF2S","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10908677, ECO:0000269|PubMed:15485897, ECO:0000269|PubMed:9315662}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"no-signal","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":544,"datasource_scores":[{"id":"europepmc","score":0.012158615952232422}],"score":0.0014783194187388072,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":13503,"filename":"MONDO_0005007-associated-targets-page-2.json","sha256":"26a9df77e260244ca3b7d5d09ea58127fca45365ce5ac3dd036ffb2a38df2b0d"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000044115","identifiers":{"approved_symbol":"CTNNA1","ensembl_gene_id":"ENSG00000044115"},"preferred_label":"CTNNA1","reconciliation":{"canonical_uniprot_accessions":["P35221"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"conflicting-surface-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt localization places the canonical protein on the cytoplasmic face or as a peripheral membrane protein."],"state":"unresolved","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"unresolved","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P35221","entry_name":"CTNA1_HUMAN","gene_names":"CTNNA1","lipidation":"","provisional_surface_signal":"plasma-membrane-annotation","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P26231}. Cell junction, adherens junction {ECO:0000269|PubMed:25653389}. Cell membrane {ECO:0000250|UniProtKB:P26231}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000250|UniProtKB:P26231}. Cell junction {ECO:0000269|PubMed:12417594, ECO:0000269|PubMed:16184169}. Cytoplasm {ECO:0000250|UniProtKB:Q9PVF8}. Nucleus {ECO:0000269|PubMed:16184169}. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries. {ECO:0000250|UniProtKB:P26231}.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane {ECO:0000269|PubMed:21708131}; Peripheral membrane protein {ECO:0000269|PubMed:21708131}; Cytoplasmic side {ECO:0000269|PubMed:21708131}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"plasma-membrane-annotation","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":545,"datasource_scores":[{"id":"europepmc","score":0.012158615952232422}],"score":0.0014783194187388072,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":13503,"filename":"MONDO_0005007-associated-targets-page-2.json","sha256":"26a9df77e260244ca3b7d5d09ea58127fca45365ce5ac3dd036ffb2a38df2b0d"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000163220","identifiers":{"approved_symbol":"S100A9","ensembl_gene_id":"ENSG00000163220"},"preferred_label":"S100A9","reconciliation":{"canonical_uniprot_accessions":["P06702"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"conflicting-surface-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt localization places the canonical protein on the cytoplasmic face or as a peripheral membrane protein."],"state":"unresolved","tcsa_overlay_present":true},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"unresolved","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P06702","entry_name":"S10A9_HUMAN","gene_names":"S100A9 CAGB CFAG MRP14","lipidation":"","provisional_surface_signal":"plasma-membrane-annotation","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Secreted. Cytoplasm {ECO:0000269|PubMed:15598812, ECO:0000269|PubMed:8423249}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22489132, ECO:0000269|PubMed:9083090}. Cell membrane {ECO:0000269|PubMed:18786929}; Peripheral membrane protein {ECO:0000305|PubMed:18786929}. Note=Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated from the cytoplasm to the cytoskeleton and the cell membrane (PubMed:18786929). Upon neutrophil activation or endothelial adhesion of monocytes, is secreted via a microtubule-mediated, alternative pathway (PubMed:15598812). {ECO:0000269|PubMed:15598812, ECO:0000269|PubMed:18786929}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"plasma-membrane-annotation","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"associated_target_rank":546,"datasource_scores":[{"id":"europepmc","score":0.012158615952232422}],"score":0.0014783194187388072,"source_date":"2026-09-04","source_id":"open-targets","source_name":"Open Targets Platform","source_snapshot":{"bytes":13503,"filename":"MONDO_0005007-associated-targets-page-2.json","sha256":"26a9df77e260244ca3b7d5d09ea58127fca45365ce5ac3dd036ffb2a38df2b0d"},"source_url":"https://api.platform.opentargets.org/api/v4/graphql"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"protein-coding-gene","entity_id":"E-OT-MONDO_0005007-ENSG00000169218","exclusion_id":"X-ENSG00000169218","identifiers":{"approved_symbol":"RSPO1","ensembl_gene_id":"ENSG00000169218"},"preferred_label":"RSPO1","reconciliation":{"canonical_uniprot_accessions":["Q2MKA7"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":false,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-intracellular-soluble-or-organelle-only","reasons":["Canonical reviewed UniProt localization does not place the protein on the extracellular face of the plasma membrane."],"state":"excluded","tcsa_overlay_present":false},"record_origin":"opentargets-associated-targets","source_type":"disease-association","surface_disposition":"excluded-from-surface-universe","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q2MKA7","entry_name":"RSPO1_HUMAN","gene_names":"RSPO1","lipidation":"","provisional_surface_signal":"no-signal","signal_peptide":"SIGNAL 1..20; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:26764097, ECO:0000269|PubMed:27123103}. Nucleus {ECO:0000250|UniProtKB:Q9Z132}. 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/evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.","topological_domain":"TOPO_DOM 27..274; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 298..323; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 275..297; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"association_score":null,"datasource_scores":[],"favorable_evidence":false,"source_id":"query-expansion-seed"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"seed-symbol","entity_id":"E-SEED-MONDO_0005007-TSPAN8","identifiers":{"approved_symbol":"TSPAN8"},"preferred_label":"TSPAN8","query_expansion_seeds":[{"category":"lineage-and-tumor-antigens","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["P19075"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"query-expansion-seed","source_type":"query-expansion-seed","surface_disposition":"surface-target","target_id":"T-ENSG00000127324","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P19075","entry_name":"TSN8_HUMAN","gene_names":"TSPAN8 TM4SF3","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27180357, ECO:0000269|PubMed:34524408, ECO:0000269|PubMed:37204469, ECO:0000269|PubMed:37835445}; Multi-pass membrane protein.","topological_domain":"TOPO_DOM 1..9; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 34..57; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 73..83; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 110..205; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 231..237; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 10..33; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 58..72; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 84..109; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 206..230; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"association_score":null,"datasource_scores":[],"favorable_evidence":false,"source_id":"query-expansion-seed"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"seed-symbol","entity_id":"E-SEED-MONDO_0005007-TPBG","identifiers":{"approved_symbol":"TPBG"},"preferred_label":"TPBG","query_expansion_seeds":[{"category":"lineage-and-tumor-antigens","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["Q13641"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"query-expansion-seed","source_type":"query-expansion-seed","surface_disposition":"surface-target","target_id":"T-ENSG00000146242","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q13641","entry_name":"TPBG_HUMAN","gene_names":"TPBG 5T4","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..31; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24582434}; Single-pass type I membrane protein {ECO:0000269|PubMed:24582434}.","topological_domain":"TOPO_DOM 32..355; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 377..420; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 356..376; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"association_score":null,"datasource_scores":[],"favorable_evidence":false,"source_id":"query-expansion-seed"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"seed-symbol","entity_id":"E-SEED-MONDO_0005007-L1CAM","identifiers":{"approved_symbol":"L1CAM"},"preferred_label":"L1CAM","query_expansion_seeds":[{"category":"lineage-and-tumor-antigens","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["P32004"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"query-expansion-seed","source_type":"query-expansion-seed","surface_disposition":"surface-target","target_id":"T-ENSG00000198910","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P32004","entry_name":"L1CAM_HUMAN","gene_names":"L1CAM CAML1 MIC5","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..19; /evidence=\"ECO:0000269|PubMed:3136168\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12514225, ECO:0000269|PubMed:20621658, ECO:0000269|PubMed:22973895, ECO:0000269|PubMed:26891472}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q05695}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q05695}. Cell projection, axon {ECO:0000269|PubMed:20621658}. Cell projection, dendrite. Note=Colocalized with SHTN1 in close apposition with actin filaments in filopodia and lamellipodia of axonalne growth cones of hippocampal neurons (By similarity). In neurons, detected predominantly in axons and cell body, weak localization to dendrites (PubMed:20621658). {ECO:0000250|UniProtKB:Q05695, ECO:0000269|PubMed:20621658}.","topological_domain":"TOPO_DOM 20..1120; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 1144..1257; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 1121..1143; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"association_score":null,"datasource_scores":[],"favorable_evidence":false,"source_id":"query-expansion-seed"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"seed-symbol","entity_id":"E-SEED-MONDO_0005007-AXL","identifiers":{"approved_symbol":"AXL"},"preferred_label":"AXL","query_expansion_seeds":[{"category":"signaling-receptors","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["P30530"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"query-expansion-seed","source_type":"query-expansion-seed","surface_disposition":"surface-target","target_id":"T-ENSG00000167601","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P30530","entry_name":"UFO_HUMAN","gene_names":"AXL UFO","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..25; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28076778, ECO:0000269|PubMed:29379210, ECO:0000269|PubMed:7896447}; Single-pass type I membrane protein {ECO:0000269|PubMed:7896447}.","topological_domain":"TOPO_DOM 26..451; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 473..894; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 452..472; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"association_score":null,"datasource_scores":[],"favorable_evidence":false,"source_id":"query-expansion-seed"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"seed-symbol","entity_id":"E-SEED-MONDO_0005007-EPHA2","identifiers":{"approved_symbol":"EPHA2"},"preferred_label":"EPHA2","query_expansion_seeds":[{"category":"signaling-receptors","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["P29317"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"query-expansion-seed","source_type":"query-expansion-seed","surface_disposition":"surface-target","target_id":"T-ENSG00000142627","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P29317","entry_name":"EPHA2_HUMAN","gene_names":"EPHA2 ECK","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..23; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18794797, ECO:0000269|PubMed:19573808, ECO:0000269|PubMed:20223987, ECO:0000269|PubMed:20861311, ECO:0000269|PubMed:34067457}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, ruffle membrane {ECO:0000269|PubMed:19573808}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:19573808}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, focal adhesion {ECO:0000269|PubMed:10655584}. Note=Present at regions of cell-cell contacts but also at the leading edge of migrating cells (PubMed:19573808, PubMed:20861311). Relocates from the plasma membrane to the cytoplasmic and perinuclear regions in cancer cells (PubMed:18794797). {ECO:0000269|PubMed:18794797, ECO:0000269|PubMed:19573808, ECO:0000269|PubMed:20861311, ECO:0000269|PubMed:26158630}.","topological_domain":"TOPO_DOM 24..537; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 559..976; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 538..558; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"association_score":null,"datasource_scores":[],"favorable_evidence":false,"source_id":"query-expansion-seed"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"seed-symbol","entity_id":"E-SEED-MONDO_0005007-EPHB2","identifiers":{"approved_symbol":"EPHB2"},"preferred_label":"EPHB2","query_expansion_seeds":[{"category":"signaling-receptors","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["P29323"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"query-expansion-seed","source_type":"query-expansion-seed","surface_disposition":"surface-target","target_id":"T-ENSG00000133216","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P29323","entry_name":"EPHB2_HUMAN","gene_names":"EPHB2 DRT EPHT3 EPTH3 ERK HEK5 TYRO5","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..18; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}.; SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:34742300}. Note=(Microbial infection) Proteolytically cleaved at the cell membrane upon H.pylori infection. {ECO:0000269|PubMed:34742300}.","topological_domain":"TOPO_DOM 19..543; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 565..1055; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 544..564; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"association_score":null,"datasource_scores":[],"favorable_evidence":false,"source_id":"query-expansion-seed"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"seed-symbol","entity_id":"E-SEED-MONDO_0005007-EPHB4","identifiers":{"approved_symbol":"EPHB4"},"preferred_label":"EPHB4","query_expansion_seeds":[{"category":"signaling-receptors","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["P54760"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"query-expansion-seed","source_type":"query-expansion-seed","surface_disposition":"surface-target","target_id":"T-ENSG00000196411","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P54760","entry_name":"EPHB4_HUMAN","gene_names":"EPHB4 HTK MYK1 TYRO11","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..15; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28687708, ECO:0000269|PubMed:8188704}; Single-pass type I membrane protein {ECO:0000269|PubMed:8188704}.","topological_domain":"TOPO_DOM 16..539; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 561..987; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 540..560; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"association_score":null,"datasource_scores":[],"favorable_evidence":false,"source_id":"query-expansion-seed"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"seed-symbol","entity_id":"E-SEED-MONDO_0005007-MST1R","identifiers":{"approved_symbol":"MST1R"},"preferred_label":"MST1R","query_expansion_seeds":[{"category":"signaling-receptors","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["Q04912"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"query-expansion-seed","source_type":"query-expansion-seed","surface_disposition":"surface-target","target_id":"T-ENSG00000164078","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q04912","entry_name":"RON_HUMAN","gene_names":"MST1R PTK8 RON","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..24; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.","topological_domain":"TOPO_DOM 25..957; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 979..1400; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 958..978; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"association_score":null,"datasource_scores":[],"favorable_evidence":false,"source_id":"query-expansion-seed"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"seed-symbol","entity_id":"E-SEED-MONDO_0005007-PTK7","identifiers":{"approved_symbol":"PTK7"},"preferred_label":"PTK7","query_expansion_seeds":[{"category":"signaling-receptors","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["Q13308"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"query-expansion-seed","source_type":"query-expansion-seed","surface_disposition":"surface-target","target_id":"T-ENSG00000112655","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q13308","entry_name":"PTK7_HUMAN","gene_names":"PTK7 CCK4","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..30; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20837484}; Single-pass type I membrane protein {ECO:0000255}. Cell junction {ECO:0000269|PubMed:20837484}. Note=Colocalizes with MMP14 at cell junctions. Also localizes at the leading edge of migrating cells. {ECO:0000269|PubMed:20837484}.","topological_domain":"TOPO_DOM 31..704; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 726..1070; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 705..725; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"association_score":null,"datasource_scores":[],"favorable_evidence":false,"source_id":"query-expansion-seed"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"seed-symbol","entity_id":"E-SEED-MONDO_0005007-DDR1","identifiers":{"approved_symbol":"DDR1"},"preferred_label":"DDR1","query_expansion_seeds":[{"category":"signaling-receptors","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["Q08345"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"query-expansion-seed","source_type":"query-expansion-seed","surface_disposition":"surface-target","target_id":"T-ENSG00000204580","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q08345","entry_name":"DDR1_HUMAN","gene_names":"DDR1 CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKE","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..18; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane; Single-pass type I membrane protein.","topological_domain":"TOPO_DOM 21..417; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 439..913; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 418..438; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"association_score":null,"datasource_scores":[],"favorable_evidence":false,"source_id":"query-expansion-seed"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"seed-symbol","entity_id":"E-SEED-MONDO_0005007-ITGB6","identifiers":{"approved_symbol":"ITGB6"},"preferred_label":"ITGB6","query_expansion_seeds":[{"category":"adhesion-invasion-and-ectoenzymes","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["P18564"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"query-expansion-seed","source_type":"query-expansion-seed","surface_disposition":"surface-target","target_id":"T-ENSG00000115221","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P18564","entry_name":"ITB6_HUMAN","gene_names":"ITGB6","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..21; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17545607}; Single-pass type I membrane protein {ECO:0000305}. Cell junction, focal adhesion {ECO:0000269|PubMed:17158881}.","topological_domain":"TOPO_DOM 22..709; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 731..788; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 710..730; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"association_score":null,"datasource_scores":[],"favorable_evidence":false,"source_id":"query-expansion-seed"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"seed-symbol","entity_id":"E-SEED-MONDO_0005007-PLAUR","identifiers":{"approved_symbol":"PLAUR"},"preferred_label":"PLAUR","query_expansion_seeds":[{"category":"adhesion-invasion-and-ectoenzymes","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["Q03405"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt records an integral or GPI-anchored membrane form."],"state":"retained","tcsa_overlay_present":true},"record_origin":"query-expansion-seed","source_type":"query-expansion-seed","surface_disposition":"surface-target","target_id":"T-ENSG00000011422","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q03405","entry_name":"UPAR_HUMAN","gene_names":"PLAUR MO3 UPAR","lipidation":"LIPID 305; /note=\"GPI-anchor amidated glycine\"; /evidence=\"ECO:0000255\"","provisional_surface_signal":"plasma-membrane-annotation","signal_peptide":"SIGNAL 1..22; /evidence=\"ECO:0000269|PubMed:1689240\"","subcellular_location":"SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:12376466}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:28849762}. Cell projection, invadopodium membrane {ECO:0000269|PubMed:12376466}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:28849762}. Note=Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner. {ECO:0000269|PubMed:12376466}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000250|UniProtKB:P49616}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"plasma-membrane-annotation","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"association_score":null,"datasource_scores":[],"favorable_evidence":false,"source_id":"query-expansion-seed"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"seed-symbol","entity_id":"E-SEED-MONDO_0005007-MMP14","identifiers":{"approved_symbol":"MMP14"},"preferred_label":"MMP14","query_expansion_seeds":[{"category":"adhesion-invasion-and-ectoenzymes","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["P50281"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"query-expansion-seed","source_type":"query-expansion-seed","surface_disposition":"surface-target","target_id":"T-ENSG00000157227","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P50281","entry_name":"MMP14_HUMAN","gene_names":"MMP14","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..20; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8015608}; Single-pass type I membrane protein {ECO:0000305}. Melanosome {ECO:0000269|PubMed:17081065}. Cytoplasm {ECO:0000269|PubMed:22065321}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Forms a complex with BST2 and localizes to the cytoplasm (PubMed:17081065). {ECO:0000269|PubMed:17081065}.","topological_domain":"TOPO_DOM 112..541; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 563..582; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 542..562; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"association_score":null,"datasource_scores":[],"favorable_evidence":false,"source_id":"query-expansion-seed"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"seed-symbol","entity_id":"E-SEED-MONDO_0005007-ADAM10","identifiers":{"approved_symbol":"ADAM10"},"preferred_label":"ADAM10","query_expansion_seeds":[{"category":"adhesion-invasion-and-ectoenzymes","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["O14672"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"query-expansion-seed","source_type":"query-expansion-seed","surface_disposition":"surface-target","target_id":"T-ENSG00000137845","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"O14672","entry_name":"ADA10_HUMAN","gene_names":"ADAM10 KUZ MADM","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..19; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20624979, ECO:0000269|PubMed:23676497, ECO:0000269|PubMed:24990881, ECO:0000269|PubMed:26686862, ECO:0000269|PubMed:29430990, ECO:0000269|PubMed:30463011, ECO:0000269|PubMed:33731436}; Single-pass type I membrane protein {ECO:0000305}. Golgi apparatus membrane {ECO:0000269|PubMed:12475894}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:12475894}. Cell projection, axon {ECO:0000250|UniProtKB:O35598}. Cell projection, dendrite {ECO:0000250|UniProtKB:O35598}. Cell junction, adherens junction {ECO:0000269|PubMed:30463011}. Cytoplasm {ECO:0000269|PubMed:30463011}. Note=Is localized in the plasma membrane but is also expressed in the Golgi apparatus and in clathrin-coated vesicles derived likely from the Golgi (PubMed:12475894). During long term depression, it is recruited to the cell membrane by DLG1 (PubMed:23676497). The immature form is mainly located near cytoplasmic fibrillar structures, while the mature form is predominantly located at zonula adherens and the cell membrane (PubMed:30463011). The localization and clustering of mature ADAM10 to zonula adherens is regulated by AFDN, TSPAN33, PLEKHA7 and PDZD11 (PubMed:30463011). {ECO:0000269|PubMed:12475894, ECO:0000269|PubMed:23676497, ECO:0000269|PubMed:30463011}.","topological_domain":"TOPO_DOM 20..672; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 694..748; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 673..693; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"association_score":null,"datasource_scores":[],"favorable_evidence":false,"source_id":"query-expansion-seed"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"seed-symbol","entity_id":"E-SEED-MONDO_0005007-ADAM17","identifiers":{"approved_symbol":"ADAM17"},"preferred_label":"ADAM17","query_expansion_seeds":[{"category":"adhesion-invasion-and-ectoenzymes","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["P78536"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"query-expansion-seed","source_type":"query-expansion-seed","surface_disposition":"surface-target","target_id":"T-ENSG00000151694","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P78536","entry_name":"ADA17_HUMAN","gene_names":"ADAM17 CSVP TACE","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..17; /evidence=\"ECO:0000250|UniProtKB:Q9Z1K9\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:36078095}; Single-pass type I membrane protein.","topological_domain":"TOPO_DOM 215..671; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 693..824; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 672..692; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"association_score":null,"datasource_scores":[],"favorable_evidence":false,"source_id":"query-expansion-seed"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"seed-symbol","entity_id":"E-SEED-MONDO_0005007-ENPP1","identifiers":{"approved_symbol":"ENPP1"},"preferred_label":"ENPP1","query_expansion_seeds":[{"category":"adhesion-invasion-and-ectoenzymes","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["P22413"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"query-expansion-seed","source_type":"query-expansion-seed","surface_disposition":"surface-target","target_id":"T-ENSG00000197594","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P22413","entry_name":"ENPP1_HUMAN","gene_names":"ENPP1 M6S1 NPPS PC1 PDNP1","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: [Ectonucleotide pyrophosphatase/phosphodiesterase family member 1]: Cell membrane {ECO:0000269|PubMed:15072822, ECO:0000269|PubMed:27467858, ECO:0000269|PubMed:8001561}; Single-pass type II membrane protein. Basolateral cell membrane {ECO:0000269|PubMed:11598187}; Single-pass type II membrane protein. Note=Targeted to the basolateral membrane in polarized epithelial cells and in hepatocytes, and to matrix vesicles in osteoblasts (PubMed:11598187). In bile duct cells and cancer cells, located to the apical cytoplasmic side (PubMed:11598187). {ECO:0000269|PubMed:11598187}.; SUBCELLULAR LOCATION: [Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form]: Secreted {ECO:0000250|UniProtKB:P06802}. Note=Secreted following proteolytic cleavage. {ECO:0000250|UniProtKB:P06802}.","topological_domain":"TOPO_DOM 1..76; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 98..925; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 77..97; /note=\"Helical; Signal-anchor for type II membrane protein\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"association_score":null,"datasource_scores":[],"favorable_evidence":false,"source_id":"query-expansion-seed"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"seed-symbol","entity_id":"E-SEED-MONDO_0005007-PDCD1LG2","identifiers":{"approved_symbol":"PDCD1LG2"},"preferred_label":"PDCD1LG2","query_expansion_seeds":[{"category":"tumor-immune-interface","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["Q9BQ51"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"query-expansion-seed","source_type":"query-expansion-seed","surface_disposition":"surface-target","target_id":"T-ENSG00000197646","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q9BQ51","entry_name":"PD1L2_HUMAN","gene_names":"PDCD1LG2 B7DC CD273 PDCD1L2 PDL2","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..19; 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A soluble form has also been detected. {ECO:0000255, ECO:0000269|PubMed:12818165, ECO:0000269|PubMed:15878339, ECO:0000269|PubMed:16782226}.","topological_domain":"TOPO_DOM 25..259; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 281..282; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 260..280; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"association_score":null,"datasource_scores":[],"favorable_evidence":false,"source_id":"query-expansion-seed"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"seed-symbol","entity_id":"E-SEED-MONDO_0005007-CD200","identifiers":{"approved_symbol":"CD200"},"preferred_label":"CD200","query_expansion_seeds":[{"category":"tumor-immune-interface","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["P41217"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"query-expansion-seed","source_type":"query-expansion-seed","surface_disposition":"surface-target","target_id":"T-ENSG00000091972","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P41217","entry_name":"OX2G_HUMAN","gene_names":"CD200 MOX1 MOX2 My033","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..30; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.","topological_domain":"TOPO_DOM 31..232; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 260..278; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 233..259; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"association_score":null,"datasource_scores":[],"favorable_evidence":false,"source_id":"query-expansion-seed"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"seed-symbol","entity_id":"E-SEED-MONDO_0005007-HLA-E","identifiers":{"approved_symbol":"HLA-E"},"preferred_label":"HLA-E","query_expansion_seeds":[{"category":"tumor-immune-interface","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["P13747"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"query-expansion-seed","source_type":"query-expansion-seed","surface_disposition":"surface-target","target_id":"T-ENSG00000204592","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P13747","entry_name":"HLAE_HUMAN","gene_names":"HLA-E HLA-6.2 HLAE","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..21; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17179229, ECO:0000269|PubMed:37264229, ECO:0000269|PubMed:9427624}; Single-pass type I membrane protein. 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Colocalized with DPP4 at invadopodia and lamellipodia membranes of migratory activated endothelial cells in collagenous matrix. Colocalized with DPP4 on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma. Anchored and enriched preferentially by integrin alpha-3/beta-1 at invadopodia, plasma membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner. Localized at plasma and ruffle membranes in a collagen-independent manner. Colocalized with PLAUR preferentially at the cell surface of invadopodia membranes in a cytoskeleton-, integrin- and vitronectin-dependent manner. Concentrated at invadopodia membranes, specialized protrusions of the ventral plasma membrane in a fibrobectin-dependent manner. 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Note=Autophosphorylation promotes ubiquitination and endocytosis.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:8248162}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted.; SUBCELLULAR LOCATION: [Isoform 4]: Secreted.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 6]: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 7]: Cytoplasm {ECO:0000305}.","topological_domain":"TOPO_DOM 27..758; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 781..1338; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 759..780; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"association_score":null,"datasource_scores":[],"favorable_evidence":false,"source_id":"query-expansion-seed"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"seed-symbol","entity_id":"E-SEED-MONDO_0005007-ENG","identifiers":{"approved_symbol":"ENG"},"preferred_label":"ENG","query_expansion_seeds":[{"category":"stroma-and-vasculature","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["P17813"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"query-expansion-seed","source_type":"query-expansion-seed","surface_disposition":"surface-target","target_id":"T-ENSG00000106991","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P17813","entry_name":"EGLN_HUMAN","gene_names":"ENG END","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..25; /evidence=\"ECO:0000269|PubMed:1692830\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10545596, ECO:0000269|PubMed:1326540, ECO:0000269|PubMed:1692830, ECO:0000269|PubMed:17540773, ECO:0000269|PubMed:8370410}; Single-pass type I membrane protein {ECO:0000305|PubMed:1692830, ECO:0000305|PubMed:8370410}.","topological_domain":"TOPO_DOM 26..586; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 612..658; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 587..611; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"association_score":null,"datasource_scores":[],"favorable_evidence":false,"source_id":"query-expansion-seed"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"seed-symbol","entity_id":"E-SEED-MONDO_0005007-CD248","identifiers":{"approved_symbol":"CD248"},"preferred_label":"CD248","query_expansion_seeds":[{"category":"stroma-and-vasculature","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["Q9HCU0"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"query-expansion-seed","source_type":"query-expansion-seed","surface_disposition":"surface-target","target_id":"T-ENSG00000174807","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q9HCU0","entry_name":"CD248_HUMAN","gene_names":"CD248 CD164L1 TEM1","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..17; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.","topological_domain":"TOPO_DOM 18..687; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 709..757; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 688..708; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"association_score":null,"datasource_scores":[],"favorable_evidence":false,"source_id":"query-expansion-seed"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"seed-symbol","entity_id":"E-SEED-MONDO_0005007-ANTXR1","identifiers":{"approved_symbol":"ANTXR1"},"preferred_label":"ANTXR1","query_expansion_seeds":[{"category":"stroma-and-vasculature","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["Q9H6X2"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"query-expansion-seed","source_type":"query-expansion-seed","surface_disposition":"surface-target","target_id":"T-ENSG00000169604","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q9H6X2","entry_name":"ANTR1_HUMAN","gene_names":"ANTXR1 ATR TEM8","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..32; 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Cell projection, lamellipodium membrane {ECO:0000269|PubMed:16762926}; Single-pass type I membrane protein {ECO:0000269|PubMed:16762926}. Cell projection, filopodium membrane {ECO:0000269|PubMed:16762926}; Single-pass type I membrane protein {ECO:0000269|PubMed:16762926}. Note=At the membrane of lamellipodia and at the tip of actin-enriched filopodia (PubMed:16762926). Colocalizes with actin at the base of lamellipodia (PubMed:16762926). {ECO:0000269|PubMed:16762926}.","topological_domain":"TOPO_DOM 33..321; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 343..564; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 322..342; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"association_score":null,"datasource_scores":[],"favorable_evidence":false,"source_id":"query-expansion-seed"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"seed-symbol","entity_id":"E-SEED-MONDO_0005007-ANTXR2","identifiers":{"approved_symbol":"ANTXR2"},"preferred_label":"ANTXR2","query_expansion_seeds":[{"category":"stroma-and-vasculature","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["P58335"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"query-expansion-seed","source_type":"query-expansion-seed","surface_disposition":"surface-target","target_id":"T-ENSG00000163297","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P58335","entry_name":"ANTR2_HUMAN","gene_names":"ANTXR2 CMG2","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..33; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:12700348}; Single-pass type I membrane protein {ECO:0000255}. Note=Expressed at the cell surface. {ECO:0000269|PubMed:12700348}.; SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11683410}; Single-pass type I membrane protein {ECO:0000255}. Note=Expressed predominantly within the endoplasmic reticulum and not at the plasma membrane. {ECO:0000269|PubMed:11683410}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305}.","topological_domain":"TOPO_DOM 34..318; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 342..489; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 319..341; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"association_score":null,"datasource_scores":[],"favorable_evidence":false,"source_id":"query-expansion-seed"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"seed-symbol","entity_id":"E-SEED-MONDO_0005007-DLL4","identifiers":{"approved_symbol":"DLL4"},"preferred_label":"DLL4","query_expansion_seeds":[{"category":"stroma-and-vasculature","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["Q9NR61"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"query-expansion-seed","source_type":"query-expansion-seed","surface_disposition":"surface-target","target_id":"T-ENSG00000128917","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q9NR61","entry_name":"DLL4_HUMAN","gene_names":"DLL4 UNQ1895/PRO4341","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..26; /evidence=\"ECO:0000269|PubMed:15340161\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.","topological_domain":"TOPO_DOM 27..529; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 551..685; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 530..550; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"association_score":null,"datasource_scores":[],"favorable_evidence":false,"source_id":"query-expansion-seed"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"seed-symbol","entity_id":"E-SEED-MONDO_0005007-SLC34A2","identifiers":{"approved_symbol":"SLC34A2"},"preferred_label":"SLC34A2","query_expansion_seeds":[{"category":"context-dependent","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["O95436"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"query-expansion-seed","source_type":"query-expansion-seed","surface_disposition":"surface-target","target_id":"T-ENSG00000157765","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"O95436","entry_name":"NPT2B_HUMAN","gene_names":"SLC34A2","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q9DBP0}; Multi-pass membrane protein {ECO:0000255}. Note=Localized at the brush border membranes of enterocytes. {ECO:0000250|UniProtKB:Q9DBP0}.","topological_domain":"TOPO_DOM 1..100; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 122..135; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 157..212; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 234..362; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 384..407; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 429..485; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 507..525; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 547..552; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 574..689; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 101..121; /note=\"Helical; Name=M1\"; /evidence=\"ECO:0000255\"; TRANSMEM 136..156; /note=\"Helical; Name=M2\"; /evidence=\"ECO:0000255\"; TRANSMEM 213..233; /note=\"Helical; Name=M3\"; /evidence=\"ECO:0000255\"; TRANSMEM 363..383; /note=\"Helical; Name=M4\"; /evidence=\"ECO:0000255\"; TRANSMEM 408..428; /note=\"Helical; Name=M5\"; /evidence=\"ECO:0000255\"; TRANSMEM 486..506; /note=\"Helical; Name=M6\"; /evidence=\"ECO:0000255\"; TRANSMEM 526..546; /note=\"Helical; Name=M7\"; /evidence=\"ECO:0000255\"; TRANSMEM 553..573; /note=\"Helical; Name=M8\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"association_score":null,"datasource_scores":[],"favorable_evidence":false,"source_id":"query-expansion-seed"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"seed-symbol","entity_id":"E-SEED-MONDO_0005007-CA9","identifiers":{"approved_symbol":"CA9"},"preferred_label":"CA9","query_expansion_seeds":[{"category":"context-dependent","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["Q16790"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"query-expansion-seed","source_type":"query-expansion-seed","surface_disposition":"surface-target","target_id":"T-ENSG00000107159","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q16790","entry_name":"CAH9_HUMAN","gene_names":"CA9 G250 MN","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..37; /evidence=\"ECO:0000269|PubMed:15340161\"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8486430}. Nucleus, nucleolus {ECO:0000269|PubMed:8486430}. Cell membrane {ECO:0000269|PubMed:8486430}; Single-pass type I membrane protein {ECO:0000269|PubMed:8486430}. Cell projection, microvillus membrane {ECO:0000269|PubMed:8486430}; Single-pass type I membrane protein {ECO:0000269|PubMed:8486430}. Note=Found on the surface microvilli and in the nucleus, particularly in nucleolus.","topological_domain":"TOPO_DOM 38..414; /note=\"Extracellular\"; TOPO_DOM 436..459; /note=\"Cytoplasmic\"","transmembrane":"TRANSMEM 415..435; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"association_score":null,"datasource_scores":[],"favorable_evidence":false,"source_id":"query-expansion-seed"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"seed-symbol","entity_id":"E-SEED-MONDO_0005007-CLDN2","identifiers":{"approved_symbol":"CLDN2"},"preferred_label":"CLDN2","query_expansion_seeds":[{"category":"context-dependent","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["P57739"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"query-expansion-seed","source_type":"query-expansion-seed","surface_disposition":"surface-target","target_id":"T-ENSG00000165376","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P57739","entry_name":"CLD2_HUMAN","gene_names":"CLDN2 PSEC0059 SP82 UNQ705/PRO1356","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000269|PubMed:20460438}. Cell membrane {ECO:0000250|UniProtKB:O88552}; Multi-pass membrane protein {ECO:0000255}.","topological_domain":"TOPO_DOM 1..7; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 29..81; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 103..116; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 138..162; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 184..230; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 8..28; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 82..102; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 117..137; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 163..183; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"association_score":null,"datasource_scores":[],"favorable_evidence":false,"source_id":"query-expansion-seed"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"seed-symbol","entity_id":"E-SEED-MONDO_0005007-CLDN4","identifiers":{"approved_symbol":"CLDN4"},"preferred_label":"CLDN4","query_expansion_seeds":[{"category":"context-dependent","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["O14493"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"query-expansion-seed","source_type":"query-expansion-seed","surface_disposition":"surface-target","target_id":"T-ENSG00000189143","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"O14493","entry_name":"CLD4_HUMAN","gene_names":"CLDN4 CPER CPETR1 WBSCR8","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000269|PubMed:30734065}. Cell membrane {ECO:0000269|PubMed:20375010}; Multi-pass membrane protein {ECO:0000255}.","topological_domain":"TOPO_DOM 1..7; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 29..81; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 103..117; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 139..160; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 182..209; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 8..28; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 82..102; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 118..138; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 161..181; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"association_score":null,"datasource_scores":[],"favorable_evidence":false,"source_id":"query-expansion-seed"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"seed-symbol","entity_id":"E-SEED-MONDO_0005007-FOLR1","identifiers":{"approved_symbol":"FOLR1"},"preferred_label":"FOLR1","query_expansion_seeds":[{"category":"context-dependent","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["P15328"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt records an integral or GPI-anchored membrane form."],"state":"retained","tcsa_overlay_present":true},"record_origin":"query-expansion-seed","source_type":"query-expansion-seed","surface_disposition":"surface-target","target_id":"T-ENSG00000110195","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P15328","entry_name":"FOLR1_HUMAN","gene_names":"FOLR1 FOLR","lipidation":"LIPID 234; /note=\"GPI-anchor amidated serine\"; /evidence=\"ECO:0000269|PubMed:17566972, ECO:0000269|PubMed:7578066\"","provisional_surface_signal":"plasma-membrane-annotation","signal_peptide":"SIGNAL 1..24; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:2527252, ECO:0000269|PubMed:8033114, ECO:0000269|PubMed:8567728}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:17566972, ECO:0000269|PubMed:7578066}. Apical cell membrane {ECO:0000269|PubMed:10787414}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:17566972, ECO:0000269|PubMed:7578066}. Basolateral cell membrane {ECO:0000269|PubMed:10787414}; Lipid-anchor, GPI-like-anchor {ECO:0000269|PubMed:17566972, ECO:0000269|PubMed:7578066}. Secreted {ECO:0000305|PubMed:3476960}. Cytoplasmic vesicle {ECO:0000269|PubMed:8567728}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:8567728}. Endosome {ECO:0000269|PubMed:8567728}. Note=Endocytosed into cytoplasmic vesicles and then recycled to the cell membrane. {ECO:0000269|PubMed:8567728}.","topological_domain":"","transmembrane":""}],"provisional_surface_signal":"plasma-membrane-annotation","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"association_score":null,"datasource_scores":[],"favorable_evidence":false,"source_id":"query-expansion-seed"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"seed-symbol","entity_id":"E-SEED-MONDO_0005007-NECTIN4","identifiers":{"approved_symbol":"NECTIN4"},"preferred_label":"NECTIN4","query_expansion_seeds":[{"category":"context-dependent","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["Q96NY8"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"reviewed-extracellular-plasma-membrane","reasons":["Reviewed UniProt topology places an extracellular domain on a plasma-membrane protein."],"state":"retained","tcsa_overlay_present":false},"record_origin":"query-expansion-seed","source_type":"query-expansion-seed","surface_disposition":"surface-target","target_id":"T-NECTIN4","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"Q96NY8","entry_name":"NECT4_HUMAN","gene_names":"NECTIN4 LNIR PRR4 PVRL4","lipidation":"","provisional_surface_signal":"extracellular-topology","signal_peptide":"SIGNAL 1..31; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell junction, adherens junction {ECO:0000269|PubMed:11544254}. Note=Colocalizes with AFDN at cadherin-based adherens junctions (PubMed:11544254).; SUBCELLULAR LOCATION: [Processed poliovirus receptor-related protein 4]: Secreted {ECO:0000269|PubMed:15784625}. Note=The secreted form is found in breast tumor patients (PubMed:15784625).","topological_domain":"TOPO_DOM 32..349; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 371..510; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 350..370; /note=\"Helical\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"association_score":null,"datasource_scores":[],"favorable_evidence":false,"source_id":"query-expansion-seed"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous adenocarcinoma"},"entity_class":"seed-symbol","entity_id":"E-SEED-MONDO_0005007-SSTR2","identifiers":{"approved_symbol":"SSTR2"},"preferred_label":"SSTR2","query_expansion_seeds":[{"category":"context-dependent","favorable_evidence":false,"source_snapshot":{"bytes":1567,"filename":"query-seeds.json","sha256":"70d7319240f2a671a2ecb3e23bebe781e7efc0b593baf18cf61bed36bb192121"},"source_type":"query-expansion-seed"}],"reconciliation":{"canonical_uniprot_accessions":["P30874"],"policy_id":"surface-reconciliation-and-prioritization/v0.2","query_seed_present":true,"query_seed_used_as_favorable_evidence":false,"reason_code":"positive-surfaceome-evidence","reasons":["TCSA reports global GESP membership.","Reviewed UniProt topology includes an extracellular domain."],"state":"retained","tcsa_overlay_present":true},"record_origin":"query-expansion-seed","source_type":"query-expansion-seed","surface_disposition":"surface-target","target_id":"T-ENSG00000180616","uniprot_surface_fields":{"interpretation":"provisional retrieval signal for G4 reconciliation","matched_entries":[{"accession":"P30874","entry_name":"SSR2_HUMAN","gene_names":"SSTR2","lipidation":"LIPID 328; /note=\"S-palmitoyl cysteine\"; /evidence=\"ECO:0000255\"","provisional_surface_signal":"extracellular-topology","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Located mainly at the cell surface under basal conditions. Agonist stimulation results in internalization to the cytoplasm.","topological_domain":"TOPO_DOM 1..43; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 68..78; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 104..118; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 139..161; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 182..207; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 230..253; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 279..288; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 304..369; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 44..67; /note=\"Helical; Name=1\"; /evidence=\"ECO:0000255\"; TRANSMEM 79..103; /note=\"Helical; Name=2\"; /evidence=\"ECO:0000255\"; TRANSMEM 119..138; /note=\"Helical; Name=3\"; /evidence=\"ECO:0000255\"; TRANSMEM 162..181; /note=\"Helical; Name=4\"; /evidence=\"ECO:0000255\"; TRANSMEM 208..229; /note=\"Helical; Name=5\"; /evidence=\"ECO:0000255\"; TRANSMEM 254..278; /note=\"Helical; Name=6\"; /evidence=\"ECO:0000255\"; TRANSMEM 289..303; /note=\"Helical; Name=7\"; /evidence=\"ECO:0000255\""}],"provisional_surface_signal":"extracellular-topology","source_id":"uniprot","source_name":"UniProt","source_snapshot":{"bytes":10393994,"filename":"human-reviewed-surface-fields.tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d"}}},{"aliases":[],"association":{"association_score":null,"datasource_scores":[],"favorable_evidence":false,"source_id":"query-expansion-seed"},"disease_context":{"disease_id":"MONDO_0005007","disease_name":"colon mucinous 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