{"atlas_id":"pmmr-mucinous-colon","records":[{"atlas_id":"pmmr-mucinous-colon","campaign_id":"8tcg-itgav-itgb6-geometry-recovery","claim_ceiling":"computational-design-hypothesis","control_calibration_status":"passed","controls":[{"aggregate_metrics":{"ipsae_min_median":0.579046,"target_contact_recall_median":0.954545},"candidate_id":"control-positive-8tcg-chain-c","candidate_manifest":{"bytes":20132,"root":"artifact-root","sha256":"f41b54c0de31a29eb328db414573506b2e16863250b8f7114784316acc449dc6"},"claim_ceiling":"computational-design-hypothesis","class":"deposited-positive","cofold_observations":[{"artifacts":[{"bytes":463135,"role":"predicted-complex","sha256":"b80b13861b57973d3252e42655573f5fca7d7751f9e9d0c867da6e729b472c22"},{"bytes":7936857,"role":"pae","sha256":"b82de3c8de614e4c0d3817f38b0beb2e3e8639069abdbbebfa47504623fcd90b"},{"bytes":3252,"role":"metric-source","sha256":"83e3f52a3c85263a4570d4272daec042ae094285350cb5659edcfc0b4f6b87cd"},{"bytes":474913,"role":"design-pose","sha256":"d888b4278a008d8c8cca71be0918cc471de348990ee011984dcf466aaa64cd52"}],"chain_mapping":{"binder":"A","target":"C"},"environment_identity":"fal-boltz-v1:GPU-H100:1:python-3.12:boltz-2.2.1:torch-2.14.0+cu130","input_chain_mapping":{"A":"C","B":"B","C":"A"},"metrics":{"clash_count":0,"contact_count":57,"hotspot_recovery":1.0,"interface_pae":5.811457,"interface_plddt":84.262093,"ipsae_binder_to_target":0.782668,"ipsae_min":0.579046,"ipsae_target_to_binder":0.579046,"iptm":0.959294,"mapping_status":"ok","sc_dockq":0.7463,"site_contact_iou":0.75,"target_alignment_rmsd":1.9594,"target_contact_precision":0.777778,"target_contact_recall":0.954545},"model_revision":"boltz-2.2.1+cb04aeccdd480fd4db707f0bbafde538397fa2ac","package_version":"2.2.1","phase":"screen","predictor":"boltz2","provider_execution_identity_status":"recorded","requested_seed":20260904,"seed":20260904,"source_revision":"boltz@cb04aeccdd480fd4db707f0bbafde538397fa2ac","status":"scored","tool_seed":20260904}],"design_pose_artifact":{"bytes":474913,"sha256":"d888b4278a008d8c8cca71be0918cc471de348990ee011984dcf466aaa64cd52"},"evidence_class":"experimental-structure-derived-control","sequence":"CVVRFVFRGDLAELMLRAVKDHLKKEGPHWNITSTNNGKELVVRGIHESDAKRIAKWVEKRFPRVHTETQCD","sequence_artifact":{"bytes":104,"sha256":"f00cc95168beabfb63bf6a2184a242f47b7ef1e139fbcfc070692aa7f285955c"},"sequence_length":72,"sequence_sha256":"f7254b7c9a956fae2696bf6d56327a87d1b7c5b074acb3388ca278a3c94cb571","structure_basis":"deposited 8TCG chain C bound to chains A and B"},{"aggregate_metrics":{"ipsae_min_median":0.0,"target_contact_recall_median":0.090909},"candidate_id":"control-negative-composition-shuffle","candidate_manifest":{"bytes":20132,"root":"artifact-root","sha256":"f41b54c0de31a29eb328db414573506b2e16863250b8f7114784316acc449dc6"},"claim_ceiling":"computational-design-hypothesis","class":"target-matched-negative","cofold_observations":[{"artifacts":[{"bytes":463142,"role":"predicted-complex","sha256":"df7bf76d0d477deae95a62f5298fc3e26621d3c2182f82b5cac2bdd484a76d3c"},{"bytes":8046272,"role":"pae","sha256":"e19a61b7c4e20451a8d717b184d2acb51db4b80cd9874db415faf8b468f9d8d8"},{"bytes":3250,"role":"metric-source","sha256":"875539973ecfe7a140c99ca82d8da054865ff09b2da198859bd8377bde3670f8"},{"bytes":474913,"role":"design-pose","sha256":"e2e55bed696766f1c0bc3ae4263657a38d58a3fd60a676a894866ed284cdf757"}],"chain_mapping":{"binder":"A","target":"C"},"environment_identity":"fal-boltz-v1:GPU-H100:1:python-3.12:boltz-2.2.1:torch-2.14.0+cu130","input_chain_mapping":{"A":"C","B":"B","C":"A"},"metrics":{"clash_count":0,"contact_count":31,"hotspot_recovery":0.0,"interface_pae":22.611664,"interface_plddt":64.036897,"ipsae_binder_to_target":0.0,"ipsae_min":0.0,"ipsae_target_to_binder":0.0,"iptm":0.863064,"mapping_status":"ok","sc_dockq":0.0235,"site_contact_iou":0.058824,"target_alignment_rmsd":1.894,"target_contact_precision":0.142857,"target_contact_recall":0.090909},"model_revision":"boltz-2.2.1+cb04aeccdd480fd4db707f0bbafde538397fa2ac","package_version":"2.2.1","phase":"screen","predictor":"boltz2","provider_execution_identity_status":"recorded","requested_seed":20260904,"seed":20260904,"source_revision":"boltz@cb04aeccdd480fd4db707f0bbafde538397fa2ac","status":"scored","tool_seed":20260904}],"composition_matches_positive":true,"design_pose_artifact":{"bytes":474913,"sha256":"e2e55bed696766f1c0bc3ae4263657a38d58a3fd60a676a894866ed284cdf757"},"evidence_class":"computational-control","generation":"Fisher-Yates permutation of the positive-control sequence with Python random.Random(20260904)","sequence":"VLWGILDSHVHRDLFFTVTPLKGDERCAVWKRHEKRNAVQGEFHKVVGERITMKSNEKRAKDCRPTIVNAEL","sequence_artifact":{"bytes":111,"sha256":"71593aadd2a4df6a6d0d26a2fbf5934f2c647cd66aba995f558a6e26651bd0a5"},"sequence_length":72,"sequence_sha256":"e146715e664883be6e9af1853202eba34908291ede718e423b4bf537ee1c1fcb"}],"counts":{"cofold_observations":18,"controls":2,"designed_candidates":16,"promoted_candidates":0,"validated_backbones":8},"evidence_class":"computational-design-hypothesis","execution_state":"partial","ingest_manifest":{"bytes":12421,"root":"artifact-root","sha256":"0cd9ee55ce568a8b5ee36b0f3b9ee63e196435c13ec11881e13aacf005dc1f5a"},"interpretation":"Records are computational design hypotheses. Promotion records prioritize computation; they do not establish affinity, selectivity, activity, safety, or therapeutic benefit.","opportunity_id":"O-ITGB6-8TCG-REFERENCE-RECOVERY","records":[{"aggregate_metrics":{"failed_observation_count":0,"ipsae_min_median":0.394219,"scored_observation_count":1,"target_contact_recall_median":0.0},"artifacts":[{"bytes":114745,"sha256":"cf00e5544af03e88e9586a016eb73463f97b7f1f550cefddbd098e8e4a585e88"},{"bytes":555,"sha256":"b1a1f2f87b006e0f0c1bc1d192a20eec2c0e7d2f4e159192facd069a9eede5fa"},{"bytes":95,"sha256":"37f52af68f131ae3b0a20e1499bcb300ead07a88e45310608e36f7f277b4116b"},{"bytes":468838,"sha256":"4c123ec21d5b47ab2e7d9c44cb448b7bb97db6e5219b9e3cc1670e623b1b150c"},{"bytes":57016,"sha256":"8c17db7d8f5fdeab63d29a244f232cefca0ceca7425c915efab66dd51f4e6843"}],"atlas_id":"pmmr-mucinous-colon","backbone_geometry":{"binder_chain_id":"A","binder_length":72,"contact_cutoff_angstrom":5.0,"contacted_orientation_hotspot_count":8,"contacted_orientation_hotspots":["B127","B129","B183","B218","B219","B220","B221","B316"],"contacted_reference_footprint":{"A":["A148","A149","A150","A178","A213","A214","A215","A218"],"B":["B126","B127","B129","B130","B170","B179","B180","B182","B183","B184","B185","B217","B218","B219","B220","B221","B315","B316"]},"contacted_target_chains":["A","B"],"mapping_status":"ok","minimum_target_binder_distance_angstrom":2.2639,"source_to_output_chain":{"A":"B","B":"C"},"target_ca_rmsd_after_superposition_angstrom":0.0654},"binder_id":"rfd3-8tcg-01-mpnn-01","campaign_id":"8tcg-itgav-itgb6-geometry-recovery","candidate_id":"rfd3-8tcg-01-mpnn-01","claim_ceiling":"computational-design-hypothesis","cofold_observations":[{"artifacts":[{"bytes":461230,"role":"predicted-complex","sha256":"b06987ba4c8566812dcddc8a7103354404cfd336268a0358b5bda375484263b8"},{"bytes":7952028,"role":"pae","sha256":"5294970ccfeb8cc1b212797de11cf7b8ef61fff14cbf7b4b3ccd2b318a09dd22"},{"bytes":3214,"role":"metric-source","sha256":"2f0d20d05ba8f39db4408d225be8f98ee07b38db59a98a88495b9dde7f02a279"},{"bytes":468838,"role":"design-pose","sha256":"4c123ec21d5b47ab2e7d9c44cb448b7bb97db6e5219b9e3cc1670e623b1b150c"}],"chain_mapping":{"binder":"A","target":"C"},"environment_identity":"fal-boltz-v1:GPU-H100:1:python-3.12:boltz-2.2.1:torch-2.14.0+cu130","input_chain_mapping":{"A":"C","B":"B","C":"A"},"metrics":{"clash_count":0,"contact_count":73,"hotspot_recovery":0.0,"interface_pae":6.874233,"interface_plddt":73.009259,"ipsae_binder_to_target":0.633607,"ipsae_min":0.394219,"ipsae_target_to_binder":0.394219,"iptm":0.952634,"mapping_status":"ok","sc_dockq":0.791,"site_contact_iou":0.0,"target_alignment_rmsd":1.1929,"target_contact_precision":0.0,"target_contact_recall":0.0},"model_revision":"boltz-2.2.1+cb04aeccdd480fd4db707f0bbafde538397fa2ac","package_version":"2.2.1","phase":"screen","predictor":"boltz2","provider_execution_identity_status":"recorded","requested_seed":20260904,"seed":20260904,"source_revision":"boltz@cb04aeccdd480fd4db707f0bbafde538397fa2ac","status":"scored","tool_seed":20260904}],"evidence_class":"computational-design-hypothesis","lineage":{"backbone_artifact":{"bytes":114745,"sha256":"cf00e5544af03e88e9586a016eb73463f97b7f1f550cefddbd098e8e4a585e88"},"materialized_design_pose":{"bytes":468838,"sha256":"4c123ec21d5b47ab2e7d9c44cb448b7bb97db6e5219b9e3cc1670e623b1b150c"},"materialized_sequence":{"bytes":95,"sha256":"37f52af68f131ae3b0a20e1499bcb300ead07a88e45310608e36f7f277b4116b"},"parent_backbone_id":"rfd3-8tcg-01","proteinmpnn_fasta":{"bytes":555,"sha256":"b1a1f2f87b006e0f0c1bc1d192a20eec2c0e7d2f4e159192facd069a9eede5fa"},"proteinmpnn_record_ordinal":1,"proteinmpnn_requested_seed":202609041,"screen_candidate_manifest":{"bytes":20132,"root":"artifact-root","sha256":"f41b54c0de31a29eb328db414573506b2e16863250b8f7114784316acc449dc6"}},"molecular_format":"miniprotein","molecular_job":"block","opportunity_id":"O-ITGB6-8TCG-REFERENCE-RECOVERY","ranking_status":"unranked","sequence":"KLPDLGILRRLVRSVARLAVKLGLEELAKKLLEAFANKDYDEAIKLCEEIKKLAPDSESIHKAIEALKKIKA","sequence_design_metrics":{"T":0.1,"global_score":1.4758,"sample":1,"score":0.9252,"seq_recovery":0.5},"sequence_length":72,"sequence_sha256":"1034735bde40c08c507d6708a6d9e0d4154ad258ec4303df25f9f28adf983353","target_id":"T-ENSG00000115221"},{"aggregate_metrics":{"failed_observation_count":0,"ipsae_min_median":0.0,"scored_observation_count":1,"target_contact_recall_median":0.0},"artifacts":[{"bytes":114745,"sha256":"cf00e5544af03e88e9586a016eb73463f97b7f1f550cefddbd098e8e4a585e88"},{"bytes":555,"sha256":"b1a1f2f87b006e0f0c1bc1d192a20eec2c0e7d2f4e159192facd069a9eede5fa"},{"bytes":95,"sha256":"3ad23ab8ea5565c713ec4c358f6f8cb1a0efefd3ede1bb48931178a09b86db60"},{"bytes":468838,"sha256":"efffd8e926b4ff0d4da34d80df4c8ae827a51f1120431a578b3382b08e758d47"},{"bytes":57016,"sha256":"8c17db7d8f5fdeab63d29a244f232cefca0ceca7425c915efab66dd51f4e6843"}],"atlas_id":"pmmr-mucinous-colon","backbone_geometry":{"binder_chain_id":"A","binder_length":72,"contact_cutoff_angstrom":5.0,"contacted_orientation_hotspot_count":8,"contacted_orientation_hotspots":["B127","B129","B183","B218","B219","B220","B221","B316"],"contacted_reference_footprint":{"A":["A148","A149","A150","A178","A213","A214","A215","A218"],"B":["B126","B127","B129","B130","B170","B179","B180","B182","B183","B184","B185","B217","B218","B219","B220","B221","B315","B316"]},"contacted_target_chains":["A","B"],"mapping_status":"ok","minimum_target_binder_distance_angstrom":2.2639,"source_to_output_chain":{"A":"B","B":"C"},"target_ca_rmsd_after_superposition_angstrom":0.0654},"binder_id":"rfd3-8tcg-01-mpnn-02","campaign_id":"8tcg-itgav-itgb6-geometry-recovery","candidate_id":"rfd3-8tcg-01-mpnn-02","claim_ceiling":"computational-design-hypothesis","cofold_observations":[{"artifacts":[{"bytes":458386,"role":"predicted-complex","sha256":"e0c27cc429bbf630c4747f88fd8bfdb68e7f638342a0f58316f6fa3d7746994a"},{"bytes":8037369,"role":"pae","sha256":"202c1750d499e6958b66a32d879e644be484159dbc458310b432a3951b626df1"},{"bytes":3198,"role":"metric-source","sha256":"66001eedca848f616707d300fddb6e5a4dfca60f4f574b3afea6765df1d26656"},{"bytes":468838,"role":"design-pose","sha256":"efffd8e926b4ff0d4da34d80df4c8ae827a51f1120431a578b3382b08e758d47"}],"chain_mapping":{"binder":"A","target":"C"},"environment_identity":"fal-boltz-v1:GPU-H100:1:python-3.12:boltz-2.2.1:torch-2.14.0+cu130","input_chain_mapping":{"A":"C","B":"B","C":"A"},"metrics":{"clash_count":0,"contact_count":13,"hotspot_recovery":0.0,"interface_pae":24.520044,"interface_plddt":74.322667,"ipsae_binder_to_target":0.0,"ipsae_min":0.0,"ipsae_target_to_binder":0.0,"iptm":0.866154,"mapping_status":"ok","sc_dockq":0.0283,"site_contact_iou":0.0,"target_alignment_rmsd":2.0435,"target_contact_precision":0.0,"target_contact_recall":0.0},"model_revision":"boltz-2.2.1+cb04aeccdd480fd4db707f0bbafde538397fa2ac","package_version":"2.2.1","phase":"screen","predictor":"boltz2","provider_execution_identity_status":"recorded","requested_seed":20260904,"seed":20260904,"source_revision":"boltz@cb04aeccdd480fd4db707f0bbafde538397fa2ac","status":"scored","tool_seed":20260904}],"evidence_class":"computational-design-hypothesis","lineage":{"backbone_artifact":{"bytes":114745,"sha256":"cf00e5544af03e88e9586a016eb73463f97b7f1f550cefddbd098e8e4a585e88"},"materialized_design_pose":{"bytes":468838,"sha256":"efffd8e926b4ff0d4da34d80df4c8ae827a51f1120431a578b3382b08e758d47"},"materialized_sequence":{"bytes":95,"sha256":"3ad23ab8ea5565c713ec4c358f6f8cb1a0efefd3ede1bb48931178a09b86db60"},"parent_backbone_id":"rfd3-8tcg-01","proteinmpnn_fasta":{"bytes":555,"sha256":"b1a1f2f87b006e0f0c1bc1d192a20eec2c0e7d2f4e159192facd069a9eede5fa"},"proteinmpnn_record_ordinal":2,"proteinmpnn_requested_seed":202609041,"screen_candidate_manifest":{"bytes":20132,"root":"artifact-root","sha256":"f41b54c0de31a29eb328db414573506b2e16863250b8f7114784316acc449dc6"}},"molecular_format":"miniprotein","molecular_job":"block","opportunity_id":"O-ITGB6-8TCG-REFERENCE-RECOVERY","ranking_status":"unranked","sequence":"ELPDDGILRRLVEACADAAVDLGLEDTAAALRAAFAAKDYDTAIALLEEIKAKDPDNEAITKAITALKAKKA","sequence_design_metrics":{"T":0.1,"global_score":1.4618,"sample":2,"score":0.8937,"seq_recovery":0.5833},"sequence_length":72,"sequence_sha256":"71a9cae70cb11a9a3c838184496c44fd6e9a2bc8d58dd3eac83eb125cdb6bd8c","target_id":"T-ENSG00000115221"},{"aggregate_metrics":{"failed_observation_count":0,"ipsae_min_median":0.0,"scored_observation_count":1,"target_contact_recall_median":0.0},"artifacts":[{"bytes":113691,"sha256":"37d37d7258d29b340481e8fb7061c7a2f3cfc884bc8b52c47ff01edec46d0336"},{"bytes":555,"sha256":"dc7764fc86d5fdf6c03c086a346195017307962aaf969c2059b909b0fd1cc5a0"},{"bytes":95,"sha256":"74792e5e7b9b1926f85b08b296f453575c587cf5316e86577d215542c94ab5db"},{"bytes":466246,"sha256":"d5f16b096203fdab49e6e6a5c7e5b4674bde6de5ee318af7b0b0c6ee40b651df"},{"bytes":57016,"sha256":"8c17db7d8f5fdeab63d29a244f232cefca0ceca7425c915efab66dd51f4e6843"}],"atlas_id":"pmmr-mucinous-colon","backbone_geometry":{"binder_chain_id":"A","binder_length":72,"contact_cutoff_angstrom":5.0,"contacted_orientation_hotspot_count":5,"contacted_orientation_hotspots":["B127","B129","B183","B221","B316"],"contacted_reference_footprint":{"A":["A148","A150","A178","A180","A212","A213","A214","A215","A218"],"B":["B126","B127","B129","B130","B182","B183","B184","B185","B221","B316"]},"contacted_target_chains":["A","B"],"mapping_status":"ok","minimum_target_binder_distance_angstrom":1.8257,"source_to_output_chain":{"A":"B","B":"C"},"target_ca_rmsd_after_superposition_angstrom":0.0654},"binder_id":"rfd3-8tcg-02-mpnn-01","campaign_id":"8tcg-itgav-itgb6-geometry-recovery","candidate_id":"rfd3-8tcg-02-mpnn-01","claim_ceiling":"computational-design-hypothesis","cofold_observations":[{"artifacts":[{"bytes":460361,"role":"predicted-complex","sha256":"5fd40f8af0919b1cbbeeec2d8960c1cbe705dd6bb2d976a40d011bc9a782ca05"},{"bytes":8040512,"role":"pae","sha256":"ec149423d57b3eaf1667f323f614ee2eba7d4cf5f39f842cbd917dc6e11623f7"},{"bytes":3195,"role":"metric-source","sha256":"db64fa66f4a65ec2f326da1970e1892c5cff4e97b738d071001f45a8b5251ac9"},{"bytes":466246,"role":"design-pose","sha256":"d5f16b096203fdab49e6e6a5c7e5b4674bde6de5ee318af7b0b0c6ee40b651df"}],"chain_mapping":{"binder":"A","target":"C"},"environment_identity":"fal-boltz-v1:GPU-H100:1:python-3.12:boltz-2.2.1:torch-2.14.0+cu130","input_chain_mapping":{"A":"C","B":"B","C":"A"},"metrics":{"clash_count":1,"contact_count":33,"hotspot_recovery":0.0,"interface_pae":20.355627,"interface_plddt":74.603846,"ipsae_binder_to_target":0.0,"ipsae_min":0.0,"ipsae_target_to_binder":0.0,"iptm":0.886429,"mapping_status":"ok","sc_dockq":0.0341,"site_contact_iou":0.0,"target_alignment_rmsd":1.866,"target_contact_precision":0.0,"target_contact_recall":0.0},"model_revision":"boltz-2.2.1+cb04aeccdd480fd4db707f0bbafde538397fa2ac","package_version":"2.2.1","phase":"screen","predictor":"boltz2","provider_execution_identity_status":"recorded","requested_seed":20260904,"seed":20260904,"source_revision":"boltz@cb04aeccdd480fd4db707f0bbafde538397fa2ac","status":"scored","tool_seed":20260904}],"evidence_class":"computational-design-hypothesis","lineage":{"backbone_artifact":{"bytes":113691,"sha256":"37d37d7258d29b340481e8fb7061c7a2f3cfc884bc8b52c47ff01edec46d0336"},"materialized_design_pose":{"bytes":466246,"sha256":"d5f16b096203fdab49e6e6a5c7e5b4674bde6de5ee318af7b0b0c6ee40b651df"},"materialized_sequence":{"bytes":95,"sha256":"74792e5e7b9b1926f85b08b296f453575c587cf5316e86577d215542c94ab5db"},"parent_backbone_id":"rfd3-8tcg-02","proteinmpnn_fasta":{"bytes":555,"sha256":"dc7764fc86d5fdf6c03c086a346195017307962aaf969c2059b909b0fd1cc5a0"},"proteinmpnn_record_ordinal":1,"proteinmpnn_requested_seed":202609042,"screen_candidate_manifest":{"bytes":20132,"root":"artifact-root","sha256":"f41b54c0de31a29eb328db414573506b2e16863250b8f7114784316acc449dc6"}},"molecular_format":"miniprotein","molecular_job":"block","opportunity_id":"O-ITGB6-8TCG-REFERENCE-RECOVERY","ranking_status":"unranked","sequence":"SDELKKEADSEIARADYYEAKGKKGNSAYYYDQAAGSYKKAAELYKKLGKEEEAKECNAKAAACQAKADAIR","sequence_design_metrics":{"T":0.1,"global_score":1.491,"sample":1,"score":1.0905,"seq_recovery":0.4167},"sequence_length":72,"sequence_sha256":"f9103d1d2b6026b9d7de8bfd8ff5ccfce9bfd0b6a8bc551bcfa38016df2161e7","target_id":"T-ENSG00000115221"},{"aggregate_metrics":{"failed_observation_count":0,"ipsae_min_median":0.0,"scored_observation_count":1,"target_contact_recall_median":0.0},"artifacts":[{"bytes":113691,"sha256":"37d37d7258d29b340481e8fb7061c7a2f3cfc884bc8b52c47ff01edec46d0336"},{"bytes":555,"sha256":"dc7764fc86d5fdf6c03c086a346195017307962aaf969c2059b909b0fd1cc5a0"},{"bytes":95,"sha256":"156ec7992982a82356f270486404820a356479ef5462b968297e3e408526116d"},{"bytes":466246,"sha256":"cb31801b9bd55563f71c0970b4cd4a8bcc146ab7fc24748891505b8545687975"},{"bytes":57016,"sha256":"8c17db7d8f5fdeab63d29a244f232cefca0ceca7425c915efab66dd51f4e6843"}],"atlas_id":"pmmr-mucinous-colon","backbone_geometry":{"binder_chain_id":"A","binder_length":72,"contact_cutoff_angstrom":5.0,"contacted_orientation_hotspot_count":5,"contacted_orientation_hotspots":["B127","B129","B183","B221","B316"],"contacted_reference_footprint":{"A":["A148","A150","A178","A180","A212","A213","A214","A215","A218"],"B":["B126","B127","B129","B130","B182","B183","B184","B185","B221","B316"]},"contacted_target_chains":["A","B"],"mapping_status":"ok","minimum_target_binder_distance_angstrom":1.8257,"source_to_output_chain":{"A":"B","B":"C"},"target_ca_rmsd_after_superposition_angstrom":0.0654},"binder_id":"rfd3-8tcg-02-mpnn-02","campaign_id":"8tcg-itgav-itgb6-geometry-recovery","candidate_id":"rfd3-8tcg-02-mpnn-02","claim_ceiling":"computational-design-hypothesis","cofold_observations":[{"artifacts":[{"bytes":460598,"role":"predicted-complex","sha256":"920ae41e58326856cf401651cac974548e09885ca22d5fed4ebe1b6347d63248"},{"bytes":8041672,"role":"pae","sha256":"c6403231246f51280ea14d72a08e1c0ad71b079bdc74cd03af0326e371c4b5f5"},{"bytes":3195,"role":"metric-source","sha256":"4abe323669543ecc6537998119cc6d3da129feeb1ced3018c48c7670566c4946"},{"bytes":466246,"role":"design-pose","sha256":"cb31801b9bd55563f71c0970b4cd4a8bcc146ab7fc24748891505b8545687975"}],"chain_mapping":{"binder":"A","target":"C"},"environment_identity":"fal-boltz-v1:GPU-H100:1:python-3.12:boltz-2.2.1:torch-2.14.0+cu130","input_chain_mapping":{"A":"C","B":"B","C":"A"},"metrics":{"clash_count":1,"contact_count":19,"hotspot_recovery":0.0,"interface_pae":24.006141,"interface_plddt":76.672941,"ipsae_binder_to_target":0.0,"ipsae_min":0.0,"ipsae_target_to_binder":0.0,"iptm":0.867732,"mapping_status":"ok","sc_dockq":0.0301,"site_contact_iou":0.0,"target_alignment_rmsd":1.946,"target_contact_precision":0.0,"target_contact_recall":0.0},"model_revision":"boltz-2.2.1+cb04aeccdd480fd4db707f0bbafde538397fa2ac","package_version":"2.2.1","phase":"screen","predictor":"boltz2","provider_execution_identity_status":"recorded","requested_seed":20260904,"seed":20260904,"source_revision":"boltz@cb04aeccdd480fd4db707f0bbafde538397fa2ac","status":"scored","tool_seed":20260904}],"evidence_class":"computational-design-hypothesis","lineage":{"backbone_artifact":{"bytes":113691,"sha256":"37d37d7258d29b340481e8fb7061c7a2f3cfc884bc8b52c47ff01edec46d0336"},"materialized_design_pose":{"bytes":466246,"sha256":"cb31801b9bd55563f71c0970b4cd4a8bcc146ab7fc24748891505b8545687975"},"materialized_sequence":{"bytes":95,"sha256":"156ec7992982a82356f270486404820a356479ef5462b968297e3e408526116d"},"parent_backbone_id":"rfd3-8tcg-02","proteinmpnn_fasta":{"bytes":555,"sha256":"dc7764fc86d5fdf6c03c086a346195017307962aaf969c2059b909b0fd1cc5a0"},"proteinmpnn_record_ordinal":2,"proteinmpnn_requested_seed":202609042,"screen_candidate_manifest":{"bytes":20132,"root":"artifact-root","sha256":"f41b54c0de31a29eb328db414573506b2e16863250b8f7114784316acc449dc6"}},"molecular_format":"miniprotein","molecular_job":"block","opportunity_id":"O-ITGB6-8TCG-REFERENCE-RECOVERY","ranking_status":"unranked","sequence":"AEELKKEADQLAALADYHKARGDKANSAYHYDQAAGAYNKAAELYKKLGNEEKAAEYKAKADAYDAKAKAIR","sequence_design_metrics":{"T":0.1,"global_score":1.4868,"sample":2,"score":1.0714,"seq_recovery":0.4444},"sequence_length":72,"sequence_sha256":"8281e20ca069e226a2f7e36223ec977d3cf204a2a7ae93ec04e4664dc5dcbd7f","target_id":"T-ENSG00000115221"},{"aggregate_metrics":{"failed_observation_count":0,"ipsae_min_median":0.0,"scored_observation_count":1,"target_contact_recall_median":0.0},"artifacts":[{"bytes":113673,"sha256":"d7406ed9e0e5eae75416f65e543102bcfbbd60b0165e8066a4d3dceac6f22734"},{"bytes":555,"sha256":"495c526f8f09423ab509544a7e8e4bcfe225e89916cb9be9feb7a29ea5a4ddba"},{"bytes":95,"sha256":"7e3dd17a60ba1dfc551cfc3338a472c2659d827cacd970aa49044932e5595487"},{"bytes":466327,"sha256":"0bc4018bec0d40f8602b8f46c2c39d4cfe36bbc6fc29f4bf60d65ac63c1a195d"},{"bytes":57016,"sha256":"8c17db7d8f5fdeab63d29a244f232cefca0ceca7425c915efab66dd51f4e6843"}],"atlas_id":"pmmr-mucinous-colon","backbone_geometry":{"binder_chain_id":"A","binder_length":72,"contact_cutoff_angstrom":5.0,"contacted_orientation_hotspot_count":7,"contacted_orientation_hotspots":["B127","B129","B183","B219","B220","B221","B316"],"contacted_reference_footprint":{"A":["A148","A150","A178","A180","A212","A213","A214","A215","A218"],"B":["B126","B127","B129","B130","B182","B183","B184","B185","B215","B219","B220","B221","B315","B316"]},"contacted_target_chains":["A","B"],"mapping_status":"ok","minimum_target_binder_distance_angstrom":2.0329,"source_to_output_chain":{"A":"B","B":"C"},"target_ca_rmsd_after_superposition_angstrom":0.0654},"binder_id":"rfd3-8tcg-03-mpnn-01","campaign_id":"8tcg-itgav-itgb6-geometry-recovery","candidate_id":"rfd3-8tcg-03-mpnn-01","claim_ceiling":"computational-design-hypothesis","cofold_observations":[{"artifacts":[{"bytes":460598,"role":"predicted-complex","sha256":"4674fe5c52d74a344ea0cf27d16eeeedb6aa59de84ae3a0627dd723f1f878d66"},{"bytes":8039699,"role":"pae","sha256":"b247321b790dbef686cdd432d5fe3b0906eedf47f316799da0ec691d92557725"},{"bytes":3201,"role":"metric-source","sha256":"07d31c117547f7e6cd01002cb938339d702185b69adad866504e90f756e8cd6b"},{"bytes":466327,"role":"design-pose","sha256":"0bc4018bec0d40f8602b8f46c2c39d4cfe36bbc6fc29f4bf60d65ac63c1a195d"}],"chain_mapping":{"binder":"A","target":"C"},"environment_identity":"fal-boltz-v1:GPU-H100:1:python-3.12:boltz-2.2.1:torch-2.14.0+cu130","input_chain_mapping":{"A":"C","B":"B","C":"A"},"metrics":{"clash_count":0,"contact_count":27,"hotspot_recovery":0.0,"interface_pae":24.230221,"interface_plddt":71.733333,"ipsae_binder_to_target":0.0,"ipsae_min":0.0,"ipsae_target_to_binder":0.0,"iptm":0.864902,"mapping_status":"ok","sc_dockq":0.0492,"site_contact_iou":0.0,"target_alignment_rmsd":1.9948,"target_contact_precision":0.0,"target_contact_recall":0.0},"model_revision":"boltz-2.2.1+cb04aeccdd480fd4db707f0bbafde538397fa2ac","package_version":"2.2.1","phase":"screen","predictor":"boltz2","provider_execution_identity_status":"recorded","requested_seed":20260904,"seed":20260904,"source_revision":"boltz@cb04aeccdd480fd4db707f0bbafde538397fa2ac","status":"scored","tool_seed":20260904}],"evidence_class":"computational-design-hypothesis","lineage":{"backbone_artifact":{"bytes":113673,"sha256":"d7406ed9e0e5eae75416f65e543102bcfbbd60b0165e8066a4d3dceac6f22734"},"materialized_design_pose":{"bytes":466327,"sha256":"0bc4018bec0d40f8602b8f46c2c39d4cfe36bbc6fc29f4bf60d65ac63c1a195d"},"materialized_sequence":{"bytes":95,"sha256":"7e3dd17a60ba1dfc551cfc3338a472c2659d827cacd970aa49044932e5595487"},"parent_backbone_id":"rfd3-8tcg-03","proteinmpnn_fasta":{"bytes":555,"sha256":"495c526f8f09423ab509544a7e8e4bcfe225e89916cb9be9feb7a29ea5a4ddba"},"proteinmpnn_record_ordinal":1,"proteinmpnn_requested_seed":202609043,"screen_candidate_manifest":{"bytes":20132,"root":"artifact-root","sha256":"f41b54c0de31a29eb328db414573506b2e16863250b8f7114784316acc449dc6"}},"molecular_format":"miniprotein","molecular_job":"block","opportunity_id":"O-ITGB6-8TCG-REFERENCE-RECOVERY","ranking_status":"unranked","sequence":"MTLEESVAELLAKKAKRPGNRNTARQLTLIAIKLMEEGKLEEALELAEEALKADPNNEAARKVLEEVKKKIA","sequence_design_metrics":{"T":0.1,"global_score":1.4861,"sample":1,"score":0.9763,"seq_recovery":0.4722},"sequence_length":72,"sequence_sha256":"ecae8d1fe03a73271432951faecf4331771082c8e01432c0f9d47ea628f69f67","target_id":"T-ENSG00000115221"},{"aggregate_metrics":{"failed_observation_count":0,"ipsae_min_median":0.0,"scored_observation_count":1,"target_contact_recall_median":0.0},"artifacts":[{"bytes":113673,"sha256":"d7406ed9e0e5eae75416f65e543102bcfbbd60b0165e8066a4d3dceac6f22734"},{"bytes":555,"sha256":"495c526f8f09423ab509544a7e8e4bcfe225e89916cb9be9feb7a29ea5a4ddba"},{"bytes":95,"sha256":"bf3aa21e73cc8c760e526d089068797ae4189ac1a0b6ee0d914fa75262cb0b1c"},{"bytes":466327,"sha256":"6167d70ac3e95f491fae4bb54cf542003f4db37dbbc4a6632819b4aa9f3f4bc8"},{"bytes":57016,"sha256":"8c17db7d8f5fdeab63d29a244f232cefca0ceca7425c915efab66dd51f4e6843"}],"atlas_id":"pmmr-mucinous-colon","backbone_geometry":{"binder_chain_id":"A","binder_length":72,"contact_cutoff_angstrom":5.0,"contacted_orientation_hotspot_count":7,"contacted_orientation_hotspots":["B127","B129","B183","B219","B220","B221","B316"],"contacted_reference_footprint":{"A":["A148","A150","A178","A180","A212","A213","A214","A215","A218"],"B":["B126","B127","B129","B130","B182","B183","B184","B185","B215","B219","B220","B221","B315","B316"]},"contacted_target_chains":["A","B"],"mapping_status":"ok","minimum_target_binder_distance_angstrom":2.0329,"source_to_output_chain":{"A":"B","B":"C"},"target_ca_rmsd_after_superposition_angstrom":0.0654},"binder_id":"rfd3-8tcg-03-mpnn-02","campaign_id":"8tcg-itgav-itgb6-geometry-recovery","candidate_id":"rfd3-8tcg-03-mpnn-02","claim_ceiling":"computational-design-hypothesis","cofold_observations":[{"artifacts":[{"bytes":459255,"role":"predicted-complex","sha256":"724277c428f776e8b00ea559a6e6a50f85c32df93b65558c1b0ae73cf551d057"},{"bytes":8052354,"role":"pae","sha256":"829bb48fff2ec4bf7d10669f1a3181a77ff6a5d8342d6ed30a3a626d638560b6"},{"bytes":3208,"role":"metric-source","sha256":"62722a6930f404ae62f5d32a6444669f66a8d817f588b21f4b0ad7bd5ecf1076"},{"bytes":466327,"role":"design-pose","sha256":"6167d70ac3e95f491fae4bb54cf542003f4db37dbbc4a6632819b4aa9f3f4bc8"}],"chain_mapping":{"binder":"A","target":"C"},"environment_identity":"fal-boltz-v1:GPU-H100:1:python-3.12:boltz-2.2.1:torch-2.14.0+cu130","input_chain_mapping":{"A":"C","B":"B","C":"A"},"metrics":{"clash_count":1,"contact_count":52,"hotspot_recovery":0.0,"interface_pae":14.966595,"interface_plddt":73.641905,"ipsae_binder_to_target":0.010696,"ipsae_min":0.0,"ipsae_target_to_binder":0.0,"iptm":0.905598,"mapping_status":"ok","sc_dockq":0.4654,"site_contact_iou":0.0,"target_alignment_rmsd":1.9548,"target_contact_precision":0.0,"target_contact_recall":0.0},"model_revision":"boltz-2.2.1+cb04aeccdd480fd4db707f0bbafde538397fa2ac","package_version":"2.2.1","phase":"screen","predictor":"boltz2","provider_execution_identity_status":"recorded","requested_seed":20260904,"seed":20260904,"source_revision":"boltz@cb04aeccdd480fd4db707f0bbafde538397fa2ac","status":"scored","tool_seed":20260904}],"evidence_class":"computational-design-hypothesis","lineage":{"backbone_artifact":{"bytes":113673,"sha256":"d7406ed9e0e5eae75416f65e543102bcfbbd60b0165e8066a4d3dceac6f22734"},"materialized_design_pose":{"bytes":466327,"sha256":"6167d70ac3e95f491fae4bb54cf542003f4db37dbbc4a6632819b4aa9f3f4bc8"},"materialized_sequence":{"bytes":95,"sha256":"bf3aa21e73cc8c760e526d089068797ae4189ac1a0b6ee0d914fa75262cb0b1c"},"parent_backbone_id":"rfd3-8tcg-03","proteinmpnn_fasta":{"bytes":555,"sha256":"495c526f8f09423ab509544a7e8e4bcfe225e89916cb9be9feb7a29ea5a4ddba"},"proteinmpnn_record_ordinal":2,"proteinmpnn_requested_seed":202609043,"screen_candidate_manifest":{"bytes":20132,"root":"artifact-root","sha256":"f41b54c0de31a29eb328db414573506b2e16863250b8f7114784316acc449dc6"}},"molecular_format":"miniprotein","molecular_job":"block","opportunity_id":"O-ITGB6-8TCG-REFERENCE-RECOVERY","ranking_status":"unranked","sequence":"MSLEESLARLRAKAAKRPSNRNVARQLALAAIYLAKQGRLEEALAVARAALAADPNNEAARRVLAEVEAKLA","sequence_design_metrics":{"T":0.1,"global_score":1.4753,"sample":2,"score":0.9729,"seq_recovery":0.6111},"sequence_length":72,"sequence_sha256":"bf034af5fb6ce4f9bda84b0f0b473e98a0728881f9fd2ce70b2b021e0e9795da","target_id":"T-ENSG00000115221"},{"aggregate_metrics":{"failed_observation_count":0,"ipsae_min_median":0.010759,"scored_observation_count":1,"target_contact_recall_median":0.0},"artifacts":[{"bytes":113299,"sha256":"f2bb1aff2fc3bc70504ee2482924e66c578fb47fc87a66b2eaf02bbf3b26de74"},{"bytes":555,"sha256":"ec8099b9a15359a9be24ea7fb4c28e2c3793c9efb9f15f2e00e298c0c06aadd2"},{"bytes":95,"sha256":"72a414de1d400cdccdec69241138c8fbc48714d657370bf80ed53d92b616472f"},{"bytes":464140,"sha256":"ee9581e46d3d2e7f3a26703af5a52377f05992c1811b6bad1659d910ea422a7f"},{"bytes":57016,"sha256":"8c17db7d8f5fdeab63d29a244f232cefca0ceca7425c915efab66dd51f4e6843"}],"atlas_id":"pmmr-mucinous-colon","backbone_geometry":{"binder_chain_id":"A","binder_length":72,"contact_cutoff_angstrom":5.0,"contacted_orientation_hotspot_count":8,"contacted_orientation_hotspots":["B127","B129","B183","B218","B219","B220","B221","B316"],"contacted_reference_footprint":{"A":["A148","A149","A150","A178","A180","A212","A213","A214","A215","A218"],"B":["B126","B127","B129","B130","B170","B179","B180","B182","B183","B185","B217","B218","B219","B220","B221","B315","B316"]},"contacted_target_chains":["A","B"],"mapping_status":"ok","minimum_target_binder_distance_angstrom":1.4463,"source_to_output_chain":{"A":"B","B":"C"},"target_ca_rmsd_after_superposition_angstrom":0.0654},"binder_id":"rfd3-8tcg-04-mpnn-01","campaign_id":"8tcg-itgav-itgb6-geometry-recovery","candidate_id":"rfd3-8tcg-04-mpnn-01","claim_ceiling":"computational-design-hypothesis","cofold_observations":[{"artifacts":[{"bytes":455858,"role":"predicted-complex","sha256":"43c56d33f8651365f90eb162f5866e2e6606822aa56baa0275832a8b686dfb2c"},{"bytes":8050457,"role":"pae","sha256":"51f23372b98b1adf50507fc3eec2995a1a14a9cd37f894ac84b2749c3fc62ed1"},{"bytes":3218,"role":"metric-source","sha256":"f135839bae8e33000918eeba531ee65c286d66750ae66d47eecc1b37b56d09b3"},{"bytes":464140,"role":"design-pose","sha256":"ee9581e46d3d2e7f3a26703af5a52377f05992c1811b6bad1659d910ea422a7f"}],"chain_mapping":{"binder":"A","target":"C"},"environment_identity":"fal-boltz-v1:GPU-H100:1:python-3.12:boltz-2.2.1:torch-2.14.0+cu130","input_chain_mapping":{"A":"C","B":"B","C":"A"},"metrics":{"clash_count":1,"contact_count":70,"hotspot_recovery":0.0,"interface_pae":14.912293,"interface_plddt":73.514717,"ipsae_binder_to_target":0.010951,"ipsae_min":0.010759,"ipsae_target_to_binder":0.010759,"iptm":0.906808,"mapping_status":"ok","sc_dockq":0.5752,"site_contact_iou":0.0,"target_alignment_rmsd":1.8456,"target_contact_precision":0.0,"target_contact_recall":0.0},"model_revision":"boltz-2.2.1+cb04aeccdd480fd4db707f0bbafde538397fa2ac","package_version":"2.2.1","phase":"screen","predictor":"boltz2","provider_execution_identity_status":"recorded","requested_seed":20260904,"seed":20260904,"source_revision":"boltz@cb04aeccdd480fd4db707f0bbafde538397fa2ac","status":"scored","tool_seed":20260904}],"evidence_class":"computational-design-hypothesis","lineage":{"backbone_artifact":{"bytes":113299,"sha256":"f2bb1aff2fc3bc70504ee2482924e66c578fb47fc87a66b2eaf02bbf3b26de74"},"materialized_design_pose":{"bytes":464140,"sha256":"ee9581e46d3d2e7f3a26703af5a52377f05992c1811b6bad1659d910ea422a7f"},"materialized_sequence":{"bytes":95,"sha256":"72a414de1d400cdccdec69241138c8fbc48714d657370bf80ed53d92b616472f"},"parent_backbone_id":"rfd3-8tcg-04","proteinmpnn_fasta":{"bytes":555,"sha256":"ec8099b9a15359a9be24ea7fb4c28e2c3793c9efb9f15f2e00e298c0c06aadd2"},"proteinmpnn_record_ordinal":1,"proteinmpnn_requested_seed":202609044,"screen_candidate_manifest":{"bytes":20132,"root":"artifact-root","sha256":"f41b54c0de31a29eb328db414573506b2e16863250b8f7114784316acc449dc6"}},"molecular_format":"miniprotein","molecular_job":"block","opportunity_id":"O-ITGB6-8TCG-REFERENCE-RECOVERY","ranking_status":"unranked","sequence":"PSGSQVRGLAGLVARRVQEGTPAAELTALVQASLGLSAAAAAAAVARIAEAAAKRDGVAATRALRDAVRAQR","sequence_design_metrics":{"T":0.1,"global_score":1.4534,"sample":1,"score":0.7514,"seq_recovery":0.5556},"sequence_length":72,"sequence_sha256":"6d1b8cd4ce13d3967c770ab83c0f3653b0f197181f0901b93a04b10699cace6f","target_id":"T-ENSG00000115221"},{"aggregate_metrics":{"failed_observation_count":1,"ipsae_min_median":null,"scored_observation_count":0,"target_contact_recall_median":null},"artifacts":[{"bytes":113299,"sha256":"f2bb1aff2fc3bc70504ee2482924e66c578fb47fc87a66b2eaf02bbf3b26de74"},{"bytes":555,"sha256":"ec8099b9a15359a9be24ea7fb4c28e2c3793c9efb9f15f2e00e298c0c06aadd2"},{"bytes":95,"sha256":"a512fab88fb0a335800170682582cccf454e79072ea362fef0b273d4ae7575a7"},{"bytes":464140,"sha256":"ec74e0ec5d12543c003a12e6aea24ae1f89e0983733c9d9cf9cc103875cc56a5"},{"bytes":57016,"sha256":"8c17db7d8f5fdeab63d29a244f232cefca0ceca7425c915efab66dd51f4e6843"}],"atlas_id":"pmmr-mucinous-colon","backbone_geometry":{"binder_chain_id":"A","binder_length":72,"contact_cutoff_angstrom":5.0,"contacted_orientation_hotspot_count":8,"contacted_orientation_hotspots":["B127","B129","B183","B218","B219","B220","B221","B316"],"contacted_reference_footprint":{"A":["A148","A149","A150","A178","A180","A212","A213","A214","A215","A218"],"B":["B126","B127","B129","B130","B170","B179","B180","B182","B183","B185","B217","B218","B219","B220","B221","B315","B316"]},"contacted_target_chains":["A","B"],"mapping_status":"ok","minimum_target_binder_distance_angstrom":1.4463,"source_to_output_chain":{"A":"B","B":"C"},"target_ca_rmsd_after_superposition_angstrom":0.0654},"binder_id":"rfd3-8tcg-04-mpnn-02","campaign_id":"8tcg-itgav-itgb6-geometry-recovery","candidate_id":"rfd3-8tcg-04-mpnn-02","claim_ceiling":"computational-design-hypothesis","cofold_observations":[{"artifacts":[{"bytes":464140,"role":"design-pose","sha256":"ec74e0ec5d12543c003a12e6aea24ae1f89e0983733c9d9cf9cc103875cc56a5"}],"chain_mapping":{"binder":"A","target":"C"},"environment_identity":null,"failure_code":"binder_lane_interface_scorer_adapter.py-exit-1","failure_reason":"binder_lane_interface_scorer_adapter.py exited 1","input_chain_mapping":null,"metrics":null,"model_revision":"boltz-2.2.1+cb04aeccdd480fd4db707f0bbafde538397fa2ac","package_version":null,"phase":"screen","predictor":"boltz2","provider_execution_identity_status":"not-recorded-on-failure","requested_seed":20260904,"seed":20260904,"source_revision":null,"status":"failed","tool_seed":20260904}],"evidence_class":"computational-design-hypothesis","lineage":{"backbone_artifact":{"bytes":113299,"sha256":"f2bb1aff2fc3bc70504ee2482924e66c578fb47fc87a66b2eaf02bbf3b26de74"},"materialized_design_pose":{"bytes":464140,"sha256":"ec74e0ec5d12543c003a12e6aea24ae1f89e0983733c9d9cf9cc103875cc56a5"},"materialized_sequence":{"bytes":95,"sha256":"a512fab88fb0a335800170682582cccf454e79072ea362fef0b273d4ae7575a7"},"parent_backbone_id":"rfd3-8tcg-04","proteinmpnn_fasta":{"bytes":555,"sha256":"ec8099b9a15359a9be24ea7fb4c28e2c3793c9efb9f15f2e00e298c0c06aadd2"},"proteinmpnn_record_ordinal":2,"proteinmpnn_requested_seed":202609044,"screen_candidate_manifest":{"bytes":20132,"root":"artifact-root","sha256":"f41b54c0de31a29eb328db414573506b2e16863250b8f7114784316acc449dc6"}},"molecular_format":"miniprotein","molecular_job":"block","opportunity_id":"O-ITGB6-8TCG-REFERENCE-RECOVERY","ranking_status":"unranked","sequence":"PSGSQVRGLAGKIARLIQEGVPREELVARLQASLGLSEAAARAAVDAIAAAAEKLDGVAAYHALVDAVRAER","sequence_design_metrics":{"T":0.1,"global_score":1.4824,"sample":2,"score":0.8207,"seq_recovery":0.4722},"sequence_length":72,"sequence_sha256":"cec344956dcfc2128db22d152ba1ef805b9710cc46741e2c782a1698aeefde20","target_id":"T-ENSG00000115221"},{"aggregate_metrics":{"failed_observation_count":0,"ipsae_min_median":0.0,"scored_observation_count":1,"target_contact_recall_median":0.0},"artifacts":[{"bytes":113455,"sha256":"127c0e98337ab2b92de8ac3acc4cc44352b004cfc68fdd3bb7442fced29da3b8"},{"bytes":555,"sha256":"b0d14b459383d419a705505990acfee033371d285d8142f2fbb63ec68342d0a3"},{"bytes":95,"sha256":"8673c29a5f79417b9643f87015f09ff4fd0cfe2180273bb33f06542a05f0638f"},{"bytes":465355,"sha256":"d28876a28ec92b6a4eb5adb6231d02bd1b24e729f04b4a09977f684c7f24a5bf"},{"bytes":57016,"sha256":"8c17db7d8f5fdeab63d29a244f232cefca0ceca7425c915efab66dd51f4e6843"}],"atlas_id":"pmmr-mucinous-colon","backbone_geometry":{"binder_chain_id":"A","binder_length":72,"contact_cutoff_angstrom":5.0,"contacted_orientation_hotspot_count":7,"contacted_orientation_hotspots":["B127","B129","B183","B219","B220","B221","B316"],"contacted_reference_footprint":{"A":["A150","A178","A212","A213","A214","A215","A218"],"B":["B126","B127","B129","B130","B183","B184","B185","B219","B220","B221","B316"]},"contacted_target_chains":["A","B"],"mapping_status":"ok","minimum_target_binder_distance_angstrom":1.5997,"source_to_output_chain":{"A":"B","B":"C"},"target_ca_rmsd_after_superposition_angstrom":0.0654},"binder_id":"rfd3-8tcg-05-mpnn-01","campaign_id":"8tcg-itgav-itgb6-geometry-recovery","candidate_id":"rfd3-8tcg-05-mpnn-01","claim_ceiling":"computational-design-hypothesis","cofold_observations":[{"artifacts":[{"bytes":458465,"role":"predicted-complex","sha256":"1cd5328262ef14cf51f802f0346dfeadfbd75b9d6d9365e94a501ab3bbf87439"},{"bytes":8031249,"role":"pae","sha256":"0e279cef74e0846ce74d169f7b42af1da4262ec7c13a17854345d87d534d5dab"},{"bytes":3197,"role":"metric-source","sha256":"8eea8cc7005d6f25681ee041f878ab02984318326a76729a2a1db732e9dbe08d"},{"bytes":465355,"role":"design-pose","sha256":"d28876a28ec92b6a4eb5adb6231d02bd1b24e729f04b4a09977f684c7f24a5bf"}],"chain_mapping":{"binder":"A","target":"C"},"environment_identity":"fal-boltz-v1:GPU-H100:1:python-3.12:boltz-2.2.1:torch-2.14.0+cu130","input_chain_mapping":{"A":"C","B":"B","C":"A"},"metrics":{"clash_count":0,"contact_count":16,"hotspot_recovery":0.0,"interface_pae":25.778672,"interface_plddt":77.683684,"ipsae_binder_to_target":0.0,"ipsae_min":0.0,"ipsae_target_to_binder":0.0,"iptm":0.864372,"mapping_status":"ok","sc_dockq":0.0289,"site_contact_iou":0.0,"target_alignment_rmsd":1.9644,"target_contact_precision":0.0,"target_contact_recall":0.0},"model_revision":"boltz-2.2.1+cb04aeccdd480fd4db707f0bbafde538397fa2ac","package_version":"2.2.1","phase":"screen","predictor":"boltz2","provider_execution_identity_status":"recorded","requested_seed":20260904,"seed":20260904,"source_revision":"boltz@cb04aeccdd480fd4db707f0bbafde538397fa2ac","status":"scored","tool_seed":20260904}],"evidence_class":"computational-design-hypothesis","lineage":{"backbone_artifact":{"bytes":113455,"sha256":"127c0e98337ab2b92de8ac3acc4cc44352b004cfc68fdd3bb7442fced29da3b8"},"materialized_design_pose":{"bytes":465355,"sha256":"d28876a28ec92b6a4eb5adb6231d02bd1b24e729f04b4a09977f684c7f24a5bf"},"materialized_sequence":{"bytes":95,"sha256":"8673c29a5f79417b9643f87015f09ff4fd0cfe2180273bb33f06542a05f0638f"},"parent_backbone_id":"rfd3-8tcg-05","proteinmpnn_fasta":{"bytes":555,"sha256":"b0d14b459383d419a705505990acfee033371d285d8142f2fbb63ec68342d0a3"},"proteinmpnn_record_ordinal":1,"proteinmpnn_requested_seed":202609045,"screen_candidate_manifest":{"bytes":20132,"root":"artifact-root","sha256":"f41b54c0de31a29eb328db414573506b2e16863250b8f7114784316acc449dc6"}},"molecular_format":"miniprotein","molecular_job":"block","opportunity_id":"O-ITGB6-8TCG-REFERENCE-RECOVERY","ranking_status":"unranked","sequence":"DPLSGAKAKAATLGVLAAVSEVTKETGVEVSEELKSELIKEAKAALEGKAVTAKEAFELAYEIAKKRLLEKV","sequence_design_metrics":{"T":0.1,"global_score":1.4636,"sample":1,"score":0.8564,"seq_recovery":0.5},"sequence_length":72,"sequence_sha256":"1ccb1539071c40ead49660f90176fa5b2da32e61ab3efc0ae8bfbe25adbe6477","target_id":"T-ENSG00000115221"},{"aggregate_metrics":{"failed_observation_count":0,"ipsae_min_median":0.391265,"scored_observation_count":1,"target_contact_recall_median":0.0},"artifacts":[{"bytes":113455,"sha256":"127c0e98337ab2b92de8ac3acc4cc44352b004cfc68fdd3bb7442fced29da3b8"},{"bytes":555,"sha256":"b0d14b459383d419a705505990acfee033371d285d8142f2fbb63ec68342d0a3"},{"bytes":95,"sha256":"28ef5bdb8544f74f536654d0da4b262b404ff051385cb61b420d786bf930887e"},{"bytes":465355,"sha256":"98e470b91491615ac88b319d77bd24a04e9038d961dfd98f3aa632214cf63b28"},{"bytes":57016,"sha256":"8c17db7d8f5fdeab63d29a244f232cefca0ceca7425c915efab66dd51f4e6843"}],"atlas_id":"pmmr-mucinous-colon","backbone_geometry":{"binder_chain_id":"A","binder_length":72,"contact_cutoff_angstrom":5.0,"contacted_orientation_hotspot_count":7,"contacted_orientation_hotspots":["B127","B129","B183","B219","B220","B221","B316"],"contacted_reference_footprint":{"A":["A150","A178","A212","A213","A214","A215","A218"],"B":["B126","B127","B129","B130","B183","B184","B185","B219","B220","B221","B316"]},"contacted_target_chains":["A","B"],"mapping_status":"ok","minimum_target_binder_distance_angstrom":1.5997,"source_to_output_chain":{"A":"B","B":"C"},"target_ca_rmsd_after_superposition_angstrom":0.0654},"binder_id":"rfd3-8tcg-05-mpnn-02","campaign_id":"8tcg-itgav-itgb6-geometry-recovery","candidate_id":"rfd3-8tcg-05-mpnn-02","claim_ceiling":"computational-design-hypothesis","cofold_observations":[{"artifacts":[{"bytes":459887,"role":"predicted-complex","sha256":"68ae05f1d671c215ba5a06f1495c9b96b3ab4f281ba69e480943ff30dae78347"},{"bytes":7955271,"role":"pae","sha256":"0f25ac9064cbf5a791eee4f0789b40abd55ce8e183ddabcf4378f72a51c095e4"},{"bytes":3212,"role":"metric-source","sha256":"472fd89b66be677c9ef85b930d4a78a3191d8d71d3942adfb185f81ceb540d59"},{"bytes":465355,"role":"design-pose","sha256":"98e470b91491615ac88b319d77bd24a04e9038d961dfd98f3aa632214cf63b28"}],"chain_mapping":{"binder":"A","target":"C"},"environment_identity":"fal-boltz-v1:GPU-H100:1:python-3.12:boltz-2.2.1:torch-2.14.0+cu130","input_chain_mapping":{"A":"C","B":"B","C":"A"},"metrics":{"clash_count":1,"contact_count":63,"hotspot_recovery":0.0,"interface_pae":7.142598,"interface_plddt":72.7106,"ipsae_binder_to_target":0.64216,"ipsae_min":0.391265,"ipsae_target_to_binder":0.391265,"iptm":0.950159,"mapping_status":"ok","sc_dockq":0.7337,"site_contact_iou":0.0,"target_alignment_rmsd":1.9363,"target_contact_precision":0.0,"target_contact_recall":0.0},"model_revision":"boltz-2.2.1+cb04aeccdd480fd4db707f0bbafde538397fa2ac","package_version":"2.2.1","phase":"screen","predictor":"boltz2","provider_execution_identity_status":"recorded","requested_seed":20260904,"seed":20260904,"source_revision":"boltz@cb04aeccdd480fd4db707f0bbafde538397fa2ac","status":"scored","tool_seed":20260904}],"evidence_class":"computational-design-hypothesis","lineage":{"backbone_artifact":{"bytes":113455,"sha256":"127c0e98337ab2b92de8ac3acc4cc44352b004cfc68fdd3bb7442fced29da3b8"},"materialized_design_pose":{"bytes":465355,"sha256":"98e470b91491615ac88b319d77bd24a04e9038d961dfd98f3aa632214cf63b28"},"materialized_sequence":{"bytes":95,"sha256":"28ef5bdb8544f74f536654d0da4b262b404ff051385cb61b420d786bf930887e"},"parent_backbone_id":"rfd3-8tcg-05","proteinmpnn_fasta":{"bytes":555,"sha256":"b0d14b459383d419a705505990acfee033371d285d8142f2fbb63ec68342d0a3"},"proteinmpnn_record_ordinal":2,"proteinmpnn_requested_seed":202609045,"screen_candidate_manifest":{"bytes":20132,"root":"artifact-root","sha256":"f41b54c0de31a29eb328db414573506b2e16863250b8f7114784316acc449dc6"}},"molecular_format":"miniprotein","molecular_job":"block","opportunity_id":"O-ITGB6-8TCG-REFERENCE-RECOVERY","ranking_status":"unranked","sequence":"APLSGAKRKAATLGVLAAVSEVEKETGVKVSEETRSELIKKAKEALKGKNVTNKEAFEIAYEIAYKELKEKV","sequence_design_metrics":{"T":0.1,"global_score":1.4465,"sample":2,"score":0.8752,"seq_recovery":0.4444},"sequence_length":72,"sequence_sha256":"5b4978736eae616531cb58e416c4cc09349291de733ed1f236212654d438fb47","target_id":"T-ENSG00000115221"},{"aggregate_metrics":{"failed_observation_count":0,"ipsae_min_median":0.0,"scored_observation_count":1,"target_contact_recall_median":0.0},"artifacts":[{"bytes":112930,"sha256":"9a710edbee01ad50a93d4119f4665463b9112d7215c89f11b186b409dfe4c2c4"},{"bytes":555,"sha256":"d54f412184e00aaf9bb970bf6c11fd6a285ccaa65eb431a39db87c0afc766cc2"},{"bytes":95,"sha256":"faa01a3246aeb94212bec8fc2b382b8006ee496ebb9a8b48f54a6ce3108d3f00"},{"bytes":463816,"sha256":"b5856818b5018895e931c11afb16c43a1910ebd220b5b19df3657352dd5c247e"},{"bytes":57016,"sha256":"8c17db7d8f5fdeab63d29a244f232cefca0ceca7425c915efab66dd51f4e6843"}],"atlas_id":"pmmr-mucinous-colon","backbone_geometry":{"binder_chain_id":"A","binder_length":72,"contact_cutoff_angstrom":5.0,"contacted_orientation_hotspot_count":5,"contacted_orientation_hotspots":["B127","B129","B183","B221","B316"],"contacted_reference_footprint":{"A":["A148","A150","A178","A212","A213","A214","A215","A218"],"B":["B126","B127","B129","B130","B180","B182","B183","B184","B185","B215","B221","B315","B316"]},"contacted_target_chains":["A","B"],"mapping_status":"ok","minimum_target_binder_distance_angstrom":1.8665,"source_to_output_chain":{"A":"B","B":"C"},"target_ca_rmsd_after_superposition_angstrom":0.0654},"binder_id":"rfd3-8tcg-06-mpnn-01","campaign_id":"8tcg-itgav-itgb6-geometry-recovery","candidate_id":"rfd3-8tcg-06-mpnn-01","claim_ceiling":"computational-design-hypothesis","cofold_observations":[{"artifacts":[{"bytes":460045,"role":"predicted-complex","sha256":"683f5d8576c1b30771efa798041a096c58ddd2b4805d199040294eae16355167"},{"bytes":8034212,"role":"pae","sha256":"b11f029073bad70d6b696d6cbf6367245771e6292b327dfe14c33af26329ef45"},{"bytes":3196,"role":"metric-source","sha256":"cb1b2e5cd19e38ec7e969346e77b1bb4a937a9276330be8c7956100ba2c93a1e"},{"bytes":463816,"role":"design-pose","sha256":"b5856818b5018895e931c11afb16c43a1910ebd220b5b19df3657352dd5c247e"}],"chain_mapping":{"binder":"A","target":"C"},"environment_identity":"fal-boltz-v1:GPU-H100:1:python-3.12:boltz-2.2.1:torch-2.14.0+cu130","input_chain_mapping":{"A":"C","B":"B","C":"A"},"metrics":{"clash_count":0,"contact_count":24,"hotspot_recovery":0.0,"interface_pae":27.063201,"interface_plddt":79.887826,"ipsae_binder_to_target":0.0,"ipsae_min":0.0,"ipsae_target_to_binder":0.0,"iptm":0.857469,"mapping_status":"ok","sc_dockq":0.0242,"site_contact_iou":0.0,"target_alignment_rmsd":1.9446,"target_contact_precision":0.0,"target_contact_recall":0.0},"model_revision":"boltz-2.2.1+cb04aeccdd480fd4db707f0bbafde538397fa2ac","package_version":"2.2.1","phase":"screen","predictor":"boltz2","provider_execution_identity_status":"recorded","requested_seed":20260904,"seed":20260904,"source_revision":"boltz@cb04aeccdd480fd4db707f0bbafde538397fa2ac","status":"scored","tool_seed":20260904}],"evidence_class":"computational-design-hypothesis","lineage":{"backbone_artifact":{"bytes":112930,"sha256":"9a710edbee01ad50a93d4119f4665463b9112d7215c89f11b186b409dfe4c2c4"},"materialized_design_pose":{"bytes":463816,"sha256":"b5856818b5018895e931c11afb16c43a1910ebd220b5b19df3657352dd5c247e"},"materialized_sequence":{"bytes":95,"sha256":"faa01a3246aeb94212bec8fc2b382b8006ee496ebb9a8b48f54a6ce3108d3f00"},"parent_backbone_id":"rfd3-8tcg-06","proteinmpnn_fasta":{"bytes":555,"sha256":"d54f412184e00aaf9bb970bf6c11fd6a285ccaa65eb431a39db87c0afc766cc2"},"proteinmpnn_record_ordinal":1,"proteinmpnn_requested_seed":202609046,"screen_candidate_manifest":{"bytes":20132,"root":"artifact-root","sha256":"f41b54c0de31a29eb328db414573506b2e16863250b8f7114784316acc449dc6"}},"molecular_format":"miniprotein","molecular_job":"block","opportunity_id":"O-ITGB6-8TCG-REFERENCE-RECOVERY","ranking_status":"unranked","sequence":"EKKEKAKELIEEAVRLAKEGKVKEALEKVKEATELADNNPEVALLAYTAVRDAAAGLTDDAERAKKKAVELI","sequence_design_metrics":{"T":0.1,"global_score":1.4821,"sample":1,"score":0.9324,"seq_recovery":0.4028},"sequence_length":72,"sequence_sha256":"cb47f3ec535b9a14646ee134ca338f6b19b05707e9f3b1257567be4efc55170d","target_id":"T-ENSG00000115221"},{"aggregate_metrics":{"failed_observation_count":0,"ipsae_min_median":0.0,"scored_observation_count":1,"target_contact_recall_median":0.0},"artifacts":[{"bytes":112930,"sha256":"9a710edbee01ad50a93d4119f4665463b9112d7215c89f11b186b409dfe4c2c4"},{"bytes":555,"sha256":"d54f412184e00aaf9bb970bf6c11fd6a285ccaa65eb431a39db87c0afc766cc2"},{"bytes":95,"sha256":"3a208cb780a8f2d39e2517e44633d46e91901bc85cdd62106afb7487f601f915"},{"bytes":463816,"sha256":"c86552e7ddf381ea58dd8c0a764384bfe7b4e915df08109b41c1239f7d96edcb"},{"bytes":57016,"sha256":"8c17db7d8f5fdeab63d29a244f232cefca0ceca7425c915efab66dd51f4e6843"}],"atlas_id":"pmmr-mucinous-colon","backbone_geometry":{"binder_chain_id":"A","binder_length":72,"contact_cutoff_angstrom":5.0,"contacted_orientation_hotspot_count":5,"contacted_orientation_hotspots":["B127","B129","B183","B221","B316"],"contacted_reference_footprint":{"A":["A148","A150","A178","A212","A213","A214","A215","A218"],"B":["B126","B127","B129","B130","B180","B182","B183","B184","B185","B215","B221","B315","B316"]},"contacted_target_chains":["A","B"],"mapping_status":"ok","minimum_target_binder_distance_angstrom":1.8665,"source_to_output_chain":{"A":"B","B":"C"},"target_ca_rmsd_after_superposition_angstrom":0.0654},"binder_id":"rfd3-8tcg-06-mpnn-02","campaign_id":"8tcg-itgav-itgb6-geometry-recovery","candidate_id":"rfd3-8tcg-06-mpnn-02","claim_ceiling":"computational-design-hypothesis","cofold_observations":[{"artifacts":[{"bytes":459176,"role":"predicted-complex","sha256":"fca3189d6aca63122434ed45e762e39ae88d24639ec4b3a9df901a1d44f1edc4"},{"bytes":8034839,"role":"pae","sha256":"98455d2b0e645c2d88d7fb2972f0d66a9f98268ad1eefd567d5da95e27f21885"},{"bytes":3199,"role":"metric-source","sha256":"9042654be65759ddd869488aa72c4896e5ce620ddda8de2bd910f2c38f63b41b"},{"bytes":463816,"role":"design-pose","sha256":"c86552e7ddf381ea58dd8c0a764384bfe7b4e915df08109b41c1239f7d96edcb"}],"chain_mapping":{"binder":"A","target":"C"},"environment_identity":"fal-boltz-v1:GPU-H100:1:python-3.12:boltz-2.2.1:torch-2.14.0+cu130","input_chain_mapping":{"A":"C","B":"B","C":"A"},"metrics":{"clash_count":0,"contact_count":21,"hotspot_recovery":0.0,"interface_pae":23.168568,"interface_plddt":81.268261,"ipsae_binder_to_target":0.0,"ipsae_min":0.0,"ipsae_target_to_binder":0.0,"iptm":0.870563,"mapping_status":"ok","sc_dockq":0.0265,"site_contact_iou":0.0,"target_alignment_rmsd":1.8894,"target_contact_precision":0.0,"target_contact_recall":0.0},"model_revision":"boltz-2.2.1+cb04aeccdd480fd4db707f0bbafde538397fa2ac","package_version":"2.2.1","phase":"screen","predictor":"boltz2","provider_execution_identity_status":"recorded","requested_seed":20260904,"seed":20260904,"source_revision":"boltz@cb04aeccdd480fd4db707f0bbafde538397fa2ac","status":"scored","tool_seed":20260904}],"evidence_class":"computational-design-hypothesis","lineage":{"backbone_artifact":{"bytes":112930,"sha256":"9a710edbee01ad50a93d4119f4665463b9112d7215c89f11b186b409dfe4c2c4"},"materialized_design_pose":{"bytes":463816,"sha256":"c86552e7ddf381ea58dd8c0a764384bfe7b4e915df08109b41c1239f7d96edcb"},"materialized_sequence":{"bytes":95,"sha256":"3a208cb780a8f2d39e2517e44633d46e91901bc85cdd62106afb7487f601f915"},"parent_backbone_id":"rfd3-8tcg-06","proteinmpnn_fasta":{"bytes":555,"sha256":"d54f412184e00aaf9bb970bf6c11fd6a285ccaa65eb431a39db87c0afc766cc2"},"proteinmpnn_record_ordinal":2,"proteinmpnn_requested_seed":202609046,"screen_candidate_manifest":{"bytes":20132,"root":"artifact-root","sha256":"f41b54c0de31a29eb328db414573506b2e16863250b8f7114784316acc449dc6"}},"molecular_format":"miniprotein","molecular_job":"block","opportunity_id":"O-ITGB6-8TCG-REFERENCE-RECOVERY","ranking_status":"unranked","sequence":"EKKEKAIKLVEEAVELAARGEVKKARELVKKATELANNNPEFALLADSAVRDAAAGDFDDAARAAKKAAELL","sequence_design_metrics":{"T":0.1,"global_score":1.475,"sample":2,"score":0.9523,"seq_recovery":0.4167},"sequence_length":72,"sequence_sha256":"a1f6900b1592b0936cb45d9d2f5cf05aba24d457f04ec1980617998566a88467","target_id":"T-ENSG00000115221"},{"aggregate_metrics":{"failed_observation_count":0,"ipsae_min_median":0.0,"scored_observation_count":1,"target_contact_recall_median":0.0},"artifacts":[{"bytes":114617,"sha256":"e2393bd9c3af5b3452f8773b44ee044363095caac3c41fe2e237997766f32309"},{"bytes":555,"sha256":"92443b54ff997d84ca95383e997ae534781dbd569dcbdbed0a15f9c205fc2345"},{"bytes":95,"sha256":"4413cde7a718046d9e98b80ee6bb03e28e0c5893cffb96fe0a94510d01331dab"},{"bytes":467947,"sha256":"15611f47a2f4723c5702a7d7aa56a714afb52c51e94e8da542cdd69a9a400a56"},{"bytes":57016,"sha256":"8c17db7d8f5fdeab63d29a244f232cefca0ceca7425c915efab66dd51f4e6843"}],"atlas_id":"pmmr-mucinous-colon","backbone_geometry":{"binder_chain_id":"A","binder_length":72,"contact_cutoff_angstrom":5.0,"contacted_orientation_hotspot_count":5,"contacted_orientation_hotspots":["B127","B129","B183","B221","B316"],"contacted_reference_footprint":{"A":["A148","A150","A178","A212","A213","A214","A215","A218"],"B":["B126","B127","B129","B130","B182","B183","B184","B185","B221","B315","B316"]},"contacted_target_chains":["A","B"],"mapping_status":"ok","minimum_target_binder_distance_angstrom":1.8976,"source_to_output_chain":{"A":"B","B":"C"},"target_ca_rmsd_after_superposition_angstrom":0.0654},"binder_id":"rfd3-8tcg-07-mpnn-01","campaign_id":"8tcg-itgav-itgb6-geometry-recovery","candidate_id":"rfd3-8tcg-07-mpnn-01","claim_ceiling":"computational-design-hypothesis","cofold_observations":[{"artifacts":[{"bytes":463047,"role":"predicted-complex","sha256":"a463b5290270c1cb27361a3523956eeb5b37a1c064ce9287d43fa54bf602e0a1"},{"bytes":8043464,"role":"pae","sha256":"a839d57ccb254fc017c888a054c9b749b2565e4aba257343c612836525d43d08"},{"bytes":3199,"role":"metric-source","sha256":"0fb84391de488d01fd607e068d6ba03cd4d1ffb7ef44cef2df48bde87352bf88"},{"bytes":467947,"role":"design-pose","sha256":"15611f47a2f4723c5702a7d7aa56a714afb52c51e94e8da542cdd69a9a400a56"}],"chain_mapping":{"binder":"A","target":"C"},"environment_identity":"fal-boltz-v1:GPU-H100:1:python-3.12:boltz-2.2.1:torch-2.14.0+cu130","input_chain_mapping":{"A":"C","B":"B","C":"A"},"metrics":{"clash_count":0,"contact_count":37,"hotspot_recovery":0.0,"interface_pae":27.252097,"interface_plddt":79.880625,"ipsae_binder_to_target":0.0,"ipsae_min":0.0,"ipsae_target_to_binder":0.0,"iptm":0.850049,"mapping_status":"ok","sc_dockq":0.0297,"site_contact_iou":0.0,"target_alignment_rmsd":1.9517,"target_contact_precision":0.0,"target_contact_recall":0.0},"model_revision":"boltz-2.2.1+cb04aeccdd480fd4db707f0bbafde538397fa2ac","package_version":"2.2.1","phase":"screen","predictor":"boltz2","provider_execution_identity_status":"recorded","requested_seed":20260904,"seed":20260904,"source_revision":"boltz@cb04aeccdd480fd4db707f0bbafde538397fa2ac","status":"scored","tool_seed":20260904}],"evidence_class":"computational-design-hypothesis","lineage":{"backbone_artifact":{"bytes":114617,"sha256":"e2393bd9c3af5b3452f8773b44ee044363095caac3c41fe2e237997766f32309"},"materialized_design_pose":{"bytes":467947,"sha256":"15611f47a2f4723c5702a7d7aa56a714afb52c51e94e8da542cdd69a9a400a56"},"materialized_sequence":{"bytes":95,"sha256":"4413cde7a718046d9e98b80ee6bb03e28e0c5893cffb96fe0a94510d01331dab"},"parent_backbone_id":"rfd3-8tcg-07","proteinmpnn_fasta":{"bytes":555,"sha256":"92443b54ff997d84ca95383e997ae534781dbd569dcbdbed0a15f9c205fc2345"},"proteinmpnn_record_ordinal":1,"proteinmpnn_requested_seed":202609047,"screen_candidate_manifest":{"bytes":20132,"root":"artifact-root","sha256":"f41b54c0de31a29eb328db414573506b2e16863250b8f7114784316acc449dc6"}},"molecular_format":"miniprotein","molecular_job":"block","opportunity_id":"O-ITGB6-8TCG-REFERENCE-RECOVERY","ranking_status":"unranked","sequence":"AEEKIKADPNNSNAWYTLGLEYYAKGNYKEAAEYFEKALAIDPRYVKAHTMLSRVYKKLGNKEKADEIAEKR","sequence_design_metrics":{"T":0.1,"global_score":1.4845,"sample":1,"score":0.9106,"seq_recovery":0.375},"sequence_length":72,"sequence_sha256":"e577fe6e124d9ea82a08aa1697065ccbdd7ee29abe04dd1c29e1cbfb77468ad6","target_id":"T-ENSG00000115221"},{"aggregate_metrics":{"failed_observation_count":1,"ipsae_min_median":null,"scored_observation_count":0,"target_contact_recall_median":null},"artifacts":[{"bytes":114617,"sha256":"e2393bd9c3af5b3452f8773b44ee044363095caac3c41fe2e237997766f32309"},{"bytes":555,"sha256":"92443b54ff997d84ca95383e997ae534781dbd569dcbdbed0a15f9c205fc2345"},{"bytes":95,"sha256":"be8c17c01c5f0485c656a824c5f8e4cce8138b1ca1c459349916ccbb44d030d9"},{"bytes":467947,"sha256":"b18dabc2af9e097e914519a11b1e324a47ed8218a0507a441f5a2725d1d084cb"},{"bytes":57016,"sha256":"8c17db7d8f5fdeab63d29a244f232cefca0ceca7425c915efab66dd51f4e6843"}],"atlas_id":"pmmr-mucinous-colon","backbone_geometry":{"binder_chain_id":"A","binder_length":72,"contact_cutoff_angstrom":5.0,"contacted_orientation_hotspot_count":5,"contacted_orientation_hotspots":["B127","B129","B183","B221","B316"],"contacted_reference_footprint":{"A":["A148","A150","A178","A212","A213","A214","A215","A218"],"B":["B126","B127","B129","B130","B182","B183","B184","B185","B221","B315","B316"]},"contacted_target_chains":["A","B"],"mapping_status":"ok","minimum_target_binder_distance_angstrom":1.8976,"source_to_output_chain":{"A":"B","B":"C"},"target_ca_rmsd_after_superposition_angstrom":0.0654},"binder_id":"rfd3-8tcg-07-mpnn-02","campaign_id":"8tcg-itgav-itgb6-geometry-recovery","candidate_id":"rfd3-8tcg-07-mpnn-02","claim_ceiling":"computational-design-hypothesis","cofold_observations":[{"artifacts":[{"bytes":467947,"role":"design-pose","sha256":"b18dabc2af9e097e914519a11b1e324a47ed8218a0507a441f5a2725d1d084cb"}],"chain_mapping":{"binder":"A","target":"C"},"environment_identity":null,"failure_code":"binder_lane_interface_scorer_adapter.py-exit-1","failure_reason":"binder_lane_interface_scorer_adapter.py exited 1","input_chain_mapping":null,"metrics":null,"model_revision":"boltz-2.2.1+cb04aeccdd480fd4db707f0bbafde538397fa2ac","package_version":null,"phase":"screen","predictor":"boltz2","provider_execution_identity_status":"not-recorded-on-failure","requested_seed":20260904,"seed":20260904,"source_revision":null,"status":"failed","tool_seed":20260904}],"evidence_class":"computational-design-hypothesis","lineage":{"backbone_artifact":{"bytes":114617,"sha256":"e2393bd9c3af5b3452f8773b44ee044363095caac3c41fe2e237997766f32309"},"materialized_design_pose":{"bytes":467947,"sha256":"b18dabc2af9e097e914519a11b1e324a47ed8218a0507a441f5a2725d1d084cb"},"materialized_sequence":{"bytes":95,"sha256":"be8c17c01c5f0485c656a824c5f8e4cce8138b1ca1c459349916ccbb44d030d9"},"parent_backbone_id":"rfd3-8tcg-07","proteinmpnn_fasta":{"bytes":555,"sha256":"92443b54ff997d84ca95383e997ae534781dbd569dcbdbed0a15f9c205fc2345"},"proteinmpnn_record_ordinal":2,"proteinmpnn_requested_seed":202609047,"screen_candidate_manifest":{"bytes":20132,"root":"artifact-root","sha256":"f41b54c0de31a29eb328db414573506b2e16863250b8f7114784316acc449dc6"}},"molecular_format":"miniprotein","molecular_job":"block","opportunity_id":"O-ITGB6-8TCG-REFERENCE-RECOVERY","ranking_status":"unranked","sequence":"YQAKIAADPNNSRAWYALGKEYFAKGDYKNAAAAFEKAIAIDPTFVQAHTYLSRVYNKLGDKAKADAVAEKR","sequence_design_metrics":{"T":0.1,"global_score":1.4565,"sample":2,"score":0.8906,"seq_recovery":0.4444},"sequence_length":72,"sequence_sha256":"e8fe75b974fcb1a7960bbda997be17bf001cd1ad0da6d55b847e74446dd770bb","target_id":"T-ENSG00000115221"},{"aggregate_metrics":{"failed_observation_count":0,"ipsae_min_median":0.0,"scored_observation_count":1,"target_contact_recall_median":0.0},"artifacts":[{"bytes":113523,"sha256":"82e4866e3498b01f245e611e0408b1a797478a1ba4efd1c79707fafde5dededb"},{"bytes":555,"sha256":"976ab06be32e7e4a628c6607a25b90c1e10bbc5f68aae30e4c3ab9c2b6fd3366"},{"bytes":95,"sha256":"3803d3866f87311f562955503e7003d0b9dcf9875ce620daa54567606f9ad6ec"},{"bytes":465922,"sha256":"44eb5c1734cd8515d87fcfa365b7df3da1ba45e7d45c12e8fff99799c924e2d5"},{"bytes":57016,"sha256":"8c17db7d8f5fdeab63d29a244f232cefca0ceca7425c915efab66dd51f4e6843"}],"atlas_id":"pmmr-mucinous-colon","backbone_geometry":{"binder_chain_id":"A","binder_length":72,"contact_cutoff_angstrom":5.0,"contacted_orientation_hotspot_count":8,"contacted_orientation_hotspots":["B127","B129","B183","B218","B219","B220","B221","B316"],"contacted_reference_footprint":{"A":["A150","A177","A178","A180","A212","A213","A214","A215","A218"],"B":["B126","B127","B129","B130","B179","B180","B182","B183","B184","B185","B217","B218","B219","B220","B221","B316"]},"contacted_target_chains":["A","B"],"mapping_status":"ok","minimum_target_binder_distance_angstrom":1.6036,"source_to_output_chain":{"A":"B","B":"C"},"target_ca_rmsd_after_superposition_angstrom":0.0654},"binder_id":"rfd3-8tcg-08-mpnn-01","campaign_id":"8tcg-itgav-itgb6-geometry-recovery","candidate_id":"rfd3-8tcg-08-mpnn-01","claim_ceiling":"computational-design-hypothesis","cofold_observations":[{"artifacts":[{"bytes":459492,"role":"predicted-complex","sha256":"c4b6270945194509ffae8a330af1b0494fe990590942af75e887cf212a108028"},{"bytes":8046945,"role":"pae","sha256":"492fe889722f85ddcbeab2d2495105b565caabd9cd6375af9b98162986775596"},{"bytes":3197,"role":"metric-source","sha256":"c9d358a8c7434caf68df4b1ce239135bf565acf1845579c5806c7b37f3893217"},{"bytes":465922,"role":"design-pose","sha256":"44eb5c1734cd8515d87fcfa365b7df3da1ba45e7d45c12e8fff99799c924e2d5"}],"chain_mapping":{"binder":"A","target":"C"},"environment_identity":"fal-boltz-v1:GPU-H100:1:python-3.12:boltz-2.2.1:torch-2.14.0+cu130","input_chain_mapping":{"A":"C","B":"B","C":"A"},"metrics":{"clash_count":2,"contact_count":20,"hotspot_recovery":0.0,"interface_pae":20.799912,"interface_plddt":81.132632,"ipsae_binder_to_target":0.0,"ipsae_min":0.0,"ipsae_target_to_binder":0.0,"iptm":0.880246,"mapping_status":"ok","sc_dockq":0.2159,"site_contact_iou":0.0,"target_alignment_rmsd":0.7049,"target_contact_precision":0.0,"target_contact_recall":0.0},"model_revision":"boltz-2.2.1+cb04aeccdd480fd4db707f0bbafde538397fa2ac","package_version":"2.2.1","phase":"screen","predictor":"boltz2","provider_execution_identity_status":"recorded","requested_seed":20260904,"seed":20260904,"source_revision":"boltz@cb04aeccdd480fd4db707f0bbafde538397fa2ac","status":"scored","tool_seed":20260904}],"evidence_class":"computational-design-hypothesis","lineage":{"backbone_artifact":{"bytes":113523,"sha256":"82e4866e3498b01f245e611e0408b1a797478a1ba4efd1c79707fafde5dededb"},"materialized_design_pose":{"bytes":465922,"sha256":"44eb5c1734cd8515d87fcfa365b7df3da1ba45e7d45c12e8fff99799c924e2d5"},"materialized_sequence":{"bytes":95,"sha256":"3803d3866f87311f562955503e7003d0b9dcf9875ce620daa54567606f9ad6ec"},"parent_backbone_id":"rfd3-8tcg-08","proteinmpnn_fasta":{"bytes":555,"sha256":"976ab06be32e7e4a628c6607a25b90c1e10bbc5f68aae30e4c3ab9c2b6fd3366"},"proteinmpnn_record_ordinal":1,"proteinmpnn_requested_seed":202609048,"screen_candidate_manifest":{"bytes":20132,"root":"artifact-root","sha256":"f41b54c0de31a29eb328db414573506b2e16863250b8f7114784316acc449dc6"}},"molecular_format":"miniprotein","molecular_job":"block","opportunity_id":"O-ITGB6-8TCG-REFERENCE-RECOVERY","ranking_status":"unranked","sequence":"KIEEAIKAAEEGNLEKAIKLAKEAAKLARSNMETVKYLGSAIKAAKEGNLEKAIESLKKALEIAKKRGLEEA","sequence_design_metrics":{"T":0.1,"global_score":1.4701,"sample":1,"score":0.7257,"seq_recovery":0.4444},"sequence_length":72,"sequence_sha256":"dfe5cba3f2b978c4735e61f80c7638af998c99d2fa17cb227faee0a781b6254c","target_id":"T-ENSG00000115221"},{"aggregate_metrics":{"failed_observation_count":0,"ipsae_min_median":0.0,"scored_observation_count":1,"target_contact_recall_median":0.0},"artifacts":[{"bytes":113523,"sha256":"82e4866e3498b01f245e611e0408b1a797478a1ba4efd1c79707fafde5dededb"},{"bytes":555,"sha256":"976ab06be32e7e4a628c6607a25b90c1e10bbc5f68aae30e4c3ab9c2b6fd3366"},{"bytes":95,"sha256":"492ce758bb9b74e4ca49c6c0a3180ffa6d2ab90edd0120335f5682cf89136b80"},{"bytes":465922,"sha256":"9e8061ff322fd8cf726a7bfe00a7752f9c765e38b2abc3f2193ac1b7b6efe107"},{"bytes":57016,"sha256":"8c17db7d8f5fdeab63d29a244f232cefca0ceca7425c915efab66dd51f4e6843"}],"atlas_id":"pmmr-mucinous-colon","backbone_geometry":{"binder_chain_id":"A","binder_length":72,"contact_cutoff_angstrom":5.0,"contacted_orientation_hotspot_count":8,"contacted_orientation_hotspots":["B127","B129","B183","B218","B219","B220","B221","B316"],"contacted_reference_footprint":{"A":["A150","A177","A178","A180","A212","A213","A214","A215","A218"],"B":["B126","B127","B129","B130","B179","B180","B182","B183","B184","B185","B217","B218","B219","B220","B221","B316"]},"contacted_target_chains":["A","B"],"mapping_status":"ok","minimum_target_binder_distance_angstrom":1.6036,"source_to_output_chain":{"A":"B","B":"C"},"target_ca_rmsd_after_superposition_angstrom":0.0654},"binder_id":"rfd3-8tcg-08-mpnn-02","campaign_id":"8tcg-itgav-itgb6-geometry-recovery","candidate_id":"rfd3-8tcg-08-mpnn-02","claim_ceiling":"computational-design-hypothesis","cofold_observations":[{"artifacts":[{"bytes":456885,"role":"predicted-complex","sha256":"0cca5a3bccfa3437e8d2bc2a928456daafd8254e9f50995522805ca826c202f4"},{"bytes":8038248,"role":"pae","sha256":"1d3fd18d0a722e3669df931926bcb9b060b005c0437d8ba32c929fc7f3818b5e"},{"bytes":3197,"role":"metric-source","sha256":"0967f83f69af2e858a1a1536337af43a506ae12d4b8825c9687e3ea8abc7ad4b"},{"bytes":465922,"role":"design-pose","sha256":"9e8061ff322fd8cf726a7bfe00a7752f9c765e38b2abc3f2193ac1b7b6efe107"}],"chain_mapping":{"binder":"A","target":"C"},"environment_identity":"fal-boltz-v1:GPU-H100:1:python-3.12:boltz-2.2.1:torch-2.14.0+cu130","input_chain_mapping":{"A":"C","B":"B","C":"A"},"metrics":{"clash_count":0,"contact_count":17,"hotspot_recovery":0.0,"interface_pae":20.868679,"interface_plddt":82.005789,"ipsae_binder_to_target":0.0,"ipsae_min":0.0,"ipsae_target_to_binder":0.0,"iptm":0.881411,"mapping_status":"ok","sc_dockq":0.0372,"site_contact_iou":0.0,"target_alignment_rmsd":1.9594,"target_contact_precision":0.0,"target_contact_recall":0.0},"model_revision":"boltz-2.2.1+cb04aeccdd480fd4db707f0bbafde538397fa2ac","package_version":"2.2.1","phase":"screen","predictor":"boltz2","provider_execution_identity_status":"recorded","requested_seed":20260904,"seed":20260904,"source_revision":"boltz@cb04aeccdd480fd4db707f0bbafde538397fa2ac","status":"scored","tool_seed":20260904}],"evidence_class":"computational-design-hypothesis","lineage":{"backbone_artifact":{"bytes":113523,"sha256":"82e4866e3498b01f245e611e0408b1a797478a1ba4efd1c79707fafde5dededb"},"materialized_design_pose":{"bytes":465922,"sha256":"9e8061ff322fd8cf726a7bfe00a7752f9c765e38b2abc3f2193ac1b7b6efe107"},"materialized_sequence":{"bytes":95,"sha256":"492ce758bb9b74e4ca49c6c0a3180ffa6d2ab90edd0120335f5682cf89136b80"},"parent_backbone_id":"rfd3-8tcg-08","proteinmpnn_fasta":{"bytes":555,"sha256":"976ab06be32e7e4a628c6607a25b90c1e10bbc5f68aae30e4c3ab9c2b6fd3366"},"proteinmpnn_record_ordinal":2,"proteinmpnn_requested_seed":202609048,"screen_candidate_manifest":{"bytes":20132,"root":"artifact-root","sha256":"f41b54c0de31a29eb328db414573506b2e16863250b8f7114784316acc449dc6"}},"molecular_format":"miniprotein","molecular_job":"block","opportunity_id":"O-ITGB6-8TCG-REFERENCE-RECOVERY","ranking_status":"unranked","sequence":"LIQKAIDAAKAGDLDKAIALLKEAAKKARGNQETVKWIGAAIEAAKAGDLDGAIAAAEKALENAKKAGDTEA","sequence_design_metrics":{"T":0.1,"global_score":1.4728,"sample":2,"score":0.8122,"seq_recovery":0.5972},"sequence_length":72,"sequence_sha256":"07a90ff3cf2918ee73ce14bd3f15135fc4d2716bb59486299d10aa02b3aad399","target_id":"T-ENSG00000115221"}],"report_import":{"artifact_count":111,"artifact_paths_qualified_for_report":true,"campaign_id":"8tcg-itgav-itgb6-geometry-recovery","candidate_collection_key":"records","controls_imported":true,"observations_imported":true,"source_sha256":"46411b9e141e3f74534b329341bcb20dd246aff19330fdd04ecbf794a3bc02b0"},"routes":[{"checkpoint":"rfd3_foundry_2025_12_01_remapped.ckpt","checkpoint_sha256":"9b3f85923e0d51e9453e15cdd2f8c666e7ce096a60577f57d11bbc54ae6d67c1","environment":"main","hardware":"GPU-H100","model":"RFdiffusion3","provider":"fal","route_role":"locked-plan-route","stage":"backbone-generation"},{"checkpoint":"vanilla_model_weights/v_48_020.pt","checkpoint_sha256":"c9cb4a671d79604111231f8dbfc7c590e06f1197453b7a6854ac6661a642f5bd","environment":"main","hardware":"M","model":"ProteinMPNN","provider":"fal","route_role":"locked-plan-route","stage":"sequence-design"},{"environment":"main","hardware":"GPU-H100","model":"Boltz-2","package_version":"2.2.1","provider":"fal","route_role":"locked-plan-route","source_revision":"cb04aeccdd480fd4db707f0bbafde538397fa2ac","stage":"complex-validation"}],"schema_version":"codex-surface-binder-result-collection/v0.1","source_documents":{"canary_plan":{"bytes":17830,"sha256":"e17ce8cd273a749c4b44e0d2e3a62e83b3d56b8e8f4c2df713b6666768df49a7"},"candidate_manifest":{"bytes":20132,"root":"artifact-root","sha256":"f41b54c0de31a29eb328db414573506b2e16863250b8f7114784316acc449dc6"}},"source_payload":{"atlas_id":"pmmr-mucinous-colon","campaign_id":"8tcg-itgav-itgb6-geometry-recovery","claim_ceiling":"computational-design-hypothesis","control_calibration_status":"passed","controls":[{"aggregate_metrics":{"ipsae_min_median":0.579046,"target_contact_recall_median":0.954545},"candidate_id":"control-positive-8tcg-chain-c","candidate_manifest":{"bytes":20132,"root":"artifact-root","sha256":"f41b54c0de31a29eb328db414573506b2e16863250b8f7114784316acc449dc6"},"claim_ceiling":"computational-design-hypothesis","class":"deposited-positive","cofold_observations":[{"artifacts":[{"bytes":463135,"role":"predicted-complex","sha256":"b80b13861b57973d3252e42655573f5fca7d7751f9e9d0c867da6e729b472c22"},{"bytes":7936857,"role":"pae","sha256":"b82de3c8de614e4c0d3817f38b0beb2e3e8639069abdbbebfa47504623fcd90b"},{"bytes":3252,"role":"metric-source","sha256":"83e3f52a3c85263a4570d4272daec042ae094285350cb5659edcfc0b4f6b87cd"},{"bytes":474913,"role":"design-pose","sha256":"d888b4278a008d8c8cca71be0918cc471de348990ee011984dcf466aaa64cd52"}],"chain_mapping":{"binder":"A","target":"C"},"environment_identity":"fal-boltz-v1:GPU-H100:1:python-3.12:boltz-2.2.1:torch-2.14.0+cu130","input_chain_mapping":{"A":"C","B":"B","C":"A"},"metrics":{"clash_count":0,"contact_count":57,"hotspot_recovery":1.0,"interface_pae":5.811457,"interface_plddt":84.262093,"ipsae_binder_to_target":0.782668,"ipsae_min":0.579046,"ipsae_target_to_binder":0.579046,"iptm":0.959294,"mapping_status":"ok","sc_dockq":0.7463,"site_contact_iou":0.75,"target_alignment_rmsd":1.9594,"target_contact_precision":0.777778,"target_contact_recall":0.954545},"model_revision":"boltz-2.2.1+cb04aeccdd480fd4db707f0bbafde538397fa2ac","package_version":"2.2.1","phase":"screen","predictor":"boltz2","provider_execution_identity_status":"recorded","requested_seed":20260904,"seed":20260904,"source_revision":"boltz@cb04aeccdd480fd4db707f0bbafde538397fa2ac","status":"scored","tool_seed":20260904}],"design_pose_artifact":{"bytes":474913,"sha256":"d888b4278a008d8c8cca71be0918cc471de348990ee011984dcf466aaa64cd52"},"evidence_class":"experimental-structure-derived-control","sequence":"CVVRFVFRGDLAELMLRAVKDHLKKEGPHWNITSTNNGKELVVRGIHESDAKRIAKWVEKRFPRVHTETQCD","sequence_artifact":{"bytes":104,"sha256":"f00cc95168beabfb63bf6a2184a242f47b7ef1e139fbcfc070692aa7f285955c"},"sequence_length":72,"sequence_sha256":"f7254b7c9a956fae2696bf6d56327a87d1b7c5b074acb3388ca278a3c94cb571","structure_basis":"deposited 8TCG chain C bound to chains A and B"},{"aggregate_metrics":{"ipsae_min_median":0.0,"target_contact_recall_median":0.090909},"candidate_id":"control-negative-composition-shuffle","candidate_manifest":{"bytes":20132,"root":"artifact-root","sha256":"f41b54c0de31a29eb328db414573506b2e16863250b8f7114784316acc449dc6"},"claim_ceiling":"computational-design-hypothesis","class":"target-matched-negative","cofold_observations":[{"artifacts":[{"bytes":463142,"role":"predicted-complex","sha256":"df7bf76d0d477deae95a62f5298fc3e26621d3c2182f82b5cac2bdd484a76d3c"},{"bytes":8046272,"role":"pae","sha256":"e19a61b7c4e20451a8d717b184d2acb51db4b80cd9874db415faf8b468f9d8d8"},{"bytes":3250,"role":"metric-source","sha256":"875539973ecfe7a140c99ca82d8da054865ff09b2da198859bd8377bde3670f8"},{"bytes":474913,"role":"design-pose","sha256":"e2e55bed696766f1c0bc3ae4263657a38d58a3fd60a676a894866ed284cdf757"}],"chain_mapping":{"binder":"A","target":"C"},"environment_identity":"fal-boltz-v1:GPU-H100:1:python-3.12:boltz-2.2.1:torch-2.14.0+cu130","input_chain_mapping":{"A":"C","B":"B","C":"A"},"metrics":{"clash_count":0,"contact_count":31,"hotspot_recovery":0.0,"interface_pae":22.611664,"interface_plddt":64.036897,"ipsae_binder_to_target":0.0,"ipsae_min":0.0,"ipsae_target_to_binder":0.0,"iptm":0.863064,"mapping_status":"ok","sc_dockq":0.0235,"site_contact_iou":0.058824,"target_alignment_rmsd":1.894,"target_contact_precision":0.142857,"target_contact_recall":0.090909},"model_revision":"boltz-2.2.1+cb04aeccdd480fd4db707f0bbafde538397fa2ac","package_version":"2.2.1","phase":"screen","predictor":"boltz2","provider_execution_identity_status":"recorded","requested_seed":20260904,"seed":20260904,"source_revision":"boltz@cb04aeccdd480fd4db707f0bbafde538397fa2ac","status":"scored","tool_seed":20260904}],"composition_matches_positive":true,"design_pose_artifact":{"bytes":474913,"sha256":"e2e55bed696766f1c0bc3ae4263657a38d58a3fd60a676a894866ed284cdf757"},"evidence_class":"computational-control","generation":"Fisher-Yates permutation of the positive-control sequence with Python random.Random(20260904)","sequence":"VLWGILDSHVHRDLFFTVTPLKGDERCAVWKRHEKRNAVQGEFHKVVGERITMKSNEKRAKDCRPTIVNAEL","sequence_artifact":{"bytes":111,"sha256":"71593aadd2a4df6a6d0d26a2fbf5934f2c647cd66aba995f558a6e26651bd0a5"},"sequence_length":72,"sequence_sha256":"e146715e664883be6e9af1853202eba34908291ede718e423b4bf537ee1c1fcb"}],"counts":{"cofold_observations":18,"controls":2,"designed_candidates":16,"promoted_candidates":0,"validated_backbones":8},"evidence_class":"computational-design-hypothesis","execution_state":"partial","ingest_manifest":{"bytes":12421,"root":"artifact-root","sha256":"0cd9ee55ce568a8b5ee36b0f3b9ee63e196435c13ec11881e13aacf005dc1f5a"},"interpretation":"Records are computational design hypotheses. Promotion records prioritize computation; they do not establish affinity, selectivity, activity, safety, or therapeutic benefit.","opportunity_id":"O-ITGB6-8TCG-REFERENCE-RECOVERY","records":[{"aggregate_metrics":{"failed_observation_count":0,"ipsae_min_median":0.394219,"scored_observation_count":1,"target_contact_recall_median":0.0},"artifacts":[{"bytes":114745,"sha256":"cf00e5544af03e88e9586a016eb73463f97b7f1f550cefddbd098e8e4a585e88"},{"bytes":555,"sha256":"b1a1f2f87b006e0f0c1bc1d192a20eec2c0e7d2f4e159192facd069a9eede5fa"},{"bytes":95,"sha256":"37f52af68f131ae3b0a20e1499bcb300ead07a88e45310608e36f7f277b4116b"},{"bytes":468838,"sha256":"4c123ec21d5b47ab2e7d9c44cb448b7bb97db6e5219b9e3cc1670e623b1b150c"},{"bytes":57016,"sha256":"8c17db7d8f5fdeab63d29a244f232cefca0ceca7425c915efab66dd51f4e6843"}],"atlas_id":"pmmr-mucinous-colon","backbone_geometry":{"binder_chain_id":"A","binder_length":72,"contact_cutoff_angstrom":5.0,"contacted_orientation_hotspot_count":8,"contacted_orientation_hotspots":["B127","B129","B183","B218","B219","B220","B221","B316"],"contacted_reference_footprint":{"A":["A148","A149","A150","A178","A213","A214","A215","A218"],"B":["B126","B127","B129","B130","B170","B179","B180","B182","B183","B184","B185","B217","B218","B219","B220","B221","B315","B316"]},"contacted_target_chains":["A","B"],"mapping_status":"ok","minimum_target_binder_distance_angstrom":2.2639,"source_to_output_chain":{"A":"B","B":"C"},"target_ca_rmsd_after_superposition_angstrom":0.0654},"binder_id":"rfd3-8tcg-01-mpnn-01","campaign_id":"8tcg-itgav-itgb6-geometry-recovery","candidate_id":"rfd3-8tcg-01-mpnn-01","claim_ceiling":"computational-design-hypothesis","cofold_observations":[{"artifacts":[{"bytes":461230,"role":"predicted-complex","sha256":"b06987ba4c8566812dcddc8a7103354404cfd336268a0358b5bda375484263b8"},{"bytes":7952028,"role":"pae","sha256":"5294970ccfeb8cc1b212797de11cf7b8ef61fff14cbf7b4b3ccd2b318a09dd22"},{"bytes":3214,"role":"metric-source","sha256":"2f0d20d05ba8f39db4408d225be8f98ee07b38db59a98a88495b9dde7f02a279"},{"bytes":468838,"role":"design-pose","sha256":"4c123ec21d5b47ab2e7d9c44cb448b7bb97db6e5219b9e3cc1670e623b1b150c"}],"chain_mapping":{"binder":"A","target":"C"},"environment_identity":"fal-boltz-v1:GPU-H100:1:python-3.12:boltz-2.2.1:torch-2.14.0+cu130","input_chain_mapping":{"A":"C","B":"B","C":"A"},"metrics":{"clash_count":0,"contact_count":73,"hotspot_recovery":0.0,"interface_pae":6.874233,"interface_plddt":73.009259,"ipsae_binder_to_target":0.633607,"ipsae_min":0.394219,"ipsae_target_to_binder":0.394219,"iptm":0.952634,"mapping_status":"ok","sc_dockq":0.791,"site_contact_iou":0.0,"target_alignment_rmsd":1.1929,"target_contact_precision":0.0,"target_contact_recall":0.0},"model_revision":"boltz-2.2.1+cb04aeccdd480fd4db707f0bbafde538397fa2ac","package_version":"2.2.1","phase":"screen","predictor":"boltz2","provider_execution_identity_status":"recorded","requested_seed":20260904,"seed":20260904,"source_revision":"boltz@cb04aeccdd480fd4db707f0bbafde538397fa2ac","status":"scored","tool_seed":20260904}],"evidence_class":"computational-design-hypothesis","lineage":{"backbone_artifact":{"bytes":114745,"sha256":"cf00e5544af03e88e9586a016eb73463f97b7f1f550cefddbd098e8e4a585e88"},"materialized_design_pose":{"bytes":468838,"sha256":"4c123ec21d5b47ab2e7d9c44cb448b7bb97db6e5219b9e3cc1670e623b1b150c"},"materialized_sequence":{"bytes":95,"sha256":"37f52af68f131ae3b0a20e1499bcb300ead07a88e45310608e36f7f277b4116b"},"parent_backbone_id":"rfd3-8tcg-01","proteinmpnn_fasta":{"bytes":555,"sha256":"b1a1f2f87b006e0f0c1bc1d192a20eec2c0e7d2f4e159192facd069a9eede5fa"},"proteinmpnn_record_ordinal":1,"proteinmpnn_requested_seed":202609041,"screen_candidate_manifest":{"bytes":20132,"root":"artifact-root","sha256":"f41b54c0de31a29eb328db414573506b2e16863250b8f7114784316acc449dc6"}},"molecular_format":"miniprotein","molecular_job":"block","opportunity_id":"O-ITGB6-8TCG-REFERENCE-RECOVERY","ranking_status":"unranked","sequence":"KLPDLGILRRLVRSVARLAVKLGLEELAKKLLEAFANKDYDEAIKLCEEIKKLAPDSESIHKAIEALKKIKA","sequence_design_metrics":{"T":0.1,"global_score":1.4758,"sample":1,"score":0.9252,"seq_recovery":0.5},"sequence_length":72,"sequence_sha256":"1034735bde40c08c507d6708a6d9e0d4154ad258ec4303df25f9f28adf983353","target_id":"T-ENSG00000115221"},{"aggregate_metrics":{"failed_observation_count":0,"ipsae_min_median":0.0,"scored_observation_count":1,"target_contact_recall_median":0.0},"artifacts":[{"bytes":114745,"sha256":"cf00e5544af03e88e9586a016eb73463f97b7f1f550cefddbd098e8e4a585e88"},{"bytes":555,"sha256":"b1a1f2f87b006e0f0c1bc1d192a20eec2c0e7d2f4e159192facd069a9eede5fa"},{"bytes":95,"sha256":"3ad23ab8ea5565c713ec4c358f6f8cb1a0efefd3ede1bb48931178a09b86db60"},{"bytes":468838,"sha256":"efffd8e926b4ff0d4da34d80df4c8ae827a51f1120431a578b3382b08e758d47"},{"bytes":57016,"sha256":"8c17db7d8f5fdeab63d29a244f232cefca0ceca7425c915efab66dd51f4e6843"}],"atlas_id":"pmmr-mucinous-colon","backbone_geometry":{"binder_chain_id":"A","binder_length":72,"contact_cutoff_angstrom":5.0,"contacted_orientation_hotspot_count":8,"contacted_orientation_hotspots":["B127","B129","B183","B218","B219","B220","B221","B316"],"contacted_reference_footprint":{"A":["A148","A149","A150","A178","A213","A214","A215","A218"],"B":["B126","B127","B129","B130","B170","B179","B180","B182","B183","B184","B185","B217","B218","B219","B220","B221","B315","B316"]},"contacted_target_chains":["A","B"],"mapping_status":"ok","minimum_target_binder_distance_angstrom":2.2639,"source_to_output_chain":{"A":"B","B":"C"},"target_ca_rmsd_after_superposition_angstrom":0.0654},"binder_id":"rfd3-8tcg-01-mpnn-02","campaign_id":"8tcg-itgav-itgb6-geometry-recovery","candidate_id":"rfd3-8tcg-01-mpnn-02","claim_ceiling":"computational-design-hypothesis","cofold_observations":[{"artifacts":[{"bytes":458386,"role":"predicted-complex","sha256":"e0c27cc429bbf630c4747f88fd8bfdb68e7f638342a0f58316f6fa3d7746994a"},{"bytes":8037369,"role":"pae","sha256":"202c1750d499e6958b66a32d879e644be484159dbc458310b432a3951b626df1"},{"bytes":3198,"role":"metric-source","sha256":"66001eedca848f616707d300fddb6e5a4dfca60f4f574b3afea6765df1d26656"},{"bytes":468838,"role":"design-pose","sha256":"efffd8e926b4ff0d4da34d80df4c8ae827a51f1120431a578b3382b08e758d47"}],"chain_mapping":{"binder":"A","target":"C"},"environment_identity":"fal-boltz-v1:GPU-H100:1:python-3.12:boltz-2.2.1:torch-2.14.0+cu130","input_chain_mapping":{"A":"C","B":"B","C":"A"},"metrics":{"clash_count":0,"contact_count":13,"hotspot_recovery":0.0,"interface_pae":24.520044,"interface_plddt":74.322667,"ipsae_binder_to_target":0.0,"ipsae_min":0.0,"ipsae_target_to_binder":0.0,"iptm":0.866154,"mapping_status":"ok","sc_dockq":0.0283,"site_contact_iou":0.0,"target_alignment_rmsd":2.0435,"target_contact_precision":0.0,"target_contact_recall":0.0},"model_revision":"boltz-2.2.1+cb04aeccdd480fd4db707f0bbafde538397fa2ac","package_version":"2.2.1","phase":"screen","predictor":"boltz2","provider_execution_identity_status":"recorded","requested_seed":20260904,"seed":20260904,"source_revision":"boltz@cb04aeccdd480fd4db707f0bbafde538397fa2ac","status":"scored","tool_seed":20260904}],"evidence_class":"computational-design-hypothesis","lineage":{"backbone_artifact":{"bytes":114745,"sha256":"cf00e5544af03e88e9586a016eb73463f97b7f1f550cefddbd098e8e4a585e88"},"materialized_design_pose":{"bytes":468838,"sha256":"efffd8e926b4ff0d4da34d80df4c8ae827a51f1120431a578b3382b08e758d47"},"materialized_sequence":{"bytes":95,"sha256":"3ad23ab8ea5565c713ec4c358f6f8cb1a0efefd3ede1bb48931178a09b86db60"},"parent_backbone_id":"rfd3-8tcg-01","proteinmpnn_fasta":{"bytes":555,"sha256":"b1a1f2f87b006e0f0c1bc1d192a20eec2c0e7d2f4e159192facd069a9eede5fa"},"proteinmpnn_record_ordinal":2,"proteinmpnn_requested_seed":202609041,"screen_candidate_manifest":{"bytes":20132,"root":"artifact-root","sha256":"f41b54c0de31a29eb328db414573506b2e16863250b8f7114784316acc449dc6"}},"molecular_format":"miniprotein","molecular_job":"block","opportunity_id":"O-ITGB6-8TCG-REFERENCE-RECOVERY","ranking_status":"unranked","sequence":"ELPDDGILRRLVEACADAAVDLGLEDTAAALRAAFAAKDYDTAIALLEEIKAKDPDNEAITKAITALKAKKA","sequence_design_metrics":{"T":0.1,"global_score":1.4618,"sample":2,"score":0.8937,"seq_recovery":0.5833},"sequence_length":72,"sequence_sha256":"71a9cae70cb11a9a3c838184496c44fd6e9a2bc8d58dd3eac83eb125cdb6bd8c","target_id":"T-ENSG00000115221"},{"aggregate_metrics":{"failed_observation_count":0,"ipsae_min_median":0.0,"scored_observation_count":1,"target_contact_recall_median":0.0},"artifacts":[{"bytes":113691,"sha256":"37d37d7258d29b340481e8fb7061c7a2f3cfc884bc8b52c47ff01edec46d0336"},{"bytes":555,"sha256":"dc7764fc86d5fdf6c03c086a346195017307962aaf969c2059b909b0fd1cc5a0"},{"bytes":95,"sha256":"74792e5e7b9b1926f85b08b296f453575c587cf5316e86577d215542c94ab5db"},{"bytes":466246,"sha256":"d5f16b096203fdab49e6e6a5c7e5b4674bde6de5ee318af7b0b0c6ee40b651df"},{"bytes":57016,"sha256":"8c17db7d8f5fdeab63d29a244f232cefca0ceca7425c915efab66dd51f4e6843"}],"atlas_id":"pmmr-mucinous-colon","backbone_geometry":{"binder_chain_id":"A","binder_length":72,"contact_cutoff_angstrom":5.0,"contacted_orientation_hotspot_count":5,"contacted_orientation_hotspots":["B127","B129","B183","B221","B316"],"contacted_reference_footprint":{"A":["A148","A150","A178","A180","A212","A213","A214","A215","A218"],"B":["B126","B127","B129","B130","B182","B183","B184","B185","B221","B316"]},"contacted_target_chains":["A","B"],"mapping_status":"ok","minimum_target_binder_distance_angstrom":1.8257,"source_to_output_chain":{"A":"B","B":"C"},"target_ca_rmsd_after_superposition_angstrom":0.0654},"binder_id":"rfd3-8tcg-02-mpnn-01","campaign_id":"8tcg-itgav-itgb6-geometry-recovery","candidate_id":"rfd3-8tcg-02-mpnn-01","claim_ceiling":"computational-design-hypothesis","cofold_observations":[{"artifacts":[{"bytes":460361,"role":"predicted-complex","sha256":"5fd40f8af0919b1cbbeeec2d8960c1cbe705dd6bb2d976a40d011bc9a782ca05"},{"bytes":8040512,"role":"pae","sha256":"ec149423d57b3eaf1667f323f614ee2eba7d4cf5f39f842cbd917dc6e11623f7"},{"bytes":3195,"role":"metric-source","sha256":"db64fa66f4a65ec2f326da1970e1892c5cff4e97b738d071001f45a8b5251ac9"},{"bytes":466246,"role":"design-pose","sha256":"d5f16b096203fdab49e6e6a5c7e5b4674bde6de5ee318af7b0b0c6ee40b651df"}],"chain_mapping":{"binder":"A","target":"C"},"environment_identity":"fal-boltz-v1:GPU-H100:1:python-3.12:boltz-2.2.1:torch-2.14.0+cu130","input_chain_mapping":{"A":"C","B":"B","C":"A"},"metrics":{"clash_count":1,"contact_count":33,"hotspot_recovery":0.0,"interface_pae":20.355627,"interface_plddt":74.603846,"ipsae_binder_to_target":0.0,"ipsae_min":0.0,"ipsae_target_to_binder":0.0,"iptm":0.886429,"mapping_status":"ok","sc_dockq":0.0341,"site_contact_iou":0.0,"target_alignment_rmsd":1.866,"target_contact_precision":0.0,"target_contact_recall":0.0},"model_revision":"boltz-2.2.1+cb04aeccdd480fd4db707f0bbafde538397fa2ac","package_version":"2.2.1","phase":"screen","predictor":"boltz2","provider_execution_identity_status":"recorded","requested_seed":20260904,"seed":20260904,"source_revision":"boltz@cb04aeccdd480fd4db707f0bbafde538397fa2ac","status":"scored","tool_seed":20260904}],"evidence_class":"computational-design-hypothesis","lineage":{"backbone_artifact":{"bytes":113691,"sha256":"37d37d7258d29b340481e8fb7061c7a2f3cfc884bc8b52c47ff01edec46d0336"},"materialized_design_pose":{"bytes":466246,"sha256":"d5f16b096203fdab49e6e6a5c7e5b4674bde6de5ee318af7b0b0c6ee40b651df"},"materialized_sequence":{"bytes":95,"sha256":"74792e5e7b9b1926f85b08b296f453575c587cf5316e86577d215542c94ab5db"},"parent_backbone_id":"rfd3-8tcg-02","proteinmpnn_fasta":{"bytes":555,"sha256":"dc7764fc86d5fdf6c03c086a346195017307962aaf969c2059b909b0fd1cc5a0"},"proteinmpnn_record_ordinal":1,"proteinmpnn_requested_seed":202609042,"screen_candidate_manifest":{"bytes":20132,"root":"artifact-root","sha256":"f41b54c0de31a29eb328db414573506b2e16863250b8f7114784316acc449dc6"}},"molecular_format":"miniprotein","molecular_job":"block","opportunity_id":"O-ITGB6-8TCG-REFERENCE-RECOVERY","ranking_status":"unranked","sequence":"SDELKKEADSEIARADYYEAKGKKGNSAYYYDQAAGSYKKAAELYKKLGKEEEAKECNAKAAACQAKADAIR","sequence_design_metrics":{"T":0.1,"global_score":1.491,"sample":1,"score":1.0905,"seq_recovery":0.4167},"sequence_length":72,"sequence_sha256":"f9103d1d2b6026b9d7de8bfd8ff5ccfce9bfd0b6a8bc551bcfa38016df2161e7","target_id":"T-ENSG00000115221"},{"aggregate_metrics":{"failed_observation_count":0,"ipsae_min_median":0.0,"scored_observation_count":1,"target_contact_recall_median":0.0},"artifacts":[{"bytes":113691,"sha256":"37d37d7258d29b340481e8fb7061c7a2f3cfc884bc8b52c47ff01edec46d0336"},{"bytes":555,"sha256":"dc7764fc86d5fdf6c03c086a346195017307962aaf969c2059b909b0fd1cc5a0"},{"bytes":95,"sha256":"156ec7992982a82356f270486404820a356479ef5462b968297e3e408526116d"},{"bytes":466246,"sha256":"cb31801b9bd55563f71c0970b4cd4a8bcc146ab7fc24748891505b8545687975"},{"bytes":57016,"sha256":"8c17db7d8f5fdeab63d29a244f232cefca0ceca7425c915efab66dd51f4e6843"}],"atlas_id":"pmmr-mucinous-colon","backbone_geometry":{"binder_chain_id":"A","binder_length":72,"contact_cutoff_angstrom":5.0,"contacted_orientation_hotspot_count":5,"contacted_orientation_hotspots":["B127","B129","B183","B221","B316"],"contacted_reference_footprint":{"A":["A148","A150","A178","A180","A212","A213","A214","A215","A218"],"B":["B126","B127","B129","B130","B182","B183","B184","B185","B221","B316"]},"contacted_target_chains":["A","B"],"mapping_status":"ok","minimum_target_binder_distance_angstrom":1.8257,"source_to_output_chain":{"A":"B","B":"C"},"target_ca_rmsd_after_superposition_angstrom":0.0654},"binder_id":"rfd3-8tcg-02-mpnn-02","campaign_id":"8tcg-itgav-itgb6-geometry-recovery","candidate_id":"rfd3-8tcg-02-mpnn-02","claim_ceiling":"computational-design-hypothesis","cofold_observations":[{"artifacts":[{"bytes":460598,"role":"predicted-complex","sha256":"920ae41e58326856cf401651cac974548e09885ca22d5fed4ebe1b6347d63248"},{"bytes":8041672,"role":"pae","sha256":"c6403231246f51280ea14d72a08e1c0ad71b079bdc74cd03af0326e371c4b5f5"},{"bytes":3195,"role":"metric-source","sha256":"4abe323669543ecc6537998119cc6d3da129feeb1ced3018c48c7670566c4946"},{"bytes":466246,"role":"design-pose","sha256":"cb31801b9bd55563f71c0970b4cd4a8bcc146ab7fc24748891505b8545687975"}],"chain_mapping":{"binder":"A","target":"C"},"environment_identity":"fal-boltz-v1:GPU-H100:1:python-3.12:boltz-2.2.1:torch-2.14.0+cu130","input_chain_mapping":{"A":"C","B":"B","C":"A"},"metrics":{"clash_count":1,"contact_count":19,"hotspot_recovery":0.0,"interface_pae":24.006141,"interface_plddt":76.672941,"ipsae_binder_to_target":0.0,"ipsae_min":0.0,"ipsae_target_to_binder":0.0,"iptm":0.867732,"mapping_status":"ok","sc_dockq":0.0301,"site_contact_iou":0.0,"target_alignment_rmsd":1.946,"target_contact_precision":0.0,"target_contact_recall":0.0},"model_revision":"boltz-2.2.1+cb04aeccdd480fd4db707f0bbafde538397fa2ac","package_version":"2.2.1","phase":"screen","predictor":"boltz2","provider_execution_identity_status":"recorded","requested_seed":20260904,"seed":20260904,"source_revision":"boltz@cb04aeccdd480fd4db707f0bbafde538397fa2ac","status":"scored","tool_seed":20260904}],"evidence_class":"computational-design-hypothesis","lineage":{"backbone_artifact":{"bytes":113691,"sha256":"37d37d7258d29b340481e8fb7061c7a2f3cfc884bc8b52c47ff01edec46d0336"},"materialized_design_pose":{"bytes":466246,"sha256":"cb31801b9bd55563f71c0970b4cd4a8bcc146ab7fc24748891505b8545687975"},"materialized_sequence":{"bytes":95,"sha256":"156ec7992982a82356f270486404820a356479ef5462b968297e3e408526116d"},"parent_backbone_id":"rfd3-8tcg-02","proteinmpnn_fasta":{"bytes":555,"sha256":"dc7764fc86d5fdf6c03c086a346195017307962aaf969c2059b909b0fd1cc5a0"},"proteinmpnn_record_ordinal":2,"proteinmpnn_requested_seed":202609042,"screen_candidate_manifest":{"bytes":20132,"root":"artifact-root","sha256":"f41b54c0de31a29eb328db414573506b2e16863250b8f7114784316acc449dc6"}},"molecular_format":"miniprotein","molecular_job":"block","opportunity_id":"O-ITGB6-8TCG-REFERENCE-RECOVERY","ranking_status":"unranked","sequence":"AEELKKEADQLAALADYHKARGDKANSAYHYDQAAGAYNKAAELYKKLGNEEKAAEYKAKADAYDAKAKAIR","sequence_design_metrics":{"T":0.1,"global_score":1.4868,"sample":2,"score":1.0714,"seq_recovery":0.4444},"sequence_length":72,"sequence_sha256":"8281e20ca069e226a2f7e36223ec977d3cf204a2a7ae93ec04e4664dc5dcbd7f","target_id":"T-ENSG00000115221"},{"aggregate_metrics":{"failed_observation_count":0,"ipsae_min_median":0.0,"scored_observation_count":1,"target_contact_recall_median":0.0},"artifacts":[{"bytes":113673,"sha256":"d7406ed9e0e5eae75416f65e543102bcfbbd60b0165e8066a4d3dceac6f22734"},{"bytes":555,"sha256":"495c526f8f09423ab509544a7e8e4bcfe225e89916cb9be9feb7a29ea5a4ddba"},{"bytes":95,"sha256":"7e3dd17a60ba1dfc551cfc3338a472c2659d827cacd970aa49044932e5595487"},{"bytes":466327,"sha256":"0bc4018bec0d40f8602b8f46c2c39d4cfe36bbc6fc29f4bf60d65ac63c1a195d"},{"bytes":57016,"sha256":"8c17db7d8f5fdeab63d29a244f232cefca0ceca7425c915efab66dd51f4e6843"}],"atlas_id":"pmmr-mucinous-colon","backbone_geometry":{"binder_chain_id":"A","binder_length":72,"contact_cutoff_angstrom":5.0,"contacted_orientation_hotspot_count":7,"contacted_orientation_hotspots":["B127","B129","B183","B219","B220","B221","B316"],"contacted_reference_footprint":{"A":["A148","A150","A178","A180","A212","A213","A214","A215","A218"],"B":["B126","B127","B129","B130","B182","B183","B184","B185","B215","B219","B220","B221","B315","B316"]},"contacted_target_chains":["A","B"],"mapping_status":"ok","minimum_target_binder_distance_angstrom":2.0329,"source_to_output_chain":{"A":"B","B":"C"},"target_ca_rmsd_after_superposition_angstrom":0.0654},"binder_id":"rfd3-8tcg-03-mpnn-01","campaign_id":"8tcg-itgav-itgb6-geometry-recovery","candidate_id":"rfd3-8tcg-03-mpnn-01","claim_ceiling":"computational-design-hypothesis","cofold_observations":[{"artifacts":[{"bytes":460598,"role":"predicted-complex","sha256":"4674fe5c52d74a344ea0cf27d16eeeedb6aa59de84ae3a0627dd723f1f878d66"},{"bytes":8039699,"role":"pae","sha256":"b247321b790dbef686cdd432d5fe3b0906eedf47f316799da0ec691d92557725"},{"bytes":3201,"role":"metric-source","sha256":"07d31c117547f7e6cd01002cb938339d702185b69adad866504e90f756e8cd6b"},{"bytes":466327,"role":"design-pose","sha256":"0bc4018bec0d40f8602b8f46c2c39d4cfe36bbc6fc29f4bf60d65ac63c1a195d"}],"chain_mapping":{"binder":"A","target":"C"},"environment_identity":"fal-boltz-v1:GPU-H100:1:python-3.12:boltz-2.2.1:torch-2.14.0+cu130","input_chain_mapping":{"A":"C","B":"B","C":"A"},"metrics":{"clash_count":0,"contact_count":27,"hotspot_recovery":0.0,"interface_pae":24.230221,"interface_plddt":71.733333,"ipsae_binder_to_target":0.0,"ipsae_min":0.0,"ipsae_target_to_binder":0.0,"iptm":0.864902,"mapping_status":"ok","sc_dockq":0.0492,"site_contact_iou":0.0,"target_alignment_rmsd":1.9948,"target_contact_precision":0.0,"target_contact_recall":0.0},"model_revision":"boltz-2.2.1+cb04aeccdd480fd4db707f0bbafde538397fa2ac","package_version":"2.2.1","phase":"screen","predictor":"boltz2","provider_execution_identity_status":"recorded","requested_seed":20260904,"seed":20260904,"source_revision":"boltz@cb04aeccdd480fd4db707f0bbafde538397fa2ac","status":"scored","tool_seed":20260904}],"evidence_class":"computational-design-hypothesis","lineage":{"backbone_artifact":{"bytes":113673,"sha256":"d7406ed9e0e5eae75416f65e543102bcfbbd60b0165e8066a4d3dceac6f22734"},"materialized_design_pose":{"bytes":466327,"sha256":"0bc4018bec0d40f8602b8f46c2c39d4cfe36bbc6fc29f4bf60d65ac63c1a195d"},"materialized_sequence":{"bytes":95,"sha256":"7e3dd17a60ba1dfc551cfc3338a472c2659d827cacd970aa49044932e5595487"},"parent_backbone_id":"rfd3-8tcg-03","proteinmpnn_fasta":{"bytes":555,"sha256":"495c526f8f09423ab509544a7e8e4bcfe225e89916cb9be9feb7a29ea5a4ddba"},"proteinmpnn_record_ordinal":1,"proteinmpnn_requested_seed":202609043,"screen_candidate_manifest":{"bytes":20132,"root":"artifact-root","sha256":"f41b54c0de31a29eb328db414573506b2e16863250b8f7114784316acc449dc6"}},"molecular_format":"miniprotein","molecular_job":"block","opportunity_id":"O-ITGB6-8TCG-REFERENCE-RECOVERY","ranking_status":"unranked","sequence":"MTLEESVAELLAKKAKRPGNRNTARQLTLIAIKLMEEGKLEEALELAEEALKADPNNEAARKVLEEVKKKIA","sequence_design_metrics":{"T":0.1,"global_score":1.4861,"sample":1,"score":0.9763,"seq_recovery":0.4722},"sequence_length":72,"sequence_sha256":"ecae8d1fe03a73271432951faecf4331771082c8e01432c0f9d47ea628f69f67","target_id":"T-ENSG00000115221"},{"aggregate_metrics":{"failed_observation_count":0,"ipsae_min_median":0.0,"scored_observation_count":1,"target_contact_recall_median":0.0},"artifacts":[{"bytes":113673,"sha256":"d7406ed9e0e5eae75416f65e543102bcfbbd60b0165e8066a4d3dceac6f22734"},{"bytes":555,"sha256":"495c526f8f09423ab509544a7e8e4bcfe225e89916cb9be9feb7a29ea5a4ddba"},{"bytes":95,"sha256":"bf3aa21e73cc8c760e526d089068797ae4189ac1a0b6ee0d914fa75262cb0b1c"},{"bytes":466327,"sha256":"6167d70ac3e95f491fae4bb54cf542003f4db37dbbc4a6632819b4aa9f3f4bc8"},{"bytes":57016,"sha256":"8c17db7d8f5fdeab63d29a244f232cefca0ceca7425c915efab66dd51f4e6843"}],"atlas_id":"pmmr-mucinous-colon","backbone_geometry":{"binder_chain_id":"A","binder_length":72,"contact_cutoff_angstrom":5.0,"contacted_orientation_hotspot_count":7,"contacted_orientation_hotspots":["B127","B129","B183","B219","B220","B221","B316"],"contacted_reference_footprint":{"A":["A148","A150","A178","A180","A212","A213","A214","A215","A218"],"B":["B126","B127","B129","B130","B182","B183","B184","B185","B215","B219","B220","B221","B315","B316"]},"contacted_target_chains":["A","B"],"mapping_status":"ok","minimum_target_binder_distance_angstrom":2.0329,"source_to_output_chain":{"A":"B","B":"C"},"target_ca_rmsd_after_superposition_angstrom":0.0654},"binder_id":"rfd3-8tcg-03-mpnn-02","campaign_id":"8tcg-itgav-itgb6-geometry-recovery","candidate_id":"rfd3-8tcg-03-mpnn-02","claim_ceiling":"computational-design-hypothesis","cofold_observations":[{"artifacts":[{"bytes":459255,"role":"predicted-complex","sha256":"724277c428f776e8b00ea559a6e6a50f85c32df93b65558c1b0ae73cf551d057"},{"bytes":8052354,"role":"pae","sha256":"829bb48fff2ec4bf7d10669f1a3181a77ff6a5d8342d6ed30a3a626d638560b6"},{"bytes":3208,"role":"metric-source","sha256":"62722a6930f404ae62f5d32a6444669f66a8d817f588b21f4b0ad7bd5ecf1076"},{"bytes":466327,"role":"design-pose","sha256":"6167d70ac3e95f491fae4bb54cf542003f4db37dbbc4a6632819b4aa9f3f4bc8"}],"chain_mapping":{"binder":"A","target":"C"},"environment_identity":"fal-boltz-v1:GPU-H100:1:python-3.12:boltz-2.2.1:torch-2.14.0+cu130","input_chain_mapping":{"A":"C","B":"B","C":"A"},"metrics":{"clash_count":1,"contact_count":52,"hotspot_recovery":0.0,"interface_pae":14.966595,"interface_plddt":73.641905,"ipsae_binder_to_target":0.010696,"ipsae_min":0.0,"ipsae_target_to_binder":0.0,"iptm":0.905598,"mapping_status":"ok","sc_dockq":0.4654,"site_contact_iou":0.0,"target_alignment_rmsd":1.9548,"target_contact_precision":0.0,"target_contact_recall":0.0},"model_revision":"boltz-2.2.1+cb04aeccdd480fd4db707f0bbafde538397fa2ac","package_version":"2.2.1","phase":"screen","predictor":"boltz2","provider_execution_identity_status":"recorded","requested_seed":20260904,"seed":20260904,"source_revision":"boltz@cb04aeccdd480fd4db707f0bbafde538397fa2ac","status":"scored","tool_seed":20260904}],"evidence_class":"computational-design-hypothesis","lineage":{"backbone_artifact":{"bytes":113673,"sha256":"d7406ed9e0e5eae75416f65e543102bcfbbd60b0165e8066a4d3dceac6f22734"},"materialized_design_pose":{"bytes":466327,"sha256":"6167d70ac3e95f491fae4bb54cf542003f4db37dbbc4a6632819b4aa9f3f4bc8"},"materialized_sequence":{"bytes":95,"sha256":"bf3aa21e73cc8c760e526d089068797ae4189ac1a0b6ee0d914fa75262cb0b1c"},"parent_backbone_id":"rfd3-8tcg-03","proteinmpnn_fasta":{"bytes":555,"sha256":"495c526f8f09423ab509544a7e8e4bcfe225e89916cb9be9feb7a29ea5a4ddba"},"proteinmpnn_record_ordinal":2,"proteinmpnn_requested_seed":202609043,"screen_candidate_manifest":{"bytes":20132,"root":"artifact-root","sha256":"f41b54c0de31a29eb328db414573506b2e16863250b8f7114784316acc449dc6"}},"molecular_format":"miniprotein","molecular_job":"block","opportunity_id":"O-ITGB6-8TCG-REFERENCE-RECOVERY","ranking_status":"unranked","sequence":"MSLEESLARLRAKAAKRPSNRNVARQLALAAIYLAKQGRLEEALAVARAALAADPNNEAARRVLAEVEAKLA","sequence_design_metrics":{"T":0.1,"global_score":1.4753,"sample":2,"score":0.9729,"seq_recovery":0.6111},"sequence_length":72,"sequence_sha256":"bf034af5fb6ce4f9bda84b0f0b473e98a0728881f9fd2ce70b2b021e0e9795da","target_id":"T-ENSG00000115221"},{"aggregate_metrics":{"failed_observation_count":0,"ipsae_min_median":0.010759,"scored_observation_count":1,"target_contact_recall_median":0.0},"artifacts":[{"bytes":113299,"sha256":"f2bb1aff2fc3bc70504ee2482924e66c578fb47fc87a66b2eaf02bbf3b26de74"},{"bytes":555,"sha256":"ec8099b9a15359a9be24ea7fb4c28e2c3793c9efb9f15f2e00e298c0c06aadd2"},{"bytes":95,"sha256":"72a414de1d400cdccdec69241138c8fbc48714d657370bf80ed53d92b616472f"},{"bytes":464140,"sha256":"ee9581e46d3d2e7f3a26703af5a52377f05992c1811b6bad1659d910ea422a7f"},{"bytes":57016,"sha256":"8c17db7d8f5fdeab63d29a244f232cefca0ceca7425c915efab66dd51f4e6843"}],"atlas_id":"pmmr-mucinous-colon","backbone_geometry":{"binder_chain_id":"A","binder_length":72,"contact_cutoff_angstrom":5.0,"contacted_orientation_hotspot_count":8,"contacted_orientation_hotspots":["B127","B129","B183","B218","B219","B220","B221","B316"],"contacted_reference_footprint":{"A":["A148","A149","A150","A178","A180","A212","A213","A214","A215","A218"],"B":["B126","B127","B129","B130","B170","B179","B180","B182","B183","B185","B217","B218","B219","B220","B221","B315","B316"]},"contacted_target_chains":["A","B"],"mapping_status":"ok","minimum_target_binder_distance_angstrom":1.4463,"source_to_output_chain":{"A":"B","B":"C"},"target_ca_rmsd_after_superposition_angstrom":0.0654},"binder_id":"rfd3-8tcg-04-mpnn-01","campaign_id":"8tcg-itgav-itgb6-geometry-recovery","candidate_id":"rfd3-8tcg-04-mpnn-01","claim_ceiling":"computational-design-hypothesis","cofold_observations":[{"artifacts":[{"bytes":455858,"role":"predicted-complex","sha256":"43c56d33f8651365f90eb162f5866e2e6606822aa56baa0275832a8b686dfb2c"},{"bytes":8050457,"role":"pae","sha256":"51f23372b98b1adf50507fc3eec2995a1a14a9cd37f894ac84b2749c3fc62ed1"},{"bytes":3218,"role":"metric-source","sha256":"f135839bae8e33000918eeba531ee65c286d66750ae66d47eecc1b37b56d09b3"},{"bytes":464140,"role":"design-pose","sha256":"ee9581e46d3d2e7f3a26703af5a52377f05992c1811b6bad1659d910ea422a7f"}],"chain_mapping":{"binder":"A","target":"C"},"environment_identity":"fal-boltz-v1:GPU-H100:1:python-3.12:boltz-2.2.1:torch-2.14.0+cu130","input_chain_mapping":{"A":"C","B":"B","C":"A"},"metrics":{"clash_count":1,"contact_count":70,"hotspot_recovery":0.0,"interface_pae":14.912293,"interface_plddt":73.514717,"ipsae_binder_to_target":0.010951,"ipsae_min":0.010759,"ipsae_target_to_binder":0.010759,"iptm":0.906808,"mapping_status":"ok","sc_dockq":0.5752,"site_contact_iou":0.0,"target_alignment_rmsd":1.8456,"target_contact_precision":0.0,"target_contact_recall":0.0},"model_revision":"boltz-2.2.1+cb04aeccdd480fd4db707f0bbafde538397fa2ac","package_version":"2.2.1","phase":"screen","predictor":"boltz2","provider_execution_identity_status":"recorded","requested_seed":20260904,"seed":20260904,"source_revision":"boltz@cb04aeccdd480fd4db707f0bbafde538397fa2ac","status":"scored","tool_seed":20260904}],"evidence_class":"computational-design-hypothesis","lineage":{"backbone_artifact":{"bytes":113299,"sha256":"f2bb1aff2fc3bc70504ee2482924e66c578fb47fc87a66b2eaf02bbf3b26de74"},"materialized_design_pose":{"bytes":464140,"sha256":"ee9581e46d3d2e7f3a26703af5a52377f05992c1811b6bad1659d910ea422a7f"},"materialized_sequence":{"bytes":95,"sha256":"72a414de1d400cdccdec69241138c8fbc48714d657370bf80ed53d92b616472f"},"parent_backbone_id":"rfd3-8tcg-04","proteinmpnn_fasta":{"bytes":555,"sha256":"ec8099b9a15359a9be24ea7fb4c28e2c3793c9efb9f15f2e00e298c0c06aadd2"},"proteinmpnn_record_ordinal":1,"proteinmpnn_requested_seed":202609044,"screen_candidate_manifest":{"bytes":20132,"root":"artifact-root","sha256":"f41b54c0de31a29eb328db414573506b2e16863250b8f7114784316acc449dc6"}},"molecular_format":"miniprotein","molecular_job":"block","opportunity_id":"O-ITGB6-8TCG-REFERENCE-RECOVERY","ranking_status":"unranked","sequence":"PSGSQVRGLAGLVARRVQEGTPAAELTALVQASLGLSAAAAAAAVARIAEAAAKRDGVAATRALRDAVRAQR","sequence_design_metrics":{"T":0.1,"global_score":1.4534,"sample":1,"score":0.7514,"seq_recovery":0.5556},"sequence_length":72,"sequence_sha256":"6d1b8cd4ce13d3967c770ab83c0f3653b0f197181f0901b93a04b10699cace6f","target_id":"T-ENSG00000115221"},{"aggregate_metrics":{"failed_observation_count":1,"ipsae_min_median":null,"scored_observation_count":0,"target_contact_recall_median":null},"artifacts":[{"bytes":113299,"sha256":"f2bb1aff2fc3bc70504ee2482924e66c578fb47fc87a66b2eaf02bbf3b26de74"},{"bytes":555,"sha256":"ec8099b9a15359a9be24ea7fb4c28e2c3793c9efb9f15f2e00e298c0c06aadd2"},{"bytes":95,"sha256":"a512fab88fb0a335800170682582cccf454e79072ea362fef0b273d4ae7575a7"},{"bytes":464140,"sha256":"ec74e0ec5d12543c003a12e6aea24ae1f89e0983733c9d9cf9cc103875cc56a5"},{"bytes":57016,"sha256":"8c17db7d8f5fdeab63d29a244f232cefca0ceca7425c915efab66dd51f4e6843"}],"atlas_id":"pmmr-mucinous-colon","backbone_geometry":{"binder_chain_id":"A","binder_length":72,"contact_cutoff_angstrom":5.0,"contacted_orientation_hotspot_count":8,"contacted_orientation_hotspots":["B127","B129","B183","B218","B219","B220","B221","B316"],"contacted_reference_footprint":{"A":["A148","A149","A150","A178","A180","A212","A213","A214","A215","A218"],"B":["B126","B127","B129","B130","B170","B179","B180","B182","B183","B185","B217","B218","B219","B220","B221","B315","B316"]},"contacted_target_chains":["A","B"],"mapping_status":"ok","minimum_target_binder_distance_angstrom":1.4463,"source_to_output_chain":{"A":"B","B":"C"},"target_ca_rmsd_after_superposition_angstrom":0.0654},"binder_id":"rfd3-8tcg-04-mpnn-02","campaign_id":"8tcg-itgav-itgb6-geometry-recovery","candidate_id":"rfd3-8tcg-04-mpnn-02","claim_ceiling":"computational-design-hypothesis","cofold_observations":[{"artifacts":[{"bytes":464140,"role":"design-pose","sha256":"ec74e0ec5d12543c003a12e6aea24ae1f89e0983733c9d9cf9cc103875cc56a5"}],"chain_mapping":{"binder":"A","target":"C"},"environment_identity":null,"failure_code":"binder_lane_interface_scorer_adapter.py-exit-1","failure_reason":"binder_lane_interface_scorer_adapter.py exited 1","input_chain_mapping":null,"metrics":null,"model_revision":"boltz-2.2.1+cb04aeccdd480fd4db707f0bbafde538397fa2ac","package_version":null,"phase":"screen","predictor":"boltz2","provider_execution_identity_status":"not-recorded-on-failure","requested_seed":20260904,"seed":20260904,"source_revision":null,"status":"failed","tool_seed":20260904}],"evidence_class":"computational-design-hypothesis","lineage":{"backbone_artifact":{"bytes":113299,"sha256":"f2bb1aff2fc3bc70504ee2482924e66c578fb47fc87a66b2eaf02bbf3b26de74"},"materialized_design_pose":{"bytes":464140,"sha256":"ec74e0ec5d12543c003a12e6aea24ae1f89e0983733c9d9cf9cc103875cc56a5"},"materialized_sequence":{"bytes":95,"sha256":"a512fab88fb0a335800170682582cccf454e79072ea362fef0b273d4ae7575a7"},"parent_backbone_id":"rfd3-8tcg-04","proteinmpnn_fasta":{"bytes":555,"sha256":"ec8099b9a15359a9be24ea7fb4c28e2c3793c9efb9f15f2e00e298c0c06aadd2"},"proteinmpnn_record_ordinal":2,"proteinmpnn_requested_seed":202609044,"screen_candidate_manifest":{"bytes":20132,"root":"artifact-root","sha256":"f41b54c0de31a29eb328db414573506b2e16863250b8f7114784316acc449dc6"}},"molecular_format":"miniprotein","molecular_job":"block","opportunity_id":"O-ITGB6-8TCG-REFERENCE-RECOVERY","ranking_status":"unranked","sequence":"PSGSQVRGLAGKIARLIQEGVPREELVARLQASLGLSEAAARAAVDAIAAAAEKLDGVAAYHALVDAVRAER","sequence_design_metrics":{"T":0.1,"global_score":1.4824,"sample":2,"score":0.8207,"seq_recovery":0.4722},"sequence_length":72,"sequence_sha256":"cec344956dcfc2128db22d152ba1ef805b9710cc46741e2c782a1698aeefde20","target_id":"T-ENSG00000115221"},{"aggregate_metrics":{"failed_observation_count":0,"ipsae_min_median":0.0,"scored_observation_count":1,"target_contact_recall_median":0.0},"artifacts":[{"bytes":113455,"sha256":"127c0e98337ab2b92de8ac3acc4cc44352b004cfc68fdd3bb7442fced29da3b8"},{"bytes":555,"sha256":"b0d14b459383d419a705505990acfee033371d285d8142f2fbb63ec68342d0a3"},{"bytes":95,"sha256":"8673c29a5f79417b9643f87015f09ff4fd0cfe2180273bb33f06542a05f0638f"},{"bytes":465355,"sha256":"d28876a28ec92b6a4eb5adb6231d02bd1b24e729f04b4a09977f684c7f24a5bf"},{"bytes":57016,"sha256":"8c17db7d8f5fdeab63d29a244f232cefca0ceca7425c915efab66dd51f4e6843"}],"atlas_id":"pmmr-mucinous-colon","backbone_geometry":{"binder_chain_id":"A","binder_length":72,"contact_cutoff_angstrom":5.0,"contacted_orientation_hotspot_count":7,"contacted_orientation_hotspots":["B127","B129","B183","B219","B220","B221","B316"],"contacted_reference_footprint":{"A":["A150","A178","A212","A213","A214","A215","A218"],"B":["B126","B127","B129","B130","B183","B184","B185","B219","B220","B221","B316"]},"contacted_target_chains":["A","B"],"mapping_status":"ok","minimum_target_binder_distance_angstrom":1.5997,"source_to_output_chain":{"A":"B","B":"C"},"target_ca_rmsd_after_superposition_angstrom":0.0654},"binder_id":"rfd3-8tcg-05-mpnn-01","campaign_id":"8tcg-itgav-itgb6-geometry-recovery","candidate_id":"rfd3-8tcg-05-mpnn-01","claim_ceiling":"computational-design-hypothesis","cofold_observations":[{"artifacts":[{"bytes":458465,"role":"predicted-complex","sha256":"1cd5328262ef14cf51f802f0346dfeadfbd75b9d6d9365e94a501ab3bbf87439"},{"bytes":8031249,"role":"pae","sha256":"0e279cef74e0846ce74d169f7b42af1da4262ec7c13a17854345d87d534d5dab"},{"bytes":3197,"role":"metric-source","sha256":"8eea8cc7005d6f25681ee041f878ab02984318326a76729a2a1db732e9dbe08d"},{"bytes":465355,"role":"design-pose","sha256":"d28876a28ec92b6a4eb5adb6231d02bd1b24e729f04b4a09977f684c7f24a5bf"}],"chain_mapping":{"binder":"A","target":"C"},"environment_identity":"fal-boltz-v1:GPU-H100:1:python-3.12:boltz-2.2.1:torch-2.14.0+cu130","input_chain_mapping":{"A":"C","B":"B","C":"A"},"metrics":{"clash_count":0,"contact_count":16,"hotspot_recovery":0.0,"interface_pae":25.778672,"interface_plddt":77.683684,"ipsae_binder_to_target":0.0,"ipsae_min":0.0,"ipsae_target_to_binder":0.0,"iptm":0.864372,"mapping_status":"ok","sc_dockq":0.0289,"site_contact_iou":0.0,"target_alignment_rmsd":1.9644,"target_contact_precision":0.0,"target_contact_recall":0.0},"model_revision":"boltz-2.2.1+cb04aeccdd480fd4db707f0bbafde538397fa2ac","package_version":"2.2.1","phase":"screen","predictor":"boltz2","provider_execution_identity_status":"recorded","requested_seed":20260904,"seed":20260904,"source_revision":"boltz@cb04aeccdd480fd4db707f0bbafde538397fa2ac","status":"scored","tool_seed":20260904}],"evidence_class":"computational-design-hypothesis","lineage":{"backbone_artifact":{"bytes":113455,"sha256":"127c0e98337ab2b92de8ac3acc4cc44352b004cfc68fdd3bb7442fced29da3b8"},"materialized_design_pose":{"bytes":465355,"sha256":"d28876a28ec92b6a4eb5adb6231d02bd1b24e729f04b4a09977f684c7f24a5bf"},"materialized_sequence":{"bytes":95,"sha256":"8673c29a5f79417b9643f87015f09ff4fd0cfe2180273bb33f06542a05f0638f"},"parent_backbone_id":"rfd3-8tcg-05","proteinmpnn_fasta":{"bytes":555,"sha256":"b0d14b459383d419a705505990acfee033371d285d8142f2fbb63ec68342d0a3"},"proteinmpnn_record_ordinal":1,"proteinmpnn_requested_seed":202609045,"screen_candidate_manifest":{"bytes":20132,"root":"artifact-root","sha256":"f41b54c0de31a29eb328db414573506b2e16863250b8f7114784316acc449dc6"}},"molecular_format":"miniprotein","molecular_job":"block","opportunity_id":"O-ITGB6-8TCG-REFERENCE-RECOVERY","ranking_status":"unranked","sequence":"DPLSGAKAKAATLGVLAAVSEVTKETGVEVSEELKSELIKEAKAALEGKAVTAKEAFELAYEIAKKRLLEKV","sequence_design_metrics":{"T":0.1,"global_score":1.4636,"sample":1,"score":0.8564,"seq_recovery":0.5},"sequence_length":72,"sequence_sha256":"1ccb1539071c40ead49660f90176fa5b2da32e61ab3efc0ae8bfbe25adbe6477","target_id":"T-ENSG00000115221"},{"aggregate_metrics":{"failed_observation_count":0,"ipsae_min_median":0.391265,"scored_observation_count":1,"target_contact_recall_median":0.0},"artifacts":[{"bytes":113455,"sha256":"127c0e98337ab2b92de8ac3acc4cc44352b004cfc68fdd3bb7442fced29da3b8"},{"bytes":555,"sha256":"b0d14b459383d419a705505990acfee033371d285d8142f2fbb63ec68342d0a3"},{"bytes":95,"sha256":"28ef5bdb8544f74f536654d0da4b262b404ff051385cb61b420d786bf930887e"},{"bytes":465355,"sha256":"98e470b91491615ac88b319d77bd24a04e9038d961dfd98f3aa632214cf63b28"},{"bytes":57016,"sha256":"8c17db7d8f5fdeab63d29a244f232cefca0ceca7425c915efab66dd51f4e6843"}],"atlas_id":"pmmr-mucinous-colon","backbone_geometry":{"binder_chain_id":"A","binder_length":72,"contact_cutoff_angstrom":5.0,"contacted_orientation_hotspot_count":7,"contacted_orientation_hotspots":["B127","B129","B183","B219","B220","B221","B316"],"contacted_reference_footprint":{"A":["A150","A178","A212","A213","A214","A215","A218"],"B":["B126","B127","B129","B130","B183","B184","B185","B219","B220","B221","B316"]},"contacted_target_chains":["A","B"],"mapping_status":"ok","minimum_target_binder_distance_angstrom":1.5997,"source_to_output_chain":{"A":"B","B":"C"},"target_ca_rmsd_after_superposition_angstrom":0.0654},"binder_id":"rfd3-8tcg-05-mpnn-02","campaign_id":"8tcg-itgav-itgb6-geometry-recovery","candidate_id":"rfd3-8tcg-05-mpnn-02","claim_ceiling":"computational-design-hypothesis","cofold_observations":[{"artifacts":[{"bytes":459887,"role":"predicted-complex","sha256":"68ae05f1d671c215ba5a06f1495c9b96b3ab4f281ba69e480943ff30dae78347"},{"bytes":7955271,"role":"pae","sha256":"0f25ac9064cbf5a791eee4f0789b40abd55ce8e183ddabcf4378f72a51c095e4"},{"bytes":3212,"role":"metric-source","sha256":"472fd89b66be677c9ef85b930d4a78a3191d8d71d3942adfb185f81ceb540d59"},{"bytes":465355,"role":"design-pose","sha256":"98e470b91491615ac88b319d77bd24a04e9038d961dfd98f3aa632214cf63b28"}],"chain_mapping":{"binder":"A","target":"C"},"environment_identity":"fal-boltz-v1:GPU-H100:1:python-3.12:boltz-2.2.1:torch-2.14.0+cu130","input_chain_mapping":{"A":"C","B":"B","C":"A"},"metrics":{"clash_count":1,"contact_count":63,"hotspot_recovery":0.0,"interface_pae":7.142598,"interface_plddt":72.7106,"ipsae_binder_to_target":0.64216,"ipsae_min":0.391265,"ipsae_target_to_binder":0.391265,"iptm":0.950159,"mapping_status":"ok","sc_dockq":0.7337,"site_contact_iou":0.0,"target_alignment_rmsd":1.9363,"target_contact_precision":0.0,"target_contact_recall":0.0},"model_revision":"boltz-2.2.1+cb04aeccdd480fd4db707f0bbafde538397fa2ac","package_version":"2.2.1","phase":"screen","predictor":"boltz2","provider_execution_identity_status":"recorded","requested_seed":20260904,"seed":20260904,"source_revision":"boltz@cb04aeccdd480fd4db707f0bbafde538397fa2ac","status":"scored","tool_seed":20260904}],"evidence_class":"computational-design-hypothesis","lineage":{"backbone_artifact":{"bytes":113455,"sha256":"127c0e98337ab2b92de8ac3acc4cc44352b004cfc68fdd3bb7442fced29da3b8"},"materialized_design_pose":{"bytes":465355,"sha256":"98e470b91491615ac88b319d77bd24a04e9038d961dfd98f3aa632214cf63b28"},"materialized_sequence":{"bytes":95,"sha256":"28ef5bdb8544f74f536654d0da4b262b404ff051385cb61b420d786bf930887e"},"parent_backbone_id":"rfd3-8tcg-05","proteinmpnn_fasta":{"bytes":555,"sha256":"b0d14b459383d419a705505990acfee033371d285d8142f2fbb63ec68342d0a3"},"proteinmpnn_record_ordinal":2,"proteinmpnn_requested_seed":202609045,"screen_candidate_manifest":{"bytes":20132,"root":"artifact-root","sha256":"f41b54c0de31a29eb328db414573506b2e16863250b8f7114784316acc449dc6"}},"molecular_format":"miniprotein","molecular_job":"block","opportunity_id":"O-ITGB6-8TCG-REFERENCE-RECOVERY","ranking_status":"unranked","sequence":"APLSGAKRKAATLGVLAAVSEVEKETGVKVSEETRSELIKKAKEALKGKNVTNKEAFEIAYEIAYKELKEKV","sequence_design_metrics":{"T":0.1,"global_score":1.4465,"sample":2,"score":0.8752,"seq_recovery":0.4444},"sequence_length":72,"sequence_sha256":"5b4978736eae616531cb58e416c4cc09349291de733ed1f236212654d438fb47","target_id":"T-ENSG00000115221"},{"aggregate_metrics":{"failed_observation_count":0,"ipsae_min_median":0.0,"scored_observation_count":1,"target_contact_recall_median":0.0},"artifacts":[{"bytes":112930,"sha256":"9a710edbee01ad50a93d4119f4665463b9112d7215c89f11b186b409dfe4c2c4"},{"bytes":555,"sha256":"d54f412184e00aaf9bb970bf6c11fd6a285ccaa65eb431a39db87c0afc766cc2"},{"bytes":95,"sha256":"faa01a3246aeb94212bec8fc2b382b8006ee496ebb9a8b48f54a6ce3108d3f00"},{"bytes":463816,"sha256":"b5856818b5018895e931c11afb16c43a1910ebd220b5b19df3657352dd5c247e"},{"bytes":57016,"sha256":"8c17db7d8f5fdeab63d29a244f232cefca0ceca7425c915efab66dd51f4e6843"}],"atlas_id":"pmmr-mucinous-colon","backbone_geometry":{"binder_chain_id":"A","binder_length":72,"contact_cutoff_angstrom":5.0,"contacted_orientation_hotspot_count":5,"contacted_orientation_hotspots":["B127","B129","B183","B221","B316"],"contacted_reference_footprint":{"A":["A148","A150","A178","A212","A213","A214","A215","A218"],"B":["B126","B127","B129","B130","B180","B182","B183","B184","B185","B215","B221","B315","B316"]},"contacted_target_chains":["A","B"],"mapping_status":"ok","minimum_target_binder_distance_angstrom":1.8665,"source_to_output_chain":{"A":"B","B":"C"},"target_ca_rmsd_after_superposition_angstrom":0.0654},"binder_id":"rfd3-8tcg-06-mpnn-01","campaign_id":"8tcg-itgav-itgb6-geometry-recovery","candidate_id":"rfd3-8tcg-06-mpnn-01","claim_ceiling":"computational-design-hypothesis","cofold_observations":[{"artifacts":[{"bytes":460045,"role":"predicted-complex","sha256":"683f5d8576c1b30771efa798041a096c58ddd2b4805d199040294eae16355167"},{"bytes":8034212,"role":"pae","sha256":"b11f029073bad70d6b696d6cbf6367245771e6292b327dfe14c33af26329ef45"},{"bytes":3196,"role":"metric-source","sha256":"cb1b2e5cd19e38ec7e969346e77b1bb4a937a9276330be8c7956100ba2c93a1e"},{"bytes":463816,"role":"design-pose","sha256":"b5856818b5018895e931c11afb16c43a1910ebd220b5b19df3657352dd5c247e"}],"chain_mapping":{"binder":"A","target":"C"},"environment_identity":"fal-boltz-v1:GPU-H100:1:python-3.12:boltz-2.2.1:torch-2.14.0+cu130","input_chain_mapping":{"A":"C","B":"B","C":"A"},"metrics":{"clash_count":0,"contact_count":24,"hotspot_recovery":0.0,"interface_pae":27.063201,"interface_plddt":79.887826,"ipsae_binder_to_target":0.0,"ipsae_min":0.0,"ipsae_target_to_binder":0.0,"iptm":0.857469,"mapping_status":"ok","sc_dockq":0.0242,"site_contact_iou":0.0,"target_alignment_rmsd":1.9446,"target_contact_precision":0.0,"target_contact_recall":0.0},"model_revision":"boltz-2.2.1+cb04aeccdd480fd4db707f0bbafde538397fa2ac","package_version":"2.2.1","phase":"screen","predictor":"boltz2","provider_execution_identity_status":"recorded","requested_seed":20260904,"seed":20260904,"source_revision":"boltz@cb04aeccdd480fd4db707f0bbafde538397fa2ac","status":"scored","tool_seed":20260904}],"evidence_class":"computational-design-hypothesis","lineage":{"backbone_artifact":{"bytes":112930,"sha256":"9a710edbee01ad50a93d4119f4665463b9112d7215c89f11b186b409dfe4c2c4"},"materialized_design_pose":{"bytes":463816,"sha256":"b5856818b5018895e931c11afb16c43a1910ebd220b5b19df3657352dd5c247e"},"materialized_sequence":{"bytes":95,"sha256":"faa01a3246aeb94212bec8fc2b382b8006ee496ebb9a8b48f54a6ce3108d3f00"},"parent_backbone_id":"rfd3-8tcg-06","proteinmpnn_fasta":{"bytes":555,"sha256":"d54f412184e00aaf9bb970bf6c11fd6a285ccaa65eb431a39db87c0afc766cc2"},"proteinmpnn_record_ordinal":1,"proteinmpnn_requested_seed":202609046,"screen_candidate_manifest":{"bytes":20132,"root":"artifact-root","sha256":"f41b54c0de31a29eb328db414573506b2e16863250b8f7114784316acc449dc6"}},"molecular_format":"miniprotein","molecular_job":"block","opportunity_id":"O-ITGB6-8TCG-REFERENCE-RECOVERY","ranking_status":"unranked","sequence":"EKKEKAKELIEEAVRLAKEGKVKEALEKVKEATELADNNPEVALLAYTAVRDAAAGLTDDAERAKKKAVELI","sequence_design_metrics":{"T":0.1,"global_score":1.4821,"sample":1,"score":0.9324,"seq_recovery":0.4028},"sequence_length":72,"sequence_sha256":"cb47f3ec535b9a14646ee134ca338f6b19b05707e9f3b1257567be4efc55170d","target_id":"T-ENSG00000115221"},{"aggregate_metrics":{"failed_observation_count":0,"ipsae_min_median":0.0,"scored_observation_count":1,"target_contact_recall_median":0.0},"artifacts":[{"bytes":112930,"sha256":"9a710edbee01ad50a93d4119f4665463b9112d7215c89f11b186b409dfe4c2c4"},{"bytes":555,"sha256":"d54f412184e00aaf9bb970bf6c11fd6a285ccaa65eb431a39db87c0afc766cc2"},{"bytes":95,"sha256":"3a208cb780a8f2d39e2517e44633d46e91901bc85cdd62106afb7487f601f915"},{"bytes":463816,"sha256":"c86552e7ddf381ea58dd8c0a764384bfe7b4e915df08109b41c1239f7d96edcb"},{"bytes":57016,"sha256":"8c17db7d8f5fdeab63d29a244f232cefca0ceca7425c915efab66dd51f4e6843"}],"atlas_id":"pmmr-mucinous-colon","backbone_geometry":{"binder_chain_id":"A","binder_length":72,"contact_cutoff_angstrom":5.0,"contacted_orientation_hotspot_count":5,"contacted_orientation_hotspots":["B127","B129","B183","B221","B316"],"contacted_reference_footprint":{"A":["A148","A150","A178","A212","A213","A214","A215","A218"],"B":["B126","B127","B129","B130","B180","B182","B183","B184","B185","B215","B221","B315","B316"]},"contacted_target_chains":["A","B"],"mapping_status":"ok","minimum_target_binder_distance_angstrom":1.8665,"source_to_output_chain":{"A":"B","B":"C"},"target_ca_rmsd_after_superposition_angstrom":0.0654},"binder_id":"rfd3-8tcg-06-mpnn-02","campaign_id":"8tcg-itgav-itgb6-geometry-recovery","candidate_id":"rfd3-8tcg-06-mpnn-02","claim_ceiling":"computational-design-hypothesis","cofold_observations":[{"artifacts":[{"bytes":459176,"role":"predicted-complex","sha256":"fca3189d6aca63122434ed45e762e39ae88d24639ec4b3a9df901a1d44f1edc4"},{"bytes":8034839,"role":"pae","sha256":"98455d2b0e645c2d88d7fb2972f0d66a9f98268ad1eefd567d5da95e27f21885"},{"bytes":3199,"role":"metric-source","sha256":"9042654be65759ddd869488aa72c4896e5ce620ddda8de2bd910f2c38f63b41b"},{"bytes":463816,"role":"design-pose","sha256":"c86552e7ddf381ea58dd8c0a764384bfe7b4e915df08109b41c1239f7d96edcb"}],"chain_mapping":{"binder":"A","target":"C"},"environment_identity":"fal-boltz-v1:GPU-H100:1:python-3.12:boltz-2.2.1:torch-2.14.0+cu130","input_chain_mapping":{"A":"C","B":"B","C":"A"},"metrics":{"clash_count":0,"contact_count":21,"hotspot_recovery":0.0,"interface_pae":23.168568,"interface_plddt":81.268261,"ipsae_binder_to_target":0.0,"ipsae_min":0.0,"ipsae_target_to_binder":0.0,"iptm":0.870563,"mapping_status":"ok","sc_dockq":0.0265,"site_contact_iou":0.0,"target_alignment_rmsd":1.8894,"target_contact_precision":0.0,"target_contact_recall":0.0},"model_revision":"boltz-2.2.1+cb04aeccdd480fd4db707f0bbafde538397fa2ac","package_version":"2.2.1","phase":"screen","predictor":"boltz2","provider_execution_identity_status":"recorded","requested_seed":20260904,"seed":20260904,"source_revision":"boltz@cb04aeccdd480fd4db707f0bbafde538397fa2ac","status":"scored","tool_seed":20260904}],"evidence_class":"computational-design-hypothesis","lineage":{"backbone_artifact":{"bytes":112930,"sha256":"9a710edbee01ad50a93d4119f4665463b9112d7215c89f11b186b409dfe4c2c4"},"materialized_design_pose":{"bytes":463816,"sha256":"c86552e7ddf381ea58dd8c0a764384bfe7b4e915df08109b41c1239f7d96edcb"},"materialized_sequence":{"bytes":95,"sha256":"3a208cb780a8f2d39e2517e44633d46e91901bc85cdd62106afb7487f601f915"},"parent_backbone_id":"rfd3-8tcg-06","proteinmpnn_fasta":{"bytes":555,"sha256":"d54f412184e00aaf9bb970bf6c11fd6a285ccaa65eb431a39db87c0afc766cc2"},"proteinmpnn_record_ordinal":2,"proteinmpnn_requested_seed":202609046,"screen_candidate_manifest":{"bytes":20132,"root":"artifact-root","sha256":"f41b54c0de31a29eb328db414573506b2e16863250b8f7114784316acc449dc6"}},"molecular_format":"miniprotein","molecular_job":"block","opportunity_id":"O-ITGB6-8TCG-REFERENCE-RECOVERY","ranking_status":"unranked","sequence":"EKKEKAIKLVEEAVELAARGEVKKARELVKKATELANNNPEFALLADSAVRDAAAGDFDDAARAAKKAAELL","sequence_design_metrics":{"T":0.1,"global_score":1.475,"sample":2,"score":0.9523,"seq_recovery":0.4167},"sequence_length":72,"sequence_sha256":"a1f6900b1592b0936cb45d9d2f5cf05aba24d457f04ec1980617998566a88467","target_id":"T-ENSG00000115221"},{"aggregate_metrics":{"failed_observation_count":0,"ipsae_min_median":0.0,"scored_observation_count":1,"target_contact_recall_median":0.0},"artifacts":[{"bytes":114617,"sha256":"e2393bd9c3af5b3452f8773b44ee044363095caac3c41fe2e237997766f32309"},{"bytes":555,"sha256":"92443b54ff997d84ca95383e997ae534781dbd569dcbdbed0a15f9c205fc2345"},{"bytes":95,"sha256":"4413cde7a718046d9e98b80ee6bb03e28e0c5893cffb96fe0a94510d01331dab"},{"bytes":467947,"sha256":"15611f47a2f4723c5702a7d7aa56a714afb52c51e94e8da542cdd69a9a400a56"},{"bytes":57016,"sha256":"8c17db7d8f5fdeab63d29a244f232cefca0ceca7425c915efab66dd51f4e6843"}],"atlas_id":"pmmr-mucinous-colon","backbone_geometry":{"binder_chain_id":"A","binder_length":72,"contact_cutoff_angstrom":5.0,"contacted_orientation_hotspot_count":5,"contacted_orientation_hotspots":["B127","B129","B183","B221","B316"],"contacted_reference_footprint":{"A":["A148","A150","A178","A212","A213","A214","A215","A218"],"B":["B126","B127","B129","B130","B182","B183","B184","B185","B221","B315","B316"]},"contacted_target_chains":["A","B"],"mapping_status":"ok","minimum_target_binder_distance_angstrom":1.8976,"source_to_output_chain":{"A":"B","B":"C"},"target_ca_rmsd_after_superposition_angstrom":0.0654},"binder_id":"rfd3-8tcg-07-mpnn-01","campaign_id":"8tcg-itgav-itgb6-geometry-recovery","candidate_id":"rfd3-8tcg-07-mpnn-01","claim_ceiling":"computational-design-hypothesis","cofold_observations":[{"artifacts":[{"bytes":463047,"role":"predicted-complex","sha256":"a463b5290270c1cb27361a3523956eeb5b37a1c064ce9287d43fa54bf602e0a1"},{"bytes":8043464,"role":"pae","sha256":"a839d57ccb254fc017c888a054c9b749b2565e4aba257343c612836525d43d08"},{"bytes":3199,"role":"metric-source","sha256":"0fb84391de488d01fd607e068d6ba03cd4d1ffb7ef44cef2df48bde87352bf88"},{"bytes":467947,"role":"design-pose","sha256":"15611f47a2f4723c5702a7d7aa56a714afb52c51e94e8da542cdd69a9a400a56"}],"chain_mapping":{"binder":"A","target":"C"},"environment_identity":"fal-boltz-v1:GPU-H100:1:python-3.12:boltz-2.2.1:torch-2.14.0+cu130","input_chain_mapping":{"A":"C","B":"B","C":"A"},"metrics":{"clash_count":0,"contact_count":37,"hotspot_recovery":0.0,"interface_pae":27.252097,"interface_plddt":79.880625,"ipsae_binder_to_target":0.0,"ipsae_min":0.0,"ipsae_target_to_binder":0.0,"iptm":0.850049,"mapping_status":"ok","sc_dockq":0.0297,"site_contact_iou":0.0,"target_alignment_rmsd":1.9517,"target_contact_precision":0.0,"target_contact_recall":0.0},"model_revision":"boltz-2.2.1+cb04aeccdd480fd4db707f0bbafde538397fa2ac","package_version":"2.2.1","phase":"screen","predictor":"boltz2","provider_execution_identity_status":"recorded","requested_seed":20260904,"seed":20260904,"source_revision":"boltz@cb04aeccdd480fd4db707f0bbafde538397fa2ac","status":"scored","tool_seed":20260904}],"evidence_class":"computational-design-hypothesis","lineage":{"backbone_artifact":{"bytes":114617,"sha256":"e2393bd9c3af5b3452f8773b44ee044363095caac3c41fe2e237997766f32309"},"materialized_design_pose":{"bytes":467947,"sha256":"15611f47a2f4723c5702a7d7aa56a714afb52c51e94e8da542cdd69a9a400a56"},"materialized_sequence":{"bytes":95,"sha256":"4413cde7a718046d9e98b80ee6bb03e28e0c5893cffb96fe0a94510d01331dab"},"parent_backbone_id":"rfd3-8tcg-07","proteinmpnn_fasta":{"bytes":555,"sha256":"92443b54ff997d84ca95383e997ae534781dbd569dcbdbed0a15f9c205fc2345"},"proteinmpnn_record_ordinal":1,"proteinmpnn_requested_seed":202609047,"screen_candidate_manifest":{"bytes":20132,"root":"artifact-root","sha256":"f41b54c0de31a29eb328db414573506b2e16863250b8f7114784316acc449dc6"}},"molecular_format":"miniprotein","molecular_job":"block","opportunity_id":"O-ITGB6-8TCG-REFERENCE-RECOVERY","ranking_status":"unranked","sequence":"AEEKIKADPNNSNAWYTLGLEYYAKGNYKEAAEYFEKALAIDPRYVKAHTMLSRVYKKLGNKEKADEIAEKR","sequence_design_metrics":{"T":0.1,"global_score":1.4845,"sample":1,"score":0.9106,"seq_recovery":0.375},"sequence_length":72,"sequence_sha256":"e577fe6e124d9ea82a08aa1697065ccbdd7ee29abe04dd1c29e1cbfb77468ad6","target_id":"T-ENSG00000115221"},{"aggregate_metrics":{"failed_observation_count":1,"ipsae_min_median":null,"scored_observation_count":0,"target_contact_recall_median":null},"artifacts":[{"bytes":114617,"sha256":"e2393bd9c3af5b3452f8773b44ee044363095caac3c41fe2e237997766f32309"},{"bytes":555,"sha256":"92443b54ff997d84ca95383e997ae534781dbd569dcbdbed0a15f9c205fc2345"},{"bytes":95,"sha256":"be8c17c01c5f0485c656a824c5f8e4cce8138b1ca1c459349916ccbb44d030d9"},{"bytes":467947,"sha256":"b18dabc2af9e097e914519a11b1e324a47ed8218a0507a441f5a2725d1d084cb"},{"bytes":57016,"sha256":"8c17db7d8f5fdeab63d29a244f232cefca0ceca7425c915efab66dd51f4e6843"}],"atlas_id":"pmmr-mucinous-colon","backbone_geometry":{"binder_chain_id":"A","binder_length":72,"contact_cutoff_angstrom":5.0,"contacted_orientation_hotspot_count":5,"contacted_orientation_hotspots":["B127","B129","B183","B221","B316"],"contacted_reference_footprint":{"A":["A148","A150","A178","A212","A213","A214","A215","A218"],"B":["B126","B127","B129","B130","B182","B183","B184","B185","B221","B315","B316"]},"contacted_target_chains":["A","B"],"mapping_status":"ok","minimum_target_binder_distance_angstrom":1.8976,"source_to_output_chain":{"A":"B","B":"C"},"target_ca_rmsd_after_superposition_angstrom":0.0654},"binder_id":"rfd3-8tcg-07-mpnn-02","campaign_id":"8tcg-itgav-itgb6-geometry-recovery","candidate_id":"rfd3-8tcg-07-mpnn-02","claim_ceiling":"computational-design-hypothesis","cofold_observations":[{"artifacts":[{"bytes":467947,"role":"design-pose","sha256":"b18dabc2af9e097e914519a11b1e324a47ed8218a0507a441f5a2725d1d084cb"}],"chain_mapping":{"binder":"A","target":"C"},"environment_identity":null,"failure_code":"binder_lane_interface_scorer_adapter.py-exit-1","failure_reason":"binder_lane_interface_scorer_adapter.py exited 1","input_chain_mapping":null,"metrics":null,"model_revision":"boltz-2.2.1+cb04aeccdd480fd4db707f0bbafde538397fa2ac","package_version":null,"phase":"screen","predictor":"boltz2","provider_execution_identity_status":"not-recorded-on-failure","requested_seed":20260904,"seed":20260904,"source_revision":null,"status":"failed","tool_seed":20260904}],"evidence_class":"computational-design-hypothesis","lineage":{"backbone_artifact":{"bytes":114617,"sha256":"e2393bd9c3af5b3452f8773b44ee044363095caac3c41fe2e237997766f32309"},"materialized_design_pose":{"bytes":467947,"sha256":"b18dabc2af9e097e914519a11b1e324a47ed8218a0507a441f5a2725d1d084cb"},"materialized_sequence":{"bytes":95,"sha256":"be8c17c01c5f0485c656a824c5f8e4cce8138b1ca1c459349916ccbb44d030d9"},"parent_backbone_id":"rfd3-8tcg-07","proteinmpnn_fasta":{"bytes":555,"sha256":"92443b54ff997d84ca95383e997ae534781dbd569dcbdbed0a15f9c205fc2345"},"proteinmpnn_record_ordinal":2,"proteinmpnn_requested_seed":202609047,"screen_candidate_manifest":{"bytes":20132,"root":"artifact-root","sha256":"f41b54c0de31a29eb328db414573506b2e16863250b8f7114784316acc449dc6"}},"molecular_format":"miniprotein","molecular_job":"block","opportunity_id":"O-ITGB6-8TCG-REFERENCE-RECOVERY","ranking_status":"unranked","sequence":"YQAKIAADPNNSRAWYALGKEYFAKGDYKNAAAAFEKAIAIDPTFVQAHTYLSRVYNKLGDKAKADAVAEKR","sequence_design_metrics":{"T":0.1,"global_score":1.4565,"sample":2,"score":0.8906,"seq_recovery":0.4444},"sequence_length":72,"sequence_sha256":"e8fe75b974fcb1a7960bbda997be17bf001cd1ad0da6d55b847e74446dd770bb","target_id":"T-ENSG00000115221"},{"aggregate_metrics":{"failed_observation_count":0,"ipsae_min_median":0.0,"scored_observation_count":1,"target_contact_recall_median":0.0},"artifacts":[{"bytes":113523,"sha256":"82e4866e3498b01f245e611e0408b1a797478a1ba4efd1c79707fafde5dededb"},{"bytes":555,"sha256":"976ab06be32e7e4a628c6607a25b90c1e10bbc5f68aae30e4c3ab9c2b6fd3366"},{"bytes":95,"sha256":"3803d3866f87311f562955503e7003d0b9dcf9875ce620daa54567606f9ad6ec"},{"bytes":465922,"sha256":"44eb5c1734cd8515d87fcfa365b7df3da1ba45e7d45c12e8fff99799c924e2d5"},{"bytes":57016,"sha256":"8c17db7d8f5fdeab63d29a244f232cefca0ceca7425c915efab66dd51f4e6843"}],"atlas_id":"pmmr-mucinous-colon","backbone_geometry":{"binder_chain_id":"A","binder_length":72,"contact_cutoff_angstrom":5.0,"contacted_orientation_hotspot_count":8,"contacted_orientation_hotspots":["B127","B129","B183","B218","B219","B220","B221","B316"],"contacted_reference_footprint":{"A":["A150","A177","A178","A180","A212","A213","A214","A215","A218"],"B":["B126","B127","B129","B130","B179","B180","B182","B183","B184","B185","B217","B218","B219","B220","B221","B316"]},"contacted_target_chains":["A","B"],"mapping_status":"ok","minimum_target_binder_distance_angstrom":1.6036,"source_to_output_chain":{"A":"B","B":"C"},"target_ca_rmsd_after_superposition_angstrom":0.0654},"binder_id":"rfd3-8tcg-08-mpnn-01","campaign_id":"8tcg-itgav-itgb6-geometry-recovery","candidate_id":"rfd3-8tcg-08-mpnn-01","claim_ceiling":"computational-design-hypothesis","cofold_observations":[{"artifacts":[{"bytes":459492,"role":"predicted-complex","sha256":"c4b6270945194509ffae8a330af1b0494fe990590942af75e887cf212a108028"},{"bytes":8046945,"role":"pae","sha256":"492fe889722f85ddcbeab2d2495105b565caabd9cd6375af9b98162986775596"},{"bytes":3197,"role":"metric-source","sha256":"c9d358a8c7434caf68df4b1ce239135bf565acf1845579c5806c7b37f3893217"},{"bytes":465922,"role":"design-pose","sha256":"44eb5c1734cd8515d87fcfa365b7df3da1ba45e7d45c12e8fff99799c924e2d5"}],"chain_mapping":{"binder":"A","target":"C"},"environment_identity":"fal-boltz-v1:GPU-H100:1:python-3.12:boltz-2.2.1:torch-2.14.0+cu130","input_chain_mapping":{"A":"C","B":"B","C":"A"},"metrics":{"clash_count":2,"contact_count":20,"hotspot_recovery":0.0,"interface_pae":20.799912,"interface_plddt":81.132632,"ipsae_binder_to_target":0.0,"ipsae_min":0.0,"ipsae_target_to_binder":0.0,"iptm":0.880246,"mapping_status":"ok","sc_dockq":0.2159,"site_contact_iou":0.0,"target_alignment_rmsd":0.7049,"target_contact_precision":0.0,"target_contact_recall":0.0},"model_revision":"boltz-2.2.1+cb04aeccdd480fd4db707f0bbafde538397fa2ac","package_version":"2.2.1","phase":"screen","predictor":"boltz2","provider_execution_identity_status":"recorded","requested_seed":20260904,"seed":20260904,"source_revision":"boltz@cb04aeccdd480fd4db707f0bbafde538397fa2ac","status":"scored","tool_seed":20260904}],"evidence_class":"computational-design-hypothesis","lineage":{"backbone_artifact":{"bytes":113523,"sha256":"82e4866e3498b01f245e611e0408b1a797478a1ba4efd1c79707fafde5dededb"},"materialized_design_pose":{"bytes":465922,"sha256":"44eb5c1734cd8515d87fcfa365b7df3da1ba45e7d45c12e8fff99799c924e2d5"},"materialized_sequence":{"bytes":95,"sha256":"3803d3866f87311f562955503e7003d0b9dcf9875ce620daa54567606f9ad6ec"},"parent_backbone_id":"rfd3-8tcg-08","proteinmpnn_fasta":{"bytes":555,"sha256":"976ab06be32e7e4a628c6607a25b90c1e10bbc5f68aae30e4c3ab9c2b6fd3366"},"proteinmpnn_record_ordinal":1,"proteinmpnn_requested_seed":202609048,"screen_candidate_manifest":{"bytes":20132,"root":"artifact-root","sha256":"f41b54c0de31a29eb328db414573506b2e16863250b8f7114784316acc449dc6"}},"molecular_format":"miniprotein","molecular_job":"block","opportunity_id":"O-ITGB6-8TCG-REFERENCE-RECOVERY","ranking_status":"unranked","sequence":"KIEEAIKAAEEGNLEKAIKLAKEAAKLARSNMETVKYLGSAIKAAKEGNLEKAIESLKKALEIAKKRGLEEA","sequence_design_metrics":{"T":0.1,"global_score":1.4701,"sample":1,"score":0.7257,"seq_recovery":0.4444},"sequence_length":72,"sequence_sha256":"dfe5cba3f2b978c4735e61f80c7638af998c99d2fa17cb227faee0a781b6254c","target_id":"T-ENSG00000115221"},{"aggregate_metrics":{"failed_observation_count":0,"ipsae_min_median":0.0,"scored_observation_count":1,"target_contact_recall_median":0.0},"artifacts":[{"bytes":113523,"sha256":"82e4866e3498b01f245e611e0408b1a797478a1ba4efd1c79707fafde5dededb"},{"bytes":555,"sha256":"976ab06be32e7e4a628c6607a25b90c1e10bbc5f68aae30e4c3ab9c2b6fd3366"},{"bytes":95,"sha256":"492ce758bb9b74e4ca49c6c0a3180ffa6d2ab90edd0120335f5682cf89136b80"},{"bytes":465922,"sha256":"9e8061ff322fd8cf726a7bfe00a7752f9c765e38b2abc3f2193ac1b7b6efe107"},{"bytes":57016,"sha256":"8c17db7d8f5fdeab63d29a244f232cefca0ceca7425c915efab66dd51f4e6843"}],"atlas_id":"pmmr-mucinous-colon","backbone_geometry":{"binder_chain_id":"A","binder_length":72,"contact_cutoff_angstrom":5.0,"contacted_orientation_hotspot_count":8,"contacted_orientation_hotspots":["B127","B129","B183","B218","B219","B220","B221","B316"],"contacted_reference_footprint":{"A":["A150","A177","A178","A180","A212","A213","A214","A215","A218"],"B":["B126","B127","B129","B130","B179","B180","B182","B183","B184","B185","B217","B218","B219","B220","B221","B316"]},"contacted_target_chains":["A","B"],"mapping_status":"ok","minimum_target_binder_distance_angstrom":1.6036,"source_to_output_chain":{"A":"B","B":"C"},"target_ca_rmsd_after_superposition_angstrom":0.0654},"binder_id":"rfd3-8tcg-08-mpnn-02","campaign_id":"8tcg-itgav-itgb6-geometry-recovery","candidate_id":"rfd3-8tcg-08-mpnn-02","claim_ceiling":"computational-design-hypothesis","cofold_observations":[{"artifacts":[{"bytes":456885,"role":"predicted-complex","sha256":"0cca5a3bccfa3437e8d2bc2a928456daafd8254e9f50995522805ca826c202f4"},{"bytes":8038248,"role":"pae","sha256":"1d3fd18d0a722e3669df931926bcb9b060b005c0437d8ba32c929fc7f3818b5e"},{"bytes":3197,"role":"metric-source","sha256":"0967f83f69af2e858a1a1536337af43a506ae12d4b8825c9687e3ea8abc7ad4b"},{"bytes":465922,"role":"design-pose","sha256":"9e8061ff322fd8cf726a7bfe00a7752f9c765e38b2abc3f2193ac1b7b6efe107"}],"chain_mapping":{"binder":"A","target":"C"},"environment_identity":"fal-boltz-v1:GPU-H100:1:python-3.12:boltz-2.2.1:torch-2.14.0+cu130","input_chain_mapping":{"A":"C","B":"B","C":"A"},"metrics":{"clash_count":0,"contact_count":17,"hotspot_recovery":0.0,"interface_pae":20.868679,"interface_plddt":82.005789,"ipsae_binder_to_target":0.0,"ipsae_min":0.0,"ipsae_target_to_binder":0.0,"iptm":0.881411,"mapping_status":"ok","sc_dockq":0.0372,"site_contact_iou":0.0,"target_alignment_rmsd":1.9594,"target_contact_precision":0.0,"target_contact_recall":0.0},"model_revision":"boltz-2.2.1+cb04aeccdd480fd4db707f0bbafde538397fa2ac","package_version":"2.2.1","phase":"screen","predictor":"boltz2","provider_execution_identity_status":"recorded","requested_seed":20260904,"seed":20260904,"source_revision":"boltz@cb04aeccdd480fd4db707f0bbafde538397fa2ac","status":"scored","tool_seed":20260904}],"evidence_class":"computational-design-hypothesis","lineage":{"backbone_artifact":{"bytes":113523,"sha256":"82e4866e3498b01f245e611e0408b1a797478a1ba4efd1c79707fafde5dededb"},"materialized_design_pose":{"bytes":465922,"sha256":"9e8061ff322fd8cf726a7bfe00a7752f9c765e38b2abc3f2193ac1b7b6efe107"},"materialized_sequence":{"bytes":95,"sha256":"492ce758bb9b74e4ca49c6c0a3180ffa6d2ab90edd0120335f5682cf89136b80"},"parent_backbone_id":"rfd3-8tcg-08","proteinmpnn_fasta":{"bytes":555,"sha256":"976ab06be32e7e4a628c6607a25b90c1e10bbc5f68aae30e4c3ab9c2b6fd3366"},"proteinmpnn_record_ordinal":2,"proteinmpnn_requested_seed":202609048,"screen_candidate_manifest":{"bytes":20132,"root":"artifact-root","sha256":"f41b54c0de31a29eb328db414573506b2e16863250b8f7114784316acc449dc6"}},"molecular_format":"miniprotein","molecular_job":"block","opportunity_id":"O-ITGB6-8TCG-REFERENCE-RECOVERY","ranking_status":"unranked","sequence":"LIQKAIDAAKAGDLDKAIALLKEAAKKARGNQETVKWIGAAIEAAKAGDLDGAIAAAEKALENAKKAGDTEA","sequence_design_metrics":{"T":0.1,"global_score":1.4728,"sample":2,"score":0.8122,"seq_recovery":0.5972},"sequence_length":72,"sequence_sha256":"07a90ff3cf2918ee73ce14bd3f15135fc4d2716bb59486299d10aa02b3aad399","target_id":"T-ENSG00000115221"}],"routes":[{"checkpoint":"rfd3_foundry_2025_12_01_remapped.ckpt","checkpoint_sha256":"9b3f85923e0d51e9453e15cdd2f8c666e7ce096a60577f57d11bbc54ae6d67c1","environment":"main","hardware":"GPU-H100","model":"RFdiffusion3","provider":"fal","route_role":"locked-plan-route","stage":"backbone-generation"},{"checkpoint":"vanilla_model_weights/v_48_020.pt","checkpoint_sha256":"c9cb4a671d79604111231f8dbfc7c590e06f1197453b7a6854ac6661a642f5bd","environment":"main","hardware":"M","model":"ProteinMPNN","provider":"fal","route_role":"locked-plan-route","stage":"sequence-design"},{"environment":"main","hardware":"GPU-H100","model":"Boltz-2","package_version":"2.2.1","provider":"fal","route_role":"locked-plan-route","source_revision":"cb04aeccdd480fd4db707f0bbafde538397fa2ac","stage":"complex-validation"}],"schema_version":"codex-surface-binder-result-collection/v0.1","source_documents":{"canary_plan":{"bytes":17830,"sha256":"e17ce8cd273a749c4b44e0d2e3a62e83b3d56b8e8f4c2df713b6666768df49a7"},"candidate_manifest":{"bytes":20132,"root":"artifact-root","sha256":"f41b54c0de31a29eb328db414573506b2e16863250b8f7114784316acc449dc6"}},"stage_states":{"backbone_generation":"completed","complex_validation":"partial","sequence_design":"completed"},"target_id":"T-ENSG00000115221"},"stage_states":{"backbone_generation":"completed","complex_validation":"partial","sequence_design":"completed"},"target_id":"T-ENSG00000115221"}]}