{"atlas_id":"pmmr-mucinous-colon","claim_ceiling":"bounded measured and curated database evidence at protein-target level; no record is promoted to deposited extracellular-site binding, therapeutic action, selectivity, normal-tissue safety, or efficacy without separate evidence","counts":{"cache_reused":73,"interactions":57,"interactions_by_source":{"BindingDB":26,"ChEMBL":31},"pdb_accessions_queried":12,"queries":73,"query_statuses":{"complete":65,"failed":8},"site_relevance_states":{"pdb-indexed-target-match-not-site-localized":15,"target-level-not-site-localized":42},"structure_a_targets":10,"unresolved":8},"created_at":"2026-09-05","evidence_partition":{"computational_hypotheses":"screening-results.json","curated_intervention_relationships":"interventions.json","deposited_structure_relationships":"actionable-sites.json","this_collection":"measured-binding-database-record"},"queries":[{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-target-resolution","query_id":"CH-TARGET-P00533","raw_artifact":{"bytes":67992,"format":"json","sha256":"7537f4e48dcb594dcf343f622ffd987a684ec063d9f28eb405491348faed90e5","storage":"external-artifact-root"},"response_counts":{"helper_available":1,"helper_returned":1,"helper_truncated":false,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000146648"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-target-resolution","query_id":"CH-TARGET-P04626","raw_artifact":{"bytes":25396,"format":"json","sha256":"8976ada5102d81e67e6272e842c9357064db2badec0a03291e003cce008a0dd9","storage":"external-artifact-root"},"response_counts":{"helper_available":1,"helper_returned":1,"helper_truncated":false,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000141736"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-target-resolution","query_id":"CH-TARGET-P06731","raw_artifact":{"bytes":5883,"format":"json","sha256":"cf6f657c735acdb5bbcb096a3455c2eaaa7e4586ecc74a336c7974b8b7f5e942","storage":"external-artifact-root"},"response_counts":{"helper_available":1,"helper_returned":1,"helper_truncated":false,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000105388"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-target-resolution","query_id":"CH-TARGET-P08581","raw_artifact":{"bytes":28282,"format":"json","sha256":"d121dc8374d118f3db2b3f246ceab1642f6876c7e09d4010b4180d020c69055b","storage":"external-artifact-root"},"response_counts":{"helper_available":1,"helper_returned":1,"helper_truncated":false,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000105976"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-target-resolution","query_id":"CH-TARGET-P09758","raw_artifact":{"bytes":5554,"format":"json","sha256":"259f8b65bc36c40a60b440e680db4baa6eec8af5db258d64d8e5312b7672302b","storage":"external-artifact-root"},"response_counts":{"helper_available":1,"helper_returned":1,"helper_truncated":false,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000184292"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-target-resolution","query_id":"CH-TARGET-P16422","raw_artifact":{"bytes":6627,"format":"json","sha256":"748e513721c21767fd66a1cff313a3d5255dddc88eebc8a949c4adcc15d5f463","storage":"external-artifact-root"},"response_counts":{"helper_available":1,"helper_returned":1,"helper_truncated":false,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000119888"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-target-resolution","query_id":"CH-TARGET-P21589","raw_artifact":{"bytes":12008,"format":"json","sha256":"d572c403b40e4dfb6debf834af4852aebe4bacc693bd7958e2f7131dba0a4129","storage":"external-artifact-root"},"response_counts":{"helper_available":1,"helper_returned":1,"helper_truncated":false,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000135318"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-target-resolution","query_id":"CH-TARGET-P25092","raw_artifact":{"bytes":4983,"format":"json","sha256":"1e1bf81d91e86a7d56116ee26f6a412773f8894fa6500cc02de840f4c95eb5d8","storage":"external-artifact-root"},"response_counts":{"helper_available":1,"helper_returned":1,"helper_truncated":false,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000070019"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-target-resolution","query_id":"CH-TARGET-Q08722","raw_artifact":{"bytes":8480,"format":"json","sha256":"bf21d45c04bc11f70dd54763641c17e90c0697b41308871fbf41904cb7db386b","storage":"external-artifact-root"},"response_counts":{"helper_available":1,"helper_returned":1,"helper_truncated":false,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000196776"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-target-resolution","query_id":"CH-TARGET-Q12884","raw_artifact":{"bytes":7787,"format":"json","sha256":"1b0a58d8630b1de4587bb3e768b4058ca77d423f1bab752dcd39d7d24a390e51","storage":"external-artifact-root"},"response_counts":{"helper_available":1,"helper_returned":1,"helper_truncated":false,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000078098"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-activity","query_id":"CH-ACT-CHEMBL1795197","raw_artifact":{"bytes":109,"format":"json","sha256":"f95bb82987285813aadf8d59d1b3533323a27896c88d7a5375d195e8058fc1d7","storage":"external-artifact-root"},"response_counts":{"helper_available":0,"helper_returned":0,"helper_truncated":false,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000070019"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-activity","query_id":"CH-ACT-CHEMBL1824","raw_artifact":{"bytes":46117,"format":"json","sha256":"c8317247dd8bb932a0a51db1f4d741c0a986001a77cbff68b95cefed1e1fb24f","storage":"external-artifact-root"},"response_counts":{"helper_available":20,"helper_returned":20,"helper_truncated":false,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000141736"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-activity","query_id":"CH-ACT-CHEMBL203","raw_artifact":{"bytes":38676,"format":"json","sha256":"ba6284409485539dca98b8f6f2182300e1e26d85dc845621fab2cacfa90b1d16","storage":"external-artifact-root"},"response_counts":{"helper_available":20,"helper_returned":20,"helper_truncated":false,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000146648"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-activity","query_id":"CH-ACT-CHEMBL3580493","raw_artifact":{"bytes":4058,"format":"json","sha256":"271a57650306d680f09ab958488b1713c05f99a51bbcfd26cb5c6ffefe33ce2d","storage":"external-artifact-root"},"response_counts":{"helper_available":2,"helper_returned":2,"helper_truncated":false,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000119888"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-activity","query_id":"CH-ACT-CHEMBL3712881","raw_artifact":{"bytes":109,"format":"json","sha256":"f95bb82987285813aadf8d59d1b3533323a27896c88d7a5375d195e8058fc1d7","storage":"external-artifact-root"},"response_counts":{"helper_available":0,"helper_returned":0,"helper_truncated":false,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000105388"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-activity","query_id":"CH-ACT-CHEMBL3714583","raw_artifact":{"bytes":33917,"format":"json","sha256":"87f622fb4299d4e40e9fceb6a037c83ab6bc3380f19b5bef28ac613dde3a8edd","storage":"external-artifact-root"},"response_counts":{"helper_available":20,"helper_returned":20,"helper_truncated":false,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000196776"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-activity","query_id":"CH-ACT-CHEMBL3717","raw_artifact":{"bytes":35803,"format":"json","sha256":"4d6bb8da9a71290dff15f5bcabf9402fb0d04e60098efe3d0490ae2a48ee2f0f","storage":"external-artifact-root"},"response_counts":{"helper_available":20,"helper_returned":20,"helper_truncated":false,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000105976"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-activity","query_id":"CH-ACT-CHEMBL3856163","raw_artifact":{"bytes":109,"format":"json","sha256":"f95bb82987285813aadf8d59d1b3533323a27896c88d7a5375d195e8058fc1d7","storage":"external-artifact-root"},"response_counts":{"helper_available":0,"helper_returned":0,"helper_truncated":false,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000184292"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-activity","query_id":"CH-ACT-CHEMBL4683","raw_artifact":{"bytes":37118,"format":"json","sha256":"32913059aa2071c980a890bf1d4eb0e8226756a036faf95e9bfdd98769687f01","storage":"external-artifact-root"},"response_counts":{"helper_available":20,"helper_returned":20,"helper_truncated":false,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000078098"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-activity","query_id":"CH-ACT-CHEMBL5957","raw_artifact":{"bytes":42813,"format":"json","sha256":"5b2eb4d5ad0d352dc6721d7c3722386f09027393f539af919b9f1005a51d591e","storage":"external-artifact-root"},"response_counts":{"helper_available":20,"helper_returned":20,"helper_truncated":false,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000135318"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-molecule","query_id":"CH-MOL-CHEMBL176582","raw_artifact":{"bytes":3495,"format":"json","sha256":"cd2b2b13f5bf1bf4f6dbec74f50ff0e87a8dc668572df10d65567469bbc65c07","storage":"external-artifact-root"},"response_counts":{"helper_available":null,"helper_returned":null,"helper_truncated":null,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000146648"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-molecule","query_id":"CH-MOL-CHEMBL3582305","raw_artifact":{"bytes":4331,"format":"json","sha256":"c77c1c1f76be571013524d89e86462df416c5b76abb65fd68e5cd15d66ac7e9e","storage":"external-artifact-root"},"response_counts":{"helper_available":null,"helper_returned":null,"helper_truncated":null,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000105976"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-molecule","query_id":"CH-MOL-CHEMBL3668200","raw_artifact":{"bytes":4896,"format":"json","sha256":"08a3b89b6cc8a580e62bd44c866bede80ca3b736395c03c2c4f50d88fa32c58e","storage":"external-artifact-root"},"response_counts":{"helper_available":null,"helper_returned":null,"helper_truncated":null,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000105976"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-molecule","query_id":"CH-MOL-CHEMBL3797911","raw_artifact":{"bytes":4135,"format":"json","sha256":"d451a2ec200a5afe4dfe153250fec184e43b8232224eb15fd3ac2658d62f2b10","storage":"external-artifact-root"},"response_counts":{"helper_available":null,"helper_returned":null,"helper_truncated":null,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000105976"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-molecule","query_id":"CH-MOL-CHEMBL3891508","raw_artifact":{"bytes":11040,"format":"json","sha256":"52bbfa6a6c465e145c879358ed8c72e71765c68fe5b6172e08d9fc74cd1aebc3","storage":"external-artifact-root"},"response_counts":{"helper_available":null,"helper_returned":null,"helper_truncated":null,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000196776"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-molecule","query_id":"CH-MOL-CHEMBL3946082","raw_artifact":{"bytes":9377,"format":"json","sha256":"0dfb3f587560204e69711296f377516c739457797073626d2b9ad09a0a298784","storage":"external-artifact-root"},"response_counts":{"helper_available":null,"helper_returned":null,"helper_truncated":null,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000196776"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-molecule","query_id":"CH-MOL-CHEMBL3971661","raw_artifact":{"bytes":10757,"format":"json","sha256":"057554bed04b651bce5cf6a0d43df07c8023e7edd8b063e41108cf036f975fbd","storage":"external-artifact-root"},"response_counts":{"helper_available":null,"helper_returned":null,"helper_truncated":null,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000196776"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-molecule","query_id":"CH-MOL-CHEMBL3974452","raw_artifact":{"bytes":10747,"format":"json","sha256":"6eeb52554eedf984ff4e61c75aad1f1092d59784cbc6e2f27fe4172a73df9d33","storage":"external-artifact-root"},"response_counts":{"helper_available":null,"helper_returned":null,"helper_truncated":null,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000196776"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-molecule","query_id":"CH-MOL-CHEMBL4471306","raw_artifact":{"bytes":6034,"format":"json","sha256":"354413ec12c6ac85ef18cc88cfeee6bee288a5dce12e3cfb0fd0281f59910966","storage":"external-artifact-root"},"response_counts":{"helper_available":null,"helper_returned":null,"helper_truncated":null,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000135318"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-molecule","query_id":"CH-MOL-CHEMBL4522427","raw_artifact":{"bytes":32624,"format":"json","sha256":"30264342abd68dc54dfafa824c8ef45ec71791540f69ff95be3b60943238cab8","storage":"external-artifact-root"},"response_counts":{"helper_available":null,"helper_returned":null,"helper_truncated":null,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000196776"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-molecule","query_id":"CH-MOL-CHEMBL4650319","raw_artifact":{"bytes":6347,"format":"json","sha256":"9ac37363cbfb58322be4ee2650a6e79285c4c72958f3f77d93dfaf23ea89ba56","storage":"external-artifact-root"},"response_counts":{"helper_available":null,"helper_returned":null,"helper_truncated":null,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000146648"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-molecule","query_id":"CH-MOL-CHEMBL4761506","raw_artifact":{"bytes":4952,"format":"json","sha256":"b8f9da8ea663e90138cbfd4e671087445d65de572777c7ee5129405d5709f69b","storage":"external-artifact-root"},"response_counts":{"helper_available":null,"helper_returned":null,"helper_truncated":null,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000135318"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-molecule","query_id":"CH-MOL-CHEMBL4853661","raw_artifact":{"bytes":4992,"format":"json","sha256":"89d1a0dc2b33f82f225a8f1452d3df867e11211da27de9eff093a9a2cfa363dc","storage":"external-artifact-root"},"response_counts":{"helper_available":null,"helper_returned":null,"helper_truncated":null,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000078098"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-molecule","query_id":"CH-MOL-CHEMBL4864809","raw_artifact":{"bytes":4707,"format":"json","sha256":"809acf88c7c635b3da13f74629dc0a00c1ee45cabae28663bb2eb603f10c5f71","storage":"external-artifact-root"},"response_counts":{"helper_available":null,"helper_returned":null,"helper_truncated":null,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000078098"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-molecule","query_id":"CH-MOL-CHEMBL4877950","raw_artifact":{"bytes":4893,"format":"json","sha256":"556f470b57e5b9831c44cefcf36573b0ce755fe2fb4d9c676441c4ac9dcedd81","storage":"external-artifact-root"},"response_counts":{"helper_available":null,"helper_returned":null,"helper_truncated":null,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000078098"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-molecule","query_id":"CH-MOL-CHEMBL4878759","raw_artifact":{"bytes":4607,"format":"json","sha256":"4c9314852be73e4e6276a384fcb1cdf7127354f35f4588cd43e49e0279de7a6f","storage":"external-artifact-root"},"response_counts":{"helper_available":null,"helper_returned":null,"helper_truncated":null,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000078098"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-molecule","query_id":"CH-MOL-CHEMBL5174958","raw_artifact":{"bytes":4887,"format":"json","sha256":"7b6f0070347d08b40845e68fcf725c204303bae5453d96f9802c8e5635cffbbf","storage":"external-artifact-root"},"response_counts":{"helper_available":null,"helper_returned":null,"helper_truncated":null,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000105976"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-molecule","query_id":"CH-MOL-CHEMBL5184459","raw_artifact":{"bytes":4599,"format":"json","sha256":"6b1218847ece137aed4919c5bd55d027415d770153694ff1c7965964d2858bff","storage":"external-artifact-root"},"response_counts":{"helper_available":null,"helper_returned":null,"helper_truncated":null,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000105976"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-molecule","query_id":"CH-MOL-CHEMBL5221067","raw_artifact":{"bytes":3784,"format":"json","sha256":"8ba7b9d2309e46423aad77cf87748489530d1fe83df79c350cfbfe9806e5fd19","storage":"external-artifact-root"},"response_counts":{"helper_available":null,"helper_returned":null,"helper_truncated":null,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000141736"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-molecule","query_id":"CH-MOL-CHEMBL5270693","raw_artifact":{"bytes":5339,"format":"json","sha256":"f829fff69e02f53d6b5122f0c30d2f1dc7e6904a8c3b604f238eed9e0bafd9b4","storage":"external-artifact-root"},"response_counts":{"helper_available":null,"helper_returned":null,"helper_truncated":null,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000146648"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-molecule","query_id":"CH-MOL-CHEMBL5431118","raw_artifact":{"bytes":4857,"format":"json","sha256":"1a51c719781f3728277611268952ae36f1adb754940ecbf09424e3745440b8c7","storage":"external-artifact-root"},"response_counts":{"helper_available":null,"helper_returned":null,"helper_truncated":null,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000135318"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-molecule","query_id":"CH-MOL-CHEMBL5653589","raw_artifact":{"bytes":4871,"format":"json","sha256":"a5e98d5db4784ad2aefad9174a5f1dfc437f28dde35d6f54bfd85acf01aaa04d","storage":"external-artifact-root"},"response_counts":{"helper_available":null,"helper_returned":null,"helper_truncated":null,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000119888"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-molecule","query_id":"CH-MOL-CHEMBL5746224","raw_artifact":{"bytes":4347,"format":"json","sha256":"cc34820ae245a2438d120572e9ab5e4719ae8af15946fe2a237e45edc93bc1b9","storage":"external-artifact-root"},"response_counts":{"helper_available":null,"helper_returned":null,"helper_truncated":null,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000146648"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-molecule","query_id":"CH-MOL-CHEMBL5790648","raw_artifact":{"bytes":4341,"format":"json","sha256":"e2b0f127de682f4508569110106315cad9e1a9aad6195e6753124737a8e42d29","storage":"external-artifact-root"},"response_counts":{"helper_available":null,"helper_returned":null,"helper_truncated":null,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000146648"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-molecule","query_id":"CH-MOL-CHEMBL5939267","raw_artifact":{"bytes":7432,"format":"json","sha256":"88a4fb03e804c6ad6bfae0e6c83030b18347145e72fb7905703a4071257d6020","storage":"external-artifact-root"},"response_counts":{"helper_available":null,"helper_returned":null,"helper_truncated":null,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000141736"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-molecule","query_id":"CH-MOL-CHEMBL6019933","raw_artifact":{"bytes":7147,"format":"json","sha256":"1f15f479fde75db81246fe9fb1e477e073695bf1e42c9439ed4829c5e68e0e63","storage":"external-artifact-root"},"response_counts":{"helper_available":null,"helper_returned":null,"helper_truncated":null,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000141736"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-molecule","query_id":"CH-MOL-CHEMBL6132997","raw_artifact":{"bytes":7669,"format":"json","sha256":"6ddeb85ef5682bf4e024275622de3c1ae860dc959340fc65e4bfe90d98048523","storage":"external-artifact-root"},"response_counts":{"helper_available":null,"helper_returned":null,"helper_truncated":null,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000141736"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-molecule","query_id":"CH-MOL-CHEMBL6147832","raw_artifact":{"bytes":8066,"format":"json","sha256":"d79de0098cf83775f1062f5b8ea3c310613246f27b1e8ed383e2f310b19737c5","storage":"external-artifact-root"},"response_counts":{"helper_available":null,"helper_returned":null,"helper_truncated":null,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000078098"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-molecule","query_id":"CH-MOL-CHEMBL6152291","raw_artifact":{"bytes":4612,"format":"json","sha256":"93af402eac1e214a0e464622762b8ef1f8a6507b5b686463df8c5a69eda64a70","storage":"external-artifact-root"},"response_counts":{"helper_available":null,"helper_returned":null,"helper_truncated":null,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000135318"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-molecule","query_id":"CH-MOL-CHEMBL6162112","raw_artifact":{"bytes":4700,"format":"json","sha256":"3415c2715e39fe99020ab503cba53a0493704772ba7589054e8f8eed64e47b16","storage":"external-artifact-root"},"response_counts":{"helper_available":null,"helper_returned":null,"helper_truncated":null,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000135318"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"chembl-molecule","query_id":"CH-MOL-CHEMBL941","raw_artifact":{"bytes":7151,"format":"json","sha256":"8054e22675925baca2e3d249289ebd88d223c0af56dd607e2a888042b640fe4d","storage":"external-artifact-root"},"response_counts":{"helper_available":null,"helper_returned":null,"helper_truncated":null,"raw_affinity_records":null},"source":"chembl","status":"complete","target_ids":["T-ENSG00000141736"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"bindingdb-pdb","query_id":"BDB-PDB-1N8Z","raw_artifact":{"bytes":301995,"format":"json","sha256":"ef605ed13f3046a83af4d373cbbcb8ac1f57578e4221cff44cbfd1a7e0e31918","storage":"external-artifact-root"},"response_counts":{"helper_available":988,"helper_returned":10,"helper_truncated":true,"raw_affinity_records":988},"source":"bindingdb","status":"complete","target_ids":["T-ENSG00000141736"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":"Request failed for bindingdb-skill: HTTPError","kind":"bindingdb-pdb","query_id":"BDB-PDB-1YY9","raw_artifact":null,"response_counts":{"helper_available":null,"helper_returned":null,"helper_truncated":null,"raw_affinity_records":null},"source":"bindingdb","status":"failed","target_ids":["T-ENSG00000146648"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":"Request failed for bindingdb-skill: HTTPError","kind":"bindingdb-pdb","query_id":"BDB-PDB-2JJS","raw_artifact":null,"response_counts":{"helper_available":null,"helper_returned":null,"helper_truncated":null,"raw_affinity_records":null},"source":"bindingdb","status":"failed","target_ids":["T-ENSG00000196776"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"bindingdb-pdb","query_id":"BDB-PDB-4K3J","raw_artifact":{"bytes":801680,"format":"json","sha256":"1ab2d245f0147cbbf401932cb332b3d1356530668cf7661a3a8db935ef85c639","storage":"external-artifact-root"},"response_counts":{"helper_available":2691,"helper_returned":10,"helper_truncated":true,"raw_affinity_records":2691},"source":"bindingdb","status":"complete","target_ids":["T-ENSG00000105976"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":"Request failed for bindingdb-skill: HTTPError","kind":"bindingdb-pdb","query_id":"BDB-PDB-6I07","raw_artifact":null,"response_counts":{"helper_available":null,"helper_returned":null,"helper_truncated":null,"raw_affinity_records":null},"source":"bindingdb","status":"failed","target_ids":["T-ENSG00000119888"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"bindingdb-pdb","query_id":"BDB-PDB-6Y0F","raw_artifact":{"bytes":297870,"format":"json","sha256":"17719b6f486432298af0badd1703cf9f19b4555ab4dce3f62f747c1cdfc7fec9","storage":"external-artifact-root"},"response_counts":{"helper_available":985,"helper_returned":10,"helper_truncated":true,"raw_affinity_records":985},"source":"bindingdb","status":"complete","target_ids":["T-ENSG00000078098"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":"Request failed for bindingdb-skill: HTTPError","kind":"bindingdb-pdb","query_id":"BDB-PDB-7BBJ","raw_artifact":null,"response_counts":{"helper_available":null,"helper_returned":null,"helper_truncated":null,"raw_affinity_records":null},"source":"bindingdb","status":"failed","target_ids":["T-ENSG00000135318"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":"Request failed for bindingdb-skill: HTTPError","kind":"bindingdb-pdb","query_id":"BDB-PDB-8BW0","raw_artifact":null,"response_counts":{"helper_available":null,"helper_returned":null,"helper_truncated":null,"raw_affinity_records":null},"source":"bindingdb","status":"failed","target_ids":["T-ENSG00000105388"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":"Request failed for bindingdb-skill: HTTPError","kind":"bindingdb-pdb","query_id":"BDB-PDB-8GHP","raw_artifact":null,"response_counts":{"helper_available":null,"helper_returned":null,"helper_truncated":null,"raw_affinity_records":null},"source":"bindingdb","status":"failed","target_ids":["T-ENSG00000070019"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"bindingdb-pdb","query_id":"BDB-PDB-9DVR","raw_artifact":{"bytes":297870,"format":"json","sha256":"17719b6f486432298af0badd1703cf9f19b4555ab4dce3f62f747c1cdfc7fec9","storage":"external-artifact-root"},"response_counts":{"helper_available":985,"helper_returned":10,"helper_truncated":true,"raw_affinity_records":985},"source":"bindingdb","status":"complete","target_ids":["T-ENSG00000078098"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":"Request failed for bindingdb-skill: HTTPError","kind":"bindingdb-pdb","query_id":"BDB-PDB-9PI9","raw_artifact":null,"response_counts":{"helper_available":null,"helper_returned":null,"helper_truncated":null,"raw_affinity_records":null},"source":"bindingdb","status":"failed","target_ids":["T-ENSG00000184292"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":"Request failed for bindingdb-skill: HTTPError","kind":"bindingdb-pdb","query_id":"BDB-PDB-9R0G","raw_artifact":null,"response_counts":{"helper_available":null,"helper_returned":null,"helper_truncated":null,"raw_affinity_records":null},"source":"bindingdb","status":"failed","target_ids":["T-ENSG00000135318"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"bindingdb-uniprot","query_id":"BDB-UNI-P00533","raw_artifact":{"bytes":2808330,"format":"json","sha256":"c5789881a83ac01c9e5c1582d65c0aeeedaa841c6f755a419bbbee1653278128","storage":"external-artifact-root"},"response_counts":{"helper_available":9597,"helper_returned":10,"helper_truncated":true,"raw_affinity_records":9597},"source":"bindingdb","status":"complete","target_ids":["T-ENSG00000146648"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"bindingdb-uniprot","query_id":"BDB-UNI-P04626","raw_artifact":{"bytes":310951,"format":"json","sha256":"01ffb2c84cb5e725dd54e662c06f527a3a156f8310bb1bee6d5c4c35bb3ca66e","storage":"external-artifact-root"},"response_counts":{"helper_available":1019,"helper_returned":10,"helper_truncated":true,"raw_affinity_records":1019},"source":"bindingdb","status":"complete","target_ids":["T-ENSG00000141736"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"bindingdb-uniprot","query_id":"BDB-UNI-P06731","raw_artifact":{"bytes":65,"format":"json","sha256":"09bc0dde35898b010ae89187a1db4d6823b1268b81306ca5cb346dc97201d7bb","storage":"external-artifact-root"},"response_counts":{"helper_available":0,"helper_returned":0,"helper_truncated":false,"raw_affinity_records":0},"source":"bindingdb","status":"complete","target_ids":["T-ENSG00000105388"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"bindingdb-uniprot","query_id":"BDB-UNI-P08581","raw_artifact":{"bytes":820747,"format":"json","sha256":"ea93981ea5f4b2fda096d36167449bf4aca3b216f0e28578edceff45a66d85ac","storage":"external-artifact-root"},"response_counts":{"helper_available":2757,"helper_returned":10,"helper_truncated":true,"raw_affinity_records":2757},"source":"bindingdb","status":"complete","target_ids":["T-ENSG00000105976"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"bindingdb-uniprot","query_id":"BDB-UNI-P09758","raw_artifact":{"bytes":65,"format":"json","sha256":"09bc0dde35898b010ae89187a1db4d6823b1268b81306ca5cb346dc97201d7bb","storage":"external-artifact-root"},"response_counts":{"helper_available":0,"helper_returned":0,"helper_truncated":false,"raw_affinity_records":0},"source":"bindingdb","status":"complete","target_ids":["T-ENSG00000184292"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"bindingdb-uniprot","query_id":"BDB-UNI-P16422","raw_artifact":{"bytes":362,"format":"json","sha256":"5dcb0b8c34d2fc65f24ac1c95064f7f0f27dbdf08507933f7e756e4a30d0cdd7","storage":"external-artifact-root"},"response_counts":{"helper_available":1,"helper_returned":1,"helper_truncated":false,"raw_affinity_records":1},"source":"bindingdb","status":"complete","target_ids":["T-ENSG00000119888"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"bindingdb-uniprot","query_id":"BDB-UNI-P21589","raw_artifact":{"bytes":252579,"format":"json","sha256":"c96247b61fc7e166471a28e42f4ef643810cdd8c37c4d2da249375d5a9a2fb56","storage":"external-artifact-root"},"response_counts":{"helper_available":874,"helper_returned":10,"helper_truncated":true,"raw_affinity_records":874},"source":"bindingdb","status":"complete","target_ids":["T-ENSG00000135318"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"bindingdb-uniprot","query_id":"BDB-UNI-P25092","raw_artifact":{"bytes":65,"format":"json","sha256":"09bc0dde35898b010ae89187a1db4d6823b1268b81306ca5cb346dc97201d7bb","storage":"external-artifact-root"},"response_counts":{"helper_available":0,"helper_returned":0,"helper_truncated":false,"raw_affinity_records":0},"source":"bindingdb","status":"complete","target_ids":["T-ENSG00000070019"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"bindingdb-uniprot","query_id":"BDB-UNI-Q08722","raw_artifact":{"bytes":65,"format":"json","sha256":"09bc0dde35898b010ae89187a1db4d6823b1268b81306ca5cb346dc97201d7bb","storage":"external-artifact-root"},"response_counts":{"helper_available":0,"helper_returned":0,"helper_truncated":false,"raw_affinity_records":0},"source":"bindingdb","status":"complete","target_ids":["T-ENSG00000196776"]},{"cache_reused":true,"claim_ceiling":"bounded database lookup; absence or truncation is not evidence of no binding","error":null,"kind":"bindingdb-uniprot","query_id":"BDB-UNI-Q12884","raw_artifact":{"bytes":297874,"format":"json","sha256":"5e2f82dc320232bb2d3b3bcccfee7e97353d367f584a8e4bb3ea66c75e5f91fd","storage":"external-artifact-root"},"response_counts":{"helper_available":985,"helper_returned":10,"helper_truncated":true,"raw_affinity_records":985},"source":"bindingdb","status":"complete","target_ids":["T-ENSG00000078098"]}],"records":[{"claim_ceiling":"measured BindingDB target affinity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":"This target contains an intracellular catalytic domain; kinase/catalytic inhibitors must not be treated as extracellular surface-site evidence.","matched_actionable_site_ids":[],"reason":"BindingDB used the deposited PDB as a target/sequence lookup. The returned affinity does not prove that the ligand occupies the deposited extracellular site.","state":"pdb-indexed-target-match-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"MET","interaction_id":"KCI-BINDINGDB-07b5180568b7a80a","measurement":{"activity_id":null,"doi":"10.7270/Q23X8C0F","pmid":null,"query_target_label":"Hepatocyte growth factor receptor","relation":null,"type":"IC50","units":"nM","units_provenance":"BindingDB REST affinity/cutoff convention","value":"0.001"},"molecule":{"canonical_smiles":"CNC(=S)c1ccc(cc1F)-c1cnc2ncc(C(O)c3ccc4ncccc4c3)n2n1","molecule_type":"small molecule","preferred_name":null,"source_molecule_id":"694666","standard_inchi":null,"standard_inchi_key":null},"query_ids":["BDB-PDB-4K3J","BDB-UNI-P08581"],"source":"BindingDB","source_target_id":"P08581","target_id":"T-ENSG00000105976","target_resolution":"exact-uniprot-query-or-100-percent-pdb-sequence-match","uniprot_accession":"P08581"},{"claim_ceiling":"measured BindingDB target affinity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":"This target contains an intracellular catalytic domain; kinase/catalytic inhibitors must not be treated as extracellular surface-site evidence.","matched_actionable_site_ids":[],"reason":"BindingDB used the deposited PDB as a target/sequence lookup. The returned affinity does not prove that the ligand occupies the deposited extracellular site.","state":"pdb-indexed-target-match-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"MET","interaction_id":"KCI-BINDINGDB-086ad40138f8ffc9","measurement":{"activity_id":null,"doi":"10.7270/Q23X8C0F","pmid":null,"query_target_label":"Hepatocyte growth factor receptor","relation":null,"type":"IC50","units":"nM","units_provenance":"BindingDB REST affinity/cutoff convention","value":"0.001"},"molecule":{"canonical_smiles":"CNC(=S)c1ccc(cc1F)-c1cnc2ncc(Cc3ccc4occc4c3)n2n1","molecule_type":"small molecule","preferred_name":null,"source_molecule_id":"694663","standard_inchi":null,"standard_inchi_key":null},"query_ids":["BDB-PDB-4K3J","BDB-UNI-P08581"],"source":"BindingDB","source_target_id":"P08581","target_id":"T-ENSG00000105976","target_resolution":"exact-uniprot-query-or-100-percent-pdb-sequence-match","uniprot_accession":"P08581"},{"claim_ceiling":"measured BindingDB target affinity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":null,"matched_actionable_site_ids":[],"reason":"BindingDB used the deposited PDB as a target/sequence lookup. The returned affinity does not prove that the ligand occupies the deposited extracellular site.","state":"pdb-indexed-target-match-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"FAP","interaction_id":"KCI-BINDINGDB-0ac9eba24bfde384","measurement":{"activity_id":null,"doi":"10.7270/Q21R6VP3","pmid":null,"query_target_label":"Prolyl endopeptidase FAP","relation":null,"type":"Kd","units":"nM","units_provenance":"BindingDB REST affinity/cutoff convention","value":"0.006"},"molecule":{"canonical_smiles":"O=C(CNC(=O)c1ccnc2ccc(cc12)N1C[C@@H]2C[C@H]1CO2)N1CSC[C@H]1C#N |r|","molecule_type":"small molecule","preferred_name":null,"source_molecule_id":"622115","standard_inchi":null,"standard_inchi_key":null},"query_ids":["BDB-PDB-6Y0F","BDB-PDB-9DVR","BDB-UNI-Q12884"],"source":"BindingDB","source_target_id":"Q12884","target_id":"T-ENSG00000078098","target_resolution":"exact-uniprot-query-or-100-percent-pdb-sequence-match","uniprot_accession":"Q12884"},{"claim_ceiling":"measured BindingDB target affinity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":"This target contains an intracellular catalytic domain; kinase/catalytic inhibitors must not be treated as extracellular surface-site evidence.","matched_actionable_site_ids":[],"reason":"BindingDB used the deposited PDB as a target/sequence lookup. The returned affinity does not prove that the ligand occupies the deposited extracellular site.","state":"pdb-indexed-target-match-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"ERBB2","interaction_id":"KCI-BINDINGDB-105a0ec5c5afc361","measurement":{"activity_id":null,"doi":"10.7270/Q2ZC84ZB","pmid":null,"query_target_label":"Receptor tyrosine-protein kinase erbB-2","relation":null,"type":"IC50","units":"nM","units_provenance":"BindingDB REST affinity/cutoff convention","value":"0.060"},"molecule":{"canonical_smiles":"COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(C(=O)Nc3cc(C(=O)Nc4cc(C(=O)n5ccc6cc(N)ccc65)n(C)c4)n(C)c3)n1)N=C[C@@H]1Cc3ccccc3N1C2=O","molecule_type":"small molecule","preferred_name":null,"source_molecule_id":"304254","standard_inchi":null,"standard_inchi_key":null},"query_ids":["BDB-PDB-1N8Z","BDB-UNI-P04626"],"source":"BindingDB","source_target_id":"P04626","target_id":"T-ENSG00000141736","target_resolution":"exact-uniprot-query-or-100-percent-pdb-sequence-match","uniprot_accession":"P04626"},{"claim_ceiling":"measured BindingDB target affinity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":"This target contains an intracellular catalytic domain; kinase/catalytic inhibitors must not be treated as extracellular surface-site evidence.","matched_actionable_site_ids":[],"reason":"BindingDB used the deposited PDB as a target/sequence lookup. The returned affinity does not prove that the ligand occupies the deposited extracellular site.","state":"pdb-indexed-target-match-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"ERBB2","interaction_id":"KCI-BINDINGDB-1fa8c2e7dbcb2120","measurement":{"activity_id":null,"doi":"10.7270/Q2K64P50","pmid":"35696863","query_target_label":"Receptor tyrosine-protein kinase erbB-2","relation":null,"type":"IC50","units":"nM","units_provenance":"BindingDB REST affinity/cutoff convention","value":"0.060000"},"molecule":{"canonical_smiles":"CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1","molecule_type":"small molecule","preferred_name":null,"source_molecule_id":"13530","standard_inchi":null,"standard_inchi_key":null},"query_ids":["BDB-PDB-1N8Z","BDB-UNI-P04626"],"source":"BindingDB","source_target_id":"P04626","target_id":"T-ENSG00000141736","target_resolution":"exact-uniprot-query-or-100-percent-pdb-sequence-match","uniprot_accession":"P04626"},{"claim_ceiling":"measured BindingDB target affinity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":null,"matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"NT5E","interaction_id":"KCI-BINDINGDB-28c1c93d467d5e41","measurement":{"activity_id":null,"doi":"10.1021/acs.jmedchem.0c00525","pmid":"32614585","query_target_label":"5'-nucleotidase","relation":null,"type":"IC50","units":"nM","units_provenance":"BindingDB REST affinity/cutoff convention","value":"0.008000"},"molecule":{"canonical_smiles":"C[C@@H](c1ccccc1F)Nc2cc(nc3c2cnn3[C@H]4[C@@H]([C@@H]([C@H](O4)COP(=O)(CP(=O)(O)O)O)O)O)Cl","molecule_type":"small molecule","preferred_name":null,"source_molecule_id":"50527134","standard_inchi":null,"standard_inchi_key":null},"query_ids":["BDB-UNI-P21589"],"source":"BindingDB","source_target_id":"P21589","target_id":"T-ENSG00000135318","target_resolution":"exact-uniprot-query-or-100-percent-pdb-sequence-match","uniprot_accession":"P21589"},{"claim_ceiling":"measured BindingDB target affinity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":null,"matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"NT5E","interaction_id":"KCI-BINDINGDB-29aeb14112f4c59d","measurement":{"activity_id":null,"doi":"10.1021/acs.jmedchem.0c00525","pmid":"32614585","query_target_label":"5'-nucleotidase","relation":null,"type":"IC50","units":"nM","units_provenance":"BindingDB REST affinity/cutoff convention","value":"0.010000"},"molecule":{"canonical_smiles":"C[C@@H](c1ccc(cc1)F)Nc2cc(nc3c2cnn3[C@H]4[C@@H]([C@@H]([C@H](O4)COP(=O)(CP(=O)(O)O)O)O)O)Cl","molecule_type":"small molecule","preferred_name":null,"source_molecule_id":"50546280","standard_inchi":null,"standard_inchi_key":null},"query_ids":["BDB-UNI-P21589"],"source":"BindingDB","source_target_id":"P21589","target_id":"T-ENSG00000135318","target_resolution":"exact-uniprot-query-or-100-percent-pdb-sequence-match","uniprot_accession":"P21589"},{"claim_ceiling":"measured BindingDB target affinity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":"This target contains an intracellular catalytic domain; kinase/catalytic inhibitors must not be treated as extracellular surface-site evidence.","matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"EGFR","interaction_id":"KCI-BINDINGDB-45e84700f5818806","measurement":{"activity_id":null,"doi":"10.1021/jm950692f","pmid":"8632415","query_target_label":"Epidermal growth factor receptor","relation":null,"type":"IC50","units":"nM","units_provenance":"BindingDB REST affinity/cutoff convention","value":"0.003"},"molecule":{"canonical_smiles":"Brc1cccc(Nc2ncnc3cc4ccccc4cc23)c1","molecule_type":"small molecule","preferred_name":null,"source_molecule_id":"3585","standard_inchi":null,"standard_inchi_key":null},"query_ids":["BDB-UNI-P00533"],"source":"BindingDB","source_target_id":"P00533","target_id":"T-ENSG00000146648","target_resolution":"exact-uniprot-query-or-100-percent-pdb-sequence-match","uniprot_accession":"P00533"},{"claim_ceiling":"measured BindingDB target affinity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":null,"matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"NT5E","interaction_id":"KCI-BINDINGDB-4ca4e279a02ca5b9","measurement":{"activity_id":null,"doi":"10.7270/Q25D8XJP","pmid":"37302340","query_target_label":"5'-nucleotidase","relation":null,"type":"Ki","units":"nM","units_provenance":"BindingDB REST affinity/cutoff convention","value":"0.005000"},"molecule":{"canonical_smiles":"C[C@H](Nc1cc(Cl)nc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O)c1ccccc1F","molecule_type":"small molecule","preferred_name":null,"source_molecule_id":"50650167","standard_inchi":null,"standard_inchi_key":null},"query_ids":["BDB-UNI-P21589"],"source":"BindingDB","source_target_id":"P21589","target_id":"T-ENSG00000135318","target_resolution":"exact-uniprot-query-or-100-percent-pdb-sequence-match","uniprot_accession":"P21589"},{"claim_ceiling":"measured BindingDB target affinity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":null,"matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"EPCAM","interaction_id":"KCI-BINDINGDB-5116757b4315b4d0","measurement":{"activity_id":null,"doi":"10.7270/Q22N5711","pmid":"29928781","query_target_label":"Epithelial cell adhesion molecule","relation":null,"type":"Kd","units":"nM","units_provenance":"BindingDB REST affinity/cutoff convention","value":"0.472000"},"molecule":{"canonical_smiles":"Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12","molecule_type":"small molecule","preferred_name":null,"source_molecule_id":"50652793","standard_inchi":null,"standard_inchi_key":null},"query_ids":["BDB-UNI-P16422"],"source":"BindingDB","source_target_id":"P16422","target_id":"T-ENSG00000119888","target_resolution":"exact-uniprot-query-or-100-percent-pdb-sequence-match","uniprot_accession":"P16422"},{"claim_ceiling":"measured BindingDB target affinity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":"This target contains an intracellular catalytic domain; kinase/catalytic inhibitors must not be treated as extracellular surface-site evidence.","matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"EGFR","interaction_id":"KCI-BINDINGDB-6208f22d1f1d6c16","measurement":{"activity_id":null,"doi":"10.1021/jm9503613","pmid":"8568816","query_target_label":"Epidermal growth factor receptor","relation":null,"type":"IC50","units":"nM","units_provenance":"BindingDB REST affinity/cutoff convention","value":"0.006"},"molecule":{"canonical_smiles":"CCOc1cc2ncnc(Nc3cccc(Br)c3)c2cc1OCC","molecule_type":"small molecule","preferred_name":null,"source_molecule_id":"3556","standard_inchi":null,"standard_inchi_key":null},"query_ids":["BDB-UNI-P00533"],"source":"BindingDB","source_target_id":"P00533","target_id":"T-ENSG00000146648","target_resolution":"exact-uniprot-query-or-100-percent-pdb-sequence-match","uniprot_accession":"P00533"},{"claim_ceiling":"measured BindingDB target affinity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":"This target contains an intracellular catalytic domain; kinase/catalytic inhibitors must not be treated as extracellular surface-site evidence.","matched_actionable_site_ids":[],"reason":"BindingDB used the deposited PDB as a target/sequence lookup. The returned affinity does not prove that the ligand occupies the deposited extracellular site.","state":"pdb-indexed-target-match-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"ERBB2","interaction_id":"KCI-BINDINGDB-68892344b2bdbb35","measurement":{"activity_id":null,"doi":"10.7270/Q2BC44CM","pmid":"39059182","query_target_label":"Receptor tyrosine-protein kinase erbB-2","relation":null,"type":"IC50","units":"nM","units_provenance":"BindingDB REST affinity/cutoff convention","value":"0.040000"},"molecule":{"canonical_smiles":"COc1cc2c(Nc3ccc(Oc4ccn5ncnc5c4)c(C)c3)ncnc2cc1OCCCN1CCN(CCCCCCCNc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","molecule_type":"small molecule","preferred_name":null,"source_molecule_id":"50654486","standard_inchi":null,"standard_inchi_key":null},"query_ids":["BDB-PDB-1N8Z","BDB-UNI-P04626"],"source":"BindingDB","source_target_id":"P04626","target_id":"T-ENSG00000141736","target_resolution":"exact-uniprot-query-or-100-percent-pdb-sequence-match","uniprot_accession":"P04626"},{"claim_ceiling":"measured BindingDB target affinity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":null,"matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"NT5E","interaction_id":"KCI-BINDINGDB-737fe486bdd27f84","measurement":{"activity_id":null,"doi":"10.1021/acs.jmedchem.0c00525","pmid":"32614585","query_target_label":"5'-nucleotidase","relation":null,"type":"IC50","units":"nM","units_provenance":"BindingDB REST affinity/cutoff convention","value":"0.002700"},"molecule":{"canonical_smiles":"C[C@H](Nc1nc(Cl)nc2n(ncc12)[C@@H]1O[C@H](COP(O)(=O)CP(O)(O)=O)[C@@H](O)[C@H]1O)c1ccccc1 |r|","molecule_type":"small molecule","preferred_name":null,"source_molecule_id":"50546288","standard_inchi":null,"standard_inchi_key":null},"query_ids":["BDB-UNI-P21589"],"source":"BindingDB","source_target_id":"P21589","target_id":"T-ENSG00000135318","target_resolution":"exact-uniprot-query-or-100-percent-pdb-sequence-match","uniprot_accession":"P21589"},{"claim_ceiling":"measured BindingDB target affinity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":"This target contains an intracellular catalytic domain; kinase/catalytic inhibitors must not be treated as extracellular surface-site evidence.","matched_actionable_site_ids":[],"reason":"BindingDB used the deposited PDB as a target/sequence lookup. The returned affinity does not prove that the ligand occupies the deposited extracellular site.","state":"pdb-indexed-target-match-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"ERBB2","interaction_id":"KCI-BINDINGDB-76ea6126757b4230","measurement":{"activity_id":null,"doi":"10.7270/Q2ZC84ZB","pmid":null,"query_target_label":"Receptor tyrosine-protein kinase erbB-2","relation":null,"type":"IC50","units":"nM","units_provenance":"BindingDB REST affinity/cutoff convention","value":"0.090"},"molecule":{"canonical_smiles":"C=C1C[C@H]2C=Nc3cc(OCCCC(=O)Nc4cn(C)c(C(=O)Nc5cc(C(=O)Nc6cc(C(=O)n7ncc8cc(N)ccc87)n(C)c6)n(C)c5)n4)c(OC)cc3C(=O)N2C1","molecule_type":"small molecule","preferred_name":null,"source_molecule_id":"304255","standard_inchi":null,"standard_inchi_key":null},"query_ids":["BDB-PDB-1N8Z","BDB-UNI-P04626"],"source":"BindingDB","source_target_id":"P04626","target_id":"T-ENSG00000141736","target_resolution":"exact-uniprot-query-or-100-percent-pdb-sequence-match","uniprot_accession":"P04626"},{"claim_ceiling":"measured BindingDB target affinity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":"This target contains an intracellular catalytic domain; kinase/catalytic inhibitors must not be treated as extracellular surface-site evidence.","matched_actionable_site_ids":[],"reason":"BindingDB used the deposited PDB as a target/sequence lookup. The returned affinity does not prove that the ligand occupies the deposited extracellular site.","state":"pdb-indexed-target-match-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"MET","interaction_id":"KCI-BINDINGDB-7e6ba957e80bed5b","measurement":{"activity_id":null,"doi":"10.7270/Q23X8C0F","pmid":null,"query_target_label":"Hepatocyte growth factor receptor","relation":null,"type":"IC50","units":"nM","units_provenance":"BindingDB REST affinity/cutoff convention","value":"0.002"},"molecule":{"canonical_smiles":"CN(C)C(=S)c1ccc(cc1F)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1","molecule_type":"small molecule","preferred_name":null,"source_molecule_id":"694647","standard_inchi":null,"standard_inchi_key":null},"query_ids":["BDB-PDB-4K3J","BDB-UNI-P08581"],"source":"BindingDB","source_target_id":"P08581","target_id":"T-ENSG00000105976","target_resolution":"exact-uniprot-query-or-100-percent-pdb-sequence-match","uniprot_accession":"P08581"},{"claim_ceiling":"measured BindingDB target affinity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":null,"matched_actionable_site_ids":[],"reason":"BindingDB used the deposited PDB as a target/sequence lookup. The returned affinity does not prove that the ligand occupies the deposited extracellular site.","state":"pdb-indexed-target-match-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"FAP","interaction_id":"KCI-BINDINGDB-8a02e58de3e24193","measurement":{"activity_id":null,"doi":"10.7270/Q21R6VP3","pmid":null,"query_target_label":"Prolyl endopeptidase FAP","relation":null,"type":"Kd","units":"nM","units_provenance":"BindingDB REST affinity/cutoff convention","value":"0.006"},"molecule":{"canonical_smiles":"CC(C)OC1CCN(CC1)c1ccc2nccc(C(=O)NCC(=O)N3CSC[C@H]3C#N)c2c1 |r|","molecule_type":"small molecule","preferred_name":null,"source_molecule_id":"622083","standard_inchi":null,"standard_inchi_key":null},"query_ids":["BDB-PDB-6Y0F","BDB-PDB-9DVR","BDB-UNI-Q12884"],"source":"BindingDB","source_target_id":"Q12884","target_id":"T-ENSG00000078098","target_resolution":"exact-uniprot-query-or-100-percent-pdb-sequence-match","uniprot_accession":"Q12884"},{"claim_ceiling":"measured BindingDB target affinity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":"This target contains an intracellular catalytic domain; kinase/catalytic inhibitors must not be treated as extracellular surface-site evidence.","matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"EGFR","interaction_id":"KCI-BINDINGDB-8e6d653dad238487","measurement":{"activity_id":null,"doi":"10.1016/j.bmc.2018.02.022","pmid":"29523467","query_target_label":"Epidermal growth factor receptor","relation":null,"type":"IC50","units":"nM","units_provenance":"BindingDB REST affinity/cutoff convention","value":"0.002000"},"molecule":{"canonical_smiles":"COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cn(C)c2ccccc12","molecule_type":"small molecule","preferred_name":null,"source_molecule_id":"50029668","standard_inchi":null,"standard_inchi_key":null},"query_ids":["BDB-UNI-P00533"],"source":"BindingDB","source_target_id":"P00533","target_id":"T-ENSG00000146648","target_resolution":"exact-uniprot-query-or-100-percent-pdb-sequence-match","uniprot_accession":"P00533"},{"claim_ceiling":"measured BindingDB target affinity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":"This target contains an intracellular catalytic domain; kinase/catalytic inhibitors must not be treated as extracellular surface-site evidence.","matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"EGFR","interaction_id":"KCI-BINDINGDB-9dd515e75e406f98","measurement":{"activity_id":null,"doi":"10.1073/pnas.0708800104","pmid":"18077363","query_target_label":"Epidermal growth factor receptor","relation":null,"type":"Ki","units":"nM","units_provenance":"BindingDB REST affinity/cutoff convention","value":"0.006"},"molecule":{"canonical_smiles":"COc1cc2ncnc(Nc3cccc(Br)c3)c2cc1OC","molecule_type":"small molecule","preferred_name":null,"source_molecule_id":"3032","standard_inchi":null,"standard_inchi_key":null},"query_ids":["BDB-UNI-P00533"],"source":"BindingDB","source_target_id":"P00533","target_id":"T-ENSG00000146648","target_resolution":"exact-uniprot-query-or-100-percent-pdb-sequence-match","uniprot_accession":"P00533"},{"claim_ceiling":"measured BindingDB target affinity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":"This target contains an intracellular catalytic domain; kinase/catalytic inhibitors must not be treated as extracellular surface-site evidence.","matched_actionable_site_ids":[],"reason":"BindingDB used the deposited PDB as a target/sequence lookup. The returned affinity does not prove that the ligand occupies the deposited extracellular site.","state":"pdb-indexed-target-match-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"ERBB2","interaction_id":"KCI-BINDINGDB-ad246683fd17786d","measurement":{"activity_id":null,"doi":"10.1021/jm501578n","pmid":"25383627","query_target_label":"Receptor tyrosine-protein kinase erbB-2","relation":null,"type":"Ki","units":"nM","units_provenance":"BindingDB REST affinity/cutoff convention","value":"0.100000"},"molecule":{"canonical_smiles":"COCCOc1cc2c(cc1OCCOC)ncnc2Nc3cccc(c3)C#C","molecule_type":"small molecule","preferred_name":null,"source_molecule_id":"5446","standard_inchi":null,"standard_inchi_key":null},"query_ids":["BDB-PDB-1N8Z","BDB-UNI-P04626"],"source":"BindingDB","source_target_id":"P04626","target_id":"T-ENSG00000141736","target_resolution":"exact-uniprot-query-or-100-percent-pdb-sequence-match","uniprot_accession":"P04626"},{"claim_ceiling":"measured BindingDB target affinity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":"This target contains an intracellular catalytic domain; kinase/catalytic inhibitors must not be treated as extracellular surface-site evidence.","matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"EGFR","interaction_id":"KCI-BINDINGDB-d0212c8a52918ef8","measurement":{"activity_id":null,"doi":"10.1021/jm9508651","pmid":"8627606","query_target_label":"Epidermal growth factor receptor","relation":null,"type":"IC50","units":"nM","units_provenance":"BindingDB REST affinity/cutoff convention","value":"0.006"},"molecule":{"canonical_smiles":"CN(C)c1cc2c(Nc3cccc(Br)c3)ncnc2cn1","molecule_type":"small molecule","preferred_name":null,"source_molecule_id":"3604","standard_inchi":null,"standard_inchi_key":null},"query_ids":["BDB-UNI-P00533"],"source":"BindingDB","source_target_id":"P00533","target_id":"T-ENSG00000146648","target_resolution":"exact-uniprot-query-or-100-percent-pdb-sequence-match","uniprot_accession":"P00533"},{"claim_ceiling":"measured BindingDB target affinity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":null,"matched_actionable_site_ids":[],"reason":"BindingDB used the deposited PDB as a target/sequence lookup. The returned affinity does not prove that the ligand occupies the deposited extracellular site.","state":"pdb-indexed-target-match-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"FAP","interaction_id":"KCI-BINDINGDB-de51191c2a73a9a3","measurement":{"activity_id":null,"doi":"10.7270/Q21R6VP3","pmid":null,"query_target_label":"Prolyl endopeptidase FAP","relation":null,"type":"Kd","units":"nM","units_provenance":"BindingDB REST affinity/cutoff convention","value":"0.005"},"molecule":{"canonical_smiles":"OC[C@H]1CCN(C1)c1ccc2nccc(C(=O)NCC(=O)N3CSC[C@H]3C#N)c2c1 |r|","molecule_type":"small molecule","preferred_name":null,"source_molecule_id":"622261","standard_inchi":null,"standard_inchi_key":null},"query_ids":["BDB-PDB-6Y0F","BDB-PDB-9DVR","BDB-UNI-Q12884"],"source":"BindingDB","source_target_id":"Q12884","target_id":"T-ENSG00000078098","target_resolution":"exact-uniprot-query-or-100-percent-pdb-sequence-match","uniprot_accession":"Q12884"},{"claim_ceiling":"measured BindingDB target affinity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":"This target contains an intracellular catalytic domain; kinase/catalytic inhibitors must not be treated as extracellular surface-site evidence.","matched_actionable_site_ids":[],"reason":"BindingDB used the deposited PDB as a target/sequence lookup. The returned affinity does not prove that the ligand occupies the deposited extracellular site.","state":"pdb-indexed-target-match-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"MET","interaction_id":"KCI-BINDINGDB-e5a7cd86571d5244","measurement":{"activity_id":null,"doi":"10.7270/Q23X8C0F","pmid":null,"query_target_label":"Hepatocyte growth factor receptor","relation":null,"type":"IC50","units":"nM","units_provenance":"BindingDB REST affinity/cutoff convention","value":"0.001"},"molecule":{"canonical_smiles":"CNC(=S)c1ccc(cc1F)-c1cnc2ncc(Cc3cc(Cl)c4ncccc4c3)n2n1","molecule_type":"small molecule","preferred_name":null,"source_molecule_id":"694660","standard_inchi":null,"standard_inchi_key":null},"query_ids":["BDB-PDB-4K3J","BDB-UNI-P08581"],"source":"BindingDB","source_target_id":"P08581","target_id":"T-ENSG00000105976","target_resolution":"exact-uniprot-query-or-100-percent-pdb-sequence-match","uniprot_accession":"P08581"},{"claim_ceiling":"measured BindingDB target affinity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":"This target contains an intracellular catalytic domain; kinase/catalytic inhibitors must not be treated as extracellular surface-site evidence.","matched_actionable_site_ids":[],"reason":"BindingDB used the deposited PDB as a target/sequence lookup. The returned affinity does not prove that the ligand occupies the deposited extracellular site.","state":"pdb-indexed-target-match-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"MET","interaction_id":"KCI-BINDINGDB-e5c5966f67a1df06","measurement":{"activity_id":null,"doi":"10.7270/Q23X8C0F","pmid":null,"query_target_label":"Hepatocyte growth factor receptor","relation":null,"type":"IC50","units":"nM","units_provenance":"BindingDB REST affinity/cutoff convention","value":"0.002"},"molecule":{"canonical_smiles":"CNC(=S)c1ccc(cc1F)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1","molecule_type":"small molecule","preferred_name":null,"source_molecule_id":"694646","standard_inchi":null,"standard_inchi_key":null},"query_ids":["BDB-PDB-4K3J","BDB-UNI-P08581"],"source":"BindingDB","source_target_id":"P08581","target_id":"T-ENSG00000105976","target_resolution":"exact-uniprot-query-or-100-percent-pdb-sequence-match","uniprot_accession":"P08581"},{"claim_ceiling":"measured BindingDB target affinity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":null,"matched_actionable_site_ids":[],"reason":"BindingDB used the deposited PDB as a target/sequence lookup. The returned affinity does not prove that the ligand occupies the deposited extracellular site.","state":"pdb-indexed-target-match-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"FAP","interaction_id":"KCI-BINDINGDB-e89a96026ae4d4d1","measurement":{"activity_id":null,"doi":"10.7270/Q21R6VP3","pmid":null,"query_target_label":"Prolyl endopeptidase FAP","relation":null,"type":"Kd","units":"nM","units_provenance":"BindingDB REST affinity/cutoff convention","value":"0.008"},"molecule":{"canonical_smiles":"CC(C)C1(O)CCN(CC1)c1ccc2nccc(C(=O)NCC(=O)N3CSC[C@H]3C#N)c2c1 |r|","molecule_type":"small molecule","preferred_name":null,"source_molecule_id":"622232","standard_inchi":null,"standard_inchi_key":null},"query_ids":["BDB-PDB-6Y0F","BDB-PDB-9DVR","BDB-UNI-Q12884"],"source":"BindingDB","source_target_id":"Q12884","target_id":"T-ENSG00000078098","target_resolution":"exact-uniprot-query-or-100-percent-pdb-sequence-match","uniprot_accession":"Q12884"},{"claim_ceiling":"measured BindingDB target affinity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":null,"matched_actionable_site_ids":[],"reason":"BindingDB used the deposited PDB as a target/sequence lookup. The returned affinity does not prove that the ligand occupies the deposited extracellular site.","state":"pdb-indexed-target-match-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"FAP","interaction_id":"KCI-BINDINGDB-fad46cd8f75e9711","measurement":{"activity_id":null,"doi":"10.7270/Q21R6VP3","pmid":null,"query_target_label":"Prolyl endopeptidase FAP","relation":null,"type":"Kd","units":"nM","units_provenance":"BindingDB REST affinity/cutoff convention","value":"0.009"},"molecule":{"canonical_smiles":"CC1(F)CN(C1)c1ccc2nccc(C(=O)NCC(=O)N3CSC[C@H]3C#N)c2c1 |r|","molecule_type":"small molecule","preferred_name":null,"source_molecule_id":"622064","standard_inchi":null,"standard_inchi_key":null},"query_ids":["BDB-PDB-6Y0F","BDB-PDB-9DVR","BDB-UNI-Q12884"],"source":"BindingDB","source_target_id":"Q12884","target_id":"T-ENSG00000078098","target_resolution":"exact-uniprot-query-or-100-percent-pdb-sequence-match","uniprot_accession":"Q12884"},{"claim_ceiling":"measured BindingDB target affinity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":null,"matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"NT5E","interaction_id":"KCI-BINDINGDB-fb5a19e615ed96ca","measurement":{"activity_id":null,"doi":"10.1021/acs.jmedchem.9b01611","pmid":"32045236","query_target_label":"5'-nucleotidase","relation":null,"type":"Ki","units":"nM","units_provenance":"BindingDB REST affinity/cutoff convention","value":"0.005000"},"molecule":{"canonical_smiles":"C[C@@H](c1ccccc1F)Nc2cc(nc3c2cnn3[C@H]4[C@@H]([C@@H]([C@H](O4)COP(=O)(CP(=O)(O)O)O)O)O)Cl","molecule_type":"small molecule","preferred_name":null,"source_molecule_id":"50527134","standard_inchi":null,"standard_inchi_key":null},"query_ids":["BDB-UNI-P21589"],"source":"BindingDB","source_target_id":"P21589","target_id":"T-ENSG00000135318","target_resolution":"exact-uniprot-query-or-100-percent-pdb-sequence-match","uniprot_accession":"P21589"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":"This target contains an intracellular catalytic domain; kinase/catalytic inhibitors must not be treated as extracellular surface-site evidence.","matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"EGFR","interaction_id":"KCI-CHEMBL-1043415","measurement":{"activity_id":1043415,"assay_chembl_id":"CHEMBL683040","assay_description":"Inhibition of tyrosine kinase activity of Epidermal growth factor receptor from human A431 carcinoma cells","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL1129035","document_year":1996,"pchembl_value":"11.00","relation":"=","type":"IC50","units":"nM","value":"0.01"},"molecule":{"canonical_smiles":"Cn1cnc2cc3ncnc(Nc4cccc(Br)c4)c3cc21","molecule_type":"Small molecule","preferred_name":null,"source_molecule_id":"CHEMBL176582","standard_inchi":"InChI=1S/C16H12BrN5/c1-22-9-20-14-7-13-12(6-15(14)22)16(19-8-18-13)21-11-4-2-3-10(17)5-11/h2-9H,1H3,(H,18,19,21)","standard_inchi_key":"LQIKOEJHMCCOSP-UHFFFAOYSA-N"},"query_ids":["CH-TARGET-P00533","CH-ACT-CHEMBL203","CH-MOL-CHEMBL176582"],"source":"ChEMBL","source_target_id":"CHEMBL203","target_id":"T-ENSG00000146648","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"P00533"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":"This target contains an intracellular catalytic domain; kinase/catalytic inhibitors must not be treated as extracellular surface-site evidence.","matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"MET","interaction_id":"KCI-CHEMBL-15614613","measurement":{"activity_id":15614613,"assay_chembl_id":"CHEMBL3583343","assay_description":"Inhibition of C-Met (unknown origin) using polu (Glu,Tyr)4:1 substrate after 30 mins incubation by multi-well spectrophotometry","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL3580555","document_year":2015,"pchembl_value":"9.89","relation":"=","type":"IC50","units":"nM","value":"0.13"},"molecule":{"canonical_smiles":"CNC(=O)c1ccc(-c2cnc3nnc(Cc4ccc5ncccc5c4)n3n2)cc1F","molecule_type":"Small molecule","preferred_name":null,"source_molecule_id":"CHEMBL3582305","standard_inchi":"InChI=1S/C22H16FN7O/c1-24-21(31)16-6-5-15(11-17(16)23)19-12-26-22-28-27-20(30(22)29-19)10-13-4-7-18-14(9-13)3-2-8-25-18/h2-9,11-12H,10H2,1H3,(H,24,31)","standard_inchi_key":"AXBANCDWRYXEBP-UHFFFAOYSA-N"},"query_ids":["CH-TARGET-P08581","CH-ACT-CHEMBL3717","CH-MOL-CHEMBL3582305"],"source":"ChEMBL","source_target_id":"CHEMBL3717","target_id":"T-ENSG00000105976","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"P08581"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":null,"matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"CD47","interaction_id":"KCI-CHEMBL-16668997","measurement":{"activity_id":16668997,"assay_chembl_id":"CHEMBL3855090","assay_description":"Binding affinity to CD47 receptor in human NT.115-labeled MEC1 cell membranes after 5 mins by MST assay","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL3853322","document_year":2016,"pchembl_value":"5.52","relation":"=","type":"Kd","units":"nM","value":"3040.0"},"molecule":{"canonical_smiles":"CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCCCN)C(C)C)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)O","molecule_type":"Protein","preferred_name":null,"source_molecule_id":"CHEMBL3971661","standard_inchi":"InChI=1S/C68H105N17O12S/c1-40(2)56(65(94)79-51(30-35-98-5)61(90)83-55(38-44-39-76-48-22-10-9-20-46(44)48)63(92)78-49(23-12-15-32-70)59(88)80-52(67(96)97)24-13-16-33-71)85-66(95)57(41(3)4)84-64(93)54(37-43-26-28-45(86)29-27-43)82-62(91)53(36-42-18-7-6-8-19-42)81-60(89)50(25-17-34-75-68(73)74)77-58(87)47(72)21-11-14-31-69/h6-10,18-20,22,26-29,39-41,47,49-57,76,86H,11-17,21,23-25,30-38,69-72H2,1-5H3,(H,77,87)(H,78,92)(H,79,94)(H,80,88)(H,81,89)(H,82,91)(H,83,90)(H,84,93)(H,85,95)(H,96,97)(H4,73,74,75)/t47-,49+,50+,51+,52-,53+,54+,55+,56+,57+/m1/s1","standard_inchi_key":"XEMLJJZYMPZGBS-UEUNBRMZSA-N"},"query_ids":["CH-TARGET-Q08722","CH-ACT-CHEMBL3714583","CH-MOL-CHEMBL3971661"],"source":"ChEMBL","source_target_id":"CHEMBL3714583","target_id":"T-ENSG00000196776","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"Q08722"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":null,"matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"CD47","interaction_id":"KCI-CHEMBL-16668998","measurement":{"activity_id":16668998,"assay_chembl_id":"CHEMBL3855090","assay_description":"Binding affinity to CD47 receptor in human NT.115-labeled MEC1 cell membranes after 5 mins by MST assay","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL3853322","document_year":2016,"pchembl_value":"5.92","relation":"=","type":"Kd","units":"nM","value":"1200.0"},"molecule":{"canonical_smiles":"CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(C)=O)C(C)C)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O","molecule_type":"Protein","preferred_name":null,"source_molecule_id":"CHEMBL3891508","standard_inchi":"InChI=1S/C70H108N18O12S/c1-41(2)58(68(99)83-54(31-36-101-6)64(95)86-57(39-46-40-78-49-22-11-10-21-48(46)49)66(97)82-52(25-14-17-34-73)62(93)80-50(60(74)91)23-12-15-32-71)88-69(100)59(42(3)4)87-67(98)56(38-45-27-29-47(90)30-28-45)85-65(96)55(37-44-19-8-7-9-20-44)84-63(94)53(26-18-35-77-70(75)76)81-61(92)51(79-43(5)89)24-13-16-33-72/h7-11,19-22,27-30,40-42,50-59,78,90H,12-18,23-26,31-39,71-73H2,1-6H3,(H2,74,91)(H,79,89)(H,80,93)(H,81,92)(H,82,97)(H,83,99)(H,84,94)(H,85,96)(H,86,95)(H,87,98)(H,88,100)(H4,75,76,77)/t50-,51-,52-,53-,54-,55-,56-,57-,58-,59-/m0/s1","standard_inchi_key":"YSBLDQMUSOQJJY-PVGXKDMPSA-N"},"query_ids":["CH-TARGET-Q08722","CH-ACT-CHEMBL3714583","CH-MOL-CHEMBL3891508"],"source":"ChEMBL","source_target_id":"CHEMBL3714583","target_id":"T-ENSG00000196776","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"Q08722"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":null,"matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"CD47","interaction_id":"KCI-CHEMBL-16668999","measurement":{"activity_id":16668999,"assay_chembl_id":"CHEMBL3855090","assay_description":"Binding affinity to CD47 receptor in human NT.115-labeled MEC1 cell membranes after 5 mins by MST assay","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL3853322","document_year":2016,"pchembl_value":"5.64","relation":"=","type":"Kd","units":"nM","value":"2280.0"},"molecule":{"canonical_smiles":"CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCCN)C(C)C)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O","molecule_type":"Protein","preferred_name":null,"source_molecule_id":"CHEMBL3974452","standard_inchi":"InChI=1S/C68H105N17O12S/c1-40(2)56(65(94)79-51(30-35-98-5)61(90)83-55(38-44-39-76-48-22-10-9-20-46(44)48)63(92)78-49(23-12-15-32-70)59(88)80-52(67(96)97)24-13-16-33-71)85-66(95)57(41(3)4)84-64(93)54(37-43-26-28-45(86)29-27-43)82-62(91)53(36-42-18-7-6-8-19-42)81-60(89)50(25-17-34-75-68(73)74)77-58(87)47(72)21-11-14-31-69/h6-10,18-20,22,26-29,39-41,47,49-57,76,86H,11-17,21,23-25,30-38,69-72H2,1-5H3,(H,77,87)(H,78,92)(H,79,94)(H,80,88)(H,81,89)(H,82,91)(H,83,90)(H,84,93)(H,85,95)(H,96,97)(H4,73,74,75)/t47-,49-,50-,51-,52-,53-,54-,55-,56-,57-/m0/s1","standard_inchi_key":"XEMLJJZYMPZGBS-ITJFCMOYSA-N"},"query_ids":["CH-TARGET-Q08722","CH-ACT-CHEMBL3714583","CH-MOL-CHEMBL3974452"],"source":"ChEMBL","source_target_id":"CHEMBL3714583","target_id":"T-ENSG00000196776","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"Q08722"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":null,"matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"CD47","interaction_id":"KCI-CHEMBL-16669000","measurement":{"activity_id":16669000,"assay_chembl_id":"CHEMBL3855090","assay_description":"Binding affinity to CD47 receptor in human NT.115-labeled MEC1 cell membranes after 5 mins by MST assay","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL3853322","document_year":2016,"pchembl_value":"6.11","relation":"=","type":"Kd","units":"nM","value":"771.0"},"molecule":{"canonical_smiles":"CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(=N)N)NC(C)=O)C(C)C)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(N)=O","molecule_type":"Protein","preferred_name":null,"source_molecule_id":"CHEMBL3946082","standard_inchi":"InChI=1S/C58H84N14O10S/c1-33(2)48(56(81)67-44(25-28-83-6)52(77)70-47(31-38-32-64-41-18-11-10-17-40(38)41)54(79)66-42(50(60)75)19-12-13-26-59)72-57(82)49(34(3)4)71-55(80)46(30-37-21-23-39(74)24-22-37)69-53(78)45(29-36-15-8-7-9-16-36)68-51(76)43(65-35(5)73)20-14-27-63-58(61)62/h7-11,15-18,21-24,32-34,42-49,64,74H,12-14,19-20,25-31,59H2,1-6H3,(H2,60,75)(H,65,73)(H,66,79)(H,67,81)(H,68,76)(H,69,78)(H,70,77)(H,71,80)(H,72,82)(H4,61,62,63)/t42-,43-,44-,45-,46-,47-,48-,49-/m0/s1","standard_inchi_key":"FKPSPUPLFAWXTN-XJIZABAQSA-N"},"query_ids":["CH-TARGET-Q08722","CH-ACT-CHEMBL3714583","CH-MOL-CHEMBL3946082"],"source":"ChEMBL","source_target_id":"CHEMBL3714583","target_id":"T-ENSG00000196776","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"Q08722"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":"This target contains an intracellular catalytic domain; kinase/catalytic inhibitors must not be treated as extracellular surface-site evidence.","matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"MET","interaction_id":"KCI-CHEMBL-17688600","measurement":{"activity_id":17688600,"assay_chembl_id":"CHEMBL3705882","assay_description":"In Vitro Assay: A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward primer 5'-ATTGACGGATCCATGCTAAATCCAGAGCTGGTCCAGGCA-3' (SEQ ID NO. 1) and reverse primer 5'-ACAACAGAATTCAATACGGAGCGACACATTTTACGTT-3' (SEQ ID NO. 2). The PCR product is cloned into a modified pFastBac 1 expression vector (harboring the gene for S. japonicum glutathione S-transferase immediately upstream of the multiple cloning site) using standard molecular biological techniques. The GST-c-Met kinase domain fusion (GST-Met) gene is transposed into full-length baculovirus DNA using the BacToBac system (Invitrogen). High5 cells are infected with the recombinant baculovirus for 72 h at 27 C. The infected cells are harvested by centrifugation and the pellet is stored at -80 C. The pellet is resuspended in buffer A (50 mM HEPES, pH 8.0, 0.25 M NaCl, 10 mM 2-mercaptoethanol, 10% (w/v) glycerol, 0.5% (v/v) protease.","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL3639266","document_year":2015,"pchembl_value":"10.00","relation":"=","type":"Ki","units":"nM","value":"0.1"},"molecule":{"canonical_smiles":"Fc1cc(F)cc(-c2ccc3nnc(CNc4ccnc5cc(OCCn6cncn6)cnc45)n3n2)c1","molecule_type":"Small molecule","preferred_name":null,"source_molecule_id":"CHEMBL3668200","standard_inchi":"InChI=1S/C24H18F2N10O/c25-16-7-15(8-17(26)9-16)19-1-2-22-32-33-23(36(22)34-19)12-29-20-3-4-28-21-10-18(11-30-24(20)21)37-6-5-35-14-27-13-31-35/h1-4,7-11,13-14H,5-6,12H2,(H,28,29)","standard_inchi_key":"YWAKXUWRHLXYJM-UHFFFAOYSA-N"},"query_ids":["CH-TARGET-P08581","CH-ACT-CHEMBL3717","CH-MOL-CHEMBL3668200"],"source":"ChEMBL","source_target_id":"CHEMBL3717","target_id":"T-ENSG00000105976","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"P08581"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":null,"matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"CD47","interaction_id":"KCI-CHEMBL-19306596","measurement":{"activity_id":19306596,"assay_chembl_id":"CHEMBL4415101","assay_description":"Binding affinity to CD47 in biotinylated human MEC1 cell membranes by biolayer interferometry","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL4414552","document_year":2019,"pchembl_value":"6.72","relation":"=","type":"Kd","units":"nM","value":"190.0"},"molecule":{"canonical_smiles":"CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](CCCCN)NC(=O)CCCCn1cc(CN(Cc2cn(CCCCC(=O)N[C@H](CCCCN)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCC)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)O)C(C)C)C(C)C)nn2)Cc2cn(CCCCC(=O)N[C@H](CCCCN)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCC)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)O)C(C)C)C(C)C)nn2)nn1)C(C)C)C(C)C)C(=O)N[C@H](CN[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)O)Cc1c[nH]c2ccccc12","molecule_type":"Unknown","preferred_name":null,"source_molecule_id":"CHEMBL4522427","standard_inchi":"InChI=1S/C234H359N61O38/c1-19-22-76-172(204(303)257-158(130-155-133-253-168-79-37-34-73-165(155)168)136-256-171(82-40-52-109-235)203(302)266-180(229(328)329)88-46-58-115-241)263-220(319)197(143(4)5)280-223(322)200(146(10)11)277-214(313)186(127-152-97-103-162(296)104-98-152)269-209(308)183(124-149-67-28-25-29-68-149)274-217(316)191(91-64-118-250-232(244)245)289(16)226(325)177(85-43-55-112-238)258-194(299)94-49-61-121-293-140-159(283-286-293)137-292(138-160-141-294(287-284-160)122-62-50-95-195(300)259-178(86-44-56-113-239)227(326)290(17)192(92-65-119-251-233(246)247)218(317)275-184(125-150-69-30-26-31-70-150)210(309)270-187(128-153-99-105-163(297)106-100-153)215(314)278-201(147(12)13)224(323)281-198(144(6)7)221(320)264-173(77-23-20-2)207(306)272-189(131-156-134-254-169-80-38-35-74-166(156)169)212(311)261-175(83-41-53-110-236)205(304)267-181(230(330)331)89-47-59-116-242)139-161-142-295(288-285-161)123-63-51-96-196(301)260-179(87-45-57-114-240)228(327)291(18)193(93-66-120-252-234(248)249)219(318)276-185(126-151-71-32-27-33-72-151)211(310)271-188(129-154-101-107-164(298)108-102-154)216(315)279-202(148(14)15)225(324)282-199(145(8)9)222(321)265-174(78-24-21-3)208(307)273-190(132-157-135-255-170-81-39-36-75-167(157)170)213(312)262-176(84-42-54-111-237)206(305)268-182(231(332)333)90-48-60-117-243/h25-39,67-75,79-81,97-108,133-135,140-148,158,171-193,197-202,253-256,296-298H,19-24,40-66,76-78,82-96,109-132,136-139,235-243H2,1-18H3,(H,257,303)(H,258,299)(H,259,300)(H,260,301)(H,261,311)(H,262,312)(H,263,319)(H,264,320)(H,265,321)(H,266,302)(H,267,304)(H,268,305)(H,269,308)(H,270,309)(H,271,310)(H,272,306)(H,273,307)(H,274,316)(H,275,317)(H,276,318)(H,277,313)(H,278,314)(H,279,315)(H,280,322)(H,281,323)(H,282,324)(H,328,329)(H,330,331)(H,332,333)(H4,244,245,250)(H4,246,247,251)(H4,248,249,252)/t158-,171-,172-,173-,174-,175-,176-,177+,178+,179+,180+,181+,182+,183-,184-,185-,186-,187-,188-,189-,190-,191-,192-,193-,197-,198-,199-,200-,201-,202-/m0/s1","standard_inchi_key":"BFKUAGFDBTUEHS-MCZOLVINSA-N"},"query_ids":["CH-TARGET-Q08722","CH-ACT-CHEMBL3714583","CH-MOL-CHEMBL4522427"],"source":"ChEMBL","source_target_id":"CHEMBL3714583","target_id":"T-ENSG00000196776","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"Q08722"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":null,"matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"NT5E","interaction_id":"KCI-CHEMBL-22396873","measurement":{"activity_id":22396873,"assay_chembl_id":"CHEMBL4668688","assay_description":"Inhibition of CD73 in human CD8-positive T cells using AMP as substrate preincubated for 60 mins followed by substrate addition and measured after 2.5 hrs by PiColorLock gold reagent based colorimetric assay","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL4665688","document_year":2020,"pchembl_value":"11.00","relation":"=","type":"IC50","units":"nM","value":"0.01"},"molecule":{"canonical_smiles":"C[C@H](Nc1cc(Cl)nc2c1cnn2[C@@H]1O[C@H](COP(=O)(O)CP(=O)(O)O)[C@@H](O)[C@H]1O)c1ccc(F)cc1","molecule_type":"Unknown","preferred_name":null,"source_molecule_id":"CHEMBL4761506","standard_inchi":"InChI=1S/C20H24ClFN4O9P2/c1-10(11-2-4-12(22)5-3-11)24-14-6-16(21)25-19-13(14)7-23-26(19)20-18(28)17(27)15(35-20)8-34-37(32,33)9-36(29,30)31/h2-7,10,15,17-18,20,27-28H,8-9H2,1H3,(H,24,25)(H,32,33)(H2,29,30,31)/t10-,15+,17+,18+,20+/m0/s1","standard_inchi_key":"ZOJVDXWVVGFWSE-KCVUFLITSA-N"},"query_ids":["CH-TARGET-P21589","CH-ACT-CHEMBL5957","CH-MOL-CHEMBL4761506"],"source":"ChEMBL","source_target_id":"CHEMBL5957","target_id":"T-ENSG00000135318","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"P21589"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":null,"matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"NT5E","interaction_id":"KCI-CHEMBL-22396878","measurement":{"activity_id":22396878,"assay_chembl_id":"CHEMBL4668690","assay_description":"Inhibition of CD73 in human PBMC using AMP as substrate preincubated for 60 mins followed by substrate addition and measured after 2.5 hrs by PiColorLock gold reagent based colorimetric assay","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL4665688","document_year":2020,"pchembl_value":"10.96","relation":"=","type":"IC50","units":"nM","value":"0.011"},"molecule":{"canonical_smiles":"C[C@H](Nc1cc(Cl)nc2c1cnn2[C@@H]1O[C@H](COP(=O)(O)CP(=O)(O)O)[C@@H](O)[C@H]1O)c1ccccc1F","molecule_type":"Small molecule","preferred_name":"QUEMLICLUSTAT","source_molecule_id":"CHEMBL4471306","standard_inchi":"InChI=1S/C20H24ClFN4O9P2/c1-10(11-4-2-3-5-13(11)22)24-14-6-16(21)25-19-12(14)7-23-26(19)20-18(28)17(27)15(35-20)8-34-37(32,33)9-36(29,30)31/h2-7,10,15,17-18,20,27-28H,8-9H2,1H3,(H,24,25)(H,32,33)(H2,29,30,31)/t10-,15+,17+,18+,20+/m0/s1","standard_inchi_key":"MFYLCAMJNGIULC-KCVUFLITSA-N"},"query_ids":["CH-TARGET-P21589","CH-ACT-CHEMBL5957","CH-MOL-CHEMBL4471306"],"source":"ChEMBL","source_target_id":"CHEMBL5957","target_id":"T-ENSG00000135318","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"P21589"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":null,"matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"FAP","interaction_id":"KCI-CHEMBL-23308620","measurement":{"activity_id":23308620,"assay_chembl_id":"CHEMBL4843582","assay_description":"Inhibition of SF-tagged FAP (unknown origin) expressed in Drosophila S2 cells using fluorogenic substrate by spectrometric analysis","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL4842347","document_year":2021,"pchembl_value":"9.74","relation":"=","type":"IC50","units":"nM","value":"0.18"},"molecule":{"canonical_smiles":"COc1ccc(CNC(=O)C(=O)[C@@H]2CCCN2C(=O)CNC(=O)c2ccnc3ccccc23)cc1","molecule_type":"Unknown","preferred_name":null,"source_molecule_id":"CHEMBL4864809","standard_inchi":"InChI=1S/C26H26N4O5/c1-35-18-10-8-17(9-11-18)15-28-26(34)24(32)22-7-4-14-30(22)23(31)16-29-25(33)20-12-13-27-21-6-3-2-5-19(20)21/h2-3,5-6,8-13,22H,4,7,14-16H2,1H3,(H,28,34)(H,29,33)/t22-/m0/s1","standard_inchi_key":"MMUDHJFHAAEJPX-QFIPXVFZSA-N"},"query_ids":["CH-TARGET-Q12884","CH-ACT-CHEMBL4683","CH-MOL-CHEMBL4864809"],"source":"ChEMBL","source_target_id":"CHEMBL4683","target_id":"T-ENSG00000078098","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"Q12884"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":null,"matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"FAP","interaction_id":"KCI-CHEMBL-23308621","measurement":{"activity_id":23308621,"assay_chembl_id":"CHEMBL4843582","assay_description":"Inhibition of SF-tagged FAP (unknown origin) expressed in Drosophila S2 cells using fluorogenic substrate by spectrometric analysis","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL4842347","document_year":2021,"pchembl_value":"10.05","relation":"=","type":"IC50","units":"nM","value":"0.089"},"molecule":{"canonical_smiles":"COc1ccc(CNC(=O)C(=O)[C@@H]2CCCN2C(=O)CNC(=O)c2ccnc3ccccc23)cc1OC","molecule_type":"Unknown","preferred_name":null,"source_molecule_id":"CHEMBL4877950","standard_inchi":"InChI=1S/C27H28N4O6/c1-36-22-10-9-17(14-23(22)37-2)15-29-27(35)25(33)21-8-5-13-31(21)24(32)16-30-26(34)19-11-12-28-20-7-4-3-6-18(19)20/h3-4,6-7,9-12,14,21H,5,8,13,15-16H2,1-2H3,(H,29,35)(H,30,34)/t21-/m0/s1","standard_inchi_key":"QYNUSKJDVJHHFJ-NRFANRHFSA-N"},"query_ids":["CH-TARGET-Q12884","CH-ACT-CHEMBL4683","CH-MOL-CHEMBL4877950"],"source":"ChEMBL","source_target_id":"CHEMBL4683","target_id":"T-ENSG00000078098","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"Q12884"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":null,"matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"FAP","interaction_id":"KCI-CHEMBL-23308626","measurement":{"activity_id":23308626,"assay_chembl_id":"CHEMBL4843582","assay_description":"Inhibition of SF-tagged FAP (unknown origin) expressed in Drosophila S2 cells using fluorogenic substrate by spectrometric analysis","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL4842347","document_year":2021,"pchembl_value":"9.72","relation":"=","type":"IC50","units":"nM","value":"0.19"},"molecule":{"canonical_smiles":"COc1ccc(CCNC(=O)C(=O)[C@@H]2CCCN2C(=O)CNC(=O)c2ccnc3ccccc23)cc1OC","molecule_type":"Unknown","preferred_name":null,"source_molecule_id":"CHEMBL4853661","standard_inchi":"InChI=1S/C28H30N4O6/c1-37-23-10-9-18(16-24(23)38-2)11-13-30-28(36)26(34)22-8-5-15-32(22)25(33)17-31-27(35)20-12-14-29-21-7-4-3-6-19(20)21/h3-4,6-7,9-10,12,14,16,22H,5,8,11,13,15,17H2,1-2H3,(H,30,36)(H,31,35)/t22-/m0/s1","standard_inchi_key":"HPIBKLMNZIHAGI-QFIPXVFZSA-N"},"query_ids":["CH-TARGET-Q12884","CH-ACT-CHEMBL4683","CH-MOL-CHEMBL4853661"],"source":"ChEMBL","source_target_id":"CHEMBL4683","target_id":"T-ENSG00000078098","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"Q12884"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":null,"matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"FAP","interaction_id":"KCI-CHEMBL-23308637","measurement":{"activity_id":23308637,"assay_chembl_id":"CHEMBL4843582","assay_description":"Inhibition of SF-tagged FAP (unknown origin) expressed in Drosophila S2 cells using fluorogenic substrate by spectrometric analysis","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL4842347","document_year":2021,"pchembl_value":"9.89","relation":"=","type":"IC50","units":"nM","value":"0.13"},"molecule":{"canonical_smiles":"CC(C)(C)OC(=O)CNC(=O)C(=O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12","molecule_type":"Unknown","preferred_name":null,"source_molecule_id":"CHEMBL4878759","standard_inchi":"InChI=1S/C24H28N4O6/c1-24(2,3)34-20(30)14-27-23(33)21(31)18-9-6-12-28(18)19(29)13-26-22(32)16-10-11-25-17-8-5-4-7-15(16)17/h4-5,7-8,10-11,18H,6,9,12-14H2,1-3H3,(H,26,32)(H,27,33)/t18-/m0/s1","standard_inchi_key":"RTTFNCLHEGUOEO-SFHVURJKSA-N"},"query_ids":["CH-TARGET-Q12884","CH-ACT-CHEMBL4683","CH-MOL-CHEMBL4878759"],"source":"ChEMBL","source_target_id":"CHEMBL4683","target_id":"T-ENSG00000078098","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"Q12884"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":"This target contains an intracellular catalytic domain; kinase/catalytic inhibitors must not be treated as extracellular surface-site evidence.","matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"MET","interaction_id":"KCI-CHEMBL-24687320","measurement":{"activity_id":24687320,"assay_chembl_id":"CHEMBL5104346","assay_description":"Inhibition of human recombinant c-MET in presence of ATP by HTRF assay","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL5104091","document_year":2021,"pchembl_value":"10.46","relation":"=","type":"IC50","units":"nM","value":"0.035"},"molecule":{"canonical_smiles":"O=c1ccc(-c2cccnc2)nn1CC1CN(c2ncc(-c3cnn(C4CCNCC4)c3)cn2)CCO1","molecule_type":null,"preferred_name":null,"source_molecule_id":"CHEMBL5174958","standard_inchi":"InChI=1S/C26H29N9O2/c36-25-4-3-24(19-2-1-7-28-12-19)32-35(25)18-23-17-33(10-11-37-23)26-29-13-20(14-30-26)21-15-31-34(16-21)22-5-8-27-9-6-22/h1-4,7,12-16,22-23,27H,5-6,8-11,17-18H2","standard_inchi_key":"KCVROOBNYZLDFN-UHFFFAOYSA-N"},"query_ids":["CH-TARGET-P08581","CH-ACT-CHEMBL3717","CH-MOL-CHEMBL5174958"],"source":"ChEMBL","source_target_id":"CHEMBL3717","target_id":"T-ENSG00000105976","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"P08581"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":"This target contains an intracellular catalytic domain; kinase/catalytic inhibitors must not be treated as extracellular surface-site evidence.","matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"MET","interaction_id":"KCI-CHEMBL-24687321","measurement":{"activity_id":24687321,"assay_chembl_id":"CHEMBL5104346","assay_description":"Inhibition of human recombinant c-MET in presence of ATP by HTRF assay","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL5104091","document_year":2021,"pchembl_value":"10.72","relation":"=","type":"IC50","units":"nM","value":"0.019"},"molecule":{"canonical_smiles":"Cn1cc(-c2ccc(=O)n(CC3CN(c4ncc(OCC5CCNCC5)cn4)CCO3)n2)cn1","molecule_type":null,"preferred_name":null,"source_molecule_id":"CHEMBL5184459","standard_inchi":"InChI=1S/C23H30N8O3/c1-29-13-18(10-27-29)21-2-3-22(32)31(28-21)15-20-14-30(8-9-33-20)23-25-11-19(12-26-23)34-16-17-4-6-24-7-5-17/h2-3,10-13,17,20,24H,4-9,14-16H2,1H3","standard_inchi_key":"NHZVEUDKERINQO-UHFFFAOYSA-N"},"query_ids":["CH-TARGET-P08581","CH-ACT-CHEMBL3717","CH-MOL-CHEMBL5184459"],"source":"ChEMBL","source_target_id":"CHEMBL3717","target_id":"T-ENSG00000105976","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"P08581"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":"This target contains an intracellular catalytic domain; kinase/catalytic inhibitors must not be treated as extracellular surface-site evidence.","matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"ERBB2","interaction_id":"KCI-CHEMBL-24962907","measurement":{"activity_id":24962907,"assay_chembl_id":"CHEMBL5216307","assay_description":"Inhibition of HER2 (unknown origin) incubated for 1 hr in presence of ATP by Kinase-Glo Plus luminescence kinase assay","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL5214926","document_year":2022,"pchembl_value":"9.85","relation":"=","type":"IC50","units":"nM","value":"0.14"},"molecule":{"canonical_smiles":"N#Cc1c(NC(=O)CNc2n[nH]c3ncccc23)sc2c1CCCC2","molecule_type":null,"preferred_name":null,"source_molecule_id":"CHEMBL5221067","standard_inchi":"InChI=1S/C17H16N6OS/c18-8-12-10-4-1-2-6-13(10)25-17(12)21-14(24)9-20-16-11-5-3-7-19-15(11)22-23-16/h3,5,7H,1-2,4,6,9H2,(H,21,24)(H2,19,20,22,23)","standard_inchi_key":"IBVURLSKTNUMDI-UHFFFAOYSA-N"},"query_ids":["CH-TARGET-P04626","CH-ACT-CHEMBL1824","CH-MOL-CHEMBL5221067"],"source":"ChEMBL","source_target_id":"CHEMBL1824","target_id":"T-ENSG00000141736","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"P04626"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":"This target contains an intracellular catalytic domain; kinase/catalytic inhibitors must not be treated as extracellular surface-site evidence.","matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"ERBB2","interaction_id":"KCI-CHEMBL-24962908","measurement":{"activity_id":24962908,"assay_chembl_id":"CHEMBL5216307","assay_description":"Inhibition of HER2 (unknown origin) incubated for 1 hr in presence of ATP by Kinase-Glo Plus luminescence kinase assay","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL5214926","document_year":2022,"pchembl_value":"10.22","relation":"=","type":"IC50","units":"nM","value":"0.06"},"molecule":{"canonical_smiles":"Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1","molecule_type":"Small molecule","preferred_name":"IMATINIB","source_molecule_id":"CHEMBL941","standard_inchi":"InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)","standard_inchi_key":"KTUFNOKKBVMGRW-UHFFFAOYSA-N"},"query_ids":["CH-TARGET-P04626","CH-ACT-CHEMBL1824","CH-MOL-CHEMBL941"],"source":"ChEMBL","source_target_id":"CHEMBL1824","target_id":"T-ENSG00000141736","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"P04626"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":"This target contains an intracellular catalytic domain; kinase/catalytic inhibitors must not be treated as extracellular surface-site evidence.","matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"EGFR","interaction_id":"KCI-CHEMBL-25098086","measurement":{"activity_id":25098086,"assay_chembl_id":"CHEMBL5260456","assay_description":"Inhibition of EGFR L858R mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition for 15 mins by HTRF assay","assay_type":"B","assay_variant_accession":"P00533","assay_variant_mutation":"L858R","document_chembl_id":"CHEMBL5257147","document_year":2023,"pchembl_value":"11.00","relation":"=","type":"IC50","units":"nM","value":"0.01"},"molecule":{"canonical_smiles":"C=CC(=O)Nc1cc(Nc2ncc(C(=O)OC(C)C)c(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C","molecule_type":"Small molecule","preferred_name":"MOBOCERTINIB","source_molecule_id":"CHEMBL4650319","standard_inchi":"InChI=1S/C32H39N7O4/c1-9-29(40)34-24-16-25(28(42-8)17-27(24)38(6)15-14-37(4)5)35-32-33-18-22(31(41)43-20(2)3)30(36-32)23-19-39(7)26-13-11-10-12-21(23)26/h9-13,16-20H,1,14-15H2,2-8H3,(H,34,40)(H,33,35,36)","standard_inchi_key":"AZSRSNUQCUDCGG-UHFFFAOYSA-N"},"query_ids":["CH-TARGET-P00533","CH-ACT-CHEMBL203","CH-MOL-CHEMBL4650319"],"source":"ChEMBL","source_target_id":"CHEMBL203","target_id":"T-ENSG00000146648","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"P00533"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":"This target contains an intracellular catalytic domain; kinase/catalytic inhibitors must not be treated as extracellular surface-site evidence.","matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"MET","interaction_id":"KCI-CHEMBL-25106956","measurement":{"activity_id":25106956,"assay_chembl_id":"CHEMBL5263705","assay_description":"Inhibition of c-Met (unknown origin) using poly(Glu-Tyr) at 4:1 ratio as substrate in presence of ATP incubated for 60 mins by ELISA","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL5260829","document_year":2018,"pchembl_value":"9.92","relation":"=","type":"IC50","units":"nM","value":"0.12"},"molecule":{"canonical_smiles":"COc1ccc2c(OCc3nnc4ncc(-c5ccccc5)nn34)ccnc2c1","molecule_type":"Small molecule","preferred_name":null,"source_molecule_id":"CHEMBL3797911","standard_inchi":"InChI=1S/C21H16N6O2/c1-28-15-7-8-16-17(11-15)22-10-9-19(16)29-13-20-24-25-21-23-12-18(26-27(20)21)14-5-3-2-4-6-14/h2-12H,13H2,1H3","standard_inchi_key":"DYQKJQPOOQEANS-UHFFFAOYSA-N"},"query_ids":["CH-TARGET-P08581","CH-ACT-CHEMBL3717","CH-MOL-CHEMBL3797911"],"source":"ChEMBL","source_target_id":"CHEMBL3717","target_id":"T-ENSG00000105976","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"P08581"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":null,"matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"EPCAM","interaction_id":"KCI-CHEMBL-26218781","measurement":{"activity_id":26218781,"assay_chembl_id":"CHEMBL5651366","assay_description":"Binding affinity to human EPCAM incubated for 45 mins by Kinobead based pull down assay","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL5649169","document_year":2018,"pchembl_value":"9.33","relation":"=","type":"Kd","units":"nM","value":"0.472"},"molecule":{"canonical_smiles":"Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12","molecule_type":null,"preferred_name":null,"source_molecule_id":"CHEMBL5653589","standard_inchi":"InChI=1S/C26H20F3N7O/c1-15-8-9-16(25(37)31-19-7-3-6-18(12-19)26(27,28)29)11-21(15)32-23-20-14-36(2)35-24(20)34-22(33-23)17-5-4-10-30-13-17/h3-14H,1-2H3,(H,31,37)(H,32,33,34,35)","standard_inchi_key":"MWKSRKSEWLRPBL-UHFFFAOYSA-N"},"query_ids":["CH-TARGET-P16422","CH-ACT-CHEMBL3580493","CH-MOL-CHEMBL5653589"],"source":"ChEMBL","source_target_id":"CHEMBL3580493","target_id":"T-ENSG00000119888","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"P16422"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":"This target contains an intracellular catalytic domain; kinase/catalytic inhibitors must not be treated as extracellular surface-site evidence.","matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"ERBB2","interaction_id":"KCI-CHEMBL-27038390","measurement":{"activity_id":27038390,"assay_chembl_id":"CHEMBL5731752","assay_description":"SKBR3 Cell Viability Assay for Antibody-Polymer-Drug Conjugates: PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega Corp). Cells were plated in black walled 96-well plate and allowed to adhere overnight at 37° C. in a humidified atmosphere of 5% CO2. SKBR3 and were plated at a density of 5,000 cells per well. The next day the medium was replaced with 50 μL fresh medium and 50 μL of 2× stocks of PBD compounds or antibody-PBD conjugate were added to appropriate wells, mixed and incubated for 72 h. CellTiter-Glo® reagent was added to the wells at room temperature and the luminescent signal was measured after 10 min using a SpectraMax M5 plate reader (Molecular Devices). Dose response curves were generated using SoftMax Pro software. IC50 values were determined from four-parameter curve fitting.","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL5725954","document_year":2018,"pchembl_value":"10.22","relation":"=","type":"IC50","units":"nM","value":"0.06"},"molecule":{"canonical_smiles":"COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(C(=O)Nc3cc(C(=O)Nc4cc(C(=O)n5ccc6cc(N)ccc65)n(C)c4)n(C)c3)n1)N=C[C@@H]1Cc3ccccc3N1C2=O","molecule_type":null,"preferred_name":null,"source_molecule_id":"CHEMBL5939267","standard_inchi":"InChI=1S/C46H43N11O7/c1-53-23-29(18-36(53)43(59)49-30-19-37(54(2)24-30)46(62)56-14-13-27-16-28(47)11-12-34(27)56)50-44(60)42-52-40(25-55(42)3)51-41(58)10-7-15-64-39-21-33-32(20-38(39)63-4)45(61)57-31(22-48-33)17-26-8-5-6-9-35(26)57/h5-6,8-9,11-14,16,18-25,31H,7,10,15,17,47H2,1-4H3,(H,49,59)(H,50,60)(H,51,58)/t31-/m0/s1","standard_inchi_key":"GOCWFVHBXZZUFO-HKBQPEDESA-N"},"query_ids":["CH-TARGET-P04626","CH-ACT-CHEMBL1824","CH-MOL-CHEMBL5939267"],"source":"ChEMBL","source_target_id":"CHEMBL1824","target_id":"T-ENSG00000141736","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"P04626"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":"This target contains an intracellular catalytic domain; kinase/catalytic inhibitors must not be treated as extracellular surface-site evidence.","matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"ERBB2","interaction_id":"KCI-CHEMBL-27038405","measurement":{"activity_id":27038405,"assay_chembl_id":"CHEMBL5731752","assay_description":"SKBR3 Cell Viability Assay for Antibody-Polymer-Drug Conjugates: PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega Corp). Cells were plated in black walled 96-well plate and allowed to adhere overnight at 37° C. in a humidified atmosphere of 5% CO2. SKBR3 and were plated at a density of 5,000 cells per well. The next day the medium was replaced with 50 μL fresh medium and 50 μL of 2× stocks of PBD compounds or antibody-PBD conjugate were added to appropriate wells, mixed and incubated for 72 h. CellTiter-Glo® reagent was added to the wells at room temperature and the luminescent signal was measured after 10 min using a SpectraMax M5 plate reader (Molecular Devices). Dose response curves were generated using SoftMax Pro software. IC50 values were determined from four-parameter curve fitting.","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL5725954","document_year":2018,"pchembl_value":"10.05","relation":"=","type":"IC50","units":"nM","value":"0.09"},"molecule":{"canonical_smiles":"C=C1C[C@H]2C=Nc3cc(OCCCC(=O)Nc4cn(C)c(C(=O)Nc5cc(C(=O)Nc6cc(C(=O)n7ncc8cc(N)ccc87)n(C)c6)n(C)c5)n4)c(OC)cc3C(=O)N2C1","molecule_type":null,"preferred_name":null,"source_molecule_id":"CHEMBL6019933","standard_inchi":"InChI=1S/C42H42N12O7/c1-23-11-28-18-44-30-16-35(34(60-5)15-29(30)41(58)53(28)19-23)61-10-6-7-37(55)48-36-22-52(4)38(49-36)40(57)47-26-13-32(50(2)20-26)39(56)46-27-14-33(51(3)21-27)42(59)54-31-9-8-25(43)12-24(31)17-45-54/h8-9,12-18,20-22,28H,1,6-7,10-11,19,43H2,2-5H3,(H,46,56)(H,47,57)(H,48,55)/t28-/m0/s1","standard_inchi_key":"WADINQPENZTYJF-NDEPHWFRSA-N"},"query_ids":["CH-TARGET-P04626","CH-ACT-CHEMBL1824","CH-MOL-CHEMBL6019933"],"source":"ChEMBL","source_target_id":"CHEMBL1824","target_id":"T-ENSG00000141736","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"P04626"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":"This target contains an intracellular catalytic domain; kinase/catalytic inhibitors must not be treated as extracellular surface-site evidence.","matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"EGFR","interaction_id":"KCI-CHEMBL-28394585","measurement":{"activity_id":28394585,"assay_chembl_id":"CHEMBL5736969","assay_description":"Kinase Assay: Buffer formulation: a buffer consisted of 50 mM HEPES (pH 7.5), 0.01% BSA, 5 mM MgCl2, 0.1 mM Orthovanadate. After the buffer was formulated, an enzyme and a substrate were mixed with pre-diluted compounds of varying concentrations, and placed at room temperature for 15 minutes. The reaction was initiated by adding ATP and incubated at room temperature for 60 minutes (wherein negative and positive controls were set up). The 10 μL reaction system consisted of a 2.5 μL compound, a 5 μL mixture of enzyme and substrate, and 2.5 μL ATP. After the reaction was complete, antibodies were added to test, the detection was performed with Evnvision after incubation at room temperature for 60 minutes, and data were collected. Data analysis and simulation were performed using XLfit5 software.","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL5728542","document_year":2021,"pchembl_value":"10.77","relation":"=","type":"IC50","units":"nM","value":"0.017"},"molecule":{"canonical_smiles":"CN1CCC2(CC1)CN(c1ccc3ncnc(Nc4cccc(Cl)c4F)c3c1)C(=O)O2","molecule_type":null,"preferred_name":null,"source_molecule_id":"CHEMBL5746224","standard_inchi":"InChI=1S/C22H21ClFN5O2/c1-28-9-7-22(8-10-28)12-29(21(30)31-22)14-5-6-17-15(11-14)20(26-13-25-17)27-18-4-2-3-16(23)19(18)24/h2-6,11,13H,7-10,12H2,1H3,(H,25,26,27)","standard_inchi_key":"PSYAFMNESHTJGR-UHFFFAOYSA-N"},"query_ids":["CH-TARGET-P00533","CH-ACT-CHEMBL203","CH-MOL-CHEMBL5746224"],"source":"ChEMBL","source_target_id":"CHEMBL203","target_id":"T-ENSG00000146648","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"P00533"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":"This target contains an intracellular catalytic domain; kinase/catalytic inhibitors must not be treated as extracellular surface-site evidence.","matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"EGFR","interaction_id":"KCI-CHEMBL-28394591","measurement":{"activity_id":28394591,"assay_chembl_id":"CHEMBL5736969","assay_description":"Kinase Assay: Buffer formulation: a buffer consisted of 50 mM HEPES (pH 7.5), 0.01% BSA, 5 mM MgCl2, 0.1 mM Orthovanadate. After the buffer was formulated, an enzyme and a substrate were mixed with pre-diluted compounds of varying concentrations, and placed at room temperature for 15 minutes. The reaction was initiated by adding ATP and incubated at room temperature for 60 minutes (wherein negative and positive controls were set up). The 10 μL reaction system consisted of a 2.5 μL compound, a 5 μL mixture of enzyme and substrate, and 2.5 μL ATP. After the reaction was complete, antibodies were added to test, the detection was performed with Evnvision after incubation at room temperature for 60 minutes, and data were collected. Data analysis and simulation were performed using XLfit5 software.","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL5728542","document_year":2021,"pchembl_value":"10.80","relation":"=","type":"IC50","units":"nM","value":"0.016"},"molecule":{"canonical_smiles":"COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1N1CC2(CN(C)C2)OC1=O","molecule_type":null,"preferred_name":null,"source_molecule_id":"CHEMBL5790648","standard_inchi":"InChI=1S/C21H19ClFN5O3/c1-27-8-21(9-27)10-28(20(29)31-21)16-6-12-15(7-17(16)30-2)24-11-25-19(12)26-14-5-3-4-13(22)18(14)23/h3-7,11H,8-10H2,1-2H3,(H,24,25,26)","standard_inchi_key":"DZHGHOYCGHZFFE-UHFFFAOYSA-N"},"query_ids":["CH-TARGET-P00533","CH-ACT-CHEMBL203","CH-MOL-CHEMBL5790648"],"source":"ChEMBL","source_target_id":"CHEMBL203","target_id":"T-ENSG00000146648","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"P00533"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":null,"matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"NT5E","interaction_id":"KCI-CHEMBL-28697858","measurement":{"activity_id":28697858,"assay_chembl_id":"CHEMBL5738091","assay_description":"Enzyme Activity In Vitro Assay: I. Experimental Materials and Equipment1. Malachite green phosphate detection kit (R & D Systems, Cat #, DY996)2. Recombinant human 5′-nucleotidase (CD73) (R & D Systems, Cat #, 5795-EN)3. HEPES buffer (Gibco, Cat #, 15630-080)4. CMP (Sigma, Cat #, C1006)5. DMSO (Fisher Chemical, Cat #, D128-1)6. NaCl 5M (Boston Bioproducts, Cat #, BM-244)7.384-well plate (Fisher, Cat #, 5795-EN)8. TECAN plate reader (TECAN)II. Experimental ProcedureCompounds are first dissolved in DMSO to 10 mM as a stock solution. When determining the IC50 of the compound, prepare 3-fold serial dilutions with a highest concentration of 125 μM for a total of 12 concentration points and ensure each dilution containing equal amount of DMSO. In each well of 384-well plate, 0.34 nM of recombinant human 5′-nucleotidase (CD73) was pre-incubated at 37° C. for 2 hours with the compounds tested in assay buffer containing 20 mM HEPES buffer (pH 7.4), 137 mM NaCl, 0.001% Tween 20. The final reaction volume of the reaction in each well was 12 μL. The highest concentration of compound was 125 μM and the DMSO concentration was 1.25%. After pre-incubation, 3 μL of CMP dissolved in assay buffer was added to each reaction. The final CMP concentration was 45 μM. The reaction was incubated at 37° C. for 15 minutes. Then 3 μL of Malachite Green Reagent A was added to each reaction. Spin the plate briefly in centrifuge for 30 seconds. After incubation for additional 10 minutes at room temperature, 3 μL of malachite green Reagent B was added to each reaction. Spin the plate briefly in centrifuge for 30 seconds. After 20 minutes of incubation at room temperature, the signal was read on a TECAN reader at OD620.","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL5729111","document_year":2022,"pchembl_value":"10.89","relation":"=","type":"IC50","units":"nM","value":"0.013"},"molecule":{"canonical_smiles":"O=P(O)(O)COC[C@H]1O[C@@H](n2ncc3c(N4CC5(CCc6ccccc65)C4)nc(Cl)nc32)[C@H](O)[C@@H]1O","molecule_type":null,"preferred_name":null,"source_molecule_id":"CHEMBL5431118","standard_inchi":"InChI=1S/C22H25ClN5O7P/c23-21-25-18(27-9-22(10-27)6-5-12-3-1-2-4-14(12)22)13-7-24-28(19(13)26-21)20-17(30)16(29)15(35-20)8-34-11-36(31,32)33/h1-4,7,15-17,20,29-30H,5-6,8-11H2,(H2,31,32,33)/t15-,16-,17-,20-/m1/s1","standard_inchi_key":"NAHILNAHEKBGES-WOCWXWTJSA-N"},"query_ids":["CH-TARGET-P21589","CH-ACT-CHEMBL5957","CH-MOL-CHEMBL5431118"],"source":"ChEMBL","source_target_id":"CHEMBL5957","target_id":"T-ENSG00000135318","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"P21589"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":"This target contains an intracellular catalytic domain; kinase/catalytic inhibitors must not be treated as extracellular surface-site evidence.","matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"ERBB2","interaction_id":"KCI-CHEMBL-29092486","measurement":{"activity_id":29092486,"assay_chembl_id":"CHEMBL6083475","assay_description":"Inhibition of HER2 (unknown origin)","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL6083185","document_year":2024,"pchembl_value":"10.40","relation":"=","type":"IC50","units":"nM","value":"0.04"},"molecule":{"canonical_smiles":"COc1cc2c(Nc3ccc(Oc4ccn5ncnc5c4)c(C)c3)ncnc2cc1OCCCN1CCN(CCCCCCCNc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","molecule_type":null,"preferred_name":null,"source_molecule_id":"CHEMBL6132997","standard_inchi":"InChI=1S/C49H55N11O7/c1-32-25-34(10-13-41(32)67-35-15-19-59-44(27-35)52-31-54-59)55-46-38-28-42(65-2)43(29-39(38)51-30-53-46)66-24-8-18-58-22-20-57(21-23-58)17-7-5-3-4-6-16-50-33-9-11-36-37(26-33)49(64)60(48(36)63)40-12-14-45(61)56-47(40)62/h9-11,13,15,19,25-31,40,50H,3-8,12,14,16-18,20-24H2,1-2H3,(H,51,53,55)(H,56,61,62)","standard_inchi_key":"IQCKLHMMRZVWLF-UHFFFAOYSA-N"},"query_ids":["CH-TARGET-P04626","CH-ACT-CHEMBL1824","CH-MOL-CHEMBL6132997"],"source":"ChEMBL","source_target_id":"CHEMBL1824","target_id":"T-ENSG00000141736","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"P04626"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":null,"matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"FAP","interaction_id":"KCI-CHEMBL-29108075","measurement":{"activity_id":29108075,"assay_chembl_id":"CHEMBL6087936","assay_description":"Inhibition of recombinant human FAP extracted from S2 cells immobilized on plate surface using specific antibody assessed as inhibition constant measured after 2 hrs incubation by DNA-linked Inhibitor Antibody Assay (DIANA)","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL6087393","document_year":2024,"pchembl_value":"9.96","relation":"=","type":"Ki","units":"nM","value":"0.11"},"molecule":{"canonical_smiles":"COc1ccc(CNC(=O)C(=O)[C@@H]2CCCN2C(=O)CNC(=O)c2ccnc3ccc(OCCNC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])cc23)cc1OC","molecule_type":null,"preferred_name":null,"source_molecule_id":"CHEMBL6147832","standard_inchi":"InChI=1S/C48H68N8O16/c1-62-42-8-5-36(32-43(42)63-2)34-52-48(61)46(59)41-4-3-14-56(41)45(58)35-53-47(60)38-9-11-50-40-7-6-37(33-39(38)40)72-17-12-51-44(57)10-15-64-18-20-66-22-24-68-26-28-70-30-31-71-29-27-69-25-23-67-21-19-65-16-13-54-55-49/h5-9,11,32-33,41H,3-4,10,12-31,34-35H2,1-2H3,(H,51,57)(H,52,61)(H,53,60)/t41-/m0/s1","standard_inchi_key":"JZWUOXYHHOXDSG-RWYGWLOXSA-N"},"query_ids":["CH-TARGET-Q12884","CH-ACT-CHEMBL4683","CH-MOL-CHEMBL6147832"],"source":"ChEMBL","source_target_id":"CHEMBL4683","target_id":"T-ENSG00000078098","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"Q12884"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":"This target contains an intracellular catalytic domain; kinase/catalytic inhibitors must not be treated as extracellular surface-site evidence.","matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"EGFR","interaction_id":"KCI-CHEMBL-29113767","measurement":{"activity_id":29113767,"assay_chembl_id":"CHEMBL6089387","assay_description":"Inhibition of wild type EGFR (unknown origin)","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL6087440","document_year":2025,"pchembl_value":"11.00","relation":"=","type":"IC50","units":"nM","value":"0.01"},"molecule":{"canonical_smiles":"COc1cc(N2CCC(N(C)C)CC2)ccc1Nc1ncc(C(=O)Oc2ccccc2)c(-c2c[nH]c3ccccc23)n1","molecule_type":null,"preferred_name":null,"source_molecule_id":"CHEMBL5270693","standard_inchi":"InChI=1S/C33H34N6O3/c1-38(2)22-15-17-39(18-16-22)23-13-14-29(30(19-23)41-3)36-33-35-21-27(32(40)42-24-9-5-4-6-10-24)31(37-33)26-20-34-28-12-8-7-11-25(26)28/h4-14,19-22,34H,15-18H2,1-3H3,(H,35,36,37)","standard_inchi_key":"PTQTXSUYGYJJKM-UHFFFAOYSA-N"},"query_ids":["CH-TARGET-P00533","CH-ACT-CHEMBL203","CH-MOL-CHEMBL5270693"],"source":"ChEMBL","source_target_id":"CHEMBL203","target_id":"T-ENSG00000146648","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"P00533"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":null,"matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"NT5E","interaction_id":"KCI-CHEMBL-29220906","measurement":{"activity_id":29220906,"assay_chembl_id":"CHEMBL6125220","assay_description":"Inhibition of recombinant human CD73 preincubated for 15 mins followed by AMP addition measured after 10 mins by LC/MS analysis","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL6121027","document_year":2025,"pchembl_value":"10.70","relation":"=","type":"IC50","units":"nM","value":"0.02"},"molecule":{"canonical_smiles":"Cn1nc(O[C@H](c2ccnc(OCC(F)(F)F)c2)C(F)F)c2cc(-c3n[nH]c(=O)[nH]c3=O)nnc21","molecule_type":null,"preferred_name":null,"source_molecule_id":"CHEMBL6162112","standard_inchi":"InChI=1S/C18H13F5N8O4/c1-31-14-8(5-9(26-28-14)11-15(32)25-17(33)29-27-11)16(30-31)35-12(13(19)20)7-2-3-24-10(4-7)34-6-18(21,22)23/h2-5,12-13H,6H2,1H3,(H2,25,29,32,33)/t12-/m1/s1","standard_inchi_key":"BMQDPHODVMANDJ-GFCCVEGCSA-N"},"query_ids":["CH-TARGET-P21589","CH-ACT-CHEMBL5957","CH-MOL-CHEMBL6162112"],"source":"ChEMBL","source_target_id":"CHEMBL5957","target_id":"T-ENSG00000135318","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"P21589"},{"claim_ceiling":"measured ChEMBL target activity; not proof of binding at a deposited extracellular site, surface accessibility, therapeutic action, selectivity, or efficacy","deposited_extracellular_site_relevance":{"intracellular_domain_interpretation_guard":null,"matched_actionable_site_ids":[],"reason":"The measured database activity is assigned to the protein target but does not localize binding to a deposited extracellular pocket or interface.","state":"target-level-not-site-localized"},"evidence_class":"measured-binding-database-record","gene_symbol":"NT5E","interaction_id":"KCI-CHEMBL-29220907","measurement":{"activity_id":29220907,"assay_chembl_id":"CHEMBL6125220","assay_description":"Inhibition of recombinant human CD73 preincubated for 15 mins followed by AMP addition measured after 10 mins by LC/MS analysis","assay_type":"B","assay_variant_accession":null,"assay_variant_mutation":null,"document_chembl_id":"CHEMBL6121027","document_year":2025,"pchembl_value":"10.70","relation":"=","type":"IC50","units":"nM","value":"0.02"},"molecule":{"canonical_smiles":"Cn1nc(O[C@H](c2ccnc(OCC(F)F)c2)C(F)F)c2cc(-c3n[nH]c(=O)[nH]c3=O)nnc21","molecule_type":null,"preferred_name":null,"source_molecule_id":"CHEMBL6152291","standard_inchi":"InChI=1S/C18H14F4N8O4/c1-30-15-8(5-9(25-27-15)12-16(31)24-18(32)28-26-12)17(29-30)34-13(14(21)22)7-2-3-23-11(4-7)33-6-10(19)20/h2-5,10,13-14H,6H2,1H3,(H2,24,28,31,32)/t13-/m1/s1","standard_inchi_key":"BXKYIBVFYXIQHU-CYBMUJFWSA-N"},"query_ids":["CH-TARGET-P21589","CH-ACT-CHEMBL5957","CH-MOL-CHEMBL6152291"],"source":"ChEMBL","source_target_id":"CHEMBL5957","target_id":"T-ENSG00000135318","target_resolution":"exact-human-single-protein-accession","uniprot_accession":"P21589"}],"schema_version":"codex-surface-known-compound-interaction-collection/v0.1","selection_contract":{"bindingdb_cutoff_nM":10,"bindingdb_helper_max_items":10,"bindingdb_limit_note":"The REST endpoint is threshold-bounded rather than page-bounded. Full threshold-matched raw payloads are retained externally; only the five lowest numeric affinities per query enter this compact collection.","bindingdb_pdb_identity_percent":100,"bindingdb_unique_molecules_selected_per_query":5,"chembl_activity_page_limit":20,"chembl_order":"descending pChEMBL, then ascending standard value, then activity ID","chembl_target_resolution":"human SINGLE PROTEIN with exact UniProt component accession","chembl_unique_molecules_selected_per_target":5,"scope":"exactly the ten Structure-A targets"},"source_inputs":{"actionable_sites":{"bytes":272569,"name":"actionable-sites.json","sha256":"07f5d2921fdf8345e0540003b0cb9ad50d8d42c349c95b2ae1dc26b2763d2897"},"structures":{"bytes":228650,"name":"structures.json","sha256":"42015660cf5e51fb59cf5159077b29a3daae6012fca9fde8307e9487815ab72d"},"targets":{"bytes":2563163,"name":"targets.json","sha256":"c6e20ca44b161b182f2c298dde20afcfb384e382a71d0926f21461aec3fd29a4"}},"source_routes":{"bindingdb":{"base_url":"https://bindingdb.org","rest_script_sha256":"ebd7c860aee32c21897192bbfab676345dc3f595781fe7a36fc0e1610e1d126b","transport":"Rosalind BindingDB skill scripts/rest_request.py"},"chembl":{"base_url":"https://www.ebi.ac.uk/chembl/api/data","rest_script_sha256":"ebd7c860aee32c21897192bbfab676345dc3f595781fe7a36fc0e1610e1d126b","transport":"Rosalind ChEMBL skill scripts/rest_request.py"}},"target_coverage":[{"chembl_target_id":"CHEMBL3714583","claim_ceiling":"bounded evidence coverage; zero selected records is not evidence of no binding","gene_symbol":"CD47","interaction_ids":["KCI-CHEMBL-16668997","KCI-CHEMBL-16668998","KCI-CHEMBL-16668999","KCI-CHEMBL-16669000","KCI-CHEMBL-19306596"],"pdb_accessions_queried":["2JJS"],"query_ids":["BDB-PDB-2JJS","BDB-UNI-Q08722","CH-ACT-CHEMBL3714583","CH-MOL-CHEMBL3891508","CH-MOL-CHEMBL3946082","CH-MOL-CHEMBL3971661","CH-MOL-CHEMBL3974452","CH-MOL-CHEMBL4522427","CH-TARGET-Q08722"],"state":"represented","target_id":"T-ENSG00000196776","uniprot_accession":"Q08722"},{"chembl_target_id":"CHEMBL3712881","claim_ceiling":"bounded evidence coverage; zero selected records is not evidence of no binding","gene_symbol":"CEACAM5","interaction_ids":[],"pdb_accessions_queried":["8BW0"],"query_ids":["BDB-PDB-8BW0","BDB-UNI-P06731","CH-ACT-CHEMBL3712881","CH-TARGET-P06731"],"state":"queried-no-selected-records","target_id":"T-ENSG00000105388","uniprot_accession":"P06731"},{"chembl_target_id":"CHEMBL203","claim_ceiling":"bounded evidence coverage; zero selected records is not evidence of no binding","gene_symbol":"EGFR","interaction_ids":["KCI-BINDINGDB-45e84700f5818806","KCI-BINDINGDB-6208f22d1f1d6c16","KCI-BINDINGDB-8e6d653dad238487","KCI-BINDINGDB-9dd515e75e406f98","KCI-BINDINGDB-d0212c8a52918ef8","KCI-CHEMBL-1043415","KCI-CHEMBL-25098086","KCI-CHEMBL-28394585","KCI-CHEMBL-28394591","KCI-CHEMBL-29113767"],"pdb_accessions_queried":["1YY9"],"query_ids":["BDB-PDB-1YY9","BDB-UNI-P00533","CH-ACT-CHEMBL203","CH-MOL-CHEMBL176582","CH-MOL-CHEMBL4650319","CH-MOL-CHEMBL5270693","CH-MOL-CHEMBL5746224","CH-MOL-CHEMBL5790648","CH-TARGET-P00533"],"state":"represented","target_id":"T-ENSG00000146648","uniprot_accession":"P00533"},{"chembl_target_id":"CHEMBL3580493","claim_ceiling":"bounded evidence coverage; zero selected records is not evidence of no binding","gene_symbol":"EPCAM","interaction_ids":["KCI-BINDINGDB-5116757b4315b4d0","KCI-CHEMBL-26218781"],"pdb_accessions_queried":["6I07"],"query_ids":["BDB-PDB-6I07","BDB-UNI-P16422","CH-ACT-CHEMBL3580493","CH-MOL-CHEMBL5653589","CH-TARGET-P16422"],"state":"represented","target_id":"T-ENSG00000119888","uniprot_accession":"P16422"},{"chembl_target_id":"CHEMBL1824","claim_ceiling":"bounded evidence coverage; zero selected records is not evidence of no binding","gene_symbol":"ERBB2","interaction_ids":["KCI-BINDINGDB-105a0ec5c5afc361","KCI-BINDINGDB-1fa8c2e7dbcb2120","KCI-BINDINGDB-68892344b2bdbb35","KCI-BINDINGDB-76ea6126757b4230","KCI-BINDINGDB-ad246683fd17786d","KCI-CHEMBL-24962907","KCI-CHEMBL-24962908","KCI-CHEMBL-27038390","KCI-CHEMBL-27038405","KCI-CHEMBL-29092486"],"pdb_accessions_queried":["1N8Z"],"query_ids":["BDB-PDB-1N8Z","BDB-UNI-P04626","CH-ACT-CHEMBL1824","CH-MOL-CHEMBL5221067","CH-MOL-CHEMBL5939267","CH-MOL-CHEMBL6019933","CH-MOL-CHEMBL6132997","CH-MOL-CHEMBL941","CH-TARGET-P04626"],"state":"represented","target_id":"T-ENSG00000141736","uniprot_accession":"P04626"},{"chembl_target_id":"CHEMBL4683","claim_ceiling":"bounded evidence coverage; zero selected records is not evidence of no binding","gene_symbol":"FAP","interaction_ids":["KCI-BINDINGDB-0ac9eba24bfde384","KCI-BINDINGDB-8a02e58de3e24193","KCI-BINDINGDB-de51191c2a73a9a3","KCI-BINDINGDB-e89a96026ae4d4d1","KCI-BINDINGDB-fad46cd8f75e9711","KCI-CHEMBL-23308620","KCI-CHEMBL-23308621","KCI-CHEMBL-23308626","KCI-CHEMBL-23308637","KCI-CHEMBL-29108075"],"pdb_accessions_queried":["6Y0F","9DVR"],"query_ids":["BDB-PDB-6Y0F","BDB-PDB-9DVR","BDB-UNI-Q12884","CH-ACT-CHEMBL4683","CH-MOL-CHEMBL4853661","CH-MOL-CHEMBL4864809","CH-MOL-CHEMBL4877950","CH-MOL-CHEMBL4878759","CH-MOL-CHEMBL6147832","CH-TARGET-Q12884"],"state":"represented","target_id":"T-ENSG00000078098","uniprot_accession":"Q12884"},{"chembl_target_id":"CHEMBL1795197","claim_ceiling":"bounded evidence coverage; zero selected records is not evidence of no binding","gene_symbol":"GUCY2C","interaction_ids":[],"pdb_accessions_queried":["8GHP"],"query_ids":["BDB-PDB-8GHP","BDB-UNI-P25092","CH-ACT-CHEMBL1795197","CH-TARGET-P25092"],"state":"queried-no-selected-records","target_id":"T-ENSG00000070019","uniprot_accession":"P25092"},{"chembl_target_id":"CHEMBL3717","claim_ceiling":"bounded evidence coverage; zero selected records is not evidence of no binding","gene_symbol":"MET","interaction_ids":["KCI-BINDINGDB-07b5180568b7a80a","KCI-BINDINGDB-086ad40138f8ffc9","KCI-BINDINGDB-7e6ba957e80bed5b","KCI-BINDINGDB-e5a7cd86571d5244","KCI-BINDINGDB-e5c5966f67a1df06","KCI-CHEMBL-15614613","KCI-CHEMBL-17688600","KCI-CHEMBL-24687320","KCI-CHEMBL-24687321","KCI-CHEMBL-25106956"],"pdb_accessions_queried":["4K3J"],"query_ids":["BDB-PDB-4K3J","BDB-UNI-P08581","CH-ACT-CHEMBL3717","CH-MOL-CHEMBL3582305","CH-MOL-CHEMBL3668200","CH-MOL-CHEMBL3797911","CH-MOL-CHEMBL5174958","CH-MOL-CHEMBL5184459","CH-TARGET-P08581"],"state":"represented","target_id":"T-ENSG00000105976","uniprot_accession":"P08581"},{"chembl_target_id":"CHEMBL5957","claim_ceiling":"bounded evidence coverage; zero selected records is not evidence of no binding","gene_symbol":"NT5E","interaction_ids":["KCI-BINDINGDB-28c1c93d467d5e41","KCI-BINDINGDB-29aeb14112f4c59d","KCI-BINDINGDB-4ca4e279a02ca5b9","KCI-BINDINGDB-737fe486bdd27f84","KCI-BINDINGDB-fb5a19e615ed96ca","KCI-CHEMBL-22396873","KCI-CHEMBL-22396878","KCI-CHEMBL-28697858","KCI-CHEMBL-29220906","KCI-CHEMBL-29220907"],"pdb_accessions_queried":["7BBJ","9R0G"],"query_ids":["BDB-PDB-7BBJ","BDB-PDB-9R0G","BDB-UNI-P21589","CH-ACT-CHEMBL5957","CH-MOL-CHEMBL4471306","CH-MOL-CHEMBL4761506","CH-MOL-CHEMBL5431118","CH-MOL-CHEMBL6152291","CH-MOL-CHEMBL6162112","CH-TARGET-P21589"],"state":"represented","target_id":"T-ENSG00000135318","uniprot_accession":"P21589"},{"chembl_target_id":"CHEMBL3856163","claim_ceiling":"bounded evidence coverage; zero selected records is not evidence of no binding","gene_symbol":"TACSTD2","interaction_ids":[],"pdb_accessions_queried":["9PI9"],"query_ids":["BDB-PDB-9PI9","BDB-UNI-P09758","CH-ACT-CHEMBL3856163","CH-TARGET-P09758"],"state":"queried-no-selected-records","target_id":"T-ENSG00000184292","uniprot_accession":"P09758"}],"unresolved":[{"error":"Request failed for bindingdb-skill: HTTPError","gene_symbol":"GUCY2C","query_id":"BDB-PDB-8GHP","source":"BindingDB","state":"query-failed","target_id":"T-ENSG00000070019"},{"error":"Request failed for bindingdb-skill: HTTPError","gene_symbol":"CEACAM5","query_id":"BDB-PDB-8BW0","source":"BindingDB","state":"query-failed","target_id":"T-ENSG00000105388"},{"error":"Request failed for bindingdb-skill: HTTPError","gene_symbol":"EPCAM","query_id":"BDB-PDB-6I07","source":"BindingDB","state":"query-failed","target_id":"T-ENSG00000119888"},{"error":"Request failed for bindingdb-skill: HTTPError","gene_symbol":"NT5E","query_id":"BDB-PDB-7BBJ","source":"BindingDB","state":"query-failed","target_id":"T-ENSG00000135318"},{"error":"Request failed for bindingdb-skill: HTTPError","gene_symbol":"NT5E","query_id":"BDB-PDB-9R0G","source":"BindingDB","state":"query-failed","target_id":"T-ENSG00000135318"},{"error":"Request failed for bindingdb-skill: HTTPError","gene_symbol":"EGFR","query_id":"BDB-PDB-1YY9","source":"BindingDB","state":"query-failed","target_id":"T-ENSG00000146648"},{"error":"Request failed for bindingdb-skill: HTTPError","gene_symbol":"TACSTD2","query_id":"BDB-PDB-9PI9","source":"BindingDB","state":"query-failed","target_id":"T-ENSG00000184292"},{"error":"Request failed for bindingdb-skill: HTTPError","gene_symbol":"CD47","query_id":"BDB-PDB-2JJS","source":"BindingDB","state":"query-failed","target_id":"T-ENSG00000196776"}]}