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Recruited to desmosomes at the initial assembly phase and also accumulates progressively at mature desmosome cell-cell junctions (PubMed:25208567, PubMed:29999492). Localizes to cell-cell contacts as keratinocyte differentiation progresses (By similarity). {ECO:0000250|UniProtKB:P09803, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:29999492}.; SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:34742300}. 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/evidence=\"ECO:0000269|PubMed:10373415, ECO:0000269|PubMed:11341784\"","subcellular_location":"SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:11118479, ECO:0000269|PubMed:12832415, ECO:0000269|PubMed:12939402, ECO:0000269|PubMed:15471854, ECO:0000269|PubMed:15972891, ECO:0000269|PubMed:16507569, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:17545600}; Single-pass type I membrane protein {ECO:0000269|PubMed:11118479, ECO:0000269|PubMed:12832415, ECO:0000269|PubMed:12939402, ECO:0000269|PubMed:15471854, ECO:0000269|PubMed:15972891, ECO:0000269|PubMed:16507569, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:17545600}. Note=Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis, internalized and recycled to the cell membrane. Located to microvilli and to the tips of long filopodial protusions.; SUBCELLULAR LOCATION: [Isoform 5]: Secreted.; SUBCELLULAR LOCATION: [Isoform Y]: Secreted.; SUBCELLULAR LOCATION: [Isoform 9]: Secreted.; SUBCELLULAR LOCATION: [Mucin-1 subunit beta]: Cell membrane. Cytoplasm. Nucleus. Note=On EGF and PDGFRB stimulation, transported to the nucleus through interaction with CTNNB1, a process which is stimulated by phosphorylation. On HRG stimulation, colocalizes with JUP/gamma-catenin at the nucleus.","topological_domain":"TOPO_DOM 24..1158; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 1182..1255; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 1159..1181; /note=\"Helical\"; /evidence=\"ECO:0000255\""},"signal_peptides":[{"description":null,"end":23,"evidence":"ECO:0000269|PubMed:10373415, ECO:0000269|PubMed:11341784","source_location":"SIGNAL 1..23; /evidence=\"ECO:0000269|PubMed:10373415, ECO:0000269|PubMed:11341784\"","start":1}],"state":"available","topological_domains":[{"description":"Extracellular","end":1158,"evidence":"ECO:0000255","source_location":"TOPO_DOM 24..1158; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":24},{"description":"Cytoplasmic","end":1255,"evidence":"ECO:0000255","source_location":"TOPO_DOM 1182..1255; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":1182}],"transmembrane_segments":[{"description":"Helical","end":1181,"evidence":"ECO:0000255","source_location":"TRANSMEM 1159..1181; 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Endoplasmic reticulum membrane {ECO:0000269|PubMed:27153536}; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Endosome {ECO:0000269|PubMed:17182860, ECO:0000269|PubMed:27153536}. Endosome membrane. Nucleus {ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:20551055, ECO:0000269|PubMed:20674546}. Note=In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER (PubMed:17909029, PubMed:20674546). Endocytosed upon activation by ligand (PubMed:17182860, PubMed:17909029, PubMed:27153536, PubMed:2790960). 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Cell membrane {ECO:0000269|PubMed:23704991}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:20375010}. 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Multi-pass membrane protein {ECO:0000255}. Melanosome {ECO:0000269|PubMed:17081065}. Photoreceptor inner segment {ECO:0000250|UniProtKB:P17809}. Note=Localizes primarily at the cell surface (PubMed:18245775, PubMed:19449892, PubMed:23219802, PubMed:24847886, PubMed:25982116). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). {ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:18245775, ECO:0000269|PubMed:19449892, ECO:0000269|PubMed:23219802, ECO:0000269|PubMed:24847886, ECO:0000269|PubMed:25982116}.","topological_domain":"TOPO_DOM 1..11; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:24847886\"; TOPO_DOM 34..66; /note=\"Extracellular\"; /evidence=\"ECO:0000269|PubMed:24847886\"; TOPO_DOM 88..90; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:24847886\"; TOPO_DOM 113..120; /note=\"Extracellular\"; /evidence=\"ECO:0000269|PubMed:24847886\"; TOPO_DOM 145..155; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:24847886\"; TOPO_DOM 177..185; /note=\"Extracellular\"; /evidence=\"ECO:0000269|PubMed:24847886\"; TOPO_DOM 207..271; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:24847886\"; TOPO_DOM 294..306; /note=\"Extracellular\"; /evidence=\"ECO:0000269|PubMed:24847886\"; TOPO_DOM 329..334; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:24847886\"; TOPO_DOM 356..365; /note=\"Extracellular\"; /evidence=\"ECO:0000269|PubMed:24847886\"; TOPO_DOM 389..401; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:24847886\"; TOPO_DOM 423..429; /note=\"Extracellular\"; /evidence=\"ECO:0000269|PubMed:24847886\"; TOPO_DOM 451..492; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:24847886\"","transmembrane":"TRANSMEM 12..33; /note=\"Helical; Name=1\"; TRANSMEM 67..87; /note=\"Helical; Name=2\"; TRANSMEM 91..112; /note=\"Helical; Name=3\"; TRANSMEM 121..144; /note=\"Helical; Name=4\"; TRANSMEM 156..176; /note=\"Helical; Name=5\"; TRANSMEM 186..206; /note=\"Helical; Name=6\"; TRANSMEM 272..293; /note=\"Helical; Name=7\"; TRANSMEM 307..328; /note=\"Helical; Name=8\"; TRANSMEM 335..355; /note=\"Helical; Name=9\"; TRANSMEM 366..388; /note=\"Helical; Name=10\"; TRANSMEM 402..422; /note=\"Helical; Name=11\"; TRANSMEM 430..450; /note=\"Helical; Name=12\""},"signal_peptides":[],"state":"available","topological_domains":[{"description":"Cytoplasmic","end":11,"evidence":"ECO:0000269|PubMed:24847886","source_location":"TOPO_DOM 1..11; 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/note=\"Extracellular\"; /evidence=\"ECO:0000269|PubMed:24847886\"","start":423},{"description":"Cytoplasmic","end":492,"evidence":"ECO:0000269|PubMed:24847886","source_location":"TOPO_DOM 451..492; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:24847886\"","start":451}],"transmembrane_segments":[{"description":"Helical; Name=1","end":33,"evidence":null,"source_location":"TRANSMEM 12..33; /note=\"Helical; Name=1\"","start":12},{"description":"Helical; Name=2","end":87,"evidence":null,"source_location":"TRANSMEM 67..87; /note=\"Helical; Name=2\"","start":67},{"description":"Helical; Name=3","end":112,"evidence":null,"source_location":"TRANSMEM 91..112; /note=\"Helical; Name=3\"","start":91},{"description":"Helical; Name=4","end":144,"evidence":null,"source_location":"TRANSMEM 121..144; /note=\"Helical; Name=4\"","start":121},{"description":"Helical; Name=5","end":176,"evidence":null,"source_location":"TRANSMEM 156..176; /note=\"Helical; Name=5\"","start":156},{"description":"Helical; 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/evidence=\"ECO:0000269|PubMed:8119947\"","subcellular_location":"SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.","topological_domain":"TOPO_DOM 19..1126; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 1148..1179; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 1127..1147; /note=\"Helical\"; /evidence=\"ECO:0000255\""},"signal_peptides":[{"description":null,"end":18,"evidence":"ECO:0000269|PubMed:8119947","source_location":"SIGNAL 1..18; /evidence=\"ECO:0000269|PubMed:8119947\"","start":1}],"state":"available","topological_domains":[{"description":"Extracellular","end":1126,"evidence":"ECO:0000255","source_location":"TOPO_DOM 19..1126; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":19},{"description":"Cytoplasmic","end":1179,"evidence":"ECO:0000255","source_location":"TOPO_DOM 1148..1179; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":1148}],"transmembrane_segments":[{"description":"Helical","end":1147,"evidence":"ECO:0000255","source_location":"TRANSMEM 1127..1147; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":1127}]},"uniprot_accession":"P38570"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000105976","evidence_rank":23,"extracellular_segments":{"records":[{"basis":"reviewed-uniprot-topological-domain","end":932,"evidence_class":"source-annotated-topology","length":908,"sequence":"ECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSALGAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLDAQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRSAMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGWCHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEFAVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFT","sequence_sha256":"6069a4885da6c3cf4cf37f6bfb3f22e9fc5ce1c79f4477e63f1cba2a8a75c2d1","start":25}],"state":"source-annotated"},"gene_symbol":"MET","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSALGAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLDAQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRSAMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGWCHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEFAVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVDTRPASFWETS","length":1390,"sha256":"cc24e8701a5717fd1fa418174adb3b6cbaeae8a76f78b33a995f44c5bb394056","state":"available"},"source_refs":[{"artifact":{"bytes":11795,"format":"json","sha256":"01bdedbc1ee4289b1b17ddb453a556699e897c7a0d75eb5a83c7fd639154e022","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/P08581"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"P08581","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"structure-a","target_id":"T-ENSG00000105976","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":1390},"entry_name":"MET_HUMAN","gene_names":"MET","lipidation_sites":[],"protein_names":"Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)","raw_fields":{"lipidation":"","signal_peptide":"SIGNAL 1..24; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted.","topological_domain":"TOPO_DOM 25..932; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 956..1390; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 933..955; /note=\"Helical\"; /evidence=\"ECO:0000255\""},"signal_peptides":[{"description":null,"end":24,"evidence":"ECO:0000255","source_location":"SIGNAL 1..24; /evidence=\"ECO:0000255\"","start":1}],"state":"available","topological_domains":[{"description":"Extracellular","end":932,"evidence":"ECO:0000255","source_location":"TOPO_DOM 25..932; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":25},{"description":"Cytoplasmic","end":1390,"evidence":"ECO:0000255","source_location":"TOPO_DOM 956..1390; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":956}],"transmembrane_segments":[{"description":"Helical","end":955,"evidence":"ECO:0000255","source_location":"TRANSMEM 933..955; 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/evidence=\"ECO:0000269|PubMed:15340161\"","subcellular_location":"SUBCELLULAR LOCATION: Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:17081065}.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:25957687}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453}. Photoreceptor inner segment {ECO:0000250|UniProtKB:P18572}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:P18572}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:11992541, ECO:0000269|PubMed:15688292, ECO:0000269|PubMed:15946952, ECO:0000269|PubMed:17127621, ECO:0000269|PubMed:21536654, ECO:0000269|PubMed:25825981, ECO:0000269|PubMed:26195724, ECO:0000269|PubMed:28409866, ECO:0000269|PubMed:29739904}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453}. Endosome {ECO:0000269|PubMed:29739904}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:15688292}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453}. Basolateral cell membrane {ECO:0000269|PubMed:17267690}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453}.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane {ECO:0000269|PubMed:21536654}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453}.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane {ECO:0000269|PubMed:21536654}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453}.","topological_domain":"TOPO_DOM 138..325; /note=\"Extracellular\"; /evidence=\"ECO:0000269|PubMed:34625749, ECO:0000269|PubMed:38364890, ECO:0007744|PDB:7DCE, ECO:0007744|PDB:8XEJ\"; TOPO_DOM 345..385; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:34625749, ECO:0000269|PubMed:38364890, ECO:0007744|PDB:7DCE, ECO:0007744|PDB:8XEJ\"","transmembrane":"TRANSMEM 326..344; /note=\"Helical\"; /evidence=\"ECO:0000269|PubMed:34625749, ECO:0000269|PubMed:38364890, ECO:0007744|PDB:7DCE, ECO:0007744|PDB:8XEJ\""},"signal_peptides":[{"description":null,"end":21,"evidence":"ECO:0000269|PubMed:15340161","source_location":"SIGNAL 1..21; /evidence=\"ECO:0000269|PubMed:15340161\"","start":1}],"state":"available","topological_domains":[{"description":"Extracellular","end":325,"evidence":"ECO:0000269|PubMed:34625749, ECO:0000269|PubMed:38364890, ECO:0007744|PDB:7DCE, ECO:0007744|PDB:8XEJ","source_location":"TOPO_DOM 138..325; /note=\"Extracellular\"; /evidence=\"ECO:0000269|PubMed:34625749, ECO:0000269|PubMed:38364890, ECO:0007744|PDB:7DCE, ECO:0007744|PDB:8XEJ\"","start":138},{"description":"Cytoplasmic","end":385,"evidence":"ECO:0000269|PubMed:34625749, ECO:0000269|PubMed:38364890, ECO:0007744|PDB:7DCE, ECO:0007744|PDB:8XEJ","source_location":"TOPO_DOM 345..385; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:34625749, ECO:0000269|PubMed:38364890, ECO:0007744|PDB:7DCE, ECO:0007744|PDB:8XEJ\"","start":345}],"transmembrane_segments":[{"description":"Helical","end":344,"evidence":"ECO:0000269|PubMed:34625749, ECO:0000269|PubMed:38364890, ECO:0007744|PDB:7DCE, ECO:0007744|PDB:8XEJ","source_location":"TRANSMEM 326..344; /note=\"Helical\"; /evidence=\"ECO:0000269|PubMed:34625749, ECO:0000269|PubMed:38364890, ECO:0007744|PDB:7DCE, ECO:0007744|PDB:8XEJ\"","start":326}]},"uniprot_accession":"P35613"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000019582","evidence_rank":28,"extracellular_segments":{"records":[{"basis":"reviewed-uniprot-topological-domain","end":296,"evidence_class":"source-annotated-topology","length":224,"sequence":"QQQGRLDKLTVTSQNLQLENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQKPTDAPPKVLTKCQEEVSHIPAVHPGSFRPKCDENGNYLPLQCYGSIGYCWCVFPNGTEVPNTRSRGHHNCSESLELEDPSSGLGVTKQDLGPVPM","sequence_sha256":"4c6a65f31114216087588bc2f5a42600f9a25cb2046733fe44f984338750b607","start":73}],"state":"source-annotated"},"gene_symbol":"CD74","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQKPTDAPPKVLTKCQEEVSHIPAVHPGSFRPKCDENGNYLPLQCYGSIGYCWCVFPNGTEVPNTRSRGHHNCSESLELEDPSSGLGVTKQDLGPVPM","length":296,"sha256":"f6909ab67f84bc41d8ef8976b6e5634ebcb9031613d297ac41e582c377b48728","state":"available"},"source_refs":[{"artifact":{"bytes":10084,"format":"json","sha256":"b1919afcf582e3b8305172693c73112cf13c60cd65f10a4c46f32fba84141e9d","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/P04233"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"P04233","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"retained-unmodeled","target_id":"T-ENSG00000019582","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":296},"entry_name":"HG2A_HUMAN","gene_names":"CD74 DHLAG","lipidation_sites":[],"protein_names":"HLA class II histocompatibility antigen gamma chain (HLA-DR antigens-associated invariant chain) (Ia antigen-associated invariant chain) (Ii) (CD antigen CD74) [Cleaved into: Class-II-associated invariant chain peptide (CLIP)]","raw_fields":{"lipidation":"","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. 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/evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane; Single-pass type I membrane protein.","topological_domain":"TOPO_DOM 21..417; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 439..913; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 418..438; /note=\"Helical\"; /evidence=\"ECO:0000255\""},"signal_peptides":[{"description":null,"end":18,"evidence":"ECO:0000255","source_location":"SIGNAL 1..18; /evidence=\"ECO:0000255\"","start":1}],"state":"available","topological_domains":[{"description":"Extracellular","end":417,"evidence":"ECO:0000255","source_location":"TOPO_DOM 21..417; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":21},{"description":"Cytoplasmic","end":913,"evidence":"ECO:0000255","source_location":"TOPO_DOM 439..913; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":439}],"transmembrane_segments":[{"description":"Helical","end":438,"evidence":"ECO:0000255","source_location":"TRANSMEM 418..438; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":418}]},"uniprot_accession":"Q08345"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000168003","evidence_rank":30,"extracellular_segments":{"records":[{"basis":"reviewed-uniprot-topological-domain","end":529,"evidence_class":"source-annotated-topology","length":425,"sequence":"DTEVDMKEVELNELEPEKQPMNAASGAAMSLAGAEKNGLVKIKVAEDEAEAAAAAKFTGLSKEELLKVAGSPGWVRTRWALLLLFWLGWLGMLAGAVVIIVRAPRCRELPAQKWWHTGALYRIGDLQAFQGHGAGNLAGLKGRLDYLSSLKVKGLVLGPIHKNQKDDVAQTDLLQIDPNFGSKEDFDSLLQSAKKKSIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAGVDGFQVRDIENLKDASSFLAEWQNITKGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLTSSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQLLRLYQLMLFTLPGTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLSLFRRLSDQ","sequence_sha256":"ba948df48c2715bfe650c4e1e165d0b4921f4e010e6d0e46b1ea0147220a21e5","start":105}],"state":"source-annotated"},"gene_symbol":"SLC3A2","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MELQPPEASIAVVSIPRQLPGSHSEAGVQGLSAGDDSELGSHCVAQTGLELLASGDPLPSASQNAEMIETGSDCVTQAGLQLLASSDPPALASKNAEVTGTMSQDTEVDMKEVELNELEPEKQPMNAASGAAMSLAGAEKNGLVKIKVAEDEAEAAAAAKFTGLSKEELLKVAGSPGWVRTRWALLLLFWLGWLGMLAGAVVIIVRAPRCRELPAQKWWHTGALYRIGDLQAFQGHGAGNLAGLKGRLDYLSSLKVKGLVLGPIHKNQKDDVAQTDLLQIDPNFGSKEDFDSLLQSAKKKSIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAGVDGFQVRDIENLKDASSFLAEWQNITKGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLTSSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQLLRLYQLMLFTLPGTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLSLFRRLSDQRSKERSLLHGDFHAFSAGPGLFSYIRHWDQNERFLVVLNFGDVGLSAGLQASDLPASASLPAKADLLLSTQPGREEGSPLELERLKLEPHEGLLLRFPYAA","length":630,"sha256":"a5e0be8a99958752bb23ac1ad9cc11d2f70a195a87ba9879108527e694222761","state":"available"},"source_refs":[{"artifact":{"bytes":13710,"format":"json","sha256":"73d2dd0844982b5c46b0c0f92154ae9823f164f9d6615530dcf74353620dd2de","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/P08195"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"P08195","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"retained-unmodeled","target_id":"T-ENSG00000168003","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":630},"entry_name":"4F2_HUMAN","gene_names":"SLC3A2 MDU1","lipidation_sites":[],"protein_names":"Amino acid transporter heavy chain SLC3A2 (4F2 cell-surface antigen heavy chain) (4F2hc) (4F2 heavy chain antigen) (Lymphocyte activation antigen 4F2 large subunit) (Solute carrier family 3 member 2) (CD antigen CD98)","raw_fields":{"lipidation":"","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:11742812}. Cell membrane {ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:15769744, ECO:0000269|PubMed:16496379, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:3476959, ECO:0000269|PubMed:3480538, ECO:0000269|PubMed:36028562, ECO:0000269|PubMed:37918808, ECO:0000269|PubMed:9829974}; Single-pass type II membrane protein {ECO:0000269|PubMed:30867591}. Cell junction {ECO:0000250|UniProtKB:P10852}. Lysosome membrane {ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:40280132}. Melanosome {ECO:0000269|PubMed:17081065}. Basolateral cell membrane {ECO:0000250|UniProtKB:P10852}. Note=Localized at the plasma membrane when associated with SLC7A5/LAT1 or SLC7A8/LAT2 (PubMed:11311135, PubMed:9751058). Localized to the apical membrane of placental syncytiotrophoblastic cells (PubMed:11742812). Recruited to lysosomes by LAPTM4B (PubMed:25998567). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Located selectively at cell-cell adhesion sites (By similarity). Colocalized with SLC7A8/LAT2 at the basolateral membrane of kidney proximal tubules and small intestine epithelia. Expressed in both luminal and abluminal membranes of brain capillary endothelial cells (By similarity). {ECO:0000250|UniProtKB:P10852, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:9751058}.","topological_domain":"TOPO_DOM 2..83; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:11121428, ECO:0000269|PubMed:30867591\"; TOPO_DOM 105..529; /note=\"Extracellular\"; /evidence=\"ECO:0000269|PubMed:11121428, ECO:0000269|PubMed:30867591\"","transmembrane":"TRANSMEM 84..104; /note=\"Helical; Signal-anchor for type II membrane protein\"; /evidence=\"ECO:0000269|PubMed:30867591\""},"signal_peptides":[],"state":"available","topological_domains":[{"description":"Cytoplasmic","end":83,"evidence":"ECO:0000269|PubMed:11121428, ECO:0000269|PubMed:30867591","source_location":"TOPO_DOM 2..83; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000269|PubMed:11121428, ECO:0000269|PubMed:30867591\"","start":2},{"description":"Extracellular","end":529,"evidence":"ECO:0000269|PubMed:11121428, ECO:0000269|PubMed:30867591","source_location":"TOPO_DOM 105..529; 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/evidence=\"ECO:0000255\"","start":163},{"description":"Extracellular","end":207,"evidence":"ECO:0000255","source_location":"TOPO_DOM 198..207; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":198},{"description":"Cytoplasmic","end":235,"evidence":"ECO:0000255","source_location":"TOPO_DOM 229..235; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":229},{"description":"Extracellular","end":268,"evidence":"ECO:0000255","source_location":"TOPO_DOM 257..268; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":257},{"description":"Cytoplasmic","end":323,"evidence":"ECO:0000255","source_location":"TOPO_DOM 290..323; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":290}],"transmembrane_segments":[{"description":"Helical","end":162,"evidence":"ECO:0000255","source_location":"TRANSMEM 142..162; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":142},{"description":"Helical","end":197,"evidence":"ECO:0000255","source_location":"TRANSMEM 177..197; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":177},{"description":"Helical","end":228,"evidence":"ECO:0000255","source_location":"TRANSMEM 208..228; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":208},{"description":"Helical","end":256,"evidence":"ECO:0000255","source_location":"TRANSMEM 236..256; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":236},{"description":"Helical","end":289,"evidence":"ECO:0000255","source_location":"TRANSMEM 269..289; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":269}]},"uniprot_accession":"Q08722"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000181143","evidence_rank":56,"extracellular_segments":{"records":[{"basis":"reviewed-uniprot-topological-domain","end":14451,"evidence_class":"source-annotated-topology","length":14451,"sequence":"MLKPSGLPGSSSPTRSLMTGSRSTKATPEMDSGLTGATLSPKTSTGAIVVTEHTLPFTSPDKTLASPTSSVVGRTTQSLGVMSSALPESTSRGMTHSEQRTSPSLSPQVNGTPSRNYPATSMVSGLSSPRTRTSSTEGNFTKEASTYTLTVETTSGPVTEKYTVPTETSTTEGDSTETPWDTRYIPVKITSPMKTFADSTASKENAPVSMTPAETTVTDSHTPGRTNPSFGTLYSSFLDLSPKGTPNSRGETSLELILSTTGYPFSSPEPGSAGHSRISTSAPLSSSASVLDNKISETSIFSGQSLTSPLSPGVPEARASTMPNSAIPFSMTLSNAETSAERVRSTISSLGTPSISTKQTAETILTFHAFAETMDIPSTHIAKTLASEWLGSPGTLGGTSTSALTTTSPSTTLVSEETNTHHSTSGKETEGTLNTSMTPLETSAPGEESEMTATLVPTLGFTTLDSKIRSPSQVSSSHPTRELRTTGSTSGRQSSSTAAHGSSDILRATTSSTSKASSWTSESTAQQFSEPQHTQWVETSPSMKTERPPASTSVAAPITTSVPSVVSGFTTLKTSSTKGIWLEETSADTLIGESTAGPTTHQFAVPTGISMTGGSSTRGSQGTTHLLTRATASSETSADLTLATNGVPVSVSPAVSKTAAGSSPPGGTKPSYTMVSSVIPETSSLQSSAFREGTSLGLTPLNTRHPFSSPEPDSAGHTKISTSIPLLSSASVLEDKVSATSTFSHHKATSSITTGTPEISTKTKPSSAVLSSMTLSNAATSPERVRNATSPLTHPSPSGEETAGSVLTLSTSAETTDSPNIHPTGTLTSESSESPSTLSLPSVSGVKTTFSSSTPSTHLFTSGEETEETSNPSVSQPETSVSRVRTTLASTSVPTPVFPTMDTWPTRSAQFSSSHLVSELRATSSTSVTNSTGSALPKISHLTGTATMSQTNRDTFNDSAAPQSTTWPETSPRFKTGLPSATTTVSTSATSLSATVMVSKFTSPATSSMEATSIREPSTTILTTETTNGPGSMAVASTNIPIGKGYITEGRLDTSHLPIGTTASSETSMDFTMAKESVSMSVSPSQSMDAAGSSTPGRTSQFVDTFSDDVYHLTSREITIPRDGTSSALTPQMTATHPPSPDPGSARSTWLGILSSSPSSPTPKVTMSSTFSTQRVTTSMIMDTVETSRWNMPNLPSTTSLTPSNIPTSGAIGKSTLVPLDTPSPATSLEASEGGLPTLSTYPESTNTPSIHLGAHASSESPSTIKLTMASVVKPGSYTPLTFPSIETHIHVSTARMAYSSGSSPEMTAPGETNTGSTWDPTTYITTTDPKDTSSAQVSTPHSVRTLRTTENHPKTESATPAAYSGSPKISSSPNLTSPATKAWTITDTTEHSTQLHYTKLAEKSSGFETQSAPGPVSVVIPTSPTIGSSTLELTSDVPGEPLVLAPSEQTTITLPMATWLSTSLTEEMASTDLDISSPSSPMSTFAIFPPMSTPSHELSKSEADTSAIRNTDSTTLDQHLGIRSLGRTGDLTTVPITPLTTTWTSVIEHSTQAQDTLSATMSPTHVTQSLKDQTSIPASASPSHLTEVYPELGTQGRSSSEATTFWKPSTDTLSREIETGPTNIQSTPPMDNTTTGSSSSGVTLGIAHLPIGTSSPAETSTNMALERRSSTATVSMAGTMGLLVTSAPGRSISQSLGRVSSVLSESTTEGVTDSSKGSSPRLNTQGNTALSSSLEPSYAEGSQMSTSIPLTSSPTTPDVEFIGGSTFWTKEVTTVMTSDISKSSARTESSSATLMSTALGSTENTGKEKLRTASMDLPSPTPSMEVTPWISLTLSNAPNTTDSLDLSHGVHTSSAGTLATDRSLNTGVTRASRLENGSDTSSKSLSMGNSTHTSMTYTEKSEVSSSIHPRPETSAPGAETTLTSTPGNRAISLTLPFSSIPVEEVISTGITSGPDINSAPMTHSPITPPTIVWTSTGTIEQSTQPLHAVSSEKVSVQTQSTPYVNSVAVSASPTHENSVSSGSSTSSPYSSASLESLDSTISRRNAITSWLWDLTTSLPTTTWPSTSLSEALSSGHSGVSNPSSTTTEFPLFSAASTSAAKQRNPETETHGPQNTAASTLNTDASSVTGLSETPVGASISSEVPLPMAITSRSDVSGLTSESTANPSLGTASSAGTKLTRTISLPTSESLVSFRMNKDPWTVSIPLGSHPTTNTETSIPVNSAGPPGLSTVASDVIDTPSDGAESIPTVSFSPSPDTEVTTISHFPEKTTHSFRTISSLTHELTSRVTPIPGDWMSSAMSTKPTGASPSITLGERRTITSAAPTTSPIVLTASFTETSTVSLDNETTVKTSDILDARKTNELPSDSSSSSDLINTSIASSTMDVTKTASISPTSISGMTASSSPSLFSSDRPQVPTSTTETNTATSPSVSSNTYSLDGGSNVGGTPSTLPPFTITHPVETSSALLAWSRPVRTFSTMVSTDTASGENPTSSNSVVTSVPAPGTWTSVGSTTDLPAMGFLKTSPAGEAHSLLASTIEPATAFTPHLSAAVVTGSSATSEASLLTTSESKAIHSSPQTPTTPTSGANWETSATPESLLVVTETSDTTLTSKILVTDTILFSTVSTPPSKFPSTGTLSGASFPTLLPDTPAIPLTATEPTSSLATSFDSTPLVTIASDSLGTVPETTLTMSETSNGDALVLKTVSNPDRSIPGITIQGVTESPLHPSSTSPSKIVAPRNTTYEGSITVALSTLPAGTTGSLVFSQSSENSETTALVDSSAGLERASVMPLTTGSQGMASSGGIRSGSTHSTGTKTFSSLPLTMNPGEVTAMSEITTNRLTATQSTAPKGIPVKPTSAESGLLTPVSASSSPSKAFASLTTAPPTWGIPQSTLTFEFSEVPSLDTKSASLPTPGQSLNTIPDSDASTASSSLSKSPEKNPRARMMTSTKAISASSFQSTGFTETPEGSASPSMAGHEPRVPTSGTGDPRYASESMSYPDPSKASSAMTSTSLASKLTTLFSTGQAARSGSSSSPISLSTEKETSFLSPTASTSRKTSLFLGPSMARQPNILVHLQTSALTLSPTSTLNMSQEEPPELTSSQTIAEEEGTTAETQTLTFTPSETPTSLLPVSSPTEPTARRKSSPETWASSISVPAKTSLVETTDGTLVTTIKMSSQAAQGNSTWPAPAEETGSSPAGTSPGSPEMSTTLKIMSSKEPSISPEIRSTVRNSPWKTPETTVPMETTVEPVTLQSTALGSGSTSISHLPTGTTSPTKSPTENMLATERVSLSPSPPEAWTNLYSGTPGGTRQSLATMSSVSLESPTARSITGTGQQSSPELVSKTTGMEFSMWHGSTGGTTGDTHVSLSTSSNILEDPVTSPNSVSSLTDKSKHKTETWVSTTAIPSTVLNNKIMAAEQQTSRSVDEAYSSTSSWSDQTSGSDITLGASPDVTNTLYITSTAQTTSLVSLPSGDQGITSLTNPSGGKTSSASSVTSPSIGLETLRANVSAVKSDIAPTAGHLSQTSSPAEVSILDVTTAPTPGISTTITTMGTNSISTTTPNPEVGMSTMDSTPATERRTTSTEHPSTWSSTAASDSWTVTDMTSNLKVARSPGTISTMHTTSFLASSTELDSMSTPHGRITVIGTSLVTPSSDASAVKTETSTSERTLSPSDTTASTPISTFSRVQRMSISVPDILSTSWTPSSTEAEDVPVSMVSTDHASTKTDPNTPLSTFLFDSLSTLDWDTGRSLSSATATTSAPQGATTPQELTLETMISPATSQLPFSIGHITSAVTPAAMARSSGVTFSRPDPTSKKAEQTSTQLPTTTSAHPGQVPRSAATTLDVIPHTAKTPDATFQRQGQTALTTEARATSDSWNEKEKSTPSAPWITEMMNSVSEDTIKEVTSSSSVLRTLNTLDINLESGTTSSPSWKSSPYERIAPSESTTDKEAIHPSTNTVETTGWVTSSEHASHSTIPAHSASSKLTSPVVTTSTREQAIVSMSTTTWPESTRARTEPNSFLTIELRDVSPYMDTSSTTQTSIISSPGSTAITKGPRTEITSSKRISSSFLAQSMRSSDSPSEAITRLSNFPAMTESGGMILAMQTSPPGATSLSAPTLDTSATASWTGTPLATTQRFTYSEKTTLFSKGPEDTSQPSPPSVEETSSSSSLVPIHATTSPSNILLTSQGHSPSSTPPVTSVFLSETSGLGKTTDMSRISLEPGTSLPPNLSSTAGEALSTYEASRDTKAIHHSADTAVTNMEATSSEYSPIPGHTKPSKATSPLVTSHIMGDITSSTSVFGSSETTEIETVSSVNQGLQERSTSQVASSATETSTVITHVSSGDATTHVTKTQATFSSGTSISSPHQFITSTNTFTDVSTNPSTSLIMTESSGVTITTQTGPTGAATQGPYLLDTSTMPYLTETPLAVTPDFMQSEKTTLISKGPKDVSWTSPPSVAETSYPSSLTPFLVTTIPPATSTLQGQHTSSPVSATSVLTSGLVKTTDMLNTSMEPVTNSPQNLNNPSNEILATLAATTDIETIHPSINKAVTNMGTASSAHVLHSTLPVSSEPSTATSPMVPASSMGDALASISIPGSETTDIEGEPTSSLTAGRKENSTLQEMNSTTESNIILSNVSVGAITEATKMEVPSFDATFIPTPAQSTKFPDIFSVASSRLSNSPPMTISTHMTTTQTGSSGATSKIPLALDTSTLETSAGTPSVVTEGFAHSKITTAMNNDVKDVSQTNPPFQDEASSPSSQAPVLVTTLPSSVAFTPQWHSTSSPVSMSSVLTSSLVKTAGKVDTSLETVTSSPQSMSNTLDDISVTSAATTDIETTHPSINTVVTNVGTTGSAFESHSTVSAYPEPSKVTSPNVTTSTMEDTTISRSIPKSSKTTRTETETTSSLTPKLRETSISQEITSSTETSTVPYKELTGATTEVSRTDVTSSSSTSFPGPDQSTVSLDISTETNTRLSTSPIMTESAEITITTQTGPHGATSQDTFTMDPSNTTPQAGIHSAMTHGFSQLDVTTLMSRIPQDVSWTSPPSVDKTSSPSSFLSSPAMTTPSLISSTLPEDKLSSPMTSLLTSGLVKITDILRTRLEPVTSSLPNFSSTSDKILATSKDSKDTKEIFPSINTEETNVKANNSGHESHSPALADSETPKATTQMVITTTVGDPAPSTSMPVHGSSETTNIKREPTYFLTPRLRETSTSQESSFPTDTSFLLSKVPTGTITEVSSTGVNSSSKISTPDHDKSTVPPDTFTGEIPRVFTSSIKTKSAEMTITTQASPPESASHSTLPLDTSTTLSQGGTHSTVTQGFPYSEVTTLMGMGPGNVSWMTTPPVEETSSVSSLMSSPAMTSPSPVSSTSPQSIPSSPLPVTALPTSVLVTTTDVLGTTSPESVTSSPPNLSSITHERPATYKDTAHTEAAMHHSTNTAVTNVGTSGSGHKSQSSVLADSETSKATPLMSTTSTLGDTSVSTSTPNISQTNQIQTEPTASLSPRLRESSTSEKTSSTTETNTAFSYVPTGAITQASRTEISSSRTSISDLDRPTIAPDISTGMITRLFTSPIMTKSAEMTVTTQTTTPGATSQGILPWDTSTTLFQGGTHSTVSQGFPHSEITTLRSRTPGDVSWMTTPPVEETSSGFSLMSPSMTSPSPVSSTSPESIPSSPLPVTALLTSVLVTTTNVLGTTSPEPVTSSPPNLSSPTQERLTTYKDTAHTEAMHASMHTNTAVANVGTSISGHESQSSVPADSHTSKATSPMGITFAMGDTSVSTSTPAFFETRIQTESTSSLIPGLRDTRTSEEINTVTETSTVLSEVPTTTTTEVSRTEVITSSRTTISGPDHSKMSPYISTETITRLSTFPFVTGSTEMAITNQTGPIGTISQATLTLDTSSTASWEGTHSPVTQRFPHSEETTTMSRSTKGVSWQSPPSVEETSSPSSPVPLPAITSHSSLYSAVSGSSPTSALPVTSLLTSGRRKTIDMLDTHSELVTSSLPSASSFSGEILTSEASTNTETIHFSENTAETNMGTTNSMHKLHSSVSIHSQPSGHTPPKVTGSMMEDAIVSTSTPGSPETKNVDRDSTSPLTPELKEDSTALVMNSTTESNTVFSSVSLDAATEVSRAEVTYYDPTFMPASAQSTKSPDISPEASSSHSNSPPLTISTHKTIATQTGPSGVTSLGQLTLDTSTIATSAGTPSARTQDFVDSETTSVMNNDLNDVLKTSPFSAEEANSLSSQAPLLVTTSPSPVTSTLQEHSTSSLVSVTSVPTPTLAKITDMDTNLEPVTRSPQNLRNTLATSEATTDTHTMHPSINTAVANVGTTSSPNEFYFTVSPDSDPYKATSAVVITSTSGDSIVSTSMPRSSAMKKIESETTFSLIFRLRETSTSQKIGSSSDTSTVFDKAFTAATTEVSRTELTSSSRTSIQGTEKPTMSPDTSTRSVTMLSTFAGLTKSEERTIATQTGPHRATSQGTLTWDTSITTSQAGTHSAMTHGFSQLDLSTLTSRVPEYISGTSPPSVEKTSSSSSLLSLPAITSPSPVPTTLPESRPSSPVHLTSLPTSGLVKTTDMLASVASLPPNLGSTSHKIPTTSEDIKDTEKMYPSTNIAVTNVGTTTSEKESYSSVPAYSEPPKVTSPMVTSFNIRDTIVSTSMPGSSEITRIEMESTFSLAHGLKGTSTSQDPIVSTEKSAVLHKLTTGATETSRTEVASSRRTSIPGPDHSTESPDISTEVIPSLPISLGITESSNMTIITRTGPPLGSTSQGTFTLDTPTTSSRAGTHSMATQEFPHSEMTTVMNKDPEILSWTIPPSIEKTSFSSSLMPSPAMTSPPVSSTLPKTIHTTPSPMTSLLTPSLVMTTDTLGTSPEPTTSSPPNLSSTSHEILTTDEDTTAIEAMHPSTSTAATNVETTSSGHGSQSSVLADSEKTKATAPMDTTSTMGHTTVSTSMSVSSETTKIKRESTYSLTPGLRETSISQNASFSTDTSIVLSEVPTGTTAEVSRTEVTSSGRTSIPGPSQSTVLPEISTRTMTRLFASPTMTESAEMTIPTQTGPSGSTSQDTLTLDTSTTKSQAKTHSTLTQRFPHSEMTTLMSRGPGDMSWQSSPSLENPSSLPSLLSLPATTSPPPISSTLPVTISSSPLPVTSLLTSSPVTTTDMLHTSPELVTSSPPKLSHTSDERLTTGKDTTNTEAVHPSTNTAASNVEIPSSGHESPSSALADSETSKATSPMFITSTQEDTTVAISTPHFLETSRIQKESISSLSPKLRETGSSVETSSAIETSAVLSEVSIGATTEISRTEVTSSSRTSISGSAESTMLPEISTTRKIIKFPTSPILAESSEMTIKTQTSPPGSTSESTFTLDTSTTPSLVITHSTMTQRLPHSEITTLVSRGAGDVPRPSSLPVEETSPPSSQLSLSAMISPSPVSSTLPASSHSSSASVTSLLTPGQVKTTEVLDASAEPETSSPPSLSSTSVEILATSEVTTDTEKIHPFSNTAVTKVGTSSSGHESPSSVLPDSETTKATSAMGTISIMGDTSVSTLTPALSNTRKIQSEPASSLTTRLRETSTSEETSLATEANTVLSKVSTGATTEVSRTEAISFSRTSMSGPEQSTMSQDISIGTIPRISASSVLTESAKMTITTQTGPSESTLESTLNLNTATTPSWVETHSIVIQGFPHPEMTTSMGRGPGGVSWPSPPFVKETSPPSSPLSLPAVTSPHPVSTTFLAHIPPSPLPVTSLLTSGPATTTDILGTSTEPGTSSSSSLSTTSHERLTTYKDTAHTEAVHPSTNTGGTNVATTSSGYKSQSSVLADSSPMCTTSTMGDTSVLTSTPAFLETRRIQTELASSLTPGLRESSGSEGTSSGTKMSTVLSKVPTGATTEISKEDVTSIPGPAQSTISPDISTRTVSWFSTSPVMTESAEITMNTHTSPLGATTQGTSTLDTSSTTSLTMTHSTISQGFSHSQMSTLMRRGPEDVSWMSPPLLEKTRPSFSLMSSPATTSPSPVSSTLPESISSSPLPVTSLLTSGLAKTTDMLHKSSEPVTNSPANLSSTSVEILATSEVTTDTEKTHPSSNRTVTDVGTSSSGHESTSFVLADSQTSKVTSPMVITSTMEDTSVSTSTPGFFETSRIQTEPTSSLTLGLRKTSSSEGTSLATEMSTVLSGVPTGATAEVSRTEVTSSSRTSISGFAQLTVSPETSTETITRLPTSSIMTESAEMMIKTQTDPPGSTPESTHTVDISTTPNWVETHSTVTQRFSHSEMTTLVSRSPGDMLWPSQSSVEETSSASSLLSLPATTSPSPVSSTLVEDFPSASLPVTSLLNPGLVITTDRMGISREPGTSSTSNLSSTSHERLTTLEDTVDTEDMQPSTHTAVTNVRTSISGHESQSSVLSDSETPKATSPMGTTYTMGETSVSISTSDFFETSRIQIEPTSSLTSGLRETSSSERISSATEGSTVLSEVPSGATTEVSRTEVISSRGTSMSGPDQFTISPDISTEAITRLSTSPIMTESAESAITIETGSPGATSEGTLTLDTSTTTFWSGTHSTASPGFSHSEMTTLMSRTPGDVPWPSLPSVEEASSVSSSLSSPAMTSTSFFSTLPESISSSPHPVTALLTLGPVKTTDMLRTSSEPETSSPPNLSSTSAEILATSEVTKDREKIHPSSNTPVVNVGTVIYKHLSPSSVLADLVTTKPTSPMATTSTLGNTSVSTSTPAFPETMMTQPTSSLTSGLREISTSQETSSATERSASLSGMPTGATTKVSRTEALSLGRTSTPGPAQSTISPEISTETITRISTPLTTTGSAEMTITPKTGHSGASSQGTFTLDTSSRASWPGTHSAATHRSPHSGMTTPMSRGPEDVSWPSRPSVEKTSPPSSLVSLSAVTSPSPLYSTPSESSHSSPLRVTSLFTPVMMKTTDMLDTSLEPVTTSPPSMNITSDESLATSKATMETEAIQLSENTAVTQMGTISARQEFYSSYPGLPEPSKVTSPVVTSSTIKDIVSTTIPASSEITRIEMESTSTLTPTPRETSTSQEIHSATKPSTVPYKALTSATIEDSMTQVMSSSRGPSPDQSTMSQDISTEVITRLSTSPIKTESTEMTITTQTGSPGATSRGTLTLDTSTTFMSGTHSTASQGFSHSQMTALMSRTPGDVPWLSHPSVEEASSASFSLSSPVMTSSSPVSSTLPDSIHSSSLPVTSLLTSGLVKTTELLGTSSEPETSSPPNLSSTSAEILAITEVTTDTEKLEMTNVVTSGYTHESPSSVLADSVTTKATSSMGITYPTGDTNVLTSTPAFSDTSRIQTKSKLSLTPGLMETSISEETSSATEKSTVLSSVPTGATTEVSRTEAISSSRTSIPGPAQSTMSSDTSMETITRISTPLTRKESTDMAITPKTGPSGATSQGTFTLDSSSTASWPGTHSATTQRFPQSVVTTPMSRGPEDVSWPSPLSVEKNSPPSSLVSSSSVTSPSPLYSTPSGSSHSSPVPVTSLFTSIMMKATDMLDASLEPETTSAPNMNITSDESLAASKATTETEAIHVFENTAASHVETTSATEELYSSSPGFSEPTKVISPVVTSSSIRDNMVSTTMPGSSGITRIEIESMSSLTPGLRETRTSQDITSSTETSTVLYKMPSGATPEVSRTEVMPSSRTSIPGPAQSTMSLDISDEVVTRLSTSPIMTESAEITITTQTGYSLATSQVTLPLGTSMTFLSGTHSTMSQGLSHSEMTNLMSRGPESLSWTSPRFVETTRSSSSLTSLPLTTSLSPVSSTLLDSSPSSPLPVTSLILPGLVKTTEVLDTSSEPKTSSSPNLSSTSVEIPATSEIMTDTEKIHPSSNTAVAKVRTSSSVHESHSSVLADSETTITIPSMGITSAVDDTTVFTSNPAFSETRRIPTEPTFSLTPGFRETSTSEETTSITETSAVLYGVPTSATTEVSMTEIMSSNRIHIPDSDQSTMSPDIITEVITRLSSSSMMSESTQMTITTQKSSPGATAQSTLTLATTTAPLARTHSTVPPRFLHSEMTTLMSRSPENPSWKSSLFVEKTSSSSSLLSLPVTTSPSVSSTLPQSIPSSSFSVTSLLTPGMVKTTDTSTEPGTSLSPNLSGTSVEILAASEVTTDTEKIHPSSSMAVTNVGTTSSGHELYSSVSIHSEPSKATYPVGTPSSMAETSISTSMPANFETTGFEAEPFSHLTSGFRKTNMSLDTSSVTPTNTPSSPGSTHLLQSSKTDFTSSAKTSSPDWPPASQYTEIPVDIITPFNASPSITESTGITSFPESRFTMSVTESTHHLSTDLLPSAETISTGTVMPSLSEAMTSFATTGVPRAISGSGSPFSRTESGPGDATLSTIAESLPSSTPVPFSSSTFTTTDSSTIPALHEITSSSATPYRVDTSLGTESSTTEGRLVMVSTLDTSSQPGRTSSSPILDTRMTESVELGTVTSAYQVPSLSTRLTRTDGIMEHITKIPNEAAHRGTIRPVKGPQTSTSPASPKGLHTGGTKRMETTTTALKTTTTALKTTSRATLTTSVYTPTLGTLTPLNASMQMASTIPTEMMITTPYVFPDVPETTSSLATSLGAETSTALPRTTPSVFNRESETTASLVSRSGAERSPVIQTLDVSSSEPDTTASWVIHPAETIPTVSKTTPNFFHSELDTVSSTATSHGADVSSAIPTNISPSELDALTPLVTISGTDTSTTFPTLTKSPHETETRTTWLTHPAETSSTIPRTIPNFSHHESDATPSIATSPGAETSSAIPIMTVSPGAEDLVTSQVTSSGTDRNMTIPTLTLSPGEPKTIASLVTHPEAQTSSAIPTSTISPAVSRLVTSMVTSLAAKTSTTNRALTNSPGEPATTVSLVTHPAQTSPTVPWTTSIFFHSKSDTTPSMTTSHGAESSSAVPTPTVSTEVPGVVTPLVTSSRAVISTTIPILTLSPGEPETTPSMATSHGEEASSAIPTPTVSPGVPGVVTSLVTSSRAVTSTTIPILTFSLGEPETTPSMATSHGTEAGSAVPTVLPEVPGMVTSLVASSRAVTSTTLPTLTLSPGEPETTPSMATSHGAEASSTVPTVSPEVPGVVTSLVTSSSGVNSTSIPTLILSPGELETTPSMATSHGAEASSAVPTPTVSPGVSGVVTPLVTSSRAVTSTTIPILTLSSSEPETTPSMATSHGVEASSAVLTVSPEVPGMVTSLVTSSRAVTSTTIPTLTISSDEPETTTSLVTHSEAKMISAIPTLAVSPTVQGLVTSLVTSSGSETSAFSNLTVASSQPETIDSWVAHPGTEASSVVPTLTVSTGEPFTNISLVTHPAESSSTLPRTTSRFSHSELDTMPSTVTSPEAESSSAISTTISPGIPGVLTSLVTSSGRDISATFPTVPESPHESEATASWVTHPAVTSTTVPRTTPNYSHSEPDTTPSIATSPGAEATSDFPTITVSPDVPDMVTSQVTSSGTDTSITIPTLTLSSGEPETTTSFITYSETHTSSAIPTLPVSPGASKMLTSLVISSGTDSTTTFPTLTETPYEPETTAIQLIHPAETNTMVPRTTPKFSHSKSDTTLPVAITSPGPEASSAVSTTTISPDMSDLVTSLVPSSGTDTSTTFPTLSETPYEPETTATWLTHPAETSTTVSGTIPNFSHRGSDTAPSMVTSPGVDTRSGVPTTTIPPSIPGVVTSQVTSSATDTSTAIPTLTPSPGEPETTASSATHPGTQTGFTVPIRTVPSSEPDTMASWVTHPPQTSTPVSRTTSSFSHSSPDATPVMATSPRTEASSAVLTTISPGAPEMVTSQITSSGAATSTTVPTLTHSPGMPETTALLSTHPRTETSKTFPASTVFPQVSETTASLTIRPGAETSTALPTQTTSSLFTLLVTGTSRVDLSPTASPGVSAKTAPLSTHPGTETSTMIPTSTLSLGLLETTGLLATSSSAETSTSTLTLTVSPAVSGLSSASITTDKPQTVTSWNTETSPSVTSVGPPEFSRTVTGTTMTLIPSEMPTPPKTSHGEGVSPTTILRTTMVEATNLATTGSSPTVAKTTTTFNTLAGSLFTPLTTPGMSTLASESVTSRTSYNHRSWISTTSSYNRRYWTPATSTPVTSTFSPGISTSSIPSSTAATVPFMVPFTLNFTITNLQYEEDMRHPGSRKFNATERELQGLLKPLFRNSSLEYLYSGCRLASLRPEKDSSATAVDAICTHRPDPEDLGLDRERLYWELSNLTNGIQELGPYTLDRNSLYVNGFTHRSSMPTTSTPGTSTVDVGTSGTPSSSPSPTTAGPLLMPFTLNFTITNLQYEEDMRRTGSRKFNTMESVLQGLLKPLFKNTSVGPLYSGCRLTLLRPEKDGAATGVDAICTHRLDPKSPGLNREQLYWELSKLTNDIEELGPYTLDRNSLYVNGFTHQSSVSTTSTPGTSTVDLRTSGTPSSLSSPTIMAAGPLLVPFTLNFTITNLQYGEDMGHPGSRKFNTTERVLQGLLGPIFKNTSVGPLYSGCRLTSLRSEKDGAATGVDAICIHHLDPKSPGLNRERLYWELSQLTNGIKELGPYTLDRNSLYVNGFTHRTSVPTSSTPGTSTVDLGTSGTPFSLPSPATAGPLLVLFTLNFTITNLKYEEDMHRPGSRKFNTTERVLQTLLGPMFKNTSVGLLYSGCRLTLLRSEKDGAATGVDAICTHRLDPKSPGVDREQLYWELSQLTNGIKELGPYTLDRNSLYVNGFTHWIPVPTSSTPGTSTVDLGSGTPSSLPSPTTAGPLLVPFTLNFTITNLKYEEDMHCPGSRKFNTTERVLQSLLGPMFKNTSVGPLYSGCRLTLLRSEKDGAATGVDAICTHRLDPKSPGVDREQLYWELSQLTNGIKELGPYTLDRNSLYVNGFTHQTSAPNTSTPGTSTVDLGTSGTPSSLPSPTSAGPLLVPFTLNFTITNLQYEEDMHHPGSRKFNTTERVLQGLLGPMFKNTSVGLLYSGCRLTLLRPEKNGAATGMDAICSHRLDPKSPGLNREQLYWELSQLTHGIKELGPYTLDRNSLYVNGFTHRSSVAPTSTPGTSTVDLGTSGTPSSLPSPTTAVPLLVPFTLNFTITNLQYGEDMRHPGSRKFNTTERVLQGLLGPLFKNSSVGPLYSGCRLISLRSEKDGAATGVDAICTHHLNPQSPGLDREQLYWQLSQMTNGIKELGPYTLDRNSLYVNGFTHRSSGLTTSTPWTSTVDLGTSGTPSPVPSPTTTGPLLVPFTLNFTITNLQYEENMGHPGSRKFNITESVLQGLLKPLFKSTSVGPLYSGCRLTLLRPEKDGVATRVDAICTHRPDPKIPGLDRQQLYWELSQLTHSITELGPYTLDRDSLYVNGFTQRSSVPTTSTPGTFTVQPETSETPSSLPGPTATGPVLLPFTLNFTITNLQYEEDMRRPGSRKFNTTERVLQGLLMPLFKNTSVSSLYSGCRLTLLRPEKDGAATRVDAVCTHRPDPKSPGLDRERLYWKLSQLTHGITELGPYTLDRHSLYVNGFTHQSSMTTTRTPDTSTMHLATSRTPASLSGPMTASPLLVLFTINFTITNLRYEENMHHPGSRKFNTTERVLQGLLRPVFKNTSVGPLYSGCRLTLLRPKKDGAATKVDAICTYRPDPKSPGLDREQLYWELSQLTHSITELGPYTLDRDSLYVNGFTQRSSVPTTSIPGTPTVDLGTSGTPVSKPGPSAASPLLVLFTLNFTITNLRYEENMQHPGSRKFNTTERVLQGLLRSLFKSTSVGPLYSGCRLTLLRPEKDGTATGVDAICTHHPDPKSPRLDREQLYWELSQLTHNITELGPYALDNDSLFVNGFTHRSSVSTTSTPGTPTVYLGASKTPASIFGPSAASHLLILFTLNFTITNLRYEENMWPGSRKFNTTERVLQGLLRPLFKNTSVGPLYSGCRLTLLRPEKDGEATGVDAICTHRPDPTGPGLDREQLYLELSQLTHSITELGPYTLDRDSLYVNGFTHRSSVPTTSTGVVSEEPFTLNFTINNLRYMADMGQPGSLKFNITDNVMQHLLSPLFQRSSLGARYTGCRVIALRSVKNGAETRVDLLCTYLQPLSGPGLPIKQVFHELSQQTHGITRLGPYSLDKDSLYLNGYNEPGPDEPPTTPKPATTFLPPLSEATTAMGYHLKTLTLNFTISNLQYSPDMGKGSATFNSTEGVLQHLLRPLFQKSSMGPFYLGCQLISLRPEKDGAATGVDTTCTYHPDPVGPGLDIQQLYWELSQLTHGVTQLGFYVLDRDSLFINGYAPQNLSIRGEYQINFHIVNWNLSNPDPTSSEYITLLRDIQDKVTTLYKGSQLHDTFRFCLVTNLTMDSVLVTVKALFSSNLDPSLVEQVFLDKTLNASFHWLGSTYQLVDIHVTEMESSVYQPTSSSSTQHFYLNFTITNLPYSQDKAQPGTTNYQRNKRNIEDALNQLFRNSSIKSYFSDCQVSTFRSVPNRHHTGVDSLCNFSPLARRVDRVAIYEEFLRMTRNGTQLQNFTLDRSSVLVDGYSPNRNEPLTGNSDLP","sequence_sha256":"e9d873eb4d0dd31f72aff5596fbb063cfc72adac7703d8fb4033cbd2a6913247","start":1}],"state":"source-annotated"},"gene_symbol":"MUC16","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MLKPSGLPGSSSPTRSLMTGSRSTKATPEMDSGLTGATLSPKTSTGAIVVTEHTLPFTSPDKTLASPTSSVVGRTTQSLGVMSSALPESTSRGMTHSEQRTSPSLSPQVNGTPSRNYPATSMVSGLSSPRTRTSSTEGNFTKEASTYTLTVETTSGPVTEKYTVPTETSTTEGDSTETPWDTRYIPVKITSPMKTFADSTASKENAPVSMTPAETTVTDSHTPGRTNPSFGTLYSSFLDLSPKGTPNSRGETSLELILSTTGYPFSSPEPGSAGHSRISTSAPLSSSASVLDNKISETSIFSGQSLTSPLSPGVPEARASTMPNSAIPFSMTLSNAETSAERVRSTISSLGTPSISTKQTAETILTFHAFAETMDIPSTHIAKTLASEWLGSPGTLGGTSTSALTTTSPSTTLVSEETNTHHSTSGKETEGTLNTSMTPLETSAPGEESEMTATLVPTLGFTTLDSKIRSPSQVSSSHPTRELRTTGSTSGRQSSSTAAHGSSDILRATTSSTSKASSWTSESTAQQFSEPQHTQWVETSPSMKTERPPASTSVAAPITTSVPSVVSGFTTLKTSSTKGIWLEETSADTLIGESTAGPTTHQFAVPTGISMTGGSSTRGSQGTTHLLTRATASSETSADLTLATNGVPVSVSPAVSKTAAGSSPPGGTKPSYTMVSSVIPETSSLQSSAFREGTSLGLTPLNTRHPFSSPEPDSAGHTKISTSIPLLSSASVLEDKVSATSTFSHHKATSSITTGTPEISTKTKPSSAVLSSMTLSNAATSPERVRNATSPLTHPSPSGEETAGSVLTLSTSAETTDSPNIHPTGTLTSESSESPSTLSLPSVSGVKTTFSSSTPSTHLFTSGEETEETSNPSVSQPETSVSRVRTTLASTSVPTPVFPTMDTWPTRSAQFSSSHLVSELRATSSTSVTNSTGSALPKISHLTGTATMSQTNRDTFNDSAAPQSTTWPETSPRFKTGLPSATTTVSTSATSLSATVMVSKFTSPATSSMEATSIREPSTTILTTETTNGPGSMAVASTNIPIGKGYITEGRLDTSHLPIGTTASSETSMDFTMAKESVSMSVSPSQSMDAAGSSTPGRTSQFVDTFSDDVYHLTSREITIPRDGTSSALTPQMTATHPPSPDPGSARSTWLGILSSSPSSPTPKVTMSSTFSTQRVTTSMIMDTVETSRWNMPNLPSTTSLTPSNIPTSGAIGKSTLVPLDTPSPATSLEASEGGLPTLSTYPESTNTPSIHLGAHASSESPSTIKLTMASVVKPGSYTPLTFPSIETHIHVSTARMAYSSGSSPEMTAPGETNTGSTWDPTTYITTTDPKDTSSAQVSTPHSVRTLRTTENHPKTESATPAAYSGSPKISSSPNLTSPATKAWTITDTTEHSTQLHYTKLAEKSSGFETQSAPGPVSVVIPTSPTIGSSTLELTSDVPGEPLVLAPSEQTTITLPMATWLSTSLTEEMASTDLDISSPSSPMSTFAIFPPMSTPSHELSKSEADTSAIRNTDSTTLDQHLGIRSLGRTGDLTTVPITPLTTTWTSVIEHSTQAQDTLSATMSPTHVTQSLKDQTSIPASASPSHLTEVYPELGTQGRSSSEATTFWKPSTDTLSREIETGPTNIQSTPPMDNTTTGSSSSGVTLGIAHLPIGTSSPAETSTNMALERRSSTATVSMAGTMGLLVTSAPGRSISQSLGRVSSVLSESTTEGVTDSSKGSSPRLNTQGNTALSSSLEPSYAEGSQMSTSIPLTSSPTTPDVEFIGGSTFWTKEVTTVMTSDISKSSARTESSSATLMSTALGSTENTGKEKLRTASMDLPSPTPSMEVTPWISLTLSNAPNTTDSLDLSHGVHTSSAGTLATDRSLNTGVTRASRLENGSDTSSKSLSMGNSTHTSMTYTEKSEVSSSIHPRPETSAPGAETTLTSTPGNRAISLTLPFSSIPVEEVISTGITSGPDINSAPMTHSPITPPTIVWTSTGTIEQSTQPLHAVSSEKVSVQTQSTPYVNSVAVSASPTHENSVSSGSSTSSPYSSASLESLDSTISRRNAITSWLWDLTTSLPTTTWPSTSLSEALSSGHSGVSNPSSTTTEFPLFSAASTSAAKQRNPETETHGPQNTAASTLNTDASSVTGLSETPVGASISSEVPLPMAITSRSDVSGLTSESTANPSLGTASSAGTKLTRTISLPTSESLVSFRMNKDPWTVSIPLGSHPTTNTETSIPVNSAGPPGLSTVASDVIDTPSDGAESIPTVSFSPSPDTEVTTISHFPEKTTHSFRTISSLTHELTSRVTPIPGDWMSSAMSTKPTGASPSITLGERRTITSAAPTTSPIVLTASFTETSTVSLDNETTVKTSDILDARKTNELPSDSSSSSDLINTSIASSTMDVTKTASISPTSISGMTASSSPSLFSSDRPQVPTSTTETNTATSPSVSSNTYSLDGGSNVGGTPSTLPPFTITHPVETSSALLAWSRPVRTFSTMVSTDTASGENPTSSNSVVTSVPAPGTWTSVGSTTDLPAMGFLKTSPAGEAHSLLASTIEPATAFTPHLSAAVVTGSSATSEASLLTTSESKAIHSSPQTPTTPTSGANWETSATPESLLVVTETSDTTLTSKILVTDTILFSTVSTPPSKFPSTGTLSGASFPTLLPDTPAIPLTATEPTSSLATSFDSTPLVTIASDSLGTVPETTLTMSETSNGDALVLKTVSNPDRSIPGITIQGVTESPLHPSSTSPSKIVAPRNTTYEGSITVALSTLPAGTTGSLVFSQSSENSETTALVDSSAGLERASVMPLTTGSQGMASSGGIRSGSTHSTGTKTFSSLPLTMNPGEVTAMSEITTNRLTATQSTAPKGIPVKPTSAESGLLTPVSASSSPSKAFASLTTAPPTWGIPQSTLTFEFSEVPSLDTKSASLPTPGQSLNTIPDSDASTASSSLSKSPEKNPRARMMTSTKAISASSFQSTGFTETPEGSASPSMAGHEPRVPTSGTGDPRYASESMSYPDPSKASSAMTSTSLASKLTTLFSTGQAARSGSSSSPISLSTEKETSFLSPTASTSRKTSLFLGPSMARQPNILVHLQTSALTLSPTSTLNMSQEEPPELTSSQTIAEEEGTTAETQTLTFTPSETPTSLLPVSSPTEPTARRKSSPETWASSISVPAKTSLVETTDGTLVTTIKMSSQAAQGNSTWPAPAEETGSSPAGTSPGSPEMSTTLKIMSSKEPSISPEIRSTVRNSPWKTPETTVPMETTVEPVTLQSTALGSGSTSISHLPTGTTSPTKSPTENMLATERVSLSPSPPEAWTNLYSGTPGGTRQSLATMSSVSLESPTARSITGTGQQSSPELVSKTTGMEFSMWHGSTGGTTGDTHVSLSTSSNILEDPVTSPNSVSSLTDKSKHKTETWVSTTAIPSTVLNNKIMAAEQQTSRSVDEAYSSTSSWSDQTSGSDITLGASPDVTNTLYITSTAQTTSLVSLPSGDQGITSLTNPSGGKTSSASSVTSPSIGLETLRANVSAVKSDIAPTAGHLSQTSSPAEVSILDVTTAPTPGISTTITTMGTNSISTTTPNPEVGMSTMDSTPATERRTTSTEHPSTWSSTAASDSWTVTDMTSNLKVARSPGTISTMHTTSFLASSTELDSMSTPHGRITVIGTSLVTPSSDASAVKTETSTSERTLSPSDTTASTPISTFSRVQRMSISVPDILSTSWTPSSTEAEDVPVSMVSTDHASTKTDPNTPLSTFLFDSLSTLDWDTGRSLSSATATTSAPQGATTPQELTLETMISPATSQLPFSIGHITSAVTPAAMARSSGVTFSRPDPTSKKAEQTSTQLPTTTSAHPGQVPRSAATTLDVIPHTAKTPDATFQRQGQTALTTEARATSDSWNEKEKSTPSAPWITEMMNSVSEDTIKEVTSSSSVLRTLNTLDINLESGTTSSPSWKSSPYERIAPSESTTDKEAIHPSTNTVETTGWVTSSEHASHSTIPAHSASSKLTSPVVTTSTREQAIVSMSTTTWPESTRARTEPNSFLTIELRDVSPYMDTSSTTQTSIISSPGSTAITKGPRTEITSSKRISSSFLAQSMRSSDSPSEAITRLSNFPAMTESGGMILAMQTSPPGATSLSAPTLDTSATASWTGTPLATTQRFTYSEKTTLFSKGPEDTSQPSPPSVEETSSSSSLVPIHATTSPSNILLTSQGHSPSSTPPVTSVFLSETSGLGKTTDMSRISLEPGTSLPPNLSSTAGEALSTYEASRDTKAIHHSADTAVTNMEATSSEYSPIPGHTKPSKATSPLVTSHIMGDITSSTSVFGSSETTEIETVSSVNQGLQERSTSQVASSATETSTVITHVSSGDATTHVTKTQATFSSGTSISSPHQFITSTNTFTDVSTNPSTSLIMTESSGVTITTQTGPTGAATQGPYLLDTSTMPYLTETPLAVTPDFMQSEKTTLISKGPKDVSWTSPPSVAETSYPSSLTPFLVTTIPPATSTLQGQHTSSPVSATSVLTSGLVKTTDMLNTSMEPVTNSPQNLNNPSNEILATLAATTDIETIHPSINKAVTNMGTASSAHVLHSTLPVSSEPSTATSPMVPASSMGDALASISIPGSETTDIEGEPTSSLTAGRKENSTLQEMNSTTESNIILSNVSVGAITEATKMEVPSFDATFIPTPAQSTKFPDIFSVASSRLSNSPPMTISTHMTTTQTGSSGATSKIPLALDTSTLETSAGTPSVVTEGFAHSKITTAMNNDVKDVSQTNPPFQDEASSPSSQAPVLVTTLPSSVAFTPQWHSTSSPVSMSSVLTSSLVKTAGKVDTSLETVTSSPQSMSNTLDDISVTSAATTDIETTHPSINTVVTNVGTTGSAFESHSTVSAYPEPSKVTSPNVTTSTMEDTTISRSIPKSSKTTRTETETTSSLTPKLRETSISQEITSSTETSTVPYKELTGATTEVSRTDVTSSSSTSFPGPDQSTVSLDISTETNTRLSTSPIMTESAEITITTQTGPHGATSQDTFTMDPSNTTPQAGIHSAMTHGFSQLDVTTLMSRIPQDVSWTSPPSVDKTSSPSSFLSSPAMTTPSLISSTLPEDKLSSPMTSLLTSGLVKITDILRTRLEPVTSSLPNFSSTSDKILATSKDSKDTKEIFPSINTEETNVKANNSGHESHSPALADSETPKATTQMVITTTVGDPAPSTSMPVHGSSETTNIKREPTYFLTPRLRETSTSQESSFPTDTSFLLSKVPTGTITEVSSTGVNSSSKISTPDHDKSTVPPDTFTGEIPRVFTSSIKTKSAEMTITTQASPPESASHSTLPLDTSTTLSQGGTHSTVTQGFPYSEVTTLMGMGPGNVSWMTTPPVEETSSVSSLMSSPAMTSPSPVSSTSPQSIPSSPLPVTALPTSVLVTTTDVLGTTSPESVTSSPPNLSSITHERPATYKDTAHTEAAMHHSTNTAVTNVGTSGSGHKSQSSVLADSETSKATPLMSTTSTLGDTSVSTSTPNISQTNQIQTEPTASLSPRLRESSTSEKTSSTTETNTAFSYVPTGAITQASRTEISSSRTSISDLDRPTIAPDISTGMITRLFTSPIMTKSAEMTVTTQTTTPGATSQGILPWDTSTTLFQGGTHSTVSQGFPHSEITTLRSRTPGDVSWMTTPPVEETSSGFSLMSPSMTSPSPVSSTSPESIPSSPLPVTALLTSVLVTTTNVLGTTSPEPVTSSPPNLSSPTQERLTTYKDTAHTEAMHASMHTNTAVANVGTSISGHESQSSVPADSHTSKATSPMGITFAMGDTSVSTSTPAFFETRIQTESTSSLIPGLRDTRTSEEINTVTETSTVLSEVPTTTTTEVSRTEVITSSRTTISGPDHSKMSPYISTETITRLSTFPFVTGSTEMAITNQTGPIGTISQATLTLDTSSTASWEGTHSPVTQRFPHSEETTTMSRSTKGVSWQSPPSVEETSSPSSPVPLPAITSHSSLYSAVSGSSPTSALPVTSLLTSGRRKTIDMLDTHSELVTSSLPSASSFSGEILTSEASTNTETIHFSENTAETNMGTTNSMHKLHSSVSIHSQPSGHTPPKVTGSMMEDAIVSTSTPGSPETKNVDRDSTSPLTPELKEDSTALVMNSTTESNTVFSSVSLDAATEVSRAEVTYYDPTFMPASAQSTKSPDISPEASSSHSNSPPLTISTHKTIATQTGPSGVTSLGQLTLDTSTIATSAGTPSARTQDFVDSETTSVMNNDLNDVLKTSPFSAEEANSLSSQAPLLVTTSPSPVTSTLQEHSTSSLVSVTSVPTPTLAKITDMDTNLEPVTRSPQNLRNTLATSEATTDTHTMHPSINTAVANVGTTSSPNEFYFTVSPDSDPYKATSAVVITSTSGDSIVSTSMPRSSAMKKIESETTFSLIFRLRETSTSQKIGSSSDTSTVFDKAFTAATTEVSRTELTSSSRTSIQGTEKPTMSPDTSTRSVTMLSTFAGLTKSEERTIATQTGPHRATSQGTLTWDTSITTSQAGTHSAMTHGFSQLDLSTLTSRVPEYISGTSPPSVEKTSSSSSLLSLPAITSPSPVPTTLPESRPSSPVHLTSLPTSGLVKTTDMLASVASLPPNLGSTSHKIPTTSEDIKDTEKMYPSTNIAVTNVGTTTSEKESYSSVPAYSEPPKVTSPMVTSFNIRDTIVSTSMPGSSEITRIEMESTFSLAHGLKGTSTSQDPIVSTEKSAVLHKLTTGATETSRTEVASSRRTSIPGPDHSTESPDISTEVIPSLPISLGITESSNMTIITRTGPPLGSTSQGTFTLDTPTTSSRAGTHSMATQEFPHSEMTTVMNKDPEILSWTIPPSIEKTSFSSSLMPSPAMTSPPVSSTLPKTIHTTPSPMTSLLTPSLVMTTDTLGTSPEPTTSSPPNLSSTSHEILTTDEDTTAIEAMHPSTSTAATNVETTSSGHGSQSSVLADSEKTKATAPMDTTSTMGHTTVSTSMSVSSETTKIKRESTYSLTPGLRETSISQNASFSTDTSIVLSEVPTGTTAEVSRTEVTSSGRTSIPGPSQSTVLPEISTRTMTRLFASPTMTESAEMTIPTQTGPSGSTSQDTLTLDTSTTKSQAKTHSTLTQRFPHSEMTTLMSRGPGDMSWQSSPSLENPSSLPSLLSLPATTSPPPISSTLPVTISSSPLPVTSLLTSSPVTTTDMLHTSPELVTSSPPKLSHTSDERLTTGKDTTNTEAVHPSTNTAASNVEIPSSGHESPSSALADSETSKATSPMFITSTQEDTTVAISTPHFLETSRIQKESISSLSPKLRETGSSVETSSAIETSAVLSEVSIGATTEISRTEVTSSSRTSISGSAESTMLPEISTTRKIIKFPTSPILAESSEMTIKTQTSPPGSTSESTFTLDTSTTPSLVITHSTMTQRLPHSEITTLVSRGAGDVPRPSSLPVEETSPPSSQLSLSAMISPSPVSSTLPASSHSSSASVTSLLTPGQVKTTEVLDASAEPETSSPPSLSSTSVEILATSEVTTDTEKIHPFSNTAVTKVGTSSSGHESPSSVLPDSETTKATSAMGTISIMGDTSVSTLTPALSNTRKIQSEPASSLTTRLRETSTSEETSLATEANTVLSKVSTGATTEVSRTEAISFSRTSMSGPEQSTMSQDISIGTIPRISASSVLTESAKMTITTQTGPSESTLESTLNLNTATTPSWVETHSIVIQGFPHPEMTTSMGRGPGGVSWPSPPFVKETSPPSSPLSLPAVTSPHPVSTTFLAHIPPSPLPVTSLLTSGPATTTDILGTSTEPGTSSSSSLSTTSHERLTTYKDTAHTEAVHPSTNTGGTNVATTSSGYKSQSSVLADSSPMCTTSTMGDTSVLTSTPAFLETRRIQTELASSLTPGLRESSGSEGTSSGTKMSTVLSKVPTGATTEISKEDVTSIPGPAQSTISPDISTRTVSWFSTSPVMTESAEITMNTHTSPLGATTQGTSTLDTSSTTSLTMTHSTISQGFSHSQMSTLMRRGPEDVSWMSPPLLEKTRPSFSLMSSPATTSPSPVSSTLPESISSSPLPVTSLLTSGLAKTTDMLHKSSEPVTNSPANLSSTSVEILATSEVTTDTEKTHPSSNRTVTDVGTSSSGHESTSFVLADSQTSKVTSPMVITSTMEDTSVSTSTPGFFETSRIQTEPTSSLTLGLRKTSSSEGTSLATEMSTVLSGVPTGATAEVSRTEVTSSSRTSISGFAQLTVSPETSTETITRLPTSSIMTESAEMMIKTQTDPPGSTPESTHTVDISTTPNWVETHSTVTQRFSHSEMTTLVSRSPGDMLWPSQSSVEETSSASSLLSLPATTSPSPVSSTLVEDFPSASLPVTSLLNPGLVITTDRMGISREPGTSSTSNLSSTSHERLTTLEDTVDTEDMQPSTHTAVTNVRTSISGHESQSSVLSDSETPKATSPMGTTYTMGETSVSISTSDFFETSRIQIEPTSSLTSGLRETSSSERISSATEGSTVLSEVPSGATTEVSRTEVISSRGTSMSGPDQFTISPDISTEAITRLSTSPIMTESAESAITIETGSPGATSEGTLTLDTSTTTFWSGTHSTASPGFSHSEMTTLMSRTPGDVPWPSLPSVEEASSVSSSLSSPAMTSTSFFSTLPESISSSPHPVTALLTLGPVKTTDMLRTSSEPETSSPPNLSSTSAEILATSEVTKDREKIHPSSNTPVVNVGTVIYKHLSPSSVLADLVTTKPTSPMATTSTLGNTSVSTSTPAFPETMMTQPTSSLTSGLREISTSQETSSATERSASLSGMPTGATTKVSRTEALSLGRTSTPGPAQSTISPEISTETITRISTPLTTTGSAEMTITPKTGHSGASSQGTFTLDTSSRASWPGTHSAATHRSPHSGMTTPMSRGPEDVSWPSRPSVEKTSPPSSLVSLSAVTSPSPLYSTPSESSHSSPLRVTSLFTPVMMKTTDMLDTSLEPVTTSPPSMNITSDESLATSKATMETEAIQLSENTAVTQMGTISARQEFYSSYPGLPEPSKVTSPVVTSSTIKDIVSTTIPASSEITRIEMESTSTLTPTPRETSTSQEIHSATKPSTVPYKALTSATIEDSMTQVMSSSRGPSPDQSTMSQDISTEVITRLSTSPIKTESTEMTITTQTGSPGATSRGTLTLDTSTTFMSGTHSTASQGFSHSQMTALMSRTPGDVPWLSHPSVEEASSASFSLSSPVMTSSSPVSSTLPDSIHSSSLPVTSLLTSGLVKTTELLGTSSEPETSSPPNLSSTSAEILAITEVTTDTEKLEMTNVVTSGYTHESPSSVLADSVTTKATSSMGITYPTGDTNVLTSTPAFSDTSRIQTKSKLSLTPGLMETSISEETSSATEKSTVLSSVPTGATTEVSRTEAISSSRTSIPGPAQSTMSSDTSMETITRISTPLTRKESTDMAITPKTGPSGATSQGTFTLDSSSTASWPGTHSATTQRFPQSVVTTPMSRGPEDVSWPSPLSVEKNSPPSSLVSSSSVTSPSPLYSTPSGSSHSSPVPVTSLFTSIMMKATDMLDASLEPETTSAPNMNITSDESLAASKATTETEAIHVFENTAASHVETTSATEELYSSSPGFSEPTKVISPVVTSSSIRDNMVSTTMPGSSGITRIEIESMSSLTPGLRETRTSQDITSSTETSTVLYKMPSGATPEVSRTEVMPSSRTSIPGPAQSTMSLDISDEVVTRLSTSPIMTESAEITITTQTGYSLATSQVTLPLGTSMTFLSGTHSTMSQGLSHSEMTNLMSRGPESLSWTSPRFVETTRSSSSLTSLPLTTSLSPVSSTLLDSSPSSPLPVTSLILPGLVKTTEVLDTSSEPKTSSSPNLSSTSVEIPATSEIMTDTEKIHPSSNTAVAKVRTSSSVHESHSSVLADSETTITIPSMGITSAVDDTTVFTSNPAFSETRRIPTEPTFSLTPGFRETSTSEETTSITETSAVLYGVPTSATTEVSMTEIMSSNRIHIPDSDQSTMSPDIITEVITRLSSSSMMSESTQMTIT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Note=Detected in both cell membrane and cytoplasm in neurons. {ECO:0000250|UniProtKB:Q8R0I0}.; SUBCELLULAR LOCATION: [Isoform 2]: Apical cell membrane {ECO:0000269|PubMed:33432184}.","topological_domain":"TOPO_DOM 18..740; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 762..805; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 741..761; /note=\"Helical\"; /evidence=\"ECO:0000255|PROSITE-ProRule:PRU01354\""},"signal_peptides":[{"description":null,"end":17,"evidence":"ECO:0000255","source_location":"SIGNAL 1..17; /evidence=\"ECO:0000255\"","start":1}],"state":"available","topological_domains":[{"description":"Extracellular","end":740,"evidence":"ECO:0000255","source_location":"TOPO_DOM 18..740; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":18},{"description":"Cytoplasmic","end":805,"evidence":"ECO:0000255","source_location":"TOPO_DOM 762..805; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":762}],"transmembrane_segments":[{"description":"Helical","end":761,"evidence":"ECO:0000255|PROSITE-ProRule:PRU01354","source_location":"TRANSMEM 741..761; 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extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000142627","evidence_rank":65,"extracellular_segments":{"records":[{"basis":"reviewed-uniprot-topological-domain","end":537,"evidence_class":"source-annotated-topology","length":514,"sequence":"AQGKEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMYSVCNVMSGDQDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRKGFYLAFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGGEEPRMHCAVDGEWLVPIGQCLCQAGYEKVEDACQACSPGFFKFEASESPCLECPEHTLPSPEGATSCECEEGFFRAPQDPASMPCTRPPSAPHYLTAVGMGAKVELRWTPPQDSGGREDIVYSVTCEQCWPESGECGPCEASVRYSEPPHGLTRTSVTVSDLEPHMNYTFTVEARNGVSGLVTSRSFRTASVSINQTEPPKVRLEGRSTTSLSVSWSIPPPQQSRVWKYEVTYRKKGDSNSYNVRRTEGFSVTLDDLAPDTTYLVQVQALTQEGQGAGSKVHEFQTLSPEGSGNLAV","sequence_sha256":"895a31decb9405460cd84a84412adebeac029f89d8f9d922aff8006571b9f5e9","start":24}],"state":"source-annotated"},"gene_symbol":"EPHA2","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MELQAARACFALLWGCALAAAAAAQGKEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMYSVCNVMSGDQDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRKGFYLAFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGGEEPRMHCAVDGEWLVPIGQCLCQAGYEKVEDACQACSPGFFKFEASESPCLECPEHTLPSPEGATSCECEEGFFRAPQDPASMPCTRPPSAPHYLTAVGMGAKVELRWTPPQDSGGREDIVYSVTCEQCWPESGECGPCEASVRYSEPPHGLTRTSVTVSDLEPHMNYTFTVEARNGVSGLVTSRSFRTASVSINQTEPPKVRLEGRSTTSLSVSWSIPPPQQSRVWKYEVTYRKKGDSNSYNVRRTEGFSVTLDDLAPDTTYLVQVQALTQEGQGAGSKVHEFQTLSPEGSGNLAVIGGVAVGVVLLLVLAGVGFFIHRRRKNQRARQSPEDVYFSKSEQLKPLKTYVDPHTYEDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRLPSTSGSEGVPFRTVSEWLESIKMQQYTEHFMAAGYTAIEKVVQMTNDDIKRIGVRLPGHQKRIAYSLLGLKDQVNTVGIPI","length":976,"sha256":"29416c9490a3c35fa69a9086f09fb7c75915d5d7467cb594e5b517e8fa9f344f","state":"available"},"source_refs":[{"artifact":{"bytes":6130,"format":"json","sha256":"69344b755d3085e4ba3500b2cbfe0e0673bb33b55fdcc92d8c5dcee8d660fab4","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/P29317"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"P29317","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"structure-c","target_id":"T-ENSG00000142627","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":976},"entry_name":"EPHA2_HUMAN","gene_names":"EPHA2 ECK","lipidation_sites":[],"protein_names":"Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)","raw_fields":{"lipidation":"","signal_peptide":"SIGNAL 1..23; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18794797, ECO:0000269|PubMed:19573808, ECO:0000269|PubMed:20223987, ECO:0000269|PubMed:20861311, ECO:0000269|PubMed:34067457}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, ruffle membrane {ECO:0000269|PubMed:19573808}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:19573808}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, focal adhesion {ECO:0000269|PubMed:10655584}. Note=Present at regions of cell-cell contacts but also at the leading edge of migrating cells (PubMed:19573808, PubMed:20861311). Relocates from the plasma membrane to the cytoplasmic and perinuclear regions in cancer cells (PubMed:18794797). {ECO:0000269|PubMed:18794797, ECO:0000269|PubMed:19573808, ECO:0000269|PubMed:20861311, ECO:0000269|PubMed:26158630}.","topological_domain":"TOPO_DOM 24..537; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 559..976; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 538..558; /note=\"Helical\"; /evidence=\"ECO:0000255\""},"signal_peptides":[{"description":null,"end":23,"evidence":"ECO:0000255","source_location":"SIGNAL 1..23; /evidence=\"ECO:0000255\"","start":1}],"state":"available","topological_domains":[{"description":"Extracellular","end":537,"evidence":"ECO:0000255","source_location":"TOPO_DOM 24..537; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":24},{"description":"Cytoplasmic","end":976,"evidence":"ECO:0000255","source_location":"TOPO_DOM 559..976; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":559}],"transmembrane_segments":[{"description":"Helical","end":558,"evidence":"ECO:0000255","source_location":"TRANSMEM 538..558; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":538}]},"uniprot_accession":"P29317"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000066468","evidence_rank":66,"extracellular_segments":{"records":[{"basis":"reviewed-uniprot-topological-domain","end":377,"evidence_class":"source-annotated-topology","length":356,"sequence":"RPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLE","sequence_sha256":"a81db1dfdc69b4b2527166d330ebcb53a4495aa7a18ceafd4a96a53d5b15849c","start":22}],"state":"source-annotated"},"gene_symbol":"FGFR2","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT","length":821,"sha256":"c81b4e9e806e0ace9f779e65477e6c988dea6cad5eecfbcb35f2364c5fc884dd","state":"available"},"source_refs":[{"artifact":{"bytes":49540,"format":"json","sha256":"aa399e514589c00652f52e9352b3a77bbe9619f929be9148fde6c3b16aca8c17","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/P21802"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"P21802","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"retained-unmodeled","target_id":"T-ENSG00000066468","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":821},"entry_name":"FGFR2_HUMAN","gene_names":"FGFR2 BEK KGFR KSAM","lipidation_sites":[],"protein_names":"Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332)","raw_fields":{"lipidation":"","signal_peptide":"SIGNAL 1..21; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Golgi apparatus. Cytoplasmic vesicle. Note=Detected on osteoblast plasma membrane lipid rafts. After ligand binding, the activated receptor is rapidly internalized and degraded.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Note=After ligand binding, the activated receptor is rapidly internalized and degraded.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane; Single-pass type I membrane protein. Note=After ligand binding, the activated receptor is rapidly internalized and degraded.; SUBCELLULAR LOCATION: [Isoform 8]: Secreted.; SUBCELLULAR LOCATION: [Isoform 13]: Secreted.","topological_domain":"TOPO_DOM 22..377; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 399..821; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 378..398; /note=\"Helical\"; /evidence=\"ECO:0000255\""},"signal_peptides":[{"description":null,"end":21,"evidence":"ECO:0000255","source_location":"SIGNAL 1..21; /evidence=\"ECO:0000255\"","start":1}],"state":"available","topological_domains":[{"description":"Extracellular","end":377,"evidence":"ECO:0000255","source_location":"TOPO_DOM 22..377; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":22},{"description":"Cytoplasmic","end":821,"evidence":"ECO:0000255","source_location":"TOPO_DOM 399..821; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":399}],"transmembrane_segments":[{"description":"Helical","end":398,"evidence":"ECO:0000255","source_location":"TRANSMEM 378..398; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":378}]},"uniprot_accession":"P21802"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000137845","evidence_rank":67,"extracellular_segments":{"records":[{"basis":"reviewed-uniprot-topological-domain","end":672,"evidence_class":"source-annotated-topology","length":653,"sequence":"QYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFLRLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVIDGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKAIFSPELYENIAE","sequence_sha256":"e4400d6a6307dd5802b41fdcee2791cb772b4a00d59dc139cb3f4245eb71ea3d","start":20}],"state":"source-annotated"},"gene_symbol":"ADAM10","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFLRLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVIDGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKAIFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTLKRRRPPQPIQQPQRQRPRESYQMGHMRR","length":748,"sha256":"74a4db6b2d0c653bda0ad7877139bd95207b603f7665c60adce2ef7045bb215d","state":"available"},"source_refs":[{"artifact":{"bytes":5651,"format":"json","sha256":"5c3269549a254c25b35f09b89744ddd013c20236f735c3e075708693f19644cf","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/O14672"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"O14672","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"structure-c","target_id":"T-ENSG00000137845","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":748},"entry_name":"ADA10_HUMAN","gene_names":"ADAM10 KUZ MADM","lipidation_sites":[],"protein_names":"Disintegrin and metalloproteinase domain-containing protein 10 (ADAM 10) (EC 3.4.24.81) (CDw156) (Kuzbanian protein homolog) (Mammalian disintegrin-metalloprotease) (CD antigen CD156c)","raw_fields":{"lipidation":"","signal_peptide":"SIGNAL 1..19; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20624979, ECO:0000269|PubMed:23676497, ECO:0000269|PubMed:24990881, ECO:0000269|PubMed:26686862, ECO:0000269|PubMed:29430990, ECO:0000269|PubMed:30463011, ECO:0000269|PubMed:33731436}; Single-pass type I membrane protein {ECO:0000305}. Golgi apparatus membrane {ECO:0000269|PubMed:12475894}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:12475894}. Cell projection, axon {ECO:0000250|UniProtKB:O35598}. Cell projection, dendrite {ECO:0000250|UniProtKB:O35598}. Cell junction, adherens junction {ECO:0000269|PubMed:30463011}. Cytoplasm {ECO:0000269|PubMed:30463011}. Note=Is localized in the plasma membrane but is also expressed in the Golgi apparatus and in clathrin-coated vesicles derived likely from the Golgi (PubMed:12475894). During long term depression, it is recruited to the cell membrane by DLG1 (PubMed:23676497). The immature form is mainly located near cytoplasmic fibrillar structures, while the mature form is predominantly located at zonula adherens and the cell membrane (PubMed:30463011). 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/note=\"Helical\"; /evidence=\"ECO:0000255\"","start":525}]},"uniprot_accession":"P10721"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000007062","evidence_rank":74,"extracellular_segments":{"records":[{"basis":"reviewed-uniprot-topological-domain","end":108,"evidence_class":"source-annotated-topology","length":89,"sequence":"GGQPSSTDAPKAWNYELPATNYETQDSHKAGPIGILFELVHIFLYVVQPRDFPEDTLRKFLQKAYESKIDYDKPETVILGLKIVYYEAG","sequence_sha256":"d0af8347ce3eb22f495a95018c33885c07361a147777b81652455707c2279a69","start":20},{"basis":"reviewed-uniprot-topological-domain","end":433,"evidence_class":"source-annotated-topology","length":255,"sequence":"ANHQVRTRIKRSRKLADSNFKDLRTLLNETPEQIKYILAQYNTTKDKAFTDLNSINSVLGGGILDRLRPNIIPVLDEIKSMATAIKETKEALENMNSTLKSLHQQSTQLSSSLTSVKTSLRSSLNDPLCLVHPSSETCNSIRLSLSQLNSNPELRQLPPVDAELDNVNNVLRTDLDGLVQQGYQSLNDIPDRVQRQTTTVVAGIKRVLNSIGSDIDNVTQRLPIQDILSAFSVYVNNTESYIHRNLPTLEEYDSY","sequence_sha256":"9023775f2234eb653c2c54858c427dd4d68f6d67420a061d15a35bbf477b60b3","start":179},{"basis":"reviewed-uniprot-topological-domain","end":792,"evidence_class":"source-annotated-topology","length":285,"sequence":"GANVEKLICEPYTSKELFRVLDTPYLLNEDWEYYLSGKLFNKSKMKLTFEQVYSDCKKNRGTYGTLHLQNSFNISEHLNINEHTGSISSELESLKVNLNIFLLGAAGRKNLQDFAACGIDRMNYDSYLAQTGKSPAGVNLLSFAYDLEAKANSLPPGNLRNSLKRDAQTIKTIHQQRVLPIEQSLSTLYQSVKILQRTGNGLLERVTRILASLDFAQNFITNNTSSVIIEETKKYGRTIIGYFEHYLQWIEFSISEKVASCKPVATALDTAVDVFLCSYIIDPLN","sequence_sha256":"54e40f363cbb4e5482630c10311ad1a36192124a7f0dc53cd53d7efadc650394","start":508}],"state":"source-annotated"},"gene_symbol":"PROM1","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MALVLGSLLLLGLCGNSFSGGQPSSTDAPKAWNYELPATNYETQDSHKAGPIGILFELVHIFLYVVQPRDFPEDTLRKFLQKAYESKIDYDKPETVILGLKIVYYEAGIILCCVLGLLFIILMPLVGYFFCMCRCCNKCGGEMHQRQKENGPFLRKCFAISLLVICIIISIGIFYGFVANHQVRTRIKRSRKLADSNFKDLRTLLNETPEQIKYILAQYNTTKDKAFTDLNSINSVLGGGILDRLRPNIIPVLDEIKSMATAIKETKEALENMNSTLKSLHQQSTQLSSSLTSVKTSLRSSLNDPLCLVHPSSETCNSIRLSLSQLNSNPELRQLPPVDAELDNVNNVLRTDLDGLVQQGYQSLNDIPDRVQRQTTTVVAGIKRVLNSIGSDIDNVTQRLPIQDILSAFSVYVNNTESYIHRNLPTLEEYDSYWWLGGLVICSLLTLIVIFYYLGLLCGVCGYDRHATPTTRGCVSNTGGVFLMVGVGLSFLFCWILMIIVVLTFVFGANVEKLICEPYTSKELFRVLDTPYLLNEDWEYYLSGKLFNKSKMKLTFEQVYSDCKKNRGTYGTLHLQNSFNISEHLNINEHTGSISSELESLKVNLNIFLLGAAGRKNLQDFAACGIDRMNYDSYLAQTGKSPAGVNLLSFAYDLEAKANSLPPGNLRNSLKRDAQTIKTIHQQRVLPIEQSLSTLYQSVKILQRTGNGLLERVTRILASLDFAQNFITNNTSSVIIEETKKYGRTIIGYFEHYLQWIEFSISEKVASCKPVATALDTAVDVFLCSYIIDPLNLFWFGIGKATVFLLPALIFAVKLAKYYRRMDSEDVYDDVETIPMKNMENGNNGYHKDHVYGIHNPVMTSPSQH","length":865,"sha256":"cb68350aedcd637e801a54a16f8c205c920dcde6c9f2c595bcd4a0b56251df77","state":"available"},"source_refs":[{"artifact":{"bytes":22200,"format":"json","sha256":"e4cc5c163ebb6e08d639e09dfbb40d92b477b46ef4ae4ea50b5dacb26062d6d8","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/O43490"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"O43490","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"retained-unmodeled","target_id":"T-ENSG00000007062","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":865},"entry_name":"PROM1_HUMAN","gene_names":"PROM1 PROML1 MSTP061","lipidation_sites":[],"protein_names":"Prominin-1 (Antigen AC133) (Prominin-like protein 1) (CD antigen CD133)","raw_fields":{"lipidation":"","signal_peptide":"SIGNAL 1..19; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, microvillus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250}. Endoplasmic reticulum. Endoplasmic reticulum-Golgi intermediate compartment. Note=Found in extracellular membrane particles in various body fluids such as cerebrospinal fluid, saliva, seminal fluid and urine.","topological_domain":"TOPO_DOM 20..108; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 130..157; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 179..433; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 455..486; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 508..792; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 814..865; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 109..129; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 158..178; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 434..454; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 487..507; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 793..813; /note=\"Helical\"; /evidence=\"ECO:0000255\""},"signal_peptides":[{"description":null,"end":19,"evidence":"ECO:0000255","source_location":"SIGNAL 1..19; /evidence=\"ECO:0000255\"","start":1}],"state":"available","topological_domains":[{"description":"Extracellular","end":108,"evidence":"ECO:0000255","source_location":"TOPO_DOM 20..108; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":20},{"description":"Cytoplasmic","end":157,"evidence":"ECO:0000255","source_location":"TOPO_DOM 130..157; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":130},{"description":"Extracellular","end":433,"evidence":"ECO:0000255","source_location":"TOPO_DOM 179..433; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":179},{"description":"Cytoplasmic","end":486,"evidence":"ECO:0000255","source_location":"TOPO_DOM 455..486; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":455},{"description":"Extracellular","end":792,"evidence":"ECO:0000255","source_location":"TOPO_DOM 508..792; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":508},{"description":"Cytoplasmic","end":865,"evidence":"ECO:0000255","source_location":"TOPO_DOM 814..865; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":814}],"transmembrane_segments":[{"description":"Helical","end":129,"evidence":"ECO:0000255","source_location":"TRANSMEM 109..129; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":109},{"description":"Helical","end":178,"evidence":"ECO:0000255","source_location":"TRANSMEM 158..178; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":158},{"description":"Helical","end":454,"evidence":"ECO:0000255","source_location":"TRANSMEM 434..454; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":434},{"description":"Helical","end":507,"evidence":"ECO:0000255","source_location":"TRANSMEM 487..507; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":487},{"description":"Helical","end":813,"evidence":"ECO:0000255","source_location":"TRANSMEM 793..813; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":793}]},"uniprot_accession":"O43490"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000130300","evidence_rank":75,"extracellular_segments":{"records":[{"basis":"reviewed-uniprot-topological-domain","end":442,"evidence_class":"source-annotated-topology","length":394,"sequence":"YGNVHVSTESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASFRQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTKSQPMMPVSRPMGPVPNPQPIDPASLEEFKRKILESQRPPAGIPVAPSSG","sequence_sha256":"594e16597ef952469aee7bf88448ce7d8a87e94bc245b9c0b1caa9d0254b4e0b","start":49}],"state":"source-annotated"},"gene_symbol":"PLVAP","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MGLAMEHGGSYARAGGSSRGCWYYLRYFFLFVSLIQFLIILGLVLFMVYGNVHVSTESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASFRQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTKSQPMMPVSRPMGPVPNPQPIDPASLEEFKRKILESQRPPAGIPVAPSSG","length":442,"sha256":"2647faacd277934cdb68d42958afebf6807a736c56550a20fff607d8e730055f","state":"available"},"source_refs":[{"artifact":{"bytes":2608,"format":"json","sha256":"fd7aae354b9741ec1add5f83e09989e0b32c5b5ce2e318d336537cab07a93363","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/Q9BX97"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"Q9BX97","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"retained-unmodeled","target_id":"T-ENSG00000130300","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":442},"entry_name":"PLVAP_HUMAN","gene_names":"PLVAP FELS PV1","lipidation_sites":[],"protein_names":"Plasmalemma vesicle-associated protein (Fenestrated endothelial-linked structure protein) (Plasmalemma vesicle protein 1) (PV-1)","raw_fields":{"lipidation":"","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9WV78}; Single-pass type II membrane protein {ECO:0000255}. Membrane, caveola {ECO:0000250|UniProtKB:Q9WV78}; Single-pass type II membrane protein {ECO:0000255}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9WV78}. Note=Membrane-associated protein of caveolae. Found in fenestral and stomatal diaphragms in fenestrated endothelia and transendothelial channels. 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Apical cell membrane {ECO:0000250|UniProtKB:Q00657}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q00657}; Extracellular side {ECO:0000250|UniProtKB:Q00657}. Cell projection, lamellipodium membrane {ECO:0000250|UniProtKB:Q00657}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q00657}; Extracellular side {ECO:0000250|UniProtKB:Q00657}. Cell surface {ECO:0000250|UniProtKB:Q00657}. Note=Localized at the apical plasma membrane it relocalizes to the lamellipodia of astrocytoma upon phosphorylation by PRKCA. Localizes to the retraction fibers. 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Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:19506252}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000269|PubMed:23189181}; Multi-pass membrane protein {ECO:0000255}. Note=Enriched in membrane lipid rafts. {ECO:0000269|PubMed:28623970}.","topological_domain":"TOPO_DOM 1..395; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 417..428; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 450..477; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 499..506; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 528..535; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 557..630; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 652..655; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 396..416; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 429..449; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 478..498; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 507..527; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 536..556; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 631..651; /note=\"Helical\"; /evidence=\"ECO:0000255\""},"signal_peptides":[],"state":"available","topological_domains":[{"description":"Cytoplasmic","end":395,"evidence":"ECO:0000255","source_location":"TOPO_DOM 1..395; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":1},{"description":"Extracellular","end":428,"evidence":"ECO:0000255","source_location":"TOPO_DOM 417..428; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":417},{"description":"Cytoplasmic","end":477,"evidence":"ECO:0000255","source_location":"TOPO_DOM 450..477; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":450},{"description":"Extracellular","end":506,"evidence":"ECO:0000255","source_location":"TOPO_DOM 499..506; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":499},{"description":"Cytoplasmic","end":535,"evidence":"ECO:0000255","source_location":"TOPO_DOM 528..535; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":528},{"description":"Extracellular","end":630,"evidence":"ECO:0000255","source_location":"TOPO_DOM 557..630; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":557},{"description":"Cytoplasmic","end":655,"evidence":"ECO:0000255","source_location":"TOPO_DOM 652..655; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":652}],"transmembrane_segments":[{"description":"Helical","end":416,"evidence":"ECO:0000255","source_location":"TRANSMEM 396..416; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":396},{"description":"Helical","end":449,"evidence":"ECO:0000255","source_location":"TRANSMEM 429..449; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":429},{"description":"Helical","end":498,"evidence":"ECO:0000255","source_location":"TRANSMEM 478..498; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":478},{"description":"Helical","end":527,"evidence":"ECO:0000255","source_location":"TRANSMEM 507..527; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":507},{"description":"Helical","end":556,"evidence":"ECO:0000255","source_location":"TRANSMEM 536..556; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":536},{"description":"Helical","end":651,"evidence":"ECO:0000255","source_location":"TRANSMEM 631..651; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":631}]},"uniprot_accession":"Q9UNQ0"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000146205","evidence_rank":100,"extracellular_segments":{"records":[{"basis":"reviewed-uniprot-topological-domain","end":420,"evidence_class":"source-annotated-topology","length":44,"sequence":"SDIPTQELCGSKDSFEMCPLCLDCPFWLLSSACALAQAGRLFDH","sequence_sha256":"c2bbe1cc5d74b14421c53e21cdc774ae34b94264b7aea0e6d5894d55bd8d257e","start":377},{"basis":"reviewed-uniprot-topological-domain","end":550,"evidence_class":"source-annotated-topology","length":30,"sequence":"YRAIMAIVVSRSGNTLLAAWASRIASLTGS","sequence_sha256":"3daf6a9a2fb7d82a61f132097deadfbba19bced2fa0714615cb417443d2d95b0","start":521},{"basis":"reviewed-uniprot-topological-domain","end":714,"evidence_class":"source-annotated-topology","length":105,"sequence":"KGRFVGYPGNYHTLFGVRNEECAAGGCLIELAQELLVIMVGKQVINNMQEVLIPKLKGWWQKFRLRSKKRKAGASAGASQGPWEDDYELVPCEGLFDEYLEMVLQ","sequence_sha256":"cbe2a93bb712ed105bb47b31b7b86448c13e1812f6da88538bfc0e4a2450bb3c","start":610},{"basis":"reviewed-uniprot-topological-domain","end":843,"evidence_class":"source-annotated-topology","length":59,"sequence":"AFSSDFLPRAYYRWTRAHDLRGFLNFTLARAPSSFAAAHNRTCRYRAFRDDDGHYSQTY","sequence_sha256":"80ffc1b1916f3bf46b9284400a9e81af024c7ba069190ee96a14d5356fb1e85e","start":785}],"state":"source-annotated"},"gene_symbol":"ANO7","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MRMAATAWAGLQGPPLPTLCPAVRTGLYCRDQAHAERWAMTSETSSGSHCARSRMLRRRAQEEDSTVLIDVSPPEAEKRGSYGSTAHASEPGGQQAAACRAGSPAKPRIADFVLVWEEDLKLDRQQDSAARDRTDMHRTWRETFLDNLRAAGLCVDQQDVQDGNTTVHYALLSASWAVLCYYAEDLRLKLPLQELPNQASNWSAGLLAWLGIPNVLLEVVPDVPPEYYSCRFRVNKLPRFLGSDNQDTFFTSTKRHQILFEILAKTPYGHEKKNLLGIHQLLAEGVLSAAFPLHDGPFKTPPEGPQAPRLNQRQVLFQHWARWGKWNKYQPLDHVRRYFGEKVALYFAWLGFYTGWLLPAAVVGTLVFLVGCFLVFSDIPTQELCGSKDSFEMCPLCLDCPFWLLSSACALAQAGRLFDHGGTVFFSLFMALWAVLLLEYWKRKSATLAYRWDCSDYEDTEERPRPQFAASAPMTAPNPITGEDEPYFPERSRARRMLAGSVVIVVMVAVVVMCLVSIILYRAIMAIVVSRSGNTLLAAWASRIASLTGSVVNLVFILILSKIYVSLAHVLTRWEMHRTQTKFEDAFTLKVFIFQFVNFYSSPVYIAFFKGRFVGYPGNYHTLFGVRNEECAAGGCLIELAQELLVIMVGKQVINNMQEVLIPKLKGWWQKFRLRSKKRKAGASAGASQGPWEDDYELVPCEGLFDEYLEMVLQFGFVTIFVAACPLAPLFALLNNWVEIRLDARKFVCEYRRPVAERAQDIGIWFHILAGLTHLAVISNAFLLAFSSDFLPRAYYRWTRAHDLRGFLNFTLARAPSSFAAAHNRTCRYRAFRDDDGHYSQTYWNLLAIRLAFVIVFEHVVFSVGRLLDLLVPDIPESVEIKVKREYYLAKQALAENEVLFGTNGTKDEQPEGSELSSHWTPFTVPKASQLQQ","length":933,"sha256":"e8316f260f3fa1cd475aa83846d041ba6f3541efd51176f4ddd70340d38bd074","state":"available"},"source_refs":[{"artifact":{"bytes":8592,"format":"json","sha256":"b49c4018f61ffff797bc800a4751e0ee24c3ba7eea91b69af2dbfd54d8af3257","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/Q6IWH7"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"Q6IWH7","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"retained-unmodeled","target_id":"T-ENSG00000146205","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":933},"entry_name":"ANO7_HUMAN","gene_names":"ANO7 NGEP PCANAP5 TMEM16G","lipidation_sites":[],"protein_names":"Anoctamin-7 (Dresden transmembrane protein of the prostate) (D-TMPP) (IPCA-5) (New gene expressed in prostate) (Prostate cancer-associated protein 5) (Transmembrane protein 16G)","raw_fields":{"lipidation":"","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:14981236, ECO:0000269|PubMed:17308099, ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:22946059}; Multi-pass membrane protein {ECO:0000255}. Cell junction {ECO:0000269|PubMed:17308099}. Endoplasmic reticulum {ECO:0000269|PubMed:22075693}. Note=Concentrates at sites of cell-cell contact (PubMed:17308099). Shows an intracellular localization according to PubMed:22075693 and PubMed:20056604. {ECO:0000269|PubMed:17308099, ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:22075693}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytosol {ECO:0000269|PubMed:14981236}.","topological_domain":"TOPO_DOM 1..355; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 377..420; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 442..499; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 521..550; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 572..588; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 610..714; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 736..763; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 785..843; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 865..933; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 356..376; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 421..441; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 500..520; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 551..571; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 589..609; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 715..735; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 764..784; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 844..864; /note=\"Helical\"; /evidence=\"ECO:0000255\""},"signal_peptides":[],"state":"available","topological_domains":[{"description":"Cytoplasmic","end":355,"evidence":"ECO:0000255","source_location":"TOPO_DOM 1..355; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":1},{"description":"Extracellular","end":420,"evidence":"ECO:0000255","source_location":"TOPO_DOM 377..420; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":377},{"description":"Cytoplasmic","end":499,"evidence":"ECO:0000255","source_location":"TOPO_DOM 442..499; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":442},{"description":"Extracellular","end":550,"evidence":"ECO:0000255","source_location":"TOPO_DOM 521..550; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":521},{"description":"Cytoplasmic","end":588,"evidence":"ECO:0000255","source_location":"TOPO_DOM 572..588; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":572},{"description":"Extracellular","end":714,"evidence":"ECO:0000255","source_location":"TOPO_DOM 610..714; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":610},{"description":"Cytoplasmic","end":763,"evidence":"ECO:0000255","source_location":"TOPO_DOM 736..763; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":736},{"description":"Extracellular","end":843,"evidence":"ECO:0000255","source_location":"TOPO_DOM 785..843; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":785},{"description":"Cytoplasmic","end":933,"evidence":"ECO:0000255","source_location":"TOPO_DOM 865..933; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":865}],"transmembrane_segments":[{"description":"Helical","end":376,"evidence":"ECO:0000255","source_location":"TRANSMEM 356..376; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":356},{"description":"Helical","end":441,"evidence":"ECO:0000255","source_location":"TRANSMEM 421..441; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":421},{"description":"Helical","end":520,"evidence":"ECO:0000255","source_location":"TRANSMEM 500..520; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":500},{"description":"Helical","end":571,"evidence":"ECO:0000255","source_location":"TRANSMEM 551..571; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":551},{"description":"Helical","end":609,"evidence":"ECO:0000255","source_location":"TRANSMEM 589..609; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":589},{"description":"Helical","end":735,"evidence":"ECO:0000255","source_location":"TRANSMEM 715..735; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":715},{"description":"Helical","end":784,"evidence":"ECO:0000255","source_location":"TRANSMEM 764..784; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":764},{"description":"Helical","end":864,"evidence":"ECO:0000255","source_location":"TRANSMEM 844..864; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":844}]},"uniprot_accession":"Q6IWH7"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000062038","evidence_rank":101,"extracellular_segments":{"records":[{"basis":"reviewed-uniprot-topological-domain","end":654,"evidence_class":"source-annotated-topology","length":547,"sequence":"DWVVAPISVPENGKGPFPQRLNQLKSNKDRDTKIFYSITGPGADSPPEGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSENGASVEDPMNISIIVTDQNDHKPKFTQDTFRGSVLEGVLPGTSVMQVTATDEDDAIYTYNGVVAYSIHSQEPKDPHDLMFTIHRSTGTISVISSGLDREKVPEYTLTIQATDMDGDGSTTTAVAVVEILDANDNAPMFDPQKYEAHVPENAVGHEVQRLTVTDLDAPNSPAWRATYLIMGGDDGDHFTITTHPESNQGILTTRKGLDFEAKNQHTLYVEVTNEAPFVLKLPTSTATIVVHVEDVNEAPVFVPPSKVVEVQEGIPTGEPVCVYTAEDPDKENQKISYRILRDPAGWLAMDPDSGQVTAVGTLDREDEQFVRNNIYEVMVLAMDNGSPPTTGTGTLLLTLIDVNDHGPVPEPRQITICNQSPVRQVLNITDKDLSPHTSPFQAQLTDDSDIYWTAEVNEEGDTVVLSLKKFLKQDTYDVHLSLSDHGNKEQLTVIRATVCDCHGHVETCPGPWKGG","sequence_sha256":"3bf878ac541e9c632a2fb477479c7ea1bb92cab5d89777e9533f45d0496d1361","start":108}],"state":"source-annotated"},"gene_symbol":"CDH3","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MGLPRGPLASLLLLQVCWLQCAASEPCRAVFREAEVTLEAGGAEQEPGQALGKVFMGCPGQEPALFSTDNDDFTVRNGETVQERRSLKERNPLKIFPSKRILRRHKRDWVVAPISVPENGKGPFPQRLNQLKSNKDRDTKIFYSITGPGADSPPEGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSENGASVEDPMNISIIVTDQNDHKPKFTQDTFRGSVLEGVLPGTSVMQVTATDEDDAIYTYNGVVAYSIHSQEPKDPHDLMFTIHRSTGTISVISSGLDREKVPEYTLTIQATDMDGDGSTTTAVAVVEILDANDNAPMFDPQKYEAHVPENAVGHEVQRLTVTDLDAPNSPAWRATYLIMGGDDGDHFTITTHPESNQGILTTRKGLDFEAKNQHTLYVEVTNEAPFVLKLPTSTATIVVHVEDVNEAPVFVPPSKVVEVQEGIPTGEPVCVYTAEDPDKENQKISYRILRDPAGWLAMDPDSGQVTAVGTLDREDEQFVRNNIYEVMVLAMDNGSPPTTGTGTLLLTLIDVNDHGPVPEPRQITICNQSPVRQVLNITDKDLSPHTSPFQAQLTDDSDIYWTAEVNEEGDTVVLSLKKFLKQDTYDVHLSLSDHGNKEQLTVIRATVCDCHGHVETCPGPWKGGFILPVLGAVLALLFLLLVLLLLVRKKRKIKEPLLLPEDDTRDNVFYYGEEGGGEEDQDYDITQLHRGLEARPEVVLRNDVAPTIIPTPMYRPRPANPDEIGNFIIENLKAANTDPTAPPYDTLLVFDYEGSGSDAASLSSLTSSASDQDQDYDYLNEWGSRFKKLADMYGGGEDD","length":829,"sha256":"2469935445ed65fca853e5f1237c7280a339fe2cc5d90f6b0f1ca319d21dff48","state":"available"},"source_refs":[{"artifact":{"bytes":6374,"format":"json","sha256":"40b9f4fa3f01a10557612e583bae27ed24c63f63a7e067c906129831ec58a675","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/P22223"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"P22223","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"retained-unmodeled","target_id":"T-ENSG00000062038","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":829},"entry_name":"CADH3_HUMAN","gene_names":"CDH3 CDHP","lipidation_sites":[],"protein_names":"Cadherin-3 (Placental cadherin) (P-cadherin)","raw_fields":{"lipidation":"","signal_peptide":"SIGNAL 1..24; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.","topological_domain":"TOPO_DOM 108..654; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 678..829; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 655..677; /note=\"Helical\"; /evidence=\"ECO:0000255\""},"signal_peptides":[{"description":null,"end":24,"evidence":"ECO:0000255","source_location":"SIGNAL 1..24; /evidence=\"ECO:0000255\"","start":1}],"state":"available","topological_domains":[{"description":"Extracellular","end":654,"evidence":"ECO:0000255","source_location":"TOPO_DOM 108..654; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":108},{"description":"Cytoplasmic","end":829,"evidence":"ECO:0000255","source_location":"TOPO_DOM 678..829; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":678}],"transmembrane_segments":[{"description":"Helical","end":677,"evidence":"ECO:0000255","source_location":"TRANSMEM 655..677; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":655}]},"uniprot_accession":"P22223"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000066405","evidence_rank":102,"extracellular_segments":{"records":[{"basis":"reviewed-uniprot-topological-domain","end":80,"evidence_class":"source-annotated-topology","length":53,"sequence":"DMWSTQDLYDNPVTSVFQYEGLWRSCVRQSSGFTECRPYFTILGLPAMLQAVR","sequence_sha256":"2cfa4c45314f72356b167e6363926e4d023594dce5b50b583851a12d379aa8f6","start":28},{"basis":"reviewed-uniprot-topological-domain","end":174,"evidence_class":"source-annotated-topology","length":31,"sequence":"VTNFWMSTANMYTGMGGMVQTVQTRYTFGAA","sequence_sha256":"f232105a166d351c3055d9d9ed6ef1b704984bb4001cdea111c93097b02f7c92","start":144}],"state":"source-annotated"},"gene_symbol":"CLDN18","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MSTTTCQVVAFLLSILGLAGCIAATGMDMWSTQDLYDNPVTSVFQYEGLWRSCVRQSSGFTECRPYFTILGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKIYDGGARTEDEVQSYPSKHDYV","length":261,"sha256":"89c388e151022937dd56f7be9599e2f03f07e579e7c1308d4112f0c386b1491c","state":"available"},"source_refs":[{"artifact":{"bytes":4197,"format":"json","sha256":"fb8a96b9e46008b665ddb1166aaf45314aeb847df7bfc131dfd0a27aab4b8df4","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/P56856"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"P56856","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"structure-c","target_id":"T-ENSG00000066405","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":261},"entry_name":"CLD18_HUMAN","gene_names":"CLDN18 UNQ778/PRO1572","lipidation_sites":[],"protein_names":"Claudin-18","raw_fields":{"lipidation":"","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000250|UniProtKB:P56857}. Cell membrane {ECO:0000250|UniProtKB:P56857}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to tight junctions in epithelial cells. {ECO:0000250|UniProtKB:P56857}.; SUBCELLULAR LOCATION: [Isoform A1]: Cell junction, tight junction {ECO:0000250|UniProtKB:P56857}.; SUBCELLULAR LOCATION: [Isoform A2]: Cell junction, tight junction {ECO:0000250|UniProtKB:P56857}. 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Its interaction with CAV1 is necessary for its translocation to membrane rafts (PubMed:17287217). Colocalized with PTPRC in membrane rafts (PubMed:12676959). Colocalized with FAP in invadopodia and lamellipodia of migratory activated endothelial cells in collagenous matrix. Colocalized with FAP on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma (PubMed:16651416). Colocalized with ADA at the cell junction in lymphocyte-epithelial cell adhesion (PubMed:11772392). Colocalized with IGF2R in internalized cytoplasmic vesicles adjacent to the cell surface (PubMed:10900005). {ECO:0000269|PubMed:10900005, ECO:0000269|PubMed:11772392, ECO:0000269|PubMed:11773049, ECO:0000269|PubMed:12676959, ECO:0000269|PubMed:16651416, ECO:0000269|PubMed:17287217}.","topological_domain":"TOPO_DOM 1..6; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 29..766; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 7..28; /note=\"Helical; Signal-anchor for type II membrane protein\"; /evidence=\"ECO:0000255\""},"signal_peptides":[],"state":"available","topological_domains":[{"description":"Cytoplasmic","end":6,"evidence":"ECO:0000255","source_location":"TOPO_DOM 1..6; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":1},{"description":"Extracellular","end":766,"evidence":"ECO:0000255","source_location":"TOPO_DOM 29..766; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":29}],"transmembrane_segments":[{"description":"Helical; Signal-anchor for type II membrane protein","end":28,"evidence":"ECO:0000255","source_location":"TRANSMEM 7..28; /note=\"Helical; Signal-anchor for type II membrane protein\"; /evidence=\"ECO:0000255\"","start":7}]},"uniprot_accession":"P27487"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000171124","evidence_rank":104,"extracellular_segments":{"records":[],"state":"not-explicitly-annotated"},"gene_symbol":"FUT3","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MDPLGAAKPQWPWRRCLAALLFQLLVAVCFFSYLRVSRDDATGSPRAPSGSSRQDTTPTRPTLLILLRTWPFHIPVALSRCSEMVPGTADCHITADRKVYPQADMVIVHHWDIMSNPKSRLPPSPRPQGQRWIWFNLEPPPNCQHLEALDRYFNLTMSYRSDSDIFTPYGWLEPWSGQPAHPPLNLSAKTELVAWAVSNWKPDSARVRYYQSLQAHLKVDVYGRSHKPLPKGTMMETLSRYKFYLAFENSLHPDYITEKLWRNALEAWAVPVVLGPSRSNYERFLPPDAFIHVDDFQSPKDLARYLQELDKDHARYLSYFRWRETLRPRSFSWALDFCKACWKLQQESRYQTVRSIAAWFT","length":361,"sha256":"b61c11011f05f674924fd36208448ef5cb1b06449508241cff49916b813ecf0b","state":"available"},"source_refs":[{"artifact":{"bytes":2473,"format":"json","sha256":"58e92cac1f04f358b6996e3a213fcbb5c7e14cd38e257a4394d3a5d13f1e7fe7","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/P21217"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"P21217","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"retained-unmodeled","target_id":"T-ENSG00000171124","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":361},"entry_name":"FUT3_HUMAN","gene_names":"FUT3 FT3B LE","lipidation_sites":[],"protein_names":"3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3 (EC 2.4.1.65) (4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase) (EC 2.4.1.152) (Alpha-3-fucosyltransferase FUT3) (EC 2.4.1.-) (Blood group Lewis alpha-4-fucosyltransferase) (Lewis FT) (Fucosyltransferase 3) (Fucosyltransferase III) (FucT-III)","raw_fields":{"lipidation":"","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein {ECO:0000269|PubMed:1977660}. 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/evidence=\"ECO:0000255\"; TRANSMEM 683..703; /note=\"Helical; Name=4\"; /evidence=\"ECO:0000255\"; TRANSMEM 723..743; /note=\"Helical; Name=5\"; /evidence=\"ECO:0000255\"; TRANSMEM 768..788; /note=\"Helical; Name=6\"; /evidence=\"ECO:0000255\"; TRANSMEM 803..823; /note=\"Helical; Name=7\"; /evidence=\"ECO:0000255\""},"signal_peptides":[{"description":null,"end":21,"evidence":"ECO:0000255","source_location":"SIGNAL 1..21; /evidence=\"ECO:0000255\"","start":1}],"state":"available","topological_domains":[{"description":"Extracellular","end":561,"evidence":"ECO:0000255","source_location":"TOPO_DOM 22..561; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":22},{"description":"Cytoplasmic","end":593,"evidence":"ECO:0000255","source_location":"TOPO_DOM 583..593; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":583},{"description":"Extracellular","end":638,"evidence":"ECO:0000255","source_location":"TOPO_DOM 615..638; /note=\"Extracellular\"; 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/note=\"Helical; Name=1\"; /evidence=\"ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425\"","start":37},{"description":"Helical; Name=2","end":96,"evidence":"ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425","source_location":"TRANSMEM 74..96; /note=\"Helical; Name=2\"; /evidence=\"ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425\"","start":74},{"description":"Helical; Name=3","end":133,"evidence":"ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425","source_location":"TRANSMEM 111..133; /note=\"Helical; Name=3\"; /evidence=\"ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425\"","start":111},{"description":"Helical; Name=4","end":173,"evidence":"ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425","source_location":"TRANSMEM 153..173; /note=\"Helical; Name=4\"; /evidence=\"ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425\"","start":153},{"description":"Helical; Name=5","end":224,"evidence":"ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425","source_location":"TRANSMEM 203..224; /note=\"Helical; Name=5\"; /evidence=\"ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425\"","start":203},{"description":"Helical; Name=6","end":274,"evidence":"ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425","source_location":"TRANSMEM 253..274; /note=\"Helical; Name=6\"; /evidence=\"ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425\"","start":253},{"description":"Helical; Name=7","end":309,"evidence":"ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425","source_location":"TRANSMEM 285..309; /note=\"Helical; Name=7\"; /evidence=\"ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425\"","start":285}]},"uniprot_accession":"P08100"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000106991","evidence_rank":146,"extracellular_segments":{"records":[{"basis":"reviewed-uniprot-topological-domain","end":586,"evidence_class":"source-annotated-topology","length":561,"sequence":"ETVHCDLQPVGPERGEVTYTTSQVSKGCVAQAPNAILEVHVLFLEFPTGPSQLELTLQASKQNGTWPREVLLVLSVNSSVFLHLQALGIPLHLAYNSSLVTFQEPPGVNTTELPSFPKTQILEWAAERGPITSAAELNDPQSILLRLGQAQGSLSFCMLEASQDMGRTLEWRPRTPALVRGCHLEGVAGHKEAHILRVLPGHSAGPRTVTVKVELSCAPGDLDAVLILQGPPYVSWLIDANHNMQIWTTGEYSFKIFPEKNIRGFKLPDTPQGLLGEARMLNASIVASFVELPLASIVSLHASSCGGRLQTSPAPIQTTPPKDTCSPELLMSLIQTKCADDAMTLVLKKELVAHLKCTITGLTFWDPSCEAEDRGDKFVLRSAYSSCGMQVSASMISNEAVVNILSSSSPQRKKVHCLNMDSLSFQLGLYLSPHFLQASNTIEPGQQSFVQVRVSPSVSEFLLQLDSCHLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGDPRFSFLLHFYTVPIPKTGTLSCTVALRPKTGSQDQEVHRTVFMRLNIISPDLSGCTSKG","sequence_sha256":"4e26520ec188e0b55ce5e09e8cc77b5551ec3fc672b8f8e5ac55e78484b0cda1","start":26}],"state":"source-annotated"},"gene_symbol":"ENG","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MDRGTLPLAVALLLASCSLSPTSLAETVHCDLQPVGPERGEVTYTTSQVSKGCVAQAPNAILEVHVLFLEFPTGPSQLELTLQASKQNGTWPREVLLVLSVNSSVFLHLQALGIPLHLAYNSSLVTFQEPPGVNTTELPSFPKTQILEWAAERGPITSAAELNDPQSILLRLGQAQGSLSFCMLEASQDMGRTLEWRPRTPALVRGCHLEGVAGHKEAHILRVLPGHSAGPRTVTVKVELSCAPGDLDAVLILQGPPYVSWLIDANHNMQIWTTGEYSFKIFPEKNIRGFKLPDTPQGLLGEARMLNASIVASFVELPLASIVSLHASSCGGRLQTSPAPIQTTPPKDTCSPELLMSLIQTKCADDAMTLVLKKELVAHLKCTITGLTFWDPSCEAEDRGDKFVLRSAYSSCGMQVSASMISNEAVVNILSSSSPQRKKVHCLNMDSLSFQLGLYLSPHFLQASNTIEPGQQSFVQVRVSPSVSEFLLQLDSCHLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGDPRFSFLLHFYTVPIPKTGTLSCTVALRPKTGSQDQEVHRTVFMRLNIISPDLSGCTSKGLVLPAVLGITFGAFLIGALLTAALWYIYSHTRSPSKREPVVAVAAPASSESSSTNHSIGSTQSTPCSTSSMA","length":658,"sha256":"9d83bcc4b07c00cde894c5077339d6e62f4ef394c3339ce76380957cc320da13","state":"available"},"source_refs":[{"artifact":{"bytes":5707,"format":"json","sha256":"4ec03924dd47a99e3f82fc6be020b14239d385621b38e66b1b9c03e3470537ab","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/P17813"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"P17813","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"structure-c","target_id":"T-ENSG00000106991","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":658},"entry_name":"EGLN_HUMAN","gene_names":"ENG END","lipidation_sites":[],"protein_names":"Endoglin (CD antigen CD105)","raw_fields":{"lipidation":"","signal_peptide":"SIGNAL 1..25; /evidence=\"ECO:0000269|PubMed:1692830\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10545596, ECO:0000269|PubMed:1326540, ECO:0000269|PubMed:1692830, ECO:0000269|PubMed:17540773, ECO:0000269|PubMed:8370410}; Single-pass type I membrane protein {ECO:0000305|PubMed:1692830, ECO:0000305|PubMed:8370410}.","topological_domain":"TOPO_DOM 26..586; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 612..658; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 587..611; /note=\"Helical\"; /evidence=\"ECO:0000255\""},"signal_peptides":[{"description":null,"end":25,"evidence":"ECO:0000269|PubMed:1692830","source_location":"SIGNAL 1..25; /evidence=\"ECO:0000269|PubMed:1692830\"","start":1}],"state":"available","topological_domains":[{"description":"Extracellular","end":586,"evidence":"ECO:0000255","source_location":"TOPO_DOM 26..586; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":26},{"description":"Cytoplasmic","end":658,"evidence":"ECO:0000255","source_location":"TOPO_DOM 612..658; 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/evidence=\"ECO:0000269|PubMed:15340161\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.","topological_domain":"TOPO_DOM 27..529; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 551..685; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 530..550; /note=\"Helical\"; /evidence=\"ECO:0000255\""},"signal_peptides":[{"description":null,"end":26,"evidence":"ECO:0000269|PubMed:15340161","source_location":"SIGNAL 1..26; /evidence=\"ECO:0000269|PubMed:15340161\"","start":1}],"state":"available","topological_domains":[{"description":"Extracellular","end":529,"evidence":"ECO:0000255","source_location":"TOPO_DOM 27..529; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":27},{"description":"Cytoplasmic","end":685,"evidence":"ECO:0000255","source_location":"TOPO_DOM 551..685; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":551}],"transmembrane_segments":[{"description":"Helical","end":550,"evidence":"ECO:0000255","source_location":"TRANSMEM 530..550; 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Cell junction {ECO:0000269|PubMed:20837484}. Note=Colocalizes with MMP14 at cell junctions. Also localizes at the leading edge of migrating cells. {ECO:0000269|PubMed:20837484}.","topological_domain":"TOPO_DOM 31..704; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 726..1070; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 705..725; /note=\"Helical\"; /evidence=\"ECO:0000255\""},"signal_peptides":[{"description":null,"end":30,"evidence":"ECO:0000255","source_location":"SIGNAL 1..30; /evidence=\"ECO:0000255\"","start":1}],"state":"available","topological_domains":[{"description":"Extracellular","end":704,"evidence":"ECO:0000255","source_location":"TOPO_DOM 31..704; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":31},{"description":"Cytoplasmic","end":1070,"evidence":"ECO:0000255","source_location":"TOPO_DOM 726..1070; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":726}],"transmembrane_segments":[{"description":"Helical","end":725,"evidence":"ECO:0000255","source_location":"TRANSMEM 705..725; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":705}]},"uniprot_accession":"Q13308"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000169604","evidence_rank":149,"extracellular_segments":{"records":[{"basis":"reviewed-uniprot-topological-domain","end":321,"evidence_class":"source-annotated-topology","length":289,"sequence":"EDGGPACYGGFDLYFILDKSGSVLHHWNEIYYFVEQLAHKFISPQLRMSFIVFSTRGTTLMKLTEDREQIRQGLEELQKVLPGGDTYMHEGFERASEQIYYENRQGYRTASVIIALTDGELHEDLFFYSEREANRSRDLGAIVYCVGVKDFNETQLARIADSKDHVFPVNDGFQALQGIIHSILKKSCIEILAAEPSTICAGESFQVVVRGNGFRHARNVDRVLCSFKINDSVTLNEKPFSVEDTYLLCPAPILKEVGMKAALQVSMNDGLSFISSSVIITTTHCSDGS","sequence_sha256":"3cb9e92a8ef9e54e7bb21666e64c1456f8697a6ae306ea54f8f0b0d8400c16e1","start":33}],"state":"source-annotated"},"gene_symbol":"ANTXR1","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MATAERRALGIGFQWLSLATLVLICAGQGGRREDGGPACYGGFDLYFILDKSGSVLHHWNEIYYFVEQLAHKFISPQLRMSFIVFSTRGTTLMKLTEDREQIRQGLEELQKVLPGGDTYMHEGFERASEQIYYENRQGYRTASVIIALTDGELHEDLFFYSEREANRSRDLGAIVYCVGVKDFNETQLARIADSKDHVFPVNDGFQALQGIIHSILKKSCIEILAAEPSTICAGESFQVVVRGNGFRHARNVDRVLCSFKINDSVTLNEKPFSVEDTYLLCPAPILKEVGMKAALQVSMNDGLSFISSSVIITTTHCSDGSILAIALLILFLLLALALLWWFWPLCCTVIIKEVPPPPAEESEEEDDDGLPKKKWPTVDASYYGGRGVGGIKRMEVRWGEKGSTEEGAKLEKAKNARVKMPEQEYEFPEPRNLNNNMRRPSSPRKWYSPIKGKLDALWVLLRKGYDRVSVMRPQPGDTGRCINFTRVKNNQPAKYPLNNAYHTSSPPPAPIYTPPPPAPHCPPPPPSAPTPPIPSPPSTLPPPPQAPPPNRAPPPSRPPPRPSV","length":564,"sha256":"cd36e0becd7cef67ed39ad1f6b614146a90737cff00d7fae025827a63b65e2ed","state":"available"},"source_refs":[{"artifact":{"bytes":13969,"format":"json","sha256":"2be54313bad02d11efc4af9e0f4748a08e6ad8307456e47a8b5464aae9a04d7d","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/Q9H6X2"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"Q9H6X2","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"structure-c","target_id":"T-ENSG00000169604","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":564},"entry_name":"ANTR1_HUMAN","gene_names":"ANTXR1 ATR TEM8","lipidation_sites":[],"protein_names":"Anthrax toxin receptor 1 (Tumor endothelial marker 8)","raw_fields":{"lipidation":"","signal_peptide":"SIGNAL 1..32; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16762926, ECO:0000269|PubMed:30241478}; Single-pass type I membrane protein {ECO:0000269|PubMed:16762926}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:16762926}; Single-pass type I membrane protein {ECO:0000269|PubMed:16762926}. Cell projection, filopodium membrane {ECO:0000269|PubMed:16762926}; Single-pass type I membrane protein {ECO:0000269|PubMed:16762926}. Note=At the membrane of lamellipodia and at the tip of actin-enriched filopodia (PubMed:16762926). Colocalizes with actin at the base of lamellipodia (PubMed:16762926). {ECO:0000269|PubMed:16762926}.","topological_domain":"TOPO_DOM 33..321; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 343..564; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 322..342; /note=\"Helical\"; /evidence=\"ECO:0000255\""},"signal_peptides":[{"description":null,"end":32,"evidence":"ECO:0000255","source_location":"SIGNAL 1..32; /evidence=\"ECO:0000255\"","start":1}],"state":"available","topological_domains":[{"description":"Extracellular","end":321,"evidence":"ECO:0000255","source_location":"TOPO_DOM 33..321; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":33},{"description":"Cytoplasmic","end":564,"evidence":"ECO:0000255","source_location":"TOPO_DOM 343..564; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":343}],"transmembrane_segments":[{"description":"Helical","end":342,"evidence":"ECO:0000255","source_location":"TRANSMEM 322..342; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":322}]},"uniprot_accession":"Q9H6X2"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000078098","evidence_rank":150,"extracellular_segments":{"records":[{"basis":"reviewed-uniprot-topological-domain","end":760,"evidence_class":"source-annotated-topology","length":735,"sequence":"LRPSRVHNSEENTMRALTLKDILNGTFSYKTFFPNWISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGDEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVGPQEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHIEESRTGWAGGFFVSTPVFSYDAISYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRVTQDSLFYSSNEFEEYPGRRNIYRISIGSYPPSKKCVTCHLRKERCQYYTASFSDYAKYYALVCYGPGIPISTLHDGRTDQEIKILEENKELENALKNIQLPKEEIKKLEVDEITLWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVYTERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTHFLKQCFSLSD","sequence_sha256":"8a73e2ecfae3560153da161736dc9f14bd86bbfa1301bf3bb006ea38a2e844ac","start":26}],"state":"source-annotated"},"gene_symbol":"FAP","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MKTWVKIVFGVATSAVLALLVMCIVLRPSRVHNSEENTMRALTLKDILNGTFSYKTFFPNWISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGDEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVGPQEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHIEESRTGWAGGFFVSTPVFSYDAISYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRVTQDSLFYSSNEFEEYPGRRNIYRISIGSYPPSKKCVTCHLRKERCQYYTASFSDYAKYYALVCYGPGIPISTLHDGRTDQEIKILEENKELENALKNIQLPKEEIKKLEVDEITLWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVYTERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTHFLKQCFSLSD","length":760,"sha256":"fc502b7363283bca3ea0e276ed1d65d0ae8d5064519a226a06f9c77059235b6f","state":"available"},"source_refs":[{"artifact":{"bytes":5169,"format":"json","sha256":"ddcb0dcadbf42524358f1646b38e750c309cd7eb7943aa2fd3ccd90159a181e1","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/Q12884"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"Q12884","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"structure-a","target_id":"T-ENSG00000078098","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":760},"entry_name":"SEPR_HUMAN","gene_names":"FAP","lipidation_sites":[],"protein_names":"Prolyl endopeptidase FAP (EC 3.4.21.26) (170 kDa melanoma membrane-bound gelatinase) (Dipeptidyl peptidase FAP) (EC 3.4.14.5) (Fibroblast activation protein alpha) (FAPalpha) (Gelatine degradation protease FAP) (EC 3.4.21.-) (Integral membrane serine protease) (Post-proline cleaving enzyme) (Serine integral membrane protease) (SIMP) (Surface-expressed protease) (Seprase) [Cleaved into: Antiplasmin-cleaving enzyme FAP, soluble form (APCE) (EC 3.4.14.5) (EC 3.4.21.-) (EC 3.4.21.26)]","raw_fields":{"lipidation":"","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: [Prolyl endopeptidase FAP]: Cell surface {ECO:0000269|PubMed:10593948, ECO:0000269|PubMed:16175601, ECO:0000269|PubMed:17105646, ECO:0000269|PubMed:24717288, ECO:0000269|PubMed:7911242}. Cell membrane {ECO:0000269|PubMed:12376466, ECO:0000269|PubMed:16651416, ECO:0000269|PubMed:9065413, ECO:0000303|PubMed:10455171}; Single-pass type II membrane protein {ECO:0000255}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:16651416, ECO:0000269|PubMed:9065413}; Single-pass type II membrane protein {ECO:0000255}. Cell projection, invadopodium membrane {ECO:0000269|PubMed:12376466, ECO:0000269|PubMed:16651416, ECO:0000269|PubMed:7923219, ECO:0000269|PubMed:9065413, ECO:0000303|PubMed:10455171}; Single-pass type II membrane protein {ECO:0000255}. Cell projection, ruffle membrane {ECO:0000303|PubMed:10455171}; Single-pass type II membrane protein {ECO:0000255}. Membrane {ECO:0000269|PubMed:2172980}; Single-pass type II membrane protein {ECO:0000255}. Note=Localized on cell surface with lamellipodia and invadopodia membranes and on shed vesicles. Colocalized with DPP4 at invadopodia and lamellipodia membranes of migratory activated endothelial cells in collagenous matrix. Colocalized with DPP4 on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma. Anchored and enriched preferentially by integrin alpha-3/beta-1 at invadopodia, plasma membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner. Localized at plasma and ruffle membranes in a collagen-independent manner. Colocalized with PLAUR preferentially at the cell surface of invadopodia membranes in a cytoskeleton-, integrin- and vitronectin-dependent manner. Concentrated at invadopodia membranes, specialized protrusions of the ventral plasma membrane in a fibrobectin-dependent manner. Colocalizes with extracellular components (ECM), such as collagen fibers and fibronectin. {ECO:0000269|PubMed:10593948, ECO:0000269|PubMed:12376466, ECO:0000269|PubMed:16175601, ECO:0000269|PubMed:16651416, ECO:0000269|PubMed:17105646, ECO:0000269|PubMed:2172980, ECO:0000269|PubMed:24717288, ECO:0000269|PubMed:7911242, ECO:0000269|PubMed:7923219, ECO:0000269|PubMed:9065413, ECO:0000303|PubMed:10455171}.; SUBCELLULAR LOCATION: [Antiplasmin-cleaving enzyme FAP, soluble form]: Secreted {ECO:0000269|PubMed:14751930, ECO:0000269|PubMed:16223769, ECO:0000269|PubMed:24371721}. Note=Found in blood plasma and serum. {ECO:0000269|PubMed:14751930, ECO:0000269|PubMed:16223769, ECO:0000269|PubMed:24371721}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000303|PubMed:10644713}.","topological_domain":"TOPO_DOM 1..4; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255, ECO:0000303|PubMed:14751930\"; TOPO_DOM 26..760; /note=\"Extracellular\"; /evidence=\"ECO:0000255, ECO:0000303|PubMed:14751930\"","transmembrane":"TRANSMEM 5..25; /note=\"Helical; Signal-anchor for type II membrane protein\"; /evidence=\"ECO:0000255\""},"signal_peptides":[],"state":"available","topological_domains":[{"description":"Cytoplasmic","end":4,"evidence":"ECO:0000255, ECO:0000303|PubMed:14751930","source_location":"TOPO_DOM 1..4; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255, ECO:0000303|PubMed:14751930\"","start":1},{"description":"Extracellular","end":760,"evidence":"ECO:0000255, ECO:0000303|PubMed:14751930","source_location":"TOPO_DOM 26..760; /note=\"Extracellular\"; /evidence=\"ECO:0000255, ECO:0000303|PubMed:14751930\"","start":26}],"transmembrane_segments":[{"description":"Helical; Signal-anchor for type II membrane protein","end":25,"evidence":"ECO:0000255","source_location":"TRANSMEM 5..25; /note=\"Helical; Signal-anchor for type II membrane protein\"; /evidence=\"ECO:0000255\"","start":5}]},"uniprot_accession":"Q12884"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000091972","evidence_rank":151,"extracellular_segments":{"records":[{"basis":"reviewed-uniprot-topological-domain","end":232,"evidence_class":"source-annotated-topology","length":202,"sequence":"QVQVVTQDEREQLYTPASLKCSLQNAQEALIVTWQKKKAVSPENMVTFSENHGVVIQPAYKDKINITQLGLQNSTITFWNITLEDEGCYMCLFNTFGFGKISGTACLTVYVQPIVSLHYKFSEDHLNITCSATARPAPMVFWKVPRSGIENSTVTLSHPNGTTSVTSILHIKDPKNQVGKEVICQVLHLGTVTDFKQTVNKG","sequence_sha256":"d0b8277597db4f2521f3e66daafc6c15ece2c66a1ed3cb0fc6ca67873e02b753","start":31}],"state":"source-annotated"},"gene_symbol":"CD200","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MERLVIRMPFSHLSTYSLVWVMAAVVLCTAQVQVVTQDEREQLYTPASLKCSLQNAQEALIVTWQKKKAVSPENMVTFSENHGVVIQPAYKDKINITQLGLQNSTITFWNITLEDEGCYMCLFNTFGFGKISGTACLTVYVQPIVSLHYKFSEDHLNITCSATARPAPMVFWKVPRSGIENSTVTLSHPNGTTSVTSILHIKDPKNQVGKEVICQVLHLGTVTDFKQTVNKGYWFSVPLLLSIVSLVILLVLISILLYWKRHRNQDRGELSQGVQKMT","length":278,"sha256":"0bb64c2c264604736cb55682994d6fc7658581911a587b755f518dc673c57a98","state":"available"},"source_refs":[{"artifact":{"bytes":6088,"format":"json","sha256":"3be3c01d01a2a62733ae522bb3a638b2f9b09c1773c8eea1c39aa7b01fb67b3e","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/P41217"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"P41217","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"retained-unmodeled","target_id":"T-ENSG00000091972","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":278},"entry_name":"OX2G_HUMAN","gene_names":"CD200 MOX1 MOX2 My033","lipidation_sites":[],"protein_names":"OX-2 membrane glycoprotein (CD antigen CD200)","raw_fields":{"lipidation":"","signal_peptide":"SIGNAL 1..30; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.","topological_domain":"TOPO_DOM 31..232; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 260..278; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 233..259; /note=\"Helical\"; /evidence=\"ECO:0000255\""},"signal_peptides":[{"description":null,"end":30,"evidence":"ECO:0000255","source_location":"SIGNAL 1..30; /evidence=\"ECO:0000255\"","start":1}],"state":"available","topological_domains":[{"description":"Extracellular","end":232,"evidence":"ECO:0000255","source_location":"TOPO_DOM 31..232; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":31},{"description":"Cytoplasmic","end":278,"evidence":"ECO:0000255","source_location":"TOPO_DOM 260..278; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":260}],"transmembrane_segments":[{"description":"Helical","end":259,"evidence":"ECO:0000255","source_location":"TRANSMEM 233..259; 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Associated with the plasma membrane when palmitoylated.","topological_domain":"","transmembrane":""},"signal_peptides":[],"state":"available","topological_domains":[],"transmembrane_segments":[]},"uniprot_accession":"P03372"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000168036","evidence_rank":156,"extracellular_segments":{"records":[],"state":"not-explicitly-annotated"},"gene_symbol":"CTNNB1","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL","length":781,"sha256":"1e713d035af00ae7ec7e42f80259ed46e06120d2d5c617d320c91de02ce4dd1d","state":"available"},"source_refs":[{"artifact":{"bytes":3261,"format":"json","sha256":"7174ae19131ceb530b2ac1b80575de0d1718daa51fb8ebea66f0a0455cba2eda","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/P35222"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"P35222","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"retained-unmodeled","target_id":"T-ENSG00000168036","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":781},"entry_name":"CTNB1_HUMAN","gene_names":"CTNNB1 CTNNB OK/SW-cl.35 PRO2286","lipidation_sites":[],"protein_names":"Catenin beta-1 (Beta-catenin)","raw_fields":{"lipidation":"","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22294297, ECO:0000269|PubMed:25183871, ECO:0000269|PubMed:29739711, ECO:0000269|PubMed:29910125, ECO:0000269|PubMed:31801859}. Nucleus {ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:24342833, ECO:0000269|PubMed:25183871, ECO:0000269|PubMed:28829046, ECO:0000269|PubMed:29367600, ECO:0000269|PubMed:29739711, ECO:0000269|PubMed:29910125, ECO:0000269|PubMed:30714168, ECO:0000269|PubMed:31801859}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:B6V8E6}. Cell junction, adherens junction {ECO:0000269|PubMed:10725230, ECO:0000269|PubMed:22294297}. Cell junction {ECO:0000250|UniProtKB:B6V8E6}. Cell membrane {ECO:0000269|PubMed:11790773, ECO:0000269|PubMed:24342833}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Synapse {ECO:0000250|UniProtKB:Q02248}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q02248}. Note=Colocalized with RAPGEF2 and TJP1 at cell-cell contacts (By similarity). Cytoplasmic when it is un-stable (highly phosphorylated) or bound to CDH1. Translocates to the nucleus when it is stabilized (low level of phosphorylation). Interaction with GLIS2 and MUC1 promotes nuclear translocation. Interaction with EMD inhibits nuclear localization. The majority of CTNNB1 is localized to the cell membrane. In interphase, colocalizes with CROCC between CEP250 puncta at the proximal end of centrioles, and this localization is dependent on CROCC and CEP250. In mitosis, when NEK2 activity increases, it localizes to centrosomes at spindle poles independent of CROCC. Colocalizes with CDK5 in the cell-cell contacts and plasma membrane of undifferentiated and differentiated neuroblastoma cells. Interaction with FAM53B promotes translocation to the nucleus (PubMed:25183871). Translocates to the nucleus in the presence of SNAIL1 (By similarity). Ca(2+)-mediated localization to the cell membrane in dental epithelial cells is inhibited via WNT3A (By similarity). Localizes to cell-cell contacts as keratinocyte differentiation progresses (By similarity). {ECO:0000250|UniProtKB:B6V8E6, ECO:0000250|UniProtKB:Q02248, ECO:0000269|PubMed:25183871}.","topological_domain":"","transmembrane":""},"signal_peptides":[],"state":"available","topological_domains":[],"transmembrane_segments":[]},"uniprot_accession":"P35222"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000157765","evidence_rank":157,"extracellular_segments":{"records":[{"basis":"reviewed-uniprot-topological-domain","end":135,"evidence_class":"source-annotated-topology","length":14,"sequence":"FQLVGGKMAGQFFS","sequence_sha256":"ad2b2d50fc80017ad71946812d9f32419570087c74ddcb173b5253f6befa78b0","start":122},{"basis":"reviewed-uniprot-topological-domain","end":362,"evidence_class":"source-annotated-topology","length":129,"sequence":"VEVATHYLEIITQLIVESFHFKNGEDAPDLLKVITKPFTKLIVQLDKKVISQIAMNDEKAKNKSLVKIWCKTFTNKTQINVTVPSTANCTSPSLCWTDGIQNWTMKNVTYKENIAKCQHIFVNFHLPDL","sequence_sha256":"964c4be47604821cc47f72af73331a636eb688d839c7638b76b1e93fc956b9ea","start":234},{"basis":"reviewed-uniprot-topological-domain","end":485,"evidence_class":"source-annotated-topology","length":57,"sequence":"IVQSSSVFTSALTPLIGIGVITIERAYPLTLGSNIGTTTTAILAALASPGNALRSSL","sequence_sha256":"0183894c145574f200dbc96b2c6fb3fed24619d7eafea9431d7ed7f7def64057","start":429},{"basis":"reviewed-uniprot-topological-domain","end":552,"evidence_class":"source-annotated-topology","length":6,"sequence":"LSLAGW","sequence_sha256":"bc776b938b925066f4d91cc281af61e0e7941842d7c16305f7762718c499ccbd","start":547}],"state":"source-annotated"},"gene_symbol":"SLC34A2","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MAPWPELGDAQPNPDKYLEGAAGQQPTAPDKSKETNKTDNTEAPVTKIELLPSYSTATLIDEPTEVDDPWNLPTLQDSGIKWSERDTKGKILCFFQGIGRLILLLGFLYFFVCSLDILSSAFQLVGGKMAGQFFSNSSIMSNPLLGLVIGVLVTVLVQSSSTSTSIVVSMVSSSLLTVRAAIPIIMGANIGTSITNTIVALMQVGDRSEFRRAFAGATVHDFFNWLSVLVLLPVEVATHYLEIITQLIVESFHFKNGEDAPDLLKVITKPFTKLIVQLDKKVISQIAMNDEKAKNKSLVKIWCKTFTNKTQINVTVPSTANCTSPSLCWTDGIQNWTMKNVTYKENIAKCQHIFVNFHLPDLAVGTILLILSLLVLCGCLIMIVKILGSVLKGQVATVIKKTINTDFPFPFAWLTGYLAILVGAGMTFIVQSSSVFTSALTPLIGIGVITIERAYPLTLGSNIGTTTTAILAALASPGNALRSSLQIALCHFFFNISGILLWYPIPFTRLPIRMAKGLGNISAKYRWFAVFYLIIFFFLIPLTVFGLSLAGWRVLVGVGVPVVFIIILVLCLRLLQSRCPRVLPKKLQNWNFLPLWMRSLKPWDAVVSKFTGCFQMRCCCCCRVCCRACCLLCDCPKCCRCSKCCEDLEEAQEGQDVPVKAPETFDNITISREAQGEVPASDSKTECTAL","length":690,"sha256":"33ce6c59e28a7373fce51debe32cec8d891ef691c2e77a0655a74040da25eef9","state":"available"},"source_refs":[{"artifact":{"bytes":5988,"format":"json","sha256":"3d9aac403b6eff3ce404fc1967369e495d0bd1457027ca601085bbb9da517ed2","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/O95436"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"O95436","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"retained-unmodeled","target_id":"T-ENSG00000157765","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":690},"entry_name":"NPT2B_HUMAN","gene_names":"SLC34A2","lipidation_sites":[],"protein_names":"Sodium-dependent phosphate transport protein 2B (Sodium-phosphate transport protein 2B) (Na(+)-dependent phosphate cotransporter 2B) (NaPi3b) (Sodium/phosphate cotransporter 2B) (Na(+)/Pi cotransporter 2B) (NaPi-2b) (Solute carrier family 34 member 2)","raw_fields":{"lipidation":"","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q9DBP0}; Multi-pass membrane protein {ECO:0000255}. Note=Localized at the brush border membranes of enterocytes. {ECO:0000250|UniProtKB:Q9DBP0}.","topological_domain":"TOPO_DOM 1..100; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 122..135; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 157..212; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 234..362; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 384..407; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 429..485; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 507..525; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 547..552; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"; TOPO_DOM 574..689; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 101..121; /note=\"Helical; Name=M1\"; /evidence=\"ECO:0000255\"; TRANSMEM 136..156; /note=\"Helical; Name=M2\"; /evidence=\"ECO:0000255\"; TRANSMEM 213..233; /note=\"Helical; Name=M3\"; /evidence=\"ECO:0000255\"; TRANSMEM 363..383; /note=\"Helical; Name=M4\"; /evidence=\"ECO:0000255\"; TRANSMEM 408..428; /note=\"Helical; Name=M5\"; /evidence=\"ECO:0000255\"; TRANSMEM 486..506; /note=\"Helical; Name=M6\"; /evidence=\"ECO:0000255\"; TRANSMEM 526..546; /note=\"Helical; Name=M7\"; /evidence=\"ECO:0000255\"; TRANSMEM 553..573; /note=\"Helical; Name=M8\"; /evidence=\"ECO:0000255\""},"signal_peptides":[],"state":"available","topological_domains":[{"description":"Cytoplasmic","end":100,"evidence":"ECO:0000255","source_location":"TOPO_DOM 1..100; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":1},{"description":"Extracellular","end":135,"evidence":"ECO:0000255","source_location":"TOPO_DOM 122..135; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":122},{"description":"Cytoplasmic","end":212,"evidence":"ECO:0000255","source_location":"TOPO_DOM 157..212; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":157},{"description":"Extracellular","end":362,"evidence":"ECO:0000255","source_location":"TOPO_DOM 234..362; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":234},{"description":"Cytoplasmic","end":407,"evidence":"ECO:0000255","source_location":"TOPO_DOM 384..407; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":384},{"description":"Extracellular","end":485,"evidence":"ECO:0000255","source_location":"TOPO_DOM 429..485; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":429},{"description":"Cytoplasmic","end":525,"evidence":"ECO:0000255","source_location":"TOPO_DOM 507..525; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":507},{"description":"Extracellular","end":552,"evidence":"ECO:0000255","source_location":"TOPO_DOM 547..552; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":547},{"description":"Cytoplasmic","end":689,"evidence":"ECO:0000255","source_location":"TOPO_DOM 574..689; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":574}],"transmembrane_segments":[{"description":"Helical; Name=M1","end":121,"evidence":"ECO:0000255","source_location":"TRANSMEM 101..121; 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Single-pass type II membrane protein. Basolateral cell membrane {ECO:0000269|PubMed:11598187}; Single-pass type II membrane protein. Note=Targeted to the basolateral membrane in polarized epithelial cells and in hepatocytes, and to matrix vesicles in osteoblasts (PubMed:11598187). In bile duct cells and cancer cells, located to the apical cytoplasmic side (PubMed:11598187). {ECO:0000269|PubMed:11598187}.; SUBCELLULAR LOCATION: [Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form]: Secreted {ECO:0000250|UniProtKB:P06802}. Note=Secreted following proteolytic cleavage. {ECO:0000250|UniProtKB:P06802}.","topological_domain":"TOPO_DOM 1..76; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"; TOPO_DOM 98..925; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","transmembrane":"TRANSMEM 77..97; /note=\"Helical; Signal-anchor for type II membrane protein\"; /evidence=\"ECO:0000255\""},"signal_peptides":[],"state":"available","topological_domains":[{"description":"Cytoplasmic","end":76,"evidence":"ECO:0000255","source_location":"TOPO_DOM 1..76; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000255\"","start":1},{"description":"Extracellular","end":925,"evidence":"ECO:0000255","source_location":"TOPO_DOM 98..925; /note=\"Extracellular\"; /evidence=\"ECO:0000255\"","start":98}],"transmembrane_segments":[{"description":"Helical; Signal-anchor for type II membrane protein","end":97,"evidence":"ECO:0000255","source_location":"TRANSMEM 77..97; /note=\"Helical; Signal-anchor for type II membrane protein\"; /evidence=\"ECO:0000255\"","start":77}]},"uniprot_accession":"P22413"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000110195","evidence_rank":163,"extracellular_segments":{"records":[{"basis":"interval-after-reviewed-signal-before-reviewed-gpi-anchor","end":233,"evidence_class":"topology-derived-construct-hypothesis","length":209,"sequence":"RIAWARTELLNVCMNAKHHKEKPGPEDKLHEQCRPWRKNACCSTNTSQEAHKDVSYLYRFNWNHCGEMAPACKRHFIQDTCLYECSPNLGPWIQQVDQSWRKERVLNVPLCKEDCEQWWEDCRTSYTCKSNWHKGWNWTSGFNKCAVGAACQPFHFYFPTPTVLCNEIWTHSYKVSNYSRGSGRCIQMWFDPAQGNPNEEVARFYAAAM","sequence_sha256":"1763e0ca38ce45887dd74a5254ea2af226763fe5e4d022b64cbdb8be0a9e4bb2","start":25}],"state":"topology-derived-gpi-span"},"gene_symbol":"FOLR1","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MAQRMTTQLLLLLVWVAVVGEAQTRIAWARTELLNVCMNAKHHKEKPGPEDKLHEQCRPWRKNACCSTNTSQEAHKDVSYLYRFNWNHCGEMAPACKRHFIQDTCLYECSPNLGPWIQQVDQSWRKERVLNVPLCKEDCEQWWEDCRTSYTCKSNWHKGWNWTSGFNKCAVGAACQPFHFYFPTPTVLCNEIWTHSYKVSNYSRGSGRCIQMWFDPAQGNPNEEVARFYAAAMSGAGPWAAWPFLLSLALMLLWLLS","length":257,"sha256":"32c0a619bf0594c065d065d7e221ae2f11c85a62b9d2c5337b44f3930ba58400","state":"available"},"source_refs":[{"artifact":{"bytes":2219,"format":"json","sha256":"16539879c5c6d39a02d1855faed565250472b2442881712c25bc6c6799df8d7f","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/P15328"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"P15328","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"retained-unmodeled","target_id":"T-ENSG00000110195","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":257},"entry_name":"FOLR1_HUMAN","gene_names":"FOLR1 FOLR","lipidation_sites":[{"description":"GPI-anchor amidated serine","end":234,"evidence":"ECO:0000269|PubMed:17566972, ECO:0000269|PubMed:7578066","source_location":"LIPID 234; /note=\"GPI-anchor amidated serine\"; /evidence=\"ECO:0000269|PubMed:17566972, ECO:0000269|PubMed:7578066\"","start":234}],"protein_names":"Folate receptor alpha (FR-alpha) (Adult folate-binding protein) (FBP) (Folate receptor 1) (Folate receptor, adult) (KB cells FBP) (Ovarian tumor-associated antigen MOv18)","raw_fields":{"lipidation":"LIPID 234; /note=\"GPI-anchor amidated serine\"; /evidence=\"ECO:0000269|PubMed:17566972, ECO:0000269|PubMed:7578066\"","signal_peptide":"SIGNAL 1..24; /evidence=\"ECO:0000255\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:2527252, ECO:0000269|PubMed:8033114, ECO:0000269|PubMed:8567728}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:17566972, ECO:0000269|PubMed:7578066}. Apical cell membrane {ECO:0000269|PubMed:10787414}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:17566972, ECO:0000269|PubMed:7578066}. Basolateral cell membrane {ECO:0000269|PubMed:10787414}; Lipid-anchor, GPI-like-anchor {ECO:0000269|PubMed:17566972, ECO:0000269|PubMed:7578066}. Secreted {ECO:0000305|PubMed:3476960}. Cytoplasmic vesicle {ECO:0000269|PubMed:8567728}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:8567728}. Endosome {ECO:0000269|PubMed:8567728}. Note=Endocytosed into cytoplasmic vesicles and then recycled to the cell membrane. {ECO:0000269|PubMed:8567728}.","topological_domain":"","transmembrane":""},"signal_peptides":[{"description":null,"end":24,"evidence":"ECO:0000255","source_location":"SIGNAL 1..24; /evidence=\"ECO:0000255\"","start":1}],"state":"available","topological_domains":[],"transmembrane_segments":[]},"uniprot_accession":"P15328"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000198910","evidence_rank":164,"extracellular_segments":{"records":[{"basis":"reviewed-uniprot-topological-domain","end":1120,"evidence_class":"source-annotated-topology","length":1101,"sequence":"IQIPEEYEGHHVMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFSTPEGVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQATTKEGPGEAIVREGGTMALSGISDFGNISATAGENYSVVSWVPKEGQCNFRFHILFKALGEEKGGASLSPQYVSYNQSSYTQWDLQPDTDYEIHLFKERMFRHQMAVKTNGTGRVRLPPAGFATE","sequence_sha256":"ee0bd09fb94f65bdc4ad7b079165201daf8c065b0ec89de0e723f26d72d15acf","start":20}],"state":"source-annotated"},"gene_symbol":"L1CAM","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MVVALRYVWPLLLCSPCLLIQIPEEYEGHHVMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFSTPEGVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQATTKEGPGEAIVREGGTMALSGISDFGNISATAGENYSVVSWVPKEGQCNFRFHILFKALGEEKGGASLSPQYVSYNQSSYTQWDLQPDTDYEIHLFKERMFRHQMAVKTNGTGRVRLPPAGFATEGWFIGFVSAIILLLLVLLILCFIKRSKGGKYSVKDKEDTQVDSEARPMKDETFGEYRSLESDNEEKAFGSSQPSLNGDIKPLGSDDSLADYGGSVDVQFNEDGSFIGQYSGKKEKEAAGGNDSSGATSPINPAVALE","length":1257,"sha256":"5decc8013d23181976e7f7ac6ce215562fad67f012b82010dea68fbc53f7164e","state":"available"},"source_refs":[{"artifact":{"bytes":12197,"format":"json","sha256":"7eb26b357daaf0d47e05810d9be898dfe147a56c05de15f9919b0aa82b4c0e50","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/P32004"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"P32004","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"retained-unmodeled","target_id":"T-ENSG00000198910","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":1257},"entry_name":"L1CAM_HUMAN","gene_names":"L1CAM CAML1 MIC5","lipidation_sites":[],"protein_names":"Neural cell adhesion molecule L1 (N-CAM-L1) (NCAM-L1) (CD antigen CD171)","raw_fields":{"lipidation":"","signal_peptide":"SIGNAL 1..19; /evidence=\"ECO:0000269|PubMed:3136168\"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12514225, ECO:0000269|PubMed:20621658, ECO:0000269|PubMed:22973895, ECO:0000269|PubMed:26891472}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q05695}. 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Cell membrane {ECO:0000250|UniProtKB:Q4LDG0}; Multi-pass membrane protein {ECO:0000255}.","topological_domain":"TOPO_DOM 1..30; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000305|PubMed:11980911\"; TOPO_DOM 77..690; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000305|PubMed:11980911\"","transmembrane":"TRANSMEM 31..51; /note=\"Helical\"; /evidence=\"ECO:0000255\"; TRANSMEM 56..76; /note=\"Helical\"; /evidence=\"ECO:0000255\""},"signal_peptides":[],"state":"available","topological_domains":[{"description":"Cytoplasmic","end":30,"evidence":"ECO:0000305|PubMed:11980911","source_location":"TOPO_DOM 1..30; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000305|PubMed:11980911\"","start":1},{"description":"Cytoplasmic","end":690,"evidence":"ECO:0000305|PubMed:11980911","source_location":"TOPO_DOM 77..690; /note=\"Cytoplasmic\"; /evidence=\"ECO:0000305|PubMed:11980911\"","start":77}],"transmembrane_segments":[{"description":"Helical","end":51,"evidence":"ECO:0000255","source_location":"TRANSMEM 31..51; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":31},{"description":"Helical","end":76,"evidence":"ECO:0000255","source_location":"TRANSMEM 56..76; /note=\"Helical\"; /evidence=\"ECO:0000255\"","start":56}]},"uniprot_accession":"Q9Y2P5"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000050405","evidence_rank":173,"extracellular_segments":{"records":[],"state":"not-explicitly-annotated"},"gene_symbol":"LIMA1","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MESSPFNRRQWTSLSLRVTAKELSLVNKNKSSAIVEIFSKYQKAAEETNMEKKRSNTENLSQHFRKGTLTVLKKKWENPGLGAESHTDSLRNSSTEIRHRADHPPAEVTSHAASGAKADQEEQIHPRSRLRSPPEALVQGRYPHIKDGEDLKDHSTESKKMENCLGESRHEVEKSEISENTDASGKIEKYNVPLNRLKMMFEKGEPTQTKILRAQSRSASGRKISENSYSLDDLEIGPGQLSSSTFDSEKNESRRNLELPRLSETSIKDRMAKYQAAVSKQSSSTNYTNELKASGGEIKIHKMEQKENVPPGPEVCITHQEGEKISANENSLAVRSTPAEDDSRDSQVKSEVQQPVHPKPLSPDSRASSLSESSPPKAMKKFQAPARETCVECQKTVYPMERLLANQQVFHISCFRCSYCNNKLSLGTYASLHGRIYCKPHFNQLFKSKGNYDEGFGHRPHKDLWASKNENEEILERPAQLANARETPHSPGVEDAPIAKVGVLAASMEAKASSQQEKEDKPAETKKLRIAWPPPTELGSSGSALEEGIKMSKPKWPPEDEISKPEVPEDVDLDLKKLRRSSSLKERSRPFTVAASFQSTSVKSPKTVSPPIRKGWSMSEQSEESVGGRVAERKQVENAKASKKNGNVGKTTWQNKESKGETGKRSKEGHSLEMENENLVENGADSDEDDNSFLKQQSPQEPKSLNWSSFVDNTFAEEFTTQNQKSQDVELWEGEVVKELSVEEQIKRNRYYDEDEDEE","length":759,"sha256":"d09ccefe7c2bfdced1a34d5b22166e6c404cde3a727eb657af6f0552c68bdaf5","state":"available"},"source_refs":[{"artifact":{"bytes":14006,"format":"json","sha256":"63e3dd9b82cf4617e2e09bee8be5689c83413376c9175925a61f4f15bf3bbfad","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/Q9UHB6"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"Q9UHB6","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"retained-unmodeled","target_id":"T-ENSG00000050405","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":759},"entry_name":"LIMA1_HUMAN","gene_names":"LIMA1 EPLIN SREBP3 PP624","lipidation_sites":[],"protein_names":"LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm)","raw_fields":{"lipidation":"","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cytoplasm. Cell junction, focal adhesion {ECO:0000269|PubMed:10618726, ECO:0000269|PubMed:24694988}. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:10618726}. Cell membrane {ECO:0000250|UniProtKB:Q9ERG0}. Cell projection, ruffle {ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. Cell projection, lamellipodium {ECO:0000269|PubMed:33999101}. Note=Expressed in the brush border membrane of the small intestine and colocalizes with NPC1L1 and MYO5B (PubMed:29880681). Colocalizes with PXN at focal adhesions in mesangial cells (PubMed:24694988). Colocalizes with actin stress fibers in quiescent cells. PDGF stimulation induced disassembly of stress fibers and formation of peripheral and dorsal ruffles, where LIMA1 is relocalized (By similarity). Localized at the lamellipodia, just behind lamellipodia actin ruffles (PubMed:33999101). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:24694988, ECO:0000269|PubMed:29880681, ECO:0000269|PubMed:33999101}.","topological_domain":"","transmembrane":""},"signal_peptides":[],"state":"available","topological_domains":[],"transmembrane_segments":[]},"uniprot_accession":"Q9UHB6"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000147162","evidence_rank":174,"extracellular_segments":{"records":[],"state":"not-explicitly-annotated"},"gene_symbol":"OGT","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MASSVGNVADSTEPTKRMLSFQGLAELAHREYQAGDFEAAERHCMQLWRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYPLSHGFRKAIAERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYVSSDFGNHPTSHLMQSIPGMHNPDKFEVFCYALSPDDGTNFRVKVMAEANHFIDLSQIPCNGKAADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSGALFMDYIITDQETSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHLKKKAVIDFKSNGHIYDNRIVLNGIDLKAFLDSLPDVKIVKMKCPDGGDNADSSNTALNMPVIPMNTIAEAVIEMINRGQIQITINGFSISNGLATTQINNKAATGEEVPRTIIVTTRSQYGLPEDAIVYCNFNQLYKIDPSTLQMWANILKRVPNSVLWLLRFPAVGEPNIQQYAQNMGLPQNRIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMPGETLASRVAASQLTCLGCLELIAKNRQEYEDIAVKLGTDLEYLKKVRGKVWKQRISSPLFNTKQYTMELERLYLQMWEHYAAGNKPDHMIKPVEVTESA","length":1046,"sha256":"b606c098eae182300f53c1c144db0b2dcc69e268edb382758e324acb4ebe6ea2","state":"available"},"source_refs":[{"artifact":{"bytes":13669,"format":"json","sha256":"4780877c88fc27cc0270a0b3c96cda92d538e56724741bb23535f56edeaa3c3b","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/O15294"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"O15294","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"retained-unmodeled","target_id":"T-ENSG00000147162","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":1046},"entry_name":"OGT1_HUMAN","gene_names":"OGT","lipidation_sites":[],"protein_names":"UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (EC 2.4.1.255) (O-GlcNAc transferase subunit p110) (O-linked N-acetylglucosamine transferase 110 kDa subunit) (OGT)","raw_fields":{"lipidation":"","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26678539, ECO:0000269|PubMed:27713473}. Cytoplasm {ECO:0000269|PubMed:26678539, ECO:0000269|PubMed:27713473}. Note=Predominantly localizes to the nucleus (PubMed:26678539). Translocates into the nucleus via association with importin KPNA1 (PubMed:27713473). {ECO:0000269|PubMed:26678539, ECO:0000269|PubMed:27713473}.; SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion {ECO:0000269|PubMed:20824293}. Membrane {ECO:0000269|PubMed:20824293}. Note=Associates with the mitochondrial inner membrane. {ECO:0000269|PubMed:20824293}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:21285374}. Nucleus {ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:21285374}. Cell membrane {ECO:0000250|UniProtKB:P56558}. Mitochondrion membrane {ECO:0000250|UniProtKB:P56558}. Cell projection {ECO:0000250|UniProtKB:P56558}. Note=Mostly in the nucleus. Retained in the nucleus via interaction with HCFC1 (PubMed:21285374). After insulin induction, translocated from the nucleus to the cell membrane via phosphatidylinositide binding. Colocalizes with AKT1 at the plasma membrane. TRAK1 recruits this protein to mitochondria. In the absence of TRAK1, localizes in cytosol and nucleus (By similarity). {ECO:0000250|UniProtKB:P56558, ECO:0000269|PubMed:21285374}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000303|PubMed:31527085}. Nucleus {ECO:0000303|PubMed:31527085}.","topological_domain":"","transmembrane":""},"signal_peptides":[],"state":"available","topological_domains":[],"transmembrane_segments":[]},"uniprot_accession":"O15294"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000198561","evidence_rank":175,"extracellular_segments":{"records":[],"state":"not-explicitly-annotated"},"gene_symbol":"CTNND1","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MDDSEVESTASILASVKEQEAQFEKLTRALEEERRHVSAQLERVRVSPQDANPLMANGTLTRRHQNGRFVGDADLERQKFSDLKLNGPQDHSHLLYSTIPRMQEPGQIVETYTEEDPEGAMSVVSVETSDDGTTRRTETTVKKVVKTVTTRTVQPVAMGPDGLPVDASSVSNNYIQTLGRDFRKNGNGGPGPYVGQAGTATLPRNFHYPPDGYSRHYEDGYPGGSDNYGSLSRVTRIEERYRPSMEGYRAPSRQDVYGPQPQVRVGGSSVDLHRFHPEPYGLEDDQRSMGYDDLDYGMMSDYGTARRTGTPSDPRRRLRSYEDMIGEEVPSDQYYWAPLAQHERGSLASLDSLRKGGPPPPNWRQPELPEVIAMLGFRLDAVKSNAAAYLQHLCYRNDKVKTDVRKLKGIPVLVGLLDHPKKEVHLGACGALKNISFGRDQDNKIAIKNCDGVPALVRLLRKARDMDLTEVITGTLWNLSSHDSIKMEIVDHALHALTDEVIIPHSGWEREPNEDCKPRHIEWESVLTNTAGCLRNVSSERSEARRKLRECDGLVDALIFIVQAEIGQKDSDSKLVENCVCLLRNLSYQVHREIPQAERYQEAAPNVANNTGPHAASCFGAKKGKDEWFSRGKKPIEDPANDTVDFPKRTSPARGYELLFQPEVVRIYISLLKESKTPAILEASAGAIQNLCAGRWTYGRYIRSALRQEKALSAIADLLTNEHERVVKAASGALRNLAVDARNKELIGKHAIPNLVKNLPGGQQNSSWNFSEDTVISILNTINEVIAENLEAAKKLRETQGIEKLVLINKSGNRSEKEVRAAALVLQTIWGYKELRKPLEKEGWKKSDFQVNLNNASRSQSSHSYDDSTLPLIDRNQKSDKKPDREEIQMSNMGSNTKSLDNNYSTPNERGDHNRTLDRSGDLGDMEPLKGTTPLMQDEGQESLEEELDVLVLDDEGGQVSYPSMQKI","length":968,"sha256":"3654c491186ae9d8a1ff3ccfdd2d1fcaa05e4f792654a32899f5896089dc67e8","state":"available"},"source_refs":[{"artifact":{"bytes":99757,"format":"json","sha256":"5c7d66f6119d255f69ef393963aff55bb7cf29a42df1238eb22ab961cd22cf47","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/O60716"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"O60716","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"retained-unmodeled","target_id":"T-ENSG00000198561","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":968},"entry_name":"CTND1_HUMAN","gene_names":"CTNND1 KIAA0384","lipidation_sites":[],"protein_names":"Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas))","raw_fields":{"lipidation":"","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000269|PubMed:11896187}. Cytoplasm {ECO:0000269|PubMed:15240885, ECO:0000269|PubMed:17047063}. Nucleus {ECO:0000269|PubMed:11896187, ECO:0000269|PubMed:17115030}. Cell membrane {ECO:0000269|PubMed:15240885, ECO:0000269|PubMed:17047063}. Cell junction {ECO:0000269|PubMed:18343367}. Note=Interaction with GLIS2 promotes nuclear translocation (By similarity). Detected at cell-cell contacts (PubMed:15240885, PubMed:17047063). NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm (PubMed:17047063). CDH1 enhances cell membrane localization (PubMed:15240885). Localizes to cell-cell contacts as keratinocyte differentiation progresses (By similarity). {ECO:0000250|UniProtKB:P30999, ECO:0000269|PubMed:11896187, ECO:0000269|PubMed:15240885, ECO:0000269|PubMed:17047063}.; SUBCELLULAR LOCATION: [Isoform 1A]: Nucleus {ECO:0000269|PubMed:11896187}.; SUBCELLULAR LOCATION: [Isoform 2A]: Nucleus {ECO:0000269|PubMed:11896187}.; SUBCELLULAR LOCATION: [Isoform 3A]: Nucleus {ECO:0000269|PubMed:11896187}.; SUBCELLULAR LOCATION: [Isoform 4A]: Cytoplasm {ECO:0000269|PubMed:11896187}.; SUBCELLULAR LOCATION: [Isoform 1AB]: Cytoplasm {ECO:0000269|PubMed:11896187}.","topological_domain":"","transmembrane":""},"signal_peptides":[],"state":"available","topological_domains":[],"transmembrane_segments":[]},"uniprot_accession":"O60716"},{"accession_mapping":{"candidate_accessions":[],"state":"target-primary-accession"},"claim_ceiling":"canonical protein sequence and reviewed UniProt topology annotation; extracellular intervals are source-annotated or explicitly topology-derived and are not expression, surface-density, binding, efficacy, or safety evidence","ensembl_gene_id":"ENSG00000197122","evidence_rank":176,"extracellular_segments":{"records":[],"state":"not-explicitly-annotated"},"gene_symbol":"SRC","sequence":{"alphabet":"UniProt protein sequence uppercase letters","canonical":true,"full_sequence":"MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL","length":536,"sha256":"bfb0c691493b552212f52a3e68ec9d6c2e67dc37339f19b6e71c22fd202292f8","state":"available"},"source_refs":[{"artifact":{"bytes":7954,"format":"json","sha256":"6d79df371835baac31e17ffa6527203caada14150dc980954eb36d0d02aac355","storage":"external-artifact-root"},"extracted_field":"uniprotSequence","role":"canonical-sequence","source":"alphafold-db-canonical-uniprot-field","source_url":"https://www.uniprot.org/uniprotkb/P12931"},{"artifact":{"bytes":10393994,"format":"tsv","sha256":"17b0f61e4a17f57e099de54d7f736ebc882936bad87c33c269d35bd6714be77d","storage":"external-artifact-root"},"role":"reviewed-topology","row_accession":"P12931","source":"UniProt reviewed human surface-field snapshot"}],"structure_tier":"retained-unmodeled","target_id":"T-ENSG00000197122","topology":{"coordinate_validation":{"all_features_in_range":true,"invalid_features":[],"sequence_length":536},"entry_name":"SRC_HUMAN","gene_names":"SRC SRC1","lipidation_sites":[{"description":"N-myristoyl glycine","end":2,"evidence":"ECO:0000269|PubMed:7525268","source_location":"LIPID 2; /note=\"N-myristoyl glycine\"; /evidence=\"ECO:0000269|PubMed:7525268\"","start":2}],"protein_names":"Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)","raw_fields":{"lipidation":"LIPID 2; /note=\"N-myristoyl glycine\"; /evidence=\"ECO:0000269|PubMed:7525268\"","signal_peptide":"","subcellular_location":"SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:7525268}; Lipid-anchor {ECO:0000269|PubMed:22801373}. Mitochondrion inner membrane {ECO:0000269|PubMed:12615910}. Nucleus {ECO:0000269|PubMed:7853507}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:7525268}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19307596}. Cell junction, focal adhesion {ECO:0000269|PubMed:22801373}. Cell junction {ECO:0000269|PubMed:22294297}. Note=Localizes to focal adhesion sites following integrin engagement (PubMed:22801373). Localization to focal adhesion sites requires myristoylation and the SH3 domain (PubMed:7525268). 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