Surface AtlasCampaign results
Review the FAP and CD73 molecule screens and the integrin αvβ6 and CEACAM5 protein designs. Open each study’s structures, measurements, and control results.
FAP · molecule screening
Completed control and repeat-run checks
The charge-aware docking screen completed its recorded control checks. Five selected molecules passed repeat-run checks within this protocol.
Open FAP screen →CD73 / NT5E · molecule screening
Completed control and repeat-run checks
The fixed zero-charge docking screen completed its recorded control checks. Five selected molecules passed repeat-run checks within this protocol.
Open CD73 screen →Integrin αvβ6 · binder design
Candidate geometry checks failed
Reference controls passed. Fourteen candidate predictions were scored; none met the reference-site geometry criteria. Two additional predictions could not be scored.
Explore integrin designs →CEACAM5 · original design comparison
Common screen not run
Three methods generated nine candidates; four passed local geometry checks. FreeBindCraft returned no candidate, leaving the four-method cohort incomplete. The planned common independent screen was not run.
Open original design comparison →CEACAM5 · predictions with controls
Control checks failed
The positive control’s interface score (ipSAE-min) was 0.216434, below the required 0.25. It contacted 9 reference-site residues; the shuffled control contacted 13. These control failures stopped candidate selection.
Open predictions and controls →CEACAM5 · paired-domain control
Diagnostic stopped
The completed model contains CEACAM5 with the heavy- and light-chain variable domains of tusamitamab. A local scoring incompatibility stopped the remaining five predictions.
Open paired-domain study →CEACAM5 · replacement generators
Candidate geometry checks failed
ESMFold2 generated three candidates without a target-site constraint; all three failed the site-geometry checks. Genie3 failed its target-coordinate recovery check. Independent predictions were not run.
Open replacement study →