Molecular strategies

Review proposed ways to act on a target, such as blocking an interaction or delivering a payload. Compare each target’s supporting measurements, proposed molecular work, and available binding sites.

Plan a binding-site comparison

TARGETCEACAM5
Review the protein’s cell context and extracellular region.
BINDING SITETusamitamab interface
Use the contact region recorded in structure 8BW0.
PROPOSED ACTIONBind the epitope
Generate a molecule for this antibody-contact region.
COMPUTATIONAL CHECKCompare contacts
Compare predicted target contacts with the published interface.

Target evidence and proposed molecular work

This table records proposed molecular work for each target. Campaign results reports completed computations.

The matrix covers 50 targets and lists 82 proposed tasks: 52 molecular tasks and 30 site-discovery tasks. Molecular format scores guide experiment selection; activity and efficacy require measurements.
Target	Proposed molecular work	Available site	Supporting records
CEACAM5T-ENSG00000105388	3 proposed tasks bind or occupy observed deposited epitope evaluate target associated molecular imaging route evaluate target associated radionuclide delivery route	1 sitederived deposited sitePDB 8BW0	View records Tier / rank Structure A · full reviewresource rank 1 Cell context UnresolvedUnresolvedCompare recorded cell populations Observed intervention evidence molecular imaging (1) antibody (2) car nk cell therapy (2) car t cell therapy (4) molecular imaging agent (4) radioligand therapy (1) Measured target-level compound records: 0Compound coverage: queried no selected records Molecular format scores Antibody Format Binder · 100.0/100 Engineered Cell Therapy · 92/100 Miniprotein Binder · 90/100 Planning limits and missing evidence candidate generation and promotion not in scope cell owner context unresolved no selected measured compound records in bounded source coverage
EGFRT-ENSG00000146648	8 proposed tasks bind or occupy observed deposited epitope evaluate target associated molecular imaging route evaluate target associated payload delivery route evaluate target associated radionuclide delivery route test target associated antagonism after site and assay resolution test target associated binding after site selection test target associated blockade after partner or site resolution test target associated inhibition after site and assay resolution	1 sitederived deposited sitePDB 1YY9	View records Tier / rank Structure A · full reviewresource rank 2 Cell context StromalProvisional Transcript ContextCells with highest recorded RNA detection: fibroblast · 16.0% expressingCompare recorded cell populations Observed intervention evidence Read details antagonist (2) binder (3) blocker (2) cytotoxic payload delivery (2) inhibitor (2) antibody (8) antibody drug conjugate (1) bispecific antibody (2) bispecific antibody drug conjugate (1) conventional cytotoxic regimen (1) molecular imaging agent (1) radioligand therapy (1) Measured target-level compound records: 10Compound coverage: represented Molecular format scores Antibody Format Binder · 100.0/100 Antibody Drug Conjugate · 95/100 Miniprotein Binder · 85/100 Planning limits and missing evidence candidate generation and promotion not in scope cell owner routing remains provisional transcript context
ERBB2T-ENSG00000141736	5 proposed tasks bind or occupy observed deposited epitope evaluate target associated molecular imaging route evaluate target associated payload delivery route test target associated binding after site selection test target associated inhibition after site and assay resolution	1 sitederived deposited sitePDB 1N8Z	View records Tier / rank Structure A · full reviewresource rank 3 Cell context Malignant EpithelialProvisional Transcript ContextCells with highest recorded RNA detection: tumor · 21.7% expressingCompare recorded cell populations Observed intervention evidence Read details binder (2) cytotoxic payload delivery (2) inhibitor (1) molecular imaging (2) antibody (2) antibody drug conjugate (2) bispecific antibody (1) car t cell therapy (1) conventional cytotoxic regimen (2) molecular imaging agent (2) other or unclear (1) small molecule (1) Measured target-level compound records: 10Compound coverage: represented Molecular format scores Antibody Format Binder · 100.0/100 Antibody Drug Conjugate · 95/100 Engineered Cell Therapy · 92/100 Planning limits and missing evidence candidate generation and promotion not in scope cell owner routing remains provisional transcript context
EPCAMT-ENSG00000119888	1 proposed task bind or occupy observed deposited epitope	1 sitederived deposited sitePDB 6I07	View records Tier / rank Structure A · full reviewresource rank 4 Cell context Malignant EpithelialProvisional Transcript ContextCells with highest recorded RNA detection: tumor · 61.6% expressingCompare recorded cell populations Observed intervention evidence car t cell therapy (3) Measured target-level compound records: 2Compound coverage: represented Molecular format scores Antibody Format Binder · 95/100 Engineered Cell Therapy · 92/100 Miniprotein Binder · 90/100 Planning limits and missing evidence action unresolved in assigned intervention records candidate generation and promotion not in scope cell owner routing remains provisional transcript context
METT-ENSG00000105976	7 proposed tasks compete at observed natural ligand interface bind or occupy observed deposited epitope evaluate target associated molecular imaging route evaluate target associated payload delivery route evaluate target associated radionuclide delivery route test target associated binding after site selection test target associated blockade after partner or site resolution	2 sitesderived deposited sitePDB 4K3J	View records Tier / rank Structure A · full reviewresource rank 5 Cell context Malignant EpithelialProvisional Transcript ContextCells with highest recorded RNA detection: tumor · 14.8% expressingCompare recorded cell populations Observed intervention evidence binder (2) blocker (2) cytotoxic payload delivery (1) antibody drug conjugate (1) bispecific antibody (2) molecular imaging agent (2) radioligand therapy (1) Measured target-level compound records: 10Compound coverage: represented Molecular format scores Antibody Format Binder · 100.0/100 Antibody Drug Conjugate · 95/100 Miniprotein Binder · 85/100 Planning limits and missing evidence candidate generation and promotion not in scope cell owner routing remains provisional transcript context
TACSTD2T-ENSG00000184292	3 proposed tasks bind or occupy observed deposited epitope evaluate target associated molecular imaging route evaluate target associated payload delivery route	1 sitederived deposited sitePDB 9PI9	View records Tier / rank Structure A · full reviewresource rank 6 Cell context Malignant EpithelialProvisional Transcript ContextCells with highest recorded RNA detection: tumor · 19.4% expressingCompare recorded cell populations Observed intervention evidence molecular imaging (2) antibody drug conjugate (1) molecular imaging agent (2) Measured target-level compound records: 0Compound coverage: queried no selected records Molecular format scores Antibody Format Binder · 100.0/100 Antibody Drug Conjugate · 95/100 Miniprotein Binder · 85/100 Planning limits and missing evidence candidate generation and promotion not in scope cell owner routing remains provisional transcript context no selected measured compound records in bounded source coverage
NT5ET-ENSG00000135318	3 proposed tasks bind or occupy observed deposited epitope reproduce or compete at observed deposited small molecule pocket test target associated inhibition after site and assay resolution	2 sitesderived deposited sitePDB 7BBJ, 9R0G	View records Tier / rank Structure A · full reviewresource rank 7 Cell context StromalProvisional Transcript ContextCells with highest recorded RNA detection: fibroblast · 24.1% expressingCompare recorded cell populations Observed intervention evidence inhibitor (1) antibody (2) small molecule (1) Measured target-level compound records: 10Compound coverage: represented Molecular format scores Antibody Format Binder · 100.0/100 Small Molecule · 98/100 Miniprotein Binder · 85/100 Planning limits and missing evidence candidate generation and promotion not in scope cell owner routing remains provisional transcript context
GUCY2CT-ENSG00000070019	1 proposed task bind or occupy observed deposited epitope	1 sitederived deposited sitePDB 8GHP	View records Tier / rank Structure A · full reviewresource rank 8 Cell context UnresolvedUnresolvedCompare recorded cell populations Observed intervention evidence car nk cell therapy (2) car t cell therapy (2) Measured target-level compound records: 0Compound coverage: queried no selected records Molecular format scores Engineered Cell Therapy · 92/100 Antibody Format Binder · 90/100 Miniprotein Binder · 85/100 Planning limits and missing evidence action unresolved in assigned intervention records candidate generation and promotion not in scope cell owner context unresolved no selected measured compound records in bounded source coverage
FAPT-ENSG00000078098	2 proposed tasks reproduce or compete at observed deposited inhibitor pocket bind or occupy observed deposited epitope	2 sitesderived deposited sitePDB 6Y0F, 9DVR	View records Tier / rank Structure A · full reviewresource rank 9 Cell context StromalProvisional Transcript ContextCells with highest recorded RNA detection: fibroblast · 26.1% expressingCompare recorded cell populations Observed intervention evidence No normalized intervention action or modalityMeasured target-level compound records: 10Compound coverage: represented Molecular format scores Antibody Format Binder · 90/100 Miniprotein Binder · 85/100 Small Molecule · 83/100 Planning limits and missing evidence action unresolved in assigned intervention records candidate generation and promotion not in scope cell owner routing remains provisional transcript context
CD47T-ENSG00000196776	1 proposed task block observed immune receptor partner interface	1 sitederived deposited sitePDB 2JJS	View records Tier / rank Structure A · full reviewresource rank 10 Cell context ImmuneProvisional Transcript ContextCells with highest recorded RNA detection: macrophage group b · 43.8% expressingCompare recorded cell populations Observed intervention evidence No normalized intervention action or modalityMeasured target-level compound records: 5Compound coverage: represented Molecular format scores Miniprotein Binder · 85/100 Peptide Or Modified Peptide · 77/100 Antibody Format Binder · 75/100 Planning limits and missing evidence action unresolved in assigned intervention records candidate generation and promotion not in scope cell owner routing remains provisional transcript context
ITGB6T-ENSG00000115221	1 proposed task bind or occupy observed deposited epitope	1 sitesupplemental prepared site availablePDB 8TCG	View records Tier / rank Structure B · focused reviewresource rank 11 Cell context Malignant EpithelialProvisional Transcript ContextCells with highest recorded RNA detection: tumor · 8.5% expressingCompare recorded cell populations Observed intervention evidence No normalized intervention action or modalityCompound activity records: Not collected Molecular format scores Miniprotein Binder · 95/100 Peptide Or Modified Peptide · 77/100 Antibody Format Binder · 75/100 Planning limits and missing evidence action unresolved in assigned intervention records candidate generation and promotion not in scope cell owner routing remains provisional transcript context measured compound coverage not collected for this target tier
ITGAVT-ENSG00000138448	1 proposed task bind or occupy observed deposited epitope	1 sitesupplemental prepared site availablePDB 8TCG	View records Tier / rank Structure B · focused reviewresource rank 12 Cell context StromalProvisional Transcript ContextCells with highest recorded RNA detection: fibroblast · 39.4% expressingCompare recorded cell populations Observed intervention evidence No normalized intervention action or modalityCompound activity records: Not collected Molecular format scores Miniprotein Binder · 95/100 Peptide Or Modified Peptide · 77/100 Antibody Format Binder · 75/100 Planning limits and missing evidence action unresolved in assigned intervention records candidate generation and promotion not in scope cell owner routing remains provisional transcript context measured compound coverage not collected for this target tier
LGR5T-ENSG00000139292	1 proposed task map an extracellular binder site then test occupancy	Not assessed	View records Tier / rank Structure B · focused reviewresource rank 13 Cell context UnresolvedUnresolvedCompare recorded cell populations Observed intervention evidence No normalized intervention action or modalityCompound activity records: Not collected Molecular format scores Miniprotein Binder · 85/100 Peptide Or Modified Peptide · 77/100 Antibody Format Binder · 75/100 Planning limits and missing evidence action unresolved in assigned intervention records candidate generation and promotion not in scope cell owner context unresolved deposited site not evaluated or unavailable in current tier scope measured compound coverage not collected for this target tier
CDH17T-ENSG00000079112	1 proposed task map an extracellular binder site then test occupancy	Not assessed	View records Tier / rank Structure B · focused reviewresource rank 14 Cell context UnresolvedUnresolvedCompare recorded cell populations Observed intervention evidence car t cell therapy (3) Compound activity records: Not collected Molecular format scores Engineered Cell Therapy · 92/100 Miniprotein Binder · 90/100 Peptide Or Modified Peptide · 82/100 Planning limits and missing evidence action unresolved in assigned intervention records candidate generation and promotion not in scope cell owner context unresolved deposited site not evaluated or unavailable in current tier scope measured compound coverage not collected for this target tier
PDCD1T-ENSG00000188389	3 proposed tasks test target associated binding after site selection test target associated blockade after partner or site resolution test target associated inhibition after site and assay resolution	Not assessed	View records Tier / rank Structure B · focused reviewresource rank 15 Cell context UnresolvedUnresolvedCompare recorded cell populations Observed intervention evidence binder (3) blocker (2) inhibitor (4) antibody (13) bispecific antibody (2) conventional cytotoxic regimen (2) other or unclear (2) Compound activity records: Not collected Molecular format scores Antibody Format Binder · 85/100 Miniprotein Binder · 75/100 Engineered Cell Therapy · 67/100 Planning limits and missing evidence candidate generation and promotion not in scope cell owner context unresolved deposited site not evaluated or unavailable in current tier scope measured compound coverage not collected for this target tier
GPA33T-ENSG00000143167	1 proposed task evaluate target associated molecular imaging route	Not assessed	View records Tier / rank Structure B · focused reviewresource rank 16 Cell context UnresolvedUnresolvedCompare recorded cell populations Observed intervention evidence molecular imaging (2) molecular imaging agent (3) Compound activity records: Not collected Molecular format scores Antibody Format Binder · 80/100 Miniprotein Binder · 80/100 Peptide Or Modified Peptide · 72/100 Planning limits and missing evidence candidate generation and promotion not in scope cell owner context unresolved deposited site not evaluated or unavailable in current tier scope measured compound coverage not collected for this target tier
MUC1T-ENSG00000185499	1 proposed task map an extracellular binder site then test occupancy	Not assessed	View records Tier / rank Structure B · focused reviewresource rank 17 Cell context Malignant EpithelialProvisional Transcript ContextCells with highest recorded RNA detection: tumor · 30.7% expressingCompare recorded cell populations Observed intervention evidence car nk cell therapy (1) car t cell therapy (1) Compound activity records: Not collected Molecular format scores Engineered Cell Therapy · 87/100 Antibody Format Binder · 80/100 Miniprotein Binder · 80/100 Planning limits and missing evidence action unresolved in assigned intervention records candidate generation and promotion not in scope cell owner routing remains provisional transcript context deposited site not evaluated or unavailable in current tier scope measured compound coverage not collected for this target tier
CD274T-ENSG00000120217	3 proposed tasks test target associated binding after site selection test target associated blockade after partner or site resolution test target associated inhibition after site and assay resolution	Not assessed	View records Tier / rank Structure B · focused reviewresource rank 18 Cell context UnresolvedUnresolvedCompare recorded cell populations Observed intervention evidence binder (3) blocker (3) inhibitor (1) antibody (4) Compound activity records: Not collected Molecular format scores Antibody Format Binder · 85/100 Miniprotein Binder · 75/100 Engineered Cell Therapy · 67/100 Planning limits and missing evidence candidate generation and promotion not in scope cell owner context unresolved deposited site not evaluated or unavailable in current tier scope measured compound coverage not collected for this target tier
MSLNT-ENSG00000102854	1 proposed task map an extracellular binder site then test occupancy	Not assessed	View records Tier / rank Structure B · focused reviewresource rank 19 Cell context Malignant EpithelialProvisional Transcript ContextCells with highest recorded RNA detection: tumor · 21.4% expressingCompare recorded cell populations Observed intervention evidence car t cell therapy (3) Compound activity records: Not collected Molecular format scores Engineered Cell Therapy · 87/100 Antibody Format Binder · 75/100 Miniprotein Binder · 75/100 Planning limits and missing evidence action unresolved in assigned intervention records candidate generation and promotion not in scope cell owner routing remains provisional transcript context deposited site not evaluated or unavailable in current tier scope measured compound coverage not collected for this target tier
CEACAM6T-ENSG00000086548	1 proposed task map an extracellular binder site then test occupancy	Not assessed	View records Tier / rank Structure B · focused reviewresource rank 20 Cell context Malignant EpithelialProvisional Transcript ContextCells with highest recorded RNA detection: tumor · 38.8% expressingCompare recorded cell populations Observed intervention evidence No normalized intervention action or modalityCompound activity records: Not collected Molecular format scores Antibody Format Binder · 80/100 Miniprotein Binder · 80/100 Peptide Or Modified Peptide · 72/100 Planning limits and missing evidence action unresolved in assigned intervention records candidate generation and promotion not in scope cell owner routing remains provisional transcript context deposited site not evaluated or unavailable in current tier scope measured compound coverage not collected for this target tier
KDRT-ENSG00000128052	4 proposed tasks test target associated antagonism after site and assay resolution test target associated binding after site selection test target associated blockade after partner or site resolution test target associated inhibition after site and assay resolution	Not assessed	View records Tier / rank Structure B · focused reviewresource rank 21 Cell context EndothelialProvisional Transcript ContextCells with highest recorded RNA detection: endothelial · 40.6% expressingCompare recorded cell populations Observed intervention evidence antagonist (1) binder (1) blocker (1) inhibitor (2) antibody (2) small molecule (1) Compound activity records: Not collected Molecular format scores Antibody Format Binder · 85/100 Miniprotein Binder · 75/100 Engineered Cell Therapy · 67/100 Planning limits and missing evidence candidate generation and promotion not in scope cell owner routing remains provisional transcript context deposited site not evaluated or unavailable in current tier scope measured compound coverage not collected for this target tier
MUC13T-ENSG00000173702	1 proposed task map an extracellular binder site then test occupancy	Not assessed	View records Tier / rank Structure B · focused reviewresource rank 22 Cell context UnresolvedUnresolvedCompare recorded cell populations Observed intervention evidence No normalized intervention action or modalityCompound activity records: Not collected Molecular format scores Antibody Format Binder · 80/100 Miniprotein Binder · 80/100 Peptide Or Modified Peptide · 72/100 Planning limits and missing evidence action unresolved in assigned intervention records candidate generation and promotion not in scope cell owner context unresolved deposited site not evaluated or unavailable in current tier scope measured compound coverage not collected for this target tier
ERBB3T-ENSG00000065361	1 proposed task evaluate target associated payload delivery route	Not assessed	View records Tier / rank Structure B · focused reviewresource rank 23 Cell context Malignant EpithelialProvisional Transcript ContextCells with highest recorded RNA detection: tumor · 32.7% expressingCompare recorded cell populations Observed intervention evidence cytotoxic payload delivery (1) bispecific antibody drug conjugate (1) Compound activity records: Not collected Molecular format scores Antibody Drug Conjugate · 85/100 Antibody Format Binder · 85/100 Miniprotein Binder · 75/100 Planning limits and missing evidence candidate generation and promotion not in scope cell owner routing remains provisional transcript context deposited site not evaluated or unavailable in current tier scope measured compound coverage not collected for this target tier
PLAURT-ENSG00000011422	1 proposed task map an extracellular binder site then test occupancy	Not assessed	View records Tier / rank Structure B · focused reviewresource rank 24 Cell context ImmuneProvisional Transcript ContextCells with highest recorded RNA detection: macrophage group b · 50.9% expressingCompare recorded cell populations Observed intervention evidence No normalized intervention action or modalityCompound activity records: Not collected Molecular format scores Antibody Format Binder · 75/100 Miniprotein Binder · 75/100 Engineered Cell Therapy · 67/100 Planning limits and missing evidence action unresolved in assigned intervention records candidate generation and promotion not in scope cell owner routing remains provisional transcript context deposited site not evaluated or unavailable in current tier scope measured compound coverage not collected for this target tier
CLDN4T-ENSG00000189143	1 proposed task map an extracellular binder site then test occupancy	Not assessed	View records Tier / rank Structure B · focused reviewresource rank 25 Cell context Malignant EpithelialProvisional Transcript ContextCells with highest recorded RNA detection: tumor · 46.3% expressingCompare recorded cell populations Observed intervention evidence No normalized intervention action or modalityCompound activity records: Not collected Molecular format scores Antibody Format Binder · 80/100 Miniprotein Binder · 80/100 Peptide Or Modified Peptide · 72/100 Planning limits and missing evidence action unresolved in assigned intervention records candidate generation and promotion not in scope cell owner routing remains provisional transcript context deposited site not evaluated or unavailable in current tier scope measured compound coverage not collected for this target tier
EPHB2T-ENSG00000133216	1 proposed task map an extracellular binder site then test occupancy	Not assessed	View records Tier / rank Structure B · focused reviewresource rank 26 Cell context Malignant EpithelialProvisional Transcript ContextCells with highest recorded RNA detection: tumor · 15.9% expressingCompare recorded cell populations Observed intervention evidence No normalized intervention action or modalityCompound activity records: Not collected Molecular format scores Antibody Format Binder · 80/100 Miniprotein Binder · 80/100 Peptide Or Modified Peptide · 72/100 Planning limits and missing evidence action unresolved in assigned intervention records candidate generation and promotion not in scope cell owner routing remains provisional transcript context deposited site not evaluated or unavailable in current tier scope measured compound coverage not collected for this target tier
IGF1RT-ENSG00000140443	1 proposed task test target associated binding after site selection	Not assessed	View records Tier / rank Structure B · focused reviewresource rank 27 Cell context UnresolvedUnresolvedCompare recorded cell populations Observed intervention evidence binder (1) antibody (3) Compound activity records: Not collected Molecular format scores Antibody Format Binder · 85/100 Miniprotein Binder · 75/100 Engineered Cell Therapy · 67/100 Planning limits and missing evidence candidate generation and promotion not in scope cell owner context unresolved deposited site not evaluated or unavailable in current tier scope measured compound coverage not collected for this target tier
CLDN3T-ENSG00000165215	1 proposed task map an extracellular binder site then test occupancy	Not assessed	View records Tier / rank Structure B · focused reviewresource rank 28 Cell context Malignant EpithelialProvisional Transcript ContextCells with highest recorded RNA detection: tumor · 49.1% expressingCompare recorded cell populations Observed intervention evidence No normalized intervention action or modalityCompound activity records: Not collected Molecular format scores Antibody Format Binder · 80/100 Miniprotein Binder · 80/100 Peptide Or Modified Peptide · 72/100 Planning limits and missing evidence action unresolved in assigned intervention records candidate generation and promotion not in scope cell owner routing remains provisional transcript context deposited site not evaluated or unavailable in current tier scope measured compound coverage not collected for this target tier
CLDN7T-ENSG00000181885	1 proposed task map an extracellular binder site then test occupancy	Not assessed	View records Tier / rank Structure B · focused reviewresource rank 29 Cell context Malignant EpithelialProvisional Transcript ContextCells with highest recorded RNA detection: tumor · 48.2% expressingCompare recorded cell populations Observed intervention evidence No normalized intervention action or modalityCompound activity records: Not collected Molecular format scores Antibody Format Binder · 80/100 Miniprotein Binder · 80/100 Peptide Or Modified Peptide · 72/100 Planning limits and missing evidence action unresolved in assigned intervention records candidate generation and promotion not in scope cell owner routing remains provisional transcript context deposited site not evaluated or unavailable in current tier scope measured compound coverage not collected for this target tier
NCAM1T-ENSG00000149294	1 proposed task map an extracellular binder site then test occupancy	Not assessed	View records Tier / rank Structure B · focused reviewresource rank 30 Cell context UnresolvedUnresolvedCompare recorded cell populations Observed intervention evidence No normalized intervention action or modalityCompound activity records: Not collected Molecular format scores Antibody Format Binder · 75/100 Miniprotein Binder · 75/100 Engineered Cell Therapy · 67/100 Planning limits and missing evidence action unresolved in assigned intervention records candidate generation and promotion not in scope cell owner context unresolved deposited site not evaluated or unavailable in current tier scope measured compound coverage not collected for this target tier
TSPAN8T-ENSG00000127324	1 proposed task map an extracellular binder site then test occupancy	Not assessed	View records Tier / rank Structure C · best availableresource rank 31 Cell context Malignant EpithelialProvisional Transcript ContextCells with highest recorded RNA detection: tumor · 63.7% expressingCompare recorded cell populations Observed intervention evidence No normalized intervention action or modalityCompound activity records: Not collected Molecular format scores Antibody Format Binder · 80/100 Miniprotein Binder · 80/100 Peptide Or Modified Peptide · 72/100 Planning limits and missing evidence action unresolved in assigned intervention records candidate generation and promotion not in scope cell owner routing remains provisional transcript context deposited site not evaluated or unavailable in current tier scope measured compound coverage not collected for this target tier
CLDN18T-ENSG00000066405	1 proposed task map an extracellular binder site then test occupancy	Not assessed	View records Tier / rank Structure C · best availableresource rank 32 Cell context UnresolvedUnresolvedCompare recorded cell populations Observed intervention evidence No normalized intervention action or modalityCompound activity records: Not collected Molecular format scores Engineered Cell Therapy · 87/100 Antibody Format Binder · 75/100 Miniprotein Binder · 75/100 Planning limits and missing evidence action unresolved in assigned intervention records candidate generation and promotion not in scope cell owner context unresolved deposited site not evaluated or unavailable in current tier scope measured compound coverage not collected for this target tier
CD276T-ENSG00000103855	1 proposed task evaluate target associated payload delivery route	Not assessed	View records Tier / rank Structure C · best availableresource rank 33 Cell context StromalProvisional Transcript ContextCells with highest recorded RNA detection: fibroblast · 24.6% expressingCompare recorded cell populations Observed intervention evidence antibody drug conjugate (3) Compound activity records: Not collected Molecular format scores Antibody Drug Conjugate · 85/100 Antibody Format Binder · 85/100 Miniprotein Binder · 75/100 Planning limits and missing evidence action unresolved in assigned intervention records candidate generation and promotion not in scope cell owner routing remains provisional transcript context deposited site not evaluated or unavailable in current tier scope measured compound coverage not collected for this target tier
CDH1T-ENSG00000039068	1 proposed task map an extracellular binder site then test occupancy	Not assessed	View records Tier / rank Structure C · best availableresource rank 34 Cell context Malignant EpithelialProvisional Transcript ContextCells with highest recorded RNA detection: tumor · 34.2% expressingCompare recorded cell populations Observed intervention evidence No normalized intervention action or modalityCompound activity records: Not collected Molecular format scores Antibody Format Binder · 80/100 Miniprotein Binder · 80/100 Peptide Or Modified Peptide · 72/100 Planning limits and missing evidence action unresolved in assigned intervention records candidate generation and promotion not in scope cell owner routing remains provisional transcript context deposited site not evaluated or unavailable in current tier scope measured compound coverage not collected for this target tier
DDR1T-ENSG00000204580	1 proposed task map an extracellular binder site then test occupancy	Not assessed	View records Tier / rank Structure C · best availableresource rank 35 Cell context Malignant EpithelialProvisional Transcript ContextCells with highest recorded RNA detection: tumor · 24.9% expressingCompare recorded cell populations Observed intervention evidence No normalized intervention action or modalityCompound activity records: Not collected Molecular format scores Antibody Format Binder · 75/100 Miniprotein Binder · 75/100 Engineered Cell Therapy · 67/100 Planning limits and missing evidence action unresolved in assigned intervention records candidate generation and promotion not in scope cell owner routing remains provisional transcript context deposited site not evaluated or unavailable in current tier scope measured compound coverage not collected for this target tier
ADAM17T-ENSG00000151694	1 proposed task map an extracellular binder site then test occupancy	Not assessed	View records Tier / rank Structure C · best availableresource rank 36 Cell context UnresolvedUnresolvedCompare recorded cell populations Observed intervention evidence No normalized intervention action or modalityCompound activity records: Not collected Molecular format scores Antibody Format Binder · 75/100 Miniprotein Binder · 75/100 Engineered Cell Therapy · 67/100 Planning limits and missing evidence action unresolved in assigned intervention records candidate generation and promotion not in scope cell owner context unresolved deposited site not evaluated or unavailable in current tier scope measured compound coverage not collected for this target tier
CLDN1T-ENSG00000163347	1 proposed task map an extracellular binder site then test occupancy	Not assessed	View records Tier / rank Structure C · best availableresource rank 37 Cell context Malignant EpithelialProvisional Transcript ContextCells with highest recorded RNA detection: tumor · 14.7% expressingCompare recorded cell populations Observed intervention evidence No normalized intervention action or modalityCompound activity records: Not collected Molecular format scores Antibody Format Binder · 75/100 Miniprotein Binder · 75/100 Engineered Cell Therapy · 67/100 Planning limits and missing evidence action unresolved in assigned intervention records candidate generation and promotion not in scope cell owner routing remains provisional transcript context deposited site not evaluated or unavailable in current tier scope measured compound coverage not collected for this target tier
TPBGT-ENSG00000146242	1 proposed task map an extracellular binder site then test occupancy	Not assessed	View records Tier / rank Structure C · best availableresource rank 38 Cell context StromalProvisional Transcript ContextCells with highest recorded RNA detection: fibroblast · 30.1% expressingCompare recorded cell populations Observed intervention evidence No normalized intervention action or modalityCompound activity records: Not collected Molecular format scores Antibody Format Binder · 75/100 Miniprotein Binder · 75/100 Engineered Cell Therapy · 67/100 Planning limits and missing evidence action unresolved in assigned intervention records candidate generation and promotion not in scope cell owner routing remains provisional transcript context deposited site not evaluated or unavailable in current tier scope measured compound coverage not collected for this target tier
FGFR3T-ENSG00000068078	2 proposed tasks evaluate target associated molecular imaging route evaluate target associated radionuclide delivery route	Not assessed	View records Tier / rank Structure C · best availableresource rank 39 Cell context UnresolvedUnresolvedCompare recorded cell populations Observed intervention evidence antibody (1) molecular imaging agent (1) radioligand therapy (1) Compound activity records: Not collected Molecular format scores Antibody Format Binder · 85/100 Miniprotein Binder · 75/100 Radioligand Or Radioimmunotherapy · 75/100 Planning limits and missing evidence action unresolved in assigned intervention records candidate generation and promotion not in scope cell owner context unresolved deposited site not evaluated or unavailable in current tier scope measured compound coverage not collected for this target tier
ADAM10T-ENSG00000137845	1 proposed task map an extracellular binder site then test occupancy	Not assessed	View records Tier / rank Structure C · best availableresource rank 40 Cell context EndothelialProvisional Transcript ContextCells with highest recorded RNA detection: endothelial · 33.4% expressingCompare recorded cell populations Observed intervention evidence No normalized intervention action or modalityCompound activity records: Not collected Molecular format scores Antibody Format Binder · 75/100 Miniprotein Binder · 75/100 Engineered Cell Therapy · 67/100 Planning limits and missing evidence action unresolved in assigned intervention records candidate generation and promotion not in scope cell owner routing remains provisional transcript context deposited site not evaluated or unavailable in current tier scope measured compound coverage not collected for this target tier
ST14T-ENSG00000149418	1 proposed task map an extracellular binder site then test occupancy	Not assessed	View records Tier / rank Structure C · best availableresource rank 41 Cell context Malignant EpithelialProvisional Transcript ContextCells with highest recorded RNA detection: tumor · 32.5% expressingCompare recorded cell populations Observed intervention evidence No normalized intervention action or modalityCompound activity records: Not collected Molecular format scores Antibody Format Binder · 80/100 Miniprotein Binder · 80/100 Peptide Or Modified Peptide · 72/100 Planning limits and missing evidence action unresolved in assigned intervention records candidate generation and promotion not in scope cell owner routing remains provisional transcript context deposited site not evaluated or unavailable in current tier scope measured compound coverage not collected for this target tier
MMP14T-ENSG00000157227	1 proposed task map an extracellular binder site then test occupancy	Not assessed	View records Tier / rank Structure C · best availableresource rank 42 Cell context StromalProvisional Transcript ContextCells with highest recorded RNA detection: fibroblast · 48.7% expressingCompare recorded cell populations Observed intervention evidence No normalized intervention action or modalityCompound activity records: Not collected Molecular format scores Antibody Format Binder · 75/100 Miniprotein Binder · 75/100 Engineered Cell Therapy · 67/100 Planning limits and missing evidence action unresolved in assigned intervention records candidate generation and promotion not in scope cell owner routing remains provisional transcript context deposited site not evaluated or unavailable in current tier scope measured compound coverage not collected for this target tier
RNF43T-ENSG00000108375	1 proposed task map an extracellular binder site then test occupancy	Not assessed	View records Tier / rank Structure C · best availableresource rank 43 Cell context UnresolvedUnresolvedCompare recorded cell populations Observed intervention evidence No normalized intervention action or modalityCompound activity records: Not collected Molecular format scores Antibody Format Binder · 80/100 Miniprotein Binder · 80/100 Peptide Or Modified Peptide · 72/100 Planning limits and missing evidence action unresolved in assigned intervention records candidate generation and promotion not in scope cell owner context unresolved deposited site not evaluated or unavailable in current tier scope measured compound coverage not collected for this target tier
ENTPD1T-ENSG00000138185	1 proposed task map an extracellular binder site then test occupancy	Not assessed	View records Tier / rank Structure C · best availableresource rank 44 Cell context EndothelialProvisional Transcript ContextCells with highest recorded RNA detection: endothelial · 46.0% expressingCompare recorded cell populations Observed intervention evidence No normalized intervention action or modalityCompound activity records: Not collected Molecular format scores Antibody Format Binder · 75/100 Miniprotein Binder · 75/100 Engineered Cell Therapy · 67/100 Planning limits and missing evidence action unresolved in assigned intervention records candidate generation and promotion not in scope cell owner routing remains provisional transcript context deposited site not evaluated or unavailable in current tier scope measured compound coverage not collected for this target tier
ANTXR1T-ENSG00000169604	1 proposed task map an extracellular binder site then test occupancy	Not assessed	View records Tier / rank Structure C · best availableresource rank 45 Cell context StromalProvisional Transcript ContextCells with highest recorded RNA detection: fibroblast · 42.7% expressingCompare recorded cell populations Observed intervention evidence No normalized intervention action or modalityCompound activity records: Not collected Molecular format scores Antibody Format Binder · 75/100 Miniprotein Binder · 75/100 Engineered Cell Therapy · 67/100 Planning limits and missing evidence action unresolved in assigned intervention records candidate generation and promotion not in scope cell owner routing remains provisional transcript context deposited site not evaluated or unavailable in current tier scope measured compound coverage not collected for this target tier
EPHA2T-ENSG00000142627	1 proposed task map an extracellular binder site then test occupancy	Not assessed	View records Tier / rank Structure C · best availableresource rank 46 Cell context Malignant EpithelialProvisional Transcript ContextCells with highest recorded RNA detection: tumor · 16.8% expressingCompare recorded cell populations Observed intervention evidence No normalized intervention action or modalityCompound activity records: Not collected Molecular format scores Antibody Format Binder · 75/100 Miniprotein Binder · 75/100 Engineered Cell Therapy · 67/100 Planning limits and missing evidence action unresolved in assigned intervention records candidate generation and promotion not in scope cell owner routing remains provisional transcript context deposited site not evaluated or unavailable in current tier scope measured compound coverage not collected for this target tier
FLT1T-ENSG00000102755	1 proposed task map an extracellular binder site then test occupancy	Not assessed	View records Tier / rank Structure C · best availableresource rank 47 Cell context EndothelialProvisional Transcript ContextCells with highest recorded RNA detection: endothelial · 56.1% expressingCompare recorded cell populations Observed intervention evidence No normalized intervention action or modalityCompound activity records: Not collected Molecular format scores Antibody Format Binder · 75/100 Miniprotein Binder · 75/100 Engineered Cell Therapy · 67/100 Planning limits and missing evidence action unresolved in assigned intervention records candidate generation and promotion not in scope cell owner routing remains provisional transcript context deposited site not evaluated or unavailable in current tier scope measured compound coverage not collected for this target tier
ENGT-ENSG00000106991	1 proposed task map an extracellular binder site then test occupancy	Not assessed	View records Tier / rank Structure C · best availableresource rank 48 Cell context EndothelialProvisional Transcript ContextCells with highest recorded RNA detection: endothelial · 77.7% expressingCompare recorded cell populations Observed intervention evidence No normalized intervention action or modalityCompound activity records: Not collected Molecular format scores Antibody Format Binder · 75/100 Miniprotein Binder · 75/100 Engineered Cell Therapy · 67/100 Planning limits and missing evidence action unresolved in assigned intervention records candidate generation and promotion not in scope cell owner routing remains provisional transcript context deposited site not evaluated or unavailable in current tier scope measured compound coverage not collected for this target tier
CA9T-ENSG00000107159	1 proposed task map an extracellular binder site then test occupancy	Not assessed	View records Tier / rank Structure C · best availableresource rank 49 Cell context UnresolvedUnresolvedCompare recorded cell populations Observed intervention evidence No normalized intervention action or modalityCompound activity records: Not collected Molecular format scores Antibody Format Binder · 75/100 Miniprotein Binder · 75/100 Engineered Cell Therapy · 67/100 Planning limits and missing evidence action unresolved in assigned intervention records candidate generation and promotion not in scope cell owner context unresolved deposited site not evaluated or unavailable in current tier scope measured compound coverage not collected for this target tier
MST1RT-ENSG00000164078	1 proposed task map an extracellular binder site then test occupancy	Not assessed	View records Tier / rank Structure C · best availableresource rank 50 Cell context UnresolvedUnresolvedCompare recorded cell populations Observed intervention evidence No normalized intervention action or modalityCompound activity records: Not collected Molecular format scores Antibody Format Binder · 75/100 Miniprotein Binder · 75/100 Engineered Cell Therapy · 67/100 Planning limits and missing evidence action unresolved in assigned intervention records candidate generation and promotion not in scope cell owner context unresolved deposited site not evaluated or unavailable in current tier scope measured compound coverage not collected for this target tier

Planning counts

Tiered targets: 50
Targets with deposited sites: 12
Proposed tasks excluding site discovery: 52
Targets needing site discovery: 30
Measured compound records: 57
Unresolved determinant concepts: 6

Other cell-surface molecules and protein forms

This table lists searches for glycans, glycolipids, and protein variants. The literature matches provide leads for identifying the exact molecules.

Cell-surface molecule search results
Search concept	Molecule type	Possible carrier proteins	Literature matches	Review status	Next research step
tumor-associated MUC1 glycoformsD-CONCEPT-MUC1-GLYCOFORMS	protein glycoform concept	MUC1proposed carrier	14	unresolved	Resolve exact molecular identity, then review source evidence and extracellular display.
sialyl-TnD-CONCEPT-SIALYL-TN	glycan concept	No carrier candidate registered	15	unresolved	Resolve exact molecular identity, then review source evidence and extracellular display.
glycosylated CEACAM extracellular epitopesD-CONCEPT-CEACAM-GLYCOEPITOPES	protein family glycoepitope concept	CEACAM6proposed carrier CEACAM5proposed carrier	78	unresolved	Resolve exact molecular identity, then review source evidence and extracellular display.
colorectal tumor-associated gangliosidesD-CONCEPT-GANGLIOSIDES	glycolipid family concept	No carrier candidate registered	13	unresolved	Resolve exact molecular identity, then review source evidence and extracellular display.
surface splice neoepitopesD-CONCEPT-SPLICE-NEOEPITOPES	splice proteoform concept	No carrier candidate registered	44	unresolved	Resolve exact molecular identity, then review source evidence and extracellular display.
surface cleavage neoepitopesD-CONCEPT-CLEAVAGE-NEOEPITOPES	cleavage proteoform concept	No carrier candidate registered	24	unresolved	Resolve exact molecular identity, then review source evidence and extracellular display.

Download the planning records

The JSON files preserve source IDs, selection rules, evidence limits, and unresolved issues. Use the CSV files to compare targets, or open a target page for its supporting sources and structures.

Downloads:Target/action/modality JSON Target/action/modality CSV Extracellular determinants JSON Extracellular determinants CSV Science campaign handoff