TACSTD2

Tumor-associated calcium signal transducer 2. UniProt annotates extracellular residues 27–274.

Published binding interface

Structure 9PI9 records TACSTD2 in contact with sacituzumab Fab. Select the contact residues to inspect this interface.

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RNA expression by cell type

Percentage of cells with detected TACSTD2 RNA in the public colon adenocarcinoma cell groups.

Tumor cells19.4%

Endothelial cells7.4%

Dendritic cells4.6%

Macrophages (group B)3.0%

Fibroblasts3.0%

Macrophages (group A)2.2%

Regulatory T cells1.3%

Adipocytes0.6%

CD4 T cells0.5%

Granulocytes0.5%

Natural killer cells0.5%

CD8 T cells0.5%

B cells0.1%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 253. Source study · Measurements (JSON)

Inspect the molecular structure

Published reference structure

TROP2 with sacituzumab

Deposited structure 9PI9. TROP2 dimer bound by sacituzumab Fab.

PDB entry: 9PI9
Target ID: T-ENSG00000184292

sacituzumab Fab heavy chain · chains A, C (ribbon)
sacituzumab Fab light chain · chains B, D (ribbon)
TROP2 dimer · chains E, F (ribbon)

Download PNG · Download settings · Source coordinates (CIF)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000184292
UniProt accession: P09758
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 323
Sequence SHA-256: f337b2b4d3670cc9da5ce68671c1e4c1d5cbd6d6c9d04d0f76cffca42e43a1da

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Canonical amino-acid sequence

MARGPGLAPPPLRLPLLLLVLAAVTGHTAAQDNCTCPTNKMTVCSPDGPGGRCQCRALGSGMAVDCSTLTSKCLLLKARMSAPKNARTLVRPSEHALVDNDGLYDPDCDPEGRFKARQCNQTSVCWCVNSVGVRRTDKGDLSLRCDELVRTHHILIDLRHRPTAGAFNHSDLDAELRRLFRERYRLHPKFVAAVHYEQPTIQIELRQNTSQKAAGDVDIGDAAYYFERDIKGESLFQGRGGLDLRVRGEPLQVERTLIYYLDEIPPKFSMKRLTAGLIAVIVVVVVALVAGMAVLVITNRRKSGKYKKVEIKELGELRKEPSL

Sequence positions 1–323

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–26

Membrane-spanning segments

275–297 (Helical)

Source-annotated domains

27–274 (Extracellular); 298–323 (Cytoplasmic)

Source-annotated extracellular intervals

27–274

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
27	274	248	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 48435a564c770c931554dab25ce15095db7b14f5879eb7a37db90d5a6b1c71a2 Amino-acid sequence for this intervalHTAAQDNCTCPTNKMTVCSPDGPGGRCQCRALGSGMAVDCSTLTSKCLLLKARMSAPKNARTLVRPSEHALVDNDGLYDPDCDPEGRFKARQCNQTSVCWCVNSVGVRRTDKGDLSLRCDELVRTHHILIDLRHRPTAGAFNHSDLDAELRRLFRERYRLHPKFVAAVHYEQPTIQIELRQNTSQKAAGDVDIGDAAYYFERDIKGESLFQGRGGLDLRVRGEPLQVERTLIYYLDEIPPKFSMKRLT

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P09758

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subcellular_location: SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
transmembrane: TRANSMEM 275..297; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 27..274; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 298..323; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..26; /evidence="ECO:0000255"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Tumor-associated calcium signal transducer 2
Protein location: Transmembrane protein
Canonical sequence: P09758 · 323 amino acids
Extracellular region: UniProt annotates extracellular residues 27–274.

More structures and generated models

Structure snapshots

Expression in normal tissues

RNA specificity: Tissue enhanced
RNA distribution: Detected in many
RNA tissue-specific nTPM: esophagus: 1,245.4; salivary gland: 585.3; skin 1: 554.9
Protein specificity: Tissue enhanced
Protein distribution: Detected in many
Immunohistochemistry reliability: Enhanced
Immunofluorescence reliability: Supported
Protein tissue-specific intensity: lung: 22,139,708.2; salivary gland: 23,989,590.1
Tissue cell-type enrichment: Liver - Cholangiocytes, Pancreas - Ductal cells, Skin - Keratinocyte (other)
Subcellular location: Plasma membrane

Human Protein Atlas: TACSTD2

Structures

Structures records linked to TACSTD2.
Name	Stable ID	Action	Format	Status	Claim
9PI9	S-RCSB-9PI9	Not recorded	Not recorded	not recorded	verified deposited experimental structure

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

TACSTD2 · ENSG00000184292 · P09758