GPA33

Cell surface A33 antigen. UniProt annotates extracellular residues 22–235.

Predicted protein structure

A downloaded AlphaFold model connects the GPA33 sequence to its predicted three-dimensional structure.

RNA expression in tumor samples

Median GPA33 RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples4,585.1

Other tumor types438 samples4,215.3

Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000143167
UniProt accession: Q99795
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 319
Sequence SHA-256: 215f76c7b8f0b91d349f701c41d9d579dad822a42ccfb1031207b3ed85cc30c3

View and select the full canonical sequence

Canonical amino-acid sequence

MVGKMWPVLWTLCAVRVTVDAISVETPQDVLRASQGKSVTLPCTYHTSTSSREGLIQWDKLLLTHTERVVIWPFSNKNYIHGELYKNRVSISNNAEQSDASITIDQLTMADNGTYECSVSLMSDLEGNTKSRVRLLVLVPPSKPECGIEGETIIGNNIQLTCQSKEGSPTPQYSWKRYNILNQEQPLAQPASGQPVSLKNISTDTSGYYICTSSNEEGTQFCNITVAVRSPSMNVALYVGIAVGVVAALIIIGIIIYCCCCRGKDDNTEDKEDARPNREAYEEPPEQLRELSREREEEDDYRQEEQRSTGRESPDHLDQ

Sequence positions 1–319

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–21

Membrane-spanning segments

236–256 (Helical)

Source-annotated domains

22–235 (Extracellular); 257–319 (Cytoplasmic)

Source-annotated extracellular intervals

22–235

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
22	235	214	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 bd4695cbf88fde598ea52b854a31d1fdab19c9daa46214aec69141b3007cfafd Amino-acid sequence for this intervalISVETPQDVLRASQGKSVTLPCTYHTSTSSREGLIQWDKLLLTHTERVVIWPFSNKNYIHGELYKNRVSISNNAEQSDASITIDQLTMADNGTYECSVSLMSDLEGNTKSRVRLLVLVPPSKPECGIEGETIIGNNIQLTCQSKEGSPTPQYSWKRYNILNQEQPLAQPASGQPVSLKNISTDTSGYYICTSSNEEGTQFCNITVAVRSPSMNV

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: Q99795

Download source snapshot (gzip)

subcellular_location: SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
transmembrane: TRANSMEM 236..256; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 22..235; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 257..319; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..21
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Cell surface A33 antigen
Protein location: Transmembrane protein
Canonical sequence: Q99795 · 319 amino acids
Extracellular region: UniProt annotates extracellular residues 22–235.

Expression in normal tissues

RNA specificity: Tissue enriched
RNA distribution: Detected in some
RNA tissue-specific nTPM: intestine: 202.4
Protein specificity: Group enriched
Protein distribution: Detected in some
Immunohistochemistry reliability: Enhanced
Protein tissue-specific intensity: intestine: 3,797,648.3; lung: 12,369,590.6
Tissue cell-type enrichment: Colon - Colon enterocytes, Pituitary gland - Corticotropes, Testis - Early spermatids, Testis - Late spermatids

Human Protein Atlas: GPA33

Structures

A predicted target model is available.

Browse related molecular views

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

GPA33 · ENSG00000143167 · Q99795