PDCD1

Programmed cell death protein 1. UniProt annotates extracellular residues 25–170.

Predicted protein structure

A downloaded AlphaFold model connects the PDCD1 sequence to its predicted three-dimensional structure.

RNA expression in tumor samples

Median PDCD1 RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples25.0

Other tumor types438 samples22.0

Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000188389
UniProt accession: Q15116
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 288
Sequence SHA-256: c0f5745899a44e73098e606f4e09050e0b63f9b4f00cab49981806296b53d591

View and select the full canonical sequence

Canonical amino-acid sequence

MQIPQAPWPVVWAVLQLGWRPGWFLDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRVTERRAEVPTAHPSPSPRPAGQFQTLVVGVVGGLLGSLVLLVWVLAVICSRAARGTIGARRTGQPLKEDPSAVPVFSVDYGELDFQWREKTPEPPVPCVPEQTEYATIVFPSGMGTSSPARRGSADGPRSAQPLRPEDGHCSWPL

Sequence positions 1–288

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–24

Membrane-spanning segments

171–191 (Helical)

Source-annotated domains

25–170 (Extracellular); 192–288 (Cytoplasmic)

Source-annotated extracellular intervals

25–170

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
25	170	146	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 46bcac16aaaa6b413dccd5770407242c5b7c425735eb0524d2d401ca411115db Amino-acid sequence for this intervalLDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRVTERRAEVPTAHPSPSPRPAGQFQTLV

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: Q15116

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subcellular_location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:30487606, ECO:0000269|PubMed:31754127}; Single-pass type I membrane protein.
transmembrane: TRANSMEM 171..191; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 25..170; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 192..288; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..24; /evidence="ECO:0000255"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Programmed cell death protein 1
Protein location: Transmembrane protein
Canonical sequence: Q15116 · 288 amino acids
Extracellular region: UniProt annotates extracellular residues 25–170.

Expression in normal tissues

RNA specificity: Tissue enhanced
RNA distribution: Detected in some
RNA tissue-specific nTPM: heart muscle: 6.4; lymphoid tissue: 15.0
Protein specificity: Group enriched
Protein distribution: Detected in some
Immunohistochemistry reliability: Enhanced
Protein tissue-specific intensity: intestine: 3,400,884.9; lymphoid tissue: 3,303,614.0
Tissue cell-type enrichment: Adipose subcutaneous - T-cells, Adipose visceral - T-cells, Adrenal gland - T-cells, Colon - T-cells, Prostate - T-cells, Thyroid gland - T-cells

Human Protein Atlas: PDCD1

Structures

A predicted target model is available.

Browse related molecular views

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

PDCD1 · ENSG00000188389 · Q15116