CA9

Carbonic anhydrase 9. UniProt annotates extracellular residues 38–414.

Predicted protein structure

A downloaded AlphaFold model connects the CA9 sequence to its predicted three-dimensional structure.

RNA expression in tumor samples

Median CA9 RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples952.5

Other tumor types438 samples282.5

Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

Choose a protein region, search amino-acid letters, or inspect a recorded binding site.

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000107159
UniProt accession: Q16790
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 459
Sequence SHA-256: 3501ff1a2c34e139907d0b8726e0ce2d830cfc7304472a862525f3428a6a534c

View and select the full canonical sequence

Canonical amino-acid sequence

MAPLCPSPWLPLLIPAPAPGLTVQLLLSLLLLVPVHPQRLPRMQEDSPLGGGSSGEDDPLGEEDLPSEEDSPREEDPPGEEDLPGEEDLPGEEDLPEVKPKSEEEGSLKLEDLPTVEAPGDPQEPQNNAHRDKEGDDQSHWRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPLELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLWGPGDSRLQLNFRATQPLNGRVIEASFPAGVDSSPRAAEPVQLNSCLAAGDILALVFGLLFAVTSVAFLVQMRRQHRRGTKGGVSYRPAEVAETGA

Sequence positions 1–459

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–37

Membrane-spanning segments

415–435 (Helical)

Source-annotated domains

38–414 (Extracellular); 436–459 (Cytoplasmic)

Source-annotated extracellular intervals

38–414

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
38	414	377	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 2c27afc7e5425ff38eb960c66408c91e5d0a4b9c8f252786527e17026b7a597c Amino-acid sequence for this intervalQRLPRMQEDSPLGGGSSGEDDPLGEEDLPSEEDSPREEDPPGEEDLPGEEDLPGEEDLPEVKPKSEEEGSLKLEDLPTVEAPGDPQEPQNNAHRDKEGDDQSHWRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPLELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLWGPGDSRLQLNFRATQPLNGRVIEASFPAGVDSSPRAAEPVQLNSCLAAGD

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

Download source snapshot

Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: Q16790

Download source snapshot (gzip)

subcellular_location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8486430}. Nucleus, nucleolus {ECO:0000269|PubMed:8486430}. Cell membrane {ECO:0000269|PubMed:8486430}; Single-pass type I membrane protein {ECO:0000269|PubMed:8486430}. Cell projection, microvillus membrane {ECO:0000269|PubMed:8486430}; Single-pass type I membrane protein {ECO:0000269|PubMed:8486430}. Note=Found on the surface microvilli and in the nucleus, particularly in nucleolus.
transmembrane: TRANSMEM 415..435; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 38..414; /note="Extracellular"; TOPO_DOM 436..459; /note="Cytoplasmic"
signal_peptide: SIGNAL 1..37; /evidence="ECO:0000269|PubMed:15340161"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Carbonic anhydrase 9
Protein location: Transmembrane protein
Canonical sequence: Q16790 · 459 amino acids
Extracellular region: UniProt annotates extracellular residues 38–414.

Expression in normal tissues

RNA specificity: Tissue enriched
RNA distribution: Detected in some
RNA tissue-specific nTPM: stomach 1: 293.9
Protein specificity: Tissue enriched
Protein distribution: Detected in some
Immunohistochemistry reliability: Enhanced
Immunofluorescence reliability: Supported
Protein tissue-specific intensity: Stomach: 282,652,562.9
Tissue cell-type enrichment: Adipose visceral - Mesothelial cells, Liver - Cholangiocytes, Prostate - Smooth muscle cells, Testis - Late spermatids
Subcellular location: Plasma membrane

Human Protein Atlas: CA9

Structures

A predicted target model is available.

Browse related molecular views

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

CA9 · ENSG00000107159 · Q16790