LGR5

Leucine-rich repeat-containing G protein-coupled receptor 5. UniProt annotates extracellular residues 22–561, 615–638, 704–722, 789–802.

Published structure

Inspect the deposited LGR5 structure and its molecular partners.

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RNA expression in tumor samples

Median LGR5 RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples744.6

Other tumor types438 samples1,335.2

Compare the sample groups · cBioPortal measurements (JSON)

Inspect the molecular structure

Published reference structure

LGR5 with R-spondin-1

Deposited structure 4BSU. LGR5 ectodomain bound by R-spondin-1 Fu1-Fu2.

PDB entry: 4BSU
Target ID: T-ENSG00000139292

LGR5 ectodomain · chains A, B, E, F (ribbon)
R-spondin-1 Fu1-Fu2 · chains C, D, G, H (ribbon)

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Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000139292
UniProt accession: O75473
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 907
Sequence SHA-256: cc3dde6315d01a901a70da9905ad6066dbe3581d2a9c572151cc72773b62f0be

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Canonical amino-acid sequence

MDTSRLGVLLSLPVLLQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSLISSENFPELKVIEMPYAYQCCAFGVCENAYKISNQWNKGDNSSMDDLHKKDAGMFQAQDERDLEDFLLDFEEDLKALHSVQCSPSPGPFKPCEHLLDGWLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGCHVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPFGEPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGDLENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFISPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDLVSLRKQTYVWTRSKHPSLMSINSDDVEKQSCDSTQALVTFTSSSITYDLPPSSVPSPAYPVTESCHLSSVAFVPCL

Sequence positions 1–907

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–21

Membrane-spanning segments

562–582 (Helical; Name=1); 594–614 (Helical; Name=2); 639–659 (Helical; Name=3); 683–703 (Helical; Name=4); 723–743 (Helical; Name=5); 768–788 (Helical; Name=6); 803–823 (Helical; Name=7)

Source-annotated domains

22–561 (Extracellular); 583–593 (Cytoplasmic); 615–638 (Extracellular); 660–682 (Cytoplasmic); 704–722 (Extracellular); 744–767 (Cytoplasmic); 789–802 (Extracellular); 824–907 (Cytoplasmic)

Source-annotated extracellular intervals

22–561; 615–638; 704–722; 789–802

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
22	561	540	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 e0a63bd67c09dcb7251fd896dc10acf73c9eafc0d198d1e6da305041f2b5dcc5 Amino-acid sequence for this intervalGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSLISSENFPELKVIEMPYAYQCCAFGVCENAYKISNQWNKGDNSSMDDLHKKDAGMFQAQDERDLEDFLLDFEEDLKALHSVQCSPSPGPFKPCEHLLDGWLIR
615	638	24	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 f980a188d3a8f575a6e5380c0a9bfd9219953d1ba5ba4c01b28e93f8427a0964 Amino-acid sequence for this intervalGVDAFTFGSFARHGAWWENGVGCH
704	722	19	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 4601ca6ca1a10a9b5da05e3fcbe782dc6ee24fa28859ec52a7025e7ae7bebba8 Amino-acid sequence for this intervalSKYGASPLCLPLPFGEPST
789	802	14	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 8aa1556b199718ab343bdb3c5cd87212aa56dfcd37d72a3804e9f92ce10136de Amino-acid sequence for this intervalSLINLTFISPEVIK

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: O75473

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subcellular_location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Rapidly and constitutively internalized to the trans-Golgi network at steady state. Internalization to the trans-Golgi network may be the result of phosphorylation at Ser-861 and Ser-864; however, the phosphorylation event has not been proven (PubMed:23439653). {ECO:0000269|PubMed:23439653}.
transmembrane: TRANSMEM 562..582; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 594..614; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 639..659; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 683..703; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 723..743; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 768..788; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 803..823; /note="Helical; Name=7"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 22..561; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 583..593; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 615..638; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 660..682; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 704..722; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 744..767; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 789..802; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 824..907; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..21; /evidence="ECO:0000255"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Leucine-rich repeat-containing G protein-coupled receptor 5
Protein location: Transmembrane protein
Canonical sequence: O75473 · 907 amino acids
Extracellular region: UniProt annotates extracellular residues 22–561, 615–638, 704–722, 789–802.

More structures and generated models

Structure snapshots

Expression in normal tissues

RNA specificity: Tissue enhanced
RNA distribution: Detected in many
RNA tissue-specific nTPM: fallopian tube: 15.9; placenta: 17.9; skeletal muscle: 21.2
Protein specificity: Not detected
Protein distribution: Not detected
Immunohistochemistry reliability: Approved
Immunofluorescence reliability: Approved
Tissue cell-type enrichment: Adrenal gland - Adrenal cortex cells, Skin - Hair cortex cells, Skin - Inner root sheath cells, Skin - Outer root sheath cells
Subcellular location: Nucleoplasm, Vesicles, Primary cilium transition zone

Human Protein Atlas: LGR5

Structures

Structures records linked to LGR5.
Name	Stable ID	Action	Format	Status	Claim
4BSU	S-RCSB-4BSU	Not recorded	Not recorded	not recorded	verified deposited experimental structure

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

LGR5 · ENSG00000139292 · O75473