MUC13

Mucin-13. UniProt annotates extracellular residues 19–421.

Predicted protein structure

A downloaded AlphaFold model connects the MUC13 sequence to its predicted three-dimensional structure.

RNA expression in tumor samples

Median MUC13 RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples12,911.8

Other tumor types438 samples11,494.6

Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

Choose a protein region, search amino-acid letters, or inspect a recorded binding site.

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000173702
UniProt accession: Q9H3R2
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 512
Sequence SHA-256: 6ccdfe078e8887becb02b25de1cc888d236aa8335ae3559acb65bbc51e791098

View and select the full canonical sequence

Canonical amino-acid sequence

MKAIIHLTLLALLSVNTATNQGNSADAVTTTETATSGPTVAAADTTETNFPETASTTANTPSFPTATSPAPPIISTHSSSTIPTPAPPIISTHSSSTIPIPTAADSESTTNVNSLATSDIITASSPNDGLITMVPSETQSNNEMSPTTEDNQSSGPPTGTALLETSTLNSTGPSNPCQDDPCADNSLCVKLHNTSFCLCLEGYYYNSSTCKKGKVFPGKISVTVSETFDPEEKHSMAYQDLHSEITSLFKDVFGTSVYGQTVILTVSTSLSPRSEMRADDKFVNVTIVTILAETTSDNEKTVTEKINKAIRSSSSNFLNYDLTLRCDYYGCNQTADDCLNGLACDCKSDLQRPNPQSPFCVASSLKCPDACNAQHKQCLIKKSGGAPECACVPGYQEDANGNCQKCAFGYSGLDCKDKFQLILTIVGTIAGIVILSMIIALIVTARSNNKTKHIEEENLIDEDFQNLKLRSTGFTNLGAEGSVFPKVRITASRDSQMQNPYSRHSSMPRPDY

Sequence positions 1–512

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–18

Membrane-spanning segments

422–442 (Helical)

Source-annotated domains

19–421 (Extracellular); 443–512 (Cytoplasmic)

Source-annotated extracellular intervals

19–421

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
19	421	403	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 89e54a0cc8d582309d7757d0f7ff0fb3886b566eb866c9450b0e9513514dac54 Amino-acid sequence for this intervalTNQGNSADAVTTTETATSGPTVAAADTTETNFPETASTTANTPSFPTATSPAPPIISTHSSSTIPTPAPPIISTHSSSTIPIPTAADSESTTNVNSLATSDIITASSPNDGLITMVPSETQSNNEMSPTTEDNQSSGPPTGTALLETSTLNSTGPSNPCQDDPCADNSLCVKLHNTSFCLCLEGYYYNSSTCKKGKVFPGKISVTVSETFDPEEKHSMAYQDLHSEITSLFKDVFGTSVYGQTVILTVSTSLSPRSEMRADDKFVNVTIVTILAETTSDNEKTVTEKINKAIRSSSSNFLNYDLTLRCDYYGCNQTADDCLNGLACDCKSDLQRPNPQSPFCVASSLKCPDACNAQHKQCLIKKSGGAPECACVPGYQEDANGNCQKCAFGYSGLDCKDKFQL

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

Download source snapshot

Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: Q9H3R2

Download source snapshot (gzip)

subcellular_location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11278439}; Single-pass type I membrane protein {ECO:0000269|PubMed:11278439}. Apical cell membrane {ECO:0000269|PubMed:11278439}. Secreted {ECO:0000269|PubMed:11278439}. Note=Also exists as a soluble form.
transmembrane: TRANSMEM 422..442; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 19..421; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 443..512; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..18; /evidence="ECO:0000255"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Mucin-13
Protein location: Transmembrane protein
Canonical sequence: Q9H3R2 · 512 amino acids
Extracellular region: UniProt annotates extracellular residues 19–421.

Expression in normal tissues

RNA specificity: Tissue enriched
RNA distribution: Detected in some
RNA tissue-specific nTPM: intestine: 579.0
Protein specificity: Tissue enriched
Protein distribution: Detected in many
Immunohistochemistry reliability: Enhanced
Protein tissue-specific intensity: kidney: 34,736,413.9
Tissue cell-type enrichment: Colon - Colon enterocytes, Kidney - Proximal tubular cells, Stomach - Gastric mucous cells

Human Protein Atlas: MUC13

Structures

A predicted target model is available.

Browse related molecular views

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

MUC13 · ENSG00000173702 · Q9H3R2