CLDN7

Claudin-7. UniProt annotates extracellular residues 29–81, 139–160.

Predicted protein structure

A downloaded AlphaFold model connects the CLDN7 sequence to its predicted three-dimensional structure.

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RNA expression by cell type

Percentage of cells with detected CLDN7 RNA in the public colon adenocarcinoma cell groups.

Tumor cells48.2%

Macrophages (group B)14.3%

Fibroblasts7.6%

Dendritic cells7.2%

Natural killer cells7.1%

Endothelial cells6.4%

Macrophages (group A)5.7%

Regulatory T cells4.9%

CD4 T cells3.7%

B cells3.6%

Granulocytes3.6%

CD8 T cells3.5%

Adipocytes3.4%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 247. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000181885
UniProt accession: O95471
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 211
Sequence SHA-256: 4f83f5437022a2c7e7495ac78debcd29017fbed519d1d99c2e7513b34bbfa952

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Canonical amino-acid sequence

MANSGLQLLGFSMALLGWVGLVACTAIPQWQMSSYAGDNIITAQAMYKGLWMDCVTQSTGMMSCKMYDSVLALSAALQATRALMVVSLVLGFLAMFVATMGMKCTRCGGDDKVKKARIAMGGGIIFIVAGLAALVACSWYGHQIVTDFYNPLIPTNIKYEFGPAIFIGWAGSALVILGGALLSCSCPGNESKAGYRVPRSYPKSNSSKEYV

Sequence positions 1–211

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Membrane-spanning segments

8–28 (Helical); 82–102 (Helical); 118–138 (Helical); 161–181 (Helical)

Source-annotated domains

1–7 (Cytoplasmic); 29–81 (Extracellular); 103–117 (Cytoplasmic); 139–160 (Extracellular); 182–211 (Cytoplasmic)

Source-annotated extracellular intervals

29–81; 139–160

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
29	81	53	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 11f0172278fd8c6aa45c5b75c9a0faf21a206df346d599fb8aa659cc7d985177 Amino-acid sequence for this intervalQWQMSSYAGDNIITAQAMYKGLWMDCVTQSTGMMSCKMYDSVLALSAALQATR
139	160	22	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 1fee64418878a9e6699d1d2070e469ef1d03745183e545362d25d43fef02e4a9 Amino-acid sequence for this intervalWYGHQIVTDFYNPLIPTNIKYE

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: O95471

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subcellular_location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12673207, ECO:0000269|PubMed:14502431, ECO:0000269|PubMed:20375010}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:16054130}. Cell junction, tight junction {ECO:0000269|PubMed:16054130}. Note=Co-localizes with EPCAM at the basolateral cell membrane and tight junction. {ECO:0000269|PubMed:16054130}.
transmembrane: TRANSMEM 8..28; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 82..102; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 118..138; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 161..181; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 1..7; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 29..81; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 103..117; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 139..160; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 182..211; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: Not recorded
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Claudin-7
Protein location: Transmembrane protein
Canonical sequence: O95471 · 211 amino acids
Extracellular region: UniProt annotates extracellular residues 29–81, 139–160.

Expression in normal tissues

RNA specificity: Tissue enhanced
RNA distribution: Detected in many
RNA tissue-specific nTPM: esophagus: 324.6; intestine: 321.6
Protein specificity: Not detected
Protein distribution: Not detected
Immunohistochemistry reliability: Enhanced
Immunofluorescence reliability: Approved
Tissue cell-type enrichment: Breast - Breast glandular cells, Colon - Colon enterocytes, Lung - Alveolar cells type 2, Pancreas - Ductal cells, Skin - Eccrine sweat gland cells
Subcellular location: Vesicles

Human Protein Atlas: CLDN7

Structures

A predicted target model is available.

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Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

CLDN7 · ENSG00000181885 · O95471