FLT1

Vascular endothelial growth factor receptor 1. UniProt annotates extracellular residues 27–758.

Predicted protein structure

A downloaded AlphaFold model connects the FLT1 sequence to its predicted three-dimensional structure.

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RNA expression by cell type

Percentage of cells with detected FLT1 RNA in the public colon adenocarcinoma cell groups.

Endothelial cells56.1%

Adipocytes5.0%

Macrophages (group B)4.1%

Macrophages (group A)3.6%

Fibroblasts1.7%

Regulatory T cells0.9%

CD8 T cells0.6%

Tumor cells0.6%

CD4 T cells0.5%

B cells0.5%

Granulocytes0.3%

Dendritic cells0.0%

Natural killer cells0.0%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 52. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000102755
UniProt accession: P17948
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 1338
Sequence SHA-256: cabcd0382ed2f6481aa338d4235c57b559cc4d1a254f9c9aae6c341230ecaa90

View and select the full canonical sequence

Canonical amino-acid sequence

MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHKWSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPGIILGPGSSTLFIERVTEEDEGVYHCKATNQKGSVESSAYLTVQGTSDKSNLELITLTCTCVAATLFWLLLTLFIRKMKRSSSEIKTDYLSIIMDPDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGDLLQANVQQDGKDYIPINAILTGNSGFTYSTPAFSEDFFKESISAPKFNSGSSDDVRYVNAFKFMSLERIKTFEELLPNATSMFDDYQGDSSTLLASPMLKRFTWTDSKPKASLKIDLRVTSKSKESGLSDVSRPSFCHSSCGHVSEGKRRFTYDHAELERKIACCSPPPDYNSVVLYSTPPI

Sequence positions 1–1338

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–26

Membrane-spanning segments

759–780 (Helical)

Source-annotated domains

27–758 (Extracellular); 781–1338 (Cytoplasmic)

Source-annotated extracellular intervals

27–758

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
27	758	732	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 e21e3922dc5581205ab7c4e340cf5245f74ba3fd14dcb63f2e72728603448a45 Amino-acid sequence for this intervalSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHKWSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPGIILGPGSSTLFIERVTEEDEGVYHCKATNQKGSVESSAYLTVQGTSDKSNLE

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P17948

Download source snapshot (gzip)

subcellular_location: SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Endosome. Note=Autophosphorylation promotes ubiquitination and endocytosis.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:8248162}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted.; SUBCELLULAR LOCATION: [Isoform 4]: Secreted.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 6]: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 7]: Cytoplasm {ECO:0000305}.
transmembrane: TRANSMEM 759..780; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 27..758; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 781..1338; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..26; /evidence="ECO:0000269|PubMed:8248162"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Vascular endothelial growth factor receptor 1
Protein location: Transmembrane protein
Canonical sequence: P17948 · 1,338 amino acids
Extracellular region: UniProt annotates extracellular residues 27–758.

Expression in normal tissues

RNA specificity: Tissue enriched
RNA distribution: Detected in many
RNA tissue-specific nTPM: placenta: 394.3
Protein specificity: Tissue enriched
Protein distribution: Detected in single
Immunohistochemistry reliability: Enhanced
Immunofluorescence reliability: Supported
Protein tissue-specific intensity: skeletal muscle: 160,212.6
Tissue cell-type enrichment: Adipose visceral - Endothelial cells, Breast - Endothelial cells, Colon - Endothelial cells, Heart muscle - Endothelial cells, Liver - Vascular endothelial cells, Minor Salivary Gland - Endothelial cells, Pituitary gland - Endothelial cells, Prostate - Endothelial cells, Skin - Endothelial cells, Testis - Early spermatids
Subcellular location: Plasma membrane

Human Protein Atlas: FLT1

Structures

A predicted target model is available.

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Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

FLT1 · ENSG00000102755 · P17948