FGFR3

Fibroblast growth factor receptor 3. UniProt annotates extracellular residues 23–375.

Predicted protein structure

A downloaded AlphaFold model connects the FGFR3 sequence to its predicted three-dimensional structure.

RNA expression in tumor samples

Median FGFR3 RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples439.9

Other tumor types438 samples560.4

Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

Choose a protein region, search amino-acid letters, or inspect a recorded binding site.

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000068078
UniProt accession: P22607
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 806
Sequence SHA-256: 9c4089da85ef3c06dde2c14def7afc4a2e1452947ca9abf34025f90a101db770

View and select the full canonical sequence

Canonical amino-acid sequence

MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT

Sequence positions 1–806

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–22

Membrane-spanning segments

376–396 (Helical)

Source-annotated domains

23–375 (Extracellular); 397–806 (Cytoplasmic)

Source-annotated extracellular intervals

23–375

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
23	375	353	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 c315603c1c3eb07210c42b52fdae720ee3146eab601fadeefeb03781cee3ad4e Amino-acid sequence for this intervalESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAG

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P22607

Download source snapshot (gzip)

subcellular_location: SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle. Endoplasmic reticulum. Note=The activated receptor is rapidly internalized and degraded. Detected in intracellular vesicles after internalization of the autophosphorylated receptor.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
transmembrane: TRANSMEM 376..396; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 23..375; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 397..806; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..22
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Fibroblast growth factor receptor 3
Protein location: Transmembrane protein
Canonical sequence: P22607 · 806 amino acids
Extracellular region: UniProt annotates extracellular residues 23–375.

Expression in normal tissues

RNA specificity: Tissue enhanced
RNA distribution: Detected in many
RNA tissue-specific nTPM: brain: 148.8; esophagus: 126.6; skin 1: 256.5
Protein specificity: Tissue enriched
Protein distribution: Detected in single
Immunohistochemistry reliability: Enhanced
Immunofluorescence reliability: Supported
Protein tissue-specific intensity: cerebral cortex: 5,047,327.3
Tissue cell-type enrichment: Minor Salivary Gland - Minor salivary gland basal cells, Pituitary gland - Corticotropes, Prostate - Urothelial cells, Testis - Spermatogonia
Subcellular location: Endoplasmic reticulum

Human Protein Atlas: FGFR3

Structures

A predicted target model is available.

Browse related molecular views

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

FGFR3 · ENSG00000068078 · P22607