TPBG

Trophoblast glycoprotein. UniProt annotates extracellular residues 32–355.

Predicted protein structure

A downloaded AlphaFold model connects the TPBG sequence to its predicted three-dimensional structure.

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RNA expression by cell type

Percentage of cells with detected TPBG RNA in the public colon adenocarcinoma cell groups.

Fibroblasts30.1%

Endothelial cells13.8%

Tumor cells9.3%

Adipocytes8.9%

Macrophages (group B)1.8%

Macrophages (group A)0.9%

CD4 T cells0.9%

Dendritic cells0.7%

Granulocytes0.5%

CD8 T cells0.3%

B cells0.3%

Regulatory T cells0.3%

Natural killer cells0.0%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 665. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000146242
UniProt accession: Q13641
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 420
Sequence SHA-256: 51681f2cee5b5729bdc190698020665dfc2e9e327a0f5ada6907865092d8e114

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Canonical amino-acid sequence

MPGGCSRGPAAGDGRLRLARLALVLLGWVSSSSPTSSASSFSSSAPFLASAVSAQPPLPDQCPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPLVELILNHIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQLPSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHIRVFLDNNPWVCDCHMADMVTWLKETEVVQGKDRLTCAYPEKMRNRVLLELNSADLDCDPILPPSLQTSYVFLGIVLALIGAIFLLVLYLNRKGIKKWMHNIRDACRDHMEGYHYRYEINADPRLTNLSSNSDV

Sequence positions 1–420

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–31

Membrane-spanning segments

356–376 (Helical)

Source-annotated domains

32–355 (Extracellular); 377–420 (Cytoplasmic)

Source-annotated extracellular intervals

32–355

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
32	355	324	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 bd19613343b2c8e870d82f6d55cc0d34539d5dd7a4e5e30faf0ef571147274a5 Amino-acid sequence for this intervalSSPTSSASSFSSSAPFLASAVSAQPPLPDQCPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPLVELILNHIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQLPSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHIRVFLDNNPWVCDCHMADMVTWLKETEVVQGKDRLTCAYPEKMRNRVLLELNSADLDCDPILPPSLQTS

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: Q13641

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subcellular_location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24582434}; Single-pass type I membrane protein {ECO:0000269|PubMed:24582434}.
transmembrane: TRANSMEM 356..376; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 32..355; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 377..420; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..31; /evidence="ECO:0000255"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Trophoblast glycoprotein
Protein location: Transmembrane protein
Canonical sequence: Q13641 · 420 amino acids
Extracellular region: UniProt annotates extracellular residues 32–355.

Expression in normal tissues

RNA specificity: Low tissue specificity
RNA distribution: Detected in many
Protein specificity: Tissue enriched
Protein distribution: Detected in many
Immunohistochemistry reliability: Enhanced
Immunofluorescence reliability: Approved
Protein tissue-specific intensity: intestine: 23,141,939.1
Tissue cell-type enrichment: Adrenal gland - Fibroblasts, Breast - Breast glandular cells, Heart muscle - Fibroblasts, Lung - Fibroblasts_2
Subcellular location: Nucleoplasm

Human Protein Atlas: TPBG

Structures

A predicted target model is available.

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Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

TPBG · ENSG00000146242 · Q13641