ERBB2

Receptor tyrosine-protein kinase erbB-2. UniProt annotates extracellular residues 23–652.

Published binding interface

Structure 1N8Z records ERBB2 in contact with trastuzumab Fab. Select the contact residues to inspect this interface.

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RNA expression by cell type

Percentage of cells with detected ERBB2 RNA in the public colon adenocarcinoma cell groups.

Tumor cells21.7%

Fibroblasts12.6%

Adipocytes6.6%

Endothelial cells3.7%

Dendritic cells3.3%

Natural killer cells2.9%

Macrophages (group B)1.8%

Granulocytes1.4%

CD8 T cells1.0%

CD4 T cells0.8%

Macrophages (group A)0.8%

B cells0.8%

Regulatory T cells0.7%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 8. Source study · Measurements (JSON)

Inspect the molecular structure

Published reference structure

ERBB2 with trastuzumab

Deposited structure 1N8Z. ERBB2 extracellular domain bound by trastuzumab Fab.

PDB entry: 1N8Z
Target ID: T-ENSG00000141736

trastuzumab Fab light chain · chain A (ribbon)
trastuzumab Fab heavy chain · chain B (ribbon)
ERBB2 extracellular domain · chain C (ribbon)

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Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000141736
UniProt accession: P04626
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 1255
Sequence SHA-256: a5f256fc653515d110f6dd48ad55b8ea21bf6d45af33b7f5c182c6c31455b636

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Canonical amino-acid sequence

MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV

Sequence positions 1–1255

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–22

Membrane-spanning segments

653–675 (Helical)

Source-annotated domains

23–652 (Extracellular); 676–1255 (Cytoplasmic)

Source-annotated extracellular intervals

23–652

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
23	652	630	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 a1f6b928de9224f7c36c0321f82b1837333fab03ac7accebc06b41b8f7885ae3 Amino-acid sequence for this intervalTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLT

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P04626

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subcellular_location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:32381043}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, ruffle membrane {ECO:0000269|PubMed:34380438}; Single-pass type I membrane protein {ECO:0000255}. Note=Internalized from the cell membrane in response to EGF stimulation. {ECO:0000269|PubMed:32381043}.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:31138794, ECO:0000269|PubMed:33497358}; Single-pass type I membrane protein {ECO:0000255}. Early endosome {ECO:0000269|PubMed:31138794}. Cytoplasm, perinuclear region. Nucleus. Note=Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1. Also detected in VPS35-positive endosome-to-TGN retrograde vesicles (PubMed:31138794). {ECO:0000269|PubMed:31138794}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Nucleus.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm. Nucleus.
transmembrane: TRANSMEM 653..675; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 23..652; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 676..1255; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..22; /evidence="ECO:0000255"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Receptor tyrosine-protein kinase erbB-2
Protein location: Transmembrane protein
Canonical sequence: P04626 · 1,255 amino acids
Extracellular region: UniProt annotates extracellular residues 23–652.

More structures and generated models

Structure snapshots

Expression in normal tissues

RNA specificity: Low tissue specificity
RNA distribution: Detected in all
Protein specificity: Tissue enriched
Protein distribution: Detected in many
Immunohistochemistry reliability: Enhanced
Immunofluorescence reliability: Enhanced
Protein tissue-specific intensity: lymphoid tissue: 8,296,603.9
Tissue cell-type enrichment: Adrenal gland - Fibroblasts, Breast - Breast glandular cells, Lung - Alveolar cells type 1, Pituitary gland - Undifferentiated cells (Pituitary gland), Spleen - Fibroblasts_1
Subcellular location: Plasma membrane

Human Protein Atlas: ERBB2

Structures

Structures records linked to ERBB2.
Name	Stable ID	Action	Format	Status	Claim
1N8Z	S-RCSB-1N8Z	Not recorded	Not recorded	not recorded	verified deposited experimental structure

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

ERBB2 · ENSG00000141736 · P04626