CD47

Leukocyte surface antigen CD47. UniProt annotates extracellular residues 19–141, 198–207, 257–268.

Published binding interface

Structure 2JJS records CD47 in contact with SIRP-alpha extracellular domain. Select the contact residues to inspect this interface.

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RNA expression by cell type

Percentage of cells with detected CD47 RNA in the public colon adenocarcinoma cell groups.

Macrophages (group B)43.8%

Fibroblasts38.7%

B cells31.7%

Tumor cells31.1%

Macrophages (group A)31.0%

Endothelial cells29.9%

CD4 T cells29.1%

Dendritic cells27.5%

Natural killer cells26.1%

Regulatory T cells25.6%

CD8 T cells22.3%

Granulocytes17.6%

Adipocytes17.3%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 571. Source study · Measurements (JSON)

Inspect the molecular structure

Published reference structure

CD47 with SIRP-alpha

Deposited structure 2JJS. CD47 extracellular domain bound by SIRP-alpha.

PDB entry: 2JJS
Target ID: T-ENSG00000196776

SIRP-alpha extracellular domain · chains A, B (ribbon)
CD47 extracellular domain · chains C, D (ribbon)

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Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000196776
UniProt accession: Q08722
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 323
Sequence SHA-256: caa66c8069880514fd225b7c8673a1f4877dbfc3e15d10e69400cb453a226918

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Canonical amino-acid sequence

MWPLVAALLLGSACCGSAQLLFNKTKSVEFTFCNDTVVIPCFVTNMEAQNTTEVYVKWKFKGRDIYTFDGALNKSTVPTDFSSAKIEVSQLLKGDASLKMDKSDAVSHTGNYTCEVTELTREGETIIELKYRVVSWFSPNENILIVIFPIFAILLFWGQFGIKTLKYRSGGMDEKTIALLVAGLVITVIVIVGAILFVPGEYSLKNATGLGLIVTSTGILILLHYYVFSTAIGLTSFVIAILVIQVIAYILAVVGLSLCIAACIPMHGPLLISGLSILALAQLLGLVYMKFVASNQKTIQPPRKAVEEPLNAFKESKGMMNDE

Sequence positions 1–323

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–18

Membrane-spanning segments

142–162 (Helical); 177–197 (Helical); 208–228 (Helical); 236–256 (Helical); 269–289 (Helical)

Source-annotated domains

19–141 (Extracellular); 163–176 (Cytoplasmic); 198–207 (Extracellular); 229–235 (Cytoplasmic); 257–268 (Extracellular); 290–323 (Cytoplasmic)

Source-annotated extracellular intervals

19–141; 198–207; 257–268

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
19	141	123	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 2ff2ccc798399b9ec03b2c739e9f609c464bfa56941c2c5228fae7e35b561303 Amino-acid sequence for this intervalQLLFNKTKSVEFTFCNDTVVIPCFVTNMEAQNTTEVYVKWKFKGRDIYTFDGALNKSTVPTDFSSAKIEVSQLLKGDASLKMDKSDAVSHTGNYTCEVTELTREGETIIELKYRVVSWFSPNE
198	207	10	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 f0cb4b48a71b21dc7e7262627b210970793834e649b90b338cfd0694f8c05f9d Amino-acid sequence for this intervalVPGEYSLKNA
257	268	12	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 78b0356ad7ba6306b9e7a37f24443f67da834f47a846e9c615db268671f742c4 Amino-acid sequence for this intervalSLCIAACIPMHG

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: Q08722

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subcellular_location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:39121194, ECO:0000269|PubMed:7691831}; Multi-pass membrane protein {ECO:0000269|PubMed:7691831}.
transmembrane: TRANSMEM 142..162; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 177..197; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 208..228; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 236..256; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 269..289; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 19..141; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 163..176; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 198..207; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 229..235; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 257..268; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 290..323; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..18; /evidence="ECO:0000255"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Leukocyte surface antigen CD47
Protein location: Transmembrane protein
Canonical sequence: Q08722 · 323 amino acids
Extracellular region: UniProt annotates extracellular residues 19–141, 198–207, 257–268.

More structures and generated models

Structure snapshots

Expression in normal tissues

RNA specificity: Low tissue specificity
RNA distribution: Detected in all
Protein specificity: Tissue enhanced
Protein distribution: Detected in all
Immunohistochemistry reliability: Approved
Immunofluorescence reliability: Supported
Protein tissue-specific intensity: cerebral cortex: 77,252,632.2
Tissue cell-type enrichment: Adipose subcutaneous - Adipose progenitor cells
Subcellular location: Plasma membrane

Human Protein Atlas: CD47

Structures

Structures records linked to CD47.
Name	Stable ID	Action	Format	Status	Claim
2JJS	S-RCSB-2JJS	Not recorded	Not recorded	not recorded	verified deposited experimental structure

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

CD47 · ENSG00000196776 · Q08722