ITGB6

Integrin beta-6. UniProt annotates extracellular residues 22–709.

Protein-binder design

The campaign generated 16 binder designs with sequences and 3D models. None of the 14 scored complexes met the binding-site geometry criteria.

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RNA expression by cell type

Percentage of cells with detected ITGB6 RNA in the public colon adenocarcinoma cell groups.

Tumor cells8.5%

Fibroblasts1.0%

Endothelial cells0.5%

Natural killer cells0.5%

Macrophages (group B)0.4%

Adipocytes0.3%

Macrophages (group A)0.3%

CD8 T cells0.2%

CD4 T cells0.2%

Regulatory T cells0.2%

B cells0.1%

Dendritic cells0.0%

Granulocytes0.0%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 483. Source study · Measurements (JSON)

Inspect the molecular structure

Prepared target

Integrin alpha-v beta-6: prepared target

Target-only coordinates derived from deposited structure 8TCG. The design input retains alpha-v chain A and beta-6 chain B.

PDB entry: 8TCG
Target ID: T-ENSG00000115221

Integrin alpha-v · chain A (ribbon)
Integrin beta-6 · chain B (ribbon)

Download PNG · Download settings · Source coordinates (PDB)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000115221
UniProt accession: P18564
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 788
Sequence SHA-256: 871c82602ef83b96fc7e48abb1d783377410233b25a6bf2f2850d98965d21860

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Canonical amino-acid sequence

MGIELLCLFFLFLGRNDHVQGGCALGGAETCEDCLLIGPQCAWCAQENFTHPSGVGERCDTPANLLAKGCQLNFIENPVSQVEILKNKPLSVGRQKNSSDIVQIAPQSLILKLRPGGAQTLQVHVRQTEDYPVDLYYLMDLSASMDDDLNTIKELGSRLSKEMSKLTSNFRLGFGSFVEKPVSPFVKTTPEEIANPCSSIPYFCLPTFGFKHILPLTNDAERFNEIVKNQKISANIDTPEGGFDAIMQAAVCKEKIGWRNDSLHLLVFVSDADSHFGMDSKLAGIVIPNDGLCHLDSKNEYSMSTVLEYPTIGQLIDKLVQNNVLLIFAVTQEQVHLYENYAKLIPGATVGLLQKDSGNILQLIISAYEELRSEVELEVLGDTEGLNLSFTAICNNGTLFQHQKKCSHMKVGDTASFSVTVNIPHCERRSRHIIIKPVGLGDALELLVSPECNCDCQKEVEVNSSKCHHGNGSFQCGVCACHPGHMGPRCECGEDMLSTDSCKEAPDHPSCSGRGDCYCGQCICHLSPYGNIYGPYCQCDNFSCVRHKGLLCGGNGDCDCGECVCRSGWTGEYCNCTTSTDSCVSEDGVLCSGRGDCVCGKCVCTNPGASGPTCERCPTCGDPCNSKRSCIECHLSAAGQAREECVDKCKLAGATISEEEDFSKDGSVSCSLQGENECLITFLITTDNEGKTIIHSINEKDCPKPPNIPMIMLGVSLAILLIGVVLLCIWKLLVSFHDRKEVAKFEAERSKAKWQTGTNPLYRGSTSTFKNVTYKHREKQKVDLSTDC

Sequence positions 1–788

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–21

Membrane-spanning segments

710–730 (Helical)

Source-annotated domains

22–709 (Extracellular); 731–788 (Cytoplasmic)

Source-annotated extracellular intervals

22–709

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
22	709	688	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 fffa5ed00d2ecdd4a184898ac86a6433c99bf802c9e392988b6cae4975ad6a1a Amino-acid sequence for this intervalGCALGGAETCEDCLLIGPQCAWCAQENFTHPSGVGERCDTPANLLAKGCQLNFIENPVSQVEILKNKPLSVGRQKNSSDIVQIAPQSLILKLRPGGAQTLQVHVRQTEDYPVDLYYLMDLSASMDDDLNTIKELGSRLSKEMSKLTSNFRLGFGSFVEKPVSPFVKTTPEEIANPCSSIPYFCLPTFGFKHILPLTNDAERFNEIVKNQKISANIDTPEGGFDAIMQAAVCKEKIGWRNDSLHLLVFVSDADSHFGMDSKLAGIVIPNDGLCHLDSKNEYSMSTVLEYPTIGQLIDKLVQNNVLLIFAVTQEQVHLYENYAKLIPGATVGLLQKDSGNILQLIISAYEELRSEVELEVLGDTEGLNLSFTAICNNGTLFQHQKKCSHMKVGDTASFSVTVNIPHCERRSRHIIIKPVGLGDALELLVSPECNCDCQKEVEVNSSKCHHGNGSFQCGVCACHPGHMGPRCECGEDMLSTDSCKEAPDHPSCSGRGDCYCGQCICHLSPYGNIYGPYCQCDNFSCVRHKGLLCGGNGDCDCGECVCRSGWTGEYCNCTTSTDSCVSEDGVLCSGRGDCVCGKCVCTNPGASGPTCERCPTCGDPCNSKRSCIECHLSAAGQAREECVDKCKLAGATISEEEDFSKDGSVSCSLQGENECLITFLITTDNEGKTIIHSINEKDCPKPPNIP

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P18564

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subcellular_location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17545607}; Single-pass type I membrane protein {ECO:0000305}. Cell junction, focal adhesion {ECO:0000269|PubMed:17158881}.
transmembrane: TRANSMEM 710..730; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 22..709; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 731..788; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..21; /evidence="ECO:0000255"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Integrin beta-6
Protein location: Transmembrane protein
Canonical sequence: P18564 · 788 amino acids
Extracellular region: UniProt annotates extracellular residues 22–709.

More structures and generated models

Structure snapshots

Expression in normal tissues

RNA specificity: Tissue enhanced
RNA distribution: Detected in many
RNA tissue-specific nTPM: skeletal muscle: 74.9; tongue: 60.3
Protein specificity: Low tissue specificity
Protein distribution: Detected in many
Immunohistochemistry reliability: Approved
Immunofluorescence reliability: Approved
Tissue cell-type enrichment: Colon - Colon enterocytes, Lung - Alveolar cells type 2, Pancreas - Ductal cells, Prostate - Urothelial cells, Skeletal muscle - Skeletal myocytes, Stomach - Gastric mucous cells
Subcellular location: Nucleoplasm, Cell Junctions, Acrosome

Human Protein Atlas: ITGB6

Structures

Structures records linked to ITGB6.
Name	Stable ID	Action	Format	Status	Claim
8TCG	S-RCSB-8TCG	Not recorded	Not recorded	not recorded	verified deposited experimental structure
8TCG	S-RCSB-8TCG-RFD3-AB	Not recorded	Not recorded	not recorded	hash-bound target preparation and observed deposited interface geometry

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

ITGB6 · ENSG00000115221 · P18564