Surface AtlasCLDN3
Claudin-3. UniProt annotates extracellular residues 30–80, 137–159.
Predicted protein structure
A downloaded AlphaFold model connects the CLDN3 sequence to its predicted three-dimensional structure.
Open this viewRNA expression by cell type
Percentage of cells with detected CLDN3 RNA in the public colon adenocarcinoma cell groups.
Tumor cells49.1%
Dendritic cells10.5%
Macrophages (group B)8.8%
Endothelial cells8.1%
Fibroblasts7.9%
B cells7.3%
Macrophages (group A)5.8%
Natural killer cells5.7%
Regulatory T cells5.7%
Granulocytes5.7%
CD4 T cells5.1%
CD8 T cells4.3%
Adipocytes3.5%
Sequence & binding sites
Choose a protein region, search amino-acid letters, or inspect a recorded binding site.
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Open the sequence explorerSequence annotations and source records
Canonical sequence and topology
- Target ID
- T-ENSG00000165215
- UniProt accession
- O15551
- Sequence state
- available
- Canonical sequence
- Yes
- Length in amino acids
- 220
- Sequence SHA-256
- 0ba9b6b5e9b4d156e81521db8fb4d3e7cc60b100b6cbca960bdfd1c14ccf5b68
View and select the full canonical sequence
Gray shows the full canonical sequence. Colored spans mark the listed intervals.
Membrane-spanning segments
9–29 (Helical); 81–101 (Helical); 116–136 (Helical); 160–180 (Helical)
Source-annotated domains
1–8 (Cytoplasmic); 30–80 (Extracellular); 102–115 (Cytoplasmic); 137–159 (Extracellular); 181–220 (Cytoplasmic)
Source-annotated extracellular intervals
30–80; 137–159
UniProt annotates the following extracellular intervals.
| Start | End | Length | Sequence and source |
|---|---|---|---|
| 30 | 80 | 51 | Sequence and source
|
| 137 | 159 | 23 | Sequence and source
|
Sequence and topology sources
- Source role
- canonical-sequence
- Source
- alphafold-db-canonical-uniprot-field
- Extracted field
- uniprotSequence
- Source row accession
- Not recorded
- Source role
- reviewed-topology
- Source
- UniProt reviewed human surface-field snapshot
- Extracted field
- Not recorded
- Source row accession
- O15551
Download source snapshot (gzip)
- subcellular_location
- SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000269|PubMed:28028216, ECO:0000269|PubMed:30734065}. Cell membrane {ECO:0000269|PubMed:28028216}; Multi-pass membrane protein {ECO:0000255}.
- transmembrane
- TRANSMEM 9..29; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 81..101; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 116..136; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 160..180; /note="Helical"; /evidence="ECO:0000255"
- topological_domain
- TOPO_DOM 1..8; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 30..80; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 102..115; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 137..159; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 181..220; /note="Cytoplasmic"; /evidence="ECO:0000255"
- signal_peptide
- Not recorded
- lipidation
- Not recorded
Protein identity and location
- Protein
- Claudin-3
- Protein location
- Transmembrane protein
- Canonical sequence
- O15551 · 220 amino acids
- Extracellular region
- UniProt annotates extracellular residues 30–80, 137–159.
Expression in normal tissues
- RNA specificity
- Tissue enhanced
- RNA distribution
- Detected in many
- RNA tissue-specific nTPM
- intestine: 248.6; pancreas: 92.7; thyroid gland: 110.9
- Protein specificity
- Group enriched
- Protein distribution
- Detected in some
- Immunohistochemistry reliability
- Enhanced
- Immunofluorescence reliability
- Supported
- Protein tissue-specific intensity
- fallopian tube: 6,323,381.4; intestine: 7,054,165.0
- Tissue cell-type enrichment
- Breast - Breast glandular cells, Colon - Colon enterocytes, Minor Salivary Gland - Minor salivary glandular cells, Prostate - Prostate glandular cells, Skin - Eccrine sweat gland cells, Stomach - Gastric enteroendocrine cells
- Subcellular location
- Cell Junctions
Structures
A predicted target model is available.
Browse related molecular viewsSources and downloads
CLDN3 · ENSG00000165215 · O15551