CDH1

Cadherin-1. UniProt annotates extracellular residues 155–709.

Predicted protein structure

A downloaded AlphaFold model connects the CDH1 sequence to its predicted three-dimensional structure.

Open this view

RNA expression by cell type

Percentage of cells with detected CDH1 RNA in the public colon adenocarcinoma cell groups.

Tumor cells34.2%

Dendritic cells3.9%

Fibroblasts2.7%

Macrophages (group B)2.6%

Endothelial cells2.0%

Regulatory T cells2.0%

CD4 T cells1.8%

Macrophages (group A)1.7%

Natural killer cells1.7%

B cells1.4%

Adipocytes1.4%

CD8 T cells1.2%

Granulocytes0.9%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 12. Source study · Measurements (JSON)

Sequence & binding sites

Choose a protein region, search amino-acid letters, or inspect a recorded binding site.

Loading sequence…

Open the sequence explorer

Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000039068
UniProt accession: P12830
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 882
Sequence SHA-256: 6c2a333136e50ec3440f42cf6abea8d429a38b758d97b3f3610f96b0e25a1d9d

View and select the full canonical sequence

Canonical amino-acid sequence

MGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFTVPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQASVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTPPVGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDADDDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTATAVITVTDTNDNPPIFNPTTYKGQVPENEANVVITTLKVTDADAPNTPAWEAVYTILNDDGGQFVVTTNPVNNDGILKTAKGLDFEAKQQYILHVAVTNVVPFEVSLTTSTATVTVDVLDVNEAPIFVPPEKRVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDNAPIPEPRTIFFCERNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTQESIILKPKMALEVGDYKINLKLMDNQNKDQVTTLEVSVCDCEGAAGVCRKAQPVEAGLQIPAILGILGGILALLILILLLLLFLRRRAVVKEPLLPPEDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPRYLPRPANPDEIGNFIDENLKAADTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLADMYGGGEDD

Sequence positions 1–882

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–22

Membrane-spanning segments

710–730 (Helical)

Source-annotated domains

155–709 (Extracellular); 731–882 (Cytoplasmic)

Source-annotated extracellular intervals

155–709

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
155	709	555	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 19183fa907997e40ab08a4d454e3f47313249f65a3366eaf5556c1b4983c56e2 Amino-acid sequence for this intervalDWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTPPVGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDADDDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTATAVITVTDTNDNPPIFNPTTYKGQVPENEANVVITTLKVTDADAPNTPAWEAVYTILNDDGGQFVVTTNPVNNDGILKTAKGLDFEAKQQYILHVAVTNVVPFEVSLTTSTATVTVDVLDVNEAPIFVPPEKRVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDNAPIPEPRTIFFCERNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTQESIILKPKMALEVGDYKINLKLMDNQNKDQVTTLEVSVCDCEGAAGVCRKAQPVEAGLQIPA

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

Download source snapshot

Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P12830

Download source snapshot (gzip)

subcellular_location: SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:22294297, ECO:0000269|PubMed:27760340, ECO:0000269|PubMed:28169360}. Cell membrane {ECO:0000269|PubMed:19403558, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:28301459, ECO:0000269|PubMed:36309486}; Single-pass type I membrane protein. Endosome {ECO:0000269|PubMed:15689490}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:15689490}. Cytoplasm {ECO:0000269|PubMed:22294297}. Cell junction, desmosome {ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:29999492, ECO:0000269|PubMed:33596089}. Note=Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membrane. Recruited to desmosomes at the initial assembly phase and also accumulates progressively at mature desmosome cell-cell junctions (PubMed:25208567, PubMed:29999492). Localizes to cell-cell contacts as keratinocyte differentiation progresses (By similarity). {ECO:0000250|UniProtKB:P09803, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:29999492}.; SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:34742300}. Note=(Microbial infection) Proteolytically cleaved at the cell membrane upon H.pylori infection. {ECO:0000269|PubMed:34742300}.
transmembrane: TRANSMEM 710..730; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 155..709; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 731..882; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..22; /evidence="ECO:0000255"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Cadherin-1
Protein location: Transmembrane protein
Canonical sequence: P12830 · 882 amino acids
Extracellular region: UniProt annotates extracellular residues 155–709.

Expression in normal tissues

RNA specificity: Tissue enhanced
RNA distribution: Detected in many
RNA tissue-specific nTPM: parathyroid gland: 186.0
Protein specificity: Low tissue specificity
Protein distribution: Detected in all
Immunohistochemistry reliability: Enhanced
Immunofluorescence reliability: Supported
Tissue cell-type enrichment: Adipose visceral - Mesothelial cells, Colon - Colon enterocytes, Liver - Hepatocytes, Lung - Alveolar cells type 2, Prostate - Prostate glandular cells, Thyroid gland - Thyroid glandular cells
Subcellular location: Plasma membrane, Cell Junctions

Human Protein Atlas: CDH1

Structures

A predicted target model is available.

Browse related molecular views

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

CDH1 · ENSG00000039068 · P12830