Surface AtlasCLDN1
Claudin-1. UniProt annotates extracellular residues 29–81, 137–163.
Predicted protein structure
A downloaded AlphaFold model connects the CLDN1 sequence to its predicted three-dimensional structure.
Open this viewRNA expression by cell type
Percentage of cells with detected CLDN1 RNA in the public colon adenocarcinoma cell groups.
Tumor cells14.7%
Macrophages (group B)3.8%
Fibroblasts3.2%
Adipocytes2.0%
Macrophages (group A)0.7%
Endothelial cells0.7%
Regulatory T cells0.6%
CD4 T cells0.5%
CD8 T cells0.4%
B cells0.4%
Granulocytes0.3%
Dendritic cells0.0%
Natural killer cells0.0%
Sequence & binding sites
Choose a protein region, search amino-acid letters, or inspect a recorded binding site.
Loading sequence…
Open the sequence explorerSequence annotations and source records
Canonical sequence and topology
- Target ID
- T-ENSG00000163347
- UniProt accession
- O95832
- Sequence state
- available
- Canonical sequence
- Yes
- Length in amino acids
- 211
- Sequence SHA-256
- fc771ec8596f2cab6950a15ec5eebdc7dc4da3542c8c0d52145ee1795a6bb35b
View and select the full canonical sequence
Gray shows the full canonical sequence. Colored spans mark the listed intervals.
Membrane-spanning segments
8–28 (Helical); 82–102 (Helical); 116–136 (Helical); 164–184 (Helical)
Source-annotated domains
1–7 (Cytoplasmic); 29–81 (Extracellular); 103–115 (Cytoplasmic); 137–163 (Extracellular); 185–211 (Cytoplasmic)
Source-annotated extracellular intervals
29–81; 137–163
UniProt annotates the following extracellular intervals.
| Start | End | Length | Sequence and source |
|---|---|---|---|
| 29 | 81 | 53 | Sequence and source
|
| 137 | 163 | 27 | Sequence and source
|
Sequence and topology sources
- Source role
- canonical-sequence
- Source
- alphafold-db-canonical-uniprot-field
- Extracted field
- uniprotSequence
- Source row accession
- Not recorded
- Source role
- reviewed-topology
- Source
- UniProt reviewed human surface-field snapshot
- Extracted field
- Not recorded
- Source row accession
- O95832
Download source snapshot (gzip)
- subcellular_location
- SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000269|PubMed:20375010, ECO:0000269|PubMed:23407391, ECO:0000269|PubMed:30734065}. Cell membrane {ECO:0000269|PubMed:23704991}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:20375010}. Note=Associates with CD81 and the CLDN1-CD81 complex localizes to the basolateral cell membrane. {ECO:0000269|PubMed:20375010}.
- transmembrane
- TRANSMEM 8..28; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 82..102; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 116..136; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 164..184; /note="Helical"; /evidence="ECO:0000255"
- topological_domain
- TOPO_DOM 1..7; /note="Cytoplasmic"; /evidence="ECO:0000250"; TOPO_DOM 29..81; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 103..115; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 137..163; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 185..211; /note="Cytoplasmic"; /evidence="ECO:0000250"
- signal_peptide
- Not recorded
- lipidation
- Not recorded
Protein identity and location
- Protein
- Claudin-1
- Protein location
- Transmembrane protein
- Canonical sequence
- O95832 · 211 amino acids
- Extracellular region
- UniProt annotates extracellular residues 29–81, 137–163.
Expression in normal tissues
- RNA specificity
- Tissue enhanced
- RNA distribution
- Detected in many
- RNA tissue-specific nTPM
- liver: 289.7; skin 1: 275.6
- Protein specificity
- Tissue enriched
- Protein distribution
- Detected in single
- Immunohistochemistry reliability
- Enhanced
- Protein tissue-specific intensity
- liver: 9,638.2
- Tissue cell-type enrichment
- Adipose subcutaneous - Smooth muscle cells, Adipose visceral - Mesothelial cells, Pancreas - Ductal cells, Skin - Keratinocyte (other)
Structures
A predicted target model is available.
Browse related molecular viewsSources and downloads
CLDN1 · ENSG00000163347 · O95832