ENTPD1

Ectonucleoside triphosphate diphosphohydrolase 1. UniProt annotates extracellular residues 38–478.

Predicted protein structure

A downloaded AlphaFold model connects the ENTPD1 sequence to its predicted three-dimensional structure.

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RNA expression by cell type

Percentage of cells with detected ENTPD1 RNA in the public colon adenocarcinoma cell groups.

Endothelial cells46.0%

Regulatory T cells36.6%

Macrophages (group B)24.4%

CD8 T cells21.5%

Macrophages (group A)20.5%

Natural killer cells18.1%

B cells16.1%

Dendritic cells14.4%

Fibroblasts14.4%

CD4 T cells11.1%

Adipocytes7.2%

Tumor cells1.6%

Granulocytes1.4%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 652. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000138185
UniProt accession: P49961
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 510
Sequence SHA-256: adb29ded2d895f7484cdd8537164d3dac86b553ca66b082eff33785181e79126

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Canonical amino-acid sequence

MEDTKESNVKTFCSKNILAILGFSSIIAVIALLAVGLTQNKALPENVKYGIVLDAGSSHTSLYIYKWPAEKENDTGVVHQVEECRVKGPGISKFVQKVNEIGIYLTDCMERAREVIPRSQHQETPVYLGATAGMRLLRMESEELADRVLDVVERSLSNYPFDFQGARIITGQEEGAYGWITINYLLGKFSQKTRWFSIVPYETNNQETFGALDLGGASTQVTFVPQNQTIESPDNALQFRLYGKDYNVYTHSFLCYGKDQALWQKLAKDIQVASNEILRDPCFHPGYKKVVNVSDLYKTPCTKRFEMTLPFQQFEIQGIGNYQQCHQSILELFNTSYCPYSQCAFNGIFLPPLQGDFGAFSAFYFVMKFLNLTSEKVSQEKVTEMMKKFCAQPWEEIKTSYAGVKEKYLSEYCFSGTYILSLLLQGYHFTADSWEHIHFIGKIQGSDAGWTLGYMLNLTNMIPAEQPLSTPLSHSTYVFLMVLFSLVLFTVAIIGLLIFHKPSYFWKDMV

Sequence positions 1–510

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Membrane-spanning segments

17–37 (Helical); 479–499 (Helical)

Source-annotated domains

1–16 (Cytoplasmic); 38–478 (Extracellular); 500–510 (Cytoplasmic)

Lipid attachment sites

13–13 (S-palmitoyl cysteine)

Source-annotated extracellular intervals

38–478

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
38	478	441	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 eb64f0787af000748559baaef540efaa2e7117741826913bbb18a5c4fa7c9517 Amino-acid sequence for this intervalTQNKALPENVKYGIVLDAGSSHTSLYIYKWPAEKENDTGVVHQVEECRVKGPGISKFVQKVNEIGIYLTDCMERAREVIPRSQHQETPVYLGATAGMRLLRMESEELADRVLDVVERSLSNYPFDFQGARIITGQEEGAYGWITINYLLGKFSQKTRWFSIVPYETNNQETFGALDLGGASTQVTFVPQNQTIESPDNALQFRLYGKDYNVYTHSFLCYGKDQALWQKLAKDIQVASNEILRDPCFHPGYKKVVNVSDLYKTPCTKRFEMTLPFQQFEIQGIGNYQQCHQSILELFNTSYCPYSQCAFNGIFLPPLQGDFGAFSAFYFVMKFLNLTSEKVSQEKVTEMMKKFCAQPWEEIKTSYAGVKEKYLSEYCFSGTYILSLLLQGYHFTADSWEHIHFIGKIQGSDAGWTLGYMLNLTNMIPAEQPLSTPLSHSTYV

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P49961

Download source snapshot (gzip)

subcellular_location: SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:10636909, ECO:0000269|PubMed:8955160}; Multi-pass membrane protein {ECO:0000269|PubMed:10636909}. Membrane, caveola {ECO:0000269|PubMed:10636909}.
transmembrane: TRANSMEM 17..37; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 479..499; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 1..16; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 38..478; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 500..510; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: Not recorded
lipidation: LIPID 13; /note="S-palmitoyl cysteine"; /evidence="ECO:0000305|PubMed:10636909"

Download all canonical target sequences (FASTA)