RNF43

E3 ubiquitin-protein ligase RNF43. UniProt annotates extracellular residues 24–197.

Predicted protein structure

A downloaded AlphaFold model connects the RNF43 sequence to its predicted three-dimensional structure.

RNA expression in tumor samples

Median RNF43 RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples4,272.7

Other tumor types438 samples6,828.4

Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000108375
UniProt accession: Q68DV7
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 783
Sequence SHA-256: 7b56cff5f070e4c7e55714b1f98b39f2db4cb07561e706939bd44fe5dabee125

View and select the full canonical sequence

Canonical amino-acid sequence

MSGGHQLQLAALWPWLLMATLQAGFGRTGLVLAAAVESERSAEQKAIIRVIPLKMDPTGKLNLTLEGVFAGVAEITPAEGKLMQSHPLYLCNASDDDNLEPGFISIVKLESPRRAPRPCLSLASKARMAGERGASAVLFDITEDRAAAEQLQQPLGLTWPVVLIWGNDAEKLMEFVYKNQKAHVRIELKEPPAWPDYDVWILMTVVGTIFVIILASVLRIRCRPRHSRPDPLQQRTAWAISQLATRRYQASCRQARGEWPDSGSSCSSAPVCAICLEEFSEGQELRVISCLHEFHRNCVDPWLHQHRTCPLCMFNITEGDSFSQSLGPSRSYQEPGRRLHLIRQHPGHAHYHLPAAYLLGPSRSAVARPPRPGPFLPSQEPGMGPRHHRFPRAAHPRAPGEQQRLAGAQHPYAQGWGLSHLQSTSQHPAACPVPLRRARPPDSSGSGESYCTERSGYLADGPASDSSSGPCHGSSSDSVVNCTDISLQGVHGSSSTFCSSLSSDFDPLVYCSPKGDPQRVDMQPSVTSRPRSLDSVVPTGETQVSSHVHYHRHRHHHYKKRFQWHGRKPGPETGVPQSRPPIPRTQPQPEPPSPDQQVTRSNSAAPSGRLSNPQCPRALPEPAPGPVDASSICPSTSSLFNLQKSSLSARHPQRKRRGGPSEPTPGSRPQDATVHPACQIFPHYTPSVAYPWSPEAHPLICGPPGLDKRLLPETPGPCYSNSQPVWLCLTPRQPLEPHPPGEGPSEWSSDTAEGRPCPYPHCQVLSAQPGSEEELEELCEQAV

Sequence positions 1–783

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–23

Membrane-spanning segments

198–218 (Helical)

Source-annotated domains

24–197 (Extracellular); 219–783 (Cytoplasmic)

Source-annotated extracellular intervals

24–197

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
24	197	174	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 368218872698dcda0b7725de6677f48439eec9a59bf44cf79986c250f0e3e2ac Amino-acid sequence for this intervalGFGRTGLVLAAAVESERSAEQKAIIRVIPLKMDPTGKLNLTLEGVFAGVAEITPAEGKLMQSHPLYLCNASDDDNLEPGFISIVKLESPRRAPRPCLSLASKARMAGERGASAVLFDITEDRAAAEQLQQPLGLTWPVVLIWGNDAEKLMEFVYKNQKAHVRIELKEPPAWPDY

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: Q68DV7

Download source snapshot (gzip)

subcellular_location: SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Nucleus envelope. Note=According to a report, may be secreted. {ECO:0000269|PubMed:15492824}.
transmembrane: TRANSMEM 198..218; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 24..197; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 219..783; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..23; /evidence="ECO:0000255"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: E3 ubiquitin-protein ligase RNF43
Protein location: Transmembrane protein
Canonical sequence: Q68DV7 · 783 amino acids
Extracellular region: UniProt annotates extracellular residues 24–197.

Expression in normal tissues

RNA specificity: Tissue enhanced
RNA distribution: Detected in many
RNA tissue-specific nTPM: intestine: 21.4
Protein specificity: Not detected
Protein distribution: Not detected
Immunohistochemistry reliability: Uncertain
Tissue cell-type enrichment: Adipose visceral - Mesothelial cells, Heart muscle - Cardiomyocytes, Liver - Hepatocytes, Lung - Alveolar cells type 2, Skin - Keratinocyte (other), Spleen - B-cells (Spleen), Testis - Sertoli cells

Human Protein Atlas: RNF43

Structures

A predicted target model is available.

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Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

RNF43 · ENSG00000108375 · Q68DV7