MMP14

Matrix metalloproteinase-14. UniProt annotates extracellular residues 112–541.

Predicted protein structure

A downloaded AlphaFold model connects the MMP14 sequence to its predicted three-dimensional structure.

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RNA expression by cell type

Percentage of cells with detected MMP14 RNA in the public colon adenocarcinoma cell groups.

Fibroblasts48.7%

Macrophages (group B)40.5%

Endothelial cells29.1%

Adipocytes17.8%

Tumor cells12.7%

Macrophages (group A)6.6%

Granulocytes1.4%

Dendritic cells1.3%

CD4 T cells1.1%

B cells0.9%

Regulatory T cells0.9%

CD8 T cells0.5%

Natural killer cells0.5%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 82. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000157227
UniProt accession: P50281
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 582
Sequence SHA-256: 5f83c7ecb5c2eb7ffdf8d83f1de9543d8039381909ba6a87fdca0898eb47e260

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Canonical amino-acid sequence

MSPAPRPPRCLLLPLLTLGTALASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSVPDKPKNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPSGGRPDEGTEEETEVIIIEVDEEGGGAVSAAAVVLPVLLLLLVLAVGLAVFFFRRHGTPRRLLYCQRSLLDKV

Sequence positions 1–582

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–20

Membrane-spanning segments

542–562 (Helical)

Source-annotated domains

112–541 (Extracellular); 563–582 (Cytoplasmic)

Source-annotated extracellular intervals

112–541

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
112	541	430	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 422582c3c0d6995d3d5dd45dfd7609faeac2067a871c387f8391d7b9aa95ba24 Amino-acid sequence for this intervalYAIQGLKWQHNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSVPDKPKNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPSGGRPDEGTEEETEVIIIEVDEEGGGAVSAAA

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P50281

Download source snapshot (gzip)

subcellular_location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8015608}; Single-pass type I membrane protein {ECO:0000305}. Melanosome {ECO:0000269|PubMed:17081065}. Cytoplasm {ECO:0000269|PubMed:22065321}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Forms a complex with BST2 and localizes to the cytoplasm (PubMed:17081065). {ECO:0000269|PubMed:17081065}.
transmembrane: TRANSMEM 542..562; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 112..541; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 563..582; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..20; /evidence="ECO:0000255"
lipidation: Not recorded

Download all canonical target sequences (FASTA)