ANTXR1

Anthrax toxin receptor 1. UniProt annotates extracellular residues 33–321.

Predicted protein structure

A downloaded AlphaFold model connects the ANTXR1 sequence to its predicted three-dimensional structure.

Open this view

RNA expression by cell type

Percentage of cells with detected ANTXR1 RNA in the public colon adenocarcinoma cell groups.

Fibroblasts42.7%

Adipocytes15.3%

Macrophages (group B)6.2%

Endothelial cells2.4%

Tumor cells2.1%

Dendritic cells2.0%

Macrophages (group A)0.9%

Regulatory T cells0.7%

CD4 T cells0.6%

B cells0.4%

CD8 T cells0.4%

Natural killer cells0.2%

Granulocytes0.2%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 697. Source study · Measurements (JSON)

Sequence & binding sites

Choose a protein region, search amino-acid letters, or inspect a recorded binding site.

Loading sequence…

Open the sequence explorer

Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000169604
UniProt accession: Q9H6X2
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 564
Sequence SHA-256: cd36e0becd7cef67ed39ad1f6b614146a90737cff00d7fae025827a63b65e2ed

View and select the full canonical sequence

Canonical amino-acid sequence

MATAERRALGIGFQWLSLATLVLICAGQGGRREDGGPACYGGFDLYFILDKSGSVLHHWNEIYYFVEQLAHKFISPQLRMSFIVFSTRGTTLMKLTEDREQIRQGLEELQKVLPGGDTYMHEGFERASEQIYYENRQGYRTASVIIALTDGELHEDLFFYSEREANRSRDLGAIVYCVGVKDFNETQLARIADSKDHVFPVNDGFQALQGIIHSILKKSCIEILAAEPSTICAGESFQVVVRGNGFRHARNVDRVLCSFKINDSVTLNEKPFSVEDTYLLCPAPILKEVGMKAALQVSMNDGLSFISSSVIITTTHCSDGSILAIALLILFLLLALALLWWFWPLCCTVIIKEVPPPPAEESEEEDDDGLPKKKWPTVDASYYGGRGVGGIKRMEVRWGEKGSTEEGAKLEKAKNARVKMPEQEYEFPEPRNLNNNMRRPSSPRKWYSPIKGKLDALWVLLRKGYDRVSVMRPQPGDTGRCINFTRVKNNQPAKYPLNNAYHTSSPPPAPIYTPPPPAPHCPPPPPSAPTPPIPSPPSTLPPPPQAPPPNRAPPPSRPPPRPSV

Sequence positions 1–564

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–32

Membrane-spanning segments

322–342 (Helical)

Source-annotated domains

33–321 (Extracellular); 343–564 (Cytoplasmic)

Source-annotated extracellular intervals

33–321

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
33	321	289	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 3cb9e92a8ef9e54e7bb21666e64c1456f8697a6ae306ea54f8f0b0d8400c16e1 Amino-acid sequence for this intervalEDGGPACYGGFDLYFILDKSGSVLHHWNEIYYFVEQLAHKFISPQLRMSFIVFSTRGTTLMKLTEDREQIRQGLEELQKVLPGGDTYMHEGFERASEQIYYENRQGYRTASVIIALTDGELHEDLFFYSEREANRSRDLGAIVYCVGVKDFNETQLARIADSKDHVFPVNDGFQALQGIIHSILKKSCIEILAAEPSTICAGESFQVVVRGNGFRHARNVDRVLCSFKINDSVTLNEKPFSVEDTYLLCPAPILKEVGMKAALQVSMNDGLSFISSSVIITTTHCSDGS

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

Download source snapshot

Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: Q9H6X2

Download source snapshot (gzip)

subcellular_location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16762926, ECO:0000269|PubMed:30241478}; Single-pass type I membrane protein {ECO:0000269|PubMed:16762926}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:16762926}; Single-pass type I membrane protein {ECO:0000269|PubMed:16762926}. Cell projection, filopodium membrane {ECO:0000269|PubMed:16762926}; Single-pass type I membrane protein {ECO:0000269|PubMed:16762926}. Note=At the membrane of lamellipodia and at the tip of actin-enriched filopodia (PubMed:16762926). Colocalizes with actin at the base of lamellipodia (PubMed:16762926). {ECO:0000269|PubMed:16762926}.
transmembrane: TRANSMEM 322..342; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 33..321; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 343..564; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..32; /evidence="ECO:0000255"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Anthrax toxin receptor 1
Protein location: Transmembrane protein
Canonical sequence: Q9H6X2 · 564 amino acids
Extracellular region: UniProt annotates extracellular residues 33–321.

Expression in normal tissues

RNA specificity: Tissue enhanced
RNA distribution: Detected in many
RNA tissue-specific nTPM: blood vessel: 205.1
Protein specificity: Tissue enriched
Protein distribution: Detected in many
Immunofluorescence reliability: Uncertain
Protein tissue-specific intensity: blood vessel: 6,361,847.6
Tissue cell-type enrichment: Adrenal gland - Adrenal cortex cells, Heart muscle - Fibroblasts, Kidney - Fibroblasts, Liver - Hepatic stellate cells, Prostate - Fibroblasts, Spleen - Fibroblasts_1, Testis - Peritubular cells, Thyroid gland - Fibroblasts
Subcellular location: Vesicles

Human Protein Atlas: ANTXR1

Structures

A predicted target model is available.

Browse related molecular views

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

ANTXR1 · ENSG00000169604 · Q9H6X2