ANTXR2

Anthrax toxin receptor 2. UniProt annotates extracellular residues 34–318.

Sequence and protein regions

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RNA expression by cell type

Percentage of cells with detected ANTXR2 RNA in the public colon adenocarcinoma cell groups.

Fibroblasts28.8%

Dendritic cells27.5%

Adipocytes12.8%

Granulocytes11.1%

Macrophages (group B)10.9%

Tumor cells10.5%

Macrophages (group A)8.2%

Regulatory T cells7.3%

Endothelial cells6.7%

CD4 T cells5.1%

B cells3.3%

CD8 T cells2.4%

Natural killer cells1.0%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 436. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000163297
UniProt accession: P58335
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 489
Sequence SHA-256: 137799e546b8a031745941da4798a83fdc4ddd0d0caed7bdd9a2e36468e72ce5

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Canonical amino-acid sequence

MVAERSPARSPGSWLFPGLWLLVLSGPGGLLRAQEQPSCRRAFDLYFVLDKSGSVANNWIEIYNFVQQLAERFVSPEMRLSFIVFSSQATIILPLTGDRGKISKGLEDLKRVSPVGETYIHEGLKLANEQIQKAGGLKTSSIIIALTDGKLDGLVPSYAEKEAKISRSLGASVYCVGVLDFEQAQLERIADSKEQVFPVKGGFQALKGIINSILAQSCTEILELQPSSVCVGEEFQIVLSGRGFMLGSRNGSVLCTYTVNETYTTSVKPVSVQLNSMLCPAPILNKAGETLDVSVSFNGGKSVISGSLIVTATECSNGIAAIIVILVLLLLLGIGLMWWFWPLCCKVVIKDPPPPPAPAPKEEEEEPLPTKKWPTVDASYYGGRGVGGIKRMEVRWGDKGSTEEGARLEKAKNAVVKIPEETEEPIRPRPPRPKPTHQPPQTKWYTPIKGRLDALWALLRRQYDRVSLMRPQEGDEVCIWECIEKELTA

Sequence positions 1–489

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–33

Membrane-spanning segments

319–341 (Helical)

Source-annotated domains

34–318 (Extracellular); 342–489 (Cytoplasmic)

Source-annotated extracellular intervals

34–318

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
34	318	285	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 669fe689e1acf10f5f1ee5aa6dca197ee959b42c3fcae7830179da8e24daa566 Amino-acid sequence for this intervalQEQPSCRRAFDLYFVLDKSGSVANNWIEIYNFVQQLAERFVSPEMRLSFIVFSSQATIILPLTGDRGKISKGLEDLKRVSPVGETYIHEGLKLANEQIQKAGGLKTSSIIIALTDGKLDGLVPSYAEKEAKISRSLGASVYCVGVLDFEQAQLERIADSKEQVFPVKGGFQALKGIINSILAQSCTEILELQPSSVCVGEEFQIVLSGRGFMLGSRNGSVLCTYTVNETYTTSVKPVSVQLNSMLCPAPILNKAGETLDVSVSFNGGKSVISGSLIVTATECSNG

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P58335

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subcellular_location: SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:12700348}; Single-pass type I membrane protein {ECO:0000255}. Note=Expressed at the cell surface. {ECO:0000269|PubMed:12700348}.; SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11683410}; Single-pass type I membrane protein {ECO:0000255}. Note=Expressed predominantly within the endoplasmic reticulum and not at the plasma membrane. {ECO:0000269|PubMed:11683410}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305}.
transmembrane: TRANSMEM 319..341; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 34..318; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 342..489; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..33; /evidence="ECO:0000255"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Anthrax toxin receptor 2
Protein location: Transmembrane protein
Canonical sequence: P58335 · 489 amino acids
Extracellular region: UniProt annotates extracellular residues 34–318.

Expression in normal tissues

RNA specificity: Low tissue specificity
RNA distribution: Detected in all
Protein specificity: Low tissue specificity
Protein distribution: Detected in many
Tissue cell-type enrichment: Adrenal gland - Adrenal cortex cells, Kidney - Fibroblasts, Minor Salivary Gland - Macrophages, Pituitary gland - Fibroblasts, Spleen - Fibroblasts_1

Human Protein Atlas: ANTXR2

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

ANTXR2 · ENSG00000163297 · P58335