ATP1B1

Sodium/potassium-transporting ATPase subunit beta-1. UniProt annotates extracellular residues 63–303.

Sequence and protein regions

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RNA expression by cell type

Percentage of cells with detected ATP1B1 RNA in the public colon adenocarcinoma cell groups.

Tumor cells39.0%

Fibroblasts21.4%

Macrophages (group B)20.5%

Regulatory T cells13.3%

Dendritic cells13.1%

Granulocytes11.5%

Macrophages (group A)10.8%

Adipocytes10.7%

Endothelial cells7.0%

B cells5.3%

CD4 T cells4.9%

CD8 T cells4.1%

Natural killer cells3.3%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 298. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000143153
UniProt accession: P05026
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 303
Sequence SHA-256: 84332804df412712497a828955ceb3a10fb3fbfb970341032a8109e2422b9fad

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Canonical amino-acid sequence

MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISEFKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIVRFLEKYKDSAQRDDMIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKLNRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKRDEDKDKVGNVEYFGLGNSPGFPLQYYPYYGKLLQPKYLQPLLAVQFTNLTMDTEIRIECKAYGENIGYSEKDRFQGRFDVKIEVKS

Sequence positions 1–303

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Membrane-spanning segments

35–62 (Helical; Signal-anchor for type II membrane protein)

Source-annotated domains

1–34 (Cytoplasmic); 63–303 (Extracellular)

Source-annotated extracellular intervals

63–303

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
63	303	241	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 1fb13f2fd2113b306222af1a7765e8e2fdb4b97648ae83b81e3a67d50e8be24e Amino-acid sequence for this intervalEFKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIVRFLEKYKDSAQRDDMIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKLNRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKRDEDKDKVGNVEYFGLGNSPGFPLQYYPYYGKLLQPKYLQPLLAVQFTNLTMDTEIRIECKAYGENIGYSEKDRFQGRFDVKIEVKS

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P05026

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subcellular_location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:34011520}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P05027}. Apical cell membrane {ECO:0000250|UniProtKB:P07340}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P05027}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P14094}. Note=Colocalizes with OBSCN at the intercalated disk and sarcolemma in cardiomyocytes. Localizes in long striations at the level of Z and M lines. {ECO:0000250|UniProtKB:P14094}.
transmembrane: TRANSMEM 35..62; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000250|UniProtKB:P05027"
topological_domain: TOPO_DOM 1..34; /note="Cytoplasmic"; /evidence="ECO:0000250|UniProtKB:P05027"; TOPO_DOM 63..303; /note="Extracellular"; /evidence="ECO:0000250|UniProtKB:P05027"
signal_peptide: Not recorded
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Sodium/potassium-transporting ATPase subunit beta-1
Protein location: Transmembrane protein
Canonical sequence: P05026 · 303 amino acids
Extracellular region: UniProt annotates extracellular residues 63–303.

Expression in normal tissues

RNA specificity: Tissue enhanced
RNA distribution: Detected in all
RNA tissue-specific nTPM: kidney: 1,376.9
Protein specificity: Group enriched
Protein distribution: Detected in all
Immunohistochemistry reliability: Enhanced
Protein tissue-specific intensity: cerebral cortex: 614,480,670.2; salivary gland: 162,592,582.5
Tissue cell-type enrichment: Adipose visceral - Mesothelial cells, Lung - Alveolar cells type 2, Minor Salivary Gland - Minor salivary gland ductal cells, Skin - Eccrine sweat gland cells, Thyroid gland - Thyroid glandular cells

Human Protein Atlas: ATP1B1

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

ATP1B1 · ENSG00000143153 · P05026