AXL

Tyrosine-protein kinase receptor UFO. UniProt annotates extracellular residues 26–451.

Sequence and protein regions

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RNA expression by cell type

Percentage of cells with detected AXL RNA in the public colon adenocarcinoma cell groups.

Fibroblasts39.5%

Macrophages (group B)23.4%

Adipocytes19.9%

Macrophages (group A)8.1%

Dendritic cells2.0%

Tumor cells1.1%

Endothelial cells1.0%

Natural killer cells0.7%

Regulatory T cells0.4%

CD4 T cells0.4%

B cells0.4%

CD8 T cells0.2%

Granulocytes0.0%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 162. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000167601
UniProt accession: P30530
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 894
Sequence SHA-256: 0e1b606ba4a2733bcc0bfda24d9072606dc3876638804d08520b6d5c668ea019

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Canonical amino-acid sequence

MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQVQGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVFLGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPLATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTELEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGADPPTQPDPKDSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA

Sequence positions 1–894

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–25

Membrane-spanning segments

452–472 (Helical)

Source-annotated domains

26–451 (Extracellular); 473–894 (Cytoplasmic)

Source-annotated extracellular intervals

26–451

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
26	451	426	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 704b407b87037267766393493b84d18f5939e593e5ff8f86008904740b678240 Amino-acid sequence for this intervalAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQVQGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVFLGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPLATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTELEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPGQAQPVHQLVKEPSTPAFSWPWW

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P30530

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subcellular_location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28076778, ECO:0000269|PubMed:29379210, ECO:0000269|PubMed:7896447}; Single-pass type I membrane protein {ECO:0000269|PubMed:7896447}.
transmembrane: TRANSMEM 452..472; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 26..451; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 473..894; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..25; /evidence="ECO:0000255"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Tyrosine-protein kinase receptor UFO
Protein location: Transmembrane protein
Canonical sequence: P30530 · 894 amino acids
Extracellular region: UniProt annotates extracellular residues 26–451.

Expression in normal tissues

RNA specificity: Low tissue specificity
RNA distribution: Detected in all
Protein specificity: Low tissue specificity
Protein distribution: Detected in many
Immunohistochemistry reliability: Uncertain
Immunofluorescence reliability: Supported
Tissue cell-type enrichment: Testis - Sertoli cells
Subcellular location: Plasma membrane

Human Protein Atlas: AXL

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

AXL · ENSG00000167601 · P30530