BSG

Basigin. UniProt annotates extracellular residues 138–325.

Sequence and protein regions

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RNA expression by cell type

Percentage of cells with detected BSG RNA in the public colon adenocarcinoma cell groups.

Fibroblasts72.2%

Endothelial cells59.5%

Tumor cells48.5%

Macrophages (group B)47.5%

Dendritic cells45.1%

Regulatory T cells37.3%

Adipocytes37.0%

B cells36.2%

CD4 T cells33.6%

Macrophages (group A)31.8%

Granulocytes27.2%

Natural killer cells26.6%

CD8 T cells26.5%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 168. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000172270
UniProt accession: P35613
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 385
Sequence SHA-256: e4c2f484f4707a731baa61ab7f43e808c778198b657912e6500659e0a7e30308

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Canonical amino-acid sequence

MAAALFVLLGFALLGTHGASGAAGFVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDDQWGEYSCVFLPEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVRSHLAALWPFLGIVAEVLVLVTIIFIYEKRRKPEDVLDDDDAGSAPLKSSGQHQNDKGKNVRQRNSS

Sequence positions 1–385

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–21

Membrane-spanning segments

326–344 (Helical)

Source-annotated domains

138–325 (Extracellular); 345–385 (Cytoplasmic)

Source-annotated extracellular intervals

138–325

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
138	325	188	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 233f9a8d6024100bd9380c8a7f1b4193cfb4743561fa7bc134c6ea1c01b41c31 Amino-acid sequence for this intervalEPGTVFTTVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDDQWGEYSCVFLPEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVRSHLAAL

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P35613

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subcellular_location: SUBCELLULAR LOCATION: Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:17081065}.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:25957687}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453}. Photoreceptor inner segment {ECO:0000250|UniProtKB:P18572}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:P18572}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:11992541, ECO:0000269|PubMed:15688292, ECO:0000269|PubMed:15946952, ECO:0000269|PubMed:17127621, ECO:0000269|PubMed:21536654, ECO:0000269|PubMed:25825981, ECO:0000269|PubMed:26195724, ECO:0000269|PubMed:28409866, ECO:0000269|PubMed:29739904}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453}. Endosome {ECO:0000269|PubMed:29739904}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:15688292}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453}. Basolateral cell membrane {ECO:0000269|PubMed:17267690}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453}.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane {ECO:0000269|PubMed:21536654}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453}.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane {ECO:0000269|PubMed:21536654}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453}.
transmembrane: TRANSMEM 326..344; /note="Helical"; /evidence="ECO:0000269|PubMed:34625749, ECO:0000269|PubMed:38364890, ECO:0007744|PDB:7DCE, ECO:0007744|PDB:8XEJ"
topological_domain: TOPO_DOM 138..325; /note="Extracellular"; /evidence="ECO:0000269|PubMed:34625749, ECO:0000269|PubMed:38364890, ECO:0007744|PDB:7DCE, ECO:0007744|PDB:8XEJ"; TOPO_DOM 345..385; /note="Cytoplasmic"; /evidence="ECO:0000269|PubMed:34625749, ECO:0000269|PubMed:38364890, ECO:0007744|PDB:7DCE, ECO:0007744|PDB:8XEJ"
signal_peptide: SIGNAL 1..21; /evidence="ECO:0000269|PubMed:15340161"
lipidation: Not recorded

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Protein identity and location

Protein: Basigin
Protein location: Transmembrane protein
Canonical sequence: P35613 · 385 amino acids
Extracellular region: UniProt annotates extracellular residues 138–325.

Expression in normal tissues

RNA specificity: Tissue enhanced
RNA distribution: Detected in all
RNA tissue-specific nTPM: heart muscle: 1,787.2
Protein specificity: Tissue enhanced
Protein distribution: Detected in all
Immunohistochemistry reliability: Enhanced
Immunofluorescence reliability: Approved
Protein tissue-specific intensity: heart muscle: 137,634,602.3
Tissue cell-type enrichment: Adipose subcutaneous - Adipocytes (Subcutaneous), Heart muscle - Cardiomyocytes, Thyroid gland - Thyroid glandular cells
Subcellular location: Vesicles

Human Protein Atlas: BSG

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

BSG · ENSG00000172270 · P35613