CD19

B-lymphocyte antigen CD19. UniProt annotates extracellular residues 20–291.

Sequence and protein regions

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RNA expression by cell type

Percentage of cells with detected CD19 RNA in the public colon adenocarcinoma cell groups.

B cells19.8%

CD4 T cells1.0%

Macrophages (group B)0.8%

Fibroblasts0.6%

Regulatory T cells0.6%

CD8 T cells0.5%

Macrophages (group A)0.4%

Tumor cells0.3%

Adipocytes0.3%

Endothelial cells0.3%

Granulocytes0.2%

Dendritic cells0.0%

Natural killer cells0.0%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 18. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000177455
UniProt accession: P15391
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 556
Sequence SHA-256: 955c8406920379b400b21284c1ef1af93f34653cb8cc11fdf61e3aa84ef2b15e

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Canonical amino-acid sequence

MPPPRLLFFLLFLTPMEVRPEEPLVVKVEEGDNAVLQCLKGTSDGPTQQLTWSRESPLKPFLKLSLGLPGLGIHMRPLAIWLFIFNVSQQMGGFYLCQPGPPSEKAWQPGWTVNVEGSGELFRWNVSDLGGLGCGLKNRSSEGPSSPSGKLMSPKLYVWAKDRPEIWEGEPPCLPPRDSLNQSLSQDLTMAPGSTLWLSCGVPPDSVSRGPLSWTHVHPKGPKSLLSLELKDDRPARDMWVMETGLLLPRATAQDAGKYYCHRGNLTMSFHLEITARPVLWHWLLRTGGWKVSAVTLAYLIFCLCSLVGILHLQRALVLRRKRKRMTDPTRRFFKVTPPPGSGPQNQYGNVLSLPTPTSGLGRAQRWAAGLGGTAPSYGNPSSDVQADGALGSRSPPGVGPEEEEGEGYEEPDSEEDSEFYENDSNLGQDQLSQDGSGYENPEDEPLGPEDEDSFSNAESYENEDEELTQPVARTMDFLSPHGSAWDPSREATSLGSQSYEDMRGILYAAPQLRSIRGQPGPNHEEDADSYENMDNPDGPDPAWGGGGRMGTWSTR

Sequence positions 1–556

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–19

Membrane-spanning segments

292–313 (Helical)

Source-annotated domains

20–291 (Extracellular); 314–556 (Cytoplasmic)

Source-annotated extracellular intervals

20–291

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
20	291	272	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 10a724e985733a905f02d26c4a3c23696faa174b5587e8b139e778a1c92f1b97 Amino-acid sequence for this intervalPEEPLVVKVEEGDNAVLQCLKGTSDGPTQQLTWSRESPLKPFLKLSLGLPGLGIHMRPLAIWLFIFNVSQQMGGFYLCQPGPPSEKAWQPGWTVNVEGSGELFRWNVSDLGGLGCGLKNRSSEGPSSPSGKLMSPKLYVWAKDRPEIWEGEPPCLPPRDSLNQSLSQDLTMAPGSTLWLSCGVPPDSVSRGPLSWTHVHPKGPKSLLSLELKDDRPARDMWVMETGLLLPRATAQDAGKYYCHRGNLTMSFHLEITARPVLWHWLLRTGGWK

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P15391

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subcellular_location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1373518, ECO:0000269|PubMed:1383329, ECO:0000269|PubMed:16672701, ECO:0000269|PubMed:1702139, ECO:0000269|PubMed:2463100, ECO:0000269|PubMed:9317126, ECO:0000269|PubMed:9382888}; Single-pass type I membrane protein {ECO:0000305}. Membrane raft {ECO:0000250|UniProtKB:P25918}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P25918}.
transmembrane: TRANSMEM 292..313; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 20..291; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 314..556; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..19; /evidence="ECO:0000255"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: B-lymphocyte antigen CD19
Protein location: Transmembrane protein
Canonical sequence: P15391 · 556 amino acids
Extracellular region: UniProt annotates extracellular residues 20–291.

Expression in normal tissues

RNA specificity: Group enriched
RNA distribution: Detected in some
RNA tissue-specific nTPM: intestine: 31.2; lymphoid tissue: 70.8
Protein specificity: Tissue enriched
Protein distribution: Detected in single
Immunohistochemistry reliability: Enhanced
Protein tissue-specific intensity: lymphoid tissue: 2,075,914.7
Tissue cell-type enrichment: Lung - B-cells (Lung), Spleen - B-cells (Spleen), Testis - Early spermatids, Testis - Late spermatids

Human Protein Atlas: CD19

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

CD19 · ENSG00000177455 · P15391