Surface AtlasMucinous colon cancer

CD200

OX-2 membrane glycoprotein. UniProt annotates extracellular residues 31–232.

Sequence and protein regions

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RNA expression by cell type

Percentage of cells with detected CD200 RNA in the public colon adenocarcinoma cell groups.

Endothelial cells24.3%
Dendritic cells17.0%
Fibroblasts9.5%
Regulatory T cells6.5%
Adipocytes3.9%
B cells3.3%
CD4 T cells2.2%
Tumor cells1.3%
Macrophages (group A)0.6%
CD8 T cells0.6%
Macrophages (group B)0.4%
Granulocytes0.3%
Natural killer cells0.2%
RNA detection · Cancer Surfaceome Atlas, Table S6, row 375. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID
T-ENSG00000091972
UniProt accession
P41217
Sequence state
available
Canonical sequence
Yes
Length in amino acids
278
Sequence SHA-256
0bb64c2c264604736cb55682994d6fc7658581911a587b755f518dc673c57a98
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Sequence positions 1–278

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide
1–30
1–30
Membrane-spanning segments
233–259: Helical
233–259 (Helical)
Source-annotated domains
31–232: Extracellular260–278: Cytoplasmic
31–232 (Extracellular); 260–278 (Cytoplasmic)
Source-annotated extracellular intervals
31–232
31–232

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
StartEndLengthSequence and source
31232202
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
d0b8277597db4f2521f3e66daafc6c15ece2c66a1ed3cb0fc6ca67873e02b753
Sequence and topology sources
Source role
canonical-sequence
Source
alphafold-db-canonical-uniprot-field
Extracted field
uniprotSequence
Source row accession
Not recorded

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Source role
reviewed-topology
Source
UniProt reviewed human surface-field snapshot
Extracted field
Not recorded
Source row accession
P41217

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subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
transmembrane
TRANSMEM 233..259; /note="Helical"; /evidence="ECO:0000255"
topological_domain
TOPO_DOM 31..232; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 260..278; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide
SIGNAL 1..30; /evidence="ECO:0000255"
lipidation
Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein
OX-2 membrane glycoprotein
Protein location
Transmembrane protein
Canonical sequence
P41217 · 278 amino acids
Extracellular region
UniProt annotates extracellular residues 31–232.

Expression in normal tissues

RNA specificity
Tissue enhanced
RNA distribution
Detected in many
RNA tissue-specific nTPM
brain: 63.9
Protein specificity
Tissue enriched
Protein distribution
Detected in many
Immunohistochemistry reliability
Approved
Protein tissue-specific intensity
cerebral cortex: 24,321,338.3
Tissue cell-type enrichment
Adipose visceral - Mesothelial cells, Adrenal gland - Adrenal medulla cells, Breast - Breast myoepithelial cells, Kidney - Endothelial cells, Skeletal muscle - Fibroblasts

Sources and downloads

UniProt protein recordTarget measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

CD200 · ENSG00000091972 · P41217

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