Surface AtlasMucinous colon cancer

CD247

T-cell surface glycoprotein CD3 zeta chain. UniProt annotates extracellular residues 22–30.

Sequence and protein regions

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RNA expression by cell type

Percentage of cells with detected CD247 RNA in the public colon adenocarcinoma cell groups.

Natural killer cells51.5%
Regulatory T cells39.4%
CD8 T cells28.8%
CD4 T cells25.2%
Dendritic cells3.3%
Macrophages (group B)1.2%
B cells1.1%
Adipocytes0.6%
Fibroblasts0.6%
Tumor cells0.6%
Endothelial cells0.5%
Granulocytes0.5%
Macrophages (group A)0.3%
RNA detection · Cancer Surfaceome Atlas, Table S6, row 313. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID
T-ENSG00000198821
UniProt accession
P20963
Sequence state
available
Canonical sequence
Yes
Length in amino acids
164
Sequence SHA-256
72c57ad5dc4fd20675ae1e7ccfbc720ac243d369629ff5a76a21ac7166f19c9d
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Sequence positions 1–164

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide
1–21
1–21
Membrane-spanning segments
31–51: Helical
31–51 (Helical)
Source-annotated domains
22–30: Extracellular52–164: Cytoplasmic
22–30 (Extracellular); 52–164 (Cytoplasmic)
Source-annotated extracellular intervals
22–30
22–30

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
StartEndLengthSequence and source
22309
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
f8146ce4f8464873b0eb8e7b1af65c56b02a4d87e44c9ae8baa7198ba8ca6cd9
Sequence and topology sources
Source role
canonical-sequence
Source
alphafold-db-canonical-uniprot-field
Extracted field
uniprotSequence
Source row accession
Not recorded

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Open sequence source
Source role
reviewed-topology
Source
UniProt reviewed human surface-field snapshot
Extracted field
Not recorded
Source row accession
P20963

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subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P24161}; Single-pass type I membrane protein.
transmembrane
TRANSMEM 31..51; /note="Helical"; /evidence="ECO:0000255"
topological_domain
TOPO_DOM 22..30; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 52..164; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide
SIGNAL 1..21
lipidation
Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein
T-cell surface glycoprotein CD3 zeta chain
Protein location
Transmembrane protein
Canonical sequence
P20963 · 164 amino acids
Extracellular region
UniProt annotates extracellular residues 22–30.

Expression in normal tissues

RNA specificity
Group enriched
RNA distribution
Detected in many
RNA tissue-specific nTPM
bone marrow: 38.0; lymphoid tissue: 150.1
Protein specificity
Group enriched
Protein distribution
Detected in some
Immunohistochemistry reliability
Enhanced
Protein tissue-specific intensity
lung: 14,459,433.9; lymphoid tissue: 33,242,355.9
Tissue cell-type enrichment
Adipose subcutaneous - T-cells, Adipose visceral - T-cells, Adrenal gland - T-cells, Breast - T-cells, Colon - T-cells, Heart muscle - T-cells, Kidney - T-cells, Liver - NK-cells (Liver), Lung - NK-cells (Lung), Minor Salivary Gland - T-cells, Pancreas - T-cells, Pituitary gland - T-cells, Prostate - T-cells, Skin - T-cells, Stomach - T-cells, Thyroid gland - T-cells

Sources and downloads

UniProt protein recordTarget measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

CD247 · ENSG00000198821 · P20963

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