CD248

Endosialin. UniProt annotates extracellular residues 18–687.

Sequence and protein regions

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RNA expression by cell type

Percentage of cells with detected CD248 RNA in the public colon adenocarcinoma cell groups.

Fibroblasts40.3%

Adipocytes14.4%

Endothelial cells1.9%

CD8 T cells0.9%

Tumor cells0.9%

CD4 T cells0.8%

Macrophages (group B)0.7%

B cells0.6%

Macrophages (group A)0.5%

Regulatory T cells0.2%

Granulocytes0.2%

Dendritic cells0.0%

Natural killer cells0.0%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 296. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000174807
UniProt accession: Q9HCU0
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 757
Sequence SHA-256: 5de140e38af6ff4da85214e6fdc7a93faa5b9be0b770eb0329f411900d5588c3

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Canonical amino-acid sequence

MLLRLLLAWAAAGPTLGQDPWAAEPRAACGPSSCYALFPRRRTFLEAWRACRELGGDLATPRTPEEAQRVDSLVGAGPASRLLWIGLQRQARQCQLQRPLRGFTWTTGDQDTAFTNWAQPASGGPCPAQRCVALEASGEHRWLEGSCTLAVDGYLCQFGFEGACPALQDEAGQAGPAVYTTPFHLVSTEFEWLPFGSVAAVQCQAGRGASLLCVKQPEGGVGWSRAGPLCLGTGCSPDNGGCEHECVEEVDGHVSCRCTEGFRLAADGRSCEDPCAQAPCEQQCEPGGPQGYSCHCRLGFRPAEDDPHRCVDTDECQIAGVCQQMCVNYVGGFECYCSEGHELEADGISCSPAGAMGAQASQDLGDELLDDGEDEEDEDEAWKAFNGGWTEMPGILWMEPTQPPDFALAYRPSFPEDREPQIPYPEPTWPPPLSAPRVPYHSSVLSVTRPVVVSATHPTLPSAHQPPVIPATHPALSRDHQIPVIAANYPDLPSAYQPGILSVSHSAQPPAHQPPMISTKYPELFPAHQSPMFPDTRVAGTQTTTHLPGIPPNHAPLVTTLGAQLPPQAPDALVLRTQATQLPIIPTAQPSLTTTSRSPVSPAHQISVPAATQPAALPTLLPSQSPTNQTSPISPTHPHSKAPQIPREDGPSPKLALWLPSPAPTAAPTALGEAGLAEHSQRDDRWLLVALLVPTCVFLVVLLALGIVYCTRCGPHAPNKRITDCYRWVIHAGSKSPTEPMPPRGSLTGVQTCRTSV

Sequence positions 1–757

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–17

Membrane-spanning segments

688–708 (Helical)

Source-annotated domains

18–687 (Extracellular); 709–757 (Cytoplasmic)

Source-annotated extracellular intervals

18–687

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
18	687	670	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 1c6c0ab714b92f1ce27bc2d9badd24795891e35d1d378d594e220461889ea662 Amino-acid sequence for this intervalQDPWAAEPRAACGPSSCYALFPRRRTFLEAWRACRELGGDLATPRTPEEAQRVDSLVGAGPASRLLWIGLQRQARQCQLQRPLRGFTWTTGDQDTAFTNWAQPASGGPCPAQRCVALEASGEHRWLEGSCTLAVDGYLCQFGFEGACPALQDEAGQAGPAVYTTPFHLVSTEFEWLPFGSVAAVQCQAGRGASLLCVKQPEGGVGWSRAGPLCLGTGCSPDNGGCEHECVEEVDGHVSCRCTEGFRLAADGRSCEDPCAQAPCEQQCEPGGPQGYSCHCRLGFRPAEDDPHRCVDTDECQIAGVCQQMCVNYVGGFECYCSEGHELEADGISCSPAGAMGAQASQDLGDELLDDGEDEEDEDEAWKAFNGGWTEMPGILWMEPTQPPDFALAYRPSFPEDREPQIPYPEPTWPPPLSAPRVPYHSSVLSVTRPVVVSATHPTLPSAHQPPVIPATHPALSRDHQIPVIAANYPDLPSAYQPGILSVSHSAQPPAHQPPMISTKYPELFPAHQSPMFPDTRVAGTQTTTHLPGIPPNHAPLVTTLGAQLPPQAPDALVLRTQATQLPIIPTAQPSLTTTSRSPVSPAHQISVPAATQPAALPTLLPSQSPTNQTSPISPTHPHSKAPQIPREDGPSPKLALWLPSPAPTAAPTALGEAGLAEHSQRDDRWL

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: Q9HCU0

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subcellular_location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
transmembrane: TRANSMEM 688..708; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 18..687; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 709..757; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..17; /evidence="ECO:0000255"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Endosialin
Protein location: Transmembrane protein
Canonical sequence: Q9HCU0 · 757 amino acids
Extracellular region: UniProt annotates extracellular residues 18–687.

Expression in normal tissues

RNA specificity: Tissue enhanced
RNA distribution: Detected in many
RNA tissue-specific nTPM: adipose tissue: 219.6; breast: 146.3
Protein specificity: Tissue enhanced
Protein distribution: Detected in many
Immunohistochemistry reliability: Enhanced
Immunofluorescence reliability: Approved
Protein tissue-specific intensity: skin: 27,149,388.5
Tissue cell-type enrichment: Adrenal gland - Fibroblasts, Breast - Adipocytes (Breast), Colon - Fibroblasts, Liver - Hepatic stellate cells, Minor Salivary Gland - Fibroblasts, Pituitary gland - Fibroblasts, Prostate - Fibroblasts, Skeletal muscle - Fibroblasts, Skin - Fibroblasts_1, Skin - Fibroblasts_2, Spleen - Fibroblasts_1, Stomach - Fibroblasts
Subcellular location: Plasma membrane

Human Protein Atlas: CD248

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

CD248 · ENSG00000174807 · Q9HCU0