CD276

CD276 antigen. UniProt annotates extracellular residues 29–466.

Predicted protein structure

A downloaded AlphaFold model connects the CD276 sequence to its predicted three-dimensional structure.

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RNA expression by cell type

Percentage of cells with detected CD276 RNA in the public colon adenocarcinoma cell groups.

Fibroblasts24.6%

Endothelial cells15.8%

Macrophages (group B)15.7%

Tumor cells6.7%

Adipocytes6.2%

Granulocytes3.3%

Dendritic cells2.6%

Regulatory T cells1.5%

Macrophages (group A)1.5%

Natural killer cells0.7%

CD4 T cells0.7%

B cells0.5%

CD8 T cells0.3%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 221. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000103855
UniProt accession: Q5ZPR3
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 534
Sequence SHA-256: cfc4df123ba3da6e3b2e07252c3a396aa97265dcb448d12e36a85e241758eda5

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Canonical amino-acid sequence

MLRRRGSPGMGVHVGAALGALWFCLTGALEVQVPEDPVVALVGTDATLCCSFSPEPGFSLAQLNLIWQLTDTKQLVHSFAEGQDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEGSFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVTITCSSYQGYPEAEVFWQDGQGVPLTGNVTTSQMANEQGLFDVHSILRVVLGANGTYSCLVRNPVLQQDAHSSVTITPQRSPTGAVEVQVPEDPVVALVGTDATLRCSFSPEPGFSLAQLNLIWQLTDTKQLVHSFTEGRDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEGSFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVTITCSSYRGYPEAEVFWQDGQGVPLTGNVTTSQMANEQGLFDVHSVLRVVLGANGTYSCLVRNPVLQQDAHGSVTITGQPMTFPPEALWVTVGLSVCLIALLVALAFVCWRKIKQSCEEENAGAEDQDGEGEGSKTALQPLKHSDSKEDDGQEIA

Sequence positions 1–534

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–28

Membrane-spanning segments

467–487 (Helical)

Source-annotated domains

29–466 (Extracellular); 488–534 (Cytoplasmic)

Source-annotated extracellular intervals

29–466

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
29	466	438	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 c84d2a475eddeeae2ab36c8805423eeb245a08088d0f4ef0d9f7963b5f20f27d Amino-acid sequence for this intervalLEVQVPEDPVVALVGTDATLCCSFSPEPGFSLAQLNLIWQLTDTKQLVHSFAEGQDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEGSFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVTITCSSYQGYPEAEVFWQDGQGVPLTGNVTTSQMANEQGLFDVHSILRVVLGANGTYSCLVRNPVLQQDAHSSVTITPQRSPTGAVEVQVPEDPVVALVGTDATLRCSFSPEPGFSLAQLNLIWQLTDTKQLVHSFTEGRDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEGSFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVTITCSSYRGYPEAEVFWQDGQGVPLTGNVTTSQMANEQGLFDVHSVLRVVLGANGTYSCLVRNPVLQQDAHGSVTITGQPMTFPPEA

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: Q5ZPR3

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subcellular_location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
transmembrane: TRANSMEM 467..487; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 29..466; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 488..534; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..28; /evidence="ECO:0000269|PubMed:15340161"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: CD276 antigen
Protein location: Transmembrane protein
Canonical sequence: Q5ZPR3 · 534 amino acids
Extracellular region: UniProt annotates extracellular residues 29–466.

Expression in normal tissues

RNA specificity: Low tissue specificity
RNA distribution: Detected in many
Protein specificity: Tissue enhanced
Protein distribution: Detected in many
Immunohistochemistry reliability: Enhanced
Immunofluorescence reliability: Approved
Protein tissue-specific intensity: ovary: 12,441,216.3
Tissue cell-type enrichment: Adipose subcutaneous - Adipose progenitor cells, Adipose visceral - Adipose progenitor cells, Breast - Fibroblasts, Skin - Fibroblasts_2, Spleen - Fibroblasts_1, Thyroid gland - Fibroblasts
Subcellular location: Vesicles

Human Protein Atlas: CD276

Structures

A predicted target model is available.

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Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

CD276 · ENSG00000103855 · Q5ZPR3