CD34

Hematopoietic progenitor cell antigen CD34. UniProt annotates extracellular residues 32–290.

Sequence and protein regions

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RNA expression by cell type

Percentage of cells with detected CD34 RNA in the public colon adenocarcinoma cell groups.

Endothelial cells63.1%

Fibroblasts18.6%

Adipocytes10.1%

Regulatory T cells1.0%

Tumor cells0.9%

Macrophages (group B)0.8%

B cells0.7%

CD4 T cells0.5%

Granulocytes0.5%

CD8 T cells0.5%

Macrophages (group A)0.5%

Natural killer cells0.2%

Dendritic cells0.0%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 125. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000174059
UniProt accession: P28906
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 385
Sequence SHA-256: ed79decd0ebecf11db88814fefce77dd70f004d2ae0bb732e76e6bb59cba05b3

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Canonical amino-acid sequence

MLVRRGARAGPRMPRGWTALCLLSLLPSGFMSLDNNGTATPELPTQGTFSNVSTNVSYQETTTPSTLGSTSLHPVSQHGNEATTNITETTVKFTSTSVITSVYGNTNSSVQSQTSVISTVFTTPANVSTPETTLKPSLSPGNVSDLSTTSTSLATSPTKPYTSSSPILSDIKAEIKCSGIREVKLTQGICLEQNKTSSCAEFKKDRGEGLARVLCGEEQADADAGAQVCSLLLAQSEVRPQCLLLVLANRTEISSKLQLMKKHQSDLKKLGILDFTEQDVASHQSYSQKTLIALVTSGALLAVLGITGYFLMNRRSWSPTGERLGEDPYYTENGGGQGYSSGPGTSPEAQGKASVNRGAQENGTGQATSRNGHSARQHVVADTEL

Sequence positions 1–385

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–31

Membrane-spanning segments

291–311 (Helical)

Source-annotated domains

32–290 (Extracellular); 312–385 (Cytoplasmic)

Source-annotated extracellular intervals

32–290

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
32	290	259	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 f20fdd26a11e65d09e1253baf20b29a5e134d22fea60d25ba3c1a76858072039 Amino-acid sequence for this intervalSLDNNGTATPELPTQGTFSNVSTNVSYQETTTPSTLGSTSLHPVSQHGNEATTNITETTVKFTSTSVITSVYGNTNSSVQSQTSVISTVFTTPANVSTPETTLKPSLSPGNVSDLSTTSTSLATSPTKPYTSSSPILSDIKAEIKCSGIREVKLTQGICLEQNKTSSCAEFKKDRGEGLARVLCGEEQADADAGAQVCSLLLAQSEVRPQCLLLVLANRTEISSKLQLMKKHQSDLKKLGILDFTEQDVASHQSYSQKT

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P28906

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subcellular_location: SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
transmembrane: TRANSMEM 291..311; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 32..290; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 312..385; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..31; /evidence="ECO:0000269|PubMed:1370171, ECO:0000269|PubMed:2462139"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Hematopoietic progenitor cell antigen CD34
Protein location: Transmembrane protein
Canonical sequence: P28906 · 385 amino acids
Extracellular region: UniProt annotates extracellular residues 32–290.

Expression in normal tissues

RNA specificity: Low tissue specificity
RNA distribution: Detected in all
Protein specificity: Low tissue specificity
Protein distribution: Detected in many
Immunohistochemistry reliability: Enhanced
Immunofluorescence reliability: Approved
Tissue cell-type enrichment: Pancreas - Endothelial cells, Prostate - Endothelial cells, Testis - Endothelial cells
Subcellular location: Plasma membrane, Cell Junctions

Human Protein Atlas: CD34

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

CD34 · ENSG00000174059 · P28906