CD4

T-cell surface glycoprotein CD4. UniProt annotates extracellular residues 26–396.

Sequence and protein regions

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RNA expression by cell type

Percentage of cells with detected CD4 RNA in the public colon adenocarcinoma cell groups.

Macrophages (group B)48.6%

Macrophages (group A)29.0%

Regulatory T cells28.0%

Dendritic cells26.8%

CD4 T cells16.0%

Granulocytes4.3%

Fibroblasts4.3%

Adipocytes2.4%

CD8 T cells1.2%

Endothelial cells0.7%

Tumor cells0.6%

Natural killer cells0.5%

B cells0.4%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 243. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000010610
UniProt accession: P01730
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 458
Sequence SHA-256: b598cecf65abf705dba5812286f09dfd6921c638b3f0c7cbee5a156df090db63

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Canonical amino-acid sequence

MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI

Sequence positions 1–458

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–25

Membrane-spanning segments

397–418 (Helical)

Source-annotated domains

26–396 (Extracellular); 419–458 (Cytoplasmic)

Lipid attachment sites

419–419 (S-palmitoyl cysteine); 422–422 (S-palmitoyl cysteine)

Source-annotated extracellular intervals

26–396

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
26	396	371	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 2c0aabb2af63eeddad2dad86c845ccc2a2ac709bf3d25389a85e462abf4215fe Amino-acid sequence for this intervalKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQP

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P01730

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subcellular_location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12089508, ECO:0000269|PubMed:12517957, ECO:0000269|PubMed:2823150, ECO:0000269|PubMed:2990730}; Single-pass type I membrane protein {ECO:0000269|PubMed:12517957, ECO:0000269|PubMed:15340161, ECO:0000269|PubMed:1708753}. Note=Localizes to lipid rafts (PubMed:12517957, PubMed:9168119). Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
transmembrane: TRANSMEM 397..418; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 26..396; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 419..458; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..25; /evidence="ECO:0000269|PubMed:15340161, ECO:0000269|PubMed:2592374"
lipidation: LIPID 419; /note="S-palmitoyl cysteine"; /evidence="ECO:0000269|PubMed:1618861"; LIPID 422; /note="S-palmitoyl cysteine"; /evidence="ECO:0000269|PubMed:1618861"

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: T-cell surface glycoprotein CD4
Protein location: Transmembrane protein
Canonical sequence: P01730 · 458 amino acids
Extracellular region: UniProt annotates extracellular residues 26–396.

Expression in normal tissues

RNA specificity: Tissue enhanced
RNA distribution: Detected in all
RNA tissue-specific nTPM: liver: 143.1; lymphoid tissue: 204.2; parathyroid gland: 163.6
Protein specificity: Tissue enhanced
Protein distribution: Detected in some
Immunohistochemistry reliability: Enhanced
Immunofluorescence reliability: Supported
Protein tissue-specific intensity: lymphoid tissue: 1,971,944.4
Tissue cell-type enrichment: Adrenal gland - Macrophages, Minor Salivary Gland - Macrophages, Skeletal muscle - Macrophages, Spleen - Macrophages, Stomach - Macrophages
Subcellular location: Plasma membrane

Human Protein Atlas: CD4

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

CD4 · ENSG00000010610 · P01730