CD44

CD44 antigen. UniProt annotates extracellular residues 21–649.

Sequence and protein regions

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RNA expression by cell type

Percentage of cells with detected CD44 RNA in the public colon adenocarcinoma cell groups.

Granulocytes66.4%

Regulatory T cells62.0%

Macrophages (group B)60.9%

Macrophages (group A)60.0%

CD4 T cells57.5%

CD8 T cells54.3%

Fibroblasts45.1%

B cells43.5%

Dendritic cells42.5%

Natural killer cells34.2%

Tumor cells28.4%

Adipocytes26.5%

Endothelial cells6.7%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 44. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000026508
UniProt accession: P16070
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 742
Sequence SHA-256: e19d744d038c01b8cc22bd7b2f0f42db427460e1ae0c3c033bfda05a992057ff

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Canonical amino-acid sequence

MDKFWWHAAWGLCLVPLSLAQIDLNITCRFAGVFHVEKNGRYSISRTEAADLCKAFNSTLPTMAQMEKALSIGFETCRYGFIEGHVVIPRIHPNSICAANNTGVYILTSNTSQYDTYCFNASAPPEEDCTSVTDLPNAFDGPITITIVNRDGTRYVQKGEYRTNPEDIYPSNPTDDDVSSGSSSERSSTSGGYIFYTFSTVHPIPDEDSPWITDSTDRIPATTLMSTSATATETATKRQETWDWFSWLFLPSESKNHLHTTTQMAGTSSNTISAGWEPNEENEDERDRHLSFSGSGIDDDEDFISSTISTTPRAFDHTKQNQDWTQWNPSHSNPEVLLQTTTRMTDVDRNGTTAYEGNWNPEAHPPLIHHEHHEEEETPHSTSTIQATPSSTTEETATQKEQWFGNRWHEGYRQTPKEDSHSTTGTAAASAHTSHPMQGRTTPSPEDSSWTDFFNPISHPMGRGHQAGRRMDMDSSHSITLQPTANPNTGLVEDLDRTGPLSMTTQQSNSQSFSTSHEGLEEDKDHPTTSTLTSSNRNDVTGGRRDPNHSEGSTTLLEGYTSHYPHTKESRTFIPVTSAKTGSFGVTAVTVGDSNSNVNRSLSGDQDTFHPSGGSHTTHGSESDGHSHGSQEGGANTTSGPIRTPQIPEWLIILASLLALALILAVCIAVNSRRRCGQKKKLVINSGNGAVEDRKPSGLNGEASKSQEMVHLVNKESSETPDQFMTADETRNLQNVDMKIGV

Sequence positions 1–742

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–20

Membrane-spanning segments

650–670 (Helical)

Source-annotated domains

21–649 (Extracellular); 671–742 (Cytoplasmic)

Source-annotated extracellular intervals

21–649

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
21	649	629	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 0239db9f1b89ab0f3ed3ae9d8ef1812b089351cb5010cb5cdbd75f39fb863cb8 Amino-acid sequence for this intervalQIDLNITCRFAGVFHVEKNGRYSISRTEAADLCKAFNSTLPTMAQMEKALSIGFETCRYGFIEGHVVIPRIHPNSICAANNTGVYILTSNTSQYDTYCFNASAPPEEDCTSVTDLPNAFDGPITITIVNRDGTRYVQKGEYRTNPEDIYPSNPTDDDVSSGSSSERSSTSGGYIFYTFSTVHPIPDEDSPWITDSTDRIPATTLMSTSATATETATKRQETWDWFSWLFLPSESKNHLHTTTQMAGTSSNTISAGWEPNEENEDERDRHLSFSGSGIDDDEDFISSTISTTPRAFDHTKQNQDWTQWNPSHSNPEVLLQTTTRMTDVDRNGTTAYEGNWNPEAHPPLIHHEHHEEEETPHSTSTIQATPSSTTEETATQKEQWFGNRWHEGYRQTPKEDSHSTTGTAAASAHTSHPMQGRTTPSPEDSSWTDFFNPISHPMGRGHQAGRRMDMDSSHSITLQPTANPNTGLVEDLDRTGPLSMTTQQSNSQSFSTSHEGLEEDKDHPTTSTLTSSNRNDVTGGRRDPNHSEGSTTLLEGYTSHYPHTKESRTFIPVTSAKTGSFGVTAVTVGDSNSNVNRSLSGDQDTFHPSGGSHTTHGSESDGHSHGSQEGGANTTSGPIRTPQIPE

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P16070

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subcellular_location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22726066, ECO:0000269|PubMed:23589287, ECO:0000269|PubMed:40544280}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, microvillus {ECO:0000250|UniProtKB:P15379}. Secreted {ECO:0000269|PubMed:25326458, ECO:0000269|PubMed:36213313, ECO:0000269|PubMed:37453717}. Note=Colocalizes with actin in membrane protrusions at wounding edges. Co-localizes with RDX, EZR and MSN in microvilli. Localizes to cholesterol-rich membrane-bound lipid raft domains. {ECO:0000250|UniProtKB:P15379, ECO:0000269|PubMed:23589287}.
transmembrane: TRANSMEM 650..670; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 21..649; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 671..742; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..20; /evidence="ECO:0000250"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: CD44 antigen
Protein location: Transmembrane protein
Canonical sequence: P16070 · 742 amino acids
Extracellular region: UniProt annotates extracellular residues 21–649.

Expression in normal tissues

RNA specificity: Tissue enhanced
RNA distribution: Detected in all
RNA tissue-specific nTPM: salivary gland: 469.7
Protein specificity: Tissue enhanced
Protein distribution: Detected in all
Immunohistochemistry reliability: Enhanced
Immunofluorescence reliability: Supported
Protein tissue-specific intensity: salivary gland: 365,465,403.8
Tissue cell-type enrichment: Adipose subcutaneous - Adipose progenitor cells, Prostate - Urothelial cells
Subcellular location: Plasma membrane

Human Protein Atlas: CD44

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

CD44 · ENSG00000026508 · P16070