CD5

T-cell surface glycoprotein CD5. UniProt annotates extracellular residues 25–372.

Sequence and protein regions

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RNA expression by cell type

Percentage of cells with detected CD5 RNA in the public colon adenocarcinoma cell groups.

Regulatory T cells17.9%

CD4 T cells11.9%

CD8 T cells8.3%

Dendritic cells3.3%

Macrophages (group B)0.7%

Macrophages (group A)0.6%

Tumor cells0.3%

Fibroblasts0.3%

Endothelial cells0.2%

Adipocytes0.2%

B cells0.2%

Granulocytes0.0%

Natural killer cells0.0%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 109. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000110448
UniProt accession: P06127
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 495
Sequence SHA-256: c3334126628292d093cfd45394f323a3ca2846ccb365862068b5196f3c27f2b4

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Canonical amino-acid sequence

MPMGSLQPLATLYLLGMLVASCLGRLSWYDPDFQARLTRSNSKCQGQLEVYLKDGWHMVCSQSWGRSSKQWEDPSQASKVCQRLNCGVPLSLGPFLVTYTPQSSIICYGQLGSFSNCSHSRNDMCHSLGLTCLEPQKTTPPTTRPPPTTTPEPTAPPRLQLVAQSGGQHCAGVVEFYSGSLGGTISYEAQDKTQDLENFLCNNLQCGSFLKHLPETEAGRAQDPGEPREHQPLPIQWKIQNSSCTSLEHCFRKIKPQKSGRVLALLCSGFQPKVQSRLVGGSSICEGTVEVRQGAQWAALCDSSSARSSLRWEEVCREQQCGSVNSYRVLDAGDPTSRGLFCPHQKLSQCHELWERNSYCKKVFVTCQDPNPAGLAAGTVASIILALVLLVVLLVVCGPLAYKKLVKKFRQKKQRQWIGPTGMNQNMSFHRNHTATVRSHAENPTASHVDNEYSQPPRNSHLSAYPALEGALHRSSMQPDNSSDSDYDLHGAQRL

Sequence positions 1–495

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–24

Membrane-spanning segments

373–402 (Helical)

Source-annotated domains

25–372 (Extracellular); 403–495 (Cytoplasmic)

Source-annotated extracellular intervals

25–372

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
25	372	348	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 14f0bea1872f2748af1bcd6e62083dbfef9a84ee2b075ce765915baa2e2dc168 Amino-acid sequence for this intervalRLSWYDPDFQARLTRSNSKCQGQLEVYLKDGWHMVCSQSWGRSSKQWEDPSQASKVCQRLNCGVPLSLGPFLVTYTPQSSIICYGQLGSFSNCSHSRNDMCHSLGLTCLEPQKTTPPTTRPPPTTTPEPTAPPRLQLVAQSGGQHCAGVVEFYSGSLGGTISYEAQDKTQDLENFLCNNLQCGSFLKHLPETEAGRAQDPGEPREHQPLPIQWKIQNSSCTSLEHCFRKIKPQKSGRVLALLCSGFQPKVQSRLVGGSSICEGTVEVRQGAQWAALCDSSSARSSLRWEEVCREQQCGSVNSYRVLDAGDPTSRGLFCPHQKLSQCHELWERNSYCKKVFVTCQDPNP

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P06127

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subcellular_location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P13379}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P13379}.
transmembrane: TRANSMEM 373..402; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 25..372; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 403..495; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..24
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: T-cell surface glycoprotein CD5
Protein location: Transmembrane protein
Canonical sequence: P06127 · 495 amino acids
Extracellular region: UniProt annotates extracellular residues 25–372.

Expression in normal tissues

RNA specificity: Tissue enhanced
RNA distribution: Detected in many
RNA tissue-specific nTPM: lymphoid tissue: 43.3
Protein specificity: Tissue enhanced
Protein distribution: Detected in some
Immunohistochemistry reliability: Enhanced
Protein tissue-specific intensity: lymphoid tissue: 7,472,923.3
Tissue cell-type enrichment: Adipose subcutaneous - T-cells, Adipose visceral - T-cells, Adrenal gland - T-cells, Breast - T-cells, Colon - T-cells, Heart muscle - T-cells, Kidney - T-cells, Liver - T-cells, Lung - T-cells, Prostate - T-cells, Spleen - T-cells, Thyroid gland - T-cells

Human Protein Atlas: CD5

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

CD5 · ENSG00000110448 · P06127