CD55

Complement decay-accelerating factor. An extracellular span at residues 35–352 is derived from the signal peptide and GPI attachment annotation.

Sequence and protein regions

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RNA expression by cell type

Percentage of cells with detected CD55 RNA in the public colon adenocarcinoma cell groups.

Fibroblasts42.2%

Macrophages (group A)40.1%

Endothelial cells37.6%

Dendritic cells34.6%

Tumor cells27.0%

B cells26.8%

Granulocytes23.8%

Macrophages (group B)22.9%

Adipocytes18.3%

CD4 T cells17.5%

Natural killer cells13.8%

CD8 T cells11.2%

Regulatory T cells7.4%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 103. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000196352
UniProt accession: P08174
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 381
Sequence SHA-256: 989a894cc61bee9971c93b7be051d4d3718d7955ce6e3bb5f2d157377072f96f

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Canonical amino-acid sequence

MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTVQKPTTVNVPTTEVSPTSQKTTTKTTTPNAQATRSTPVSRTTKHFHETTPNKGSGTTSGTTRLLSGHTCFTLTGLLGTLVTMGLLT

Sequence positions 1–381

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–34

Lipid attachment sites

353–353 (GPI-anchor amidated serine)

Derived extracellular interval

35–352

The extracellular interval is derived from the signal peptide and GPI attachment site. It is a proposed construct interval.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
35	352	318	Sequence and source Basis interval-after-reviewed-signal-before-reviewed-gpi-anchor Evidence class topology-derived-construct-hypothesis Sequence SHA-256 d6f7ccb593427cdce678988ca83def4884ad3255e9e936c1be7a2c8a43dbe836 Amino-acid sequence for this intervalDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTVQKPTTVNVPTTEVSPTSQKTTTKTTTPNAQATRSTPVSRTTKHFHETTPNKGSGTT

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P08174

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subcellular_location: SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Lipid-anchor, GPI-anchor.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000269|PubMed:16503113}.; SUBCELLULAR LOCATION: [Isoform 4]: Secreted {ECO:0000269|PubMed:16503113}.; SUBCELLULAR LOCATION: [Isoform 5]: Secreted {ECO:0000269|PubMed:16503113}.; SUBCELLULAR LOCATION: [Isoform 6]: Cell membrane {ECO:0000305|PubMed:16503113}; Lipid-anchor, GPI-anchor {ECO:0000305|PubMed:16503113}.; SUBCELLULAR LOCATION: [Isoform 7]: Cell membrane {ECO:0000305|PubMed:16503113}; Lipid-anchor, GPI-anchor {ECO:0000305|PubMed:16503113}.
transmembrane: Not recorded
topological_domain: Not recorded
signal_peptide: SIGNAL 1..34; /evidence="ECO:0000269|PubMed:1712233, ECO:0000269|PubMed:2428813"
lipidation: LIPID 353; /note="GPI-anchor amidated serine"; /evidence="ECO:0000269|PubMed:1824699"

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Complement decay-accelerating factor
Protein location: GPI-anchored membrane protein
Canonical sequence: P08174 · 381 amino acids
Extracellular region: An extracellular span at residues 35–352 is derived from the signal peptide and GPI attachment annotation.

Expression in normal tissues

RNA specificity: Low tissue specificity
RNA distribution: Detected in all
Protein specificity: Tissue enhanced
Protein distribution: Detected in all
Immunohistochemistry reliability: Enhanced
Protein tissue-specific intensity: skin: 44,003,355.9
Tissue cell-type enrichment: Lung - Alveolar cells type 1, Spleen - Neutrophils_2, Testis - Early spermatids, Testis - Late spermatids

Human Protein Atlas: CD55

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

CD55 · ENSG00000196352 · P08174