CD68

Macrosialin. UniProt annotates extracellular residues 22–319.

Sequence and protein regions

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RNA expression by cell type

Percentage of cells with detected CD68 RNA in the public colon adenocarcinoma cell groups.

Macrophages (group B)77.8%

Macrophages (group A)48.6%

Dendritic cells26.8%

Fibroblasts18.8%

Granulocytes15.4%

Tumor cells13.2%

Endothelial cells5.5%

Adipocytes5.1%

B cells4.0%

Regulatory T cells3.3%

CD4 T cells1.7%

Natural killer cells1.7%

CD8 T cells1.5%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 55. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000129226
UniProt accession: P34810
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 354
Sequence SHA-256: 1ce65b514b2da647edba33b17ba6587a73fde0645399710a68c43668c3e9bfcf

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Canonical amino-acid sequence

MRLAVLFSGALLGLLAAQGTGNDCPHKKSATLLPSFTVTPTVTESTGTTSHRTTKSHKTTTHRTTTTGTTSHGPTTATHNPTTTSHGNVTVHPTSNSTATSQGPSTATHSPATTSHGNATVHPTSNSTATSPGFTSSAHPEPPPPSPSPSPTSKETIGDYTWTNGSQPCVHLQAQIQIRVMYTTQGGGEAWGISVLNPNKTKVQGSCEGAHPHLLLSFPYGHLSFGFMQDLQQKVVYLSYMAVEYNVSFPHAAQWTFSAQNASLRDLQAPLGQSFSCSNSSIILSPAVHLDLLSLRLQAAQLPHTGVFGQSFSCPSDRSILLPLIIGLILLGLLALVLIAFCIIRRRPSAYQAL

Sequence positions 1–354

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–21

Membrane-spanning segments

320–344 (Helical)

Source-annotated domains

22–319 (Extracellular); 345–354 (Cytoplasmic)

Source-annotated extracellular intervals

22–319

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
22	319	298	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 dee6a13448defa63dd34e87e5179d3f43b9ee7158b5282116644b5c42a7a93b7 Amino-acid sequence for this intervalNDCPHKKSATLLPSFTVTPTVTESTGTTSHRTTKSHKTTTHRTTTTGTTSHGPTTATHNPTTTSHGNVTVHPTSNSTATSQGPSTATHSPATTSHGNATVHPTSNSTATSPGFTSSAHPEPPPPSPSPSPTSKETIGDYTWTNGSQPCVHLQAQIQIRVMYTTQGGGEAWGISVLNPNKTKVQGSCEGAHPHLLLSFPYGHLSFGFMQDLQQKVVYLSYMAVEYNVSFPHAAQWTFSAQNASLRDLQAPLGQSFSCSNSSIILSPAVHLDLLSLRLQAAQLPHTGVFGQSFSCPSDRS

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P34810

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subcellular_location: SUBCELLULAR LOCATION: [Isoform Short]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform Long]: Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein.
transmembrane: TRANSMEM 320..344; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00740"
topological_domain: TOPO_DOM 22..319; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 345..354; /note="Cytoplasmic"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00740"
signal_peptide: SIGNAL 1..21; /evidence="ECO:0000255"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Macrosialin
Protein location: Transmembrane protein
Canonical sequence: P34810 · 354 amino acids
Extracellular region: UniProt annotates extracellular residues 22–319.

Expression in normal tissues

RNA specificity: Tissue enhanced
RNA distribution: Detected in all
RNA tissue-specific nTPM: lung: 337.0; lymphoid tissue: 349.0
Protein specificity: Tissue enriched
Protein distribution: Detected in single
Immunohistochemistry reliability: Enhanced
Immunofluorescence reliability: Supported
Protein tissue-specific intensity: lymphoid tissue: 97,677.0
Tissue cell-type enrichment: Adipose subcutaneous - Macrophages, Adipose visceral - Macrophages, Breast - Macrophages, Colon - Macrophages, Heart muscle - Macrophages, Lung - Macrophages, Pituitary gland - Macrophages, Prostate - Macrophages, Skeletal muscle - Macrophages, Spleen - Macrophages, Testis - Macrophages, Thyroid gland - Macrophages
Subcellular location: Golgi apparatus, Vesicles

Human Protein Atlas: CD68

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

CD68 · ENSG00000129226 · P34810