CD74

HLA class II histocompatibility antigen gamma chain. UniProt annotates extracellular residues 73–296.

Sequence and protein regions

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RNA expression by cell type

Percentage of cells with detected CD74 RNA in the public colon adenocarcinoma cell groups.

Macrophages (group B)94.2%

Dendritic cells90.8%

B cells88.2%

Macrophages (group A)80.0%

Regulatory T cells72.7%

Endothelial cells68.5%

CD8 T cells63.1%

CD4 T cells58.4%

Natural killer cells46.1%

Fibroblasts37.9%

Tumor cells36.5%

Adipocytes28.4%

Granulocytes25.9%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 165. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000019582
UniProt accession: P04233
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 296
Sequence SHA-256: f6909ab67f84bc41d8ef8976b6e5634ebcb9031613d297ac41e582c377b48728

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Canonical amino-acid sequence

MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQKPTDAPPKVLTKCQEEVSHIPAVHPGSFRPKCDENGNYLPLQCYGSIGYCWCVFPNGTEVPNTRSRGHHNCSESLELEDPSSGLGVTKQDLGPVPM

Sequence positions 1–296

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Membrane-spanning segments

47–72 (Helical; Signal-anchor for type II membrane protein)

Source-annotated domains

1–46 (Cytoplasmic); 73–296 (Extracellular)

Source-annotated extracellular intervals

73–296

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
73	296	224	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 4c6a65f31114216087588bc2f5a42600f9a25cb2046733fe44f984338750b607 Amino-acid sequence for this intervalQQQGRLDKLTVTSQNLQLENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQKPTDAPPKVLTKCQEEVSHIPAVHPGSFRPKCDENGNYLPLQCYGSIGYCWCVFPNGTEVPNTRSRGHHNCSESLELEDPSSGLGVTKQDLGPVPM

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P04233

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subcellular_location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Endoplasmic reticulum membrane. Golgi apparatus, trans-Golgi network. Endosome. Lysosome. Secreted {ECO:0000269|PubMed:25326458, ECO:0000269|PubMed:36213313, ECO:0000269|PubMed:37453717}. Note=Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane.; SUBCELLULAR LOCATION: [Isoform p41]: Late endosome {ECO:0000250|UniProtKB:P04441}. Lysosome {ECO:0000250|UniProtKB:P04441}.
transmembrane: TRANSMEM 47..72; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 1..46; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 73..296; /note="Extracellular"; /evidence="ECO:0000255"
signal_peptide: Not recorded
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: HLA class II histocompatibility antigen gamma chain
Protein location: Transmembrane protein
Canonical sequence: P04233 · 296 amino acids
Extracellular region: UniProt annotates extracellular residues 73–296.

Expression in normal tissues

RNA specificity: Tissue enhanced
RNA distribution: Detected in all
RNA tissue-specific nTPM: lymphoid tissue: 4,925.3
Protein specificity: Tissue enhanced
Protein distribution: Detected in all
Immunohistochemistry reliability: Enhanced
Immunofluorescence reliability: Supported
Protein tissue-specific intensity: lymphoid tissue: 91,191,182.8
Tissue cell-type enrichment: Adipose visceral - T-cells, Thyroid gland - T-cells
Subcellular location: Golgi apparatus

Human Protein Atlas: CD74

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

CD74 · ENSG00000019582 · P04233