Surface AtlasCD8A
T-cell surface glycoprotein CD8 alpha chain. UniProt annotates extracellular residues 22–182.
Sequence and protein regions
Explore the CD8A sequence, select annotated regions, and copy a request to continue in Codex.
Open this viewRNA expression by cell type
Percentage of cells with detected CD8A RNA in the public colon adenocarcinoma cell groups.
CD8 T cells50.4%
Natural killer cells13.3%
CD4 T cells5.3%
Regulatory T cells3.6%
Dendritic cells1.3%
Endothelial cells0.7%
Macrophages (group B)0.7%
Granulocytes0.7%
Fibroblasts0.6%
Tumor cells0.5%
B cells0.5%
Macrophages (group A)0.3%
Adipocytes0.2%
Sequence & binding sites
Choose a protein region, search amino-acid letters, or inspect a recorded binding site.
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Open the sequence explorerSequence annotations and source records
Canonical sequence and topology
- Target ID
- T-ENSG00000153563
- UniProt accession
- P01732
- Sequence state
- available
- Canonical sequence
- Yes
- Length in amino acids
- 235
- Sequence SHA-256
- ff7cd0b8004f0885dcc51de5b2a080fcc5d6888449c79ce2a57f791251041021
View and select the full canonical sequence
Gray shows the full canonical sequence. Colored spans mark the listed intervals.
Signal peptide
1–21
Membrane-spanning segments
183–203 (Helical)
Source-annotated domains
22–182 (Extracellular); 204–235 (Cytoplasmic)
Lipid attachment sites
206–206 (S-palmitoyl cysteine)
Source-annotated extracellular intervals
22–182
UniProt annotates the following extracellular intervals.
| Start | End | Length | Sequence and source |
|---|---|---|---|
| 22 | 182 | 161 | Sequence and source
|
Sequence and topology sources
- Source role
- canonical-sequence
- Source
- alphafold-db-canonical-uniprot-field
- Extracted field
- uniprotSequence
- Source row accession
- Not recorded
- Source role
- reviewed-topology
- Source
- UniProt reviewed human surface-field snapshot
- Extracted field
- Not recorded
- Source row accession
- P01732
Download source snapshot (gzip)
- subcellular_location
- SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:1460019, ECO:0000269|PubMed:17341584, ECO:0000269|PubMed:17678538}; Single-pass type I membrane protein. Note=CD8A localizes to lipid rafts only when associated with its partner CD8B. {ECO:0000269|PubMed:17341584}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:7923932}.
- transmembrane
- TRANSMEM 183..203; /note="Helical"; /evidence="ECO:0000255"
- topological_domain
- TOPO_DOM 22..182; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 204..235; /note="Cytoplasmic"; /evidence="ECO:0000255"
- signal_peptide
- SIGNAL 1..21
- lipidation
- LIPID 206; /note="S-palmitoyl cysteine"; /evidence="ECO:0000269|PubMed:17341584"
Protein identity and location
- Protein
- T-cell surface glycoprotein CD8 alpha chain
- Protein location
- Transmembrane protein
- Canonical sequence
- P01732 · 235 amino acids
- Extracellular region
- UniProt annotates extracellular residues 22–182.
Expression in normal tissues
- RNA specificity
- Tissue enriched
- RNA distribution
- Detected in many
- RNA tissue-specific nTPM
- lymphoid tissue: 216.0
- Protein specificity
- Group enriched
- Protein distribution
- Detected in many
- Immunohistochemistry reliability
- Enhanced
- Immunofluorescence reliability
- Supported
- Protein tissue-specific intensity
- fallopian tube: 1,160,292.4; intestine: 1,270,498.8; lymphoid tissue: 1,378,123.0
- Tissue cell-type enrichment
- Adipose subcutaneous - T-cells, Adipose visceral - T-cells, Adrenal gland - T-cells, Breast - T-cells, Colon - T-cells, Kidney - T-cells, Liver - T-cells, Lung - T-cells, Minor Salivary Gland - T-cells, Pancreas - T-cells, Pituitary gland - T-cells, Prostate - T-cells, Skin - T-cells, Stomach - T-cells, Thyroid gland - T-cells
- Subcellular location
- Plasma membrane
Sources and downloads
CD8A · ENSG00000153563 · P01732