CEACAM6

Cell adhesion molecule CEACAM6. An extracellular span at residues 35–319 is derived from the signal peptide and GPI attachment annotation.

Predicted protein structure

A downloaded AlphaFold model connects the CEACAM6 sequence to its predicted three-dimensional structure.

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RNA expression by cell type

Percentage of cells with detected CEACAM6 RNA in the public colon adenocarcinoma cell groups.

Tumor cells38.8%

Fibroblasts5.2%

Macrophages (group B)4.9%

Endothelial cells4.4%

Regulatory T cells3.8%

CD8 T cells3.6%

Macrophages (group A)3.4%

Granulocytes2.9%

CD4 T cells2.9%

B cells2.7%

Dendritic cells2.6%

Natural killer cells2.6%

Adipocytes1.6%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 80. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000086548
UniProt accession: P40199
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 344
Sequence SHA-256: 17a1c619e0eadf450f0fa212b4a084121252ad7f7ff798bd3b217f0b2a94f49f

View and select the full canonical sequence

Canonical amino-acid sequence

MGPPSAPPCRLHVPWKEVLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLAHNLPQNRIGYSWYKGERVDGNSLIVGYVIGTQQATPGPAYSGRETIYPNASLLIQNVTQNDTGFYTLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPEVQNTTYLWWVNGQSLPVSPRLQLSNGNMTLTLLSVKRNDAGSYECEIQNPASANRSDPVTLNVLYGPDVPTISPSKANYRPGENLNLSCHAASNPPAQYSWFINGTFQQSTQELFIPNITVNNSGSYMCQAHNSATGLNRTTVTMITVSGSAPVLSAVATVGITIGVLARVALI

Sequence positions 1–344

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–34

Lipid attachment sites

320–320 (GPI-anchor amidated glycine)

Derived extracellular interval

35–319

The extracellular interval is derived from the signal peptide and GPI attachment site. It is a proposed construct interval.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
35	319	285	Sequence and source Basis interval-after-reviewed-signal-before-reviewed-gpi-anchor Evidence class topology-derived-construct-hypothesis Sequence SHA-256 1a27b7b8114aebde40bec593d90be3a1fb77915e690ef6be2eea03329c5c0ff5 Amino-acid sequence for this intervalKLTIESTPFNVAEGKEVLLLAHNLPQNRIGYSWYKGERVDGNSLIVGYVIGTQQATPGPAYSGRETIYPNASLLIQNVTQNDTGFYTLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPEVQNTTYLWWVNGQSLPVSPRLQLSNGNMTLTLLSVKRNDAGSYECEIQNPASANRSDPVTLNVLYGPDVPTISPSKANYRPGENLNLSCHAASNPPAQYSWFINGTFQQSTQELFIPNITVNNSGSYMCQAHNSATGLNRTTVTMITVS

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P40199

Download source snapshot (gzip)

subcellular_location: SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:2317824}. Apical cell membrane {ECO:0000269|PubMed:10436421}. Cell surface {ECO:0000269|PubMed:1378450, ECO:0000269|PubMed:16204051, ECO:0000269|PubMed:2317824, ECO:0000269|PubMed:8776764, ECO:0000305|PubMed:2803308}. Note=Localized to the apical glycocalyx surface. {ECO:0000269|PubMed:10436421}.
transmembrane: Not recorded
topological_domain: Not recorded
signal_peptide: SIGNAL 1..34; /evidence="ECO:0000269|PubMed:15340161"
lipidation: LIPID 320; /note="GPI-anchor amidated glycine"; /evidence="ECO:0000250|UniProtKB:P31997"

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Cell adhesion molecule CEACAM6
Protein location: GPI-anchored membrane protein
Canonical sequence: P40199 · 344 amino acids
Extracellular region: An extracellular span at residues 35–319 is derived from the signal peptide and GPI attachment annotation.

Expression in normal tissues

RNA specificity: Tissue enhanced
RNA distribution: Detected in many
RNA tissue-specific nTPM: bone marrow: 171.4; esophagus: 194.9; intestine: 206.9; lung: 270.1; salivary gland: 177.8
Protein specificity: Tissue enriched
Protein distribution: Detected in all
Immunohistochemistry reliability: Enhanced
Protein tissue-specific intensity: bone marrow: 292,400,836.9
Tissue cell-type enrichment: Colon - Colon enterocytes, Lung - Alveolar cells type 1, Prostate - Urothelial cells, Skin - Eccrine sweat gland cells, Spleen - Neutrophils_1

Human Protein Atlas: CEACAM6

Structures

A predicted target model is available.

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Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

CEACAM6 · ENSG00000086548 · P40199