CEMIP2

Cell surface hyaluronidase CEMIP2. UniProt annotates extracellular residues 104–1383.

Sequence and protein regions

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RNA expression by cell type

Percentage of cells with detected CEMIP2 RNA in the public colon adenocarcinoma cell groups.

Endothelial cells35.7%

Natural killer cells17.6%

Tumor cells15.7%

Regulatory T cells15.0%

CD8 T cells13.2%

Macrophages (group B)12.5%

CD4 T cells11.2%

Fibroblasts9.9%

Macrophages (group A)7.3%

Adipocytes4.5%

B cells4.2%

Dendritic cells1.3%

Granulocytes1.0%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 603. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000135048
UniProt accession: Q9UHN6
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 1383
Sequence SHA-256: 3f8119b9dfc7d5e59c2128dbfca6b4a8561e90be0d2f656053b993ca5adc180e

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Canonical amino-acid sequence

MYATDSRGHSPAFLQPQNGNSRHPSGYVPGKVVPLRPPPPPKSQASAKFTSIRREDRATFAFSPEEQQAQRESQKQKRHKNTFICFAITSFSFFIALAIILGISSKYAPDENCPDQNPRLRNWDPGQDSAKQVVIKEGDMLRLTSDATVHSIVIQDGGLLVFGDNKDGSRNITLRTHYILIQDGGALHIGAEKCRYKSKATITLYGKSDEGESMPTFGKKFIGVEAGGTLELHGARKASWTLLARTLNSSGLPFGSYTFEKDFSRGLNVRVIDQDTAKILESERFDTHEYRNESRRLQEFLRFQDPGRIVAIAVGDSAAKSLLQGTIQMIQERLGSELIQGLGYRQAWALVGVIDGGSTSCNESVRNYENHSSGGKALAQREFYTVDGQKFSVTAYSEWIEGVSLSGFRVEVVDGVKLNLLDDVSSWKPGDQIVVASTDYSMYQAEEFTLLPCSECSHFQVKVKETPQFLHMGEIIDGVDMRAEVGILTRNIVIQGEVEDSCYAENQCQFFDYDTFGGHIMIMKNFTSVHLSYVELKHMGQQQMGRYPVHFHLCGDVDYKGGYRHATFVDGLSIHHSFSRCITVHGTNGLLIKDTIGFDTLGHCFFLEDGIEQRNTLFHNLGLLTKPGTLLPTDRNNSMCTTMRDKVFGNYIPVPATDCMAVSTFWIAHPNNNLINNAAAGSQDAGIWYLFHKEPTGESSGLQLLAKPELTPLGIFYNNRVHSNFKAGLFIDKGVKTTNSSAADPREYLCLDNSARFRPHQDANPEKPRVAALIDRLIAFKNNDNGAWVRGGDIIVQNSAFADNGIGLTFASDGSFPSDEGSSQEVSESLFVGESRNYGFQGGQNKYVGTGGIDQKPRTLPRNRTFPIRGFQIYDGPIHLTRSTFKKYVPTPDRYSSAIGFLMKNSWQITPRNNISLVKFGPHVSLNVFFGKPGPWFEDCEMDGDKNSIFHDIDGSVTGYKDAYVGRMDNYLIRHPSCVNVSKWNAVICSGTYAQVYVQTWSTQNLSMTITRDEYPSNPMVLRGINQKAAFPQYQPVVMLEKGYTIHWNGPAPRTTFLYLVNFNKNDWIRVGLCYPSNTSFQVTFGYLQRQNGSLSKIEEYEPVHSLEELQRKQSERKFYFDSSTGLLFLYLKAKSHRHGHSYCSSQGCERVKIQAATDSKDISNCMAKAYPQYYRKPSVVKRMPAMLTGLCQGCGTRQVVFTSDPHKSYLPVQFQSPDKAETQRGDPSVISVNGTDFTFRSAGVLLLVVDPCSVPFRLTEKTVFPLADVSRIEEYLKTGIPPRSIVLLSTRGEIKQLNISHLLVPLGLAKPAHLYDKGSTIFLGFSGNFKPSWTKLFTSPAGQGLGVLEQFIPLQLDEYGCPRATTVRRRDLELLKQASKAH

Sequence positions 1–1383

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Membrane-spanning segments

83–103 (Helical; Signal-anchor for type II membrane protein)

Source-annotated domains

1–82 (Cytoplasmic); 104–1383 (Extracellular)

Source-annotated extracellular intervals

104–1383

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
104	1383	1280	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 a767329d6a5ad102c0299116fc17caca99cf6326f7a93140ea6ffdfbfd2a03e5 Amino-acid sequence for this intervalSSKYAPDENCPDQNPRLRNWDPGQDSAKQVVIKEGDMLRLTSDATVHSIVIQDGGLLVFGDNKDGSRNITLRTHYILIQDGGALHIGAEKCRYKSKATITLYGKSDEGESMPTFGKKFIGVEAGGTLELHGARKASWTLLARTLNSSGLPFGSYTFEKDFSRGLNVRVIDQDTAKILESERFDTHEYRNESRRLQEFLRFQDPGRIVAIAVGDSAAKSLLQGTIQMIQERLGSELIQGLGYRQAWALVGVIDGGSTSCNESVRNYENHSSGGKALAQREFYTVDGQKFSVTAYSEWIEGVSLSGFRVEVVDGVKLNLLDDVSSWKPGDQIVVASTDYSMYQAEEFTLLPCSECSHFQVKVKETPQFLHMGEIIDGVDMRAEVGILTRNIVIQGEVEDSCYAENQCQFFDYDTFGGHIMIMKNFTSVHLSYVELKHMGQQQMGRYPVHFHLCGDVDYKGGYRHATFVDGLSIHHSFSRCITVHGTNGLLIKDTIGFDTLGHCFFLEDGIEQRNTLFHNLGLLTKPGTLLPTDRNNSMCTTMRDKVFGNYIPVPATDCMAVSTFWIAHPNNNLINNAAAGSQDAGIWYLFHKEPTGESSGLQLLAKPELTPLGIFYNNRVHSNFKAGLFIDKGVKTTNSSAADPREYLCLDNSARFRPHQDANPEKPRVAALIDRLIAFKNNDNGAWVRGGDIIVQNSAFADNGIGLTFASDGSFPSDEGSSQEVSESLFVGESRNYGFQGGQNKYVGTGGIDQKPRTLPRNRTFPIRGFQIYDGPIHLTRSTFKKYVPTPDRYSSAIGFLMKNSWQITPRNNISLVKFGPHVSLNVFFGKPGPWFEDCEMDGDKNSIFHDIDGSVTGYKDAYVGRMDNYLIRHPSCVNVSKWNAVICSGTYAQVYVQTWSTQNLSMTITRDEYPSNPMVLRGINQKAAFPQYQPVVMLEKGYTIHWNGPAPRTTFLYLVNFNKNDWIRVGLCYPSNTSFQVTFGYLQRQNGSLSKIEEYEPVHSLEELQRKQSERKFYFDSSTGLLFLYLKAKSHRHGHSYCSSQGCERVKIQAATDSKDISNCMAKAYPQYYRKPSVVKRMPAMLTGLCQGCGTRQVVFTSDPHKSYLPVQFQSPDKAETQRGDPSVISVNGTDFTFRSAGVLLLVVDPCSVPFRLTEKTVFPLADVSRIEEYLKTGIPPRSIVLLSTRGEIKQLNISHLLVPLGLAKPAHLYDKGSTIFLGFSGNFKPSWTKLFTSPAGQGLGVLEQFIPLQLDEYGCPRATTVRRRDLELLKQASKAH

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: Q9UHN6

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subcellular_location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q5FWI3}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q5FWI3}.
transmembrane: TRANSMEM 83..103; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 1..82; /note="Cytoplasmic"; /evidence="ECO:0000250|UniProtKB:Q5FWI3"; TOPO_DOM 104..1383; /note="Extracellular"; /evidence="ECO:0000250|UniProtKB:Q5FWI3"
signal_peptide: Not recorded
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Cell surface hyaluronidase CEMIP2
Protein location: Transmembrane protein
Canonical sequence: Q9UHN6 · 1,383 amino acids
Extracellular region: UniProt annotates extracellular residues 104–1383.

Expression in normal tissues

RNA specificity: Tissue enhanced
RNA distribution: Detected in all
RNA tissue-specific nTPM: parathyroid gland: 87.0; placenta: 74.8
Protein specificity: Tissue enhanced
Protein distribution: Detected in many
Immunohistochemistry reliability: Approved
Immunofluorescence reliability: Supported
Protein tissue-specific intensity: lung: 7,920,669.5; lymphoid tissue: 6,926,863.5
Tissue cell-type enrichment: Heart muscle - Endothelial cells, Minor Salivary Gland - Minor salivary glandular cells
Subcellular location: Plasma membrane

Human Protein Atlas: CEMIP2

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

CEMIP2 · ENSG00000135048 · Q9UHN6