CKAP4

Cytoskeleton-associated protein 4. UniProt annotates extracellular residues 128–602.

Sequence and protein regions

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RNA expression by cell type

Percentage of cells with detected CKAP4 RNA in the public colon adenocarcinoma cell groups.

Fibroblasts34.1%

Endothelial cells18.0%

Tumor cells16.2%

Adipocytes11.2%

B cells11.2%

Macrophages (group B)5.9%

Macrophages (group A)5.9%

CD4 T cells4.1%

Granulocytes3.6%

Dendritic cells1.3%

Regulatory T cells1.1%

CD8 T cells0.5%

Natural killer cells0.2%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 416. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000136026
UniProt accession: Q07065
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 602
Sequence SHA-256: a69193e28b483478d78dd2a26eb76607fe5b7375c8a543976bc87874b0c17f41

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Canonical amino-acid sequence

MPSAKQRGSKGGHGAASPSEKGAHPSGGADDVAKKPPPAPQQPPPPPAPHPQQHPQQHPQNQAHGKGGHRGGGGGGGKSSSSSSASAAAAAAAASSSASCSRRLGRALNFLFYLALVAAAAFSGWCVHHVLEEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVKQGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDNIAIFTEVQKRSQKEINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSAKSREWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQVASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQLVLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSLDNLKASVSQVEADLKMLRTAVDSLVAYSVKIETNENNLESAKGLLDDLRNDLDRLFVKVEKIHEKV

Sequence positions 1–602

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Membrane-spanning segments

107–127 (Helical)

Source-annotated domains

1–106 (Cytoplasmic); 128–602 (Extracellular)

Lipid attachment sites

100–100 (S-palmitoyl cysteine; by ZDHHC2)

Source-annotated extracellular intervals

128–602

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
128	602	475	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 1a4045c5c009b5785429320ca7d31653607f924b1a64a19041527e3de22bfb05 Amino-acid sequence for this intervalHHVLEEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVKQGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDNIAIFTEVQKRSQKEINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSAKSREWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQVASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQLVLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSLDNLKASVSQVEADLKMLRTAVDSLVAYSVKIETNENNLESAKGLLDDLRNDLDRLFVKVEKIHEKV

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: Q07065

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subcellular_location: SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18296695, ECO:0000269|PubMed:19144824}; Single-pass type II membrane protein. Cell membrane {ECO:0000269|PubMed:18296695, ECO:0000269|PubMed:19144824}; Single-pass type II membrane protein. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Note=Translocates to the perinuclear region upon APF-stimulation.
transmembrane: TRANSMEM 107..127; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 1..106; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 128..602; /note="Extracellular"; /evidence="ECO:0000255"
signal_peptide: Not recorded
lipidation: LIPID 100; /note="S-palmitoyl cysteine; by ZDHHC2"; /evidence="ECO:0000269|PubMed:18296695, ECO:0000269|PubMed:19144824"

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Cytoskeleton-associated protein 4
Protein location: Transmembrane protein
Canonical sequence: Q07065 · 602 amino acids
Extracellular region: UniProt annotates extracellular residues 128–602.

Expression in normal tissues

RNA specificity: Low tissue specificity
RNA distribution: Detected in all
Protein specificity: Low tissue specificity
Protein distribution: Detected in all
Immunohistochemistry reliability: Enhanced
Immunofluorescence reliability: Supported
Tissue cell-type enrichment: Adipose subcutaneous - Adipose progenitor cells, Adipose visceral - Adipose progenitor cells
Subcellular location: Endoplasmic reticulum

Human Protein Atlas: CKAP4

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

CKAP4 · ENSG00000136026 · Q07065