CTNND1

Catenin delta-1. The canonical sequence contains 968 amino acids.

Sequence and protein regions

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RNA expression by cell type

Percentage of cells with detected CTNND1 RNA in the public colon adenocarcinoma cell groups.

Endothelial cells43.2%

Tumor cells30.1%

Macrophages (group B)24.9%

Fibroblasts23.5%

Macrophages (group A)14.9%

Adipocytes12.0%

Dendritic cells8.5%

Granulocytes6.0%

B cells2.1%

Regulatory T cells1.9%

Natural killer cells1.9%

CD4 T cells1.4%

CD8 T cells1.1%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 331. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000198561
UniProt accession: O60716
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 968
Sequence SHA-256: 3654c491186ae9d8a1ff3ccfdd2d1fcaa05e4f792654a32899f5896089dc67e8

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Canonical amino-acid sequence

MDDSEVESTASILASVKEQEAQFEKLTRALEEERRHVSAQLERVRVSPQDANPLMANGTLTRRHQNGRFVGDADLERQKFSDLKLNGPQDHSHLLYSTIPRMQEPGQIVETYTEEDPEGAMSVVSVETSDDGTTRRTETTVKKVVKTVTTRTVQPVAMGPDGLPVDASSVSNNYIQTLGRDFRKNGNGGPGPYVGQAGTATLPRNFHYPPDGYSRHYEDGYPGGSDNYGSLSRVTRIEERYRPSMEGYRAPSRQDVYGPQPQVRVGGSSVDLHRFHPEPYGLEDDQRSMGYDDLDYGMMSDYGTARRTGTPSDPRRRLRSYEDMIGEEVPSDQYYWAPLAQHERGSLASLDSLRKGGPPPPNWRQPELPEVIAMLGFRLDAVKSNAAAYLQHLCYRNDKVKTDVRKLKGIPVLVGLLDHPKKEVHLGACGALKNISFGRDQDNKIAIKNCDGVPALVRLLRKARDMDLTEVITGTLWNLSSHDSIKMEIVDHALHALTDEVIIPHSGWEREPNEDCKPRHIEWESVLTNTAGCLRNVSSERSEARRKLRECDGLVDALIFIVQAEIGQKDSDSKLVENCVCLLRNLSYQVHREIPQAERYQEAAPNVANNTGPHAASCFGAKKGKDEWFSRGKKPIEDPANDTVDFPKRTSPARGYELLFQPEVVRIYISLLKESKTPAILEASAGAIQNLCAGRWTYGRYIRSALRQEKALSAIADLLTNEHERVVKAASGALRNLAVDARNKELIGKHAIPNLVKNLPGGQQNSSWNFSEDTVISILNTINEVIAENLEAAKKLRETQGIEKLVLINKSGNRSEKEVRAAALVLQTIWGYKELRKPLEKEGWKKSDFQVNLNNASRSQSSHSYDDSTLPLIDRNQKSDKKPDREEIQMSNMGSNTKSLDNNYSTPNERGDHNRTLDRSGDLGDMEPLKGTTPLMQDEGQESLEEELDVLVLDDEGGQVSYPSMQKI

This collection has no explicit extracellular interval for this protein.

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: O60716

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subcellular_location: SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000269|PubMed:11896187}. Cytoplasm {ECO:0000269|PubMed:15240885, ECO:0000269|PubMed:17047063}. Nucleus {ECO:0000269|PubMed:11896187, ECO:0000269|PubMed:17115030}. Cell membrane {ECO:0000269|PubMed:15240885, ECO:0000269|PubMed:17047063}. Cell junction {ECO:0000269|PubMed:18343367}. Note=Interaction with GLIS2 promotes nuclear translocation (By similarity). Detected at cell-cell contacts (PubMed:15240885, PubMed:17047063). NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm (PubMed:17047063). CDH1 enhances cell membrane localization (PubMed:15240885). Localizes to cell-cell contacts as keratinocyte differentiation progresses (By similarity). {ECO:0000250|UniProtKB:P30999, ECO:0000269|PubMed:11896187, ECO:0000269|PubMed:15240885, ECO:0000269|PubMed:17047063}.; SUBCELLULAR LOCATION: [Isoform 1A]: Nucleus {ECO:0000269|PubMed:11896187}.; SUBCELLULAR LOCATION: [Isoform 2A]: Nucleus {ECO:0000269|PubMed:11896187}.; SUBCELLULAR LOCATION: [Isoform 3A]: Nucleus {ECO:0000269|PubMed:11896187}.; SUBCELLULAR LOCATION: [Isoform 4A]: Cytoplasm {ECO:0000269|PubMed:11896187}.; SUBCELLULAR LOCATION: [Isoform 1AB]: Cytoplasm {ECO:0000269|PubMed:11896187}.
transmembrane: Not recorded
topological_domain: Not recorded
signal_peptide: Not recorded
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Catenin delta-1
Protein location: Cell junctions, cytoplasm, nucleus and cell membrane
Canonical sequence: O60716 · 968 amino acids

Expression in normal tissues

RNA specificity: Low tissue specificity
RNA distribution: Detected in all
Protein specificity: Low tissue specificity
Protein distribution: Detected in all
Immunohistochemistry reliability: Enhanced
Immunofluorescence reliability: Enhanced
Tissue cell-type enrichment: Adipose subcutaneous - Endothelial cells, Adrenal gland - Adrenal cortex cells, Prostate - Prostate basal glandular cells, Skin - Keratinocyte (other), Spleen - Endothelial cells, Stomach - Gastric mucous cells
Subcellular location: Plasma membrane

Human Protein Atlas: CTNND1

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

CTNND1 · ENSG00000198561 · O60716