DDR1

Epithelial discoidin domain-containing receptor 1. UniProt annotates extracellular residues 21–417.

Predicted protein structure

A downloaded AlphaFold model connects the DDR1 sequence to its predicted three-dimensional structure.

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RNA expression by cell type

Percentage of cells with detected DDR1 RNA in the public colon adenocarcinoma cell groups.

Tumor cells24.9%

Fibroblasts4.5%

Macrophages (group B)2.3%

Adipocytes2.0%

Endothelial cells1.7%

Macrophages (group A)1.3%

B cells1.2%

Natural killer cells1.0%

CD4 T cells0.7%

CD8 T cells0.7%

Granulocytes0.7%

Dendritic cells0.7%

Regulatory T cells0.6%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 269. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000204580
UniProt accession: Q08345
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 913
Sequence SHA-256: 8668509c1c5a38917d30a46f023eded94584a129e7dac90b7e80fd4e56d943ac

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Canonical amino-acid sequence

MGPEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTAARHSRLESSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRLRYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRVELYGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLDDFRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPGGVECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLFSEISFISDVVNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTAILIGCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTILINNRPGPREPPPYQEPRPRGNPPHSAPCVPNGSALLLSNPAYRLLLATYARPPRGPGPPTPAWAKPTNTQAYSGDYMEPEKPGAPLLPPPPQNSVPHYAEADIVTLQGVTGGNTYAVPALPPGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAEDALNTV

Sequence positions 1–913

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–18

Membrane-spanning segments

418–438 (Helical)

Source-annotated domains

21–417 (Extracellular); 439–913 (Cytoplasmic)

Source-annotated extracellular intervals

21–417

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
21	417	397	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 54bdea7861acc0cef0dfb165e531e4dec42502ce2c7b5e7cde65b78ec231f2f7 Amino-acid sequence for this intervalDMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTAARHSRLESSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRLRYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRVELYGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLDDFRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPGGVECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLFSEISFISDVVNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTA

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: Q08345

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subcellular_location: SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane; Single-pass type I membrane protein.
transmembrane: TRANSMEM 418..438; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 21..417; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 439..913; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..18; /evidence="ECO:0000255"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Epithelial discoidin domain-containing receptor 1
Protein location: Transmembrane protein
Canonical sequence: Q08345 · 913 amino acids
Extracellular region: UniProt annotates extracellular residues 21–417.

Expression in normal tissues

RNA specificity: Low tissue specificity
RNA distribution: Detected in many
Protein specificity: Group enriched
Protein distribution: Detected in some
Immunohistochemistry reliability: Approved
Immunofluorescence reliability: Supported
Protein tissue-specific intensity: cerebral cortex: 1,899,733.5; fallopian tube: 2,448,047.4; salivary gland: 5,250,407.5
Tissue cell-type enrichment: Adrenal gland - Adrenal cortex cells, Breast - Breast glandular cells, Minor Salivary Gland - Minor salivary glandular cells, Thyroid gland - Thyroid glandular cells
Subcellular location: Plasma membrane

Human Protein Atlas: DDR1

Structures

A predicted target model is available.

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Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

DDR1 · ENSG00000204580 · Q08345